Supportive Care in Cancer最新文献

{"title":"Mandala painting therapy applied to cancer patient: a scoping review.","authors":"Yue Chen, Yingping Fu, Xin Guo, Xiaoyan Mu, Yinglan Duan, Juli Shen","doi":"10.1007/s00520-025-09884-x","DOIUrl":"10.1007/s00520-025-09884-x","url":null,"abstract":"<p><strong>Purpose: </strong>Psychological care has been shown to effectively enhance the quality of life for cancer patients and reduce negative emotions such as anxiety and depression. Recently, mandala drawing therapy has emerged as a novel approach to assist cancer patients in managing their psychological challenges. Nevertheless, the application of this therapy lacks scientific guidelines, and inconsistencies persist across related studies. Therefore, this study aims to synthesize and scrutinize the existing research on the utilization of mandala drawing therapy for cancer patients, striving to establish a scientific framework for its widespread clinical implementation in the future and serving as a valuable resource for further research.</p><p><strong>Methods: </strong>A scoping review was conducted to delve deeper into the existing evidence and identify knowledge gaps relevant to future research efforts. Utilizing the Joanna Briggs Institute's methodology for systematic reviews, we conducted searches in PubMed, Web of Science, Cochrane Library, CINAHL, Embase, Wanfang, CNKI, VIP Information Services Platform, and China Biomedical Literature Service System, covering the entire duration from the establishment of each database up to December 2023.</p><p><strong>Results: </strong>The search strategy yielded 335 studies, of which 11 met the study criteria after screening. The findings indicated that mandala painting therapy effectively improved the quality of life and satisfaction with care among cancer patients while alleviating negative emotions. However, the treatment did not significantly affect pain levels and the fear of recurrence in these patients.</p><p><strong>Conclusion: </strong>Mandala painting therapy primarily functions as a psychotherapeutic and psychological assessment tool. Although it has shown positive effects on cancer patients, further exploration is needed regarding its implementation methods. Future research should consider expanding the sample size and making more substantial efforts to investigate the therapy's effects in depth.</p><p><strong>Trial registration: </strong>OSF registration DOI: https://doi.org/10.17605/OSF.IO/EZNMX.</p>","PeriodicalId":22046,"journal":{"name":"Supportive Care in Cancer","volume":"33 10","pages":"875"},"PeriodicalIF":3.0,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12460571/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145131673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effects of early rehabilitation on physical and psychosocial functions after breast cancer surgery.","authors":"Atiye Kaş Özdemi̇r, Orçin Telli Atalay, Sevda Yılmaz, Hande Şenol","doi":"10.1007/s00520-025-09926-4","DOIUrl":"10.1007/s00520-025-09926-4","url":null,"abstract":"<p><strong>Purpose: </strong>The aim of this study was to examine the short-term effects of early rehabilitation on physical and psychosocial functions in individuals undergoing breast cancer surgery.</p><p><strong>Methods: </strong>Sixty-three female patients with breast cancer who were scheduled for surgery were randomly divided into three groups using the closed envelope method. Participants in Group 1 (G1) received preoperative patient education, exercised under the supervision of a physiotherapist during postoperative hospitalization, received a patient information brochure, and were followed up for 3 months after surgery with telephone calls at 2-week intervals. Participants in Group 2 (G2) received preoperative patient information and a patient information brochure. Participants in Group 3 (G3) received only preoperative patient information. Upper extremity circumference measurements, tissue dielectric constant measurements, shoulder Function, quality of life, and fatigue level assessments were repeated preoperatively, at postoperative discharge, and 3 months after surgery.</p><p><strong>Results: </strong>The limb volumes of all the groups increased over time (p < 0.05; except the volume of the unaffected limb in G2). The volume difference between the extremities increased over time only in G2 (p < 0.05). The subdermal fluid ratios of all the groups increased after surgery but decreased after 3 months. The modified Constant-Murley score, which reflects shoulder Function, decreased in all groups after surgery and was similar to the baseline value after 3 months, except G3, in which the score was significantly lower than the baseline value (p < 0.05).</p><p><strong>Conclusions: </strong>The results of this study revealed that the physical and psychosocial functions of individuals deteriorate after breast cancer surgery, but early physiotherapist follow-up is effective in maintaining these functions and preventing breast cancer-related lymphedema.