Supportive Care in Cancer最新文献

{"title":"Mitigating digestive complications and neutropenia in pediatric leukemia through a Persian medicine product of whole wheat-based dietary intervention: a randomized triple-blind placebo-controlled trial.","authors":"Mohammad Ebrahim Zohalinezhad, Saba Barkhori, Omid Reza Zekavat, Foroogh Namjoyan, Mohammadreza Bordbar, Mohammad Hashem Hashempur","doi":"10.1007/s00520-025-09177-3","DOIUrl":"https://doi.org/10.1007/s00520-025-09177-3","url":null,"abstract":"<p><p>Leukemia is a prevalent cancer that severely affects children, and standard chemotherapy often leads to severe gastrointestinal symptoms and neutropenia. This study aimed to discover alternative treatments to prevent neutropenia in pediatric leukemia patients and minimize chemotherapy-related complications. This randomized, placebo-controlled trial was conducted on 52 children between the ages of 3 and 18 years who were suffering from acute leukemia and undergoing chemotherapy. The study included a case and control group. A traditional wheat bran product called \"Wheat Saviq\" was given to the case group with Jollab syrup, while refined wheat flour and a placebo were given to the control group. For 1 month, both groups received a daily dose. Symptoms, weight, and blood cell count were measured before and after the trial. After the intervention, the pain, constipation, and bloating scores in the intervention group were lower than in the control group. Furthermore, the intervention group significantly increased white blood cells (WBC) and red blood cells (RBC). These findings suggest that incorporating wheat bran into the diet of pediatric leukemia patients has great potential in alleviating gastrointestinal symptoms and enhancing immune function. This randomized trial showed that consuming Wheat \"Saviq\" and Jollab syrup effectively reduced gastrointestinal symptoms and improved certain laboratory findings in children with leukemia undergoing chemotherapy. Furthermore, the results align with traditional Persian medicine (TPM) texts and further support the potential benefits of wheat bran for digestion and immune system health. IRCT registration number: IRCT20220410054474N1. Registration date: 2022-05-24, 1401/03/03.</p>","PeriodicalId":22046,"journal":{"name":"Supportive Care in Cancer","volume":"33 2","pages":"117"},"PeriodicalIF":2.8,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143024822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of Patient-Generated Subjective Global Assessment (PG-SGA) and Mini Nutritional Assessment (MNA) for nutritional assessment in hepatocellular carcinoma patients.","authors":"Piyanant Chonmaitree, Asawin Sudcharoen, Piyakorn Poonyam, Nutthawut Laoarphasuwong, Kitsarawut Khuancharee, Ornicha Thititagul","doi":"10.1007/s00520-025-09176-4","DOIUrl":"https://doi.org/10.1007/s00520-025-09176-4","url":null,"abstract":"<p><strong>Background: </strong>Malnutrition affects the prognosis and response to treatment in cancer patients. There is no gold standard for nutritional assessment in patients with hepatocellular carcinoma (HCC). This study aimed to compare Patient-Generated Subjective Global Assessment (PG-SGA) and Mini Nutritional Assessment (MNA) in predicting mortality in HCC patients.</p><p><strong>Method: </strong>We included HCC patients in the outpatient clinic at HRH Maha Chakri Sirindhorn Medical Center. The nutritional status was assessed according to PG-SGA and MNA. Patients were followed up for 1 year to verify the incidence of death and complications.</p><p><strong>Result: </strong>Eighty-nine HCC patients were included. The mean age was 62.2 years. Most of the patients were treated with transarterial chemoembolization. Malnutrition identified by PG-SGA and MNA was 53.9% and 51.7%, respectively. The mortality rate was 2.65 cases per 100 persons. Overall survival rate was 90% and 81.5% at 12 and 24 months, respectively. Patients with malnutrition assessed by PG-SGA and MNA had significantly higher mortality than patients without malnutrition. PG-SGA had a sensitivity of 80% for predicting mortality. PG-SGA had higher accuracy for predicting the mortality of HCC patients than MNA (AUROC PG-SGA 0.7148 and MNA 0.7098).