A sustainable approach for one-pot, multicomponent synthesis of 2-amino-4H-chromenes using bleach

IF 1.8 3区化学 Q3 CHEMISTRY, ORGANIC

Synthetic Communications Pub Date : 2025-06-21 DOI:10.1080/00397911.2025.2521701

Nikita Shinde (Methodology Project administration Writing – original draft) , Lina Jadhav (Investigation Validation) , Mayuri B. Thorat (Writing – review & editing), Krantisagar More (Resources Supervision) , Yatin U. Gadkari (Conceptualization Methodology Project administration Writing – review & editing)

引用次数: 0

Abstract

The present study outlines an efficient and straightforward approach for synthesizing amino-chromenes via multicomponent reaction from aldehyde, dimedone and malononitrile using aqueous sodium hypochlorite (10–13%) (bleach) as a catalyst under neat conditions. Sodium hypochlorite was identified as an effective catalyst, facilitating the reaction with minimal catalyst loading and yielding high product output. The developed protocol demonstrates significant improvements, featuring simplified work-up, reduced energy consumption, shortened reaction times, and an eco-friendly profile with favorable E-factors (3.5), Eco-scale scores (97), and Process mass intensity (6.3).

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漂白剂一锅多组分合成2-氨基- 4h -铬的可持续方法

本研究概述了一种在整洁条件下，以次氯酸钠（10-13%）（漂白剂）为催化剂，以醛、二美酮和丙二腈为原料，通过多组分反应合成氨基铬的高效、直接的方法。次氯酸钠是一种有效的催化剂，催化剂负荷小，产率高。开发的方案显示出显着的改进，其特点是简化了工作，降低了能耗，缩短了反应时间，并且具有良好的e因子（3.5），生态量表得分（97）和工艺质量强度（6.3）的生态友好型特征。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Synthetic Communications 化学-有机化学

CiteScore

4.40

自引率

4.80%

发文量

156

审稿时长

4.3 months

期刊介绍： Synthetic Communications presents communications describing new methods, reagents, and other synthetic work pertaining to organic chemistry with sufficient experimental detail to permit reported reactions to be repeated by a chemist reasonably skilled in the art. In addition, the Journal features short, focused review articles discussing topics within its remit of synthetic organic chemistry.