</p><p><strong>Trial registration: </strong>NCT04979715 (27/07/2021).</p>","PeriodicalId":22046,"journal":{"name":"Supportive Care in Cancer","volume":"33 10","pages":"872"},"PeriodicalIF":3.0,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145131679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of acupuncture in managing radiotherapy/chemotherapy-induced oral mucositis: a systematic review and meta-analysis.","authors":"Lei Ji, Lin Han, Aabha Sharma","doi":"10.1007/s00520-025-09931-7","DOIUrl":"10.1007/s00520-025-09931-7","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the preventive and therapeutic efficacy of acupuncture modalities in radiation/chemotherapy-induced oral mucositis (RIOM/CIOM) management through evidence synthesis.</p><p><strong>Methods: </strong>A systematic search was performed in eight biomedical databases: four English-language databases (PubMed, Embase, Web of Science, and Cochrane Library) and four Chinese-language databases (China National Knowledge Infrastructure (CNKI), Wanfang, VIP, and SinoMed) for studies published up to July 25, 2025. Randomized controlled trials (RCTs) in English or Chinese investigating acupuncture for RIOM/CIOM were included. Dual independent extraction with standardized forms and quality appraisal using the Cochrane RoB 2.0 tool were implemented. The primary outcome was OM grading according to WHO, RTOG, or other recognized scales. The evidence quality was assessed using the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) methodology.</p><p><strong>Results: </strong>Eleven RCTs (n = 865) were included. Acupuncture significantly reduced moderate-to-severe OM incidence [RR = 0.58, 95% CI:0.45-0.76; P < 0.0001), with therapeutic interventions showing greater efficacy than preventive approaches (P < 0.0001). Auricular acupuncture showed substantial benefit (RR = 0.54 vs manual technique RR = 0.97). Other outcomes revealed significant ulcer duration reduction (SMD = -1.13, 95% CI -1.71-[-0.55]; P = 0.0001), pain score improvement (SMD = -1.89, P = 0.0005), and enhanced immune modulation (TGF-β1/IL-6 levels) with Karnofsky performance increase (MD = 5.83, P = 0.004). No severe adverse events were reported. The quality of evidence was rated as moderate due to significant heterogeneity observed across the studies.</p><p><strong>Conclusions: </strong>The systematic review and meta-analysis found that acupuncture was effectively associated with preventing and treating RIOM/CIOM, shortening ulcer duration, reducing ulcer size, alleviating pain, and improving quality of life, although the evidence level was moderate. The finding suggests that more high-quality RCTs were needed for validation.</p>","PeriodicalId":22046,"journal":{"name":"Supportive Care in Cancer","volume":"33 10","pages":"873"},"PeriodicalIF":3.0,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145131740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fatigue of Cancer is Distinctly Different than the Fatigue of Chronic Kidney Disease.","authors":"Carlos Fernandez, Alexander R Chang, Erin VanEnkevort, Mellar P Davis","doi":"10.1007/s00520-025-09941-5","DOIUrl":"10.1007/s00520-025-09941-5","url":null,"abstract":"<p><strong>Introduction: </strong>It remains unclear whether the mechanisms of fatigue in cancer and chronic kidney disease (CKD) are different. The assessment of self-reported fatigue by standard scales, muscle fatigue by the objective reduction in finger tapping speed, and the cost to the brain of the exercise by the rating of perceived effort (RPE) help to compare the phenotypes of fatigue between the two conditions and explore the mechanisms of fatigue.</p><p><strong>Methods: </strong>We initially assessed the correlations between fatigue, measured by the Brief Fatigue Inventory (BFI); muscle fatigue (measured by the finger tapping speed) and RPE in 30 patients with cancer and subsequently 30 patients with stage 3B-5 CKD. Exclusion criteria for both groups included movement disorders, history of stroke, and depression. Other exclusions for patients with CKD were ejection fraction < 40%, history of cancer, hemoglobin < 10 g/dL, and recent hospitalization. The Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT-F) scale was also assessed for CKD patients.</p><p><strong>Results: </strong>In cancer patients, fatigue showed no correlation with muscle fatigue but had a strong correlation with RPE (r = 0.75, p < 0.01). Conversely, in CKD patients, fatigue did not correlate with RPE but was significantly correlated with muscle fatigue at the 30-s tapping interval (r = 0.68, p < 0.01). Additionally, BFI scores were highly correlated with FACIT-F scores in CKD patients (r = 0.89, p < 0.001).