Supportive Care in Cancer最新文献

{"title":"Hematologic immune-related adverse effects of immune checkpoint inhibitors: a review.","authors":"Maria T Cruz Carreras, Francisco González Landrón, Natalie López, Leticia Padrón Alcántara, Dana M Markides, Kathryn J Burk, Patrick Chaftari","doi":"10.1007/s00520-025-09952-2","DOIUrl":"https://doi.org/10.1007/s00520-025-09952-2","url":null,"abstract":"<p><p>Immune checkpoint inhibitors (ICIs) targeting CTLA-4, PD-1, and PD-L1 have transformed cancer therapy but may trigger rare, sometimes fatal hematologic immune-related adverse events (irAEs). The most frequent hematologic irAEs are anemia, thrombocytopenia, and pancytopenia, which occur more often with CTLA-4 inhibitors and in patients receiving combination therapy. Risk is heightened when ICIs are combined with chemotherapy or radiation. Common symptoms include fatigue, abnormal bleeding, easy bruising, and recurrent infections. Diagnosis relies on laboratory studies, histologic evaluation, and review of medication history. Management typically involves ICI discontinuation and immunosuppression with corticosteroids or rituximab; adjunctive options include IVIG, transfusions, or plasmapheresis depending on severity. Research is also exploring cytokines such as IL-2, IL-7, and IL-15 for ICI-related lymphopenia. Current evidence is drawn mainly from case reports and small series, highlighting the need for larger studies to clarify incidence, mechanisms, and optimal management. Recent pharmacovigilance and outcomes data confirm these events remain rare and can present late, underscoring the need for long-term surveillance and robust monitoring systems [Fletcher K and Johnson DB 2024; Durbin SM et al. 2025; Yang Y. et al. 2024; Han X. et al. 2025].</p>","PeriodicalId":22046,"journal":{"name":"Supportive Care in Cancer","volume":"33 10","pages":"912"},"PeriodicalIF":3.0,"publicationDate":"2025-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145239751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identifying gaps and needs in care for adolescents and young adults with melanoma.","authors":"Reece Moore, Nabeel Ahmad, Miriam Kadosh, Ryann Daniels, Clark Andersen, Michael Roth, Kelly Nelson","doi":"10.1007/s00520-025-10001-1","DOIUrl":"https://doi.org/10.1007/s00520-025-10001-1","url":null,"abstract":"<p><strong>Purpose: </strong>Adolescents and young adults (AYAs, age 15-39 years) with melanoma have needs unique from pediatric or adult populations due to interference with developmental milestones. This study aims to assess the needs of AYA melanoma patients using the Needs Assessment and Service Bridge (NA-SB) questionnaire.</p><p><strong>Methods: </strong>A REDCap survey based on the AYA NA-SB was distributed via email, social media, newsletters, and conferences between August to October 2024. Data were reported for the overall population and analyzed by sex, treatment phase, and exposure to immune checkpoint blockers (ICBs).</p><p><strong>Results: </strong>One hundred fifty-two patients participated in the survey. Male and female AYAs had different need profiles, with the males expressing greater need in understanding the role of genetics in diagnosis (51.5% vs. 33.9%, p = 0.019) and the sexual side effects of treatment (38.3% vs. 16.6%, p = 0.016) and the females reporting greater needs in understanding their disease status (71.3% vs. 48.5%, p = 0.003). AYAs on active treatment reported greater needs than those who completed treatment in managing work and life during treatment (55.5% vs. 27.1%, p = 0.03), being equipped to cope with diagnosis (42.8% vs. 25%, p = 0.029), and managing the emotional side effects of treatment (62% vs. 29.5%, p = 0.002). AYAs treated with ICBs had greater needs in managing long-term side effects of treatment (70.8% vs. 31.6%, p = 0.0005), pain management (30.6% vs. 11.6%, p = 0.01), and the physical side effects of treatment (36.7% vs. 16.5%, p = 0.021).</p><p><strong>Conclusion: </strong>AYA melanoma patients express unique needs based on sex, treatment phase, and type of systemic therapy. Assessing patient needs and connecting AYAs to relevant supportive services may help mitigate unique challenges encountered during melanoma treatment and in post-treatment survivorship.</p>","PeriodicalId":22046,"journal":{"name":"Supportive Care in Cancer","volume":"33 10","pages":"913"},"PeriodicalIF":3.0,"publicationDate":"2025-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145245254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Telehealth group session on body image for young breast cancer survivors: a pilot study.","authors":"Krystel A Dieguez, Theresa M Smith, Alicia F Lohmann, Patricia Bowyer","doi":"10.1007/s00520-025-09955-z","DOIUrl":"https://doi.org/10.1007/s00520-025-09955-z","url":null,"abstract":"<p><p>There is a growing concern of how young breast cancer survivors' (BCS) body image is affected secondary to cancer treatment.</p><p><strong>Purposes: </strong>To (1) develop a theory-based telehealth group session to improve body image of young BCS; (2) pilot test the telehealth group session; and (3) measure participant satisfaction with the session.