Supportive Care in Cancer最新文献

{"title":"The association of oxaliplatin-induced peripheral neuropathy and falls with intercycle delays and early discontinuation of chemotherapy in older colorectal cancer patients.","authors":"Robert B Hines, Xiang Zhu, Christopher Schoborg, Stephanie Sutton, Eunkyung Lee, Shunpu Zhang","doi":"10.1007/s00520-025-09924-6","DOIUrl":"10.1007/s00520-025-09924-6","url":null,"abstract":"<p><strong>Purpose: </strong>Oxaliplatin chemotherapy improves survival in patients with colorectal cancer, but a common dose-limiting toxicity is oxaliplatin-induced peripheral neuropathy (OIPN). The purpose of this study was to assess the association between OIPN and falls with intercycle delays and early discontinuation of oxaliplatin chemotherapy.</p><p><strong>Methods: </strong>Colorectal cancer patients in this study were obtained from the Surveillance, Epidemiology, and End Results database combined with Medicare claims data (SEER-Medicare). All patients were ≥ 66 years of age at diagnosis. OIPN and falls were considered time-dependent exposures and were identified by diagnosis codes. Intercycle chemotherapy delay was defined as receipt of chemotherapy ≥ 7 days after the planned chemotherapy date. Early discontinuation was determined according to the chemotherapeutic regimen (infusional 5-FU < 6 cycles, oral capecitabine < 4 cycles). Poisson regression with generalized estimating equations and 95% confidence intervals was used to obtain adjusted incidence rate ratios (IrR) and rate differences (IrD) for intercycle delays and risk ratios (RR) and risk differences (RD) for early discontinuation.</p><p><strong>Results: </strong>A total of 3802 patients were available for analysis. Intercycle oxaliplatin delay occurred in 57.7% of subjects (n = 2194). OIPN (IrR = 1.87: 95% CI, 1.67-2.10; IrD = 2.09 delays/81 person-days: 95% CI, 1.48-2.69) and falls (IrR = 2.62: 95% CI, 2.06-3.34; IrD = 3.30 delays/81 person-days: 95% CI, 1.96-4.64) were associated with increased rates of delay. Early discontinuation of chemotherapy occurred in 22.1% of patients (n = 841). OIPN (RR = 2.51: 95% CI, 1.78-3.55; RD = 7.2%; 95% CI, 3.0-11.4%) and falls (RR = 2.19; 95% CI, 1.24-3.85) were also associated with increased risks of early discontinuation.</p><p><strong>Conclusion: </strong>Patients who experience intercycle delays and early discontinuation of scheduled chemotherapy treatment may experience poorer cancer-related outcomes. Therapeutics to prevent and treat OIPN and fall prevention strategies are needed to decrease the likelihood of chemotherapy treatment disruptions in older colorectal cancer patients.</p>","PeriodicalId":22046,"journal":{"name":"Supportive Care in Cancer","volume":"33 10","pages":"880"},"PeriodicalIF":3.0,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145150905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"\"We're the silent people in the situation\": a qualitative examination of the lived experiences of young partners of men diagnosed with testicular cancer.","authors":"Fiona S M Schulte, Perri Tutelman, Emily Memedovich, Caitlin Forbes, Brian Kelly, Zeev Rosberger, Cindy Railton, Igor Stukalin, Barry D Bultz","doi":"10.1007/s00520-025-09959-9","DOIUrl":"10.1007/s00520-025-09959-9","url":null,"abstract":"<p><strong>Background/purpose: </strong>Testicular cancer (TC) is one of the most prevalent cancers among young adult (YA) males. TC can have significant physical and psychosocial impacts on patients, however limited research has focused on the experiences of their young partners. Thus, the aim of this study was to explore the lived experiences of partners of individuals diagnosed with TC as YAs.</p><p><strong>Methods: </strong>This study used an interpretive phenomenological research design. Three focus groups with 4-5 participants per group were conducted with partners of individuals diagnosed with TC as YAs (n = 13; 100% female; mean age = 30.77 years [SD = 6.10]). The majority of partners were married (n = 8) and met prior to the TC diagnosis (n = 11). Data were analyzed using reflexive thematic analysis.