An efficient and practical synthesis of ferroptosis inducer erastin

IF 1.8 3区化学 Q3 CHEMISTRY, ORGANIC

Synthetic Communications Pub Date : 2024-11-01 DOI:10.1080/00397911.2024.2423363

Xinxin Cui , Chenghan Zhuang , Siyu Liang , Xingxian Zhang

引用次数: 0

Abstract

Erastin, a classic ferroptosis inducer, mediates ferroptosis through various molecular pathways. A highly efficient and convenient synthesis of erastin has been developed, starting from 2-nitrobenzoic acid through 7 steps in an overall yield of 21.6%. This synthesis approach features the efficient construction of the key quinazolinone core and highly selective bromination.

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一种高效实用的铁色素沉着诱导剂麦拉宁合成方法

厄拉斯汀是一种典型的铁突变诱导剂，通过多种分子途径介导铁突变。从 2-硝基苯甲酸开始，经过 7 个步骤，我们开发出了一种高效便捷的厄拉斯汀合成方法，总收率达 21.6%。这种合成方法的特点是高效构建关键的喹唑啉酮核心和高选择性溴化。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Synthetic Communications 化学-有机化学

CiteScore

4.40

自引率

4.80%

发文量

156

审稿时长

4.3 months

期刊介绍： Synthetic Communications presents communications describing new methods, reagents, and other synthetic work pertaining to organic chemistry with sufficient experimental detail to permit reported reactions to be repeated by a chemist reasonably skilled in the art. In addition, the Journal features short, focused review articles discussing topics within its remit of synthetic organic chemistry.