Supportive Care in Cancer最新文献

{"title":"Dissemination planning in exercise oncology trials-a systematic review of trial protocols.","authors":"Emily Smyth, Lydia Politi, Emer Guinan, David Mockler, Linda O'Neill","doi":"10.1007/s00520-025-09532-4","DOIUrl":"https://doi.org/10.1007/s00520-025-09532-4","url":null,"abstract":"<p><strong>Purpose: </strong>The paucity of exercise rehabilitation services for cancer survivors indicates a research-to-practice gap. Dissemination and Implementation research addresses this gap by focusing on the adoption, implementation, and sustainability of evidence-based interventions. Dissemination, the active process of sharing research findings, is critical to the implementation of evidence-based practice. This systematic review examined adherence of exercise oncology trial protocols to the SPIRIT 2013 checklist items pertaining to dissemination planning, items 31a, 31b, and 31c, which address how dissemination is planned, authorship eligibility is considered, and what plans are in place to share data and the protocol.</p><p><strong>Methods: </strong>A systematic review was conducted following the PRISMA guidelines. EMBASE, MEDLINE, CINAHL, Web of Science-Core Collection, Google Scholar, and the Central Trial Registry via Cochrane were searched (16/05/2024). Title and abstract screening, full-text review, and data extraction were completed in duplicate.</p><p><strong>Results: </strong>Eighty-six trial protocols were included, thirty-one (36.1%) did not report dissemination plans. Item 31 was reported as follows (n = number of trials, frequency (%)); 31a plans to communicate trial results to: participants (n = 19, 22.1%), healthcare professionals (n = 43, 50%), the public (n = 25, 29.2%), and other relevant groups (n = 22, 25.6%), 31b: author eligibility (n = 3, 3.5%) and plans regarding use of professional writers (n = 4, 4.7%), and 31c plans for granting access to participant level dataset (n = 28, 32.6%), full protocol (n = 1, 1.2%) and statistical code (n = 1, 1.2%). Peer-reviewed journal (n = 41, 47.67%) and conferences/professional meetings (n = 38, 44.2%) were the most frequently reported planned dissemination strategies.</p><p><strong>Conclusion: </strong>Reporting of the SPIRIT 2013 checklist Item 31 is generally low in exercise oncology trial protocols. Greater consideration of dissemination planning is required to support the implementation of exercise oncology research into practice.</p><p><strong>Registration: </strong>https://doi.org/10.17605/OSF.IO/M8HFP.</p>","PeriodicalId":22046,"journal":{"name":"Supportive Care in Cancer","volume":"33 6","pages":"473"},"PeriodicalIF":2.8,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12078369/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144080764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The experience and needs of self-care in elderly colorectal cancer stoma patients: a qualitative study.","authors":"Yan Xue, Kaili Lv, Chenye Yuan, Guidi Fan, Ping Yu","doi":"10.1007/s00520-025-09530-6","DOIUrl":"https://doi.org/10.1007/s00520-025-09530-6","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to describe the real experiences and needs of stoma self-care in elderly colorectal cancer patients, providing a theoretical basis for healthcare professionals to develop effective intervention measures.</p><p><strong>Methods: </strong>Semi-structured, in-depth interviews were conducted with the thirteen elderly colorectal cancer patients with stomas. These interviews were audio-recorded and transcribed verbatim. The interview data were then organized, analyzed, and thematically refined using Colaizzi's 7-step analysis method.</p><p><strong>Results: </strong>This study extracted three overarching themes and seven corresponding sub-themes. Theme one, actively seeking help, encompassed pre-rehabilitation needs, social support needs, and continuity of care needs. Theme two, new challenges posed by stomas, included sub-themes related to changes in daily life and psychological burdens. Theme three, courageous acceptance and proactive coping, comprised cognitive changes and behavioral changes as its sub-themes.</p><p><strong>Conclusion: </strong>The study's findings suggest that inadequate in-hospital stoma care education and a lack of continuity of care at home can result in heightened challenges for elderly patients. Healthcare professionals should implement a personalized, full-process education program tailored to geriatric patients' specific needs, ensuring seamless care transition and coordinated management between hospital and home environments.