Supportive Care in Cancer最新文献

{"title":"Exploring online discussions for those living with cutaneous T cell lymphoma: a qualitative study.","authors":"Jenny Jung Sun Park, Michi Shinohara","doi":"10.1007/s00520-025-09945-1","DOIUrl":"https://doi.org/10.1007/s00520-025-09945-1","url":null,"abstract":"<p><strong>Purpose: </strong>Cutaneous T cell lymphoma (CTCL) significantly impacts emotional well-being and quality of life. The role of social media for individuals affected by CTCL has not been thoroughly explored. This study aims to examine the themes and sentiments expressed within a CTCL-specific online support group.</p><p><strong>Methods: </strong>A retrospective qualitative analysis was conducted on posts and comments from a CTCL-specific Facebook group over 1 year (6/14/2022-6/19/2023), collected at 1-week intervals every 28 days. NVivo software was used for inductive coding and thematic analysis, followed by deductive refinement. Content was evaluated for the prevalence of unsupported medical advice, and sentiment analysis was performed using NVivo's Lexalytics Salience Engine.</p><p><strong>Results: </strong>Of 1984 members of the group, 396 engaged in 192 posts and 1736 comments over the study period. Main themes were \"seeking and sharing experiences\" (29%) and \"navigating uncertainty\" (25%), particularly around treatments. The majority (60%) of medical advice shared in the group was unsupported, mainly personal anecdotes and speculations. Negative sentiments were predominant, especially around personal experience and disease progression discussions.</p><p><strong>Conclusion: </strong>The content and predominant themes suggest that this social media group may function as a medium for sharing treatment experiences and discussing emotional or diagnostic uncertainties among those living with CTCL. The predominance of negative sentiment, despite the supportive nature of the group, suggests it may also serve as a platform for emotional release and venting. The emphasis on treatment discussions highlights potential opportunities for developing tailored educational interventions.</p>","PeriodicalId":22046,"journal":{"name":"Supportive Care in Cancer","volume":"33 11","pages":"953"},"PeriodicalIF":3.0,"publicationDate":"2025-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145303654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Step forward: how health insurance mitigates financial toxicity in cancer care in Pakistan.","authors":"Wajiha Ahmad Qazi, Shahid Muhammad Iqbal, QurratulAin Jamil","doi":"10.1007/s00520-025-10004-y","DOIUrl":"https://doi.org/10.1007/s00520-025-10004-y","url":null,"abstract":"<p><strong>Aim: </strong>Cancer imposes a significant financial burden on patients. This study evaluates the role of health cards in reducing financial toxicity (FT) and improving health-related quality of life (HRQOL) and psychological distress among cancer patients in Pakistan.</p><p><strong>Methods: </strong>This cross-sectional study was conducted in Bahawalpur, Pakistan, between March and June 2024. A total of 672 cancer patients (336 with and 336 without health cards) were recruited using non-probability purposive sampling. FT was assessed using the Comprehensive Score for Financial Toxicity (COST), while HRQOL was measured using the Functional Assessment of Cancer Therapy-General (FACT-G). The Depression, Anxiety, and Stress Scale-21 (DASS-21) evaluated psychological distress.</p><p><strong>Results: </strong>Independent t-tests showed significant differences between patients with and without health card coverage: FT significantly decrease from 7.21 to 13.24, HRQOL improve from 28.60 to 47.56, and psychological distress declined, all p < 0.001. FT correlated positively with HRQOL (r = 0.814) and negatively with depression (r = -0.222), anxiety (r = -0.475), and stress (r = -0.675), indicating strong links between financial relief and well-being (p < 0.001). MANOVA results indicated that health cards had a strong multivariate effect across all outcomes (Wilks' Lambda = 0.060, F(5,666) = 2071.97, p < 0.001, η² = 0.940).