Supportive Care in Cancer最新文献

{"title":"Perioperative symptom cluster characteristics and supportive care needs of sellar tumor patients: a cross-sectional study.","authors":"Nuerhuojia Yeernuer, Pengwei Lu, Liling Mao, Jiaxin Xu, Qiushi Wang, Rui Zhao","doi":"10.1007/s00520-025-09696-z","DOIUrl":"10.1007/s00520-025-09696-z","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the current situation of perioperative symptom clusters composition and supportive care needs of sellar tumor patients and to provide new insights into comprehensive nursing care for sellar tumor patients and other brain tumor patients.</p><p><strong>Methods: </strong>An observational study was conducted on patients diagnosed with sellar region tumors. A total of 122 sellar tumor patients admitted to CCMU Affiliated Beijing Tiantan Hospital from March to May 2024 were selected. The patients' symptoms and supporting care were evaluated using the M.D. Anderson Inventory Brain Tumor and 34 items of Supportive Care Need Scale. Assessments were conducted at baseline and within 3 days after the surgery. Exploratory factor analysis was used to extract symptom clusters, and Spearman was used to analyze the correlation between symptom severity and supportive care needs.</p><p><strong>Results: </strong>The most common and severe preoperative symptoms were visual change (68.0%) and dry mouth (55.7%), mainly manifesting as emotional distress, while the most common and severe postoperative symptoms were pain (94.3%) and dry mouth (94.3%), mainly manifesting as disturbances in general activities, work, and emotion. The cluster analysis of patients' symptoms showed that preoperative symptom clusters included psychological-related symptom cluster and neurological symptom cluster. Postoperative symptom clusters were slightly different, which included psychological-related symptom cluster, gastrointestinal symptom cluster, neurological system symptom cluster, sleep-related symptom cluster, and other symptom cluster. The score of preoperative supportive care needs was (74.8 ± 19.41), and the postoperative supportive care needs was (102.08 ± 14.95). The perioperative supportive care needs were positively correlated with symptom severity of the patients (P < 0.05).</p><p><strong>Conclusion: </strong>Sellar tumor patients have multiple symptom clusters and high supportive care needs during the perioperative period. When the patients have a high degree of symptoms, generally, they will have a higher level of supportive care needs. Medical staff should promptly assess patient's symptoms and implement targeted interventions to meet the needs of patients.</p>","PeriodicalId":22046,"journal":{"name":"Supportive Care in Cancer","volume":"33 8","pages":"676"},"PeriodicalIF":2.8,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144601621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"\"The disease and its treatment make you less of a woman\": self-reported experiences of women with breast cancer receiving care in Kumasi, Ghana.","authors":"Abigail Owusu Sekyere, Merri Iddrisu, Kennedy Dodam Konlan","doi":"10.1007/s00520-025-09744-8","DOIUrl":"https://doi.org/10.1007/s00520-025-09744-8","url":null,"abstract":"<p><strong>Introduction: </strong>Wo rldwide, breast cancer (BC) tops as the main cause of cancer deaths among females. Women who are diagnosed with breast cancer experience body changes, and these could lead to devastating social and economic consequences on the patients. However, there is minimal exploration on the physical and socioeconomic needs of women diagnosed with breast cancer in resource-constrained settings, hence this study.</p><p><strong>Aim: </strong>The study explored the self-reported experiences of women with breast cancer in a resource-constrained hospital in Ghana.</p><p><strong>Method: </strong>We adopted an exploratory qualitative design involving women diagnosed with BC at the Komfo Anokye Teaching Hospital in Kumasi, Ghana. We purposively selected fifteen (15) women diagnosed with BC receiving care at the study site. Using a pilot-tested semi-structured interview guide, the participants took part in in-depth interviews which were recorded. The audio files were then transcribed verbatim, and reflexive thematic analysis was done using Nvivo 10.0.