Synthetic Communications最新文献

{"title":"Synthesis and antibacterial evaluation of some pyrimidine hybrids as potential MRSA inhibitors","authors":"Yasser A. El-Ossaily (Conceptualization Data curation Formal analysis Funding acquisition Investigation Methodology Project administration) ,&nbsp;Ahmed E. M. Mekky (Conceptualization Data curation Formal analysis Investigation Methodology Project administration Resources Software Supervision Validation Visualization Writing – original draft Writing – review & editing) ,&nbsp;Ahmed A. M. Ahmed (Conceptualization Data curation Formal analysis Investigation Methodology Project administration Resources Software Supervision Validation Visualization Writing – original draft Writing – review & editing) ,&nbsp;Mohamed Y. El-Sayed (Conceptualization Data curation Formal analysis Investigation Methodology Project administration) ,&nbsp;Sherif M. H. Sanad (Conceptualization Data curation Formal analysis Investigation Methodology Project administration Resources Software Supervision Validation Visualization Writing – original draft Writing – review & editing)","doi":"10.1080/00397911.2026.2649256","DOIUrl":"10.1080/00397911.2026.2649256","url":null,"abstract":"<div><div>Research on developing new treatments for methicillin-resistant <em>Staphylococcus aureus</em> (MRSA), which is extremely dangerous, is a major concern. New aryl-linked 2,4-diaminopyrimidine-5-carboxamides <strong>1</strong> and their bis-analogues connected to various spacers <strong>2</strong> were prepared herein and examined as possible anti-MRSA inhibitors. These hybrids are efficiently prepared by reacting a ternary mixture of pyrimidine-linked 2-cyanoacetamide and guanidine nitrate with the suitable aromatic aldehydes or bis(aldehydes). The reaction was carried out in DMSO at reflux for 5-8 h containing anhydrous potassium carbonate. The alkane-linked bis-products <strong>2b-2e</strong> displayed promising potency, with MIC and MBC ranging from 2.21-2.33 and 4.43-4.66 µM, respectively, against <em>S. aureus</em> and <em>E. coli</em>. Moreover, the hexane-linked bis-product <strong>2e</strong> showed significant anti-MRSA activity with MIC/MBC of 2.21/8.87 µM. In the presence of an S9 mixture, the Ames test showed that <strong>2b-2e</strong> are not mutagenic to <em>Salmonella</em> strains.</div></div>","PeriodicalId":22119,"journal":{"name":"Synthetic Communications","volume":"56 8","pages":"Pages 615-633"},"PeriodicalIF":1.8,"publicationDate":"2026-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147748889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthesis of bioactive benzo[d] [1,3] dioxolyl–1,8-naphthyridine scaffolds and evaluation of their anticancer activity","authors":"Venkata Konda Prasad. B. (Writing – original draft Writing – review & editing) ,&nbsp;G Venkata Haritha (Formal analysis) ,&nbsp;Kavati Shireesha (Data curation) ,&nbsp;Kumara Swamy Jella (Supervision)","doi":"10.1080/00397911.2026.2655336","DOIUrl":"10.1080/00397911.2026.2655336","url":null,"abstract":"<div><div>Cancer, the second leading cause of death, demands new therapies. Small molecule drugs can provide strong and targeted therapy. Herein, we report the design and synthesis of biologically active 3-(benzo[1,3]dioxol-5-yl)-<em>N</em>-(3-aryl-1,8-naphthyridin-2-yl)-1,8-naphthyridin-2-amine derivatives <em>via</em> a microwave-assisted Buchwald–Hartwig coupling strategy and their anticancer activity evaluation. The molecular structures of the synthesized compounds were confirmed by spectroscopic methods. The synthesized compounds were evaluated for their <em>in vitro</em> anticancer activity against three human cancer cell lines. Several compounds demonstrated promising anticancer activity. Compounds 3e and 3h exhibited the most potent anticancer activity among the series. Compound 3e showed IC₅₀ values of 6.37 ± 0.09 μM (MCF-7), 8.29 ± 0.76 μM (A549), and 10.22 ± 0.41 μM (SiHa), while compound 3h displayed IC₅₀ values of 9.27 ± 0.18 μM, 11.65 ± 0.54 μM, and 15.65 ± 0.26 μM against the three cancer cell lines.