</p><p><strong>Conclusion: </strong>Health cards play a crucial role in reducing FT while improving HRQOL and psychological well-being among cancer patients in Pakistan. The findings underscore the need to expand health coverage to ensure financial protection and enhance successful treatment outcomes for vulnerable populations.</p>","PeriodicalId":22046,"journal":{"name":"Supportive Care in Cancer","volume":"33 11","pages":"956"},"PeriodicalIF":3.0,"publicationDate":"2025-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145309207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Compression therapy for taxane-induced peripheral neuropathy: promising results undermined by methodological gaps.","authors":"Galip Can Uyar, Enes Yeşilbaş, Kadriye Başkurt","doi":"10.1007/s00520-025-10036-4","DOIUrl":"https://doi.org/10.1007/s00520-025-10036-4","url":null,"abstract":"","PeriodicalId":22046,"journal":{"name":"Supportive Care in Cancer","volume":"33 11","pages":"955"},"PeriodicalIF":3.0,"publicationDate":"2025-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145303665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors associated with medication adherence trajectory among patients treated with oral anticancer drugs: a multicentre cohort study.","authors":"Germain Perrin, Audrey Thomas-Schoemann, François Goldwasser, Pascaline Boudou-Rouquette, Nicolas Delanoy, Claire Gervais, Justine Touchard, Rui Batista, Benoit Blanchet, Jean-Stéphane Giraud, Brigitte Sabatier, Virginie Korb-Savoldelli","doi":"10.1007/s00520-025-09996-4","DOIUrl":"10.1007/s00520-025-09996-4","url":null,"abstract":"<p><strong>Purpose: </strong>Optimal medication adherence to oral systemic anticancer therapies (SACTs) is critical for effective cancer management. However, the factors influencing adherence, particularly in relation to the longitudinal course of the disease, remain poorly understood. This study aimed to identify factors associated with medication adherence trajectories among patients initiating oral SACTs.</p><p><strong>Methods: </strong>A multicentre cohort study was conducted among patients initiating oral SACTs and enrolled in a multidisciplinary risk management programme during day hospitalisation. Medication adherence trajectories were identified using group-based trajectory modelling (GBTM), based on scores from a validated six-item medication adherence questionnaire. Factors associated with trajectory allocation were examined using bias-reduced multinomial logistic regression.</p><p><strong>Results: </strong>A total of 135 participants were included, of whom 71 provided at least two adherence scores for trajectory modelling. Three latent groups of adherence trajectories were identified: (i) continuous optimal adherence (73.2%), (ii) improving adherence (9.9%), and (iii) declining adherence (16.9%). In multivariate analysis, subjects belonging to the declining adherence group were more likely to belong to the low-income category.</p><p><strong>Conclusion: </strong>GBTM identified three distinct and clinically relevant patterns of oral SACT adherence trajectories among outpatients followed during day hospitalisation. Understanding the factors influencing these trajectories provides a dynamic perspective on the complex phenomenon of medication adherence and highlights actionable factors to support tailored health interventions.</p>","PeriodicalId":22046,"journal":{"name":"Supportive Care in Cancer","volume":"33 11","pages":"951"},"PeriodicalIF":3.0,"publicationDate":"2025-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12521283/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145293667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adaptation to colorectal cancer and ostomy: Psychological flexibility mitigates loneliness associated with social withdrawal.","authors":"Guopeng Li, Rui Qin, Xiangyu Zhao, Duan Junyan, Ping Li","doi":"10.1007/s00520-025-10008-8","DOIUrl":"https://doi.org/10.1007/s00520-025-10008-8","url":null,"abstract":"<p><strong>Purpose: </strong>Colorectal cancer (CRC) survivors with permanent stomas may commonly suffer from social withdrawal and subsequently experience loneliness. However, the relationship between social withdrawal and loneliness may vary depending on the individual's psychological flexibility based on Acceptance and Commitment Therapy (ACT) theory. The present study thus examined the association between social withdrawal and loneliness by focusing on the potential moderating roles of psychological flexibility among CRC survivors with permanent stomas.