</p><p><strong>Results: </strong>Two key sub-themes emerged regarding physical needs: keeping a positive outlook and physical comfort. On the socioeconomic needs, three sub-themes emerged: sexual, spiritual, and financial needs. The participants experienced sexual problems and difficulties in their sexual and social relationships because of their condition. It was noted that the participants are not supported by their husbands/partners. Likewise, the participants attributed spiritual reasons as the potential cause of their disease. In addition, treatment for BC was said to be expensive and unaffordable, and that apart from the direct cost of the treatment, patients are also required to travel from very far places for treatment.</p><p><strong>Conclusion: </strong>Breast cancer diagnosis among women comes with changes in physical outlook and self-esteem due to the loss of the breast, pain, breast ulcers, scars of treatment, alopecia, and breast ulcer discharge-associated body odor. Also, breast cancer treatment is expensive and inaccessible. In addition, spiritual connotations are associated with BC diagnosis. We recommend that nurses and other care professionals tackle the physical, social, and sexual problems associated with the diagnosis and treatment of BC using supportive care approaches such as intense counseling. Also, collaborative care with religious leaders of patients and sexual partners is encouraged to enhance acceptance of breast cancer diagnosis and treatment particularly in religiously charged settings.</p>","PeriodicalId":22046,"journal":{"name":"Supportive Care in Cancer","volume":"33 8","pages":"677"},"PeriodicalIF":2.8,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144601618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bridging cultural and digital gaps in oncology communication: commentary on Arraras et al.","authors":"Galip Can Uyar, Gökhan Şahin","doi":"10.1007/s00520-025-09730-0","DOIUrl":"https://doi.org/10.1007/s00520-025-09730-0","url":null,"abstract":"","PeriodicalId":22046,"journal":{"name":"Supportive Care in Cancer","volume":"33 8","pages":"673"},"PeriodicalIF":2.8,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144601619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early and late code status documentation in cancer patients managed by a dedicated supportive care team.","authors":"Lisa Choucroun, Yves Libert, Alexia Anastasoglou, Isabelle Libert, Emanuela Valentina Ligabo, Myriam Obiols Portis, Marie-Françoise Scharll, Isabelle Merckaert, Jean Klastersky","doi":"10.1007/s00520-025-09567-7","DOIUrl":"https://doi.org/10.1007/s00520-025-09567-7","url":null,"abstract":"<p><strong>Purpose: </strong>Given the end-of-life (EOL) focus of supportive care teams, clinicians in these settings may play a proactive role in facilitating early code status (CS) documentation (> 30 days before death) by fostering patients' and families' understanding, preparedness, and acceptance. This retrospective study was conducted to compare the incidence, types, and predictors of early and late CS documentation among patients managed by a dedicated supportive-care team.</p><p><strong>Methods: </strong>CS documentation data were extracted from the medical records of 134 deceased patients at a comprehensive cancer center. The incidence, types, and predictors (sociodemographic, medical, supportive care, and end-of-life-related characteristics) of early (> 30 days before death) and late (≤ 30 days before death) CS documentation were compared.</p><p><strong>Results: </strong>At the time of death, 85% of patients had documented CSs (early, 36%). The median (mean ± standard deviation) times of early and late CS documentation were 112 (174 ± 165) and 12 (12 ± 8) days before death, respectively. In early documentation, the do-not-resuscitate (DNR) CS was more common than the best-supportive-care (BSC) CS (54% vs. 46%); the reverse characterized late CS documentation (BSC 71% vs. DNR 29%). Predictors of early versus late CS documentation were being married/partnered [OR 3.05; 95% CI, 1.07-8.72; p = 0.038], gynecological/breast cancer diagnosis (OR 4.44; 95% CI, 1.22-16.12; p = 0.023), lung cancer diagnosis (OR 7.75; 95% CI, 1.99-30.15; p = 0.003), and performance status indicating minimal functional restriction at initiation of supportive care (OR 4.26; 95% CI, 1.13-16.14; p = 0.033).