</p>","PeriodicalId":22046,"journal":{"name":"Supportive Care in Cancer","volume":"33 6","pages":"474"},"PeriodicalIF":2.8,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144079808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the usefulness of protocol-based magnesium supplementation for hypomagnesemia in patients with advanced or recurrent colorectal cancer treated with panitumumab.","authors":"Daisuke Ito, Hiroki Asano, Michio Kimura, Eiseki Usami","doi":"10.1007/s00520-025-09531-5","DOIUrl":"https://doi.org/10.1007/s00520-025-09531-5","url":null,"abstract":"<p><strong>Purpose: </strong>Panitumumab (Pmab) is associated with a higher incidence and severity of hypomagnesemia compared to cetuximab, necessitating appropriate monitoring and management strategies. This study aimed to evaluate the efficacy of protocol-based magnesium (Mg) supplementation for treating hypomagnesemia in patients with advanced or recurrent colorectal cancer receiving Pmab.</p><p><strong>Methods: </strong>In this retrospective study, patients with colorectal cancer treated with Pmab between October 2010 and September 2023 were divided into two groups: the pre-protocol group (n = 30) and the post-protocol group (n = 30). The incidence of hypomagnesemia was compared between the groups. The hypomagnesemia management protocol included Mg supplementation at grade 1 (< LLN-1.2 mg/dL), initially with 20 mL (1 mEq/mL) of Mg sulfate injection. If Mg levels continued to decrease despite supplementation, the dose was increased to 40 mL (1 mEq/mL).</p><p><strong>Results: </strong>No significant difference was observed in the frequency of hypomagnesemia between the pre-protocol (56.7%, 17/30) and post-protocol (53.3%, 16/30) groups (P = 1.000). However, the incidence of grade 3 or higher hypomagnesemia was significantly lower in the post-protocol group than in the pre-protocol group (3.3%, 1/30 vs. 30.0%, 9/30; P = 0.012). The rate of deterioration from grade 1 to grade 3 or higher in patients who received Mg supplementation was significantly lower in the post-protocol group than in the pre-protocol group (6.3%, 1/16 vs. 60.0%, 9/15; P = 0.002).</p><p><strong>Conclusion: </strong>Early Mg supplementation effectively reduced the incidence of severe hypomagnesemia, highlighting the utility of this protocol in managing hypomagnesemia in Pmab-treated patients.</p>","PeriodicalId":22046,"journal":{"name":"Supportive Care in Cancer","volume":"33 6","pages":"472"},"PeriodicalIF":2.8,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144047121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quality of life and appraisal factors of patients with advanced cancer and their family caregivers.","authors":"Jia Liu, Yuexia Zhang, Ting Guan, Xiaomeng Wang, Chunxuan Ma, Laurel Northouse, Lixin Song","doi":"10.1007/s00520-025-09512-8","DOIUrl":"10.1007/s00520-025-09512-8","url":null,"abstract":"<p><strong>Purpose: </strong>Few existing interventions have effectively improved the quality of life (QOL) for patients with advanced cancer and their caregivers, partly due to limited research on the factors associated with QOL. Guided by an adapted stress-coping model, this study aimed to examine the associations between the QOL of cancer patients and their caregivers and their primary and secondary appraisals. Primary appraisals involve perceptions and evaluations of advanced cancer and related caregiving, while secondary appraisals relate to their available resources and coping capabilities.</p><p><strong>Methods: </strong>Using multi-level modeling, we conducted a secondary analysis of the baseline data collected from a randomized clinical trial that examined the effects of a family-based, psychoeducational support program for patients with advanced cancer and their caregivers (N = 362 dyads).</p><p><strong>Results: </strong>The appraisal variables hypothesized in the adapted stress-coping model explained 74.14% of the variance in the QOL of patients with advanced cancer and their caregivers when controlling for demographics and other disease-related variables. Better QOL in patients and caregivers was associated with less negative appraisals of illness/caregiving, less uncertainty and hopelessness, less avoidant coping strategies, more family support, more health behaviors, higher self-efficacy, and more active coping strategies.</p><p><strong>Conclusion: </strong>Our study highlights the significant impact that advanced cancer has on patients and their caregivers' perceptions, responses to the illness, and QOL. Future interventions may benefit from addressing illness/caregiving appraisals, uncertainty, hopelessness, family support, health behaviors, self-efficacy, and coping strategies. However, further research is needed to determine the effectiveness of interventions specifically targeting these factors.</p>","PeriodicalId":22046,"journal":{"name":"Supportive Care in Cancer","volume":"33 6","pages":"471"},"PeriodicalIF":2.8,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12078350/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144062257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The experience of subjective financial distress on cancer patients in China: A qualitative study.","authors":"Tianying Yao, Linglong Liu, Xiaoxuan Li, Mingxia Chen, Lihua Lu","doi":"10.1007/s00520-025-09498-3","DOIUrl":"https://doi.org/10.1007/s00520-025-09498-3","url":null,"abstract":"<p><strong>Purpose: </strong>To explore the experience of Chinese cancer patients with SFD (Subjective Financial Distress), and add new evidence to studies on the SFD of cancer.