Supportive Care in Cancer最新文献

{"title":"Consultations of patients with cancer to enhance shared decision-making in Japan: A retrospective observational study.","authors":"Ayako Okuyama, Yukie Takemura, Minako Sasaki, Takahiro Higashi","doi":"10.1007/s00520-025-09408-7","DOIUrl":"https://doi.org/10.1007/s00520-025-09408-7","url":null,"abstract":"<p><strong>Purpose: </strong>Treatment decisions are often highly complex when the outcomes are uncertain. In Japan, the consultation fees incurred can be reimbursed when physicians and nurses work together with patients to provide shared decision-making (SDM) on treatment plans. However, the extent to which reimbursed consultations are used by clinicians is unclear. This study aimed to determine the extent to which so-called \"reimbursed SDM consultations\" are used in cancer treatment and to identify the characteristics of patients having these consultations using a nationwide database.</p><p><strong>Methods: </strong>This retrospective study used health service utilization data linked to hospital-based cancer registries from 591 hospitals in Japan. Data for patients aged 18 years or above diagnosed with cancer in 2019 were analyzed. Multivariable logistic regression analysis was conducted to analyze the association between reimbursed SDM consultations and patient characteristics.</p><p><strong>Results: </strong>Overall, 74,828 patients (12.2%) received reimbursed SDM consultations in 533 hospitals. The presence of breast cancer (odds ratio (OR) = 2.00), treatment types of radiotherapy (OR = 1.86) and pharmacotherapy (OR = 1.76), and distant metastasis (OR = 1.49) and the invasion of adjacent organs (regional) (OR = 1.47) were positively associated with reimbursed SDM consultations. Cervical (OR = 0.38) and renal cancers (OR = 0.49) were negatively associated with reimbursed SDM consultations.</p><p><strong>Conclusion: </strong>This study is the first to determine the extent to which reimbursed SDM consultations are used and the characteristics of the patients receiving them. Further studies should investigate the factors influencing the use of reimbursed SDM consultations.</p>","PeriodicalId":22046,"journal":{"name":"Supportive Care in Cancer","volume":"33 4","pages":"335"},"PeriodicalIF":2.8,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143754528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sexual dysfunction in women with breast cancer: a systematic review.","authors":"Nelson Rodrigues-Machado, Xavier Bonfill-Cosp, M Jesús Quintana, Marilina Santero, Ana Bártolo, Anna Selva Olid","doi":"10.1007/s00520-025-09352-6","DOIUrl":"10.1007/s00520-025-09352-6","url":null,"abstract":"<p><strong>Purpose: </strong>This systematic review aims to assess the prevalence, incidence, and risk factors for sexual dysfunction (SdF) in women with breast cancer (BC).</p><p><strong>Methods: </strong>A systematic search was conducted in MEDLINE (PubMed), PsycINFO, Web of Science, and CINAHL to identity longitudinal, observational studies assessing SdF in women with BC. Data extraction followed PRISMA guidelines. The Joanna Briggs Institute checklist was used to assess methodological quality. Results were narratively synthesised.</p><p><strong>Results: </strong>A total of 16 studies involving 4058 women met the inclusion criteria. Overall, the reported prevalence of SdF ranged from 17.5% before BC diagnosis to 86% after 6 months of hormone therapy. Only one study reported incidence data. The six most commonly studied SdF domains were desire, arousal, lubrication, orgasm, satisfaction, and dyspareunia. A significant number of risk factors associated with different dimensions of SdF were identified.</p><p><strong>Conclusion: </strong>SdF is highly prevalent in women with BC, particularly in the first year after diagnosis and treatment. These findings strongly suggest that SdF should be routinely assessed as part of survivorship care protocols. Due to the scant data on incidence rates and the wide variability in reported risk factors, significant gaps remain in our understanding of the onset and progression of SdF in patients with BC. Well-designed cohort studies are needed to better establish the incidence and aetiology of SdF in this patient population.</p>","PeriodicalId":22046,"journal":{"name":"Supportive Care in Cancer","volume":"33 4","pages":"332"},"PeriodicalIF":2.8,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11958476/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143754516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A qualitative exploration of factors that influence engagement with a digital mental health intervention for women with metastatic breast cancer: Finding My Way-Advanced.","authors":"Stephanie Bourboulis, Emma Kemp, Lisa Beatty","doi":"10.1007/s00520-025-09379-9","DOIUrl":"10.1007/s00520-025-09379-9","url":null,"abstract":"<p><strong>Purpose: </strong>While digital mental health interventions (DMHI) may improve access to timely support for women with metastatic breast cancer (MBC), scant research exists on how metastatic survivors engage with these programs and what factors impact usage. This study therefore qualitatively explored barriers and facilitators influencing engagement with (a) digital resources (e.g., information websites) generally and (b) in particular, Finding My Way-Advanced (FMW-A), an interactive self-directed DMHI containing psychoeducation, therapeutic activities, and multimedia content tailored for women with MBC.