Supportive Care in Cancer最新文献

{"title":"Efficacy of compression therapy for prevention of peripheral neuropathy caused by taxane-based chemotherapy: a single-center retrospective observational study.","authors":"Yuko Kanbayashi, Takeshi Ishikawa, Yusuke Tabuchi, Kazuko Sugatani, Tetsuya Taguchi, Koichi Takayama","doi":"10.1007/s00520-025-09527-1","DOIUrl":"https://doi.org/10.1007/s00520-025-09527-1","url":null,"abstract":"<p><strong>Introduction: </strong>Chemotherapy-induced peripheral neuropathy (CIPN) is a significant complication of taxane-based chemotherapies that limits their clinical utility. This study evaluated the effectiveness of compression therapy using surgical gloves in preventing CIPN in various cancer types, including, but not limited to, breast cancer.</p><p><strong>Patients and methods: </strong>Data from 603 patients who underwent taxane-based chemotherapy at a single institution between April 2018 and January 2024 were retrospectively analyzed. Variables associated with CIPN development were extracted and analyzed using uni- and multivariate ordered logistic regression models.</p><p><strong>Result: </strong>Compression therapy was significantly associated with a reduced incidence of CIPN. Significant predictors of CIPN included lung cancer (odds ratio [OR] = 0.342, P = 0.003), number of chemotherapy cycles (OR = 1.015, P = 0.033), and use of surgical gloves (OR = 0.559, P = 0.003).</p><p><strong>Conclusion: </strong>Compression therapy using simple, cost-effective surgical gloves appeared effective for preventing CIPN in a diverse cancer population undergoing taxane-based chemotherapy. The risk of CIPN increases with the number of chemotherapy cycles, and a lower incidence was observed among patients with lung cancer. These findings provide a foundation for future research aimed at improving patient quality of life during taxane-based chemotherapy.</p>","PeriodicalId":22046,"journal":{"name":"Supportive Care in Cancer","volume":"33 6","pages":"478"},"PeriodicalIF":2.8,"publicationDate":"2025-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144086741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to: Exploring the impact of breast cancer support groups on survivorship and treatment decision‑making in Eastern Ethiopia: a qualitative study.","authors":"Nahom G Belete, Meera Bhakta, Tara Wilfong, Mahlet Shewangizaw, Edilawit Abebaw Abera, Yehenaw Tenaw, Michael Shawel, Habtamu Seife, Biruk Habtamu, Nahom Wondwossen, Elizabeth A Wood","doi":"10.1007/s00520-025-09538-y","DOIUrl":"https://doi.org/10.1007/s00520-025-09538-y","url":null,"abstract":"","PeriodicalId":22046,"journal":{"name":"Supportive Care in Cancer","volume":"33 6","pages":"477"},"PeriodicalIF":2.8,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144080763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sleep quality trajectories and their relationship with quality of life in patients with hepatocellular carcinoma: a prospective cohort study.","authors":"Fan-Rong Li, Rong-Rui Huo, Feng-Juan Zhao, Jian-Hong Zhong, Xue-Mei You","doi":"10.1007/s00520-025-09518-2","DOIUrl":"https://doi.org/10.1007/s00520-025-09518-2","url":null,"abstract":"<p><strong>Purpose: </strong>To identify the classes of sleep quality trajectories in patients with hepatocellular carcinoma (HCC) and analyze differences in patient characteristics across these classes and to explore the relationship between sleep quality trajectory and quality of life (QOL) in patients.</p><p><strong>Methods: </strong>A total of 205 patients completed sleep quality assessments at four time points (before surgery and 1, 3, and 6 months after surgery). Classes of heterogeneous sleep quality trajectories were identified using a latent class mixed-effects model. The differences in the characteristics of patients across classes were identified by unordered multicategorical logistic regression. The relationship between sleep quality trajectory and QOL was assessed using a generalized estimation equation model.