</p><p><strong>Methods: </strong>A telehealth body image group session for BCS was developed based on the cognitive behavioral theory. A case series experimental design was used to determine outcomes of the session.</p><p><strong>Results: </strong>There were three participants. No statistical differences were found in body image across three time points. Participant satisfaction was measured with three questions, where participants were found to be \"mostly satisfied.\"</p><p><strong>Conclusion: </strong>Healthcare providers should be aware that young BCS may have body image concerns. A telehealth group session can be designed and implemented to address body image for young BCS, but sufficient time is needed for participants to incorporate cognitive behavioral techniques into their daily routines.</p>","PeriodicalId":22046,"journal":{"name":"Supportive Care in Cancer","volume":"33 10","pages":"909"},"PeriodicalIF":3.0,"publicationDate":"2025-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145233389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Why tomorrow i will die.","authors":"Sebastiano Mercadante, Alessio Lo Cascio","doi":"10.1007/s00520-025-09984-8","DOIUrl":"https://doi.org/10.1007/s00520-025-09984-8","url":null,"abstract":"","PeriodicalId":22046,"journal":{"name":"Supportive Care in Cancer","volume":"33 10","pages":"910"},"PeriodicalIF":3.0,"publicationDate":"2025-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145233372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors associated with functional independence at hospital discharge and 6 months post-hospitalization in intensive care unit survivors with cancer: A prospective cohort study.","authors":"Gustavo Telles da Silva, Lavinia Gomes Cavalcante, Maria Luiza Valério Dalzini, Leda Tomiko Yamada da Silveira, Débora Stripari Schujmann, Carolina Fu","doi":"10.1007/s00520-025-09978-6","DOIUrl":"https://doi.org/10.1007/s00520-025-09978-6","url":null,"abstract":"<p><strong>Purpose: </strong>Analyze the factors associated with functional independence in cancer patients discharged from the intensive care unit (ICU).</p><p><strong>Methods: </strong>This is a prospective cohort study that included cancer patients discharged from the ICU of a tertiary oncology unit between March 2023 and March 2024. The Barthel Index (BI), Medical Research Council (MRC) score, Handgrip Strength (HS), ICU Mobility Scale (IMS), and 30-s Chair Stand Test (CS-30) were used to evaluate the physical and functional capacity of the patients at 3 times points: ICU discharge, hospital discharge, and 6 months post-hospitalization. Logistic regression was used to identify factors associated with the presence of functional independence at hospital discharge and at 6-month post-hospitalization.</p><p><strong>Results: </strong>In total, 62 patients with a median age of 64 (51-72) years were included. The most common primary tumor site was the digestive system (41.9%) and 6 (9.7%) patients returned to work. Multivariate analysis revealed that higher MRC scores at ICU discharge (OR 1.08; 95% CI 1.01-1.16; p = 0.013) increased the odds of achieving functional independence at hospital discharge and higher IMS scores at hospital discharge (OR 1.41; 95% CI 1.06-1.88; p = 0.017) increased the odds of achieving functional independence at 6 months post-hospitalization.</p><p><strong>Conclusion: </strong>Cancer survivors of critical illness show improvements in physical capacity over time. Muscle strength at ICU discharge and level of mobility at hospital discharge are independent predictors of functional independence at hospital discharge and 6 months post-hospitalization, respectively.</p>","PeriodicalId":22046,"journal":{"name":"Supportive Care in Cancer","volume":"33 10","pages":"911"},"PeriodicalIF":3.0,"publicationDate":"2025-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145233386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Empowering outpatients with breast cancer: The impact of a Continuous Care Program on self-efficacy-a randomized clinical trial.","authors":"Mina Moafi, Sarieh Poortaghi, Violeta Lopez, Marjan Delkhosh, Payam Emami, Shima Haghani, Ramesh Omranipoor","doi":"10.1007/s00520-025-09951-3","DOIUrl":"https://doi.org/10.1007/s00520-025-09951-3","url":null,"abstract":"<p><strong>Background: </strong>Breast cancer is the most prevalent cancer among women globally and a leading cause of cancer-related deaths. Continuous care programs offer ongoing support and education, potentially enhancing self-efficacy in women with breast cancer and consequently improving their quality of life. This study investigated the effect of a continuous care program on the self-efficacy of women with breast cancer in Iran.</p><p><strong>Methods: </strong>A randomized clinical trial was employed involving 76 women aged 20-60 diagnosed with stage two, three, or four breast cancer at the breast clinic of the cancer institute in Imam Khomeini Hospital, Tehran, during September-January 2023. Participants were randomly assigned to either the intervention or control group, each comprising 38 individuals, through random block assignment. The intervention group received a four-session Continuing Care Program (CCP), while the control group received routine care. Data were collected using a researcher-created demographic questionnaire and a breast cancer-specific self-efficacy questionnaire. Data analysis was conducted using SPSS version 20 software.