Substance Use & Misuse最新文献_第2页

When Feeling Good Isn't Enough: Hedonic Well-Being Hinders the Use of Coping Strategies Following Detoxification for Alcohol Use Disorder. 当感觉良好还不够时：快乐的幸福感阻碍了酒精使用障碍解毒后应对策略的使用。

IF 1.7 4区医学

Substance Use & Misuse Pub Date : 2026-09-26 DOI: 10.1080/10826084.2026.2735455

Enrique Rubio-Escobar, Laura Esteban-Rodríguez, Víctor Armada, Gonzalo Hervás, Covadonga Chaves, Miguel Ángel Pérez Nieto

{"title":"When Feeling Good Isn't Enough: Hedonic Well-Being Hinders the Use of Coping Strategies Following Detoxification for Alcohol Use Disorder.","authors":"Enrique Rubio-Escobar, Laura Esteban-Rodríguez, Víctor Armada, Gonzalo Hervás, Covadonga Chaves, Miguel Ángel Pérez Nieto","doi":"10.1080/10826084.2026.2735455","DOIUrl":"https://doi.org/10.1080/10826084.2026.2735455","url":null,"abstract":"Introduction: Hedonic well-being has been conceptualized as a protective factor in recovery from substance use disorders. However, its specific role in the early stages of abstinence remains unclear. The present study examined the relationship between emotional well-being and the use of coping strategies in response to alcohol consumption in patients with alcohol use disorder (AUD) following detoxification. Methodology: A cross-sectional observational design was employed with a sample of 92 patients in treatment (between 1 and 3 months of abstinence). Coping strategies were assessed using the Coping Behaviors Inventory (CBI), and hedonic well-being was measured using scales for positive and negative affect (PANAS), quality of life (WHOQOL-BREF), enjoyment orientation (EOS), happiness (PHI), and cognitive responses to positive affect (RPA). Descriptive analyses, Pearson correlations, and multiple linear regression were performed. Results: Participants showed inverse associations between well-being and the use of coping strategies. In the final regression model, PANAS Positive, RPA Self-Focus, and age emerged as significant inverse predictors of the total CBI score, explaining 17.4% of its variance (adjusted R2 = 0.146). These relationships were particularly evident in strategies such as positive thinking and distraction. Conclusions: The results suggest that, following detoxification from AUD, hedonic well-being is not necessarily associated with a greater use of coping strategies. On the contrary, high levels of positive affect may be linked to a lower perception of risk and reduced engagement in preventive behaviors. These findings challenge the hypothesis that well-being is exclusively a protective factor and highlight the need to integrate its promotion with the maintenance of vulnerability awareness following detoxification.","PeriodicalId":22088,"journal":{"name":"Substance Use & Misuse","volume":" ","pages":"1-10"},"PeriodicalIF":1.7,"publicationDate":"2026-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149064334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Childhood Maltreatment and Alcohol Use Among College-Enrolled Women: The Roles of Distress Tolerance and Negative Urgency. 女大学生的童年虐待与酒精使用：痛苦耐受性和消极紧迫性的作用

IF 1.7 4区医学

Substance Use & Misuse Pub Date : 2026-09-25 DOI: 10.1080/10826084.2026.2734265

Darya Vitus, Benjamin N Montemayor, Anka A Vujanovic

{"title":"Childhood Maltreatment and Alcohol Use Among College-Enrolled Women: The Roles of Distress Tolerance and Negative Urgency.","authors":"Darya Vitus, Benjamin N Montemayor, Anka A Vujanovic","doi":"10.1080/10826084.2026.2734265","DOIUrl":"https://doi.org/10.1080/10826084.2026.2734265","url":null,"abstract":"Background: Gender disparities in adverse alcohol-related consequences are well established, with women experiencing greater adverse health consequences than men even at lower levels of alcohol consumption. Childhood maltreatment has been implicated in these disparities, with maltreatment-exposed women demonstrating elevated risk for heavy drinking and alcohol-related problems in adulthood. Distress tolerance and negative urgency have been proposed as mechanisms linking maltreatment to adverse alcohol outcomes; however, research examining these mechanisms specifically among women remains limited.Methods: This study (N = 889 female university students; Mage = 22.35, SDage = 4.79) examined distress tolerance as a mediator and negative urgency as a moderator in the relationship between childhood maltreatment severity and three alcohol-related outcomes: consumption, consequences, and cumulative risk.Results: Greater childhood maltreatment severity was associated with lower distress tolerance and higher alcohol-related risk and consequences. Distress tolerance did not mediate the association between maltreatment severity and alcohol outcomes. However, alternative models indicated that maltreatment severity mediated the association between distress tolerance and alcohol-related consequences, and this indirect effect was consistent across levels of negative urgency.Conclusions: Findings highlight the importance of assessing childhood maltreatment histories to identify women at elevated alcohol-related risk and advance gender-informed prevention and intervention efforts.","PeriodicalId":22088,"journal":{"name":"Substance Use & Misuse","volume":" ","pages":"1-13"},"PeriodicalIF":1.7,"publicationDate":"2026-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149040548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical Characteristics and Treatment Outcomes Among Patients with Fentanyl-Positive Urine Drug Screening in Inpatient Detoxification and Rehabilitation. 芬太尼尿检阳性住院戒毒康复患者的临床特点及治疗效果

