Supportive Care in Cancer最新文献

{"title":"Effectiveness of an online mindfulness-based stress-reduction intervention to reduce anxiety in breast cancer survivors: a randomized-controlled trial.","authors":"Ana Ferrigno Guajardo, Misael Salazar-Alejo, Fernanda Mesa-Chavez, Javier Gutierrez-Ornelas, Alejandra Platas, Haydee Verduzco-Aguirre, Cynthia Villarreal-Garza","doi":"10.1007/s00520-025-09681-6","DOIUrl":"10.1007/s00520-025-09681-6","url":null,"abstract":"<p><strong>Purpose: </strong>This study evaluated the efficacy of an online mindfulness-based stress reduction (MBSR) intervention in reducing anxiety among breast cancer (BC) survivors, leveraging the potential advantages of digital delivery to enhance psychosocial care for this population.</p><p><strong>Methods: </strong>In this randomized controlled trial, 68 BC survivors with elevated anxiety levels were assigned to either an 8-week online MBSR intervention (n = 33) or a waitlist control group (n = 35). Anxiety (GAD-7), depression (PHQ-9), fatigue (FACIT-F), insomnia (ISI), cancer-related worry (CWS), vasomotor symptoms (MENQOL), and mindful awareness (MAAS) were assessed at baseline, post-intervention, and at 5- and 8-months follow-up.</p><p><strong>Results: </strong>Compared to the control group, MBSR participants showed significant reductions in anxiety (mean difference -4.13 points, 95CI -6.79 to -1.46, p = 0.003), depression (mean score difference -6.03, p < 0.001), fatigue (mean difference + 6.03, p = 0.002), insomnia (mean difference -3.97, p = 0.026), and cancer-related worry (mean difference -4.57, p = 0.003) at post-intervention, but no change in vasomotor symptoms (p > 0.05). MBSR participants also demonstrated increased mindful awareness (mean difference + 1.00, p = 0.004) that persisted through follow-up. The proportion of participants with clinically significant anxiety decreased from 96% pre-intervention to 38% at 8-months follow-up in the MBSR group, compared to relatively stable rates (88% to 87%) in the control group.</p><p><strong>Conclusions: </strong>Online MBSR is a potentially effective intervention for reducing anxiety and improving psychological well-being in BC survivors. This accessible format may help overcome barriers to psychosocial care for cancer survivors.</p><p><strong>Clinicaltrials: </strong></p><p><strong>Gov id: </strong>NCT05837169.</p>","PeriodicalId":22046,"journal":{"name":"Supportive Care in Cancer","volume":"33 7","pages":"623"},"PeriodicalIF":2.8,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144485795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A qualitative study on rumination in young and middle-aged ovarian cancer survivors.","authors":"Guifen Wang, Qiao Zhou, Meijun Ou","doi":"10.1007/s00520-025-09677-2","DOIUrl":"10.1007/s00520-025-09677-2","url":null,"abstract":"<p><strong>Purpose: </strong>Ovarian cancer can have a significant psychological impact on young and middle-aged patients who are often prone to recurring changes in mood that can lead to rumination. This phenomenological qualitative study aimed to explore rumination in young and middle-aged ovarian cancer survivors.</p><p><strong>Methods: </strong>From August to November 2023, 21 young and middle-aged ovarian cancer survivors who were treated at a tertiary general hospital in Changsha, Hunan Province, China were selected using purposive sampling. In-depth semi-structured interviews were conducted using phenomenological research methods; interview data were analyzed according to the Colaizzi 7-step analysis method.</p><p><strong>Results: </strong>Rumination among young and middle-aged ovarian cancer survivors was summarized into four themes and 12 subthemes: uncontrollable response (unstoppable depression, sustained concerns, psychosomatic symptoms), persistent frustration (stigma, consciousness of self-guilt, social avoidance), recurring anxiety (anxiety about death, cancer recurrence, loss of function), and adaptive adjustment (distancing from emotional black holes, clarifying the value of life, and engaging in meaningful action).</p><p><strong>Conclusion: </strong>Rumination is common among young and middle-aged ovarian cancer survivors. They experience uncontrollable responses, persistent frustration, recurring anxiety, and adaptive adjustment. These results can provide a reference for healthcare professionals to develop targeted intervention strategies.</p><p><strong>Implications: </strong>This study revealed the content and experiences of rumination among young and middle-aged ovarian cancer survivors, providing theoretical support for intervention development. Mindfulness-based therapies may be useful in helping patients strengthen their psychological coping, and combining social resources to provide patients with comprehensive support may help reduce their negative emotions and improve quality of life.