Synthetic Communications最新文献_第10页

Synthesis and characterization of alumina supported molybdosilicic acid (SiMo12/Al2O3): Efficient solid acid catalyst for the synthesis of pyranopyrazole derivatives 氧化铝支撑的钼硅酸（SiMo 12 /Al 2 O 3）的合成与表征：合成吡喃并唑衍生物的高效固体酸催化剂

IF 2.1 3区化学

Synthetic Communications Pub Date : 2024-05-18 DOI: 10.1080/00397911.2024.2345380

Shital B. Sukale , Dipak S. Aher , Laxmikant D. Chavan , Kiran R. Khillare , Sunil G. Shankarwar

{"title":"Synthesis and characterization of alumina supported molybdosilicic acid (SiMo12/Al2O3): Efficient solid acid catalyst for the synthesis of pyranopyrazole derivatives","authors":"Shital B. Sukale , Dipak S. Aher , Laxmikant D. Chavan , Kiran R. Khillare , Sunil G. Shankarwar","doi":"10.1080/00397911.2024.2345380","DOIUrl":"10.1080/00397911.2024.2345380","url":null,"abstract":"<div>A series of highly reusable heterogeneous catalysts (10-40 wt.% SiMo12/Al2O3), consisting of molybdosilicic acid (SiMo12) impregnated on alumina (Al2O3) support was synthesized by the wetness impregnation method. The physicochemical properties of synthesized catalyst were studied using FT-IR, XRD, SEM, EDX, TEM, BET and TG-DTA analysis techniques. The study proves that the synthesized SiMo12 catalyst efficiently incorporated on the surface of Al2O3. The catalytic activity of prepared catalyst was investigated for the synthesis of pyranopyrazole(6-amino-4-phenyl-3-methyl-2,4-dihydropyrano[2,3-c]pyrazole-5carbonitrile) via cyclocondensation reaction of aldehydes, malononitrile, hydrazine hydrate and ethyl-acetoacetate under solvent-free conditions. Among different catalysts, 30% SiMo12 supported on to Al2O3 showed the highest catalytic activity. High yield, shorter reaction time, operational simplicity, solvent-free conditions and reusability of the catalyst are the distinct features of this protocol.</div>","PeriodicalId":22119,"journal":{"name":"Synthetic Communications","volume":"54 10","pages":"Pages 826-842"},"PeriodicalIF":2.1,"publicationDate":"2024-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140988661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Novel annulated chromeno[3',2':5,6]pyrido[2,3-d][1,3,4]thiadiazolo[3,2-a] pyrimidines and chromeno[3'',2'':5',6']pyrido[2',3':4,5]pyrimido[2,1-b][1,3,4] thiadiazines: Synthetic approaches and antimicrobial efficiency 新型环状铬[3',2':5,6]吡啶并[2,3- d ][1,3,4]噻二唑并[3,2- a ]嘧啶和铬[3'',2'':5',6']吡啶并[2',3':4,5]嘧啶并[2,1- b ][1,3,4]噻二嗪：合成方法和抗菌效率

IF 2.1 3区化学

Synthetic Communications Pub Date : 2024-05-18 DOI: 10.1080/00397911.2024.2346565

F. M. Alshareef , Zahra M. Alamshany , Sami A. Al-Harbi , Esam S. Allehyani , Magdy A. Ibrahim

{"title":"Novel annulated chromeno[3',2':5,6]pyrido[2,3-d][1,3,4]thiadiazolo[3,2-a] pyrimidines and chromeno[3'',2'':5',6']pyrido[2',3':4,5]pyrimido[2,1-b][1,3,4] thiadiazines: Synthetic approaches and antimicrobial efficiency","authors":"F. M. Alshareef , Zahra M. Alamshany , Sami A. Al-Harbi , Esam S. Allehyani , Magdy A. Ibrahim","doi":"10.1080/00397911.2024.2346565","DOIUrl":"10.1080/00397911.2024.2346565","url":null,"abstract":"<div>The current study includes synthetic approaches for some linear heterocyclic compounds containing chromone moiety. Chromenopyridopyrimidine bearing amino-thione functions 4 was efficiently synthesized starting from 6,8-dimethylchromone-3-carbonitrile (1). The novel chromenopyridothiadiazolopyrimidines were synthesized through condensation of the key precursor 4 with some mono-electrophilic reagents. In addition, heteroannulated chromenopyridopyrimidothiadiazines were synthesized through condensation of compound 4 with some α-halogenated carbonyl reagents. The synthesized products were examined for their antimicrobial efficiency appearing remarkable activity against the inspected microorganisms especially compounds 7, 12 and 14. The synthesized products were inferred using analytical and spectral data.</div>","PeriodicalId":22119,"journal":{"name":"Synthetic Communications","volume":"54 10","pages":"Pages 843-852"},"PeriodicalIF":2.1,"publicationDate":"2024-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141050554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An overall development on catalytic applications of potassium phthalimide (PPI) and potassium phthalimide-N-oxyl (POPINO) in organic synthesis 邻苯二甲酰亚胺钾（PPI）和邻苯二甲酰亚胺-N-氧乙基钾（POPINO）在有机合成中的催化应用的总体发展情况