IF 1.7 4区医学

Substance Use & Misuse Pub Date : 2026-09-25 DOI: 10.1080/10826084.2026.2735454

Sean T Lynch, Kathryn Stevens, William Fletes, Kelly McManus, Edwin Salsitz, Lisa J Cohen, Carisa M Kymissis

{"title":"Clinical Characteristics and Treatment Outcomes Among Patients with Fentanyl-Positive Urine Drug Screening in Inpatient Detoxification and Rehabilitation.","authors":"Sean T Lynch, Kathryn Stevens, William Fletes, Kelly McManus, Edwin Salsitz, Lisa J Cohen, Carisa M Kymissis","doi":"10.1080/10826084.2026.2735454","DOIUrl":"10.1080/10826084.2026.2735454","url":null,"abstract":"Background: Fentanyl is a major driver of overdose mortality in the United States, yet less is known about patients with fentanyl-positive urine drug screening (UDS) entering inpatient addiction treatment. Methods: This retrospective cohort study included patients admitted to an inpatient detoxification and rehabilitation unit at an academic behavioral health center from January 1 to March 31, 2024. Patients were classified according to fentanyl-positive or fentanyl-negative admission UDS; confirmatory testing was not performed. Sociodemographic, clinical, and treatment variables and 1-year readmission were compared using chi-square and t-tests. Kaplan-Meier analysis assessed time to readmission, and multivariable logistic regression identified factors associated with fentanyl-positive UDS. Results: Among 196 patients, 75 (38.3%) had fentanyl-positive UDS. These patients had higher rates of incarceration and polysubstance use. In multivariable analyses, primary opioid use (OR 12.85, 95% CI 3.47-47.65), stimulant use (OR 3.35, 95% CI 1.03-10.91), and incarceration history (OR 4.14, 95% CI 1.43-11.94) were independently associated with fentanyl-positive UDS. Detoxification completion, rehabilitation completion, length of stay, and 1-year readmission (33.7%) did not differ between groups. Conclusions: Fentanyl-positive UDS was common and associated with greater polysubstance use and incarceration history, but not poorer short-term outcomes. Screening-based classification without confirmatory testing and uncertainty regarding the clinical primacy of fentanyl limit conclusions regarding fentanyl-specific effects.","PeriodicalId":22088,"journal":{"name":"Substance Use & Misuse","volume":" ","pages":"1-11"},"PeriodicalIF":1.7,"publicationDate":"2026-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149064360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring Gender-Based Differences in Hazardous Alcohol Use Outcomes Among Drug Treatment Court Participants: The Role of Health and Well-Being Across Multiple Dimensions. 在药物治疗法庭参与者中探索危险酒精使用结果的性别差异：健康和福祉在多个维度中的作用。

IF 1.7 4区医学

Substance Use & Misuse Pub Date : 2026-09-22 DOI: 10.1080/10826084.2026.2734267

Malaiikha N McCormick-Cisse, D Lynn Homish, Alison M Haney, Jessica A Kulak, Linda S Kahn, Gregory G Homish

