Supportive Care in Cancer最新文献

{"title":"Clinicians' experiences, perspectives, barriers, and facilitators of integrating palliative care into hematological malignancy care: a qualitative interview study.","authors":"Beaudine M van den Berg, Carly S Heipon, Corine Korf, Anna van Rhenen, Eduardus F M Posthuma, Yvette M van der Linden, H Roeline Pasman, Natasja J H Raijmakers, Linda Brom","doi":"10.1007/s00520-025-09715-z","DOIUrl":"https://doi.org/10.1007/s00520-025-09715-z","url":null,"abstract":"<p><strong>Purpose: </strong>Palliative care is integrated into hematological malignancy care less frequently than in the care for patients with solid tumors. Therefore, this study aimed to better understand the perspectives and experiences of clinicians regarding integrating palliative care for patients with hematological malignancies.</p><p><strong>Methods: </strong>Interviews were conducted with clinicians who care for hematological patients. The interviews were analyzed using thematic analysis.</p><p><strong>Results: </strong>Participants acknowledged the importance of integrating palliative care. However, they noted that patients with hematological malignancies often have a more unpredictable disease course than patients with solid tumors. Unpredictability and the potential for rapid deterioration were identified as main barriers to the integration of palliative care. In addition, participants indicated that the availability of multiple treatment options may result in a tendency to prioritize these treatments over integrating palliative care. The participants recommended that palliative care should have a prominent position in the hematology curriculum and suggested that including palliative care topics in conferences could enhance awareness.</p><p><strong>Conclusions: </strong>To integrate palliative care into hematological malignancy care, it is necessary to enhance the knowledge and awareness of palliative care among hematological clinicians. A two-track approach, where both curative and palliative pathways coexist, could facilitate the integration of palliative care.</p>","PeriodicalId":22046,"journal":{"name":"Supportive Care in Cancer","volume":"33 8","pages":"697"},"PeriodicalIF":2.8,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144660231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterization of multidimensional dyspnea in advanced lung cancer with moderate to severe dyspnea-related functional impairment: a latent profile analysis.","authors":"Stephen B Lo, Joosun Shin, Mia E Holtze, Kathryn E Post, Ijeoma Julie Eche-Ugwu, Jennifer S Temel, Mary E Cooley, Joseph A Greer","doi":"10.1007/s00520-025-09757-3","DOIUrl":"10.1007/s00520-025-09757-3","url":null,"abstract":"<p><strong>Purpose: </strong>Dyspnea impacts most patients with advanced lung cancer. However, research on dyspnea has been limited by using unidimensional self-report measures despite its multidimensional nature (sensory-perceptual experience, affective distress, and functional impact), which requires a comprehensive evaluation. To identify distinct patient profiles of dyspnea presentation and evaluate differences in demographic, clinical characteristics, and patient-reported outcomes (i.e., functional impairment, quality of life, co-occurring symptoms, and self-efficacy).</p><p><strong>Methods: </strong>A cross-sectional, secondary analysis of 247 patients with advanced lung cancer reporting moderate-to-severe dyspnea was conducted using baseline data from a randomized controlled trial testing a behavioral intervention for dyspnea. The patient profiles of dyspnea were identified using latent profile analysis of the Cancer Dyspnea Scale. Differences among the profiles were assessed through parametric and non-parametric methods.</p><p><strong>Results: </strong>Four-class solutions were identified: All Mild (A-Mild: 53%), Moderate Effort and Discomfort & Mild Anxiety (Moderate ED & Mild A: 25.9%), All Moderate (A-Moderate: 16.6%), and All Severe (A-Severe: 4.5%) dyspnea profiles. No significant differences were found among demographic and clinical variables across the profiles. Compared to the A-Mild profile, the other three profiles reported more significant functional impairment due to dyspnea, increased levels of depression, anxiety, and fatigue, and reduced quality of life. The A-Severe profile exhibited lower self-efficacy than the Moderate ED & Mild A and the A-Moderate profiles.