Supportive Care in Cancer最新文献

{"title":"A digital workflow for designing and fabricating a split negative mold of obturator for patients with palatal defects.","authors":"Siyi Wang, Fan He, Yuanfei Fu, Xiaoyu Gu","doi":"10.1007/s00520-025-09804-z","DOIUrl":"https://doi.org/10.1007/s00520-025-09804-z","url":null,"abstract":"<p><p>Prosthetic rehabilitation remains the predominant strategy for the reconstruction of maxillary defects. However, conventional impression techniques are often cumbersome and uncomfortable for patients, while the limited precision of medical-grade silicone 3D processing presents additional challenges to achieving optimal prosthetic outcomes. This technical note introduces a novel digital workflow for the design and fabrication of split negative molds for obturator prostheses in post-maxillectomy patients, aiming to address both the discomfort associated with traditional impression-taking and the inaccuracies commonly encountered in prosthesis manufacturing. The proposed protocol integrates spiral computed tomography (CT), reverse engineering, and three-dimensional (3D) printing technologies. CT-derived 3D reconstructions were utilized to accurately capture the morphological characteristics of both soft and hard tissues at the defect site. Defect margin delineation and obturator design were performed using Geomagic Studio 2013 software. Subsequently, a stereolithography apparatus (SLA) was employed to fabricate a split negative mold featuring interlocking alignment structures, which facilitated the production of a hollow silicone obturator. This fully digital approach effectively overcomes several limitations inherent in conventional methods, including patient discomfort during impression-taking and the imprecision associated with traditional silicone prosthesis fabrication. The resulting prosthesis demonstrated favorable clinical outcomes, significantly enhancing patient comfort and restoring essential oral functions such as speech, swallowing, and mastication. Importantly, this technique offers particular advantages for patients with limited mouth opening following maxillectomy.</p>","PeriodicalId":22046,"journal":{"name":"Supportive Care in Cancer","volume":"33 8","pages":"729"},"PeriodicalIF":3.0,"publicationDate":"2025-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144745121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Understanding fungating tumors: a retrospective study on patient characteristics, wound complications, and management insights.","authors":"Ovya Ganesan, Erin Bertagnolli, Joanna Woodman, Elise St Amant, Dennis P Orgill","doi":"10.1007/s00520-025-09777-z","DOIUrl":"10.1007/s00520-025-09777-z","url":null,"abstract":"<p><strong>Purpose: </strong>Chronic fungating tumors inflict profound psychological and physical harm to patients, drastically diminishing their quality of life. However, robust quantitative data characterizing their common issues and survival are scarce. The aim of this study is to better characterize fungating wounds and to suggest management techniques.</p><p><strong>Methods: </strong>We retrospectively reviewed charts of patients who presented with a fungating tumor at Brigham and Women's Wound Care Center between 2019 and 2024. Patient characteristics and outcomes along with wound presentation and complications were collected.</p><p><strong>Results: </strong>Sixty-two patients fit inclusion criteria. Eighty-one percent were women. Patients presented at an average age of 58. Breast cancer (68%) and melanoma (10%) were the most common etiologies. At initial presentation, patients mostly suffered from wound exudate (90%), necrosis (69%), and pain (52%). After initial presentation, 27% were admitted with sepsis, which was statistically associated with mortality, and 24% experienced bleeding episodes. At the time of this study, 61% of patients are still alive. Those who died survived an average of 309 days after presentation. Kaplan-Meier survival estimates 1-, 2-, and 5-year survival at 71%, 59%, and 51%, respectively.</p><p><strong>Conclusion: </strong>Patients may live longer than previously estimated. Emphasizing a palliative, patient-centered approach may significantly enhance quality of life. Further research is essential to advancing evidence-based strategies and optimizing outcomes.