Supportive Care in Cancer最新文献

{"title":"Comment on \"Exploring associations between area deprivation index, income, and loneliness among cancer caregivers\".","authors":"Sangameshwar Manikya, Varshini Vadhithala, Rajnish Kumar, Pankaj Nainwal","doi":"10.1007/s00520-026-10755-2","DOIUrl":"https://doi.org/10.1007/s00520-026-10755-2","url":null,"abstract":"","PeriodicalId":22046,"journal":{"name":"Supportive Care in Cancer","volume":"34 6","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147857220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Current non-pharmacological practices for cancer-related fatigue in oncology rehabilitation: results of a national provider survey.","authors":"Shana E Harrington, Jeannette Q Lee, Anne B Fleischer, Kelley C Wood, Joy C Cohn, Daniel J Malone, Mary Insana Fisher","doi":"10.1007/s00520-026-10717-8","DOIUrl":"https://doi.org/10.1007/s00520-026-10717-8","url":null,"abstract":"<p><strong>Purpose: </strong>Cancer-related fatigue (CRF) is one of the most common side effects of cancer treatment, yet there is little consensus on best non-pharmacologic practices to manage this debilitating side effect. The purpose of this study was to describe current non-pharmacologic practice patterns for managing CRF and barriers to rehabilitation.</p><p><strong>Methods: </strong>An electronic survey, developed by the authors using the CHERRIES checklist, was piloted via REDCap™ by nine participants. Data collected included demographics, clinical experience, frequency (none of the time, some of the time, and all of the time) of 15 common non-pharmacologic CRF interventions derived by expert consensus, effectiveness of interventions, and barriers to care for CRF. The survey took approximately 7 min to complete and was distributed via emails or flyers to cancer support groups, listservs, recruitment flyers, and word of mouth. All analyses were descriptive, including frequencies and percentages, and were performed using Microsoft Excel.</p><p><strong>Results: </strong>One hundred ninety-seven rehabilitation providers completed the survey: physical therapy (60%), occupational therapy (20%), speech-language pathology (9%), and exercise physiology (5%). All disciplines indicated frequently applying more than one of the following within their CRF interventions: therapeutic activities (78%), aerobic/strengthening/flexibility exercise (73.1%), energy conservation strategies (57.4%), and self-management education (48.2%). All professions measured the effectiveness of their fatigue interventions using patients' subjective reports (e.g., fatigue severity). Barriers to receiving care were \"appointment fatigue\" and financial constraints.</p><p><strong>Conclusions: </strong>When developing CRF clinical practice guidelines, current rehabilitation practice patterns and survivors' barriers to care should be considered along with the highest level of evidence-based interventions.</p>","PeriodicalId":22046,"journal":{"name":"Supportive Care in Cancer","volume":"34 6","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147843050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sensorineural hearing loss after pediatric cranial radiotherapy: a multicenter analysis of dosimetric and clinical risk factors.","authors":"William Gehin, Luc Ollivier, Emmanuel Jouglar, Claire Dossun, Maria Jolnerovski, Valérie Bernier-Chastagner","doi":"10.1007/s00520-026-10769-w","DOIUrl":"https://doi.org/10.1007/s00520-026-10769-w","url":null,"abstract":"<p><strong>Background: </strong>No multicenter study has validated cochlear dose constraints for hearing preservation in pediatric brain tumor patients in a real-world setting. Although the PENTEC review proposed a 35 Gy mean cochlear dose threshold, supporting evidence from heterogeneous, multicenter pediatric cohorts remains scarce.</p><p><strong>Purpose: </strong>To evaluate dosimetric, therapeutic, and clinical risk factors for sensorineural hearing loss (SNHL) after pediatric cranial radiotherapy in a national multicenter cohort, with a specific focus on validating the clinical relevance of the 35 Gy mean cochlear dose threshold.</p><p><strong>Methods: </strong>We retrospectively analyzed 88 children treated with cranial radiotherapy between 2014 and 2024 across four French pediatric radiotherapy centers participating in the national PediaRT registry. All patients had baseline and at least two post-radiotherapy audiograms graded according to the Chang Ototoxicity Scale, with SNHL defined as Chang grade ≥ 1a. Mean (Dmean) and minimum (Dmin) cochlear doses were extracted and analyzed using Kaplan-Meier estimates and Cox proportional hazards models.</p><p><strong>Results: </strong>Over a median follow-up of 37 months, 17 patients (19.3%) developed SNHL. In multivariate analysis, both a mean cochlear dose ≥ 35 Gy (HR = 3.90; 95% CI: 1.24-12.23; p = 0.020) and cisplatin exposure (HR = 3.85; 95% CI: 1.40-10.64; p = 0.009) were independently associated with SNHL. The 5-year cumulative incidence of SNHL was 43.4% for Dmean ≥ 35 Gy versus 13.1% for < 35 Gy (p = 0.0014), and 51.6% with cisplatin versus 12.4% without (p < 0.001). A significant monotonic relationship between cochlear dose and SNHL severity was observed (p = 0.0011).