</div></div>","PeriodicalId":22119,"journal":{"name":"Synthetic Communications","volume":"56 8","pages":"Pages 634-644"},"PeriodicalIF":1.8,"publicationDate":"2026-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147748890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Iron nanoparticles drive a greener path to imidazoles","authors":"Shubham Sharma (Writing – original draft Writing – review & editing) ,&nbsp;Swati Rani (Writing – original draft) ,&nbsp;Nutan Rani (Investigation Validation Visualization) ,&nbsp;Man Vir Singh (Conceptualization Data curation Formal analysis) ,&nbsp;Pooja Sharma (Investigation Methodology Software) ,&nbsp;Magdi E. A. Zaki (Conceptualization Resources) ,&nbsp;Sobhi M. Gomha (Supervision Writing – review & editing) ,&nbsp; Vaishali (Supervision Writing – original draft)","doi":"10.1080/00397911.2026.2636917","DOIUrl":"10.1080/00397911.2026.2636917","url":null,"abstract":"<div><div>The advancement of effective and sustainable synthetic approaches for organic heterocycles holds considerable importance, given their extensive applications in pharmaceuticals, agrochemicals, and materials science. In this context, imidazole derivatives have garnered significant interest due to their varied biological activities and structural adaptability. In recent years, Fe-NPs have surfaced as noteworthy green catalysts due to their minimal toxicity, extensive surface area, magnetic separability, and abundance in nature. This review article investigates the pivotal function of Fe-NPs in the synthesis of imidazole derivatives through two-component and multicomponent reactions conducted under mild and environmentally sustainable conditions. Moreover, the application of Fe-NPs significantly reduces the necessity for toxic reagents and solvents, thereby adhering to the tenets of green chemistry. This manuscript underscores the promise of Fe-NPs as a multifaceted and economically viable catalyst for the synthesis of biologically significant imidazole frameworks, presenting a compelling foundation for future developments in heterocyclic chemistry.</div></div>","PeriodicalId":22119,"journal":{"name":"Synthetic Communications","volume":"56 8","pages":"Pages 573-614"},"PeriodicalIF":1.8,"publicationDate":"2026-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147748891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultrasound-assisted one-pot multicomponent synthesis of 6-amino-5-cyano-4-aryl pyrimidines under solvent- and catalyst-free conditions: An efficient and greener approach","authors":"Biswaprakash Sahoo (Methodology Validation) ,&nbsp;Vinit V. Agnihotri (Formal analysis) ,&nbsp;Yatin U. Gadkari (Conceptualization Supervision Writing – review & editing)","doi":"10.1080/00397911.2026.2651925","DOIUrl":"10.1080/00397911.2026.2651925","url":null,"abstract":"<div><div>A mild and eco-friendly procedure has been developed for the synthesis of 6-amino-5-cyano-4-aryl pyrimidine derivatives via one-pot multicomponent reaction of aldehydes with malononitrile and urea/thiourea in the presence of ultrasound irradiation. The solvent and catalyst-free approach, yielding high-purity products, is the major advantage of the reported protocol. The method is in good accordance with the principles of green chemistry, as demonstrated by a high Atom Economy (91.40%), a low E-Factor value (0.14), a high Eco Scale score (95), and a PMI value of 1.14, indicating an environmentally benign nature with efficient material usage.</div></div>","PeriodicalId":22119,"journal":{"name":"Synthetic Communications","volume":"56 8","pages":"Pages 645-654"},"PeriodicalIF":1.8,"publicationDate":"2026-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147748888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Design, synthesis, and biological evaluation of novel urokinase (uPA) inhibitors as potential therapeutics for prostate cancer","authors":"Mardia T. El Sayed (Conceptualization Data curation Formal analysis Investigation Methodology Resources Software Supervision Validation Visualization Writing – original draft Writing – review & editing) ,&nbsp;Huriyyah A. Alturaifi (Conceptualization Data curation Formal