</p><p><strong>Results: </strong>Three overarching themes were generated that describe the partners' experiences: (1) as caregivers, partners must balance various new roles and responsibilities which becomes a large part of their identity; (2) caregivers suffer silently with their partner's diagnosis, minimizing their own experiences and emotions due to guilt and fear of being a burden; and (3) partners must confront a future that is different than expected as a result of the cancer experience.</p><p><strong>Conclusions: </strong>Partners experienced unique emotional and practical challenges when supporting their partner throughout their TC experience. The results of this study highlight the need for improved support and resources tailored to partners of YAs diagnosed with TC.</p>","PeriodicalId":22046,"journal":{"name":"Supportive Care in Cancer","volume":"33 10","pages":"883"},"PeriodicalIF":3.0,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145178613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dependence and clinical fragility in hematopoietic stem cell transplant and CAR-T therapy: a retrospective study.","authors":"Marco Cioce, Matteo Raponi, Chiara Visintini, Domenico Pascucci, Stefano Botti, Patrizia Laurenti, Carmen Nuzzo, Giuseppe Vetrugno, Nicola Nicolotti, Angela Iula, Simona Sica, Patrizia Cornacchione, Simona Calza, Sarah Jayne Liptrott","doi":"10.1007/s00520-025-09925-5","DOIUrl":"10.1007/s00520-025-09925-5","url":null,"abstract":"<p><strong>Purpose: </strong>Autologous and allogeneic hematopoietic stem cell transplantation and CAR-T cell therapy are standard treatments for patients affected by hematologic malignancies at different stages of their clinical pathway. Several adverse events accompany these therapies during patients' hospital stay, including psycho-emotional distress and various functional and social impairments.</p><p><strong>Methods: </strong>In this monocentric study on 498 patients, various clinical and social fragility indices, registered within clinical documentation during the hospital stay, specifically at admission (within 24 h of entry) and discharge (less than 24 h prior to leaving), were retrospectively assessed with the aim of describing their trends and evaluating for differences between type of cell therapy and underlying disease.</p><p><strong>Results: </strong>Functional independence mean score was lower in allogeneic patients at admission (p = 0.001) and at discharge (p = 0.001), while a higher risk of falling at discharge (p = 0.001), an increased risk of clinical deterioration at admission (p = 0.001) and at discharge (p = 0.011), and increased complexity of care at both time points (p = 0.001) were observed in patients undergoing CAR-T compared to patients undergoing allogeneic or autologous HSCT procedures. Acute lymphoid leukemia patients had significantly worse mean scores at both time points for functional independence, risk of falling, clinical deterioration, care complexity, level of pain (p =  < 0.001); while acute myeloid leukemia patients had higher risk of skin pressure injuries at discharge (p = 0.036).</p><p><strong>Conclusion: </strong>Our findings may contribute to improving personalized assessment strategies in the field of cell therapy, including both CAR-T therapy and stem cell transplantation. They highlight the increased risk and complexity of care, particularly in patients receiving CAR-T therapy, while emphasizing the need for tailored management approaches across different cell therapy modalities.</p>","PeriodicalId":22046,"journal":{"name":"Supportive Care in Cancer","volume":"33 10","pages":"881"},"PeriodicalIF":3.0,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12464104/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145150908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treatment-related adverse events as a source of financial hardship in young adults with breast cancer: a qualitative study.","authors":"Sara P Myers, Ramona G Olvera, Sandy Lee, Karen Shiu, Tessa Blevins, Willi L Tarver, William E Carson, Electra D Paskett, Samilia Obeng-Gyasi, Ann Scheck McAlearney","doi":"10.1007/s00520-025-09887-8","DOIUrl":"10.1007/s00520-025-09887-8","url":null,"abstract":"<p><strong>Purpose: </strong>Rates of breast cancer are increasing among young adult (YA) women aged ≤ 40 years. YAs face unique challenges, including being at high risk for financial hardship. Treatment-related adverse events may represent a modifiable and often overlooked source of financial hardship. In this interview-based study, the narratives of YAs with breast cancer were analyzed to understand how treatment-related adverse events contributed to medical and non-medical costs and long-term economic burden.