</p>","PeriodicalId":22046,"journal":{"name":"Supportive Care in Cancer","volume":"33 8","pages":"725"},"PeriodicalIF":3.0,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144733345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Developing a patient-centered educational video series on sexual health for women with breast cancer.","authors":"Monica Adams, Madeline G Higgins, Sudheer R Vemuru, Victoria Huynh, Helen L Coons, Erin Baurle, Kristin E Rojas, Karen Hampanda, Lauren Zimmaro, Ashley Arkema, Laura Bozzuto, Elizabeth Fleagle, Kimberly Makela, Keith Singer, Sarah E Tevis","doi":"10.1007/s00520-025-09790-2","DOIUrl":"10.1007/s00520-025-09790-2","url":null,"abstract":"<p><strong>Purpose: </strong>Although breast cancer negatively impacts many patients' sexual health, clinician-provided sexual health educational materials are lacking. This study describes the novel development of educational materials intended to prepare patients for the potential sexual health side effects of their treatment.</p><p><strong>Methods: </strong>Based on focus group results, educational scripts and video segments were created to provide sexual health and general breast cancer education. The content was iteratively modified through collaboration among patients, breast surgeons, medical oncologists, plastic surgeons, sexual health psychologists, and registered nurses. The understandability of the videos was tested among previous focus group participants.</p><p><strong>Results: </strong>Script feedback. A multidisciplinary team developed the initial video scripts. Patients (n = 2) and an external clinical expert (n = 1) provided feedback on the scripts in semi-structured interviews. Patients recommended changes in terminology and additional content on body image. The clinical expert recommended additional content on arousal, prevention of sexually transmitted infections, and body image. Video-based educational materials. A non-profit organization began filming videos in Fall 2022 and completed filming in Summer 2023. In total, 56 videos were filmed (79 min, 15 s of content, 01:25 mean duration). Speakers included patients, clinicians, sexual health experts, and advocates. Video feedback. The multidisciplinary development team reviewed the videos and recommended reorganizing video segments, changing stock video clips, and simplifying complex terminology. Additional filming to incorporate feedback was completed in May 2023. PEMAT-A/V. Overall, the videos had an understandability score of 93.9 ± 4.7. Individual subscales also had favorable understandability scores > 88.9.</p><p><strong>Conclusions: </strong>We developed a novel educational video series for patients undergoing breast cancer treatment. The initial testing of this video-based intervention highlights its potential to enhance knowledge and improve quality of life for the millions of women living with breast cancer by addressing critical aspects of sexual health. Further work to evaluate the feasibility, appropriateness, and acceptability of this video-based intervention to improve sexual health in breast cancer patients is necessary.</p>","PeriodicalId":22046,"journal":{"name":"Supportive Care in Cancer","volume":"33 8","pages":"724"},"PeriodicalIF":3.0,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144733341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on \"Communication and fear of cancer recurrence in colorectal cancer survivors and their partners\".","authors":"Keerthi Sanapala, Rachana Mehta, Ranjana Sah","doi":"10.1007/s00520-025-09792-0","DOIUrl":"https://doi.org/10.1007/s00520-025-09792-0","url":null,"abstract":"","PeriodicalId":22046,"journal":{"name":"Supportive Care in Cancer","volume":"33 8","pages":"726"},"PeriodicalIF":3.0,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144733340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating recruitment, retention, and adherence patterns in the GET FIT fall prevention exercise trial in older, postmenopausal cancer survivors.","authors":"Jessica Sitemba, Mary Crisafio, Fuzhong Li, Elizabeth Eckstrom, Kerri M Winters-Stone","doi":"10.1007/s00520-025-09767-1","DOIUrl":"10.1007/s00520-025-09767-1","url":null,"abstract":"<p><strong>Purpose: </strong>The GET FIT trial tested fall prevention exercise approaches in older (50-75 years) post-chemotherapy, postmenopausal cancer survivors. We describe recruitment, retention, and adherence patterns from GET FIT to inform future trials.</p><p><strong>Methods: </strong>Participants were recruited through multiple strategies (e.g., cancer and research registries, clinician referral, outreach, electronic health record (EHR) screening) and were randomized to one of three supervised, facility-based, group exercise programs (strength training, tai ji quan, or stretching control) for 6 months and then were followed for 6 months after supervised training stopped. We compared effectiveness of accrual across recruitment strategies, examined characteristics of women who completed the interventions to those who withdrew, and women with good (≥ 50%) versus poor (< 50%) adherence to training.