Pyrazole-Sulfone hybridization via silver-catalyzed regioselective aza-Michael addition of pyrazoles to vinyl sulfones: Synthesis of N-sulfonylethylated pyrazoles

IF 1.8 3区化学 Q3 CHEMISTRY, ORGANIC

Synthetic Communications Pub Date : 2025-06-12 DOI:10.1080/00397911.2025.2518387

Xue Zhang (Conceptualization Writing – original draft Writing – review & editing) , Yang Song (Data curation Formal analysis) , Yutong Peng (Investigation) , Dakang Zhu (Methodology) , Wanxin Zhang (Investigation) , Haifeng Yu (Conceptualization) , Xiaobo Zhao (Project administration)

引用次数: 0

Abstract

In this research, the facile pyrazole-sulfone hybridization via Ag₂CO₃-catalyzed aza-Michael addition of pyrazoles to vinyl sulfones has been developed. The methodology offers an efficient and regioselective synthesis of N-sulfonylethylated pyrazoles as an important subset of pyrazole-sulfone hybrids and it featured mild reaction conditions, excellent yields and high regioselectivity (reaching the highest N¹/N² ratio of 25:1).

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银催化吡唑与乙烯基砜的区域选择性杂化：n -磺基乙基化吡唑的合成

在本研究中，通过ag2co3催化aza-Michael加成吡唑与乙烯基砜进行了吡唑与砜的简单杂化。n -磺基乙基化吡唑是吡唑-砜杂化物的重要组成部分，该方法具有反应条件温和、收率高、区域选择性高（N1/N2比最高可达25:1）等特点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Synthetic Communications 化学-有机化学

CiteScore

4.40

自引率

4.80%

发文量

156

审稿时长

4.3 months

期刊介绍： Synthetic Communications presents communications describing new methods, reagents, and other synthetic work pertaining to organic chemistry with sufficient experimental detail to permit reported reactions to be repeated by a chemist reasonably skilled in the art. In addition, the Journal features short, focused review articles discussing topics within its remit of synthetic organic chemistry.