</p><p><strong>Methods: </strong>Twenty women with MBC, who received either the FMW-A 6-week intervention (n = 13) or a digital-resource control (n = 7) as part of a larger RCT, participated in semi-structured interviews. Transcripts were coded using framework analysis against three domains of Bowen's feasibility framework (acceptability, demand, practicality).</p><p><strong>Results: </strong>Engagement was high among intervention participants overall (six modules completed n = 3; five n = 5; four n = 1; two n = 4). Five overarching themes were identified. Three a priori domains related to FMW-A have high acceptability and practicality, but some demand barriers. Two inductively derived themes related to varied perceptions of navigability/layout and deriving personal benefits/impact. Key subtheme facilitators were program satisfaction, convenience, experiencing personal benefits/impact, and ease of navigation. Subtheme barriers were technical access barriers, experiencing time burden, and suboptimal intervention timing relative to time since diagnosis.</p><p><strong>Conclusions: </strong>This study confirms that while many DMHI facilitators and barriers are consistent with those identified in curatively treated settings, some factors become more salient in metastatic populations (e.g., time burden). This research also offers novel insights that deriving early personal benefit promotes engagement and provides targets for future program improvements to address navigation and optimal-timing challenges.</p>","PeriodicalId":22046,"journal":{"name":"Supportive Care in Cancer","volume":"33 4","pages":"333"},"PeriodicalIF":2.8,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11958373/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143754206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trajectory of change in symptom patterns among patients undergoing surgery for oesophageal cancer: a prospective longitudinal study using latent transition analysis.","authors":"Xuanxuan Ma, Mengmeng Yuan, Lijun Wu, Shaoxue Li, Jie He, Di Wang, Shuwen Li","doi":"10.1007/s00520-025-09375-z","DOIUrl":"https://doi.org/10.1007/s00520-025-09375-z","url":null,"abstract":"<p><strong>Purpose: </strong>Patients with oesophageal cancer may experience a heavy burden of postoperative symptoms. There is insufficient evidence to fully explain the role of symptom clusters in the trajectory of cancer care for patients with oesophagectomy. The aim of this study was to identify the change trajectory of individual symptoms after surgery.</p><p><strong>Methods: </strong>A prospective longitudinal study was conducted to investigate patients' experience of symptoms at four time points after surgery. Latent profile analysis was used to identify patients' unique postoperative symptom experiences, and latent transition analysis was used to identify changes in patient symptom patterns across time points.</p><p><strong>Results: </strong>Among the 398 patients, there were three symptom groups: the \"persistent fatigue group\", \"fluctuating physical symptoms group\", and \"high symptoms group\". Over time, the \"persistent fatigue group\" had a greater than 70% probability of remaining in this group, while the \"fluctuating physical symptoms group\" and \"high symptoms group\" had a large change in transition. Anastomotic site, primary caregiver, and cancer stage were found to predict the pattern of transition between symptom groups.</p><p><strong>Conclusions: </strong>Patients' experience of symptoms changes over time, and it is important to target interventions based on the trajectory of symptoms to improve symptom management in oesophageal cancer patients.</p>","PeriodicalId":22046,"journal":{"name":"Supportive Care in Cancer","volume":"33 4","pages":"334"},"PeriodicalIF":2.8,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143754445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of a family-management program for family having children with acute lymphoblastic leukemia: a quasi-experimental study.","authors":"Wachareekorn Aungkaprasatchai, Nujjaree Chaimongkol, Pornpat Hengudomsub, Verna L Hendricks-Ferguson","doi":"10.1007/s00520-025-09376-y","DOIUrl":"https://doi.org/10.1007/s00520-025-09376-y","url":null,"abstract":"<p><strong>Purpose: </strong>To examine the impact of a family-management program (FMP) on family management, family, and child quality of life (QOL) among parents of children with acute lymphoblastic leukemia (ALL).</p><p><strong>Methods: </strong>Participants included 46 parents of children aged 2-5 years with ALL. Participants were recruited via a convenience sampling method at a tertiary hospital in Thailand. Twenty-three intervention participants received a 3-weekly FMP and routine care while the other 23 control participants received only routine cancer care. Data was collected in the hospital setting and/or via telephone follow-up calls. Study outcomes were evaluated at 3 time points (i.e., baseline, post-intervention, and follow-up) using the following: Family Management Measure, Beach Center Family Quality of Life Scale, and Quality of Life of Children with cancer module. Data were analyzed using two-way repeated-measures analysis of variance (ANOVA).