</p><p><strong>Results: </strong>Three latent classes of sleep quality trajectories were identified in HCC patients: persistent good sleep (19.5%); persistent poor sleep (75.6%); and worsening (4.9%). Depression, fatigue, comorbidities, and drinking were associated with an increased odds of belonging to the persistent poor sleep class compared to the persistent good sleep class. Tumor size ≥ 5 cm and comorbidities were associated with an increased odds of belonging to the worsening class. The decreases in QOL from admission to 1, 3, and 6 months after surgery were significantly higher for patients in the worsening class compared to patients in the persistent good sleep class (all P < 0.001).</p><p><strong>Conclusion: </strong>The sleep quality trajectories in patients with HCC were characterized by three latent classes; patients in these classes differed in disease characteristics, psychological, and physical symptoms. Sleep quality worsening can lead to significant declines in the QOL of patients after surgery.</p>","PeriodicalId":22046,"journal":{"name":"Supportive Care in Cancer","volume":"33 6","pages":"476"},"PeriodicalIF":2.8,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144079736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Improving our understanding of the quality of life of patients with metastatic or recurrent/persistent anal cancer: a systematic review.","authors":"Samantha C Sodergren, Rowan Edwards, Rahul Krishnatry, Marianne G Guren, Kristopher Dennis, Pierfrancesco Franco, Francesca de Felice, Anne-Sophie Darlington, Vassilios Vassiliou","doi":"10.1007/s00520-025-09520-8","DOIUrl":"10.1007/s00520-025-09520-8","url":null,"abstract":"<p><strong>Purpose: </strong>Chemoradiation (CRT) is used to treat anal carcinomas which, for most patients with loco-regional disease, results in a cure but is associated with acute and chronic complications impairing quality of life (QoL). Patients with metastatic disease or recurrence are likely to experience additional QoL concerns. This paper identifies the QoL issues of these patients and determines whether the EORTC QLQ-ANL27 (QLQ-ANL27), a measure of QoL of patients treated with CRT for anal cancer used alongside the core EORTC QLQ-C30 (QLQ-C30), is suitable or needs adapting.</p><p><strong>Methods: </strong>A systematic review was conducted of studies published between 2014 and 2024 reporting QoL of patients with metastatic or recurrent/persistent anal cancer or follow-up data of patients treated with CRT for anal cancer.</p><p><strong>Results: </strong>This review included 23 papers, only three focused exclusively on metastatic and/or recurrent anal cancer. Most of the 53 reported symptoms related to bowel, urinary, and sexual functioning, with 60% covered by the QLQ-ANL27 or the QLQ-C30. Issues not captured include, for example, neuropathy, hair loss, musculoskeletal problems, urinary incontinence, and embarrassment.</p><p><strong>Conclusion: </strong>There is a paucity of research looking specifically at QoL outcomes of patients with metastatic or recurrent anal cancer. Whilst the QLQ-ANL27 captures most QoL issues affecting these patients, it might require adapting to improve its sensitivity.</p>","PeriodicalId":22046,"journal":{"name":"Supportive Care in Cancer","volume":"33 6","pages":"475"},"PeriodicalIF":2.8,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12081495/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144080765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dissemination planning in exercise oncology trials-a systematic review of trial protocols.","authors":"Emily Smyth, Lydia Politi, Emer Guinan, David Mockler, Linda O'Neill","doi":"10.1007/s00520-025-09532-4","DOIUrl":"https://doi.org/10.1007/s00520-025-09532-4","url":null,"abstract":"<p><strong>Purpose: </strong>The paucity of exercise rehabilitation services for cancer survivors indicates a research-to-practice gap. Dissemination and Implementation research addresses this gap by focusing on the adoption, implementation, and sustainability of evidence-based interventions. Dissemination, the active process of sharing research findings, is critical to the implementation of evidence-based practice. This systematic review examined adherence of exercise oncology trial protocols to the SPIRIT 2013 checklist items pertaining to dissemination planning, items 31a, 31b, and 31c, which address how dissemination is planned, authorship eligibility is considered, and what plans are in place to share data and the protocol.