Sultan Qaboos University Medical Journal最新文献

{"title":"Adalimumab Therapy for Crohn's Disease and Axial Spondyloarthritis in Latent Tuberculosis: <i>A bibliometric-systematic literature review</i>.","authors":"Nyimas Maida Shofa, Nurike Setiyari Mudjari, Rusdiyana Ekawati, Arianti Arianti, Annisa Zahra Mufida, Budi Widodo, Titong Sugihartono","doi":"10.18295/2075-0528.2971","DOIUrl":"10.18295/2075-0528.2971","url":null,"abstract":"<p><p>The management of Crohn's disease (CD) using anti-tumour necrosis factor therapy in tuberculosis (TB)-endemic regions poses major clinical challenges due to the risk of latent TB infection reactivation. This bibliometric-systematic literature review synthesised evidence from 17 peer-reviewed studies (2020-2025) evaluating adalimumab administered with concurrent prophylactic antitubercular therapy. Thematic synthesis and bibliometric mapping using VOSviewer demonstrated that adalimumab achieved 60-85% clinical remission in moderate-to-severe CD and axial spondyloarthritis while enhancing mucosal healing. However, 1-3% of patients developed active TB despite appropriate screening and isoniazid prophylaxis, revealing false-negative diagnostics and partial chemoprophylaxis protection. These findings highlight the need for region-specific frameworks integrating multimodal screening, targeted prophylaxis and ongoing clinical surveillance. Adalimumab remains a cornerstone biologic in TB-endemic settings, but its safe use requires adaptive, context-driven protocols emphasising vigilant risk mitigation.</p>","PeriodicalId":22083,"journal":{"name":"Sultan Qaboos University Medical Journal","volume":"26 1","pages":"171-183"},"PeriodicalIF":0.0,"publicationDate":"2026-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12969460/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147434850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Applications of Chatbots in Improving Patient Care Outcomes: <i>A scoping review</i>.","authors":"Mohammadhiwa Abdekhoda, Afsaneh Dehnad","doi":"10.18295/2075-0528.2970","DOIUrl":"10.18295/2075-0528.2970","url":null,"abstract":"<p><p>This review explored the application of chatbots in healthcare, focusing on patient monitoring, personalised care and medical services. It examined the potential of chatbots to improve patient outcomes through artificial intelligence-driven technologies, addressing challenges such as data security and system integration. This scoping review, conducted from January to March 2025, adhered to the PRISMA-ScR guidelines. A thorough literature search was performed across Web of Science, Scopus and PubMed, using keywords such as \"patient care\", \"outcome\", and \"chatbot*\". After screening for relevance and applying inclusion criteria, a total of 70 articles were analysed, focusing on chatbots' roles in improving patient care outcomes, data management and communication. Data charting was conducted by using a data extraction form to capture study characteristics, chatbot applications, outcomes and reported challenges. This study highlighted the surge in chatbot applications in healthcare from 2018 to 2024, focusing on 7 key themes: (1) increasing access to healthcare, (2) patient education and awareness (3) supporting clinical decision-making, (4) improving patient-healthcare professional communication, (5) chronic disease and symptom management, (6) telehealth and remote monitoring and (7) administrative support and workflow optimisation. Chatbots demonstrate significant potential to enhance patient care outcomes by improving access, communication, education and chronic disease management. Despite growing adoption of chatbots, challenges related to data security and system integration remain. Future research should focus on standardised evaluation frameworks and real-world clinical effectiveness.