Supportive Care in Cancer最新文献

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KRAS-G12 inhibitors in lung cancer therapy: unveiling the toxicity profile through a pharmacovigilance study. 肺癌治疗中的 KRAS-G12 抑制剂:通过药物警戒研究揭示毒性概况。
IF 2.8 3区 医学
Supportive Care in Cancer Pub Date : 2024-11-21 DOI: 10.1007/s00520-024-09024-x
Wenjie Li, Wei Wang
{"title":"KRAS-G12 inhibitors in lung cancer therapy: unveiling the toxicity profile through a pharmacovigilance study.","authors":"Wenjie Li, Wei Wang","doi":"10.1007/s00520-024-09024-x","DOIUrl":"https://doi.org/10.1007/s00520-024-09024-x","url":null,"abstract":"<p><strong>Background: </strong>With the advent of drugs designed to selectively target the KRAS-G12C mutant protein, sotorasib and adagrasib have exhibited remarkable efficacy in patients with KRAS G12C mutant lung cancers. Nevertheless, the safety profiles of these agents in a real-world context remain undisclosed.</p><p><strong>Methods: </strong>Data was systematically extracted from the FDA Adverse Event Reporting System (FAERS) website from January 2021 to December 2023, focusing on adverse events associated with KRAS G12C inhibitors, sotorasib and adagrasib.</p><p><strong>Results: </strong>The predominant adverse events attributed to KRAS G12C inhibitors predominantly encompassed general disorders and administration site conditions, investigations, and gastrointestinal disorders. Among these, the significant adagrasib-related adverse events comprised nausea, diarrhea, vomiting, asthenia, dizziness, and weight loss. Notably, incidences of renal failure were also documented in patients receiving adagrasib. Conversely, the primary adverse events associated with sotorasib included diarrhea, nausea, abnormal hepatic function, elevated levels of aspartate aminotransferase and alanine aminotransferase, and hepatotoxicity. It is noteworthy that a considerable number of adverse events manifested within the inaugural month following the initiation of therapy with KRAS G12C inhibitors.</p><p><strong>Conclusion: </strong>Although most adverse effects are reversible, vigilance is warranted particularly for nephrotoxicity and hepatotoxicity during the administration of KRAS G12C inhibitors.</p>","PeriodicalId":22046,"journal":{"name":"Supportive Care in Cancer","volume":"32 12","pages":"812"},"PeriodicalIF":2.8,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142682752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Streptococcus pneumoniae and influenza vaccination rates in oncological patients - data from Germany. 肿瘤患者的肺炎链球菌和流感疫苗接种率 - 来自德国的数据。
IF 2.8 3区 医学
Supportive Care in Cancer Pub Date : 2024-11-21 DOI: 10.1007/s00520-024-09023-y
Emma Niederstein, Journey Underwood, Maike de Wit, Mark Reinwald, Sandra Schwarzlose-Schwarck, Werner Dammermann, P Markus Deckert, Til Ramón Kiderlen
{"title":"Streptococcus pneumoniae and influenza vaccination rates in oncological patients - data from Germany.","authors":"Emma Niederstein, Journey Underwood, Maike de Wit, Mark Reinwald, Sandra Schwarzlose-Schwarck, Werner Dammermann, P Markus Deckert, Til Ramón Kiderlen","doi":"10.1007/s00520-024-09023-y","DOIUrl":"https://doi.org/10.1007/s00520-024-09023-y","url":null,"abstract":"<p><strong>Objectives: </strong>Due to disease- or therapy-associated immunosuppression, oncological patients suffer from significantly higher morbidity and mortality due to infections transmitted by respiratory pathogens such as Streptococcus pneumoniae and influenza virus. Although the German Standing Committee on Vaccination (STIKO) provides specific recommendations for vaccination against these pathogens, there is no data on vaccination rates in this high-risk population.</p><p><strong>Methods: </strong>Data from the interventional EVO study were analyzed to provide information on vaccination rates against Streptococcus pneumoniae and influenza virus in oncological patients. Numbers presented in this publication summarize baseline and follow-up data of the control group; thus, data were not influenced by the intervention.</p><p><strong>Results: </strong>Data of 370 patients were analyzed; 20.5% of patients were treated for hematological malignancies and 79.5% for solid cancer. 