</p><p><strong>Results: </strong>Of 1490 interested women, 442 women were eligible, randomized, and received the assigned intervention (30% accrual rate). Accrual was similar across recruitment strategies, except for EHR screening which yielded no accruals. Retention over 12 months was 87% with most dropouts occurring within the first month. There were no differences in baseline characteristics between women who did or did not drop out. Poor adherers (n = 60) had higher baseline BMI, comorbidities, pain, disability, and lower physical functioning (p < 0.05) compared to more adherent women (n = 377).</p><p><strong>Conclusions: </strong>A variety of recruitment strategies appear to be effective for enrolling older, postmenopausal cancer survivors into a facility-based exercise trial, except for directly approaching women identified through the EHR. Women with poorer health were at risk for study drop-out and poor adherence to exercise.</p><p><strong>Implications for cancer survivors: </strong>Women with poorer initial health may need additional retention strategies to help them stick with supervised, facility-based, group exercise.</p><p><strong>Trial registration: </strong>Clinicaltrials.gov: NCT01635413.</p>","PeriodicalId":22046,"journal":{"name":"Supportive Care in Cancer","volume":"33 8","pages":"727"},"PeriodicalIF":3.0,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144733343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spiritual care experiences of nurses caring for cancer patients in China: a qualitative research.","authors":"Jiajun Yuan, Xiaohan Hu, Miaorui Jiao, Thomas Kwok Shing Wong, Li Chen, Yan Li Hu","doi":"10.1007/s00520-025-09786-y","DOIUrl":"10.1007/s00520-025-09786-y","url":null,"abstract":"<p><strong>Purpose: </strong>Cancer is a significant public health issue, and with rising living standards, patients increasingly prioritize quality of life. This has heightened the demand for spiritual care. Despite its proven benefits, research on spiritual care experiences in China remains limited. This study aims to explore Chinese nurses' experiences in providing spiritual care to cancer patients.</p><p><strong>Method: </strong>Semi-structured face-to-face interviews were conducted with 15 purposively sampled nurses from a tertiary oncology hospital in China during May 2023. This study employed a combined approach of induction and deduction in content analysis to analyze the data.</p><p><strong>Results: </strong>Four key themes emerged: (1) experiences and needs related to spiritual care training, (2) emotional resonance in spiritual care, (3) the dual benefits of spiritual care for both nurses and patients, and (4) dual-dimensional influencing factors in spiritual care implementation, including caregiver-related and patient-related factors.</p><p><strong>Conclusions: </strong>This study emphasizes the necessity of culturally adaptive spiritual care training in Chinese oncology nursing and its dual benefits. China's humanistic approach holds unique value compared to Western religious models. Despite multiple challenges, there is significant development space. Integrating spiritual care with cultural norms can enhance patient outcomes and nurses' growth, calling for flexible and standardized protocols to ensure broader applicability.</p>","PeriodicalId":22046,"journal":{"name":"Supportive Care in Cancer","volume":"33 8","pages":"723"},"PeriodicalIF":3.0,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144733344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patient-reported pain severity is associated with shorter survival in older adults with newly diagnosed cancer.","authors":"Jennifer Gabbard, Scott Isom, Tiffany Statler, Joanna Asselin, Kathryn E Callahan, Nicholas M Pajewski, Lynne I Wagner, Armida Parala-Metz, Janet A Tooze, Heidi D Klepin","doi":"10.1007/s00520-025-09779-x","DOIUrl":"10.1007/s00520-025-09779-x","url":null,"abstract":"<p><strong>Purpose: </strong>Pain is a prevalent and often undertreated symptom among older adults with cancer. This study examined whether self-reported pain levels are associated with overall survival (OS) in older adults newly diagnosed with cancer receiving chemotherapy.</p><p><strong>Methods: </strong>This retrospective cohort study included patients aged ≥ 65 years with newly diagnosed lung, colorectal, or breast cancer between 2017 and 2020, identified via a cancer registry at an academic medical center. Self-reported pain using the numeric rating scale (0-10), documented within 30 days of chemotherapy initiation, was categorized as none (0), mild (1-4), moderate (5-7), or severe (8-10). Baseline demographics, opioid use, and frailty (measured using a deficit accumulation approach) were collected. Kaplan-Meier was used to compare OS between groups. Cox proportional hazards models evaluated the association between pain levels and OS, adjusting for demographics, cancer stage and type, opioid use, and frailty.