</p><p><strong>Methods: </strong>In this secondary analysis of semi-structured interviews characterizing financial toxicity among adult women with stage I-IV breast cancer treated at The Ohio State University Comprehensive Cancer Center (OSUCCC) between 1/1/2015 and 12/31/2019, previously transcribed and coded data from women ≤ 40 years old was analyzed using inductive and deductive approaches.</p><p><strong>Results: </strong>Twenty breast cancer survivors aged ≤ 40 years participated. Treatment-related adverse events emerged as an important factor contributing to financial toxicity. Participants described complications in nearly every organ system, many of which were disabling and required intervention. While indirect (e.g., job loss, reduced work hours) and direct sources (e.g., compression garments for lymphedema) of costs were noted to cause psychological distress and impact treatment adherence, participants did articulate possible solutions for reducing financial hardship (e.g., direct cash transfer, financial navigation).</p><p><strong>Conclusion: </strong>Treatment-related adverse events can contribute to financial toxicity after breast cancer through direct and indirect costs. Among young adults, indirect costs can include those that result from vocational disruption. Strategies to reduce the risk of financial toxicity should be included in care pathways to address complications of treatment itself.</p>","PeriodicalId":22046,"journal":{"name":"Supportive Care in Cancer","volume":"33 10","pages":"884"},"PeriodicalIF":3.0,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12474583/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145178626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Construction of a predictive model for the risk of moderate-to-severe cancer-related fatigue in colorectal cancer chemotherapy patients: an interpretable machine learning approach.","authors":"Tian Xiao, Fangyi Li, Linyu Zhou, Ruihan Xiao, Ting Chen, Xiaoli Huang, Qing Li, Ya Zhang, Ling Yang, Xueqin Qiu, Xiaoju Chen","doi":"10.1007/s00520-025-09950-4","DOIUrl":"10.1007/s00520-025-09950-4","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to analyze the influencing factors of moderate-to-severe cancer-related fatigue (CRF) in colorectal cancer (CRC) chemotherapy patients and to develop a predictive risk stratification model.</p><p><strong>Methods: </strong>A total of 630 CRC chemotherapy patients were selected from five hospitals in China. Data were collected using a general information forms, the Piper Fatigue Scale-Revised (PFS-R), the Hospital Anxiety and Depression Scale (HADS), and the Pittsburgh Sleep Quality Index (PSQI). The data was randomly divided into a training set and a test set in a 7:3 ratio, and feature selection was performed using univariate analysis and LASSO regression. Five machine learning algorithms were used to construct moderate-to-severe CRF models. The Shapley additive explanation (SHAP) method is used to increase the interpretability of the optimal performance model.</p><p><strong>Results: </strong>The overall incidence of moderate-to-severe CRF was 70.5%. The random forest (RF) model performed the best, with an AUC of 0.906, sensitivity of 0.943, accuracy of 0.931, precision of 0.977, specificity of 0.848, and F1 score of 0.960. Based on the analysis of the absolute mean SHAP values, the feature importance of the RF model, from highest to lowest, was sleep quality score, anxiety score, anorexia, magnesium ion concentration, smoking history, place of residence, and cancer stage.</p><p><strong>Conclusions: </strong>The RF model demonstrated superior predictive performance, positioning it as a viable screening tool for assessing the risk of moderate-to-severe CRF in CRC patients receiving chemotherapy. This approach may facilitate early intervention and improve clinical management of CRF symptoms.