</p><p><strong>Conclusion: </strong>Our findings highlight the multidimensional nature of dyspnea, which results in distinct patient presentations. Clinicians can create targeted interventions tailored to individual needs by classifying dyspnea symptom profiles.</p>","PeriodicalId":22046,"journal":{"name":"Supportive Care in Cancer","volume":"33 8","pages":"700"},"PeriodicalIF":2.8,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144668553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Using digital technology to support wellbeing and independence among people living with incurable cancers: a systematic review.","authors":"Jordan Curry, Cristina M Caperchione, Sarah Greenley, Elizabeth Dennis, Cynthia C Forbes","doi":"10.1007/s00520-025-09759-1","DOIUrl":"10.1007/s00520-025-09759-1","url":null,"abstract":"<p><strong>Purpose: </strong>The purpose of this systematic review is to summarise and evaluate the feasibility, acceptability, and potential efficacy of using digital technology to deliver physical activity and/or nutrition interventions to promote wellbeing and independence among adults with advanced or incurable cancer.</p><p><strong>Methods: </strong>Systematic structured searches for any experimental study exploring physical activity and/or nutrition intervention delivery with digital technology were conducted in PsycINFO, MEDLINE, EMBASE, CINAHL, Web of Science Core Collection, and the Cochrane Central Register of Controlled Trials. All records were screened, extracted, and quality assessed by two authors. Main outcomes were feasibility and acceptability of using technology to help deliver interventions, with secondary outcomes of potential efficacy in any measure of quality of life, wellbeing, or function.</p><p><strong>Result: </strong>Twenty-nine eligible studies were included. Digital interventions were mostly feasible and acceptable, with high retention rates and participant satisfaction. Many participants expressed willingness to recommend the interventions to others or continue use. Engagement rates were generally high, although fewer studies addressed diet and nutrition than exercise and physical activity interventions.</p><p><strong>Conclusion: </strong>Digital supportive care interventions may be feasible, well-accepted, and tolerated by individuals with incurable cancer. These platforms could effectively improve this population's support for physical activity and symptom management. However, the heterogeneity in study designs highlights the exploratory nature of these interventions. To advance the field, future research should focus on adequately powered studies, improved generalisability, and standardised tools for measuring outcomes.</p><p><strong>Trial registration: </strong>This trial has been prospectively registered in PROSPERO (ID: CRD42021295936).</p>","PeriodicalId":22046,"journal":{"name":"Supportive Care in Cancer","volume":"33 8","pages":"699"},"PeriodicalIF":2.8,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12274145/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144660234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Health-related quality of life trajectories among older breast cancer survivors: a SEER-MHOS analysis.","authors":"Eunkyung Lee, Sushantti Rupesh, Robert B Hines, Katia Ferdowsi, Maria Eduarda de Azevedo Daruge, Victoria Loerzel","doi":"10.1007/s00520-025-09736-8","DOIUrl":"https://doi.org/10.1007/s00520-025-09736-8","url":null,"abstract":"<p><strong>Background: </strong>As the survival of breast cancer patients continues to improve, health-related quality of life (HRQOL) becomes an important concern in survivorship. However, there is a lack of knowledge regarding long-term changes in HRQOL after diagnosis among older breast cancer survivors. This study examined HRQOL trajectories over 10 years after diagnosis.</p><p><strong>Methods: </strong>Older women diagnosed with breast cancer at age ≥ 65 years in 1998-2017 in the SEER-MHOS database were eligible. These women must have participated in the surveys at least once within 24 months before diagnosis and at least twice within 10 years after diagnosis. HRQOL was measured using the SF-36/VR-12 questionnaire and summarized as physical (PCS) and mental component summary (MCS) scores. Latent class growth analysis was conducted to identify PCS and MCS trajectory groups. Exploratory descriptive analysis was conducted to characterize these groups.