</p><p><strong>Methods: </strong>A cross-sectional sample of 289 CRC survivors with permanent stomas completed the social withdrawal subscales, the stoma acceptance and valuable actions scale, and the 6-item revised UCLA Loneliness scale. Moderation analysis using the PROCESS macro in SPSS was conducted to examine the moderating effects of psychological flexibility and its two components, stoma acceptance and valuable actions.</p><p><strong>Results: </strong>The results indicated that social withdrawal was positively associated with loneliness (r = 0.423, P < 0.001). The moderating analyses showed that psychological flexibility significantly moderated the association of social withdrawal with loneliness (interaction term = - 0.017, P = 0.006). Further exploratory analyses found that the moderating effect of valuable actions was significant (interaction term = - 0.028, P = 0.005), while the stoma acceptance was not.</p><p><strong>Conclusion: </strong>Psychological flexibility, as well as valuable actions, may serve as a protective factor in the potential effects of social withdrawal on loneliness among CRC survivors with permanent stomas.</p>","PeriodicalId":22046,"journal":{"name":"Supportive Care in Cancer","volume":"33 11","pages":"950"},"PeriodicalIF":3.0,"publicationDate":"2025-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145293650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Blautia luti reduces neratinib-induced diarrhea in a rat model.","authors":"Claire P Vieyra, Micaela J Quinn, Emma H Bateman, Hannah R Wardill, Joanne M Bowen","doi":"10.1007/s00520-025-09990-w","DOIUrl":"10.1007/s00520-025-09990-w","url":null,"abstract":"<p><strong>Purpose: </strong>Neratinib is a pan-human epidermal growth factor receptor (HER) tyrosine kinase inhibitor (TKI) used in the treatment of HER2+ breast cancer. Diarrhea is the most commonly reported toxicity, with the majority experiencing at least some grade of diarrhea. The mechanisms behind neratinib-induced diarrhea are yet to be fully defined, but have been linked to gut microbiome changes, specifically decreased levels of the genera Blautia. This study aimed to investigate the efficacy of Blautia luti (B.luti) administered as a daily probiotic on neratinib-induced diarrhea, and its effects on the gut microbiome in a well-established rat model.</p><p><strong>Methods: </strong>Female albino Wistar (AW) rats (n = 40) were randomly allocated to groups including; vehicle control (VC), neratinib alone, B.luti alone and neratinib + B.luti in different schedules (Pre, Pre & Post or Post). Daily oral gavage administration of B.luti (10⁷CFU/ml) was given according to corresponding schedules, alongside a 28-day cycle of neratinib (50 mg/kg). Diarrhea was graded daily, and faecal samples collected for gut microbiome analysis at study end. Ileum and colon samples were collected for intestinal analysis. 16S rRNA gene sequencing was performed on faecal samples and H&E performed on intestinal tissue for injury evaluation.</p><p><strong>Results: </strong>Grade 3 diarrhea was reduced in the Post group when compared to the neratinib alone group (p = 0.0122). No significant differences were seen in the tissue injury scores of the ileum or colon. There was no significant change in microbial composition with B.luti administration.</p><p><strong>Conclusion: </strong>This study demonstrated that administration of B.luti supplementation, was effective in reducing neratinib-induced diarrhea severity when consumed concurrently. This administration schedule may have a protective role in the intestines through immunomodulation.