Sultan Qaboos University Medical Journal最新文献

{"title":"Autosomal Recessive Spastic Ataxia of Charlevoix-Saguenay with Early-Onset Epilepsy and Novel Clinical Features: <i>A rare entity from Morocco in the Middle East and North Africa region</i>.","authors":"Azzeddine Laaraje, Basma Alaoui, Abdelilah Radi, Amal Hasani, Aomar Agadr, Rachid Abilkassem","doi":"10.18295/2075-0528.2906","DOIUrl":"10.18295/2075-0528.2906","url":null,"abstract":"<p><p>We report a novel presentation of autosomal recessive spastic ataxia of Charlevoix-Saguenay (ARSACS) in a 9-year-old Moroccan male patient born to consanguineous parents, expanding the known clinical spectrum of the disease. The patient presented to a tertiary care hospital in Rabat, Morocco, in 2023. This case presents an unusual phenotype with early-onset epilepsy beginning at age 5, significantly broadening the known phenotypic spectrum of ARSACS. While initial neuroimaging was unremarkable, the patient exhibited classical retinal involvement with bilateral nerve fibre layer thickening. Genetic analysis revealed a previously unreported homozygous frameshift mutation in the <i>SACS</i> gene (c.12429delT), representing the first documented case in the Moroccan population. This observation extends both the understanding of ARSACS' clinical heterogeneity and its geographical distribution in North Africa. The patient responded favourably to antiepileptic treatment and physiotherapy which underscores the importance of early recognition and multidisciplinary management in atypical presentations. This case highlights the necessity of considering ARSACS in the differential diagnosis of early-onset ataxia with epilepsy, particularly in consanguineous populations.</p>","PeriodicalId":22083,"journal":{"name":"Sultan Qaboos University Medical Journal","volume":"25 1","pages":"756-761"},"PeriodicalIF":0.0,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12445317/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145114065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of Erectile Dysfunction and its Psychological Impact on Patients with Ischaemic Heart Disease in Oman.","authors":"Almunqith Al-Abri, Reema Al-Majrafi, Ahmed Al-Maskari, Qasim Al-Mamari, Sunil K Nadar","doi":"10.18295/2075-0528.2897","DOIUrl":"10.18295/2075-0528.2897","url":null,"abstract":"<p><strong>Objectives: </strong>This study aimed to assess the incidence of erectile dysfunction (ED) in male patients with ischaemic heart disease (IHD) and to assess the psychological impact on these patients.</p><p><strong>Methods: </strong>This questionnaire-based pilot study was conducted at the outpatient Cardiology Department of the Sultan Qaboos University Hospital, Muscat, Oman between January and December 2023. ED was assessed using the 5-item International Index of Erectile Function and the psychological state was assessed using the Depression Anxiety Stress Scale.</p><p><strong>Results: </strong>A total of 100 patients were included in this study (mean age = 59.5 ± 10.4 years); 62 patients self-reported ED and 69 had some form of ED based on the questionnaire. Moderate to severe ED was found in 30 patients; these patients were older (66.7 ± 10.4 versus 56.4 ± 8.8; <i>P</i> <0.001), more likely to have hypertension (93.3% versus 65.7%; <i>P</i> = 0.004) and hyperlipidaemia (93.3% versus 70%; <i>P</i> = 0.01) and less likely to have undergone PCI (70% versus 88.6%; <i>P</i> = 0.02). There was no effect of drug therapy or other co-morbidities. By binary logistic regression, age was the only predictive factor for ED (odds ratio = 1.12, 95% confidence interval: 1.04-1.22; <i>P</i> = 0.003). Additionally, 32%, 14% and 13% had severe or very severe anxiety, stress and depression, respectively. The ED score corelated negatively and significantly with the anxiety score (r = -0.485; <i>P</i> <0.001), the stress score (r = -0.36; <i>P</i> <0.001) and depression score (r = -0.38; <i>P</i> <0.001).