28.1% of patients had received vaccination against influenza and 32.2% against Streptococcus pneumoniae; for the latter only 7.3% according recommendations. While vaccination rates where even lower for patients with thoracic carcinoma (influenza 26.7% and Streptococcus pneumoniae 6.0% according to STIKO recommendations), rates in patients with multiple myeloma were remarkably higher (39.0% and 14.6%).</p><p><strong>Conclusions: </strong>Despite strong recommendations to vaccinate and the clear clinical need to prevent infections in the vulnerable group of oncological patients, only the minority was vaccinated against Streptococcus pneumoniae or influenza, underlining the urgent need for better vaccination strategies in this high-risk population.</p>","PeriodicalId":22046,"journal":{"name":"Supportive Care in Cancer","volume":"32 12","pages":"813"},"PeriodicalIF":2.8,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142682767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Perceptions, facilitators, and barriers of participation for a behavioral weight loss group-based telehealth program for breast cancer survivors: a qualitative study. 乳腺癌幸存者参与基于行为减肥小组的远程保健计划的看法、促进因素和障碍:一项定性研究。
IF 2.8 3区 医学
Supportive Care in Cancer Pub Date : 2024-11-20 DOI: 10.1007/s00520-024-08999-x
Yangzi Liu, Elizabeth De Jesus, Macy Goldbach, Robert S Krouse, Carmen E Guerra, Katharine A Rendle, Tamara J Cadet, Kelly C Allison, Julia Tchou
{"title":"Perceptions, facilitators, and barriers of participation for a behavioral weight loss group-based telehealth program for breast cancer survivors: a qualitative study.","authors":"Yangzi Liu, Elizabeth De Jesus, Macy Goldbach, Robert S Krouse, Carmen E Guerra, Katharine A Rendle, Tamara J Cadet, Kelly C Allison, Julia Tchou","doi":"10.1007/s00520-024-08999-x","DOIUrl":"https://doi.org/10.1007/s00520-024-08999-x","url":null,"abstract":"<p><strong>Purpose: </strong>Results from the pilot Group-basEd Telehealth behavioral Weight Loss (GET-WEL) Program (NCT04855552) showed that fewer Black breast cancer survivors (BCS) enrolled than White BCS. Black participants also lost less weight than White participants. Little is known about mitigating factors or how best to implement such programs equitably. In this study, we explored facilitators and barriers in Black and White BCS who did or did not participate in GET-WEL.</p><p><strong>Methods: </strong>BCS who are overweight or obese (body mass index (BMI) ≥ 25 kg/m<sup>2</sup>) and who had previously been assessed for their willingness to participate in GET-WEL were invited to participate in a semi-structured telephone interview conducted from June to August 2023. Interviewees were purposefully sampled from those who did (participants) and did not (non-participants) enroll in GET-WEL. Interviews were coded and analyzed via comparative thematic analysis.</p><p><strong>Results: </strong>Of the 24 interviewees, 9 (8 White, 1 Black) were GET-WEL participants, and 15 (8 White, 6 Black, 1 Asian) were non-participants. There were no thematic differences between Black and White BCS. Most non-participants lacked awareness that the Program was recruiting. Program accountability, session flexibility, and pre-existing exercise routines emerged as facilitators while inability to identify enjoyable physical activities, difficulty accessing healthy foods, and competing work/life priorities emerged as barriers.</p><p><strong>Conclusion: </strong>Our results suggest that enhancing Program awareness and outreach may increase enrollment in minoritized BCS. Resources providing healthy foods and support to ease competing work/life priorities may help BCS maintain healthy lifestyles during and after GET-WEL. These results may help inform future large-scale GET-WEL implementation.</p>","PeriodicalId":22046,"journal":{"name":"Supportive Care in Cancer","volume":"32 12","pages":"808"},"PeriodicalIF":2.8,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142682756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Incidence and impact of food aversions among patients with cancer receiving outpatient chemotherapy: a one-year prospective survey. 接受门诊化疗的癌症患者食物厌恶的发生率和影响:为期一年的前瞻性调查。
IF 2.8 3区 医学
Supportive Care in Cancer Pub Date : 2024-11-20 DOI: 10.1007/s00520-024-09028-7
Machi Suka, Atsushi Katsube, Reiko Fujimoto, Tadashi Uwagawa, Takashi Shimada, Shingo Yano, Takashi Yamauchi, Hiroyuki Yanagisawa