</p><p><strong>Conclusion: </strong>This study provides the first national, multicenter validation of the 35 Gy mean cochlear dose threshold in a real-world pediatric population and identifies cisplatin exposure as a major independent risk factor. These findings support strict cochlear dose minimization during treatment planning and systematic long-term audiological surveillance in pediatric cancer survivorship care.</p>","PeriodicalId":22046,"journal":{"name":"Supportive Care in Cancer","volume":"34 6","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147857310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A systematic review of the assessment model for palliative care needs in cancer patients.","authors":"Chunjian Xu, Yifei Xie, Ying Li, Shibo Guan, Tingting Cai, Lijuan Song","doi":"10.1007/s00520-026-10749-0","DOIUrl":"https://doi.org/10.1007/s00520-026-10749-0","url":null,"abstract":"<p><strong>Background: </strong>Timely palliative care can reduce the disease burden and improve quality of life in patients with cancer. Although several studies have developed assessment models for palliative care needs in cancer patients, the quality and clinical applicability of these models remain unclear.</p><p><strong>Objective: </strong>To systematically review existing assessment models for palliative care needs in patients with cancer, with a focus on their characteristics, predictors, risk of bias, and applicability.</p><p><strong>Methods: </strong>A systematic search was conducted in PubMed, Cochrane Library, Embase, Web of Science, CINAHL, Scopus, China National Knowledge Infrastructure (CNKI) through September 12, 2025. Data extraction and evaluation were rigorously performed by two researchers based on the Prediction Model Risk of Bias Assessment Tool (PROBAST).</p><p><strong>Results: </strong>A total of 5714 articles were identified, and eight studies were included, which covered 24 models for assessing palliative care needs. The sample size of the included studies ranged from 179 to 54,628, with areas under the curve ranging from 0.724 to 0.998. The models in all the included studies encompassed four categories of predictive factors: general demographic data, symptom/functional assessments, laboratory indicators, and treatment status. Five studies were rated as having a high risk of bias, primarily due to high risks associated with participants and conclusions, with generally low applicability.</p><p><strong>Conclusion: </strong>Existing models demonstrate potential for identifying patients with cancer who have increased palliative care needs using routinely collected clinical data. Commonly included predictors were symptom burden, functional status, laboratory parameters, treatment-related factors, and demographic characteristics. However, the overall body of evidence is constrained by a substantial risk of bias, particularly arising from inappropriate data sources, limited sample sizes, suboptimal handling of continuous variables, insufficient reporting of missing data, and the lack of robust internal or external validation. In addition, many models adopted mortality-based surrogate outcomes rather than clinically meaningful indicators of palliative care needs. Therefore, the currently available models should be interpreted with caution, and further high-quality model development and external validation are required before they can support broader routine clinical implementation. Future research should prioritize clinically actionable outcomes and incorporate patient-, caregiver-, and family-level factors to improve the relevance of these models for referral decisions and care planning.</p>","PeriodicalId":22046,"journal":{"name":"Supportive Care in Cancer","volume":"34 6","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147857252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Burnout, stress, and resilience in pediatric onco-hematology rehabilitation: results from the multicenter Rehabilitation Burnout Study (REBURN).","authors":"Giulia Zucchetti, Francesca Rossi, Elisa Marconi, Monica Valle, Chiara Battaglini, Federica Nota, Riccardo Casalaz, Paolo Colavero, Maria Montanaro, Federica Maio, Cinzia Favara Scacco, Mario Cardano, Alessandro Gennaro, Dorella Scarponi, Paola Quarello, Johanna M C Blom, Franca Fagioli","doi":"10.1007/s00520-026-10692-0","DOIUrl":"https://doi.org/10.1007/s00520-026-10692-0","url":null,"abstract":"<p><strong>Background: </strong>Rehabilitation professionals in pediatric onco-hematology face intense emotional and relational demands that heighten vulnerability to burnout. Despite their key role in children's recovery, this group remains underrepresented in psycho-oncology research.</p><p><strong>Objective: </strong>To assess burnout, compassion satisfaction, compassion fatigue, perceived stress, and resilience among rehabilitation professionals in Italian pediatric onco-hematology centers and to explore the organizational meanings underpinning their experiences.</p><p><strong>Methods: </strong>A mixed-methods multicenter study was conducted across eleven centers in the AIEOP network. Thirty professionals completed validated scales (ProQOL-5, Maslach Burnout Inventory, Perceived Stress Scale, Resilience Scale for Adults). Semi-structured interviews were analyzed using Automated Co-occurrence Analysis for Semantic Mapping (ACASM).