</p><p><strong>Conclusion: </strong>This study found that ED is common in patients with IHD with significant psychological effects. Physicians should be aware of this while treating patients due to the effect on quality of life.</p>","PeriodicalId":22083,"journal":{"name":"Sultan Qaboos University Medical Journal","volume":"25 1","pages":"784-791"},"PeriodicalIF":0.0,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12445319/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145114097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anthracycline-Induced Cardiomyopathy in Breast Cancer Patients in Oman: <i>A retrospective study</i>.","authors":"Hussain A Al-Lawati, Khalid Al Baimani, Mohammed N Al Rawahi","doi":"10.18295/2075-0528.2891","DOIUrl":"https://doi.org/10.18295/2075-0528.2891","url":null,"abstract":"<p><strong>Objectives: </strong>Anthracyclines are widely used in the treatment of breast cancer. One of the known adverse effects of anthracyclines is anthracycline-induced cardiomyopathy. Studies done worldwide showed that the prevalence of chemotherapy-induced cardiomyopathy is approximately 9%. However, studies evaluating this complication prevalence, risk factors and cumulative dose are lacking in Oman. This study aimed to investigate the prevalence of anthracycline-induced cardiomyopathy among breast cancer patients in Oman.</p><p><strong>Methods: </strong>This retrospective study included all breast cancer patients who received anthracycline-based chemotherapy exclusively between September 2008 and December 2020 at Sultan Qaboos University Hospital in Muscat. Patients with partial treatment, coexisting heart failure and who did not receive anthracycline as part of the chemotherapy regimen were excluded. Chemotherapy-induced cardiomyopathy was defined as a drop of left ventricular ejection fraction >10% from the patient's baseline during or after receiving anthracycline-based chemotherapy.</p><p><strong>Results: </strong>A total of 385 patients were included in this study of which 39 (10.1%) developed cardiomyopathy after exposure to anthracyclines. The mean cumulative dose of doxorubicin among these patients was 239 mg/m² (epirubicin was converted to doxorubicin equivalent dose). Univariate analysis showed that the risk of anthracycline-induced cardiomyopathy was influenced by cardiovascular risk factors such as hypertension (33.3%), diabetes (25.6%), dyslipidaemia (20.5%) and previous cardiovascular medications use (10.3%). Trastuzumab exposure significantly correlated with an increased risk of developing cardiomyopathy (<i>P</i> < 0.001). However, multivariate analysis did not show any significant association.</p><p><strong>Conclusions: </strong>Anthracycline-induced cardiomyopathy was influenced by various cardiovascular risk factors as well as trastuzumab exposure. Further studies are recommended to investigate the prevention and management of anthracycline-induced cardiomyopathy.</p>","PeriodicalId":22083,"journal":{"name":"Sultan Qaboos University Medical Journal","volume":"25 1","pages":"839-846"},"PeriodicalIF":0.0,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12538945/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145347487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of Viruses in Odontogenic Cysts and Tumours: <i>A systematic review of literature and meta-analysis</i>.","authors":"Deepak Pandiar, Divya Gopinath, Pinky Pavithran, Reshma Poothakulath Krishnan, Jishnu Krishna Kumar, Sajesh K Veettil","doi":"10.18295/2075-0528.2847","DOIUrl":"10.18295/2075-0528.2847","url":null,"abstract":"<p><p>This review aimed to assess the prevalence of oncogenic and non-oncogenic viruses in odontogenic cysts and tumours. A comprehensive database search was performed for published articles regarding the presence of viruses in all odontogenic cysts and tumours, following guidelines without date constraints, and was registered with PROSPERO. After screening 164 articles, 24 studies were included for systematic evaluation. A meta-analysis was performed to determine the prevalence of human papillomavirus (HPV), revealing an overall pooled prevalence of HPV in ameloblastomas of 18.21% (95% confidence interval [CI]: 6.36-33.73) while the prevalence of HPV in odontogenic cysts was found to be 1.51% (95% CI: 0.00-9.46). The prevalence of Epstein-Barr virus in odontogenic tumours was 17.19% (95% CI: 4.62-34.49). Other viruses yielded varied results. Human carcinogenesis has previously been positively correlated with viruses; however, this systematic review's results indicate a very low prevalence in odontogenic pathoses and suggest a limited role in their aetiology.