Symmetrical Peripheral Gangrene Associated with Plasmodium Vivax Malaria: A case report with a brief review of literature.

Q3 Medicine

Sultan Qaboos University Medical Journal Pub Date : 2025-05-02 DOI:10.18295/2075-0528.2842

Atanu Chandra, Koustav A Shah, Debapratim Ganguly, Rupak Chatterjee, Sugata Dasgupta

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Abstract

Symmetrical peripheral gangrene (SPG) is an exceptionally uncommon complication of malaria, predominantly linked with Plasmodium falciparum and mixed infections. We report a 41-year-old female who presented to a tertiary care centre of eastern India in 2022 with complaint of fever with chills and rigor for 4 days along with pain and acrocyanosis of distal portions of bilateral upper and lower limbs for last 2 days. Investigations revealed anaemia and neutrophilic leucocytosis with thrombocytopaenia. The peripheral smear revealed trophozoites of P. vivax and the malaria rapid diagnostic test confirmed the presence of P. vivax antigen. D-dimer and fibrin degradation product was elevated and prothrombin time and activated partial thromboplastin time were prolonged; arterial colour doppler of all 4 extremities were within normal limits. A diagnosis of P. vivax malaria was made complicated with disseminated intravascular coagulation leading to SPG.

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间日疟原虫引起的对称外周坏疽：1例报告并附文献综述。

对称外周坏疽（SPG）是一种极为罕见的疟疾并发症，主要与恶性疟原虫和混合感染有关。我们报告一名41岁女性，她于2022年在印度东部的三级保健中心就诊，主诉发热、发冷和僵直4天，并在最后2天出现双侧上肢和下肢远端疼痛和肢端紫绀。调查显示贫血和中性粒细胞增多伴血小板减少症。外周涂片显示间日疟原虫滋养体，疟疾快速诊断试验证实存在间日疟原虫抗原。d -二聚体和纤维蛋白降解产物升高，凝血酶原时间和部分凝血活酶活化时间延长；四肢动脉彩色多普勒检查均在正常范围内。诊断间日疟原虫疟疾合并播散性血管内凝血导致SPG。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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