</p><p><strong>Results: </strong>Among 509 patients (median age 72.2 years; 55% female; 83.5% white; 13.4% Black), pain was highly prevalent: 16.5% reported mild, 19.6% moderate, and 17.3% severe pain. Median OS was significantly lower for patients with severe pain (9.1 months, 95% CI 6.5-12.7) compared to those with no pain (29.1 months, p < 0.0001). Severe pain (HR 1.60, 95% CI 1.14-2.24) and moderate pain (HR 1.52, 95% CI 1.10-2.10) were independently associated with higher mortality.</p><p><strong>Conclusions: </strong>Self-reported pain was significantly associated with reduced OS in older adults with cancer. These findings suggest that self-reported pain may serve as a clinical indicator of poor prognosis and support the role of routine pain assessment in identifying high-risk patients to support patient-centered care.</p>","PeriodicalId":22046,"journal":{"name":"Supportive Care in Cancer","volume":"33 8","pages":"722"},"PeriodicalIF":3.0,"publicationDate":"2025-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12296996/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144718698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of a community-based remotely delivered exercise program (2Unstoppable Strong) for women diagnosed with cancer.","authors":"Angela J Fong, Isabel L Wakefield, Betoul Ali, Ilana Gamerman, Stacey Mann","doi":"10.1007/s00520-025-09772-4","DOIUrl":"10.1007/s00520-025-09772-4","url":null,"abstract":"<p><strong>Purpose: </strong>Few remote-delivered physical activity (PA) interventions leverage a community-academic partnership, which may impact sustainability. The current study aimed to assess the satisfaction  with a community-based remote-delivered group-based PA program (2Unstoppable Strong) among women diagnosed with cancer and the preliminary impact of the intervention on exploratory outcomes (PA levels, perceived social support, exercise self-efficacy, barrier self-efficacy, and health-related quality of life).</p><p><strong>Methods: </strong>Online questionnaires were administered at baseline (T0), post-program (T1), and follow-up (T2). Quantitative analyses included descriptive statistics and repeated measures analyses of variance. Open responses at the end of the questionnaire were used to identify areas of improvement. Content analysis was used to analyze the open response data.</p><p><strong>Results: </strong>Participants rated 2Unstoppable Strong as satisfactory (M_score = 4.7, SD = 0.54; M_range = 2.93 to 5.00). Moderate-to-vigorous physical activity significantly increased from T0 to T1 to T2 (F (2, 34) = 3.5, p < .05). From T0 to T1 to T2, both perceived social support quantity (F (2, 34) = 18.6, p < .001) and quality (F (2, 34) = 13.9, p < .001) significantly increased. All exploratory outcomes did not significantly change. Participants enjoyed interacting with the trustworthy instructors and found the videoconferencing software convenient to use. Areas for improvement included facilitating social interaction within the exercise group, increasing the intervention duration, and providing additional sessions.</p><p><strong>Conclusions: </strong>Based on the promising findings, future hybrid implementation-effectiveness studies with larger and more-diverse populations are needed to examine the impact of 2Unstoppable Strong on cancer-related outcomes.</p>","PeriodicalId":22046,"journal":{"name":"Supportive Care in Cancer","volume":"33 8","pages":"721"},"PeriodicalIF":3.0,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12296796/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144718663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A new olfactory rehabilitation protocol based on physiological induction of nasal airflow after total laryngectomy: the Physiological Olfactory Recovery Technique (PORT).","authors":"Lucrezia Spadera, Pietro De Luca, Pasquale Viola, Giuseppina Mirra, Alessandra Petti, Sabino Marrone, Arcangelo Menna, Emilio Avallone, Federico Maria Gioacchini, Angelo Camaioni, Giuseppe Tortoriello, Giuseppe Chiarella","doi":"10.1007/s00520-025-09766-2","DOIUrl":"10.1007/s00520-025-09766-2","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate whether a new nasal airflow induction manoeuvre based on the Physiological Olfactory Recovery Technique (PORT) could be an effective alternative to current techniques for restoring olfactory function in laryngectomised patients.</p><p><strong>Methods: </strong>This is a prospective observational cohort study, including patients who underwent total laryngectomy (TL) and primary tracheoesophageal puncture (TEP) placement for advanced laryngeal cancer (LC). To restore olfactory function, all patients underwent 10 sessions of PORT rehabilitation training at least 2 months after surgery. Outcomes in terms of olfactory acuity, subjective symptoms, and HRQoL were assessed using olfactometry and two structured questionnaires (the Chemosensory Complaints Score and University of Washington Quality of Life version 4), before and after treatment, and after a 6-month follow-up.