analysis Investigation Methodology Software Writing – review & editing) ,&nbsp;L. O. Mallasiy (Data curation Formal analysis Project administration Resources Validation Writing – review & editing) ,&nbsp;Ahmed H. Ragab (Formal analysis Funding acquisition Project administration Resources Writing – review & editing) ,&nbsp;Abeer E. Mahmoud (Conceptualization Data curation Formal analysis Investigation Methodology Supervision Writing – original draft Writing – review & editing) ,&nbsp;Mamdouh M. Ali (Conceptualization Data curation Formal analysis Investigation Methodology Resources Software Supervision Visualization Writing – original draft Writing – review & editing) ,&nbsp;Shahenda M. El-Messery (Conceptualization Data curation Formal analysis Investigation Methodology Software Writing – original draft Writing – review & editing)","doi":"10.1080/00397911.2026.2656899","DOIUrl":"10.1080/00397911.2026.2656899","url":null,"abstract":"<div><div>The high levels of uPA and uPAR are often associated with poor prognosis in cancers such as prostate, breast, and pancreatic cancer. Inhibition of uPA is being researched due to a high significance. Therefore, designing small molecules that selectively inhibit uPA is an active area of anticancer drug research. A smooth cyclization method was developed for the synthesis of novel urokinase-type plasminogen activator (uPA) inhibitors using nitromethane, ethylenediamine, and aromatic dialdehydes. The resulting nitro- and amino-diazepane derivatives were fully characterized and screened for anticancer activity against prostate cancer (PC3) cells. Several compounds, notably <strong>3i</strong>, <strong>3h</strong>, <strong>5b</strong>, and <strong>7a</strong>, showed strong cytotoxicity comparable to doxorubicin with minimal toxicity toward normal cells. These compounds also significantly inhibited uPA expression, confirming their potential mechanism of action. Molecular docking and surface mapping studies supported strong interactions within the uPA active site, while drug-likeness evaluations indicated good bioavailability and Lipinski compliance. Overall, the synthesized compounds represent promising lead candidates for the development of selective anti-prostate cancer agents targeting the uPA system.</div></div>","PeriodicalId":22119,"journal":{"name":"Synthetic Communications","volume":"56 8","pages":"Pages 655-678"},"PeriodicalIF":1.8,"publicationDate":"2026-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147748893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthesis and molecular docking studies of new fragrant campholenal derived succinate diesters","authors":"Yeşim Çat (Conceptualization Data curation Formal analysis Investigation Methodology Writing – original draft Writing – review & editing) ,&nbsp;Belkız Bilgin Eran (Conceptualization Validation Visualization Writing – review & editing) ,&nbsp;Akın Sağırlı (Conceptualization Supervision Validation Writing – review & editing) ,&nbsp;Havva Acar (Investigation Visualization) ,&nbsp;Harun Taşdemir (Data curation Resources Visualization) ,&nbsp;Özge Kavas (Data curation Resources Visualization) ,&nbsp;Onur Can Yazıcı (Software Writing – review & editing)","doi":"10.1080/00397911.2026.2626798","DOIUrl":"10.1080/00397911.2026.2626798","url":null,"abstract":"<div><div>Succinate diesters are a versatile class of compounds with diverse applications owing to their unique chemical properties. This study reports the synthesis of novel campholenal-derived succinate diesters, exploiting the structural diversity of campholenal, an important raw material in fragrance chemistry. Monoester succinates were first prepared from low-molecular-weight alcohols and subsequently esterified with campholenol and its <em>α</em>-methyl- and <em>α</em>-dimethyl-substituted derivatives to afford a series of diesters. All intermediates and final products were structurally characterized by IR, NMR, and TOF-LCMS analyses. Olfactory evaluation by an expert panel revealed that propyl-substituted derivatives exhibited enhanced odor longevity, while methyl and dimethyl substitutions on the campholenol moiety significantly influenced odor characteristics. To rationalize these observations at the molecular level, docking studies of compounds <strong>9a–i</strong> were performed against the human olfactory receptor OR51E2. The results supported the experimental findings by indicating favorable binding affinities and interaction patterns for compounds associated with increased odor durability.