{"title":"Incidence and impact of food aversions among patients with cancer receiving outpatient chemotherapy: a one-year prospective survey.","authors":"Machi Suka, Atsushi Katsube, Reiko Fujimoto, Tadashi Uwagawa, Takashi Shimada, Shingo Yano, Takashi Yamauchi, Hiroyuki Yanagisawa","doi":"10.1007/s00520-024-09028-7","DOIUrl":"https://doi.org/10.1007/s00520-024-09028-7","url":null,"abstract":"<p><strong>Purpose: </strong>To determine the current incidence and impact of chemotherapy-associated food aversions in a variety of cancer types.</p><p><strong>Methods: </strong>Cancer patients aged 18 years and older who received chemotherapy infusions at the outpatient chemotherapy unit of a university hospital between May 2022 and April 2023 were included in the study (n = 243). To monitor the occurrence of food aversions, participants were asked to complete a food preference questionnaire each time they visited the outpatient chemotherapy unit.</p><p><strong>Results: </strong>During the one-year survey period, one in four cancer patients receiving outpatient chemotherapy developed food aversions, and one in four of them complained of interference with daily life due to eating problems at the same time or later. The median time to the onset of food aversion was 46 (interquartile range 36-77) days after the start of chemotherapy. The incidence of food aversions was significantly higher in patients who were women, had a digestive, gynecologic, or breast cancer, and received more cytotoxic agents in chemotherapy. Patients who developed food aversions tended to lose more body weight than those who did not.</p><p><strong>Conclusion: </strong>Food aversions were still common among cancer patients undergoing chemotherapy. Even an aversion to a single food may have affected the patient's nutritional status. Healthcare professionals should closely monitor the occurrence of food aversions, especially in the early days of chemotherapy induction, to detect an increasing risk of malnutrition.</p><p><strong>Trial registration: </strong>Not applicable.</p>","PeriodicalId":22046,"journal":{"name":"Supportive Care in Cancer","volume":"32 12","pages":"810"},"PeriodicalIF":2.8,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142682587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Relationship among cancer treatment, quality of life, and oral function in head and neck cancer survivors: A cross-sectional study. 头颈部癌症幸存者的癌症治疗、生活质量和口腔功能之间的关系:横断面研究
IF 2.8 3区 医学
Supportive Care in Cancer Pub Date : 2024-11-20 DOI: 10.1007/s00520-024-09015-y
Aya Yokoi, Takayuki Maruyama, Reiko Yamanaka, Noriko Takeuchi, Manabu Morita, Daisuke Ekuni
{"title":"Relationship among cancer treatment, quality of life, and oral function in head and neck cancer survivors: A cross-sectional study.","authors":"Aya Yokoi, Takayuki Maruyama, Reiko Yamanaka, Noriko Takeuchi, Manabu Morita, Daisuke Ekuni","doi":"10.1007/s00520-024-09015-y","DOIUrl":"https://doi.org/10.1007/s00520-024-09015-y","url":null,"abstract":"<p><strong>Purpose: </strong>Treatment for head and neck cancer (HNC), such as surgery and chemoradiotherapy, can reduce oral function and affect quality of life (QoL). However, whether HNC treatment affects QoL via the decline of oral function remains unclear. This study aimed to investigate the relationship among cancer treatment, QoL, and actual oral function in HNC survivors.</p><p><strong>Methods: </strong>A total of 100 HNC survivors who had completed definitive treatment for HNC at least 6 months prior to enrollment were enrolled in this cross-sectional study. QoL was evaluated using the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-Core 30 summary score. Oral diadochokinesis (ODK), tongue pressure, moisture level on the mucosal surface, and mouth opening were measured. Information on age, sex, tumor site, tumor stage, history of HNC treatment, height, body weight, and lifestyle were collected from medical records. Structural equation modeling (SEM) was conducted to analyze the indirect/direct associations among HNC treatment, QoL, and oral function.</p><p><strong>Results: </strong>In total, 100 HNC survivors (58 males and 42 females; age range, 30-81 years, median, 67 years) were analyzed. Overall, 63 patients (63.0%) were diagnosed as oral cancer, 66 (66.0%) developed advanced cancer (stage 3/4), and 58 (58.0%) underwent reconstruction surgery in 100 HNC survivors. The SEM results supported the hypothesized structural model (root mean square error of approximation = 0.044, comparative fit index = 0.990, Tucker-Lewis index = 0.986). Surgery with neck dissection and reconstruction for advanced cancer had indirect effects on lower QoL via ODK and mouth opening.