</p>","PeriodicalId":22046,"journal":{"name":"Supportive Care in Cancer","volume":"33 11","pages":"948"},"PeriodicalIF":3.0,"publicationDate":"2025-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12521284/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145293626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Longitudinal trajectory of menopausal symptoms in premenopausal women throughout adjuvant chemotherapy: a two-stage analytical approach.","authors":"Saim Jung, Jaehyun Kim, Sun Hyung Lee, Joon Sung Shin, Won-Hyoung Kim, Dooyoung Jung, Tae-Yong Kim, Seock-Ah Im, Kyung-Hun Lee, Bong-Jin Hahm, Chan-Woo Yeom","doi":"10.1007/s00520-025-10041-7","DOIUrl":"https://doi.org/10.1007/s00520-025-10041-7","url":null,"abstract":"<p><strong>Purpose: </strong>Breast cancer incidence in Asian women peaks in the mid-40 s, when many remain premenopausal. The progression of chemotherapy-induced menopausal symptoms in this population remains underexplored. This study examined their temporal trajectory and clinical significance during adjuvant chemotherapy.</p><p><strong>Method: </strong>This prospective study assessed breast cancer patients undergoing adjuvant chemotherapy at a tertiary hospital. Participants were classified by menopausal status and treated with AC-D (Adriamycin, Cyclophosphamide, and Docetaxel) or FAC (5-Fluorouracil, Adriamycin, and Cyclophosphamide) regimens. Menopausal symptoms were evaluated using the Menopausal Rating Scale (MRS) at four time points: before chemotherapy (T0), after the first (T1) and fourth (T2) cycles, and one month post-chemotherapy (T3). Symptom trajectories were analyzed using a linear mixed-effects model (LMM) and Generalized Estimating Equations (GEE).</p><p><strong>Results: </strong>Menopausal symptoms significantly worsened in premenopausal women (AC-D: p < 0.001, FAC: p < 0.001), particularly from T2 onward. Psychological symptoms showed the greatest increase (AC-D: p < 0.001, FAC: p < 0.001), followed by significant worsening of urogenital symptoms (AC-D: p = 0.002, FAC: p = 0.004). Somatic symptoms showed a non-significant increasing trend (AC-D: p = 0.120, FAC: p = 0.101). At T3, 67.9% of AC-D and 59.4% of FAC patients experienced moderate-to-severe symptoms, with severe cases doubling in AC-D (from 16.1% at T0 to 37.5%) and tripling in FAC (6.8% at T0 to 18.9%).</p><p><strong>Conclusion: </strong>Chemotherapy-induced menopausal symptoms progressively worsened, particularly psychological symptoms. By treatment completion, approximately two-thirds required clinical intervention, underscoring the need for early assessment and proactive management to improve patient outcomes.</p>","PeriodicalId":22046,"journal":{"name":"Supportive Care in Cancer","volume":"33 11","pages":"945"},"PeriodicalIF":3.0,"publicationDate":"2025-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145293701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nurses' attitudes toward addressing sexual health in their professional practice within cancer care: a Danish cross-sectional study.","authors":"Louise Bregnhøj Mortensen, Line Lønbro Boisen, Bell Møller, Luise Sinding Nygaard, Anna Cecilie Jørgensen, Clara Rosengaard Groth, Kristina Holmegaard Nørskov","doi":"10.1007/s00520-025-09969-7","DOIUrl":"10.1007/s00520-025-09969-7","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate Danish nurses specializing in cancer care in terms of their attitudes toward addressing sexual health in their professional practice.</p><p><strong>Methods: </strong>A nationwide cross-sectional survey was conducted in June-August 2024 among Danish registered nurses working in cancer care. The validated Health Professionals' Attitudes Towards Addressing Sexual Health (PA-SH-D) questionnaire was used to assess attitudes across four domains: comfort, patient encounters, colleagues, and education. Data was analyzed using descriptive statistics and linear regression.</p><p><strong>Results: </strong>A total of 538 nurses completed the survey. Most respondents were female (97.6%) with a mean age of 45.9 years and an average seniority of 18.8 years. The nurses felt comfortable, to some extent, about informing (37.8%), initiating (44.1), and discussing (45%) sexual health issues with patients, although around half of the nurses (45.3%) would not set aside time to deal with sexual health issues. Knowledge about where to seek information and to participate in sexual health training in the past year was significantly associated with higher total PA-SH-D scores (respectively p < 0.001 and p < 0.05). Seniority was positively associated with preparedness (β = 0.18 per year, p < 0.05). Cultural sensitivities, patient discomfort, and lack of time were frequently addressed as barriers.