</p><p><strong>Conclusion: </strong>HCC patients with malnutrition were evaluated by PG-SGA and MNA had higher mortality than HCC patients without malnutrition. PG-SGA had higher accuracy in predicting mortality than MNA.</p>","PeriodicalId":22046,"journal":{"name":"Supportive Care in Cancer","volume":"33 2","pages":"116"},"PeriodicalIF":2.8,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143012189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of prophylactic laxatives against opioid-induced constipation: retrospective propensity score matching analysis.","authors":"Yuka Okuda, Toshiyuki Kuriyama, Yoshi Tsukiyama, Toshio Shimokawa, Ke Wan, Tomoyuki Kawamata","doi":"10.1007/s00520-025-09154-w","DOIUrl":"10.1007/s00520-025-09154-w","url":null,"abstract":"<p><strong>Purpose: </strong>Opioid-induced constipation (OIC) is problematic for patients with cancer receiving opioid therapy. Some guidelines recommend initiating regular laxatives at the same time as opioid analgesics. However, the effectiveness of prophylactic laxatives on OIC has not been widely demonstrated. We therefore examined the incidence of OIC among patients with and without prophylactic laxatives within one week after initiating strong opioid analgesics and the factors associated with the incidence of OIC.</p><p><strong>Methods: </strong>Eligible patients were adults with cancer for whom strong opioid analgesics were initiated after admission and who remained hospitalized for over a week. Propensity score matching analysis was used to compare outcomes after adjusting for patient background.</p><p><strong>Results: </strong>In total, 928 patients were enrolled, from which 536 were selected after propensity score matching analysis. The incidence of OIC in patients with prophylactic laxatives was not significantly different from that without prophylactic laxatives (48.1% vs 48.9%, odds ratio (OR) = 0.97, 95% confidence interval (CI): 0.69-1.36). In multivariable logistic analysis, age ≥ 65 years (OR = 1.53, 95% CI: 1.07-2.19) and Eastern Cooperative Oncology Group Performance Status (ECOG PS) ≥ 3 (OR = 1.69, 95% CI: 1.04-2.77) were associated with a higher incidence of OIC.</p><p><strong>Conclusion: </strong>Prophylactic laxatives did not affect the incidence of OIC in our study. Our results suggest that prophylactic laxatives are not necessarily required when initiating opioid therapy. In addition, we found that age ≥ 65 years and ECOG PS ≥ 3 were associated in our study with a higher incidence of OIC.</p>","PeriodicalId":22046,"journal":{"name":"Supportive Care in Cancer","volume":"33 2","pages":"115"},"PeriodicalIF":2.8,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11750890/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143012209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to: The contribution of nonmedical opioid use to healthcare encounters for opioid overdose and use disorders among long‑term users with metastatic cancer.","authors":"Hannah Harsanyi, Lin Yang, Jenny Lau, Winson Y Cheung, Colleen Cuthbert","doi":"10.1007/s00520-025-09161-x","DOIUrl":"https://doi.org/10.1007/s00520-025-09161-x","url":null,"abstract":"","PeriodicalId":22046,"journal":{"name":"Supportive Care in Cancer","volume":"33 2","pages":"114"},"PeriodicalIF":2.8,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143012204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of photobiomodulation and bethanechol chloride treatment on salivary composition and flow rate in head and neck cancer patients undergoing radiotherapy: longitudinal interventional experimental clinical study.","authors":"Natália Schepanski, Bruna Melo da Silva Liebl, Reila Taina Mendes, Floriatan Santos Costa, Clarice D B Amaral, Raquel C Machado, Ana Rita A Nogueira, Laurindo Moacir Sassi, Melissa Rodrigues de Araujo","doi":"10.1007/s00520-024-09120-y","DOIUrl":"https://doi.org/10.1007/s00520-024-09120-y","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the efficacy of photobiomodulation therapy (PBMT) and bethanechol chloride (BC) on the quantity and quality of saliva in patients undergoing radiotherapy (RT) for head and neck cancer.