</p><p><strong>Results: </strong>The findings revealed that family management and child QOL in the intervention group was higher than the control group at follow-up (p < .05), but not for family QOL. Within the intervention group, there was significant improvement in family management, family QOL and child QOL at post-intervention and follow-up.</p><p><strong>Conclusions: </strong>The FMP was effective in fostering improved outcomes among enrolled parents that received the FMP compared to parents in the control group. Healthcare providers, especially nurses that work with parents of children with ALL, can easily offer the FMP to parents to help foster optimal family management, family QOL, and child QOL.</p>","PeriodicalId":22046,"journal":{"name":"Supportive Care in Cancer","volume":"33 4","pages":"331"},"PeriodicalIF":2.8,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143754533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to: Patterns and predictors of symptom burden and posttraumatic growth among cancer patients.","authors":"Dongyu Song, Yongfang Bai, Yuzhou Liu, Yuli Li","doi":"10.1007/s00520-025-09411-y","DOIUrl":"https://doi.org/10.1007/s00520-025-09411-y","url":null,"abstract":"","PeriodicalId":22046,"journal":{"name":"Supportive Care in Cancer","volume":"33 4","pages":"329"},"PeriodicalIF":2.8,"publicationDate":"2025-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143743960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between the Chinese Dietary Balance Index-based dietary quality and depressive symptoms in breast cancer patients.","authors":"Xiao-Yun Cao, Gusonghan Maitiniyazi, Yu-Ting Wang, Shu-Fang Xia, Xiao-Yun Shi","doi":"10.1007/s00520-025-09360-6","DOIUrl":"https://doi.org/10.1007/s00520-025-09360-6","url":null,"abstract":"<p><strong>Purpose: </strong>This cross-sectional study explored the association between dietary quality and the risk of depressive symptoms in breast cancer patients.</p><p><strong>Methods: </strong>Dietary intake was assessed by 3-day, 24-h dietary recall, followed by dietary quality evaluation by the Chinese Dietary Balance Index-16 (DBI-16). Depressive symptoms were assessed by Center for Epidemiologic Studies Depression Scale (CES-D).</p><p><strong>Results: </strong>A total of 160 breast cancer patients with a mean age of 53.07 ± 9.50 years were recruited. Fifty of these patients had a CES-D score higher than 16 and were defined as depressed. Compared with non-depressed patients, depressed patients had significantly inadequate fruit intake (P = 0.002). A higher proportion of depressed patients had moderately inadequate dietary intake (lower bound scores, LBS, between 25 ~ 36) compared with non-depressed patients (14.0% vs. 0.9%), and there was a significant difference in the distribution of inadequate intake levels between the two groups (P = 0.003). The depressed patients also had a significantly lower diet variety (P = 0.009). Logistic regression analysis showed that after controlling for age, menopausal status, and employment, LBS was positively associated with depressive symptoms (OR = 1.086; 95% CI 1.005-1.174; P = 0.036), whereas the fruit score (OR = 0.674; 95% CI 0.522-0.871; P = 0.003) and diet variety score (OR = 0.637; 95% CI 0.462-0.878; P = 0.006) were both negatively associated.</p><p><strong>Conclusion: </strong>Diet might be one of the determinants of depressive symptoms in breast cancer patients. A balanced diet with more fruits, increased diet variety, and adequate nutrients might be a promising strategy to prevent or treat depressive symptoms in breast cancer patients.</p>","PeriodicalId":22046,"journal":{"name":"Supportive Care in Cancer","volume":"33 4","pages":"330"},"PeriodicalIF":2.8,"publicationDate":"2025-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143743959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preventing chemotherapy-induced ovarian damage through PI3K/AKT and Hippo pathway regulation.","authors":"Negin Zatalian, Azam Dalman, Hamid Gourabi","doi":"10.1007/s00520-025-09344-6","DOIUrl":"https://doi.org/10.1007/s00520-025-09344-6","url":null,"abstract":"<p><p>Advances in cancer treatment have increased survival rates; however, chemotherapy drugs can impair ovarian reserve via pathways such as PI3K/AKT and Hippo, leading to infertility. Conventional fertility preservation options have limitations. Therefore, agents that prevent or reduce the ovarian side effects of chemotherapy should be investigated. This review explored treatments for preserving ovarian reserve by regulating the PI3K/AKT and Hippo pathways during chemotherapy. When treated with cyclophosphamide and cisplatin, 33 agents in the articles were implicated in the PI3K/AKT and/or Hippo pathways, most of which target the PI3K/AKT pathway. It can be concluded that controlling both the PI3K/AKT and Hippo pathways, but specifically the PI3K/AKT pathway, can help maintain ovarian reserve against these two chemotherapy drugs and provide hope for increased fertility in patients receiving chemotherapy.