{"title":"Exploring Gender-Based Differences in Hazardous Alcohol Use Outcomes Among Drug Treatment Court Participants: The Role of Health and Well-Being Across Multiple Dimensions.","authors":"Malaiikha N McCormick-Cisse, D Lynn Homish, Alison M Haney, Jessica A Kulak, Linda S Kahn, Gregory G Homish","doi":"10.1080/10826084.2026.2734267","DOIUrl":"https://doi.org/10.1080/10826084.2026.2734267","url":null,"abstract":"Background: In general populations, the prevalence of alcohol use has increased among women and remained constant among men. Little is known about the alcohol use patterns of women in drug treatment court (DTC) or how these behaviors are influenced by quality of life (QoL). This study examined whether multiple dimensions of QoL longitudinally predict subsequent hazardous alcohol use (AUDIT ≥ 8) outcomes and whether these associations varied by gender.Methods: Data are from five waves (baseline to 12 months) of the Health Evaluation on the Results of Opioid Intervention Court (HEROIC). Participants' (N = 165) alcohol use (AUDIT) and QoL (RAND SF-36) were assessed every three months. Generalized estimating equations (GEEs) were used to examine associations between lagged QoL domains and subsequent hazardous alcohol use. Adjusted models examined gender and controlled for age, education, race/ethnicity, and treatment court setting.Results: Hazardous alcohol use decreased over time across the sample. Lagged emotional well-being predicted hazardous alcohol use in full models, such that more emotional well-being was related to a lower likelihood of hazardous alcohol use. General health and social functioning were not longitudinally related to hazardous alcohol use. Previous associations did not differ by gender.Conclusion: In full models, emotional well-being predicted hazardous alcohol use, and there was a null effect of gender. General health and social functioning did not predict hazardous alcohol use, nor was gender significant in predicting problematic alcohol use. Emotional well-being may be a key QoL target for decreasing hazardous alcohol use among all DTC participants.","PeriodicalId":22088,"journal":{"name":"Substance Use & Misuse","volume":" ","pages":"1-8"},"PeriodicalIF":1.7,"publicationDate":"2026-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149025897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring the Dimensions of Substance Use Recovery: A Qualitative Study Among Adults in Illinois. 探索物质使用恢复的维度：伊利诺伊州成年人的定性研究。

IF 1.7 4区医学

Substance Use & Misuse Pub Date : 2026-09-22 DOI: 10.1080/10826084.2025.2568942

Jennifer M Evans, Douglas C Smith, Alex Lee, Flora Cohen, Crystal A Reinhart

{"title":"Exploring the Dimensions of Substance Use Recovery: A Qualitative Study Among Adults in Illinois.","authors":"Jennifer M Evans, Douglas C Smith, Alex Lee, Flora Cohen, Crystal A Reinhart","doi":"10.1080/10826084.2025.2568942","DOIUrl":"https://doi.org/10.1080/10826084.2025.2568942","url":null,"abstract":"Background: This qualitative study explores the subjective perspectives of adults who identify as being in recovery from substance use disorder (SUD), The central question was \"How do adults in recovery define recovery?\" While existing studies predominantly focus on individuals currently in treatment, this study broadens its scope to include a community sample.Methods and data analysis: This study employed a survey-based methodology, including participants in recovery from SUD (n = 147). Respondents were prompted to articulate their understanding of recovery in 2-3 sentences. The study adopted a pragmatic qualitative approach, using inductive and deductive thematic analysis to extract and interpret patterns within the participants' responses. Inductive analysis was used to identify the primary themes and subthemes, and deductive analysis was used to apply those themes to the biopsychosocial model of addiction.Findings: Analyses revealed several recurring themes, including substance use reduction, effort or trying, self-improvement, engagement in recovery activities, and the notion of a lifelong change. This research highlights the need for a nuanced understanding of recovery extending beyond traditional treatment contexts.Conclusion: Identified themes provided guidance for enhancing recovery-oriented systems of care, with emphases on more inclusive and practical approaches to supporting recovery. As the concept of recovery continually evolves, future research is recommended to explore and refine these key components.","PeriodicalId":22088,"journal":{"name":"Substance Use & Misuse","volume":" ","pages":"1-10"},"PeriodicalIF":1.7,"publicationDate":"2026-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149017459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Relative Preference of Cannabis, Alcohol, and Nicotine Products Among U.S. Adolescents and Young Adults Who Are Using or Susceptible to Cannabis Use: Insights from a Best-Worst Scaling Study. 在使用大麻或易受大麻影响的美国青少年和年轻人中，大麻、酒精和尼古丁产品的相对偏好：来自最佳-最差尺度研究的见解