</p><p><strong>Results: </strong>Participants reported high compassion satisfaction and moderate burnout, with 66.7% scoring high on depersonalization. Compassion fatigue correlated positively with emotional exhaustion (ρ = 0.45, p = 0.013) and perceived stress (ρ = 0.36, p = 0.048). Resilience did not correlate significantly with distress measures. ACASM identified two semantic dimensions-Relationship-Intervention and Users-Institution-indicating that emotional strain stems largely from institutional and relational dynamics rather than patient contact.</p><p><strong>Conclusions: </strong>Rehabilitation professionals experience a complex balance of meaning and fatigue. Organizational support, structured supervision, and participatory dialogue with management are crucial to sustain well-being and preserve care quality.</p>","PeriodicalId":22046,"journal":{"name":"Supportive Care in Cancer","volume":"34 6","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147843111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Noddings' caring theory-based intervention to enhance coping with death competence in advanced lung cancer patients: a randomized controlled trial.","authors":"Jing Li, Runqin Huang, Xian Luo, YongJia Zhan, Chao Yan, Shenghuan Yang, Xiaojing Tian, Guoping He, Yonghong Li","doi":"10.1007/s00520-026-10739-2","DOIUrl":"https://doi.org/10.1007/s00520-026-10739-2","url":null,"abstract":"<p><strong>Purpose: </strong>This randomized controlled trial aimed to evaluate the effects of a Noddings' caring theory-based intervention on coping with death competence (CDC), death attitudes, and psychological distress in patients with advanced lung cancer.</p><p><strong>Methods: </strong>Seventy inpatients were randomly allocated to the intervention group (n = 35) or the control group (n = 35). The 3-week intervention comprised modeling, dialogue, practice, and recognition phases. Outcomes, including CDC, attitude toward death, anxiety, and depression, were assessed at baseline (T0), post-intervention (T1), and 1-month follow-up (T2).</p><p><strong>Results: </strong>No significant between-group differences were observed at baseline. Following the intervention, patients in the intervention group demonstrated significantly higher CDC total and subscale scores, more positive death attitudes, and lower anxiety and depression scores than those in the control group at both post-intervention and 1-month follow-up.</p><p><strong>Conclusion: </strong>The Noddings-based program effectively enhanced death-coping competence, improved death attitudes, and reduced psychological distress in patients with advanced lung cancer.</p><p><strong>Trial registration: </strong>ChiCTR2600118530, 2/6/2026 retrospectively registered.</p>","PeriodicalId":22046,"journal":{"name":"Supportive Care in Cancer","volume":"34 6","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147842956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cooling the language on cryotherapy as an effective intervention to prevent or mitigate chemotherapy-induced peripheral neuropathy.","authors":"Michael Daniel, Erin Hornsby, Jodelle Carlee, Jennifer Kreider, Ellen Mary Lavoie Smith","doi":"10.1007/s00520-026-10742-7","DOIUrl":"https://doi.org/10.1007/s00520-026-10742-7","url":null,"abstract":"","PeriodicalId":22046,"journal":{"name":"Supportive Care in Cancer","volume":"34 6","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147843088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Night-time compression with a Mobiderm® auto-adjustable arm-sleeve in addition to daytime compression was superior to daytime compression alone for maintenance therapy of upper limb lymphedema in breast cancer patients in a randomized controlled trial: LYMphoNIGHT study.","authors":"Pinar Borman, Sandrine Mestre, Burcu Duyur Cakit, Pascal Giordana, Busem Atar, Eve Vernhet, Sophie Blaise, Isabelle Quéré","doi":"10.1007/s00520-026-10735-6","DOIUrl":"10.1007/s00520-026-10735-6","url":null,"abstract":"<p><strong>Purpose: </strong>To assess the benefit of night-time compression in addition to daytime compression on arm excess volume after 3 months of maintenance treatment in patients with secondary upper limb breast cancer-related lymphedema (BCRL).</p><p><strong>Methods: </strong>This multicenter, controlled, randomized study was carried out in six centers in France and Turkey. Women with upper limb BCRL who had undergone the intensive phase of decongestive lymphedema therapy (DLT) were randomized into two groups: the Control group wore a daytime compression sleeve without any night compression for 3 months and the MOBIDERM Autofit (MobA) group used a night-time compression sleeve in addition to the daytime compression. The primary outcome was the change in arm excess volume between day 0 (D0) and D90. The main secondary endpoints were: quality of life (QoL), sleep quality, skin thickness and suppleness, satisfaction, compliance, and safety.</p><p><strong>Results: </strong>Fifty-six patients were recruited (mean (± SD) age: 61.4 ± 12.3 years). Between D0 and D90, the mean excess volume decreased by 29.2% in the MobA group and increased by 10.7% in the Control group (p = 0.001). Only 3.6% of patients in the MobA group presented with treatment failure vs. 23.1% in the Control group. At D90, patients in the MobA group had a significantly greater improvement in QoL (p < 0.05), sleep quality (p = 0.018), skin suppleness (p = 0.01) reduced skin thickness (p = 0.025) compared with the Control group.