Supportive Care in Cancer最新文献

{"title":"Effect of travel distance on utilization of ancillary services among patients with pancreatic ductal adenocarcinoma: A single institution study.","authors":"Revathi Myneni, Priya Pathak, Amy Hacker-Prietz, Jin He, Rachit Kumar, Amol K Narang","doi":"10.1007/s00520-025-09339-3","DOIUrl":"https://doi.org/10.1007/s00520-025-09339-3","url":null,"abstract":"<p><strong>Background: </strong>Fragmentation of care among patients with pancreatic cancer between specialized tertiary centers and community centers may be associated with increased patient burden and poorer outcomes. However, the impact of distance from a tertiary center on utilization of key ancillary services such as dietician consultation, and palliative or pain medicine consultation is unclear. We sought to examine how this travel distance influences the utilization of key ancillary services.</p><p><strong>Methods: </strong>This retrospective cohort study included 200 consecutive patients who were seen for a diagnosis of pancreatic ductal adenocarcinoma (PDAC) in 2021. Patients were grouped by travel distance: < 12.5, 12.5-49, and > 50 miles. Demographics, disease staging, and use of key ancillary services such as, dietician consultation, palliative, and pain medicine consultation were compared. Multiple logistic regression assessed associations between travel distance and ancillary service utilization.</p><p><strong>Results: </strong>Of the 200 patients, 14.5% traveled < 12.5 miles, 39.5% traveled 12.5-49 miles, and 46% traveled over 50 miles to our institution. Patients living over 50 miles away were significantly more likely to receive chemotherapy and radiation locally (81.8% vs 44.4%, p < 0.001). Importantly, they were less likely to utilize key ancillary services, including registered dietician consultation (Odds Ratio (OR) 0.34, p = 0.03), pancreatic enzyme prescriptions (OR 0.35, p = 0.03), pain medicine consultation (OR 0.20, p < 0.01), and palliative care consultation (OR 0.24, p < 0.01) compared to those living closer.</p><p><strong>Conclusions: </strong>Patients living over 50 miles from our institution were significantly less likely to receive key supportive services. Despite similar clinical characteristics, these disparities show how initiatives are necessary to guarantee equitable access to comprehensive cancer care, regardless of geographic location.</p>","PeriodicalId":22046,"journal":{"name":"Supportive Care in Cancer","volume":"33 4","pages":"282"},"PeriodicalIF":2.8,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143634295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cancer-related alopecia and wig acquisition: how age, sex, and treatment affect patient choices.","authors":"Hideki Katayama, Eiki Ichihara, Ayako Morita, Go Makimoto, Shunsuke Kagawa, Ayano Ishii, Masahiro Tabata, Yoshinobu Maeda","doi":"10.1007/s00520-025-09318-8","DOIUrl":"10.1007/s00520-025-09318-8","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to explore the prevalence and cost of wig purchases among patients with cancer in Okayama Prefecture, Japan, and examine the relationship between wig purchases and various demographic, social, and clinical factors. The findings aim to provide insights into appearance care and support systems for patients with cancer, particularly wig subsidies.</p><p><strong>Methods: </strong>A survey was conducted between July and August 2023 among 3000 patients with cancer at 13 designated cancer care hospitals in Okayama Prefecture. Data on demographics, cancer treatment status, and wig purchase details were collected. Statistical analyses, including the Mann-Whitney U test, chi-square test, and logistic regression, were performed to identify factors significantly associated with wig purchases.</p><p><strong>Results: </strong>Among the 863 respondents, 31.4% (271 patients) reported purchasing wigs. Factors significantly associated with wig purchase included young age (odds ratio [OR] = 1.04), female sex (OR = 1.61), and current cancer treatment (OR = 1.16). No significant correlation was found between wig purchase and household income, although higher-income patients tended to purchase more expensive wigs.