</p>","PeriodicalId":22046,"journal":{"name":"Supportive Care in Cancer","volume":"33 7","pages":"618"},"PeriodicalIF":2.8,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12187878/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144476716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Knowledge, attitude, and practices in febrile neutropenia among nurses at a tertiary care cancer center in rural India.","authors":"Vineetha Raghavan, Abhilash Menon, Nandini Devi R, Sajitha P, Praveen Kumar Shenoy, Jithin T K, Gopakumar K G, Ratheesan K, Chandran K Nair","doi":"10.1007/s00520-025-09679-0","DOIUrl":"10.1007/s00520-025-09679-0","url":null,"abstract":"<p><strong>Purpose: </strong>Febrile neutropenia (FN) is a major cause of morbidity and mortality in chemotherapy patients. Nurses play a vital role in FN management, yet studies assessing their knowledge, attitude, and practices (KAP) in India are limited. This study aimed to evaluate KAP among nurses in a rural Indian tertiary cancer center.</p><p><strong>Methodology: </strong>This cross-sectional KAP survey involved 111 staff nurses at a tertiary cancer center in rural India from October to November 2022. A validated questionnaire with 17 multiple-choice questions (five knowledge, five attitude, seven practice) was used. Demographic and professional details were collected.</p><p><strong>Results: </strong>Among 111 participants, 86.4% were female, and 55% had over 10 years of experience. Most (93%) had administered chemotherapy, and 78% had cared for FN patients. The median knowledge score was 4 (range 1-7), with an 80.36% prevalence. Only 61% correctly calculated the absolute neutrophil count. Better scores were seen among permanent staff, those who had attended FN classes, and those with prior FN care experience. The median attitude score was 5 (range 2-7), with a 90.09% prevalence of positive attitude. Nurses with prior chemotherapy administration experience and FN care experience had better scores.The median practice score was 6 (range 1-7), with a 78.42% prevalence. A key gap was identified, as 77% answered incorrectly regarding blood culture sampling during FN episodes. Nurses who attended FN educational classes scored better.</p><p><strong>Conclusion: </strong>Although nurses' knowledge and attitudes were found to be satisfactory, there are noticeable gaps in their practice, especially when it comes to blood culture sampling, which suggests that focused educational programs are necessary. Improving FN management results requires strengthening practical skills through training, simulations, and protocol reinforcement.</p>","PeriodicalId":22046,"journal":{"name":"Supportive Care in Cancer","volume":"33 7","pages":"617"},"PeriodicalIF":2.8,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144476721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of long-term alopecia after adjuvant taxane therapy for early breast cancer: a cross-sectional survey.","authors":"Amy E Smith, Michelle Harrison, Catriona McNeil, Jane Beith, Jennifer Lim","doi":"10.1007/s00520-025-09664-7","DOIUrl":"10.1007/s00520-025-09664-7","url":null,"abstract":"<p><strong>Background: </strong>Alopecia is a distressing side-effect of taxane chemotherapy, and evidence suggests that docetaxel leads to chronic alopecia. We measured rates of satisfaction with hair regrowth among women who received adjuvant docetaxel compared with paclitaxel to identify a difference in outcomes.</p><p><strong>Methods: </strong>We identified adult female patients who received paclitaxel or docetaxel chemotherapy for early breast cancer from 2010 to 2015. They were screened to ensure they were alive, without metastatic relapse or a new cancer. Eligible participants were sent an introductory letter, consent, a Dermatology Life Quality Index (DLQI) questionnaire, a Visual Analogue Score (VAS) and the European Organisation for Research and Treatment of Cancer (EORTC) general and breast-specific quality of life. The primary outcomes were the DLQI: a 10-item questionnaire scored on a 0-3 scale (higher scores indicating distress and dissatisfaction) and the VAS (scored out of 4). Secondary outcomes were the global health status, function, symptom score and breast specific outcomes shown by the EORTC QLQ-C30 and EORTC QLQ-BR23.