</p><p><strong>Conclusion: </strong>HNC treatment is indirectly associated with QoL via oral function in HNC survivors.</p>","PeriodicalId":22046,"journal":{"name":"Supportive Care in Cancer","volume":"32 12","pages":"809"},"PeriodicalIF":2.8,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142682760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluating pain management practices for cancer patients among health professionals in cancer and supportive/palliative care units: a Belgian survey. 评估癌症和支持/姑息治疗科室医护人员对癌症患者的疼痛管理方法:比利时调查。
IF 2.8 3区 医学
Supportive Care in Cancer Pub Date : 2024-11-20 DOI: 10.1007/s00520-024-08984-4
Christel Fontaine, Isabelle Libert, Marie-Aline Echterbille, Vincent Bonhomme, Jacky Botterman, Bram Bourgonjon, Vincent Brouillard, Yannick Courtin, Joke De Buck, Philip R Debruyne, Martine Delaat, Jean-Michel Delperdange, Lionel Duck, Els Everaert, Caroline Lamot, Stéphane Holbrechts, Dominique Lossignol, Francis Krekelbergh, Christine Langenaeken, Lore Lapeire, Eline Naert, Koen Lauwers, Milica Matic, Jeroen Mebis, Geertje Miedema, Michèle Pieterbourg, Barbara Plehiers, Kevin Punie, Françoise Roblain, Dirk Schrijvers, Charles-Henri Serre, Katherine Vandenborre, Anne Vanden Broecke, Heidi Van den Bulk, Ludo Vanopdenbosch, Florence Van Ryckeghem, Jolanda Verheezen, Vincent Verschaeve, Mia Voordeckers, Jean Klastersky
{"title":"Evaluating pain management practices for cancer patients among health professionals in cancer and supportive/palliative care units: a Belgian survey.","authors":"Christel Fontaine, Isabelle Libert, Marie-Aline Echterbille, Vincent Bonhomme, Jacky Botterman, Bram Bourgonjon, Vincent Brouillard, Yannick Courtin, Joke De Buck, Philip R Debruyne, Martine Delaat, Jean-Michel Delperdange, Lionel Duck, Els Everaert, Caroline Lamot, Stéphane Holbrechts, Dominique Lossignol, Francis Krekelbergh, Christine Langenaeken, Lore Lapeire, Eline Naert, Koen Lauwers, Milica Matic, Jeroen Mebis, Geertje Miedema, Michèle Pieterbourg, Barbara Plehiers, Kevin Punie, Françoise Roblain, Dirk Schrijvers, Charles-Henri Serre, Katherine Vandenborre, Anne Vanden Broecke, Heidi Van den Bulk, Ludo Vanopdenbosch, Florence Van Ryckeghem, Jolanda Verheezen, Vincent Verschaeve, Mia Voordeckers, Jean Klastersky","doi":"10.1007/s00520-024-08984-4","DOIUrl":"https://doi.org/10.1007/s00520-024-08984-4","url":null,"abstract":"<p><strong>Background: </strong>Pain is reported in 66% of cancer patients with advanced disease. Adequate pain management is a cornerstone of comprehensive supportive cancer care.</p><p><strong>Purpose: </strong>The purpose of this study was to assess pain management in Oncology Units in Belgium.</p><p><strong>Methods: </strong>A descriptive research design was applied. A structured questionnaire developed by a writing committee was sent to 37 healthcare professionals in 2021. Twenty-four replied.</p><p><strong>Results: </strong>In most centers, pain management is organized through the pain clinic (91.7%), followed by a multidisciplinary team (83.3%) and the palliative care unit (75%). Eighty-seven percent use tools to assess the pain, mostly for in-patients. Pain guidelines are applied in 17 centers with the ESMO guidelines being the most often mentioned. Mild to moderate pain is managed with paracetamol, non-steroidal anti-inflammatory drugs, and tramadol. All centers handle severe pain with strong opioids, including buprenorphine and fentanyl. Only 62% are concerned about the side effects of strong opioids. In case of neuropathic pain, treatments with pregabalin, gabapentine, and tricyclic antidepressants are the most common, followed by opioids and interventional therapies for refractory neuropathic pain. Asking advice to the pain clinic, combination therapy and opioid rotation are used for patients with inadequate analgesia. Eighty to 90% of the centers have access to intraspinal and epidural techniques, respectively. An active teaching program on pain relief is offered in 66%, but only 33% of the centers do active research focused on pain management.