Prevalence of Viruses in Odontogenic Cysts and Tumours: A systematic review of literature and meta-analysis.

Q3 Medicine

Sultan Qaboos University Medical Journal Pub Date : 2025-05-02 DOI:10.18295/2075-0528.2847

Deepak Pandiar, Divya Gopinath, Pinky Pavithran, Reshma Poothakulath Krishnan, Jishnu Krishna Kumar, Sajesh K Veettil

{"title":"Prevalence of Viruses in Odontogenic Cysts and Tumours: A systematic review of literature and meta-analysis.","authors":"Deepak Pandiar, Divya Gopinath, Pinky Pavithran, Reshma Poothakulath Krishnan, Jishnu Krishna Kumar, Sajesh K Veettil","doi":"10.18295/2075-0528.2847","DOIUrl":null,"url":null,"abstract":"This review aimed to assess the prevalence of oncogenic and non-oncogenic viruses in odontogenic cysts and tumours. A comprehensive database search was performed for published articles regarding the presence of viruses in all odontogenic cysts and tumours, following guidelines without date constraints, and was registered with PROSPERO. After screening 164 articles, 24 studies were included for systematic evaluation. A meta-analysis was performed to determine the prevalence of human papillomavirus (HPV), revealing an overall pooled prevalence of HPV in ameloblastomas of 18.21% (95% confidence interval [CI]: 6.36-33.73) while the prevalence of HPV in odontogenic cysts was found to be 1.51% (95% CI: 0.00-9.46). The prevalence of Epstein-Barr virus in odontogenic tumours was 17.19% (95% CI: 4.62-34.49). Other viruses yielded varied results. Human carcinogenesis has previously been positively correlated with viruses; however, this systematic review's results indicate a very low prevalence in odontogenic pathoses and suggest a limited role in their aetiology.","PeriodicalId":22083,"journal":{"name":"Sultan Qaboos University Medical Journal","volume":"25 1","pages":"370-381"},"PeriodicalIF":0.0000,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12244234/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Sultan Qaboos University Medical Journal","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.18295/2075-0528.2847","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"Medicine","Score":null,"Total":0}

引用次数: 0

Abstract

This review aimed to assess the prevalence of oncogenic and non-oncogenic viruses in odontogenic cysts and tumours. A comprehensive database search was performed for published articles regarding the presence of viruses in all odontogenic cysts and tumours, following guidelines without date constraints, and was registered with PROSPERO. After screening 164 articles, 24 studies were included for systematic evaluation. A meta-analysis was performed to determine the prevalence of human papillomavirus (HPV), revealing an overall pooled prevalence of HPV in ameloblastomas of 18.21% (95% confidence interval [CI]: 6.36-33.73) while the prevalence of HPV in odontogenic cysts was found to be 1.51% (95% CI: 0.00-9.46). The prevalence of Epstein-Barr virus in odontogenic tumours was 17.19% (95% CI: 4.62-34.49). Other viruses yielded varied results. Human carcinogenesis has previously been positively correlated with viruses; however, this systematic review's results indicate a very low prevalence in odontogenic pathoses and suggest a limited role in their aetiology.

Abstract Image

查看原文本刊更多论文

病毒在牙源性囊肿和肿瘤中的流行：文献和荟萃分析的系统回顾。

本综述旨在评估致瘤病毒和非致瘤病毒在牙源性囊肿和肿瘤中的患病率。在没有日期限制的指导下，对所有牙源性囊肿和肿瘤中存在病毒的已发表文章进行了全面的数据库检索，并在PROSPERO进行了登记。在筛选164篇文献后，纳入24项研究进行系统评价。通过荟萃分析确定人乳头瘤病毒（HPV）的患病率，发现成釉细胞瘤中HPV的总总患病率为18.21%(95%可信区间[CI]: 6.36-33.73)，而牙源性囊肿中HPV的患病率为1.51% （95% CI: 0.00-9.46）。Epstein-Barr病毒在牙源性肿瘤中的患病率为17.19% （95% CI: 4.62 ~ 34.49）。其他病毒产生了不同的结果。人类致癌性以前被认为与病毒呈正相关；然而，本系统综述的结果表明，牙源性疾病的患病率非常低，并表明其在病因学中的作用有限。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