</p><p><strong>Conclusion: </strong>MOBIDERM Autofit used in addition to daytime compression for 3 months during the maintenance phase after DLT was superior to daytime compression alone for the reduction of arm excess volume. Registered on ClinicalTrials.gov (NCT04203069; 17/12/2019).</p>","PeriodicalId":22046,"journal":{"name":"Supportive Care in Cancer","volume":"34 6","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13149725/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147843106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The clinical relevance of sleep disturbance (\"insomnia\") in patients with advanced cancer receiving palliative care: a scoping review.","authors":"Shauna Munir, Eva Jones, Faith Precious Omeokwe, Andrew Neil Davies","doi":"10.1007/s00520-026-10738-3","DOIUrl":"https://doi.org/10.1007/s00520-026-10738-3","url":null,"abstract":"<p><strong>Purpose: </strong>Sleep disturbance (\"insomnia\") is common in patients with advanced cancer receiving specialist palliative care. The aim of this scoping review was to determine the clinical relevance of sleep disturbance in this cohort of patients.</p><p><strong>Methods: </strong>Standard methodology was employed, and four databases were searched from inception (Medline, CINAHL, Embase, and APA PsycInfo). Hand searching of relevant sources was also undertaken. Included studies needed to have a sleep focus, and to utilise a validated sleep assessment tool (and/or objective measure of sleep quality).</p><p><strong>Results: </strong>Sixteen studies met the criteria for inclusion. The studies highlight that sleep disturbance is associated with a range of physical symptoms (e.g. fatigue, drowsiness), a variety of psychological problems (e.g. anxiety, depression), impaired quality of life, and reduced overall survival.</p><p><strong>Conclusion: </strong>Sleep disturbance is an \"orphan\" symptom, and the results of this scoping review suggest that it deserves much greater attention. Indeed, healthcare professionals should screen all palliative care patients for the problem and, when identified, perform a thorough assessment and initiate an appropriate treatment.</p>","PeriodicalId":22046,"journal":{"name":"Supportive Care in Cancer","volume":"34 6","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147842431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patient-reported quality-of-life outcomes in immune checkpoint inhibitor therapy: addressing gaps, capturing patient experience, and advancing the field.","authors":"Zeinab A Mohamed, Charles S Kamen","doi":"10.1007/s00520-026-10744-5","DOIUrl":"https://doi.org/10.1007/s00520-026-10744-5","url":null,"abstract":"<p><strong>Background: </strong>Immune checkpoint inhibitors (ICIs) have transformed cancer care, extending survival across multiple malignancies. Yet quality-of-life (QoL) outcomes remain underreported and inconsistently integrated into research and practice. Standard frameworks and instruments do not fully capture immune-related adverse events (irAEs) and may overlook the experiences of racially, socioeconomically, linguistically, and digitally marginalized groups.</p><p><strong>Purpose: </strong>This review examines how methodological limitations, and systemic inequities constrain the assessment of QoL in immune checkpoint inhibitor (ICI) therapy. It evaluates existing QoL instruments and frameworks guiding patient-reported outcomes (PROs) and identifies opportunities for advancing equity-centered, patient-informed approaches.</p><p><strong>Methods: </strong>This narrative review synthesized evidence identified through literature searches and reference screening across oncology, regulatory science, digital health, equity, and community-engaged research. QoL assessment domains analyzed included methodological rigor, trial design, digital integration, intersectionality, literacy, and social determinants of health.</p><p><strong>Results: </strong>Quality-of-life reporting in ICI trials remains limited, with only about 14% of trials publishing PRO results and fewer than 12% including them in the primary publication. Existing tools inadequately capture irAEs, while trial designs neglect long-term survivorship and diverse populations. Frameworks such as SPIRIT-PRO and CONSORT-PRO improve methodological rigor, but provide limited guidance on equity, cultural adaptation, or caregiver perspectives. Barriers, including digital exclusion, linguistic gaps, and underrepresentation of racial and age groups, further bias QoL evidence.</p><p><strong>Conclusions: </strong>Quality of life should be recognized as a core clinical endpoint and an indicator of equity in ICI therapy evaluation. Future research must integrate culturally validated instruments, inclusive digital strategies, and community-engaged approaches to ensure survivorship outcomes reflect the realities of all patients. By moving beyond survival, QoL assessment can anchor cancer care in equity and patient-centered lived experience.</p>","PeriodicalId":22046,"journal":{"name":"Supportive Care in Cancer","volume":"34 6","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147843130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}