</p><p><strong>Methods: </strong>Cancer patients and caregivers hospitalized in the oncology department of a Grade A hospital in Jiangsu Province from August 2022 to October 2022 were recruited as participants for semi-structured interviews using purposeful sampling and the maximum variation principle. The themes were extracted using Colaizzi's phenomenological data analysis method.</p><p><strong>Results: </strong>The interview involved 24 participants who qualified, comprising 15 patients and 9 caregivers. A total of 3 themes and 9 sub-themes were extracted from interviews: (1) financial risk perception (increasing objective financial burden, decreasing financial accessibility); (2) coping behaviors (changes in daily consumption patterns, changes in work status, changes in treatment plans, and seeking support); (3) negative psychological response (personal dimension, family dimension, and social dimension).</p><p><strong>Conclusion: </strong>SFD is widely present in Chinese cancer families and is being dealt with passively, which adversely affects the lives or work of cancer families. Healthcare professionals should pay attention to this phenomenon and conduct early and comprehensive assessments so that future interventions can be implemented to alleviate their SFD.</p>","PeriodicalId":22046,"journal":{"name":"Supportive Care in Cancer","volume":"33 6","pages":"470"},"PeriodicalIF":2.8,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144049759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of renal function on non-hematologic toxicities in mCRC patients treated with TAS-102: a post-hoc analysis of the JASCC-CINV2001 study.","authors":"Hironori Fujii, Masami Tsuchiya, Daichi Watanabe, Miki Chin, Daisuke Hirate, Katsuyuki Takahashi, Makiko Go, Toshihiro Kudo, Kazuhiro Shimomura, Yosuke Ando, Shinya Tani, Takao Takahashi, Katsuhisa Hayashi, Hironobu Hashimoto, Naomi Matsunami, Masaya Takahashi, Akiko Hasegawa, Takashi Uchida, Akiko Kubo, Nobuhisa Matsuhashi, Akio Suzuki, Junichi Nishimura, Naoki Inui, Hirotoshi Iihara","doi":"10.1007/s00520-025-09504-8","DOIUrl":"https://doi.org/10.1007/s00520-025-09504-8","url":null,"abstract":"<p><strong>Purpose: </strong>Although the efficacy of trifluridine/tipiracil hydrochloride (TAS-102) in treating metastatic colorectal cancer (mCRC) is well established, its non-hematologic toxicities in relation to renal function remain unclear. This study aimed to assess the impact of creatinine clearance (Ccr) on non-hematologic toxicities, including nausea and vomiting, in patients with mCRC treated with TAS-102.</p><p><strong>Methods: </strong>This study was conducted as a post-hoc analysis of the JASCC-CINV2001 study, a multicenter observational study of mCRC patients. Using a Cox proportional hazards model, we assessed the relationship between Ccr and nausea or vomiting, and used a generalized estimating equations (GEE) logistic regression model to analyze the association between Ccr and additional toxicities, including fatigue, constipation, diarrhea, insomnia, and dysgeusia. Toxicities were evaluated at weekly intervals over four weeks.</p><p><strong>Results: </strong>Among 100 patients, median Ccr was 80.5 ml/min. The primary analysis showed no significant association between Ccr and nausea or vomiting. However, the secondary analysis revealed a significant link between lower Ccr and the incidence of diarrhea (P = 0.02).</p><p><strong>Conclusion: </strong>These results suggest that although TAS-102-induced nausea and vomiting are not strongly influenced by renal function, decreased renal function increases the risk of diarrhea. Enhanced antiemetic measures may not be necessary for TAS-102 patients with impaired renal function, but monitoring for diarrhea is recommended.</p>","PeriodicalId":22046,"journal":{"name":"Supportive Care in Cancer","volume":"33 6","pages":"469"},"PeriodicalIF":2.8,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144054651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Experience implementing the serious illness care program through virtual training of multidisciplinary teams at a regional cancer centre.","authors":"Russell Leong, Sandra Andreychuk, Cheryl Shoemaker, Georgia Georgiou, Helena Adjekum, Ruth Locis, Adrienne Sultana, Suganya Vadivelu, Oren Levine","doi":"10.1007/s00520-025-09525-3","DOIUrl":"https://doi.org/10.1007/s00520-025-09525-3","url":null,"abstract":"<p><strong>Purpose: </strong>The Serious Illness Care Program (SICP) was launched at the Juravinski Cancer Centre (JCC) to promote early, high-quality goals of care conversations with patients experiencing advanced cancer. Training was provided to multidisciplinary disease site teams (DSTs). The objective of this study is to validate the virtual SICP training format and assess the clinician and patient experience after 6 months of implementation.