</div></div>","PeriodicalId":22119,"journal":{"name":"Synthetic Communications","volume":"56 7","pages":"Pages 497-512"},"PeriodicalIF":1.8,"publicationDate":"2026-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147707188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthesis and structure–activity relationships of chlordimeform imine analogues against Chilo suppressalis","authors":"Xiyan Tang (Investigation Software Validation) ,&nbsp;Lijie Che (Formal analysis Investigation Methodology Validation Writing – original draft) ,&nbsp;Yanmin Huang (Conceptualization Funding acquisition Methodology Project administration) ,&nbsp;Jianguo Cui (Conceptualization Project administration Supervision) ,&nbsp;Zhiping Liu (Conceptualization Investigation Supervision Writing – review & editing)","doi":"10.1080/00397911.2026.2640565","DOIUrl":"10.1080/00397911.2026.2640565","url":null,"abstract":"<div><div>To address the high carcinogenicity of 4-chloro-2-methylaniline (a metabolite of traditional chlordimeform), thirty chlordimeform imine analogues were synthesized using chlordimeform as the lead compound, retaining the core amidine group (–N = CH–N(CH₃)₂) while modifying the benzene ring. The synthesized amidine structures were confirmed by ¹H/¹³C/¹⁹F NMR spectroscopy. Insecticidal activity against resistant <em>Chilo suppressalis</em> was evaluated <em>via</em> the soaked water-oat stem method. At a concentration of 50 μg/mL, compounds <strong>4d</strong>, <strong>4m</strong>, <strong>9c</strong>, and <strong>9d</strong> exhibited a corrected mortality rate of more than 38.67%, which was superior to chlordimeform (22.00%) but significantly lower than that of the commercial insecticide fipronil (88.00%). Preliminary SAR analysis: Retaining the benzene ring’s 2-methyl group and replacing the 4-chloro with fluorine, cyano, phenoxy, or benzyloxy enhanced the insecticidal activity; replacing benzene with heterocycles/fused heterocycles (except pyrazole-substituted <strong>4m</strong>) reduced the insecticidal activity. This study provides theoretical insights and candidate compounds for novel amidine-based insecticides.</div></div>","PeriodicalId":22119,"journal":{"name":"Synthetic Communications","volume":"56 7","pages":"Pages 525-536"},"PeriodicalIF":1.8,"publicationDate":"2026-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147707185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Electrochemical difunctionalization of alkenes via chemoselective oxo-amination to access α-sulfonylamino ketones","authors":"Yu Liu (Validation) ,&nbsp;Xiufeng Zhang (Formal analysis) ,&nbsp;Zhangyang Shen (Data curation) ,&nbsp;Xinyu Bu (Investigation) ,&nbsp;Yingying Deng (Methodology) ,&nbsp;Shengjun Li (Investigation) ,&nbsp;Huanwen Chen (Supervision) ,&nbsp;Pingnan Wan (Data curation) ,&nbsp;Yang Wan (Supervision) ,&nbsp;Sheng Zhang Liu (Writing – original draft Writing – review & editing)","doi":"10.1080/00397911.2026.2646265","DOIUrl":"10.1080/00397911.2026.2646265","url":null,"abstract":"<div><div>The oxo-amination of alkenes represents a straightforward route to prepare α-amino ketones, which are valuable scaffolds for organic synthesis. The development of a practical method for this transformation is therefore actively being pursued. Herein, we report an electro-oxidative oxo-amination of alkenes that employs readily available O₂ as a green oxygen source, eliminating the need for an external oxidant. This strategy features a simple setup, broad substrate scope, mild conditions, and high atom economy, enabling the conversion of amines into diversely functionalized α-sulfonylamino ketones. Furthermore, the method was applied to the synthesis of the natural product halostachine. Mechanistic studies suggest a pathway initiated by the electrochemical generation of nitrogen-centred radicals, which subsequently add to alkenes.