Synthetic Communications最新文献_第10页

A simple, facile and greener route to thiazolo[3,2-c]pyrimidinones in semi-aqueous medium and their antibacterial properties 在半水介质中制备噻唑并[3,2-c]嘧啶酮及其抗菌特性的简单、方便和绿色途径

IF 2.1 3区化学

Synthetic Communications Pub Date : 2024-02-08 DOI: 10.1080/00397911.2024.2314597

Kübra Uysal , Muhammet Yıldırım , Hamza Karakuş , Arzu Yıldırım

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Synthesis of allomaltol containing terarylenes with imidazole N-oxides bridge fragment 含咪唑 N-氧化桥片段的异麦芽酮醇萜烯的合成

IF 2.1 3区化学

Synthetic Communications Pub Date : 2024-02-01 DOI: 10.1080/00397911.2024.2310522

Constantine V. Milyutin , Andrey N. Komogortsev , Boris V. Lichitsky , Valeriya G. Melekhina

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Novel organic–inorganic hybrid dimethyltin(IV) complexes of heterocyclic carboxylic acid and N-phthaloyl amino acids: Design, synthesis, spectroscopic characterization, DFT calculations and their anti-oxidant potential 杂环羧酸和 N-邻苯二甲酰氨基酸的新型有机-无机杂化二甲基锡（IV）配合物：设计、合成、光谱表征、DFT 计算及其抗氧化潜力

IF 2.1 3区化学

Synthetic Communications Pub Date : 2024-01-29 DOI: 10.1080/00397911.2024.2306641

Ankur M. Kumar , Suchitra Budania , Asha Jain

{"title":"Novel organic–inorganic hybrid dimethyltin(IV) complexes of heterocyclic carboxylic acid and N-phthaloyl amino acids: Design, synthesis, spectroscopic characterization, DFT calculations and their anti-oxidant potential","authors":"Ankur M. Kumar , Suchitra Budania , Asha Jain","doi":"10.1080/00397911.2024.2306641","DOIUrl":"https://doi.org/10.1080/00397911.2024.2306641","url":null,"abstract":"<div>Four new organic–inorganic hybrid dimethyltin(IV) complexes (1–4) having general formula Me2SnAL which were generated by the reaction of dimethyltin(IV) dichloride with sodium salts of indole-3-acetic acid (AH) and flexible N-phthaloyl amino acids (LH) in 1:1:1 molar ratio in refluxing dry THF. The plausible structure of newly generated complexes has been elucidated on the basis of spectroscopic [IR, NMR (1H,13C,119Sn), HRMS] studies. The suggested five coordinated geometry of the hybrid dimethyltin(IV) complexes have been further supported by computational calculations using density functional theory (DFT). DFT calculations were carried out using B3LYP/6-31G* functional basis set. DFT calculations furnish an insight into the optimized geometry, optimized energy, stability, global reactivity descriptors and frontier molecular orbital (FMO) analysis of newly synthesized organic–inorganic hybrid dimethyltin(IV) complexes. These newly synthesized complexes were also evaluated for their anti-radical activity by DPPH free radical scavenging assay. All the dimethyltin(IV) complexes acted as efficient radical scavengers.</div>","PeriodicalId":22119,"journal":{"name":"Synthetic Communications","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139738715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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P4O10/TfOH-mediated metal-free synthesis of 4-hydroxycoumarins and a one-pot strategy to build their hybrids P4O10/TfOH 介导的 4-羟基香豆素的无金属合成及其杂化的一步法策略

IF 2.1 3区化学

Synthetic Communications Pub Date : 2024-01-27 DOI: 10.1080/00397911.2024.2306610

G. D. Kotkar , S. G. Tilve

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Friedländer reactions for novel annulated pyridotriazolothiazolopyridines: Synthetic approaches and antimicrobial evaluation 新型环状吡啶三唑并噻唑吡啶的 Friedländer 反应：合成方法和抗菌评估