</p><p><strong>Results: </strong>There were 88 responders from 210 letters (response rate 42%); 38 (43%) had docetaxel and 50 (57%) had paclitaxel. They were aged 26-90 (median: 59). There was a significant difference in DLQI scores, with the docetaxel group having a higher median score (docetaxel: 4 vs paclitaxel: 1, p = 0.01). A significantly higher proportion of patients reported no effect of hair loss in the paclitaxel group (p = 0.02). Similarly, there was a significant difference in VAS scores with the docetaxel group having a higher median score (docetaxel: 1 vs. paclitaxel: 0.5, p = 0.002). Secondary outcomes did not reach statistical significance. There was no association with aromatase inhibitor exposure.</p><p><strong>Conclusions: </strong>Our study shows that adjuvant docetaxel chemotherapy is associated with statistically significant higher rates of dissatisfaction and chronic alopecia than paclitaxel chemotherapy. This supports literature and should be discussed prior to administering docetaxel regimens.</p>","PeriodicalId":22046,"journal":{"name":"Supportive Care in Cancer","volume":"33 7","pages":"615"},"PeriodicalIF":2.8,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12185643/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144476717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The supportive oncology landscape: current status.","authors":"Ye M Aung, Jake Waldman, Jacquelyn Jackson, Robert A O'Connor, Beth York, Declan Walsh","doi":"10.1007/s00520-025-09626-z","DOIUrl":"10.1007/s00520-025-09626-z","url":null,"abstract":"<p><strong>Purpose: </strong>Cancer care has changed dramatically in the past decade, with novel treatments and longer life expectancy. Despite these advancements, many people with cancer experience significant disease and treatment-related morbidity and mortality. The term \"supportive oncology\" has been proposed to define various services (nutrition counseling, palliative medicine, psychology, etc.) to support individuals throughout the cancer-care continuum. Though these services are vital, their availability, implementation, and organization are inconsistent and ill-defined.</p><p><strong>Methods: </strong>We did a Google™ search to identify the availability of sixteen empirically determined supportive oncology services. Four distinct searches were performed sequentially with the terms, 1.) \"supportive oncology programs\", 2.) \"supportive oncology departments\", 3.) \"cancer care support\", and 4.) \"cancer support programs.\" Results were filtered through ten further criteria. Descriptive language regarding service organization and leadership structure was reviewed.</p><p><strong>Results: </strong>All four searches in combination yielded 88 cancer care entities (CCE). Then, 32 (36%) were designated by the National Cancer Institute as a Comprehensive Cancer Center (NCI-CCC). Of all CCE, the most frequent service provided was support groups (76/88, 86%), and least often geriatric oncology (18/88, 21%). NCI-CCC offered a greater scope and scale of services than non-designated centers. Then, 45 (51%) CCE referred to these offerings as \"services\" but only 8 (9%) were organized as a formal department.</p><p><strong>Conclusions: </strong>Heterogeneity exists in the types of supportive services provided by CCE. The predominant informal organization of supportive oncology services is notable and unsatisfactory. To improve comprehensive cancer care, there is a compelling need for organizations like the NCI, American Society of Clinical Oncology, and the Commission on Cancer to develop formal standards for supportive oncology services.</p>","PeriodicalId":22046,"journal":{"name":"Supportive Care in Cancer","volume":"33 7","pages":"611"},"PeriodicalIF":2.8,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144476764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to: \"Caregiver experiences managing information prior to hematopoietic stem cell transplantation and after transition to home: a qualitative study\".","authors":"Kohei Kajiwara, Jun Kako, Masamitsu Kobayashi, Yasuhide Etou, Teppei Yamashita, Makoto Yamanaka, Maki Kanaoka","doi":"10.1007/s00520-025-09684-3","DOIUrl":"10.1007/s00520-025-09684-3","url":null,"abstract":"","PeriodicalId":22046,"journal":{"name":"Supportive Care in Cancer","volume":"33 7","pages":"616"},"PeriodicalIF":2.8,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144476761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differences in travel burden between patients with self-reported curable and incurable cancer: results from a Dutch flash mob study.","authors":"M A J Versluis, E C S de Boer, L V van de Poll-Franse, N J H Raijmakers, P A J Vissers, I H Dingemans, M B de Ruiter, M Slingerland, A K L Reyners, M E T Tesselaar, A N M Wymenga","doi":"10.1007/s00520-025-09675-4","DOIUrl":"10.1007/s00520-025-09675-4","url":null,"abstract":"<p><strong>Purpose: </strong>To explore travel burden in patients with self-reported curable and incurable cancer.