IF 2.1 3区化学

Synthetic Communications Pub Date : 2024-04-24 DOI: 10.1080/00397911.2024.2342316

Urvi J. Khengar , Dharti R. Bhandari , Rajesh H. Vekariya , Jinal A. Gajjar

引用次数: 0

Asymmetric Diels–Alder reaction of chalcone and isoprene mediated by titanium-based complexes 钛基络合物介导的查尔酮和异戊二烯的不对称 Diels-Alder 反应

IF 2.1 3区化学

Synthetic Communications Pub Date : 2024-04-17 DOI: 10.1080/00397911.2024.2324002

Chun Keng Thy , Yean Kee Lee , Iskandar Abdullah , Noorsaadah Abd Rahman , Chin Fei Chee

引用次数: 0

Polyethyleneimine-immobilized CoCl2 nanoparticles: Synthesis, characterization, application as a new efficient and reusable nanocomposite catalyst for one-step transesterification reaction 聚乙烯亚胺固定的 CoCl2 纳米颗粒：一步法酯交换反应的新型高效可重复使用纳米复合催化剂的合成、表征和应用

IF 2.1 3区化学

Synthetic Communications Pub Date : 2024-04-17 DOI: 10.1080/00397911.2024.2328287

Tahereh Darvishi , Sedigheh Azadi , Nooredin Goudarzian

{"title":"Polyethyleneimine-immobilized CoCl2 nanoparticles: Synthesis, characterization, application as a new efficient and reusable nanocomposite catalyst for one-step transesterification reaction","authors":"Tahereh Darvishi , Sedigheh Azadi , Nooredin Goudarzian","doi":"10.1080/00397911.2024.2328287","DOIUrl":"10.1080/00397911.2024.2328287","url":null,"abstract":"<div>Polyethyleneimine-supported cobalt (II) chloride as a novel polymeric nanocomposite acidic catalyst for the one-stage transesterification reaction of ethyl acetate with various alcohols is reported. The catalyst was characterized by Fourier transform infrared spectroscopy, X-ray powder diffraction, transmission electron microscopy, scanning electron microscopy, dynamic light scattering technique, and thermal gravimetric analysis. Furthermore, inductively coupled plasma and atomic absorption spectroscopy were used to determine the quantity of Cobalt nanoparticles in the catalyst. By adding the catalyst (0.10 g, 0.20 mol%) and n-hexane/chloroform (5.0 cm3) as solvent under reflux conditions, the studies demonstrated successful transesterification reactions with excellent yields (80–98%) and short reaction times (0.50–1.30 h) using various substrates on the scale of 1.0 mmol. Seven consecutive reactions could be performed on the catalyst without significantly decreasing its activity. The most noteworthy aspects of this process are its low cost, safety, and environmental friendliness due to the catalyst’s non-toxicity, straightforward operation, and effective outcomes.</div>","PeriodicalId":22119,"journal":{"name":"Synthetic Communications","volume":"54 8","pages":"Pages 672-693"},"PeriodicalIF":2.1,"publicationDate":"2024-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140199332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synthesis of 1H-benzimidazoles via the condensation of o-phenylenediamines with DMF promoted by organic acid under microwave irradiation 微波辐照下有机酸促进邻苯二胺与 DMF 缩合合成 1H 苯并咪唑

IF 2.1 3区化学

Synthetic Communications Pub Date : 2024-04-17 DOI: 10.1080/00397911.2024.2324456

Wenjuan Li , Xiao Li , Hailong Hong , Ruijun Xie , Ning Zhu

引用次数: 0

Novel pyrano[2,3-c]pyrazolopyrimidines as promising anticancer agents: Design, synthesis, and cell cycle arrest of HepG2 cells at S phase 新型吡喃并[2,3-c]吡唑嘧啶作为有前途的抗癌剂：设计、合成和抑制 S 期 HepG2 细胞的细胞周期

IF 2.1 3区化学

Synthetic Communications Pub Date : 2024-04-17 DOI: 10.1080/00397911.2024.2327047

David S. A. Haneen , Mohamed H. Hekal , Wael S. I. Abou-Elmagd , Wael M. El-Sayed