IF 2.1 3区化学

Synthetic Communications Pub Date : 2024-01-22 DOI: 10.1080/00397911.2024.2306926

Youssef A Alnamer , Magdy A Ibrahim

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Asymmetric aza-Henry reaction of BOC-protected imines with zinc-FAM catalyst 锌-FAM 催化剂与 BOC 保护亚胺的不对称氮杂亨利反应

IF 2.1 3区化学

Synthetic Communications Pub Date : 2024-01-16 DOI: 10.1080/00397911.2024.2303054

Nurzhan Beksultanova , Özdemir Doğan

引用次数: 0

Design, synthesis, anticancer evaluation and molecular docking studies of 1,2,4-oxadiazole incorporated indazole-isoxazole derivatives 1,2,4-恶二唑吲哚-异恶唑衍生物的设计、合成、抗癌评价及分子对接研究

IF 2.1 3区化学

Synthetic Communications Pub Date : 2024-01-02 DOI: 10.1080/00397911.2023.2282599

Jesse Lingam , Bijaya Ketan Sahoo , Bala Divya Mallavarapu , Reddymasu Sreenivasulu

{"title":"Design, synthesis, anticancer evaluation and molecular docking studies of 1,2,4-oxadiazole incorporated indazole-isoxazole derivatives","authors":"Jesse Lingam , Bijaya Ketan Sahoo , Bala Divya Mallavarapu , Reddymasu Sreenivasulu","doi":"10.1080/00397911.2023.2282599","DOIUrl":"10.1080/00397911.2023.2282599","url":null,"abstract":"<div>A new series of 1,2,4-oxadiazole incorporated indazole-isoxazole (12a–j) derivatives were designed, synthesized and confirmed their structures by 1HNMR, 13CNMR and mass spectral analysis. Further, all compounds were evaluated for their anticancer activity against a panel of human cell lines like breast cancer (MCF-7), lung cancer (A549), prostate cancer (DU-145) and breast cancer (MDA MB-231) by using MTT assay. The etoposide used as a reference drug and the results were expressed with IC50 (µM). Most of the compounds were showed good to moderate activity with respective cell lines. Among them, compounds 12b, 12e, 12 g, 12h and 12i have exhibited more potent activity as compared with the reference drug etoposide. In which one of the compound 12i has showed most significant activity. Molecular docking studies were carried out using PyRx tool and visualized through Chimera and Pymol visualization tools, revealed that the interactions between the active site of the tubulin with the selected compound 12i exhibited good interactions with the active site amino acids. These findings suggested that the 12i compound acts as a potential binder to the tubulin complex. These results revealed that the selected synthesized compounds were used in anticancer therapies.</div>","PeriodicalId":22119,"journal":{"name":"Synthetic Communications","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138496820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Base promoted coupling of α-ketoacids and 2-substituted aromatic amines: Green synthesis of diverse benzoxazoles, benzothiazoles, quinoxalinones and benzoxazinones and its practical application 碱促α-酮酸与2-取代芳胺的偶联:多种苯并恶唑、苯并噻唑、喹草啉酮和苯并恶唑酮的绿色合成及其实际应用

IF 2.1 3区化学

Synthetic Communications Pub Date : 2024-01-02 DOI: 10.1080/00397911.2023.2280599

Sivagami Mathavan , Subburethinam Ramesh , Rajesh B. R. D. Yamajala

引用次数: 0

An efficient, concise synthetic approach to γ-aminobutyric acid (GABA) derivatives bearing bicyclo[2.2.2]octane and bicyclo[2.2.1]heptane rings 含双环[2.2.2]辛烷和双环[2.2.1]庚烷的γ-氨基丁酸(GABA)衍生物的高效、简明合成方法

IF 2.1 3区化学

Synthetic Communications Pub Date : 2024-01-02 DOI: 10.1080/00397911.2023.2284348

Wen Luo , Xinqiang Cheng , Xinyuan Zhu , Yong Li , Yongjia Liu , Wenqian Huang , Yan Li , Guilong Zhao