</p><p><strong>Conclusions: </strong>This is the first survey on pain management in the Belgian centers. Surprisingly only one-third of the health professionals ask advice to the pain clinic in case of inadequate pain relief, meaning that we are far away from a multidisciplinary patient-centered approach. Therefore, the BSMO Supportive Care Task Force promotes the development of an interdisciplinary committee in every oncology unit.</p>","PeriodicalId":22046,"journal":{"name":"Supportive Care in Cancer","volume":"32 12","pages":"811"},"PeriodicalIF":2.8,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142682515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The association between an inflammation-based nutritional tool (Glasgow Prognostic Score) and length of hospital stay in patients with haematological cancer. 基于炎症的营养工具(格拉斯哥预后评分)与血液肿瘤患者住院时间的关系。
IF 2.8 3区 医学
Supportive Care in Cancer Pub Date : 2024-11-19 DOI: 10.1007/s00520-024-09021-0
Anqi Song, Beiwen Ni, Molian Tang, Yiquan Zhou, Xiaomin Zhang, Zhiqi Chen, Lijing Shen, Renying Xu
{"title":"The association between an inflammation-based nutritional tool (Glasgow Prognostic Score) and length of hospital stay in patients with haematological cancer.","authors":"Anqi Song, Beiwen Ni, Molian Tang, Yiquan Zhou, Xiaomin Zhang, Zhiqi Chen, Lijing Shen, Renying Xu","doi":"10.1007/s00520-024-09021-0","DOIUrl":"10.1007/s00520-024-09021-0","url":null,"abstract":"<p><strong>Background: </strong>This is a retrospective study to identify if Glasgow Prognostic Score (GPS) is associated with length of hospital stay (LOS) in haematological cancer.</p><p><strong>Methods: </strong>The participants were adult inpatients at a single centre in between 2018 and 2022. Serum levels of CRP and albumin were measured at admission. GPS was calculated as follows: point \"0\" as CRP < 10 mg/L and albumin ≥ 35 g/L; point \"2\" as CRP ≥ 10 mg/L and albumin < 35 g/L; point \"1\" as either CRP ≥ 10 mg/L or albumin < 35 g/L. Patients with point \"0\" were classified as low risk whilst point \"2\" as high risk. LOS was defined as the interval between the admission and discharge date.</p><p><strong>Results: </strong>As a result, the average age was 59.6 ± 12.6 years and the average LOS was 6.0 days (IQR = 2 days, 11 days). Of 1621 patients, 8.8% of them were high risk. GPS was associated with LOS (β = 2.7 days; 95% CI = 0.8 days, 4.6 days; p trend < 0.001) after full adjustment. Each point of GPS was associated with 1.9 days (95% CI = 1.4 days, 2.4 days) longer in LOS with full adjustment. The association was more prominent in younger patients (< 65 years), patients with leukaemia and myelodysplastic syndrome, and those with normal body weight status (18.5-24 kg/m<sup>2</sup>), compared with their counterparts.</p><p><strong>Conclusion: </strong>GPS was associated with LOS in Chinese patients with haematological cancer, indicating GPS could be a useful tool to predict outcome.</p>","PeriodicalId":22046,"journal":{"name":"Supportive Care in Cancer","volume":"32 12","pages":"804"},"PeriodicalIF":2.8,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142669239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Diagnostic trajectories of patients with rare cancer in the Netherlands: results from a nationwide cross-sectional survey. 荷兰罕见癌症患者的诊断轨迹:一项全国性横断面调查的结果。
IF 2.8 3区 医学
Supportive Care in Cancer Pub Date : 2024-11-19 DOI: 10.1007/s00520-024-08998-y
Catarina S Padilla, Eline de Heus, Milou J P Reuvers, Marga Schrieks, Vivian Engelen, Dirk Grunhagen, Margot E T Tesselaar, Winette T A van der Graaf, Saskia F A Duijts, Olga Husson
{"title":"Diagnostic trajectories of patients with rare cancer in the Netherlands: results from a nationwide cross-sectional survey.","authors":"Catarina S Padilla, Eline de Heus, Milou J P Reuvers, Marga Schrieks, Vivian Engelen, Dirk Grunhagen, Margot E T Tesselaar, Winette T A van der Graaf, Saskia F A Duijts, Olga Husson","doi":"10.1007/s00520-024-08998-y","DOIUrl":"10.1007/s00520-024-08998-y","url":null,"abstract":"<p><p>Diagnosing rare cancers is challenging and often leads to prolonged diagnostic trajectories. This study investigated the diagnostic trajectory of patients with rare cancers in The Netherlands. Data from 1541 patients were recruited via patient advocacy in a national online survey on their diagnostic trajectory, such as first general practitioner (GP) consultation to hospital referral and number of hospital visits before final diagnosis. Differences between solid vs. non-solid tumours and EURACAN domains were explored. Diagnostic timelines varied from less than 3 months to over 12 months. Most patients (76.0%) first consulted their GP before going to a hospital. 