</p><p><strong>Conclusions: </strong>Cancer-related fatigue differs from CKD-related fatigue, based on a protocol that includes the assessment of subjective fatigue, muscle fatigue by the finger tapping speed, and RPE. Whereas cancer-related fatigue correlates with higher perceived effort, CKD-related fatigue correlates with reduced motor performance. These findings support the use of condition-specific fatigue assessments and highlight the value of integrating both subjective and objective measures in the understanding of fatigue.</p>","PeriodicalId":22046,"journal":{"name":"Supportive Care in Cancer","volume":"33 10","pages":"870"},"PeriodicalIF":3.0,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145126069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sexual health in older adults with hematologic malignancies - a sub-analysis of a Danish cross-sectional study.","authors":"Melissa Street Chamberlin, Andrea Lange, Mary Jarden, Kristina Holmegaard Nørskov","doi":"10.1007/s00520-025-09921-9","DOIUrl":"10.1007/s00520-025-09921-9","url":null,"abstract":"<p><strong>Purpose: </strong>This study aims to emphasize the importance of sexual health in older adults with hematologic malignancy (HM) in Denmark by exploring the prevalence of sexual symptoms and factors that influence sexual activity and function.</p><p><strong>Methods: </strong>A sub-analysis of a Danish cross-sectional study including older adults (≥ 65 years) diagnosed with a HM from 20/1-2013 to 20/8-2022. Eligible participants received electronic validated questionnaires about quality of life, sexuality, and sexual health in their officially assigned digital mailbox.</p><p><strong>Results: </strong>Decreased libido, impaired sexual activity, diminished confidence in erection, vaginal dryness, and reduced sexual satisfaction were among the most reported sexual symptoms. Interestingly, 93% of participants reported that sexual health had never been discussed with healthcare professionals. A significant correlation was found between sexual inactivity and a higher degree of sexual dysfunction in both men and women. Gender comparison revealed that men experienced significantly more sexual distress than women (p = 0.012). Age stratification showed that men aged 65-75 had significantly better erectile function compared to those > 75 (p = 0.031), while women aged 65-75 had better sexual arousal and orgasmic function than those > 75 years (p = 0.028).</p><p><strong>Conclusion: </strong>Older adults with HM experience a high prevalence of sexual dysfunction. Men > 75 years experienced more severe erectile dysfunction, and sexual distress was particularly notable among men and patients with lymphoma. Regardless of treatment, sexual dysfunction persists in older adults with HM, emphasizing the need for continuous, supportive care addressing sexual health both during and after treatment.</p>","PeriodicalId":22046,"journal":{"name":"Supportive Care in Cancer","volume":"33 10","pages":"871"},"PeriodicalIF":3.0,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12457468/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145126063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Women's adherence to medication and hope in the presence of another chronic disease besides breast cancer: a cross-sectional study.","authors":"Figen Akay, Ayşe Özkaraman, Öznur Bal","doi":"10.1007/s00520-025-09939-z","DOIUrl":"10.1007/s00520-025-09939-z","url":null,"abstract":"<p><strong>Purpose: </strong>This study was conducted to evaluate the level of hope and adherence to medication in women with breast cancer in the presence of another chronic disease.</p><p><strong>Methods: </strong>The cross-sectional study was conducted in March-August 2022 with women with breast cancer with (CVD group) and without (Non-CVD group) cardiovascular disease as a chronic disease. Data were collected with the 'Individual Information Form', 'Herth Hope Scale' and 'Medication Adherence and Prescription Writing Scale'. Independent Sample T-test, Mann Whitney U Test, Chi-Square Test and Correlation Analysis were used to analyze the data.</p><p><strong>Results: </strong>Adherence to medication levels of the patients were higher with a mean score of 8.55 ± 2.16 in the CVD group and 8.33 ± 2.14 in the Non-CVD group and there was no difference between the two groups (p < 0.05). When the hope levels of the patients were evaluated; the hope level of the CVD group was 69.57 ± 9.58 and the hope level of the Non-CVD group was 74.96 ± 7.98. The hope level of the CVD group was lower than that of the Non-CVD group (p < 0.001, Cohen's d = 0.61).</p><p><strong>Conclusion: </strong>In women, the presence of a chronic (cardiovascular) disease in addition to breast cancer does not affect medication adherence but negatively affects the level of hope.