</p><p><strong>Methods: </strong>Saliva samples were collected from patients before and after RT, who were treated with PBMT or BC. Clinical parameters, including salivary flow rate (SFR), pH, xerostomia, and concentrations of macro and microelements in saliva, were assessed. Data were compared and analyzed using a self-organizing map.</p><p><strong>Results: </strong>No significant changes were observed in SFR, pH, and xerostomia pre- and post-RT in both the PBMT and BC-treated groups. However, there was an increase in Cr levels in the BC group and a reduction in P levels in the PBMT group.</p><p><strong>Conclusion: </strong>The results suggest that both PBMT and BC treatments can effectively mitigate the impacts of RT, since quality and quantity of saliva were maintained.</p>","PeriodicalId":22046,"journal":{"name":"Supportive Care in Cancer","volume":"33 2","pages":"113"},"PeriodicalIF":2.8,"publicationDate":"2025-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143012206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Low-risk febrile neutropenia: does combined chemotherapy/immune checkpoint inhibitor necessitate a change in approach?","authors":"Jamie M J Weaver, Bence Nagy, Caroline Wilson, Alexandra Lewis, Anne Armstrong, Tim Cooksley","doi":"10.1007/s00520-025-09168-4","DOIUrl":"https://doi.org/10.1007/s00520-025-09168-4","url":null,"abstract":"<p><strong>Purpose: </strong>Management of patients with low-risk febrile neutropenia in an outpatient setting guided by the MASCC score is proven to be safe and effective. Most patients on ambulatory low-risk febrile neutropenia pathways are undergoing treatment for breast cancer. Recent data has shown benefit of the addition of immune checkpoint inhibitor therapy to cytotoxic chemotherapy in the neoadjuvant setting for patients with early triple-negative breast cancer. We examined whether the addition of ICI therapy altered the clinical severity of febrile neutropenia in this cohort and the ability to manage these patients in an ambulatory setting.</p><p><strong>Methods: </strong>An observational analysis was performed at a specialist oncology hospital in the North West of England. We compared patients with triple negative breast cancer presenting with febrile neutropenia following treatment with PC-EC/pembrolizumab to those treated with PC-EC in the neoadjuvant setting.</p><p><strong>Results: </strong>In the study periods, 152 patients received PC-EC and 151 PC-EC/Pembro. Twenty-five patients presented with FN in the PC-EC/Pembro group compared to 16 in those receiving PC-EC (16% vs 11%, p > 0.05). Patients with febrile neutropenia treated with PC-EC/Pembro had more severe clinical presentations as assessed by the MASCC score (18 vs 24; p = 0.01), had worse physiological parameters (NEWS2 at presentation 3 vs 2; p = 0.023) and had a longer length of hospital stay (median 5 days vs 0 days; p = 0.044). There were no deaths at 30 or 90 days in either cohort.</p><p><strong>Conclusion: </strong>Triple-negative breast cancer patients receiving neoadjuvant pembrolizumab in addition to PC-EC appear to have more severe presentations with febrile neutropenia. This may necessitate greater caution in pathways for ambulatory management for this cohort.</p>","PeriodicalId":22046,"journal":{"name":"Supportive Care in Cancer","volume":"33 2","pages":"112"},"PeriodicalIF":2.8,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143012231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of healthcare professional-implemented interventions on adherence to oral targeted therapy in patients with cancer: a systematic review and meta-analysis.","authors":"Fiona Angus, Wan-Chuen Liao, Victoria Adekoya, Li-Chia Chen","doi":"10.1007/s00520-024-09136-4","DOIUrl":"10.1007/s00520-024-09136-4","url":null,"abstract":"<p><strong>Purpose: </strong>This study investigated the impact of healthcare professional-led interventions on adherence to oral targeted therapy and identified the behavior change techniques (BCTs) underpinning the interventions.