{"title":"An efficient, concise synthetic approach to γ-aminobutyric acid (GABA) derivatives bearing bicyclo[2.2.2]octane and bicyclo[2.2.1]heptane rings","authors":"Wen Luo , Xinqiang Cheng , Xinyuan Zhu , Yong Li , Yongjia Liu , Wenqian Huang , Yan Li , Guilong Zhao","doi":"10.1080/00397911.2023.2284348","DOIUrl":"10.1080/00397911.2023.2284348","url":null,"abstract":"<div>An efficient, concise 5-step synthetic approach to γ-aminobutyric acid (GABA) derivatives bearing bridged bicyclo[2.2.2]octane and bicyclo[2.2.1]heptane rings was developed, which consists of Diels-Alder cycloaddition to construct the bridged bicyclic rings with a nitrile functionality, hydrogenation, LDA-mediated SN2 alkylation to introduce acetate moiety at the α-position of nitrile, reduction of the nitrile functionality to amino group followed by intramolecular formation of lactam and finally acidic hydrolysis of lactam to give the desired GABA derivatives (1 and 19 as HBr salts). The reaction conditions of Diels-Alder cycloaddition and LDA-mediated SN2 alkylation were intensively optimized to improve the yields. The stereochemistry of the SN2 reaction involved in the bicyclo[2.2.1]heptane ring system was unambiguously elucidated by single-crystal X-ray diffraction. This synthetic approach possesses advantages of less reaction steps, high overall yields and avoidance of toxic reagents, and may find wide applications in the synthesis of other GABA derivatives with similar bicyclic or polycyclic rings.</div>","PeriodicalId":22119,"journal":{"name":"Synthetic Communications","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138496819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recent insights into synthesis, biological activities, structure activity relationship and molecular interactions of thiazolidinone hybrids: A systematic review 关于噻唑烷酮杂交化合物的合成、生物活性、结构活性关系和分子相互作用的最新见解：系统综述

IF 2.1 3区化学

Synthetic Communications Pub Date : 2024-01-02 DOI: 10.1080/00397911.2023.2269582

Sabnam Parveen , Ritchu Babbar , Vishnu Nayak Badavath , Suman Kumar Nath , Sourabh Kumar , Ravi Rawat , Sridevi Chigurupati , Rohini Karunakaran , Pranay Wal , Monica Gulati , Tapan Behl

{"title":"Recent insights into synthesis, biological activities, structure activity relationship and molecular interactions of thiazolidinone hybrids: A systematic review","authors":"Sabnam Parveen , Ritchu Babbar , Vishnu Nayak Badavath , Suman Kumar Nath , Sourabh Kumar , Ravi Rawat , Sridevi Chigurupati , Rohini Karunakaran , Pranay Wal , Monica Gulati , Tapan Behl","doi":"10.1080/00397911.2023.2269582","DOIUrl":"10.1080/00397911.2023.2269582","url":null,"abstract":"<div>The thiazolidinone component is a specialized frame exhibiting various biological reactions comprising analgesic, hypnotic, antiviral, anticancer, antitubercular, and many more. As the target scaffold for biological investigations, current category of heterocycles has been created by researchers using a number of fundamental techniques, as well as sophisticated routes. Recent research has focused heavily on 1,3-thiazolidin-4-one heterocyclic nuclei, which contain electron configurations at the tetrahedral site and at positions 1 and 3, sulfur and nitrogen atoms, respectively. The goal of the current review is to summarize the published work concerning the chemistry and pharmacological properties of thiazolidinone derivatives over the past few years. This is executed by characterizing thiazolidinone derivatives with various pharmacological activities using structural substitution patterns around the thiazolidinone moiety as the basis for the SAR study and their interactions with various proteins. This review also summarizes current developments in the chemical, molecular and biological activities of thiazolidinones.</div>","PeriodicalId":22119,"journal":{"name":"Synthetic Communications","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136263566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0