</p><p><strong>Conclusion: </strong>In the study context, CS documentation was frequent but often late. Although a dedicated supportive care team may allow a high overall frequency of CS documentation, additional clinical approaches are needed to promote earlier CS documentation.</p>","PeriodicalId":22046,"journal":{"name":"Supportive Care in Cancer","volume":"33 8","pages":"671"},"PeriodicalIF":2.8,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144592392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spinal analgesia in cancer pain management-MASCC general practice recommendations.","authors":"Sebastiano Mercadante, Kenneth Candido, Peter Staats, Mellar Davis","doi":"10.1007/s00520-025-09685-2","DOIUrl":"https://doi.org/10.1007/s00520-025-09685-2","url":null,"abstract":"<p><p>Patients with cancer pain refractory to conventional medical management may benefit from spinal analgesia, although there are some critical points regarding some aspects which cannot be examined by an evidence-based approach. A group of experts was selected by MASSC to provide clinical practice advice on the use of spinal drug delivery in patients with cancer-related pain. Refractory cancer pain should be considered a condition in which a patient has failed to receive adequate analgesia or has developed uncontrolled side effects after comprehensive pain management. The intrathecal route (IT) with an implantable drug delivery system allows the administration of minimal doses of analgesics with significant clinical effects while avoiding major adverse effects and lower risks with prolonged use. Morphine and hydromorphone are the opioids of choice for IT treatment. Local anesthetics are an added value because of their additive-synergic effect on segmental areas. The efficacy of adding small amounts of local anesthetics to an ITDD relies on the positioning of the tip of the catheter close to the dermatome where the origin of the pain comes from. Their use, however, depends on the delivery system, because larger volumes are necessary. Ziconotide requires a slow dose titration, but it can be used in small volumes. In addition, once doses are stabilized, no tolerance occurs. A conversion ratio of 100:1 between oral and IT morphine is suggested for patients who receive high doses of systemic opioids. A higher ratio (300:1) should be used in patients prevalently switched to the IT route for uncontrollable adverse effects, receiving lower doses of systemic opioids. The use of boluses of hydrophilic opioids, like morphine, for treating breakthrough pain may be inadequate, as intrathecal opioids alone may be unable to adequately treat an episode of rapid pain onset and duration. The decision-making process for employing interventional therapies, like spinal analgesia, should be shared, taking into account the actual indications and needs, previous treatments, prognosis, timing, advantages and disadvantages, and complications, in any individual situation, managing all the aspects of care.</p>","PeriodicalId":22046,"journal":{"name":"Supportive Care in Cancer","volume":"33 8","pages":"674"},"PeriodicalIF":2.8,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144601622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Virtual reality for cancer symptom management: a systematic review of randomized controlled trials.","authors":"Tuğçe Uçgun, Ebru Akgün Çitak","doi":"10.1007/s00520-025-09738-6","DOIUrl":"10.1007/s00520-025-09738-6","url":null,"abstract":"<p><strong>Purpose: </strong>This systematic review aimed to evaluate the effectiveness of VR interventions in managing symptoms and improving well-being among pediatric and adult cancer patients.