</p>","PeriodicalId":22083,"journal":{"name":"Sultan Qaboos University Medical Journal","volume":"26 1","pages":"163-172"},"PeriodicalIF":0.0,"publicationDate":"2026-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12969406/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147434966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Managing Acute Myocardial Infarction in Remote Oman: <i>Real-world data from Al Wusta Governorate</i>.","authors":"Thuraiya Malik Abdullah Al Harthi, Ibrahim Al Mahrouqi, Amin Elbanna, Karema Hamed, Mohammed Abushilla, Venkatesh Kumar, Maryam Al Nabhani, Hasina Al Harthi, Abdulmunim Al Farsi, Adil Al Mahrouqi","doi":"10.18295/2075-0528.2969","DOIUrl":"10.18295/2075-0528.2969","url":null,"abstract":"<p><strong>Objectives: </strong>Acute ST-segment elevation myocardial infarction (STEMI) is a time-sensitive cardiac emergency requiring prompt reperfusion therapy. Management and outcomes in remote areas are underexplored. This study explored the STEMI reperfusion network in Al Wusta governorate in Oman and evaluated the effectiveness of pharmacological thrombolysis in general practitioner (GP)-led, resource-limited hospitals.</p><p><strong>Methods: </strong>This retrospective study reviewed administrative health registries and medical records of patients presenting with STEMI to hospitals in the Al Wusta governorate between June 2017 and December 2024. Response to thrombolysis was defined as 50% resolution of ST-segment on electrocardiogram. Outcomes post-thrombolysis were prespecified. Multivariate logistic regression was used to identify predictors of thrombolysis failure.</p><p><strong>Results: </strong>A total of 139 patients were included and received pharmacological thrombolysis, of whom 136 (97.8%) were male and the mean age was 47.8 ± 9.8 years. Thrombolysis failed in 13 patients (9.4%); all 3 deaths (2.2%) occurred in this subgroup, representing a mortality rate of over 20% among those with failed thrombolysis. Alcohol consumption and anterolateral myocardial infarction were strongly associated with failed thrombolysis, with odds ratios of 4,417.7 (95% confidence interval [CI]: 22.4-868,125.8) and 48.9 (95% CI: 2.0-1,156.8), respectively. The reperfusion network functioned effectively despite the absence of percutaneous coronary intervention centres and formal emergency medical services.</p><p><strong>Conclusion: </strong>While high rates of successful pharmacological reperfusion were achieved in GP-led hospitals, failed thrombolysis remains a significant concern. Targeted interventions at both patient and health system levels are necessary to improve outcomes. This study offers valuable insights for optimising STEMI care and guiding policy development in underserved regions.</p>","PeriodicalId":22083,"journal":{"name":"Sultan Qaboos University Medical Journal","volume":"26 1","pages":"152-162"},"PeriodicalIF":0.0,"publicationDate":"2026-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12969435/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147435706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Re: Genetic Screening of Genome-Wide Association Studies-Derived Risk Loci for Type 2 Diabetes Mellitus: <i>Confirmation in the North Indian population</i>.","authors":"Mostafa Saadat","doi":"10.18295/2075-0528.2968","DOIUrl":"10.18295/2075-0528.2968","url":null,"abstract":"","PeriodicalId":22083,"journal":{"name":"Sultan Qaboos University Medical Journal","volume":"26 1","pages":"151"},"PeriodicalIF":0.0,"publicationDate":"2026-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12973076/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147435656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genetic Analysis and Clinical Effect of <i>ACE2</i> Gene Variants (rs2285666 and rs4646188) on Coronary Syndrome in Dyslipidaemia Patients.","authors":"Shaimaa Y Abdulfattah, Sumaya Saady","doi":"10.18295/2075-0528.2967","DOIUrl":"10.18295/2075-0528.2967","url":null,"abstract":"<p><strong>Objectives: </strong>This study aimed to investigate the association of two intronic polymorphisms of the <i>ACE2</i> gene (rs2285666 and rs4646188) with coronary artery disease (CAD) in Iraqi patients with dyslipidaemia.</p><p><strong>Methods: </strong>This case-control study was conducted from March to September 2023 at the Iraqi Center of Heart Disease, Baghdad, Iraq, and included patients with CAD and dyslipidaemia. Genotyping was performed using TaqMan probes and real-time qPCR.