</p><p><strong>Methods: </strong>A systematic review was conducted following the PRISMA guidelines. EMBASE, MEDLINE, CINAHL, Web of Science-Core Collection, Google Scholar, and the Central Trial Registry via Cochrane were searched (16/05/2024). Title and abstract screening, full-text review, and data extraction were completed in duplicate.</p><p><strong>Results: </strong>Eighty-six trial protocols were included, thirty-one (36.1%) did not report dissemination plans. Item 31 was reported as follows (n = number of trials, frequency (%)); 31a plans to communicate trial results to: participants (n = 19, 22.1%), healthcare professionals (n = 43, 50%), the public (n = 25, 29.2%), and other relevant groups (n = 22, 25.6%), 31b: author eligibility (n = 3, 3.5%) and plans regarding use of professional writers (n = 4, 4.7%), and 31c plans for granting access to participant level dataset (n = 28, 32.6%), full protocol (n = 1, 1.2%) and statistical code (n = 1, 1.2%). Peer-reviewed journal (n = 41, 47.67%) and conferences/professional meetings (n = 38, 44.2%) were the most frequently reported planned dissemination strategies.</p><p><strong>Conclusion: </strong>Reporting of the SPIRIT 2013 checklist Item 31 is generally low in exercise oncology trial protocols. Greater consideration of dissemination planning is required to support the implementation of exercise oncology research into practice.</p><p><strong>Registration: </strong>https://doi.org/10.17605/OSF.IO/M8HFP.</p>","PeriodicalId":22046,"journal":{"name":"Supportive Care in Cancer","volume":"33 6","pages":"473"},"PeriodicalIF":2.8,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12078369/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144080764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The experience and needs of self-care in elderly colorectal cancer stoma patients: a qualitative study.","authors":"Yan Xue, Kaili Lv, Chenye Yuan, Guidi Fan, Ping Yu","doi":"10.1007/s00520-025-09530-6","DOIUrl":"https://doi.org/10.1007/s00520-025-09530-6","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to describe the real experiences and needs of stoma self-care in elderly colorectal cancer patients, providing a theoretical basis for healthcare professionals to develop effective intervention measures.</p><p><strong>Methods: </strong>Semi-structured, in-depth interviews were conducted with the thirteen elderly colorectal cancer patients with stomas. These interviews were audio-recorded and transcribed verbatim. The interview data were then organized, analyzed, and thematically refined using Colaizzi's 7-step analysis method.</p><p><strong>Results: </strong>This study extracted three overarching themes and seven corresponding sub-themes. Theme one, actively seeking help, encompassed pre-rehabilitation needs, social support needs, and continuity of care needs. Theme two, new challenges posed by stomas, included sub-themes related to changes in daily life and psychological burdens. Theme three, courageous acceptance and proactive coping, comprised cognitive changes and behavioral changes as its sub-themes.</p><p><strong>Conclusion: </strong>The study's findings suggest that inadequate in-hospital stoma care education and a lack of continuity of care at home can result in heightened challenges for elderly patients. Healthcare professionals should implement a personalized, full-process education program tailored to geriatric patients' specific needs, ensuring seamless care transition and coordinated management between hospital and home environments.</p>","PeriodicalId":22046,"journal":{"name":"Supportive Care in Cancer","volume":"33 6","pages":"474"},"PeriodicalIF":2.8,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144079808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the usefulness of protocol-based magnesium supplementation for hypomagnesemia in patients with advanced or recurrent colorectal cancer treated with panitumumab.","authors":"Daisuke Ito, Hiroki Asano, Michio Kimura, Eiseki Usami","doi":"10.1007/s00520-025-09531-5","DOIUrl":"https://doi.org/10.1007/s00520-025-09531-5","url":null,"abstract":"<p><strong>Purpose: </strong>Panitumumab (Pmab) is associated with a higher incidence and severity of hypomagnesemia compared to cetuximab, necessitating appropriate monitoring and management strategies. This study aimed to evaluate the efficacy of protocol-based magnesium (Mg) supplementation for treating hypomagnesemia in patients with advanced or recurrent colorectal cancer receiving Pmab.