</p><p><strong>Results: </strong>The results of the study indicated a statistically significant difference in self-efficacy post-intervention with higher levels observed in the intervention group compared to the control group (p < .001). The paired t-test results demonstrated a statistically significant increase in the mean self-efficacy scores and all its dimensions post-intervention compared to pre-intervention (p < .001). A statistically significant decrease in self-efficacy related to problem-solving skills was observed in the control group post-intervention compared to pre-intervention (p = .005), and the average self-efficacy score in this group also significantly decreased post-intervention (p = .023).</p><p><strong>Conclusion: </strong>The study found that the CCP is effective in enhancing the self-efficacy of women with breast cancer in Iran. This program can be a beneficial method for improving patients' well-being and delivering appropriate care to this population. The program can be shared with nurses in oncology departments to help them tailor their care plans by understanding the importance of continuity in care planning. Clinical trial registration This research was registered (26/09/2023) in the https://www.irct.ir with registration number (IRCT20230622905861) by the Clinical Trial Registration Center of Iran.</p>","PeriodicalId":22046,"journal":{"name":"Supportive Care in Cancer","volume":"33 10","pages":"908"},"PeriodicalIF":3.0,"publicationDate":"2025-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145233361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bibliometric view on cancer rehabilitation and cancer physiotherapy.","authors":"Melek Nur Berber, Gülay Demir, Hanım Eda Göktaş","doi":"10.1007/s00520-025-09958-w","DOIUrl":"https://doi.org/10.1007/s00520-025-09958-w","url":null,"abstract":"<p><p>Cancer is among the significant immune diseases with a rapidly increasing prevalence worldwide. Cancer rehabilitation and physiotherapy approaches play crucial roles in the treatment process. This bibliometric analysis compiles research on cancer rehabilitation and cancer physiotherapy. The Scopus search engine was preferred for this purpose, and 1769 documents were examined. The data from the relevant search engine were downloaded on October 24, 2023. These data were analysed via the VOSviewer and Biblioshiny programs. While the United States leads in terms of article publications, Canada takes the lead in international collaboration. The most referenced article, with 1197 citations, is \"Early palliative care for patients with advanced cancer: a cluster-randomized controlled trial\" published in \"THE LANCET\" by Zimmeran et al. (2014). The study also identifies the The top three journals with the most citations were \"Supportive Care In Cancer,\" \"Rehabilitation Oncology,\" and \"Pm and R Journal.\" In particular, the University of Southern Denmark stands out as the most involved institution in this field with productive research output. The most prolific author, with 31 articles, is 'Fu Jb.' Among the most frequently used keywords are \"human', 'female', and 'cancer 'rehabilitation'. The findings of this study are valuable not only for researchers and practitioners interested in cancer rehabilitation and physiotherapy but also for anyone seeking insights into practical applications and potential future developments. Ultimately, this research contributes to the ongoing dialogue surrounding the importance of cancer and cancer rehabilitation in the field of immune system disorders and creates a roadmap for future research efforts in this area.</p>","PeriodicalId":22046,"journal":{"name":"Supportive Care in Cancer","volume":"33 10","pages":"906"},"PeriodicalIF":3.0,"publicationDate":"2025-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145225981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on \"Patient-reported pain severity is associated with shorter survival in older adults with newly diagnosed cancer\".","authors":"Prajnasini Satapathy, Rachana Mehta, Ranjana Sah","doi":"10.1007/s00520-025-09974-w","DOIUrl":"https://doi.org/10.1007/s00520-025-09974-w","url":null,"abstract":"","PeriodicalId":22046,"journal":{"name":"Supportive Care in Cancer","volume":"33 10","pages":"903"},"PeriodicalIF":3.0,"publicationDate":"2025-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145226061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Construction of a postoperative home-based pulmonary rehabilitation program protocol for lung cancer patients delivered using the internet: A Delphi-based study.","authors":"Haoyu Zou, Jiani Qu, Yanqing Li, Feilin Wang, Pan Chen, Liuyi Zhang, Honghui Zhang","doi":"10.1007/s00520-025-09916-6","DOIUrl":"10.1007/s00520-025-09916-6","url":null,"abstract":"<p><strong>Objective: </strong>To construct a protocol to guide standardized home-based pulmonary rehabilitation for postoperative lung cancer patients based on the Internet + .