</p><p><strong>Results: </strong>A total of 170 participants were included in this study. Demographic, echocardiographic, and lipid profile data were analysed, revealing significant differences in age, left ventricular ejection fraction %, LV systolic diameter, LV diastolic diameter and lipid parameters. The T-allele of rs2285666 was significantly associated with CAD risk in both females (odds ratio [OR] = 2.06, 95% confidence interval [CI]: 1.06-4; <i>P</i> = 0.032) and males (OR = 3, 95% CI: 0.96-9.39; <i>P</i> = 0.05). Similarly, the G-allele of rs4646188 showed a significant association in both sexes (OR = 2.03, 95% CI: 0.99-4.15; <i>P</i> = 0.05) and (OR = 2.71, 95% CI: 1.07-6.93; <i>P</i> = 0.38). The polymorphisms were also linked to dyslipidaemia, with rs2285666 (CT+TT in females; <i>P</i> <0.001) and rs4646188 (G-allele in males; <i>P</i> = 0.037) associated with elevated total cholesterol levels. reduced high-density lipoprotein levels were linked to rs2285666 (T-allele in males; <i>P</i> = 0.034) and rs4646188 (AG+GG; <i>P</i> <0.001). Increased low-density lipoprotein levels were associated with rs2285666 (CT+TT; <i>P</i> = 0.006 in females; T-allele; <i>P</i> = 0.018 in males) and rs4646188 (G-allele in males; <i>P</i> = 0.022). Elevated triglyceride levels were linked to rs2285666 (CT+TT; <i>P</i> = 0.01) and rs4646188 (AG+GG; <i>P</i> = 0.001) in females.</p><p><strong>Conclusion: </strong>The T-allele of rs2285666 and the G-allele of rs4646188 were identified as potential risk factors for CAD in both sexes, with their effects influenced by dyslipidaemia status.</p>","PeriodicalId":22083,"journal":{"name":"Sultan Qaboos University Medical Journal","volume":"26 1","pages":"139-150"},"PeriodicalIF":0.0,"publicationDate":"2026-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12969405/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147435594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations Between Overt and Subclinical Hypothyroidism in Pregnancy and Adverse Maternal and Neonatal Outcomes: <i>A cohort study</i>.","authors":"Rahma Al Kindi, Noof Al Ghammari, Amina Al Malki, Aida Al Ismaili, Hana Al Sumri","doi":"10.18295/2075-0528.2966","DOIUrl":"10.18295/2075-0528.2966","url":null,"abstract":"<p><strong>Objectives: </strong>This study aimed to determine associations between hypothyroidism during pregnancy and selected maternal and neonatal outcomes.</p><p><strong>Methods: </strong>A retrospective, cohort study was conducted between January 2018 and December 2020 at the two main tertiary hospitals in Muscat, Oman. The study included 408 Omani pregnant women aged 18-45 years. Participants were divided into two groups: those diagnosed with overt or subclinical hypothyroidism (n = 201; exposed group) and those with normal thyroid function (n = 207; unexposed group), matched for relevant variables. Data were collected from electronic medical records to assess maternal and neonatal outcomes.</p><p><strong>Results: </strong>Most exposed women (94.5%) had overt hypothyroidism. No significant differences were observed between the two groups in gestational diabetes mellitus, gestational hypertension, or pre-eclampsia (<i>P</i> >0.05). Women with hypothyroidism had a significantly higher risk of iron deficiency anaemia at delivery (relative risk: 2.22, 95% confidence interval: 1.68-2.94; <i>P</i> = 0.05).</p><p><strong>Conclusion: </strong>Hypothyroidism during pregnancy was not associated with an increased risk of most adverse maternal or neonatal outcomes in this cohort. This may be attributed to the effective management of hypothyroidism, as the majority of affected women were on thyroxine therapy, maintaining a clinically and biochemically euthyroid state throughout pregnancy.