{"title":"Novel pyrano[2,3-c]pyrazolopyrimidines as promising anticancer agents: Design, synthesis, and cell cycle arrest of HepG2 cells at S phase","authors":"David S. A. Haneen , Mohamed H. Hekal , Wael S. I. Abou-Elmagd , Wael M. El-Sayed","doi":"10.1080/00397911.2024.2327047","DOIUrl":"10.1080/00397911.2024.2327047","url":null,"abstract":"<div>The poor selectivity, significant toxicity, high cost, and emergence of resistance of conventional chemotherapies are driving motive for the ongoing search for novel anticancer agents. New pyrano[2,3-c]pyrazolopyrimidines were synthesized and examined as antiproliferative agents, and the possible molecular mechanism(s) of action were explored. The mass and elemental analyses, alongside the IR,1H, and 13C NMR spectra, confirmed the proposed structures of the obtained compounds. Derivatives 4 and 7 demonstrated the best antiproliferative profile against HepG2 cancer cells at 4 µM, with a high selectivity index of ∼7–9 folds. They increased the S phase cell population by 51% and 40% and caused a 5- and 11-fold increase in the p21 protein. Compound 7 was superior in inhibiting HepG2 cell migration and delayed wound healing, reducing migration rates by 55% and 90%, respectively. Future studies on the pharmacokinetics, pharmacodynamics, antimetastatic, and antitumor activities in animal models would be a robust advance.</div>","PeriodicalId":22119,"journal":{"name":"Synthetic Communications","volume":"54 8","pages":"Pages 655-671"},"PeriodicalIF":2.1,"publicationDate":"2024-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140125388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Review of synthesis process of benzimidazole-heterocycle hybrid compounds 苯并咪唑杂环化合物合成工艺综述

IF 2.1 3区化学

Synthetic Communications Pub Date : 2024-04-17 DOI: 10.1080/00397911.2024.2316718

Abouelhaoul El Alami , Hamid Sdassi , Said Bouzikri

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The Lacunae identified in processing, analyzing and finding means of catalyst free Oxone mediated through C-3 oxidation of N-alkyl quinoxalin-2(1h)-one 在处理、分析和寻找通过 C-3 氧化 N-烷基喹喔啉-2(1h)-酮介导的无催化剂 Oxone 的方法过程中发现的缺陷

IF 2.1 3区化学

Synthetic Communications Pub Date : 2024-04-17 DOI: 10.1080/00397911.2024.2329245

Vikas S. Patil , Gayathri Chunduri , Balaram Kiran Avasarala , Gangaiah L , Pasham Yoganand , Kola Srinivas , Murali Koparala , Nagaraju Devunuri

{"title":"The Lacunae identified in processing, analyzing and finding means of catalyst free Oxone mediated through C-3 oxidation of N-alkyl quinoxalin-2(1h)-one","authors":"Vikas S. Patil , Gayathri Chunduri , Balaram Kiran Avasarala , Gangaiah L , Pasham Yoganand , Kola Srinivas , Murali Koparala , Nagaraju Devunuri","doi":"10.1080/00397911.2024.2329245","DOIUrl":"10.1080/00397911.2024.2329245","url":null,"abstract":"<div>A catalyst free oxone mediated synthesizing N-alkyl 1, 4-dihydroquinoxaline-2,3-dione has been developed by oxidation of the N-alkyl quinoxalin-2(1H)-one. The developed method is a novel, safest, cost-effective, industrially viable method and applicable for N-substituted and without substitution of 1,4-dihydroquinoxaline-2,3-dione. Consequently, the process is applicable to a broad spectrum of functionality. The reaction can be performed in all organic solvents without any further heating with an extended time and without generating side products. This novel synthetic methodology using Oxone is believed to be the shortest and most efficient to prepare various key intermediates which can be used for further derivatization to make the different biologically active molecules, the key feature of this methodology is not solvent specific, all organic solvents giving the optimum purity and quality using the same reaction condition.</div>","PeriodicalId":22119,"journal":{"name":"Synthetic Communications","volume":"54 8","pages":"Pages 694-708"},"PeriodicalIF":2.1,"publicationDate":"2024-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140147791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

KHSO4 promoted practical synthesis of quinazolin-4(3H)-ones and benzothiadiazine 1,1-dioxides KHSO4 促进喹唑啉-4(3H)-酮和苯并噻二嗪 1,1-二氧化物的实用合成

IF 2.1 3区化学

Synthetic Communications Pub Date : 2024-04-04 DOI: 10.1080/00397911.2024.2335638

Jiecheng Zheng , Feng Gong , Wei Wang , Yue Wu , Dezhang Zhao , Tianyuan Zhang , WenWen Yang , Zongjie Gan

引用次数: 0