</p><p><strong>Methods: </strong>In this retrospective study, patients with colorectal cancer treated with Pmab between October 2010 and September 2023 were divided into two groups: the pre-protocol group (n = 30) and the post-protocol group (n = 30). The incidence of hypomagnesemia was compared between the groups. The hypomagnesemia management protocol included Mg supplementation at grade 1 (< LLN-1.2 mg/dL), initially with 20 mL (1 mEq/mL) of Mg sulfate injection. If Mg levels continued to decrease despite supplementation, the dose was increased to 40 mL (1 mEq/mL).</p><p><strong>Results: </strong>No significant difference was observed in the frequency of hypomagnesemia between the pre-protocol (56.7%, 17/30) and post-protocol (53.3%, 16/30) groups (P = 1.000). However, the incidence of grade 3 or higher hypomagnesemia was significantly lower in the post-protocol group than in the pre-protocol group (3.3%, 1/30 vs. 30.0%, 9/30; P = 0.012). The rate of deterioration from grade 1 to grade 3 or higher in patients who received Mg supplementation was significantly lower in the post-protocol group than in the pre-protocol group (6.3%, 1/16 vs. 60.0%, 9/15; P = 0.002).</p><p><strong>Conclusion: </strong>Early Mg supplementation effectively reduced the incidence of severe hypomagnesemia, highlighting the utility of this protocol in managing hypomagnesemia in Pmab-treated patients.</p>","PeriodicalId":22046,"journal":{"name":"Supportive Care in Cancer","volume":"33 6","pages":"472"},"PeriodicalIF":2.8,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144047121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quality of life and appraisal factors of patients with advanced cancer and their family caregivers.","authors":"Jia Liu, Yuexia Zhang, Ting Guan, Xiaomeng Wang, Chunxuan Ma, Laurel Northouse, Lixin Song","doi":"10.1007/s00520-025-09512-8","DOIUrl":"10.1007/s00520-025-09512-8","url":null,"abstract":"<p><strong>Purpose: </strong>Few existing interventions have effectively improved the quality of life (QOL) for patients with advanced cancer and their caregivers, partly due to limited research on the factors associated with QOL. Guided by an adapted stress-coping model, this study aimed to examine the associations between the QOL of cancer patients and their caregivers and their primary and secondary appraisals. Primary appraisals involve perceptions and evaluations of advanced cancer and related caregiving, while secondary appraisals relate to their available resources and coping capabilities.</p><p><strong>Methods: </strong>Using multi-level modeling, we conducted a secondary analysis of the baseline data collected from a randomized clinical trial that examined the effects of a family-based, psychoeducational support program for patients with advanced cancer and their caregivers (N = 362 dyads).</p><p><strong>Results: </strong>The appraisal variables hypothesized in the adapted stress-coping model explained 74.14% of the variance in the QOL of patients with advanced cancer and their caregivers when controlling for demographics and other disease-related variables. Better QOL in patients and caregivers was associated with less negative appraisals of illness/caregiving, less uncertainty and hopelessness, less avoidant coping strategies, more family support, more health behaviors, higher self-efficacy, and more active coping strategies.</p><p><strong>Conclusion: </strong>Our study highlights the significant impact that advanced cancer has on patients and their caregivers' perceptions, responses to the illness, and QOL. Future interventions may benefit from addressing illness/caregiving appraisals, uncertainty, hopelessness, family support, health behaviors, self-efficacy, and coping strategies. However, further research is needed to determine the effectiveness of interventions specifically targeting these factors.</p>","PeriodicalId":22046,"journal":{"name":"Supportive Care in Cancer","volume":"33 6","pages":"471"},"PeriodicalIF":2.8,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12078350/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144062257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The experience of subjective financial distress on cancer patients in China: A qualitative study.","authors":"Tianying Yao, Linglong Liu, Xiaoxuan Li, Mingxia Chen, Lihua Lu","doi":"10.1007/s00520-025-09498-3","DOIUrl":"https://doi.org/10.1007/s00520-025-09498-3","url":null,"abstract":"<p><strong>Purpose: </strong>To explore the experience of Chinese cancer patients with SFD (Subjective Financial Distress), and add new evidence to studies on the SFD of cancer.