</p>","PeriodicalId":22083,"journal":{"name":"Sultan Qaboos University Medical Journal","volume":"26 1","pages":"129-138"},"PeriodicalIF":0.0,"publicationDate":"2026-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12969451/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147435028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Paying the Price for Beauty Abroad: <i>Khoula Hospital's experience with complications following aesthetic procedures performed overseas, 2013-2023</i>.","authors":"Khalifa Al Alawi, Areej Al-Mamari, Maysa Al-Maawali, Ashima Alkabi, Al-Batul Al-Mufargi, Juhaina Al Tobi, Hoor Al-Khanjari, Yasmine Al Balushi, Rawan Al Mandhari, Rafal Aljadder, Sultan Al Shaqsi","doi":"10.18295/2075-0528.2965","DOIUrl":"10.18295/2075-0528.2965","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to evaluate the types and outcomes of complications arising from aesthetic surgeries performed abroad and subsequently managed at Khoula Hospital, Muscat, Oman.</p><p><strong>Methods: </strong>This retrospective study included patients who presented with post-aesthetic surgical complications after undergoing procedures outside Oman from January 2013 to December 2023. Data were extracted from Khoula Hospital's electronic health records, focusing on demographics, procedures performed, types of complications and outcomes, including admissions and surgical interventions.</p><p><strong>Results: </strong>A total of 191 patients with 488 recorded encounters were included. The most common procedures done overseas were abdominoplasty (50.8%), lipectomy (29.3%) and breast surgeries (17.8%); Iran was the most frequent destination (60.7%). The predominant complications included wound infections with gapping (36.1%), seromas (20.4%), cellulitis (11.0%) and abscesses (5.8%). Severe cases required intensive care unit admission, reconstructive surgeries or prolonged length hospital stay. Nearly half of the admitted patients required surgical intervention with 20.0% necessitating critical care.</p><p><strong>Conclusion: </strong>Aesthetic tourism poses substantial risks, with infections and wound complications being the most common postoperative issue. These findings highlight the need for public education, improved regulation and stronger follow-up systems to minimise adverse outcomes and reduce the hidden burden on the local healthcare system.</p>","PeriodicalId":22083,"journal":{"name":"Sultan Qaboos University Medical Journal","volume":"26 1","pages":"121-128"},"PeriodicalIF":0.0,"publicationDate":"2026-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12969434/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147435697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fructosamine and HbA1c for Monitoring Diabetes in Pregnancy: <i>Complementary or competing?</i>","authors":"Yosra Htira, Chaima Jemai, Emna Fennira, Zohra Hadj Ali, Olfa Lajili, Imen Hedfi, Jihene Bettaieb, Faika Ben Mami","doi":"10.18295/2075-0528.2964","DOIUrl":"10.18295/2075-0528.2964","url":null,"abstract":"<p><strong>Objectives: </strong>This study aimed to perform a comparative evaluation of glycaemic control using fructosamine and glycated haemoglobin (HbA1c) and to investigate the correlations between the means of these biomarkers and mean glycaemia in pregnant women.</p><p><strong>Methods: </strong>This prospective longitudinal study was conducted from January to December 2020 and included pregnant women with pregestational diabetes, recruited at the National Institute of Nutrition of Tunis, Tunis, Tunisia, before 12 weeks of amenorrhoea and followed-up until delivery.</p><p><strong>Results: </strong>A total of 71 pregnant women were included in this study. Glycaemic values decreased over the course of pregnancy and patients achieved better adherence to target glucose ranges. This improvement was statistically significant for fructosamine (<i>P</i> = 0.03) but not for HbA1c. Significant correlations were identified among mean HbA1c (<i>P</i> <0.001), fructosamine (<i>P</i> <0.001) and corrected fructosamine levels (<i>P</i> <0.001). Trimester-specific analyses indicated that mean HbA1c was significantly correlated with fasting and mean blood glucose levels exclusively in the first trimester. Fructosamine levels exhibited significant positive correlations with fasting and mean blood glucose levels during the first trimester (r = 0.468 and r = 0.523, respectively; <i>P</i> <0.001) as well as with mean blood glucose levels in the second (r = 0.494; <i>P</i> <0.001) and third trimesters (r = 0.348; <i>P</i> = 0.03). Corrected fructosamine levels were significantly positively correlated with mean fasting and mean blood glucose levels in the first (<i>P</i> <0.001) and second trimesters (<i>P</i> <0.001) and with mean blood glucose levels in the third trimester (<i>P</i> = 0.01).