</p><p><strong>Methods: </strong>A systematic search of MEDLINE, Embase, APA PsycInfo, CINAHL Plus, PubMed, and Web of Science up to July 2024 identified randomized controlled trials and cohort studies involving adult patients (≥ 18 years) with cancer on oral targeted therapy receiving healthcare professional-led interventions to improve adherence. Adherence-related outcomes, including proportions of patients continuing treatments or with a medication possession ratio (MPR) ≥ 90%, were compared between intervention and control (usual care) groups. Pooled odds ratios (ORs) with 95% confidence intervals (CIs) and heterogeneity (I² statistic) were reported. Differences in median time to treatment discontinuation were calculated and synthesized where applicable. Interventions were categorized using the BCT taxonomy.</p><p><strong>Results: </strong>This review included 11 studies (1,654 patients). The pooled results for proportions of patients continuing treatment (OR 17.91; 95%CI 3.18, 100.73; I² < 0.1%) or with an MPR ≥ 90% (OR 3.67; 95%CI 1.98, 6.80; I² < 0.1%) showed a significantly favorable outcome in the intervention group compared to the control group. In two studies, the median time to treatment discontinuation was longer in the intervention group than in the control group. The most commonly used BCTs were \"credible source\" (n = 11), \"problem-solving\" (n = 9), \"instruction on how to perform a behavior\" (n = 9), and \"pharmacological support\" (n = 8).</p><p><strong>Conclusion: </strong>Despite limited evidence, healthcare professional-led interventions significantly improve treatment adherence. Future studies should tailor strategies for individual needs and apply BCTs in designing effective interventions. PROSPERO registered: no. CRD42024571808.</p>","PeriodicalId":22046,"journal":{"name":"Supportive Care in Cancer","volume":"33 2","pages":"110"},"PeriodicalIF":2.8,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11739221/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143012240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the lived experience of Chinese family caregivers caring for end-of-life cancer patients at home: a phenomenological study in Singapore.","authors":"Seng Hock Martin Ang, Wing Hong Edward Poon, Odette Best, Coralie Graham","doi":"10.1007/s00520-025-09166-6","DOIUrl":"https://doi.org/10.1007/s00520-025-09166-6","url":null,"abstract":"<p><strong>Purpose: </strong>The Chinese community constitutes the largest demographic and faces the highest rates of cancer incidence in Singapore. Given this, palliative care plays a crucial role in supporting individuals, particularly those nearing the end of life, with family serving as their primary source of support. Many Chinese family caregivers in Singapore reported significant unmet needs in cancer care provision, with studies indicating that they often bear the brunt of caregiving responsibilities. Despite this, there has been a lack of research exploring the needs and perspectives of Chinese Singaporean family caregivers caring for terminally ill cancer patients at home. Thus, this study seeks to address this gap by investigating the lived experiences of Chinese Singaporean family caregivers providing end-of-life cancer care in a home setting.</p><p><strong>Methods: </strong>This study employed a hermeneutic phenomenological approach, guided by the framework developed by van Manen (1990), to uncover the essential meaning of each participant's lived experience. In-depth, semi-structured virtual interviews were conducted face-to-face with ten Chinese Singaporean family caregivers. These caregivers shared their personal journeys of caring for a loved one with advanced cancer during their final stage of life at home. The interviews were audio recorded, and open-ended questions were used to facilitate discussion. Each interview lasted between 30 and 60 min. The principal investigator manually transcribed all audio recordings. Additionally, an external transcriber translated the interviews into written form to ensure accuracy and authenticity. The interview texts were then analyzed and interpreted using the philosophical underpinnings rooted in phenomenology.