</p><p><strong>Methods: </strong>A postoperative home-based pulmonary rehabilitation protocol via the Internet (PHPRPI) for patients with lung cancer was developed through a literature review. The protocol was modified based on the opinions and suggestions of experts in two rounds of expert consultation, utilizing the Delphi method. A three-level, hierarchical structure was employed in the Delphi method, with primary indicators representing broad, overarching concepts, secondary indicators providing more specific details within those concepts, and tertiary indicators offering the most granular and actionable measures. The following coefficients were calculated to assess the robustness of the Delphi method: the positive coefficient was calculated as the percentage of experts completing the questionnaire, with a recommended level of ≥ 70%. The expert authority coefficient (Cr) was calculated as the arithmetic mean of familiarity criteria (Ca) and the degree of familiarity (Cs), with a recommended level of ≥ 0.70. The coefficient of variation (CV) and Kendall's harmony coefficient (ω) were used to indicate the degree of variation and coordination, which range from 0 to 1, with higher values indicating more consistent expert opinions.</p><p><strong>Results: </strong>Eighteen experts completed two rounds of consultation, with the Cr being 0.91, the ω being 0.159 (P < 0.01), and the CV ranging from 0.0477 to 0.1352, indicating good reliability of the Delphi method. The final protocol includes four primary indicators (including composition of the staff, establishment of patient health records, off-line intervention, and online intervention), 14 secondary indicators (e.g., personnel professional, specialized assessment, training frequency, and breathing training methods), and 44 tertiary indicators (e.g., vital sign assessment, content of health education, resistance training, and flexibility training).</p><p><strong>Conclusion: </strong>The PHPRPI provides preliminary evidence to guide postoperative home-based rehabilitation management for lung cancer patients, aiming to improve their health outcomes and well-being. Future randomized controlled trials (RCTs) are needed to further validate the safety and effectiveness of this model and assess whether it is acceptable to patients and healthcare providers.</p>","PeriodicalId":22046,"journal":{"name":"Supportive Care in Cancer","volume":"33 10","pages":"905"},"PeriodicalIF":3.0,"publicationDate":"2025-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12496294/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145226043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identifying opioid misuse in cancer pain: validation of the prescription opioid misuse index in a multicenter study.","authors":"Virginie Guastella, Mélanie Bianchi, Eliane Hanniet, Bruno Pereira, Nicolas Authier","doi":"10.1007/s00520-025-09942-4","DOIUrl":"10.1007/s00520-025-09942-4","url":null,"abstract":"<p><strong>Objectives: </strong>The prevalence of analgesic opioid (AO) misuse among patients with cancer-related chronic pain remains poorly understood, and no screening tool has been validated for this population. The Prescription Opioid Misuse Index (POMI), an eight-item self-administered questionnaire, was developed for chronic non-cancer pain. This study aimed to evaluate the psychometric properties of the POMI in a population of patients with chronic cancer-related pain.</p><p><strong>Methods: </strong>This prospective observational psychometric study was conducted in two oncology day hospitals at the Clermont-Ferrand University Hospital. Eligible patients had active cancer, chronic pain lasting ≥ 3 months and were receiving daily opioid therapy. The POMI questionnaire was completed at inclusion (TEST) and 2 weeks later (RETEST). Psychometric properties were assessed following standard guidelines, including internal consistency, test-retest reliability and external validity using DSM-5 criteria for opioid use disorder as the reference standard.</p><p><strong>Results: </strong>A total of 138 patients were included (58% men), with a mean age of 64 ± 10 years. Internal consistency of the POMI was low (Kuder-Richardson coefficient: 0.22). Test-retest reliability, assessed in 68 patients, showed moderate agreement (Lin's concordance: 0.43 [0.24-0.63]). Correlation between POMI scores and DSM-5 criteria was modest (Spearman's ρ = 0.25). According to the POMI, 11.6% of patients demonstrated opioid misuse versus 17.4% with DSM-5-defined use disorder.</p><p><strong>Conclusions: </strong>The POMI lacks sufficient psychometric validity for use in oncology populations. Future tools should be specifically designed to address the clinical complexity and unique context of chronic cancer-related pain and opioid use.</p>","PeriodicalId":22046,"journal":{"name":"Supportive Care in Cancer","volume":"33 10","pages":"902"},"PeriodicalIF":3.0,"publicationDate":"2025-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12494673/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145226049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}