</p>","PeriodicalId":22046,"journal":{"name":"Supportive Care in Cancer","volume":"33 10","pages":"869"},"PeriodicalIF":3.0,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145114034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Handgrip strength assessment in breast cancer patients: validity and reliability of the Activ5 dynamometer.","authors":"José Pino-Ortega, Rafael Carvajal-Espinoza, Boryi Becerra-Patiño, Aaron Gómez-Parra, Adrián Moreno-Villanueva","doi":"10.1007/s00520-025-09895-8","DOIUrl":"10.1007/s00520-025-09895-8","url":null,"abstract":"<p><p>Hand dynamometry is a widely accepted method for measuring muscle strength and serves as a crucial clinical indicator, particularly in populations with chronic health conditions, such as cancer. Despite its growing use, no prior study has evaluated the validity of the Activ5 portable dynamometer in individuals with cancer. This study aimed to determine the reliability and validity of the Activ5 for assessing handgrip strength (HGS) in a population of female cancer survivors. The sample consisted of 22 women (mean age 53.91 ± 5.93 years; body mass 65.85 ± 14.52 kg; height 1.65 ± 0.04 m), who were assessed across two testing sessions in a cross-sectional concordance design. Reliability and validity were analyzed using Pearson correlation coefficients, intraclass correlation coefficients (ICC), and Lin's concordance coefficient. Results demonstrated very strong correlations between the Activ5 and the gold-standard Jamar dynamometer. For the right hand, r = 0.895 (p = 0.001), and for the left hand, r = 0.893 (p = 0.001). Lin's ICC for the right hand was 0.995 (95% CI: 0.974-1.016), and for the left hand 0.990 (95% CI: 0.959-1.020). These findings indicate excellent agreement and support the use of the Activ5 as a valid and reliable tool for evaluating HGS in cancer survivors. Its portability and ease of use make it a practical option for both clinical and research settings.</p>","PeriodicalId":22046,"journal":{"name":"Supportive Care in Cancer","volume":"33 10","pages":"866"},"PeriodicalIF":3.0,"publicationDate":"2025-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12450119/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145092558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oral health-related quality of life among long-term head and neck cancer survivors: a multinational study.","authors":"Kristine Løken Westgaard, Cecilie Delphin Amdal, Katherine J Taylor, Ragnhild Sørum Falk, Kristin Bjordal, Susanne Singer, Eva Hammerlid, Max Krüger, Carmen Stromberger, Orlando Guntinas-Lichius, Fréderic Duprez, Noa Stempler, Noam Yarom, Erofili Papadopoulou, Bente Brokstad Herlofson","doi":"10.1007/s00520-025-09930-8","DOIUrl":"10.1007/s00520-025-09930-8","url":null,"abstract":"<p><strong>Purpose: </strong>Our aim was to investigate oral health-related quality of life (OHRQoL) and toxicities in long-term head and neck cancer (HNC) survivors diagnosed ≥five years earlier.</p><p><strong>Methods: </strong>HNC survivors treated between 2007 and 2013 participated in an international cross-sectional study. They completed the European Organization for Research and Treatment of Cancer (EORTC) core quality of life questionnaire (EORTC QLQ-C30) and the oral health module (EORTC QLQ-OH15) and attended a hospital examination. Clinicians scored toxicities using the Common Terminology Criteria for Adverse Events version 5.0. OHRQoL was analyzed based on four types of treatment: surgery, radiotherapy, chemoradiotherapy without surgery and surgery with postoperative (chemo) radiotherapy. Survivors were divided into three groups according to the EORTC QLQ-OH15 oral health-QoL scale score; the lowest (defined as poor OHRQoL), middle and highest tertile.</p><p><strong>Results: </strong>Eleven sites in six countries enrolled 404 HNC survivors. The median time since diagnosis was 8.4 years, the mean age was 66 years and 67% were male. A total of 116 (29%) of the survivors reported poor OHRQoL. They were more often females and survivors with advanced disease. The survivors with poor OHRQoL also had more toxicity: dysphagia, trismus, osteonecrosis of the jaw, oral pain and dry mouth. There were no clinically significant differences in OHRQoL between the four treatment groups.</p><p><strong>Conclusion: </strong>Our study showed that the survivors who reported poor OHRQoL also had a high level of late toxicity. This highlight the need for improved follow-up of the oral health of HNC survivors many years after initial treatment, especially for women and those who were treated for advanced disease.