IF 1.7 4区医学

Substance Use & Misuse Pub Date : 2026-09-22 DOI: 10.1080/10826084.2026.2731166

Lei Xu, Shiqi Zhang, Mohamed Elsaid, Ce Shang

{"title":"Relative Preference of Cannabis, Alcohol, and Nicotine Products Among U.S. Adolescents and Young Adults Who Are Using or Susceptible to Cannabis Use: Insights from a Best-Worst Scaling Study.","authors":"Lei Xu, Shiqi Zhang, Mohamed Elsaid, Ce Shang","doi":"10.1080/10826084.2026.2731166","DOIUrl":"10.1080/10826084.2026.2731166","url":null,"abstract":"Background: The prevalence of multiple substance use is high among U.S. adolescents and young adults (AYAs), particularly as market shifts with alcohol and cannabis being the most prevalent substances and nicotine vaping displacing cigarette smoking among this population. However, it remains unclear how AYAs evaluate diverse products in terms of preference, addictiveness, and risk.Methods: We analyzed data from a nationally representative sample of 1,010 U.S. AYAs (aged 15-21) in June 2024 who had used cannabis in the past 30 days or were susceptible to use. Best-worst scaling (BWS) was used to elicit relative preferences across alcohol, tobacco, and cannabis forms. Product-level indices for liking, addictiveness, and risk were analyzed using fractional logistic regression.Results: Cannabis edibles, alcohol, and cannabis flower ranked highest in liking, while tobacco products-especially cigarettes-were less preferred. E-cigarettes and oral nicotine pouches were more favored than cigarettes but remained less liked than cannabis products. Among cannabis forms, cartridges were perceived as both the most addictive and risky, whereas topicals were viewed as least harmful. Regression results showed cannabis oil and most tobacco products were less liked than flowers, while topicals were perceived as less addictive and risky than flowers.Conclusions: AYAs favor cannabis edibles and alcohol while disfavoring traditional tobacco products. Perceptions of risk and addictiveness align with product delivery modes, particularly for high-THC vaping products. These findings suggest both substitution (e.g., away from cigarettes) and complementarity (e.g., cannabis and alcohol), underscoring the need for integrated, multi-product regulatory strategies targeting evolving substance markets.","PeriodicalId":22088,"journal":{"name":"Substance Use & Misuse","volume":" ","pages":"1-11"},"PeriodicalIF":1.7,"publicationDate":"2026-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13673744/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149025946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Electronic Nicotine Delivery Systems Use Among Students in the Eastern Mediterranean Region: A Systematic Review and Meta-Analysis of 60 Studies on Prevalence and Socioeconomic Determinants. 东地中海地区学生使用电子尼古丁输送系统：60项关于流行和社会经济决定因素的研究的系统回顾和荟萃分析。

IF 1.7 4区医学

Substance Use & Misuse Pub Date : 2026-09-21 DOI: 10.1080/10826084.2026.2734485

Mozhgan Seif, Sara Moghaddam, Hossein Kargar Jahromi, Mohammad Sadegh Moradi Sarcheshmeh, Hamed Delam

{"title":"Electronic Nicotine Delivery Systems Use Among Students in the Eastern Mediterranean Region: A Systematic Review and Meta-Analysis of 60 Studies on Prevalence and Socioeconomic Determinants.","authors":"Mozhgan Seif, Sara Moghaddam, Hossein Kargar Jahromi, Mohammad Sadegh Moradi Sarcheshmeh, Hamed Delam","doi":"10.1080/10826084.2026.2734485","DOIUrl":"10.1080/10826084.2026.2734485","url":null,"abstract":"Background: The rapid global increase in Electronic Nicotine Delivery Systems (ENDS) use among youth is a pressing public health concern. However, comprehensive data for the Eastern Mediterranean Region (EMRO) remains sparse. This study aimed to conduct a systematic review and meta-analysis to determine the pooled prevalence of ENDS use among student populations in EMRO countries.Methods: Following PRISMA guidelines, a systematic search was conducted across PubMed, Scopus, Web of Science, and Embase for studies published up to August 2025. Observational studies reporting the prevalence of current or lifetime ENDS use in EMRO countries were included. A random-effects meta-analysis model was employed to calculate pooled prevalence estimates. Meta-regression analysis was performed to assess the association between the Human Development Index (HDI) and ENDS prevalence.Results: Sixty studies (n = 92,636) were included. 81.7% of the included studies were rated as high quality on the Newcastle-Ottawa Scale. The overall pooled current prevalence of ENDS use was 21% (95% CI: 17.0-24.0), while the lifetime prevalence was 24% (95% CI: 20-29). A significant sex disparity was observed, with current use higher in males (28%) than females (14%). Meta-regression revealed a statistically significant inverse relationship between a country's HDI and both current (slope: -1.81, p < 0.01) and lifetime (slope: -3.11, p < 0.001) ENDS prevalence.Conclusion: ENDS use is highly prevalent among students in the EMRO region, particularly among males. The strong negative correlation with HDI suggests higher use is associated with lower socioeconomic development. These findings highlight an urgent need for targeted regulatory and public health interventions tailored to the region's specific socioeconomic context.","PeriodicalId":22088,"journal":{"name":"Substance Use & Misuse","volume":" ","pages":"1-23"},"PeriodicalIF":1.7,"publicationDate":"2026-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149012743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Predictors of Naloxone Carriage Among People Who Use Opioids in Maine. 缅因州阿片类药物使用者中纳洛酮携带的预测因素