</p><p><strong>Methods: </strong>In this study, between 2019 and 2024, randomized controlled studies were searched through PubMed (MEDLINE), EBSCO, and SCOPUS. MeSH (Medical Subjects Headings) were searched for keywords, and Boolean connectors were used to search for the keywords \"virtual reality\" AND (\"cancer\" OR \"cancer patients\"). Only randomized controlled trials focused specifically on symptom management and published in English were included in this systematic review. The quality of the studies was assessed using the Joanna Briggs Institute (JBI) critical appraisal tools, and The Cochrane Risk of Bias Tool 2.0 (RoB 2) was used to evaluate the risk of bias in randomized trials. The study is registered in PROSPERO with the registration number CRD42024582573.</p><p><strong>Results: </strong>A total of 637 articles were identified. After eliminating studies with repetitive and inappropriate subject titles, content, methods, or samples, 15 studies met the inclusion criteria. Among them, seven studies addressed pediatric populations and eight focused on adult patients. Quality appraisal indicated that four studies demonstrated strong methodological rigor, while the remaining eleven were rated as moderate. The included studies reported that VR interventions were effective in managing a wide range of physical symptoms (e.g., pain, nausea, fatigue, sleep quality, and vital signs) and psychological symptoms (e.g., anxiety, fear, depression, mood changes, and overall well-being) in both pediatric and adult cancer patients.</p><p><strong>Conclusion: </strong>Through a systematic review of 15 studies, our findings underscore VR's effectiveness in overall psychological well-being and comfort among pediatric and adult cancer patients. These results highlight VR as a valuable tool in comprehensive cancer care, emphasizing its potential to alleviate symptoms and enhance the quality of life in this population.</p>","PeriodicalId":22046,"journal":{"name":"Supportive Care in Cancer","volume":"33 8","pages":"672"},"PeriodicalIF":2.8,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144592394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An exploration of the relationship between perceived injustice and pain severity in breast cancer survivors: a structural equation model.","authors":"Eva Roose, Wouter Van Bogaert, Kenza Mostaqim, Eva Huysmans, Jo Nijs, C Paul van Wilgen, David Beckwée, Annick Timmermans, Christel Fontaine, Astrid Lahousse","doi":"10.1007/s00520-025-09655-8","DOIUrl":"https://doi.org/10.1007/s00520-025-09655-8","url":null,"abstract":"<p><strong>Purpose: </strong>The construct of perceived injustice is receiving increased attention in pain research due to its relationship with adverse pain outcomes. Even though cancer survivors face a 30% risk of developing pain, there is a notable lack of research exploring this relationship within this population. Therefore, this study aims to explore the relationship of perceived injustice with pain severity in breast cancer survivors (BCS).</p><p><strong>Methods: </strong>A directed acyclic graph (DAG) (i.e., path model) was multidisciplinary created a priori, positioning perceived injustice -measured with the Injustice Experienced Questionnaire (IEQ)- as the main exposure variable and pain severity -measured with the Brief Pain Inventory (BPI)- as the main outcome variable, with the addition of explanatory variables within the relationship of IEQ and BPI. Data from 156 female BCS with pain and perceived injustice were analysed using structural equation modelling, with confidence intervals estimated through Montecarlo simulation.</p><p><strong>Results: </strong>Perceived injustice did not have a significant univariate direct relationship with pain severity (β = 0.186, p = 0.102). However, in the complete path model including explanatory outcomes, a significant relationship was observed (β = 0.304, 95% CI [0.136; 0.477]), explaining 22,5% of the variance in pain severity. In the complete model, the greatest proportion of the effect was mediated through pain catastrophizing (β = 0.226, 95% CI [0.101; 0.376]).</p><p><strong>Conclusion: </strong>The findings indicate that perceived injustice has an important relationship with pain severity levels of BCS experiencing pain and perceived injustice. Multimodal intervention studies are suggested for future investigation as a treatment for pain in BCS.</p><p><strong>Registration prior to recruitment at: </strong>ClinicalTrials.gov NCT04730154.