铁（II）催化醋酸酮肟与原甲酸三乙酯的环化：一种容易得到对称吡啶的方法

IF 1.8 3区化学 Q3 CHEMISTRY, ORGANIC

Synthetic Communications Pub Date : 2024-12-01 DOI:10.1080/00397911.2024.2421364

Kotyada Satishkumar , Podugu Rajitha Lakshmi , Yettula Kumari , Voosala Christopher , Vidavalur Siddaiah

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引用次数: 0

摘要

在氮环境下，以乙酸酮肟和原甲酸三乙酯为原料，在120℃的DMF中，用铁（II）催化合成了一种简单高效的对称吡啶。在该策略中，原甲酸三乙酯作为C1碳源具有重要的作用，值得注意。该工艺的其他优点包括产率高、官能团耐受性高、催化剂成本低和避免使用危险化学品。

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Iron (II) catalyzed cyclization of ketoxime acetates with triethyl orthoformate: An easy access to symmetrical pyridines

A simple and efficient iron (II) catalyzed approach to the synthesis of symmetrical pyridines has been demonstrated using ketoxime acetates and triethyl orthoformate in DMF at 120 °C under nitrogen environment. In this strategy, significantly, triethyl orthoformate functions as C1 carbon source and which is noteworthy. Other benefits of this process include good yields, high functional group tolerance, low cost of catalyst and avoiding of use of hazardous chemicals.

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来源期刊

Synthetic Communications 化学-有机化学

CiteScore

4.40

自引率

4.80%

发文量

156

审稿时长

4.3 months

期刊介绍： Synthetic Communications presents communications describing new methods, reagents, and other synthetic work pertaining to organic chemistry with sufficient experimental detail to permit reported reactions to be repeated by a chemist reasonably skilled in the art. In addition, the Journal features short, focused review articles discussing topics within its remit of synthetic organic chemistry.