</p>","PeriodicalId":22083,"journal":{"name":"Sultan Qaboos University Medical Journal","volume":"25 1","pages":"370-381"},"PeriodicalIF":0.0,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12244234/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144609634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Symmetrical Peripheral Gangrene Associated with <i>Plasmodium Vivax</i> Malaria: <i>A case report with a brief review of literature</i>.","authors":"Atanu Chandra, Koustav A Shah, Debapratim Ganguly, Rupak Chatterjee, Sugata Dasgupta","doi":"10.18295/2075-0528.2842","DOIUrl":"10.18295/2075-0528.2842","url":null,"abstract":"<p><p>Symmetrical peripheral gangrene (SPG) is an exceptionally uncommon complication of malaria, predominantly linked with <i>Plasmodium falciparum</i> and mixed infections. We report a 41-year-old female who presented to a tertiary care centre of eastern India in 2022 with complaint of fever with chills and rigor for 4 days along with pain and acrocyanosis of distal portions of bilateral upper and lower limbs for last 2 days. Investigations revealed anaemia and neutrophilic leucocytosis with thrombocytopaenia. The peripheral smear revealed trophozoites of <i>P. vivax</i> and the malaria rapid diagnostic test confirmed the presence of <i>P. vivax</i> antigen. D-dimer and fibrin degradation product was elevated and prothrombin time and activated partial thromboplastin time were prolonged; arterial colour doppler of all 4 extremities were within normal limits. A diagnosis of <i>P. vivax</i> malaria was made complicated with disseminated intravascular coagulation leading to SPG.</p>","PeriodicalId":22083,"journal":{"name":"Sultan Qaboos University Medical Journal","volume":"25 1","pages":"336-340"},"PeriodicalIF":0.0,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12244251/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144609640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of Myofascial Release Compared to Manual Lymphatic Drainage in Reducing Post-Treatment Shoulder Pain and Stiffness Among Patients Who Underwent Breast Cancer Surgery and Adjuvant Radiotherapy: <i>Randomised controlled trial</i>.","authors":"Chellappa Vijayakumar, Ankit Jain, M Kalaranjani, Uday S Kumbhar, N Kumar, G S Sreenath","doi":"10.18295/2075-0528.2841","DOIUrl":"10.18295/2075-0528.2841","url":null,"abstract":"<p><strong>Objectives: </strong>This study aimed to adapt the myofascial release technique (MRT) in the form of massage, which will reduce pain and functional restriction of the shoulder joint compared to manual lymphatic drainage (MLD).</p><p><strong>Methods: </strong>This study was conducted in a tertiary care hospital in South India from September 2021 to September 2023. The study population included 98 patients older than 18 years who underwent surgery/adjuvant radiotherapy for breast cancer and developed complications. Patients with tendon/muscle injuries in neck/skin conditions, which made MRT difficult, were excluded. A trained physiotherapist delivered the interventions. Patient pain, range of movements at shoulder joint, shoulder dysfunction and quality of life were assessed at the time of the first (T0) and fourth session (T1) and after one month of the completion of treatment (T2).</p><p><strong>Results: </strong>Compared to the MLD group, the MRT group experienced significant reduction in pain (7-3 versus 6-4; <i>P</i> < 0.001), improvement in the shoulder range of movement (ROM) (1000-1320 to 1140-1400 with <i>P</i> < 0.001), reduction in shoulder dysfunction (52-40; <i>P</i> < 0.001 versus 45-40; <i>P</i> < 0.001) and improved QOL (22 and 83.5-26 and 92; <i>P</i> < 0.001 versus 24 and 79-24 and 83; <i>P</i> > 0.05).