</p>","PeriodicalId":22046,"journal":{"name":"Supportive Care in Cancer","volume":"33 8","pages":"670"},"PeriodicalIF":2.8,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144592391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"End-of-life healthcare use and associated costs for First Nations Australians diagnosed with cancer in Queensland, Australia.","authors":"Shafkat Jahan, Daniel Lindsay, Abbey Diaz, Ming Li, Kalinda Griffiths, Ian Olver, Gail Garvey","doi":"10.1007/s00520-025-09725-x","DOIUrl":"10.1007/s00520-025-09725-x","url":null,"abstract":"<p><strong>Purpose: </strong>Cancer significantly impacts First Nations Australians, with higher incidence and lower survival rates. However, understanding of end-of-life (EOL) service use and costs in this population is limited. We aimed to assess EOL healthcare utilisation and costs for First Nations cancer patients in Queensland, Australia.</p><p><strong>Methods: </strong>Retrospective data from CancerCostMod, a linked administrative dataset of all cancer diagnoses in Queensland, were used. This dataset includes records from the Queensland Cancer Registry (QCR) from July 1, 2011, to June 30, 2015, linked to Queensland Health Admitted Patient Data Collection (QHAPDC), Emergency Department (ED) Information Systems, Medicare Benefits Schedule (MBS), and Pharmaceutical Benefits Scheme (PBS) data from July 2011 to June 30, 2018. All diagnosed cancer patients who had died during the study period (N = 467) were included. Health service usage and costs during the last 6 months of life were described and compared across care type, comorbidity status, age group, and residential remoteness using Mann-Whitney and Kruskal-Wallis tests.</p><p><strong>Results: </strong>Individuals had at least one hospital episode (100%), ED visit (83%), MBS claim (96%), and PBS claim (96%). The median overall cost per person for hospital episodes was AUD$40,996, with higher costs for those receiving palliative care (AUD$43,521) and chemotherapy (AUD$50,437) compared to those who did not receive these services (palliative: AUD$34,208, chemotherapy: AUD$38,557). Having comorbidities and living in regional and remote areas were associated with higher hospital costs.</p><p><strong>Conclusion: </strong>The study findings may guide the re-design and delivery of optimal and culturally appropriate EOL care for First Nations Australians diagnosed with cancer.</p>","PeriodicalId":22046,"journal":{"name":"Supportive Care in Cancer","volume":"33 8","pages":"669"},"PeriodicalIF":2.8,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12238182/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144592393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patterns of medication use following breast cancer diagnosis: an Australian population-based study.","authors":"Huah Shin Ng, Christoffer Johansen, Ming Li, David Roder, Kerri Beckmann, Bogda Koczwara","doi":"10.1007/s00520-025-09732-y","DOIUrl":"10.1007/s00520-025-09732-y","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to examine patterns of medication use and polypharmacy following breast cancer diagnosis.</p><p><strong>Methods: </strong>This retrospective cohort study used breast cancer data from the South Australian Cancer Registry linked with medication dispensing records, death registry, and inpatient hospital records. Women diagnosed with invasive breast cancer between July 2012 and March 2014 were followed for 5 years from diagnosis. All medications were defined using the Anatomical Therapeutic Chemical classification, and patterns of use were analysed in one-yearly intervals. The changes in the use of medications and polypharmacy (≥ 5 concomitant medications versus not) from Year-2 to Year-5 of breast cancer diagnosis were examined using generalised estimating equations models with binary logistic distribution.</p><p><strong>Results: </strong>The study included 2005 women (mean age = 61.1 years). The use of endocrine therapy for breast cancer decreased over time (odds ratio (OR) 0.88; 95%CI = 0.86-0.90). In contrast, the likelihood of being dispensed specific cardiovascular medicines increased with each successive time period including agents acting on renin-angiotensin system (OR 1.03; 95%CI = 1.01-1.05), lipid-modifying agents (OR 1.06; 95%CI = 1.03-1.08), beta-blockers (OR 1.08; 95%CI = 1.04-1.11), and cardiac therapy (OR 1.12; 95%CI = 1.06-1.18). There was an increased likelihood of polypharmacy over time (OR 1.08; 95%CI = 1.04-1.11) with the prevalence ranging from 25% (Year 2) to 29% (Year 5). Several characteristics were associated with polypharmacy including older age, a lower socioeconomic status, and a higher burden of comorbidities.