</p><p><strong>Results: </strong>A total of 580 women met the eligibility criteria. There were three classes of PCS trajectory, with all showing declining over time with differing starting points: high-declining (35.5%), mid-declining (41.2%), and low-declining (23.3%). Two classes of MCS trajectory were identified with, all showing a maintaining trend: high-stable (72.3%) and low-recovering (27.7%). The individuals in a worse trajectory group were characterized by older age at diagnosis, higher body mass index, lower education, more comorbidities, more difficulty completing activities, and poor health perception at pre-diagnosis.</p><p><strong>Conclusion: </strong>Older women showed declining PCS trajectories after breast cancer diagnosis while maintaining their MCS scores. These results suggest that more active and early interventions are needed to improve HRQOL deterioration in older breast cancer survivors, by incorporating comprehensive geriatric assessment and multidisciplinary geriatric oncology services.</p>","PeriodicalId":22046,"journal":{"name":"Supportive Care in Cancer","volume":"33 8","pages":"696"},"PeriodicalIF":2.8,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144660232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical outcomes in patients with cancer and Gram-negative bloodstream infection: impact of carbapenem resistance.","authors":"Patricia Volkow-Fernández, Saraí Pineda-Benitez, Pamela Alatorre-Fernández, Beda Islas-Muñoz, Consuelo Velázquez-Acosta, Patricia Cornejo-Juárez","doi":"10.1007/s00520-025-09746-6","DOIUrl":"https://doi.org/10.1007/s00520-025-09746-6","url":null,"abstract":"<p><strong>Purpose: </strong>To describe the outcome of cancer patients who present bloodstream infections (BSIs) by Gram-negative bacteria (GNB) and to analyze the impact of carbapenem resistance.</p><p><strong>Methods: </strong>A retrospective study from 2021 to 2023 at a tertiary care oncologic center in Mexico. The study describes demographic, clinical, and microbiological characteristics in oncological patients with GNB-BSI.</p><p><strong>Results: </strong>During the study period, 1348 episodes of bacteremia were included. There were 703 women (52.1%), with a mean age of 50.5 ± 16.3 years. Five hundred thirty-six (39.7%) events were reported in patients with hematological malignancies (HM) and 814 (60.3%) in patients with solid tumors, having differences between both groups in age, gender, neutropenia, and type of BSI. Polymicrobial bacteremia was documented in 111 patients; 1468 GNB were identified. Nine hundred forty-five were classified as susceptible (64.4%), 417 (28.4%) were 3rd generation cephalosporins-resistant (C3R), and 106 (7.2%) were carbapenem-resistant (CR). CR episodes were most frequent in patients with HM, with severe neutropenia, and with > 2 previous episodes of BSI. Mortality at 30 days for the whole group was 21.1% and 37.5% for patients with CR strains. Multivariate analysis for 30-day mortality revealed that age > 60 years, severe neutropenia, bloodstream infection (BSI) other than catheter-related, polymicrobial BSI, ICU admission, CR strains, and inappropriate antimicrobial treatment were identified as risk factors.</p><p><strong>Conclusions: </strong>Oncology patients, particularly those with HM, are a high-risk group for CR-GNB. These patients have a high mortality. Appropriate antimicrobial treatment is crucial for reducing mortality.</p>","PeriodicalId":22046,"journal":{"name":"Supportive Care in Cancer","volume":"33 8","pages":"694"},"PeriodicalIF":2.8,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144643604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The correlation between anger/agitation and other factors including spousal care in home-dwelling older adults with advanced cancer.","authors":"Changying Wang, Jin Wang, Yunwei Zhang, Yi Wang, Ya Yang, Hansheng Ding","doi":"10.1007/s00520-025-09740-y","DOIUrl":"10.1007/s00520-025-09740-y","url":null,"abstract":"<p><strong>Background: </strong>There has been increasing attention on negative emotions in advanced cancer patients. The correlative factors of negative emotions (anger/agitation) and the role of spousal care in older adults with advanced cancer remain limited.