芳香羧酸的无过渡金属和耐溶剂脱羧碘化

IF 1.8 3区化学 Q3 CHEMISTRY, ORGANIC

Synthetic Communications Pub Date : 2025-01-02 DOI:10.1080/00397911.2024.2428650

Cheng-Yan Wu , Xi Zhang , Tian-Yi Zhang , Zhong-Lin Lu

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引用次数: 0

摘要

目前的脱羧卤化方法通常需要昂贵或有毒的过渡金属催化剂，并且溶剂相容性有限。在此，我们报告了一种新的无过渡金属和耐溶剂的脱羧碘化方法，即在磷酸钾存在下使用一氯化碘，这种方法对现成的芳基和杂芳基羧酸有效，并且可以在各种溶剂中进行，包括水。

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Transition-metal-free and solvent-tolerant decarboxylative iodination of aromatic carboxylic acids

Current decarboxylative halogenation methods typically require expensive or toxic transition metal catalysts and have limited solvent compatibility. Herein, we report a novel transition-metal-free and solvent-tolerant decarboxylative iodination method by using iodine monochloride in the presence of potassium phosphate, which are effective to readily available aryl and heteroaryl carboxylic acids, and can be executed in a variety of solvents, including water.

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来源期刊

Synthetic Communications 化学-有机化学

CiteScore

4.40

自引率

4.80%

发文量

156

审稿时长

4.3 months

期刊介绍： Synthetic Communications presents communications describing new methods, reagents, and other synthetic work pertaining to organic chemistry with sufficient experimental detail to permit reported reactions to be repeated by a chemist reasonably skilled in the art. In addition, the Journal features short, focused review articles discussing topics within its remit of synthetic organic chemistry.