</p><p><strong>Method: </strong>A 2-day flash mob study was conducted in March 2023 among patients visiting medical oncology departments in 65 Dutch hospitals. Disease status was self-reported. Patients completed a questionnaire on travel time (one-way), travel problems, and willingness to travel. Descriptive analyses and logistic regression analyses were used to assess travel burden and its associated factors.</p><p><strong>Results: </strong>In total, 991 patients with curable and 1959 with incurable cancer were included. Patients with curable cancer more often reported daily or weekly hospital visits (63% vs. 22%, p < 0.001) and a travel time of less than 30 min (78% vs. 73%, p = 0.005). Almost one-third of patients with curable (28%) and incurable cancer (29%) experienced some travel problems. Patients with worse physical functioning and longer travel times were more likely to experience travel problems. Disease status was not associated with experiencing travel problems or the willingness to travel for oncological care. Instead, willingness to travel was associated with patients' level of education, physical functioning, and tumour type.</p><p><strong>Conclusion: </strong>Being diagnosed with self-reported curable or incurable cancer was not associated with experiencing travel problems or the willingness to travel for oncological care. Experiencing travel problems was associated with physical functioning and travel time, and the willingness to travel was associated with level of education, physical functioning, and tumour type. To ensure accessible and patient-centred care, physicians should be aware of these potential barriers and aim to provide well-coordinated, personalised care close to home.</p>","PeriodicalId":22046,"journal":{"name":"Supportive Care in Cancer","volume":"33 7","pages":"610"},"PeriodicalIF":2.8,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12183130/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144369217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations between area deprivation and mental health by household income among cancer caregivers.","authors":"Kyle Pitzer, Karla T Washington, Darrell L Hudson, Keisha White Makinde, Todd D Becker, Debra Parker Oliver, Jacquelyn J Benson, George Demiris","doi":"10.1007/s00520-025-09676-3","DOIUrl":"10.1007/s00520-025-09676-3","url":null,"abstract":"<p><strong>Purpose: </strong>Caregivers of patients diagnosed with cancer experience a variety of stressors related to their roles and responsibilities. Due to these stressors, mental health issues are much more prevalent among these caregivers than the general population. Individual and contextual factors may exacerbate these mental health issues, including where a caregiver lives. This study examined the association between area deprivation and mental health among caregivers of patients with cancer as well as differential associations based on household income.</p><p><strong>Methods: </strong>As part of a larger clinical trial for caregivers of patients with cancer receiving outpatient palliative care, caregivers completed demographic and baseline surveys from which the data were derived. To determine area deprivation, caregiver addresses were geocoded. Linear models were then estimated to assess the association between area deprivation and anxiety and depression and interactions between area deprivation and household income. Exploratory subgroup analyses based on hours of care provided per week were also performed.</p><p><strong>Results: </strong>While there was no significant association between area deprivation and depression regardless of household income, the models did indicate a cross-over association between area deprivation and anxiety by household income. Specifically, caregivers with annual household incomes less than $70,000 had greater anxiety as area deprivation increased while caregivers with household incomes greater than $70,000 had lesser anxiety as area deprivation increased, on average.</p><p><strong>Conclusion: </strong>The findings highlight the importance of considering both the financial situation and the living environment of caregivers when developing practices and clinical infrastructure to support those caring for cancer patients.