</p><p><strong>Methods: </strong>This study was based on large cross-sectional sample data; a total of 117,396 individuals were included, who were conscious, cognitively intact home-dwelling older adults. Multivariable logistic regression analyses were conducted on the correlative factors of anger/agitation and the correlation between anger/agitation and spousal care.</p><p><strong>Results: </strong>Among home-dwelling older adults with advanced cancer, 8.3% reported more feelings of anger/agitation in the past week, which was significantly lower than the results previously reported for other negative emotions (depression and anxiety). It was found that significant positive correlates of anger/agitation in older adults with advanced cancer included education level, receiving formal care, and the number of chronic diseases. Significant negative correlates included advanced age (≥ 80 years), 1-12 outpatient visits, and 1-6 inpatient services in the past year. Emotional expressions among cancer patients may differ markedly between cultural contexts. Spousal care played a positive role in providing emotional support to older adults with advanced cancer and chronic diseases.</p><p><strong>Conclusions: </strong>Older adults with higher education levels were more likely to experience anger/agitation; it is suggested that strategies are tailored to educational levels. Home-dwelling older adults had a reduced likelihood of experiencing anger/agitation. At the end-of-life stage, those who received spousal care, the likelihood of experiencing anger/agitation in both the advanced cancer group and the chronic diseases group was found to be significantly reduced. It was recommended to focus on socioeconomic disparities among older adults with advanced cancer in end-of-life care and to improve home-based palliative care. There is a need to consider the specific type of emotions under different cultural surroundings. Culturally adapted hierarchical strategies are critical for China's aging cancer population on government, community, and technological levels.</p>","PeriodicalId":22046,"journal":{"name":"Supportive Care in Cancer","volume":"33 8","pages":"695"},"PeriodicalIF":2.8,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12267342/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144643606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sexual dysfunction and its impact on quality of life among female haematological cancer patients: a cross-sectional study in Malaysia.","authors":"Gin-Gin Gan, Diana-Leh-Ching Ng, Jesinda Pauline Kerishnan, Chong-Guan Ng","doi":"10.1007/s00520-025-09726-w","DOIUrl":"10.1007/s00520-025-09726-w","url":null,"abstract":"<p><strong>Background: </strong>S exual dysfunction (SD) and quality of life (QoL) are significantly impacted by cancer and its treatments. However, information on sexual function is scarce, particularly among female patients with underlying haematological malignancies in Asia. This study is aimed at determining the prevalence of SD in these patients, identifying associated factors, and examining their effects on QoL.</p><p><strong>Methods: </strong>This cross-sectional study, conducted in Malaysia from 2014 to 2016, involved female patients with haematological malignancies who were on active treatment or had completed active treatment. Sociodemographic and clinical data were obtained through patient interviews and medical records. Sexual functions were assessed using the Female Sexual Function Index, psychological aspects with the Hospital Anxiety and Depression Scale (HADS), and health-related QoL using the European Organisation for the Research and Treatment of Cancer Quality of Life Questionnaire Core 30 version 3.0 questionnaire. Data were analysed using SPSS software.</p><p><strong>Results: </strong>Of the 89 patients recruited, 82% reported SD. Significant associations were found between SD and menopause (OR, 5.7; 95% CI, 1.60-20.34; p = 0.007) and higher HADS-depression score (OR, 1.6; 95% CI, 1.14-2.21; p = 0.006). Patients with SD exhibited lower median scores in Global Health Status/QoL (QL2) (66.7 [IQR 33.3] vs. 91.7 [IQR 33.3], p = 0.009), role function (83.3 [IQR 33.3] vs. 100 [IQR 16.7], p = 0.033), cognitive function (83.3 [IQR 25.0] vs. 100 [IQR 16.7]), and pain (33.3 [IQR 33.3] vs. 0 [IQR 16.7]). Weak positive correlations were observed between FSFI score and QL2 (Rs = 0.252, p = 0.018) and cognitive function (Rs = 0.237, p = 0.026), while a moderate positive correlation was found with role function (Rs = 0.315, p = 0.003).