76.3% of all patients were referred to a hospital within less than 3 months. 32.1% reported receiving an incorrect diagnosis, and 44.6% of them underwent treatment or medication for the (perceived) incorrect diagnosis. Patients with solid vs. non-solid rare cancers trajectories differed significantly for treatment hospital, route to diagnosis, correctness of initial diagnosis, and number of hospital visits before correct diagnosis (all p < 0.001). Patients with neuroendocrine (NET; 21.7%) and endocrine tumours (17.5%) experienced longer GP-to-hospital visit waiting times. Patients with non-solid cancers often received a correct diagnosis after one hospital visit (75%) when compared with patients with solid cancer (2+ = 57.7%). Those with rare skin cancer and non-cutaneous melanoma, head and neck, and thoracic cancer visited multiple hospitals before an accurate diagnosis (56.7%, 53.8%, and 50.0%). Patients with rare cancers face significant challenges with diagnostic delays and inaccuracies. Researching symptom signatures and investing in regional clinical networks might improve diagnostic timelines.</p>","PeriodicalId":22046,"journal":{"name":"Supportive Care in Cancer","volume":"32 12","pages":"807"},"PeriodicalIF":2.8,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142669226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Factors influencing cancer-related fatigue in patients with esophageal cancer undergoing radiotherapy: pathway analysis. 影响接受放射治疗的食管癌患者癌症相关疲劳的因素:路径分析。
IF 2.8 3区 医学
Supportive Care in Cancer Pub Date : 2024-11-19 DOI: 10.1007/s00520-024-09016-x
Yuqing Wang, Xuhan Sun, Shuyu Zhang, Xinyu Lu, Jianchun Xia, Yuxi Zhang
{"title":"Factors influencing cancer-related fatigue in patients with esophageal cancer undergoing radiotherapy: pathway analysis.","authors":"Yuqing Wang, Xuhan Sun, Shuyu Zhang, Xinyu Lu, Jianchun Xia, Yuxi Zhang","doi":"10.1007/s00520-024-09016-x","DOIUrl":"10.1007/s00520-024-09016-x","url":null,"abstract":"<p><strong>Background: </strong>Cancer-related fatigue symptoms persist throughout the radiotherapy period in patients with esophageal cancer and show a continuous worsening trend, which seriously affects the quality of survival of patients. Therefore, monitoring patients' fatigue status promptly, recognizing highly fatigued patients, and providing physical and psychological support are essential for improving their quality of life. As a positive psychological trait, self-efficacy can influence the level of fatigue in patients undergoing radiotherapy for esophageal cancer. However, the pathways by which self-efficacy affects cancer-related fatigue remain unclear.</p><p><strong>Objective: </strong>The aim of this study is to investigate the factors influencing cancer-related fatigue in patients undergoing radiation therapy for esophageal cancer and to investigate the role of social support as a mediator between self-efficacy and cancer-related fatigue using the theory of unpleasant symptoms.</p><p><strong>Methods: </strong>The study used a descriptive survey approach, and data were collected at a tertiary hospital in Nanjing between October 2022 and May 2023. A total of 225 patients with esophageal cancer undergoing radiotherapy completed the Demographic Characteristics Scale, Cancer-Related Fatigue Scale, Self-Efficacy Scale, and Social Support Rating Scale. The data were statistically analyzed using SPSS version 26.0 (IBM, CHINA) and SPSS PROCESS 3.3 plug-in.</p><p><strong>Results: </strong>The cancer-related fatigue score of Chinese patients undergoing radiotherapy for esophageal cancer was 27.27 ± 7.26, which shows a high level of fatigue. Social support partially mediates the relationship between self-efficacy and cancer-related fatigue.</p><p><strong>Conclusion: </strong>The findings may help medical personnel identify factors that influence cancer-related fatigue in patients undergoing radiotherapy for esophageal cancer and develop reasonable management strategies.</p>","PeriodicalId":22046,"journal":{"name":"Supportive Care in Cancer","volume":"32 12","pages":"806"},"PeriodicalIF":2.8,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142669238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Topical use of chicory root extract gel on the incidence and severity of radiodermatitis in breast cancer patients: a randomized controled trial. 外用菊苣根提取物凝胶对乳腺癌患者放射性皮炎发病率和严重程度的影响:随机对照试验。