</p><p><strong>Methods: </strong>Clinicians completed SICP training through a virtual workshop on Zoom and responded to surveys describing their experience before and after the training. Clinicians then completed a validated survey 6 months later, describing their experience of implementing serious illness conversations (SIC) into practice. Consenting patients were contacted within 2 weeks of a SIC encounter and responded to validated questions about their experience.</p><p><strong>Results: </strong>Training was provided to 52 healthcare providers in the breast, lung and brain malignancy DSTs. Overall, the virtual training format was well received. Training could be improved by allowing more time to practice skills and including more video examples. By 6 months, 39% of clinicians reported conducting SIC. Most users reported that SIC helps them understand patient goals. Among non-users, insufficient time was the most cited barrier. Nurses in a non-primary care model reported difficulty engaging in SIC. Most patients felt that SIC was a worthwhile experience.</p><p><strong>Conclusion: </strong>Our study demonstrates the feasibility of the virtual SICP implementation process. Additionally, SICP was successfully delivered across multidisciplinary DSTs. Training will continue rolling out incrementally for all DSTs at the JCC, exploring the incorporation of self-learning modules.</p>","PeriodicalId":22046,"journal":{"name":"Supportive Care in Cancer","volume":"33 6","pages":"468"},"PeriodicalIF":2.8,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144035488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stakeholder perspectives on the role of caregivers in cancer clinical trial decision-making: results of a qualitative study.","authors":"Eric C Blackstone, Susan R Mazanec, Barbara J Daly, Jennifer A Dorth, Alberto J Montero, Mark P Aulisio, Patricia T Brandt, Helen Foley, Sana Loue","doi":"10.1007/s00520-025-09505-7","DOIUrl":"https://doi.org/10.1007/s00520-025-09505-7","url":null,"abstract":"<p><strong>Purpose: </strong>Family caregivers assist cancer patients in making medical decisions, yet their roles in clinical trial decisions remain understudied. This study aimed to determine how caregivers participate in clinical trial decisions from the perspectives of both caregivers and research staff.</p><p><strong>Methods: </strong>Family caregivers of patients offered participation in a clinical trial and clinical trial staff were recruited for focus groups and semi-structured interviews. Participants were asked about caregiver roles in clinical trial decisions and practices of staff to include caregivers during the informed consent process.</p><p><strong>Results: </strong>Qualitative analysis revealed these caregiver themes: promoting patient autonomy, influential factors, and burdens of participation. Themes specific to clinical trial staff included the following: caregiver role in decision, approaches to caregiver inclusion, caregiver utility to trial staff, and navigating challenging situations. Caregivers reported helping patients make better decisions without influencing them, while clinical trial staff viewed caregivers as highly influential. The hope for therapeutic benefit was a strong motivator for caregivers to support participation in the trial despite burdens they encountered. Clinical trial staff found caregivers to be useful in facilitating communication and adherence to the study protocol.</p><p><strong>Conclusion: </strong>Caregivers should be included early in clinical trial discussions due to their key role in decision-making and facilitating adherence. Clinical trial staff would benefit from training on communication with caregivers and identifying support to alleviate caregiver burden. The cancer research community should explore ways to decrease caregiver burden when possible or provide compensation when caregivers sacrifice time and effort to facilitate clinical trial participation.</p>","PeriodicalId":22046,"journal":{"name":"Supportive Care in Cancer","volume":"33 6","pages":"464"},"PeriodicalIF":2.8,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144054652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors influencing the decision to discontinue treatment due to chemotherapy-induced peripheral neuropathy among patients with metastatic breast cancer: a best-worst scaling.","authors":"Rotana M Radwan, John F P Bridges, Daniel L Hertz, Maryam B Lustberg, Hetal Vachhani, Erin Hickey Zacholski, Vanessa B Sheppard, Teresa M Salgado","doi":"10.1007/s00520-025-09508-4","DOIUrl":"https://doi.org/10.1007/s00520-025-09508-4","url":null,"abstract":"<p><strong>Purpose: </strong>To measure the importance of factors that influence the decision to discontinue treatment due to chemotherapy-induced peripheral neuropathy (CIPN) among patients with metastatic breast cancer (mBC).