</p><p><strong>Results: </strong>The attempts to identify meanings and make sense of the Chinese Singaporean's lived experience led to the development of two main themes and eight sub-themes. Under the primary theme of \"experiences from caregiving\" comprises the sub-themes \"being a caregiver,\" \"suffering,\" and \"well-being,\" and the major theme of \"expectations in caregiving\" encompasses the sub-themes \"caregiving support,\" \"decision-making,\" \"communication,\" \"spirituality,\" and \"being a Chinese Singaporean\".</p><p><strong>Conclusion: </strong>In conclusion, addressing family caregivers' needs requires culturally sensitive nursing education, peer support initiatives, public awareness campaigns, and enhanced training for domestic helpers. These measures, coupled with further research into diverse cultural caregiving needs and male caregivers' experiences, will improve support systems and empower caregivers in their essential roles.</p>","PeriodicalId":22046,"journal":{"name":"Supportive Care in Cancer","volume":"33 2","pages":"111"},"PeriodicalIF":2.8,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143012224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Physical activity and quality of life among breast cancer survivors: Pink SWAN.","authors":"Brianna N Leitzelar, Sybil L Crawford, Beverly Levine, Kelly R Ylitalo, Alicia B Colvin, Kelley Pettee Gabriel, Gail A Greendale, Nancy E Avis","doi":"10.1007/s00520-025-09156-8","DOIUrl":"10.1007/s00520-025-09156-8","url":null,"abstract":"<p><strong>Purpose: </strong>To describe physical activity (PA) trajectories across 10 years post-breast cancer diagnosis and examine their association with quality of life (QoL).</p><p><strong>Methods: </strong>Participants from the longitudinal Study of Women's Health Across the Nation who developed incident breast cancer completed the Quality of Life in Adult Cancer Survivors scale (QLACS) which has 12 domains. Breast cancer survivors (BCS) with at least one post-diagnosis measure of the Kaiser Physical Activity Survey (PA) were included (n = 96). We estimated metabolic equivalents of task minutes per week (MET-min/week) for the two most frequent sport/exercise activities. Group-based trajectory modeling determined PA trajectories over 10 years post-diagnosis. Analysis of covariance assessed associations between PA trajectory group and the three QLACS domains with the worst scores (fatigue, pain, and recurrence-related distress), adjusted for PA and other relevant covariates.</p><p><strong>Results: </strong>There were four post-diagnosis PA trajectories: consistently very low/no PA (\"inactive,\" 11.5%); consistently some, but below aerobic PA guideline (\"below guideline,\" 48.9%); generally met aerobic PA guideline with a slight decline (\"met guideline,\" 22.2%); and exceeded aerobic PA guideline (\"exceeded guideline,\" 18.8%). In adjusted models, the below guideline group reported more fatigue than the met or exceeded groups and more pain than the met guideline group, but there were no group differences in recurrence-related distress.</p><p><strong>Conclusion: </strong>The majority of BCS did not meet the aerobic PA guideline over 10 years post diagnosis. BCS who met the aerobic PA guideline reported less fatigue and pain compared to those who did not meet the guideline in adjusted analyses, suggesting a negative association between PA and QoL.</p>","PeriodicalId":22046,"journal":{"name":"Supportive Care in Cancer","volume":"33 2","pages":"101"},"PeriodicalIF":2.8,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11735529/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143012154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to: Intermittent catheter clamping combined with active urination training (ICCAUT) to reduce the risk of urinary dysfunction in patients after proctectomy: a single-center cohort study.","authors":"Tingting He, Daguang Wang, Jinhai Yu, Jian Suo, Helei Wang, Donghui Sun, Jiaxin Yang, Liang He, Luyao Zhang, Yan Chen, Jianan Sun, Quan Wang, Yuchen Guo","doi":"10.1007/s00520-025-09167-5","DOIUrl":"https://doi.org/10.1007/s00520-025-09167-5","url":null,"abstract":"","PeriodicalId":22046,"journal":{"name":"Supportive Care in Cancer","volume":"33 2","pages":"105"},"PeriodicalIF":2.8,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143012192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}