IF 1.7 4区医学

Substance Use & Misuse Pub Date : 2026-09-20 DOI: 10.1080/10826084.2026.2729567

Sam A Slavin-Hall, Robert W Glover

{"title":"Predictors of Naloxone Carriage Among People Who Use Opioids in Maine.","authors":"Sam A Slavin-Hall, Robert W Glover","doi":"10.1080/10826084.2026.2729567","DOIUrl":"https://doi.org/10.1080/10826084.2026.2729567","url":null,"abstract":"Background: Despite expanded naloxone distribution efforts, many people who use opioids (PWUO) do not carry naloxone. Limited research examines how knowledge of Good Samaritan Laws (GSLs), trust in law enforcement to uphold these protections, and opioid use patterns impact naloxone carriage, particularly in rural contexts. This study addresses these gaps by assessing predictors of carriage in a rural U.S. setting.Methods: This cross-sectional study analyzes survey data from a non-probability sample of 153 PWUO in Maine recruited through community outreach. Ordinary least squares regression models identify predictors of naloxone carriage during opioid use (Model 1) and in general (Model 2).Results: Across both models, more frequent opioid use and a history of overdose are associated with greater naloxone carriage. In Model 1, lower trust in law enforcement to uphold GSL protections is suggestively associated with higher carriage. In Model 2, higher perceived overdose risk and non-White race are associated with lower naloxone carriage.Conclusions: Findings highlight variation in naloxone carriage across behavioral, perceptual, and structural factors. Expanding naloxone outreach and education, normalizing carriage, strengthening post-overdose interventions, and addressing structural barriers may improve carriage among high-risk populations, particularly in rural settings.","PeriodicalId":22088,"journal":{"name":"Substance Use & Misuse","volume":" ","pages":"1-11"},"PeriodicalIF":1.7,"publicationDate":"2026-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149012664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Amanita Muscaria Mushrooms: An Online Retail Assessment of Branded Retailers, 2025. Amanita Muscaria蘑菇：品牌零售商在线零售评估，2025。

IF 1.7 4区医学

Substance Use & Misuse Pub Date : 2026-09-19 DOI: 10.1080/10826084.2026.2734264

Cassidy R LoParco, Kayla K Tillett, Matthew E Rossheim, Sarah A Okey, Carla J Berg