</p><p><strong>Conclusions: </strong>SD is highly prevalent in female patients with haematological cancers, significantly impacting QoL, and this needs to be addressed accordingly.</p>","PeriodicalId":22046,"journal":{"name":"Supportive Care in Cancer","volume":"33 8","pages":"693"},"PeriodicalIF":2.8,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12263468/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144643605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of aromatherapy massage with lavender essential oil on sleep quality, pain, and mental and psychiatric disorders among breast cancer patients undergoing chemotherapy: a randomized controlled trial.","authors":"Fengxian Zhang, Lin Cheng, Sifan Qin, Liwei Wang, Yun Liu, Yuxiu Liu, Jinhong Yang, Shirong Fang, Na An, Yufeng Zhang, Jiang Liu","doi":"10.1007/s00520-025-09741-x","DOIUrl":"10.1007/s00520-025-09741-x","url":null,"abstract":"<p><strong>Objectives: </strong>To assess the effects of aromatherapy massage on sleep quality and mental and psychological disorders in breast cancer survivors (BCS) undergoing chemotherapy.</p><p><strong>Methods: </strong>The study was a prospective, double-blind, randomized, placebo-controlled trial. Eligible breast cancer patients were enrolled in this study. Participants were randomly assigned to either the intervention group (received lavender aromatherapy) or the placebo group (received sweet almond oil massage). Aromatherapists focused their massage on specific areas of the body (from the lumbosacral area to the soles of the feet, and then from the shoulders to the palms of the hands). From baseline to four weeks after the intervention, the Pittsburgh Sleep Quality Index (PSQI) was used to assess sleep quality, the Visual Analog Scale (VAS) was used to assess pain response, the Mini-Mental State Examination (MMSE) score was used to assess cognitive function, the Beck Anxiety Inventory (BAI) was used to assess anxiety, and the Beck Depression Inventory Second Version (BDI-II) was used to assess depression in patients. All statistical analyses were conducted using STATA software (version 16.0), with a P-value < 0.05 considered statistically significant.</p><p><strong>Results: </strong>Ultimately, a total of 96 participants were divided into the intervention group (n = 47) and the placebo group (n = 51). The baseline characteristics were statistically comparable between the two groups. Statistically significant differences were observed in sleep quality scores (7.51 ± 2.90 vs 9.71 ± 2.67, P < 0.001), anxiety scores (20.26 ± 6.73 vs 24.10 ± 6.46, P = 0.005), and pain response (6.66 ± 1.45 vs 7.41 ± 1.19, P = 0.006) of the intervention group compared to the control group at the 4th week post-intervention. However, there was no significant difference in depression scores (29.43 ± 7.17 vs 30.88 ± 6.26, P = 0.286) and cognitive function scores (28.06 ± 1.55 vs 27.51 ± 1.97, P = 0.128) between the two groups.</p><p><strong>Conclusion: </strong>Aroma massage with lavender essential oil may have a positive effect for BCS undergoing chemotherapy and warrants further promotion.</p><p><strong>Trial registration: </strong>This trial was registered at www.</p><p><strong>Clinicaltrials: </strong>gov (Registration Number: NCT06338527, Registration Date: March 28, 2024).</p>","PeriodicalId":22046,"journal":{"name":"Supportive Care in Cancer","volume":"33 8","pages":"689"},"PeriodicalIF":2.8,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144627018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Virtual reality for outpatient management of cancer pain: a pilot dosing study.","authors":"Hunter Groninger, Diana Violanti, Mary Lynn McPherson, Kevin Hopkins, Alaina L Carr, Maria Hurtado, Mihriye Mete","doi":"10.1007/s00520-025-09723-z","DOIUrl":"https://doi.org/10.1007/s00520-025-09723-z","url":null,"abstract":"<p><strong>Purpose: </strong>Growing evidence supports the analgesic benefit of virtual reality (VR) for cancer-related pain. However, little is known about the effects of repeated use in the outpatient setting on chronic cancer pain severity or the ideal \"dose\" of VR interventions to mitigate cancer pain.</p><p><strong>Methods: </strong>Single arm unblinded pilot dosing study. Participants were taught how to use and given a Meta Quest 2 VR headset with hand controllers, instructed to use daily × 10 min for 1 week, then twice-daily × 10 min for 1 week, then \"as needed\" (per participant choice) daily for 1 week. Outcomes were self-reported pain score (SRPS), PROMIS Pain Interference Short Form score, and satisfaction with overall pain management. The study recruited adults living with any solid cancer who reported baseline cancer-related pain ≥ 4/10 from a large urban cancer center in Washington, DC.