</p><p><strong>Results: </strong>Twenty laryngectomised patients (15 men and 5 women, with a mean age of 65 ± 8 years) were enrolled in the study. These patients underwent proprioceptive training with a speech and language therapist and learnt the PORT method. Seventeen patients who were unable to smell before treatment became able to smell, while the remaining three patients, who were hyposmic at the beginning of treatment, became normosmic by the end. Following 10 sessions of the rehabilitation programme, all 20 patients demonstrated significant improvements across all outcome measures. These results were maintained in the long term.</p><p><strong>Conclusion: </strong>For laryngectomised patients, PORT is an effective alternative to the Nasal Air Flow Induction Maneuver (NAIM) for olfactory rehabilitation. This technique enabled all rehabilitated patients to regain their daily 'olfactory gesture' physiologically.</p>","PeriodicalId":22046,"journal":{"name":"Supportive Care in Cancer","volume":"33 8","pages":"719"},"PeriodicalIF":3.0,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144708826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patient-directed behavioral-physical interventions to alleviate acute hiccups associated with chemotherapy: a prospective randomized controlled trial.","authors":"Xiaozhen Luo, Lingling Xie, Lili Yang, Jing Chen, Jie Xian, Liping Tong, Yuming Wan, Yu Tang, Jiang Zhu","doi":"10.1007/s00520-025-09758-2","DOIUrl":"10.1007/s00520-025-09758-2","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the feasibility and efficacy of patient-directed behavioral-physical intervention (BPI) for acute hiccups after chemotherapy in cancer patients.</p><p><strong>Methods: </strong>In this prospective randomized controlled trial, cancer patients scheduled for chemotherapy were randomized into the BPI group and the control group. Patients in the BPI group were provided the Hiccup Knowledge Manual and instructional videos on six non-pharmacological behavioral-physical interventions for hiccups and were encouraged to use the interventions when they experienced acute chemotherapy-induced hiccups (CIH). The control group received routine medical attention. The primary endpoint was the median time to acute hiccup remission. The secondary endpoint was the incidence of anxiety and depression in patients and their family caregivers.</p><p><strong>Results: </strong>A total of 654 patients scheduled to receive chemotherapy were enrolled and randomly assigned (1:1) to the BPI group or the control group. After chemotherapy, 57 patients in the BPI group and 49 patients in the control group experienced acute hiccups. The median acute hiccup remission time was significantly shorter in the BPI group [0.17 h (95% CI 0.13 to 0.21 h)] than that in the control group [3.00 h (95% CI 1.48 to 4.52 h)] (P < 0.01). The mean anxiety and depression scores of patients were significantly lower in the BPI group than that in the control group (7.21 vs. 9.86, P < 0.01; 7.40 vs. 10.27, P < 0.01, respectively). Similarly, the average anxiety and depression scores of family caregivers were significantly lower in the BPI group than in the control group (3.91 vs. 8.31, P < 0.01; 4.30 vs. 8.90, P < 0.01, respectively).</p><p><strong>Conclusion: </strong>Learning and self-directed implementation of behavioral-physical interventions have potential effects in shortening the median time to remission of acute CIH. It may also reduce anxiety and depression in patients and their family caregivers. Due to the limitations of this preliminary study, further research is warranted.</p><p><strong>Trial registration: </strong>The study complied with relevant Chinese laws, rules, and regulations (Measures for the Ethical Review of Biomedical Research Involving Humans, etc.), as well as the WMA Declaration of Helsinki and the CIOMS International Ethics Guidelines for Human Biomedical Research, and followed the protocol approved by the medical ethics committee and the informed consent form to carry out clinical trials (research) to protect the health and rights of subjects. This study was approved by the Ethics Committee of Shangjin Nanfu Hospital West China Hospital and was registered in the World Health Organization (WHO) international clinical trials registered organization registered platform ( https://www.chictr.org.cn ; ChiCTR2400081049; February 21, 2024).</p>","PeriodicalId":22046,"journal":{"name":"Supportive Care in Cancer","volume":"33 8","pages":"717"},"PeriodicalIF":3.0,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12296986/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144708829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}