</p>","PeriodicalId":22046,"journal":{"name":"Supportive Care in Cancer","volume":"33 10","pages":"882"},"PeriodicalIF":3.0,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145150897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on \"The effect of exercise on cognitive function in breast cancer survivors: systematic review and meta-analysis of randomized controlled trials\".","authors":"Bhaskar Kambhampati, Rachana Mehta, Ranjana Sah","doi":"10.1007/s00520-025-09957-x","DOIUrl":"10.1007/s00520-025-09957-x","url":null,"abstract":"","PeriodicalId":22046,"journal":{"name":"Supportive Care in Cancer","volume":"33 10","pages":"877"},"PeriodicalIF":3.0,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145138861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of exercise-based prehabilitation on cardiometabolic health in surgical patients with cancer: a systematic review and meta-analysis.","authors":"Manuel Fernandez-Escabias, Javier Jurado, Sofia Carrilho-Candeias, Andrea Orellana-Jaen, Pablo Corres, Andres Marmol-Perez, Carl J Lavie, Almudena Carneiro-Barrera, Teresa Nestares, Francisco J Amaro-Gahete","doi":"10.1007/s00520-025-09940-6","DOIUrl":"10.1007/s00520-025-09940-6","url":null,"abstract":"<p><strong>Objective: </strong>This systematic review and meta-analysis aimed to establish the effects of exercise-based prehabilitation programs on cardiometabolic health in patients with cancer undergoing surgery.</p><p><strong>Data source: </strong>A systematic search was conducted in MEDLINE (via PubMed) and Web of Science from inception to June 2023.</p><p><strong>Study selection: </strong>The original systematic search retrieved 16,752 studies. After removal of duplicates and screening by title and abstract, 200 articles were eligible for full-text revision. Finally, a total of nine randomized controlled trials (RCTs), four controlled studies, and six uncontrolled before-and-after studies were included.</p><p><strong>Outcome measures: </strong>Changes in blood pressure (systolic and diastolic), lipid metabolism (total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, and triglycerides levels), glycemic metabolism (fasting glucose, insulin, homeostatic model assessment for insulin resistance, and insulin-growth factor-1), and inflammatory biomarkers (i.e., interleukin-6, tumor necrosis factor-alpha, c-reactive protein, and vascular endothelial growth factor) were assessed.</p><p><strong>Results: </strong>The total sample was composed of 651 participants (n = 311 intervention and n = 239 control from RCTs and controlled studies; n = 101 intervention from before-and-after studies), aged 64.90 ± 8.87 years (33.76% women). The meta-analyses of uncontrolled before-and-after studies revealed significant prehabilitation-induced reductions in systolic and diastolic blood pressure (d =  - 0.47 and - 0.57, respectively). However, no changes were noted in lipid and glycemic metabolism or inflammatory biomarkers in either controlled or uncontrolled before-and-after studies.</p><p><strong>Limitations: </strong>These findings should be interpreted with caution. The small evidence base, inclusion of uncontrolled designs, substantial between-study heterogeneity, and the possibility of publication bias limit the robustness and generalizability of the conclusions.</p><p><strong>Conclusions: </strong>Exercise-based prehabilitation programs seems to be effective at reducing blood pressure in patients with cancer undergoing surgery. No effects were noted in other cardiometabolic health outcomes included.</p>","PeriodicalId":22046,"journal":{"name":"Supportive Care in Cancer","volume":"33 10","pages":"879"},"PeriodicalIF":3.0,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145150884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of a digital home self-care rehabilitation program for breast cancer patients post-surgery based on traditional Chinese medicine nursing diagnostics: a Delphi study.","authors":"Yan He, Zhi Ouyang, Qun Li, Ping Liu, Junru Yi, Luxi Yi, Yun Deng, Jing Yang, Ping Guo, Yaoyue Luo","doi":"10.1007/s00520-025-09913-9","DOIUrl":"10.1007/s00520-025-09913-9","url":null,"abstract":"<p><strong>Purpose: </strong>To develop a rigorous and standardized digital home self-care rehabilitation program for breast cancer patients' post-surgery, based on traditional Chinese medicine (TCM) nursing diagnostics.</p><p><strong>Methods: </strong>The initial draft of a digital rehabilitation module based on the WeChat mini-program was prepared through Literature research, patient surveys, expert interviews, And group discussions. A two-round Delphi method was used to consult 16 experts, revising, adding, and removing elements to finalize the rehabilitation plan.