{"title":"Amanita Muscaria Mushrooms: An Online Retail Assessment of Branded Retailers, 2025.","authors":"Cassidy R LoParco, Kayla K Tillett, Matthew E Rossheim, Sarah A Okey, Carla J Berg","doi":"10.1080/10826084.2026.2734264","DOIUrl":"https://doi.org/10.1080/10826084.2026.2734264","url":null,"abstract":"Objective: Amanita muscaria mushrooms, known for their hallucinogenic effects, have grown in popularity and availability. However, use can cause delirium, coma, and death. Moreover, the US Food and Drug Administration (FDA) has stated that Amanita muscaria, its extracts, and certain constituents (muscimol, ibotenic acid, and muscarine) are unapproved additives that do not meet the Generally Recognized as Safe standard, meaning that edible products containing them are adulterated under federal law (illegal to market and sell) and are subject to enforcement.Methods: In April 2025, we examined the online retail of Amanita muscaria products among the 13 most-trafficked websites identified, including factors known to highly influence access, use, and related risk.Results: Among these 13 retailers, 8 (61.5%) asked about age to enter the website, 8 (61.5%) had state-based shipping restrictions, and 9 (69.2%) offered price discounts. Some A.muscaria products also contained THCP and delta-9 THC. Websites sold A.muscaria gummies (n = 12, 92.3%) and chocolate bars (n = 5, 38.5%). The average price of the least expensive A.muscaria product was $29.74 for gummies (range: $11.99-$36.99) and $36.59 (range: $25.00-$50.00) for chocolate bars. Among those that specified A.muscaria amount, the average was 4,182mg (2,000mg-8,000mg) for gummies (n = 11) and 6,500mg (5,000mg-8,000mg) for chocolate bars (n = 2). Eleven websites contained marketing-related product descriptions, including general advertising (n = 11 [100%]; e.g., potential effects), dosing instructions (n = 10, 90.9%), and safety claims, recommendations, and warnings (n = 11 [100%]; e.g., mentioning lab testing, potential consequences).Discussion: Study findings help characterize a little-known market with considerable health implications.","PeriodicalId":22088,"journal":{"name":"Substance Use & Misuse","volume":" ","pages":"1-7"},"PeriodicalIF":1.7,"publicationDate":"2026-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149008541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Pathways Project: Exploring Substance Use Trajectories and Opioid-Related Outcomes in Adults Seeking Support for Substance Use Health. 途径项目：探索成人寻求物质使用健康支持的物质使用轨迹和阿片类药物相关结果。

IF 1.7 4区医学

Substance Use & Misuse Pub Date : 2026-09-18 DOI: 10.1080/10826084.2026.2711400

Lena Catherine Quilty, Oghenetega Otevwe, Corina Ziara Dubon Picco, Marcos Sanches, Farihah Ali, Narges Beyraghi, Nikki Bozinoff, Jürgen Rehm, Cayley Russell, Samantha Wells, Leslie Buckley

{"title":"The Pathways Project: Exploring Substance Use Trajectories and Opioid-Related Outcomes in Adults Seeking Support for Substance Use Health.","authors":"Lena Catherine Quilty, Oghenetega Otevwe, Corina Ziara Dubon Picco, Marcos Sanches, Farihah Ali, Narges Beyraghi, Nikki Bozinoff, Jürgen Rehm, Cayley Russell, Samantha Wells, Leslie Buckley","doi":"10.1080/10826084.2026.2711400","DOIUrl":"https://doi.org/10.1080/10826084.2026.2711400","url":null,"abstract":"Objective: Opioid-related harms in Canada have escalated over the past decade, yet little is known about current substance use pathways among adults seeking support for substance use. Most clinical measures focus on current symptoms rather than sequencing or timing of substance use initiation. This study addresses this gap by examining patterns of substance initiations, timing, and progression in a large clinical sample seeking substance use treatment at the Center for Addiction and Mental Health (CAMH). Method: Participants (N = 200) completed a survey of substance use over the lifespan alongside measures of opioid use disorder (OUD) symptoms, substance-related consequences, and treatment history. Analyses included Cox proportional hazard models predicting opioid initiation, and latent class analysis (LCA) to identify substance initiation profiles. Results: Alcohol (90.5%), cannabis (71.5%), and tobacco (58.5%) were the most commonly used and earliest initiated substances. Lifetime opioid use was reported by 63.5% of participants, with 40.5% endorsing ≥2 OUD symptoms. Individuals with OUD symptoms initiated alcohol, cannabis, and tobacco at earlier ages (p < 0.05). Initiation of cannabis and tobacco was associated with earlier opioid initiation, whereas alcohol with later opioid initiation. Four substance use classes emerged, characterized by primarily alcohol use (alcohol only), common substance use (prevalent substances), broad polysubstance use (multiuse), and opioid involvement (opioid). Conclusions: Adult substance use pathways among individuals seeking treatment are diverse. Early initiation of cannabis and tobacco were associated with opioid involvement. Pathways-based assessment and early intervention may strengthen prevention, harm reduction, and treatment strategies.","PeriodicalId":22088,"journal":{"name":"Substance Use & Misuse","volume":" ","pages":"1-10"},"PeriodicalIF":1.7,"publicationDate":"2026-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149002543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0