</p>","PeriodicalId":22046,"journal":{"name":"Supportive Care in Cancer","volume":"33 10","pages":"868"},"PeriodicalIF":3.0,"publicationDate":"2025-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12450221/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145102921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of oncology review meetings on second opinions for patients with gastrointestinal cancer.","authors":"Marc Nourrit, Géraldine M Camilleri, Anne-Claire Couderc, Audrey Verchain, Kamilia Bouatay, Marine Valéry, Cristina Smolenschi, Antoine Hollebecque, Thomas Pudlarz, Alexandre Megherbi, Laura Diebakate, Matthieu Delaye, Mohamed Khettab, Valérie Boige, Michel Ducreux, Alice Boilève","doi":"10.1007/s00520-025-09922-8","DOIUrl":"10.1007/s00520-025-09922-8","url":null,"abstract":"<p><strong>Purpose: </strong>Second opinions are increasingly sought by patients, particularly in complex and life-altering conditions such as gastrointestinal (GI) cancers, to ensure confidence in their diagnosis and treatment plans or to seek therapeutic trials.</p><p><strong>Methods: </strong>This retrospective study analyzed second-opinion requests handled by the GI oncology team in our institution between January and March 2024, examining the types of questions raised, patient characteristics, and their impact on clinical decision-making.</p><p><strong>Results: </strong>Of 261 eligible patients, 259 were included in this analysis. Most patients had metastatic disease (86%), and 51% had received at least two lines of prior treatment. Requests were predominantly submitted by oncologists (63%), with a significant proportion (41%) coming from outside academic centers. General practitioners (GPs) accounted for 37% of the submissions, often with incomplete records (86% completeness vs. 99% for oncologists; p < 0.01). The median age at diagnosis was 60 years, with younger patients being more frequently referred by oncologists (57.0 vs. 62.5 years, p < 0.001). The most common diagnoses were pancreatic (29%) and colorectal (27%) cancers. Second-opinion requests focused on therapeutic management (73%) and access to clinical trials (60%). Therapeutic decisions were in line with the standard of care in 93% of the cases, while 15% received alternative recommendations, such as intrahepatic arterial infusion or targeted therapies. However, participation in therapeutic trials (1.2%) and molecular screening (2.7%) was seldom offered to patients, highlighting the need for better tools to access trials. Importantly, palliative care decisions were upheld in 95% of the specific requests.</p><p><strong>Conclusion: </strong>This study demonstrates the potential value of structured second-opinion pathways in ensuring adherence to evidence-based care and addressing patient concerns. However, improving GP support, reducing referral delays, and optimizing access to trials remain critical for improving outcomes in patients with advanced GI cancer.</p>","PeriodicalId":22046,"journal":{"name":"Supportive Care in Cancer","volume":"33 10","pages":"867"},"PeriodicalIF":3.0,"publicationDate":"2025-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145092526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enteral versus parenteral nutrition in auto-HCT: a randomized controlled trial on clinical outcomes and gut microbiome dynamics.","authors":"Hannah R Wardill, Lenneke F J van Groningen, Mohsen Dorraki, Eva B D Molendijk, Doris Kalter, Ana Rita Da Silva Ferreira, Alexander Kurilshikov, Feargal J Ryan, Johan W Verjans, Hermie J M Harmsen, Wim J E Tissing, Walter J F M van der Velden, Nicole M A Blijlevens","doi":"10.1007/s00520-025-09882-z","DOIUrl":"10.1007/s00520-025-09882-z","url":null,"abstract":"<p><p>Disruption of the gut microbiome is a common consequence of chemotherapy, linked with detrimental treatment outcomes (e.g. sepsis), especially in haematopoietic stem cell transplant (HCT) recipients. Preclinical data suggest that enteral nutrition (EN) is superior to parenteral nutrition (TPN), minimising gut atrophy and promoting eubiosis; yet, TPN continues to be used. Here, we evaluated the clinical effects of EN and TPN in autologous HCT recipients and their influence on gut microbiome dynamics. Despite efforts to optimise delivery, EN was poorly tolerated and ultimately proved unfeasible. As such, we turned our attention to analysing microbial dynamics in our study cohort and confirmed preclinical reports that epithelial apoptosis drives gut microbiome disruption. Machine learning models predicted microbial composition by tracking plasma citrulline trajectories, a biomarker of enterocyte mass. These findings suggest that (i) monitoring citrulline may be able to identify patients at risk of potentially lethal HCT complications associated with gut microbiome disruption, and that (ii) preserving epithelial integrity could support microbial resilience by minimising the production of caspase-dependent metabolites. Dutch Trial Register: NL4069. Data registered: 19-11-2013. www.trialregister.nl.</p>","PeriodicalId":22046,"journal":{"name":"Supportive Care in Cancer","volume":"33 10","pages":"865"},"PeriodicalIF":3.0,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12449397/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145087289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}