</p><p><strong>Results: </strong>The response rate for both rounds of the Delphi expert consultation was 100%, with authority coefficients of 0.813 And 0.841, respectively, and Kendall's coefficient of concordance values of 0.789 And 0.513 (both P < 0.001). The final plan includes 3 primary entries, 8 secondary entries, And 10 tertiary entries. Analytical hierarchy process results showed that the consistency ratio (CR) values for all matrices of the tertiary entries were < 0.1, meeting the requirements for consistency tests.</p><p><strong>Conclusion: </strong>The constructed digital home self-care rehabilitation program for postoperative breast cancer patients, developed through evidence synthesis and expert consensus using Delphi consultation and AHP, is methodologically rigorous, reliable, and clinically applicable.</p><p><strong>Trial registration: </strong>ClinicalTrials.gov Identifier: ITMCTR2024000368.</p>","PeriodicalId":22046,"journal":{"name":"Supportive Care in Cancer","volume":"33 10","pages":"878"},"PeriodicalIF":3.0,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12464138/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145138889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical and discharge outcomes in an acute palliative care unit located in a comprehensive cancer center.","authors":"Sebastiano Mercadante, Yasmine Grassi, Claudio Adile, Giorgio Sapienza, Alessio Lo Cascio, Alesssandra Casuccio","doi":"10.1007/s00520-025-09938-0","DOIUrl":"10.1007/s00520-025-09938-0","url":null,"abstract":"<p><strong>Purpose: </strong>The aim of this study was, other than assessing clinical outcomes after a comprehensive palliative care treatment in APCU, to report the activity and functioning of APCU in influencing subsequent care trajectory and settings of patients with advanced cancer.</p><p><strong>Patients and methods: </strong>A consecutive sample of patients with cancer who were admitted to an acute palliative care unit (APCU) was prospectively assessed. All patients underwent comprehensive palliative care treatment. At admission (T0), patients' demographics, reasons for admission, referral, and recent anticancer treatments were recorded, along with whether they were on/off treatment or uncertain. Subsequent referrals to next care settings and the pathway of oncologic treatment were reconsidered. Symptom intensity was measured by Edmonton Symptom Assessment Scale (ESAS).</p><p><strong>Results: </strong>Five-hundred and twenty patients were surveyed. Clinical deterioration was the most frequent indication for APCU admission. Most admissions were planned (60.8%). At discharge, a significant decrease in the number of \"on therapy\" patients was reported, and concomitantly, the number of \"off-therapy\" patients increased (p < 0.0005) in comparison with data recorded at admission. A significant number of patients was assigned to a palliative care setting, including home palliative care or hospice at the time of discharge (p < 0.0005). All ESAS items that significantly improved during admission were significant. Being \"off therapy\" was independently associated with a lower Karnofsky (p = 0.002), higher global ESAS at discharge (p = 0.032), and discharge to a palliative setting (hospice or home palliative care) (p < 0.0005).</p><p><strong>Conclusion: </strong>Data from the present study has shown that APCU results in a crossroad for patients with advanced cancer, allowing selection for transition of care.</p>","PeriodicalId":22046,"journal":{"name":"Supportive Care in Cancer","volume":"33 10","pages":"876"},"PeriodicalIF":3.0,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145131667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The potential and limitations of pain as a prognostic indicator in older adults with cancer.","authors":"Fan Wu, Jiaqi Cheng, Rui Wu","doi":"10.1007/s00520-025-09943-3","DOIUrl":"10.1007/s00520-025-09943-3","url":null,"abstract":"","PeriodicalId":22046,"journal":{"name":"Supportive Care in Cancer","volume":"33 10","pages":"874"},"PeriodicalIF":3.0,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145131710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}