</p><p><strong>Methods: </strong>Cancer patients and caregivers hospitalized in the oncology department of a Grade A hospital in Jiangsu Province from August 2022 to October 2022 were recruited as participants for semi-structured interviews using purposeful sampling and the maximum variation principle. The themes were extracted using Colaizzi's phenomenological data analysis method.</p><p><strong>Results: </strong>The interview involved 24 participants who qualified, comprising 15 patients and 9 caregivers. A total of 3 themes and 9 sub-themes were extracted from interviews: (1) financial risk perception (increasing objective financial burden, decreasing financial accessibility); (2) coping behaviors (changes in daily consumption patterns, changes in work status, changes in treatment plans, and seeking support); (3) negative psychological response (personal dimension, family dimension, and social dimension).</p><p><strong>Conclusion: </strong>SFD is widely present in Chinese cancer families and is being dealt with passively, which adversely affects the lives or work of cancer families. Healthcare professionals should pay attention to this phenomenon and conduct early and comprehensive assessments so that future interventions can be implemented to alleviate their SFD.</p>","PeriodicalId":22046,"journal":{"name":"Supportive Care in Cancer","volume":"33 6","pages":"470"},"PeriodicalIF":2.8,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144049759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of renal function on non-hematologic toxicities in mCRC patients treated with TAS-102: a post-hoc analysis of the JASCC-CINV2001 study.","authors":"Hironori Fujii, Masami Tsuchiya, Daichi Watanabe, Miki Chin, Daisuke Hirate, Katsuyuki Takahashi, Makiko Go, Toshihiro Kudo, Kazuhiro Shimomura, Yosuke Ando, Shinya Tani, Takao Takahashi, Katsuhisa Hayashi, Hironobu Hashimoto, Naomi Matsunami, Masaya Takahashi, Akiko Hasegawa, Takashi Uchida, Akiko Kubo, Nobuhisa Matsuhashi, Akio Suzuki, Junichi Nishimura, Naoki Inui, Hirotoshi Iihara","doi":"10.1007/s00520-025-09504-8","DOIUrl":"https://doi.org/10.1007/s00520-025-09504-8","url":null,"abstract":"<p><strong>Purpose: </strong>Although the efficacy of trifluridine/tipiracil hydrochloride (TAS-102) in treating metastatic colorectal cancer (mCRC) is well established, its non-hematologic toxicities in relation to renal function remain unclear. This study aimed to assess the impact of creatinine clearance (Ccr) on non-hematologic toxicities, including nausea and vomiting, in patients with mCRC treated with TAS-102.</p><p><strong>Methods: </strong>This study was conducted as a post-hoc analysis of the JASCC-CINV2001 study, a multicenter observational study of mCRC patients. Using a Cox proportional hazards model, we assessed the relationship between Ccr and nausea or vomiting, and used a generalized estimating equations (GEE) logistic regression model to analyze the association between Ccr and additional toxicities, including fatigue, constipation, diarrhea, insomnia, and dysgeusia. Toxicities were evaluated at weekly intervals over four weeks.</p><p><strong>Results: </strong>Among 100 patients, median Ccr was 80.5 ml/min. The primary analysis showed no significant association between Ccr and nausea or vomiting. However, the secondary analysis revealed a significant link between lower Ccr and the incidence of diarrhea (P = 0.02).</p><p><strong>Conclusion: </strong>These results suggest that although TAS-102-induced nausea and vomiting are not strongly influenced by renal function, decreased renal function increases the risk of diarrhea. Enhanced antiemetic measures may not be necessary for TAS-102 patients with impaired renal function, but monitoring for diarrhea is recommended.</p>","PeriodicalId":22046,"journal":{"name":"Supportive Care in Cancer","volume":"33 6","pages":"469"},"PeriodicalIF":2.8,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144054651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}