</p>","PeriodicalId":22046,"journal":{"name":"Supportive Care in Cancer","volume":"33 7","pages":"614"},"PeriodicalIF":2.8,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144476718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Periodontal changes after haematopoietic cell transplantation and the role of conditioning regimen intensity.","authors":"Lucky L A van Gennip, Marjolein S Bulthuis, Gerjon Hannink, Ewald M Bronkhorst, Stephanie J M van Leeuwen, Nicole M A Blijlevens, Marie-Charlotte D N J M Huysmans, Renske Z Thomas","doi":"10.1007/s00520-025-09654-9","DOIUrl":"10.1007/s00520-025-09654-9","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate periodontal health after allogeneic haematopoietic cell transplantation (HCT), and its association with conditioning regimen intensity.</p><p><strong>Methods: </strong>This single-centre retrospective cohort study included 82 allogeneic HCT recipients between 01/08/2017 and 31/03/2022. Probing pocket depth (PPD), bleeding on probing (BOP), periodontal epithelial surface area (PESA) and periodontal inflamed surface area (PISA) were assessed pre- and post-HCT. Change scores were calculated, and regression models were applied to analyse associations with conditioning intensity. Conditioning regimens were categorised based on intensity as non-myeloablative (NMA), reduced intensity (RIC) or myeloablative (MA).</p><p><strong>Results: </strong>HCT recipients had a median age of 59 years (IQR 48-66); 63% were male. Median time to HCT was 53 days (IQR 29-89), median follow-up was 279 days (IQR 183-349). Severe periodontitis (≥ 1 site with PPD ≥ 6 mm) was observed in 37% of patients pre-HCT and 20% of patients post-HCT. PPD, BOP, PESA and PISA decreased from pre- to post-HCT, by 0.26 mm [95%CI 0.16;0.37], 8% [95%CI 5;12], 140 mm² [95%CI 89;190] and 123 mm² [95%CI 83;185], respectively. Prevalence of severe periodontitis decreased from pre- to post-HCT in all groups: NMA 50% to 27%, RIC 32% to 19%, MA 31% to 13%. Conditioning intensity was statistically significantly associated with post-HCT PPD and PESA; however, differences were small. No statistically significant differences were observed in post-HCT PISA between conditioning regimens.</p><p><strong>Conclusion: </strong>Periodontal health improved marginally in the short-term following HCT and supportive oral care. Differences in post-HCT periodontal health between patients conditioned with NMA, RIC, and MA were not clinically relevant.</p>","PeriodicalId":22046,"journal":{"name":"Supportive Care in Cancer","volume":"33 7","pages":"612"},"PeriodicalIF":2.8,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12185657/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144476723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk factors for chemotherapy-induced oral mucositis in cancer patients: a systematic review and meta-analysis.","authors":"Hui Zheng, Mingqi Zhang, Tingting Xiao, Yicen Zheng, Lianfang Cheng, Meiling Huang, Man Zhang, Lichun Xu","doi":"10.1007/s00520-025-09629-w","DOIUrl":"10.1007/s00520-025-09629-w","url":null,"abstract":"<p><strong>Purpose: </strong>This systematic review aims to identify the factors influencing chemotherapy-induced oral mucositis in cancer patients.</p><p><strong>Methods: </strong>A comprehensive literature search was conducted across PubMed, Web of Science, Embase, The Cochrane Library, VIP, Wanfang, CNKI, CBM, and CINAHL from the establishment of the databases to August 2024. Meta-analysis was performed using RevMan5.4 software, with odds ratios (OR) and 95% confidence intervals (CI) used to assess the risk factors. Methodological quality was assessed using the Newcastle-Ottawa Scale (NOS) and the evaluation criteria recommended by the Agency for Healthcare Research and Quality (AHRQ). The quality of evidence was graded using the GRADEpro GDT.</p><p><strong>Results: </strong>The analysis included 10 studies with a total of 2365 patients. Six studies were of high quality, and four studies were of moderate quality. The results indicated that the following factors were associated with an increased risk of chemotherapy-induced oral mucositis (CIOM) in cancer patients: a history of oral disease, combination chemotherapy, smoking history, oral hygiene, and chemotherapy regimens containing 5-FU/methotrexate.</p><p><strong>Conclusion: </strong>This meta-analysis identified several potential independent risk factors for CIOM in cancer patients. Early screening and timely intervention for patients with these risk factors are crucial for reducing the likelihood of CIOM and improving overall prognosis.</p>","PeriodicalId":22046,"journal":{"name":"Supportive Care in Cancer","volume":"33 7","pages":"613"},"PeriodicalIF":2.8,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144476763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}