</p><p><strong>Methods: </strong>An online survey incorporating a best-worst scaling (BWS) was conducted among women in the USA with mBC and experiencing CIPN. In the BWS, women chose the most and least important factors influencing their decision to discontinue treatment due to CIPN. Seven factors were included: relieving current neuropathy symptoms, reducing risk of long-term neuropathy, having another cancer treatment option, understanding the risk of treatment discontinuation, and receiving support for treatment discontinuation from the oncologist, loved ones, or patients with similar experiences. To measure the importance of each factor, a conditional logit model estimated coefficients, which were subsequently rescaled to importance scores that summed to 100. The dependent variable was the choice of a factor as most or least important across seven choice tasks.</p><p><strong>Results: </strong>The sample included 189 women with a mean age of 52.5 (SD = 12.65) years, 52.9% were White, 33.9% were Black, and 64.6% held a bachelor's degree or higher. When faced with the decision to discontinue treatment due to CIPN, the most important factors were having another cancer treatment option (score 23.5), followed by understanding the risk of treatment discontinuation (score 19.2), and reducing risk of long-term neuropathy (score 19.1). The least important factors in the decision to discontinue treatment due to CIPN were: support from loved ones (score 5.2) and support from other patients (score 3.3).</p><p><strong>Conclusion: </strong>When faced with the decision to discontinue treatment due to CIPN, women with mBC attributed more importance to survival and reducing the risk of long-term CIPN. Knowledge of what matters most to patients may assist with shared decision-making to optimize therapeutic outcomes in patients receiving neurotoxic chemotherapy.</p>","PeriodicalId":22046,"journal":{"name":"Supportive Care in Cancer","volume":"33 6","pages":"467"},"PeriodicalIF":2.8,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12065726/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144011202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A systematic review on the effects of logotherapy and meaning-centered therapy on psychological and existential symptoms in women with breast and gynecological cancer.","authors":"Andrea Aiello-Puchol, Joaquín García-Alandete","doi":"10.1007/s00520-025-09519-1","DOIUrl":"https://doi.org/10.1007/s00520-025-09519-1","url":null,"abstract":"<p><strong>Purpose: </strong>Women diagnosed with breast cancer (BC) and gynecological cancer (GC) face psychological and existential challenges common to all cancers, such as anxiety and depression, along with specific issues related to body image and sexuality. Logotherapy and meaning-centered therapy (MCT) have shown positive effects on the psychological well-being of cancer patients.</p><p><strong>Methods: </strong>A systematic review was conducted following PRISMA guidelines to assess the impact of logotherapy and meaning-centered therapy (MCT) on women diagnosed with BC and GC from January 2014 to December 2024. Empirical research articles published in English were included, while literature reviews, meta-analyses, doctoral theses, preprints, books, and studies involving other cancer types or metastatic/comorbid conditions were excluded. The search was conducted across Web of Science, Scopus, and PubMed databases using terms like uterine cancer, ovarian cancer, breast cancer, mastectomy, logotherapy, and MCT. The Boolean operators AND and OR were used in the Title and Abstract search fields across all three databases, as well as in the Topic search field for the WoS database.</p><p><strong>Results: </strong>Out of the 36 articles initially obtained, 29 remained after eliminating duplicates and, finally, six papers were selected. The included studies examined various psychological and existential issues in patients with breast and gynecological cancer, including anxiety, distress, depression, hopelessness, death anxiety, post-traumatic stress, perception of physical symptoms, quality of life, post-traumatic growth, spiritual well-being, and meaning in life.</p><p><strong>Conclusion: </strong>Findings suggest that logotherapy decreases depressive symptoms, anxiety, and post-traumatic stress, whereas improves meaning in life, quality of life, physical symptom perception, and post-traumatic growth in women with BC and GC. Implementing logotherapy in cancer care units through a multidisciplinary approach could be valuable, considering biopsychosocial factors, and incorporating aspects of self-image and sexuality in treatment would also be beneficial.</p>","PeriodicalId":22046,"journal":{"name":"Supportive Care in Cancer","volume":"33 6","pages":"465"},"PeriodicalIF":2.8,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12065743/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144042709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}