</p>","PeriodicalId":22046,"journal":{"name":"Supportive Care in Cancer","volume":"33 4","pages":"328"},"PeriodicalIF":2.8,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143735685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Physiotherapy protocol to reduce the evolution time of axillary web syndrome in women post-breast cancer surgery: a randomized clinical trial.","authors":"Jesús Baltasar González-Rubino, Rocío Martín-Valero, María Jesús Vinolo-Gil","doi":"10.1007/s00520-025-09373-1","DOIUrl":"10.1007/s00520-025-09373-1","url":null,"abstract":"<p><strong>Objective: </strong>To reduce the evolution time of axillary web syndrome in women who have undergone breast cancer surgery.</p><p><strong>Methods: </strong>A prospective, randomized, single-blind clinical trial was conducted on 46 post breast cancer surgery patients from October 2021 to September 2024, in a single university hospital with painful Axillary Web Syndrome (AWS) that restricts arm mobility. The treatment for the intervention group consisted of stretching combined with manual therapy and scar massage to release adhesion and lymphatic cord during 15 physiotherapy sessions of 30 min duration each. The main outcome measures were: healing time, pain, evaluated with Visual Analogue Scaler (VAS) and arm Range of Motion (ROM), evaluated with goniometry.</p><p><strong>Results: </strong>Significant differences were detected in pain and in ROM. The effect of the intervention varied over time with 95% confidence interval (risk alpha 0.05) and a statistical power of 90% (risk beta 0.1). Comparisons between Control and Intervention Groups showed significant statistical and clinical differences in favour of Intervention Group after 30, 60 and 90 days of intervention at follow-ups for all measured parameters. The proportion of healed patients was significantly higher in the intervention group from day 30 onwards (two-sample test for equality of proportions: p < 0.001), indicating a faster recovery in the intervention group.</p><p><strong>Conclusion: </strong>The results suggested that stretching combined with scar massage and manipulative tissue release techniques lead to a faster recovery and reduce the evolution time of axillary web syndrome. The physiotherapy technique described in this article could be the technique of choice for this surgical sequela.</p><p><strong>Trial registration: </strong>ClinicalTrials.gov Registry (NCT05115799) on June 10th 2021 and the approval of the Andalucía Ethics Committee (PEIBA code 1909-N1-21, reg. number 171.21).</p>","PeriodicalId":22046,"journal":{"name":"Supportive Care in Cancer","volume":"33 4","pages":"326"},"PeriodicalIF":2.8,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11953149/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143736219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The holistic model of leukaemia survivorship care: derived from a qualitative exploration of leukaemia survivorship.","authors":"S Kirsten, R Laidsaar-Powell, J M Shaw, H M Dhillon","doi":"10.1007/s00520-025-09382-0","DOIUrl":"10.1007/s00520-025-09382-0","url":null,"abstract":"<p><strong>Purpose: </strong>Increasing survival rates have left many leukaemia survivors with debilitating effects from the disease and its treatments. However, little is known about the persistent unmet needs of people living with leukaemia.</p><p><strong>Methods: </strong>We aimed to qualitatively explore the experiences of individuals living with leukaemia and suitability of the Clinical Oncology Society of Australia's (COSA) Model of Survivorship Care (2016) to reflect leukaemia survivorship. We used an inductive qualitative approach, conducting semi-structured interviews with leukaemia survivors recruited via social media and cancer advocacy organisations. Interviews were continued until information power was deemed appropriate. Reflexive thematic analysis (RTA) was used to describe and interpret key themes and meta-themes in the data.</p><p><strong>Results: </strong>Overall findings were examined alongside the COSA Model. Twenty-four leukaemia survivors were interviewed; six themes were identified: (1) leukaemia is impactful, life-altering, and unexpected; (2) leukaemia is enduring, life-limiting, and uncertain; (3) survivorship is a team effort; (4) centrality of work as identity, focus, and financial security; (5) the dynamic landscape of coping; and (6) survivorship as adjusting. Overall, participants described leukaemia survivorship as (1) recursive and (2) holistic.</p><p><strong>Conclusions: </strong>Our findings, while broadly corresponding with the COSA Model, demonstrate it lacks nuances specific to leukaemia survivorship. We recommended the HMLS be used to guide future leukaemia-specific development of the COSA Model and survivorship services.</p><p><strong>Implications for cancer survivors: </strong>We identified key domains and stages common across leukaemia survivorship, presented in our proposed Holistic Model of Leukaemia Survivorship (HMLS), addressing these domains are critical to the provision of quality survivorship care.</p>","PeriodicalId":22046,"journal":{"name":"Supportive Care in Cancer","volume":"33 4","pages":"327"},"PeriodicalIF":2.8,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11953203/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143735702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}