</p><p><strong>Conclusions: </strong>The use of MRT for a reduction in postoperative pain, reduction in shoulder dysfunction and improvement in shoulder ROM is effective and can be proposed to be employed in routine practice for better QOL postoperatively.</p>","PeriodicalId":22083,"journal":{"name":"Sultan Qaboos University Medical Journal","volume":"25 1","pages":"328-335"},"PeriodicalIF":0.0,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12244286/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144609575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incidence and Predictors of Permanent Pacemaker Implantation Following Transcatheter Aortic Valve Replacement: <i>Two-centre experience from Oman</i>.","authors":"Mohamed N Al Rawahi, Adil Al Kindi, Ahmed Al Yarubi, Ahmed Shams, Adil Al Riyami, Hatim Al Lawati, Ahmed El Said, Mohamed Al Riyami, Khalid Al Saidi, Ismail Al Abri, Najib Al Rawahi, Abdullah Al Ismaili, Fahad Al Kindi, Muhammad A Sadiq, Sunil K Nadar","doi":"10.18295/2075-0528.2831","DOIUrl":"10.18295/2075-0528.2831","url":null,"abstract":"<p><strong>Objectives: </strong>This study aims to evaluate the predictors and rate of permanent pacemaker (PPM) implantation among patients undergoing transcatheter aortic valve replacement (TAVR) at two institutions in Oman. TAVR has become the standard of care for patients with severe aortic stenosis at high risk for surgery. However, it is associated with a high PPM implantation rate.</p><p><strong>Methods: </strong>This was a retrospective study involving all patients undergoing TAVR at two leading cardiac centres in Oman over seven years, from May 2013 to September 2020. We included patients who survived the procedure to discharge and those who were followed-up for at least 1 year post-procedure.</p><p><strong>Results: </strong>A total of 153 patients (mean age = 74.2 ± 8.2 years; 82 males [53.6%]) were enrolled in the study. Of these, 15 patients (age = 74.3 ± 9.8 years, 46.6% male) required a permanent pacemaker within 1 year of follow-up, giving a pacemaker implantation rate of 9.8% following TAVR in the cohort. The factors that predicted the requirement of a pacemaker were pre-existing right bundle branch block (odds ratio [OR] = 10.9, 95% confidence interval [CI]: 3.31-36.33; <i>P</i> < 0.001); abnormal QRS axis (OR = 9.11, 95% CI: 2.77-29.91; <i>P</i> < 0.001); prolonged QRS duration (OR = 3.26, 95% CI: 1.06-9.92; <i>P</i> = 0.03); and any pre-existing conduction abnormality (OR = 1.18, 95% CI: 1.08-1.29; <i>P</i> = 0.01).</p><p><strong>Conclusions: </strong>The PPM implantation rates post-TAVR at two Omani institutions are comparable to those reported in the literature. Close rhythm surveillance is crucial, especially in patients with any of the predictors identified above, for the timely identification of susceptible patients who might require PPM implantation.</p>","PeriodicalId":22083,"journal":{"name":"Sultan Qaboos University Medical Journal","volume":"25 1","pages":"209-217"},"PeriodicalIF":0.0,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12240025/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144609619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevention of Post-Mastectomy Seroma in Breast Cancer Patients: <i>A comparative analysis of the effectiveness of fibrin glue versus quilting</i>.","authors":"Ibrahim A Umar, Bello M Bashir","doi":"10.18295/2075-0528.2850","DOIUrl":"10.18295/2075-0528.2850","url":null,"abstract":"<p><strong>Objectives: </strong>This study aimed to evaluate the effectiveness of fibrin glue versus quilting in preventing post-mastectomy seroma formation in breast cancer patients.