</div></div>","PeriodicalId":22119,"journal":{"name":"Synthetic Communications","volume":"56 7","pages":"Pages 513-524"},"PeriodicalIF":1.8,"publicationDate":"2026-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147707187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Design and synthesis of benzofuran–pyrazole–triazole hybrids via click chemistry: Antimicrobial, anticancer, ADMET, docking, and DFT studies","authors":"Ila M. Ram (Conceptualization Data curation Resources Writing – original draft) ,&nbsp;Jay B. Maheta (Data curation Resources Writing – review & editing) ,&nbsp;Darshna K. Lakhnotra (Data curation Resources) ,&nbsp;Nargis H. Shaikh (Formal analysis Resources) ,&nbsp;Viral U. Majethiya (Resources) ,&nbsp;Yogesh O. Bhola (Software Supervision Writing – review & editing)","doi":"10.1080/00397911.2026.2642776","DOIUrl":"10.1080/00397911.2026.2642776","url":null,"abstract":"<div><div>Ten novel benzofuran–pyrazole–triazole hybrid compounds <strong>(10a–j)</strong> were synthesized via multistep methodology and characterized by ¹H NMR,¹³ CMR, IR, and mass spectrometry. Molecular docking studies against epidermal growth factor receptor (EGFR) (1M17) and the fibrinogen-binding domain (4NYT) revealed compounds <strong>10i</strong> and <strong>10j</strong> as promising EGFR inhibitors, with binding scores of −6.22 and −6.21 kcal/mol, respectively, which are superior to that of combretastatin-A4 (−6.15 kcal/mol). Against the fibrinogen-binding domain, compounds <strong>10d</strong> and <strong>10h</strong> showed excellent binding (−8.65 kcal/mol each) compared to ciprofloxacin (−7.49 kcal/mol). Anticancer evaluation demonstrated compound <strong>10c</strong> as the most potent with IC₅₀ values of 2.18–2.50 µM against HT-29, MCF-7, and A549 cell lines. Compound <strong>10j</strong> also exhibited significant activity (IC₅₀: 2.61–3.82 µM) across multiple cancer cell lines. Antimicrobial screening revealed that compound 10h exhibited broad-spectrum activity (minimum inhibitory concentration [MIC]: 0.0157–0.0628 mg ml⁻¹), while compounds <strong>10i</strong> and <strong>10j</strong> showed efficacy comparable to that of ciprofloxacin. Density functional theory (DFT) calculations (B3LYP/6–311++G(d,p)) indicated superior thermodynamic stability for compound <strong>10h</strong> over <strong>10j</strong>, absorption, distribution, metabolism, and excretion (ADMET) analysis confirmed acceptable drug-like properties with minimal Lipinski violations. These benzofuran–pyrazole–triazole hybrids represent promising scaffolds for the development of anticancer and antimicrobial drugs.</div></div>","PeriodicalId":22119,"journal":{"name":"Synthetic Communications","volume":"56 7","pages":"Pages 537-564"},"PeriodicalIF":1.8,"publicationDate":"2026-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147707184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An isoxazole strategy for the synthesis of curcumin and demethoxycurcumin","authors":"Mirai Kato (Investigation Writing – original draft) ,&nbsp;Kyosuke Sugihara (Investigation) ,&nbsp;Aki Tanaka (Investigation Writing – review & editing) ,&nbsp;Rina Tanaka (Investigation) ,&nbsp;Hitoshi Abe (Conceptualization Project administration Supervision Writing – review & editing)","doi":"10.1080/00397911.2026.2649255","DOIUrl":"10.1080/00397911.2026.2649255","url":null,"abstract":"<div><div>Curcumin and demethoxycurcumin were synthesized <em>via</em> an isoxazole-masking strategy. A 3,5-disubstituted isoxazole, obtained by [3 + 2] cycloaddition of a nitrile oxide and an alkyne, underwent mild reductive <em>N</em>-<em>O</em> cleavage to reveal the β-diketone core in good yield.</div></div>","PeriodicalId":22119,"journal":{"name":"Synthetic Communications","volume":"56 7","pages":"Pages 565-572"},"PeriodicalIF":1.8,"publicationDate":"2026-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147707186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}