</p><p><strong>Conclusion: </strong>The use of several medication classes increased over time suggesting development of new comorbidities and higher likelihood of polypharmacy. Medication management in breast cancer survivors offers potential to identify those with complex needs of polypharmacy and comorbidity.</p>","PeriodicalId":22046,"journal":{"name":"Supportive Care in Cancer","volume":"33 8","pages":"668"},"PeriodicalIF":2.8,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12238185/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144584886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pain and lymphedema characteristics of women with breast cancer-related lymphedema with and without type 2 diabetes mellitus.","authors":"Esra Uzelpasaci, Aysel Ozge Kemer, Ozgu Inal Ozün, Aysegül Yaman","doi":"10.1007/s00520-025-09728-8","DOIUrl":"https://doi.org/10.1007/s00520-025-09728-8","url":null,"abstract":"<p><strong>Aim: </strong>This study aimed to compare the pain and lymphedema characteristics of women with breast cancer-related lymphedema (BCRL) with and without type 2 diabetes mellitus (T2DM).</p><p><strong>Methods: </strong>A case-control study was conducted with 105 breast cancer survivors diagnosed with unilateral BCRL, divided into T2DM (n = 51) and non-T2DM (n = 54) groups. For pain characteristics, Visual Analog Scale (VAS) and Self-administered Leeds Assessment of Neuropathic Symptoms and Signs (S-LANSS) were used. In addition, circumference measurement, the Lymphedema Life Impact Scale (LLIS), and Lymphedema Quality of Life Questionnaire (LYMQOL) were applied to determine the severity of lymphedema and its impact on quality of life. Statistical analysis was performed using t-tests, Mann-Whitney U tests, and Chi-square tests.</p><p><strong>Results: </strong>T2DM patients exhibited significantly higher pain intensity (VAS) (p <math><mo><</mo></math> 0.001, t =   ‒ 4.148), neuropathic symptoms (S-LANSS ≥ 12 in 72.5% vs. 18.5%) (p <math><mo><</mo></math> 0.001, t = ‒ 6.435), and poorer quality of life metrics (LLIS-physical concerns, LLIS-psychococial concerns, LYMQOL-function, LYMQOL-appearance, LYMQOL-symptoms, LYMQOL-mood, LYMQOL-total) compared to the non-T2DM group (p₁ <math><mo><</mo></math> 0.001, t₁ = ‒ 3.661; p₂ = 0.016, t₂ = ‒ 2.461; p₃ = 0.004, t₃ = ‒ 2.963; p₄ <math><mo><</mo></math> 0.001, z = ‒ 3.483; p₅ <math><mo><</mo></math> 0.001, t₅ = ‒ 3.891; p₆ = 0.018, t₆ = ‒ 2.396; p₇ = 0.001, t₇ = ‒ 3.544). Lymphedema severity (p <math><mo><</mo></math> 0.001), volume (p <math><mo><</mo></math> 0.001, z = ‒ 3.716) and duration (p <math><mo><</mo></math> 0.001, z = ‒ 3.716) were also significantly higher in the T2DM group. Despite these differences, the place of onset of lymphedema, LLIS functional concerns and LYMQOL 21st question (How much lymphedema affects overall quality of life on a scale from 0: not at all to 10: a great deal) were similar in both groups (p > 0.05).</p><p><strong>Conclusion: </strong>T2DM significantly amplifies pain and worsens lymphedema-related outcomes in BCRL patients, underscoring the need for targeted, multidisciplinary interventions that address metabolic, physical, and psychosocial factors. Although lymphedema severity, duration, and volume were significantly higher in the T2DM group, these factors may have also contributed to the reduced functional status and quality of life outcomes independently of T2DM. Future research should explore the long-term relationship between T2DM, pain, and lymphedema to develop comprehensive care strategies for this population.</p>","PeriodicalId":22046,"journal":{"name":"Supportive Care in Cancer","volume":"33 8","pages":"666"},"PeriodicalIF":2.8,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144584885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}