</p><p><strong>Conclusion: </strong>While many Danish oncology and hematology nurses report feeling comfortable discussing sexual health, significant barriers remain. Training and access to relevant resources are associated with greater perceived preparedness. Our findings highlight a critical need for ongoing education and institutional support to integrate sexual health as a standard component of oncology and hematology nursing care.</p>","PeriodicalId":22046,"journal":{"name":"Supportive Care in Cancer","volume":"33 11","pages":"949"},"PeriodicalIF":3.0,"publicationDate":"2025-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12521267/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145293704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oncology's ongoing struggle with evaluating quality of life limiting, treatment-related toxicity.","authors":"Seamus O'Reilly, Siobhan Gaynor, Erica L Mayer","doi":"10.1007/s00520-025-10017-7","DOIUrl":"https://doi.org/10.1007/s00520-025-10017-7","url":null,"abstract":"","PeriodicalId":22046,"journal":{"name":"Supportive Care in Cancer","volume":"33 11","pages":"943"},"PeriodicalIF":3.0,"publicationDate":"2025-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145287047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prophylactic photobiomodulation to reduce oral mucositis in head and neck cancer: an observational study.","authors":"Renata Ferrari, Ana Carolina Felizardo, Lourenço Siqueira, Luana Abreu, Daniele Araújo, Leticia Araujo, Tauana Fernandes, Clara Lopes, Rafaela Peixoto, Bianca Melo, Ana Maria Dias, Ruan Silva, Mariana Tosello Laloni, Bruno Ferrari, Carlos Gil Moreira Ferreira, Eduardo Fregnani, William Nassib William, Cristiane Decat Bergerot","doi":"10.1007/s00520-025-10020-y","DOIUrl":"https://doi.org/10.1007/s00520-025-10020-y","url":null,"abstract":"<p><strong>Purpose: </strong>Oral mucositis (OM) is a common side effect of radiotherapy (RT) and chemoradiotherapy (CRT) in patients with head and neck cancer (HNC). This study investigates the impact of prophylactic photobiomodulation (PBM) on OM incidence in patients with HNC undergoing RT or CRT.</p><p><strong>Methods: </strong>This single-arm, observational study was conducted across multiple cancer centers in Brazil. Baseline assessments included clinical and radiographic dental evaluations, nutritional risk assessment via the Patient-Generated Subjective Global Assessment (PG-SGA), and HPV status determination. All patients received daily prophylactic PBM during RT. OM incidence and severity were assessed daily by a stomatologist using the Common Terminology Criteria for Adverse Events (CTCAE) Version 5.0. Descriptive statistics summarized patient characteristics, and logistic regression identified potential predictors of severe OM (grade 3+).</p><p><strong>Results: </strong>A total of 118 patients with HNC were recruited. The cumulative incidence of OM of any grade was 65.2% (95% CI 60.0-70.4%), with severe OM (Grade 3/4) observed in 28.0% of patients. Risk factors significantly associated with OM included HPV-positive tumor status (OR = 1.65, P = 0.02), concurrent CRT (OR = 1.86, P = 0.002), and nutritional risk (OR = 2.36, P = 0.004). Tumor location also influenced OM risk, with laryngeal cancers showing a lower incidence (OR = 0.72, P = 0.02).</p><p><strong>Conclusion: </strong>Prophylactic PBM appears effective in reducing the incidence and severity of OM among patients with HNC undergoing RT or CRT. These findings support its potential role as a preventive strategy in routine clinical care.</p>","PeriodicalId":22046,"journal":{"name":"Supportive Care in Cancer","volume":"33 11","pages":"944"},"PeriodicalIF":3.0,"publicationDate":"2025-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145293623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}