</p><p><strong>Results: </strong>Thirty-three participants (mean age 55 years (SD = 11); 73% women; 91% African American) were included in the analysis. Linear mixed-effects models demonstrated significant time trends across the 3-week study period for improved SRPS (p = 0.04), pain interference scores (p = 0.001), and satisfaction with overall pain management (p < 0.001). Among participants who had been prescribed as needed opioids to manage their cancer pain, no change was observed in self-reported use of breakthrough opioids (p = 0.49).</p><p><strong>Conclusion: </strong>In this pilot, daily use of VR-delivered distraction therapy improved chronic cancer pain compared to baseline. Twice-daily VR dosing may have helped more than once-daily dosing. Future, larger studies should seek to verify optimal dosing of nonpharmacological VR intervention for cancer pain.</p><p><strong>Trial registration: </strong>NCT05442866 (June 28, 2022).</p>","PeriodicalId":22046,"journal":{"name":"Supportive Care in Cancer","volume":"33 8","pages":"690"},"PeriodicalIF":2.8,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144627022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of different photobiomodulation protocols on the prevention of chemotherapy-induced dysgeusia in breast cancer patients treated with Doxorubicin-Cyclophosphamide: a phase III, randomized, triple-blinded non-inferiority clinical trial.","authors":"Cassia Emanuella Nóbrega Malta, Marcela Maria Fontes Borges, Giulianna Aparecida Vieira Barreto, Gabriella Julião Alves Costa, Lais Oliveira Castro Barroso, André Alves Crispim, José Fernando Bastos de Moura, Paulo Goberlânio de Barros Silva","doi":"10.1007/s00520-025-09756-4","DOIUrl":"https://doi.org/10.1007/s00520-025-09756-4","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the non-inferiority of protocols with red (R) or infrared (IR) lasers alone when compared to the already established protocol of R + IR lasers.</p><p><strong>Methods: </strong>This is a phase III, randomized, triple-blind, non-inferiority, placebo-controlled clinical trial consisting of three study groups (n = 60/group): one receiving R + IR lasers, one receiving only R-laser and IR-placebo and the third with IR-laser and R-placebo (2 J of R-laser and 3 J of IR-laser) in 23-points symmetrically distributed on the tongue. Clinicopathological, sociodemographic data, hematological tests, taste analysis, subjective taste scales (VAS, CTCAE, and STTA), Quality-of-life (OHIP-14), ECOG general health status, body mass index (BMI), CPOD, salivary flow, and other side effects were collected. Chi-square/Fisher's exact tests and Kruskal-Wallis/Dunn (intergroup-analysis) or Friedman/Dunn (intragroup-analysis) tests were used (Margin of non-inferiority: 2-tailed p < 0.05).</p><p><strong>Results: </strong>In the R + IR group, the objective did not reduce significantly (p = 0.873), but in the R-group, there was a significant reduction of taste function (p = 0.020). VAS (p < 0.001), CTCAE (p < 0.001), STTA (p < 0.001), and OHIP-14 (p < 0.001) analysis in the IR-group was significantly worse than the R + IR group. The ECOG parameter showed an improvement in the R + IR group (20%) compared to the R (11.7%) or IR (6.7%) groups over the course of the CT cycles (p = 0.037). There was no difference in BMI (p = 0.251), but the R + IR group gained significantly more weight (p = 0.044) without an increase in the frequency of obesity (p = 0.850). Groups R (p < 0.001) and IR (p = 0.046), but not R + IR (p = 0.369), showed a reduction in salivary flow.</p><p><strong>Conclusion: </strong>Protocols R or IR proved to be inferior to the R + IR laser photobiomodulation protocol.</p><p><strong>Trial registration: </strong>Brazilian Clinical Trials Registry ( www.ensaiosclinicos.gov.br ).</p><p><strong>Approval number: </strong>RBR-9 × 5zrgm.</p><p><strong>Date of registration: </strong>12/07/2023.</p>","PeriodicalId":22046,"journal":{"name":"Supportive Care in Cancer","volume":"33 8","pages":"692"},"PeriodicalIF":2.8,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144627019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}