</p><p><strong>Conclusion: </strong>These findings indicate that fructosamine and HbA1c serve complementary roles in monitoring glycaemic control during pregnancy among women with diabetes.</p>","PeriodicalId":22083,"journal":{"name":"Sultan Qaboos University Medical Journal","volume":"26 1","pages":"112-120"},"PeriodicalIF":0.0,"publicationDate":"2026-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12969469/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147435461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel <i>ANKRD11</i> Mutation in KBG Syndrome: <i>A diagnostic triad of hearing loss, radiological macrodontia and artificial intelligence-assisted facial phenotyping</i>.","authors":"Azzeddine Laaraje, Khadija Belcadi Abassi, Mouna Lemaamer, Abdelilah Radi, Amale Hassani, Rachid Abilkassem","doi":"10.18295/2075-0528.2963","DOIUrl":"10.18295/2075-0528.2963","url":null,"abstract":"<p><p>KBG syndrome is a rare autosomal dominant disorder characterised by developmental delay, characteristic facial features, macrodontia and skeletal anomalies, caused by mutations in the <i>ANKRD11</i> gene. We report a 5.5-year-old Moroccan boy who presented in 2022 to a tertiary military teaching hospital in Rabat, Morocco, with psychomotor delay, autistic traits, epilepsy, bilateral hearing loss with chronic otomastoiditis and radiologically-detected macrodontia before clinical eruption, in whom artificial intelligence-assisted facial phenotyping suggested the diagnosis, subsequently confirmed by identification of a novel nonsense mutation (c.1977C>G; p.Tyr659Ter). Multidisciplinary management including antiepileptic therapy, speech therapy and audiological follow-up resulted in satisfactory seizure control and developmental progress.</p>","PeriodicalId":22083,"journal":{"name":"Sultan Qaboos University Medical Journal","volume":"26 1","pages":"104-111"},"PeriodicalIF":0.0,"publicationDate":"2026-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12969402/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147435636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thoracic Aorta Calcification and Risk of All-Cause Mortality and Cardiovascular Outcomes: <i>A systematic review and meta-analysis</i>.","authors":"Yasir Salah Jumah Alam, Hussein Nafakhi, Alaa Salah Jumaah, Akeel Abed Yasseen, Zahraa Alaa Salah Alam, Ali Athir Abdulraheem","doi":"10.18295/2075-0528.2960","DOIUrl":"10.18295/2075-0528.2960","url":null,"abstract":"<p><p>This review aimed to assess thoracic aorta calcification (TAC) as a predictor of all-cause mortality, cardiovascular (CV) morbidity and mortality across various clinical settings using different imaging modalities. Medical databases were systematically searched up to mid-July 2025 for studies linking TAC with mortality and CV outcomes. A total of 43 studies involving 176,738 participants were included. TAC was associated with higher risks of all-cause mortality (hazard ratio [HR] = 1.614), CV mortality (HR = 2.130), coronary events (HR = 1.423), major adverse cardiac events (HR = 2.011) and stroke (HR = 1.450. Computed tomography showed the strongest associations (all-cause mortality HR = 1.810; CV mortality HR = 2.641), followed by chest radiography and echocardiography. Mortality risk was elevated across all aortic segments, including descending aorta (HR = 1.414), aortic arch (HR = 1.362), ascending aorta (HR = 1.350) and aortic root (HR = 1.240). TAC is a strong predictor of all-cause mortality, coronary events, CV mortality and morbidity.</p>","PeriodicalId":22083,"journal":{"name":"Sultan Qaboos University Medical Journal","volume":"26 1","pages":"92-103"},"PeriodicalIF":0.0,"publicationDate":"2026-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12969457/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147435734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}