</p><p><strong>Methods: </strong>This study was a prospective, randomised interventional trial conducted between July 2021 and June 2022 at Usmanu Danfodiyo University Teaching Hospital, Sokoto, Nigeria. It involving patients with breast cancer undergoing modified radical mastectomy. Patients were randomly assigned to Group A (fibrin glue) or Group B (quilting). The level of statistical significance was set at <i>P</i> < 0.05, corresponding to a 95% confidence interval.</p><p><strong>Results: </strong>A total of 42 patients were recruited for the study. The total volume of drainage for Group A was lower, and there was a statistically significant difference (<i>P</i> = 0.00) between the two groups. Similarly, the evaluation of the length of hospital stay and duration of drainage revealed a shorter period for Group A, with a statistically significant difference (<i>P</i> = 0.00) between the two groups. However, a comparison of seroma formation and post-mastectomy wound infection between the two groups revealed no statistically significant differences (<i>P</i> = 1.00).</p><p><strong>Conclusions: </strong>This study has demonstrated that there was no statistically significant difference in the effectiveness of fibrin glue compared to quilting in preventing post-mastectomy seroma in breast cancer patients. However, the fibrin glue group exhibited a lower volume of drainage, shorter duration of drainage and reduced length of hospital stay.</p>","PeriodicalId":22083,"journal":{"name":"Sultan Qaboos University Medical Journal","volume":"25 1","pages":"403-408"},"PeriodicalIF":0.0,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12244280/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144609636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Consanguinity: <i>The innocent culprit in autism severity</i>.","authors":"Watfa Al-Mamari, Ahmed B Idris, Najat Fadlallah, Saquib Jalees, Muna Al-Jabri, Halima Al-Shehhi, Maha Mohammed, Abeer Alsayegh","doi":"10.18295/squmj.10.2024.052","DOIUrl":"10.18295/squmj.10.2024.052","url":null,"abstract":"<p><strong>Objectives: </strong>This study aimed to investigate the relationship between consanguinity and the severity of autism spectrum disorder (ASD), a neurodevelopmental condition influenced by both genetic and environmental factors.</p><p><strong>Methods: </strong>This retrospective study, conducted at the Genetic & Developmental Medicine Clinic at Sultan Qaboos University Hospital (SQUH), Muscat, Oman, examined the records of 139 children aged 1.5 to 14 years who were diagnosed with ASD between June 2011 and May 2024. The study analysed the correlation between consanguinity, homozygosity and ASD severity.</p><p><strong>Results: </strong>Of the 139 cases evaluated, 74.1% were male, with an average age of diagnosis of 4.5 ± 2 years. Most ASD cases were classified at severity levels 2 (63.3%) and 3 (35.3%). Consanguinity was reported in 59% of the cases, with a mean homozygosity rate of 4.6%. No significant correlation was found between consanguinity or homozygosity rates and ASD severity.</p><p><strong>Conclusions: </strong>No significant association was found between consanguinity or homozygosity rates and ASD severity. Further research is necessary to explore the genetic mechanisms underlying ASD in consanguineous populations.</p>","PeriodicalId":22083,"journal":{"name":"Sultan Qaboos University Medical Journal","volume":"25 1","pages":"114-121"},"PeriodicalIF":0.0,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12255345/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144627054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mpox in the Gulf Cooperation Council Countries: <i>Addressing a new challenge to regional health security</i>.","authors":"Salah Al Awaidy, Jaffar A Al-Tawfiq, Faryal Khamis, Muna Al Maslamani, Jameela Al Salman, Sk Md Mamunur Rahman Malik","doi":"10.18295/2075-0528.1000","DOIUrl":"10.18295/2075-0528.1000","url":null,"abstract":"","PeriodicalId":22083,"journal":{"name":"Sultan Qaboos University Medical Journal","volume":"25 1","pages":"1-5"},"PeriodicalIF":0.0,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12255332/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144627057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}