IF 2.8 3区 医学
Supportive Care in Cancer Pub Date : 2024-11-19 DOI: 10.1007/s00520-024-09017-w
Fatemeh Jafari, Fatemeh Sadat Izadi-Avanji, Mahboubeh Maghami, Mostafa Sarvizadeh
{"title":"Topical use of chicory root extract gel on the incidence and severity of radiodermatitis in breast cancer patients: a randomized controled trial.","authors":"Fatemeh Jafari, Fatemeh Sadat Izadi-Avanji, Mahboubeh Maghami, Mostafa Sarvizadeh","doi":"10.1007/s00520-024-09017-w","DOIUrl":"10.1007/s00520-024-09017-w","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background and purpose: &lt;/strong&gt;Nearly 95% of women treated with radiotherapy for breast cancer experience some degree of radiodermatitis. Radiation therapy's most frequent side effect is skin damage. Managing radiation-induced skin reactions while maintaining treatment continuity is a challenging issue. The chicory plant has known anti-inflammatory properties. This study aimed to assess the effect of chicory root extract gel on the incidence and severity of radiodermatitis in breast cancer patients.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Materials and methods: &lt;/strong&gt;This three-blind clinical trial was conducted in the radiation therapy department of Ayatollah Yasrebi Hospital in Kashan from September 2022 to February 2023. Forty-four breast cancer patients undergoing radiation therapy with a linear accelerator were randomly assigned to either the intervention group (n = 21) or the placebo group (n = 20). Participants applied topically chicory root extract gel or placebo twice daily, starting with their radiation therapy. The incidence and severity of dermatitis were assessed using the Radiation Therapy Oncology Group (RTOG) scale. Participants' characteristics were collected through a researcher-designed questionnaire. Data analysis was performed using chi-square tests, Fisher's exact test, independent t-tests, Mann-Whitney U tests, and generalized linear models with a Poisson distribution, using SPSS version 16 software.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;No significant differences were found between the two groups regarding individual and clinical characteristics at the beginning of the study. The results indicated that the number of patients who did not develop dermatitis in later weeks was higher in the intervention group compared to the placebo group (P &lt; 0.001). In the second and third weeks, grade 1 and 2 dermatitis incidence was higher in the placebo group than in the intervention group (P &lt; 0.001). A comparison of the incidence of dermatitis between the two groups, in terms of the number of days to develop grade 1 dermatitis, showed that the average duration was longer in the intervention group than in the placebo group (P &gt; 0.05). This comparison was insignificant for grade 3 dermatitis in either group. Additionally, when considering body mass index (BMI) as a confounding variable and adjusting for its effect, the results revealed that the intervention group developed grade 1 dermatitis significantly later than the placebo group (P &lt; 0.001).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Discussion and conclusion: &lt;/strong&gt;Chicory root extract gel offers an effective, low-risk option for managing radiodermatitis in breast cancer patients. This aligns with the goals of supportive cancer care, which emphasize minimizing side effects, maintaining treatment efficacy, and improving the patient's quality of life.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Trial registration: &lt;/strong&gt;The study was registered in the Clinical Trials Center of Iran ( https://irct.behdasht.gov.ir ) with the number cod: IRCT202206010550","PeriodicalId":22046,"journal":{"name":"Supportive Care in Cancer","volume":"32 12","pages":"805"},"PeriodicalIF":2.8,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142669244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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