</p><p><strong>Conclusion: </strong>The findings suggest that younger female patients with cancer and those undergoing treatment were more likely to purchase wigs, highlighting the importance of appearance care and the need for enhanced financial support for low-income patients.</p>","PeriodicalId":22046,"journal":{"name":"Supportive Care in Cancer","volume":"33 4","pages":"283"},"PeriodicalIF":2.8,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11910427/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143634279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global prevalence and risk factors of suicidality among head and neck cancer patients-systematic review and meta-analysis.","authors":"Shivani Sharma, Srivatsa Surya Vasudevan, Nakoma Walker, Gaelen Shimkus, Shriya Goyal, John Pang, Kavitha Beedupalli, Cherie-Ann O Nathan","doi":"10.1007/s00520-025-09244-9","DOIUrl":"https://doi.org/10.1007/s00520-025-09244-9","url":null,"abstract":"<p><strong>Purpose: </strong>Suicidality is a pertinent issue among head and neck cancer patients. Our primary aim is to investigate the current suicidality rate among head and neck cancer (HNC) patients and evaluate risk factors associated with suicidality.</p><p><strong>Methods: </strong>We thoroughly searched primary original research from January 2024 onwards across several databases, including PubMed, Embase, ScienceDirect, Web of Science, Scopus, and PsycINFO. Using a random-effects model, we calculated the odds ratio (OR) for risk factors and conducted a proportional meta-analysis to estimate prevalence and 95% confidence intervals (CI).</p><p><strong>Results: </strong>Out of 15 included studies, 305,146 head and neck cancer patients were included. The global prevalence of suicidality among head and neck cancer patients was estimated at 6.8% (95% CI 2.0-20.6%). Major depressive disorder (RR = 5.13, 95% CI 3.60-7.30), psychiatric disorders (RR = 3.73, 95% CI 2.65-5.25), alcohol abuse (RR = 2.67, 95% CI 1.71-4.16), substance abuse (RR = 2.47, 95% CI 1.58-3.85), smoking/nicotine dependence (RR = 2.03, 95% CI 1.60-2.58), and functional compromise (RR = 1.74, 95% CI 1.29-2.36) were identified as significant risk factors. Subgroup analysis by geographical location revealed variations in prevalence, with Asia reporting lower rates than Europe and North America.</p><p><strong>Conclusion: </strong>This systematic review reports the current suicidality rate associated with head and neck cancer patients. Major depressive disorder and other psychiatric comorbidities pose substantial risks requiring early intervention in mitigating the burden of suicidality.</p>","PeriodicalId":22046,"journal":{"name":"Supportive Care in Cancer","volume":"33 4","pages":"286"},"PeriodicalIF":2.8,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143634348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"\"It was time I could have spent better\"-the barriers, enablers, and recommendations for improving access to financial aid when a child has cancer.","authors":"Megumi Lim, Christine Cashion, Sameera Senanayake, Susanna Cramb, Sanjeewa Kularatna, Natalie Bradford","doi":"10.1007/s00520-025-09347-3","DOIUrl":"10.1007/s00520-025-09347-3","url":null,"abstract":"<p><strong>Purpose: </strong>A child's cancer diagnosis imposes both short-term and long-term stress on families. This study aimed to explore (1) the barriers and enablers in alleviating the financial impacts of a child's cancer diagnosis and treatment, and (2) areas for improvement in financial aid as suggested by stakeholders.</p><p><strong>Method: </strong>This qualitative study utilised semi-structured interviews with five hospital social work team members, three charity representatives and eight parents of children treated for cancer. The interviews, which were conducted between April 2023 and January 2024, were analysed using content analysis with a deductive-inductive approach supported by Nvivo Software.</p><p><strong>Results: </strong>Barriers to mitigating financial impacts included administrative difficulties (e.g. paperwork complexities, strict eligibility criteria and limited support), psychosocial factors (e.g. cognitive burden, social and societal factors), and navigational issues (e.g. poor communication, fragmented support systems). Enablers included streamlined administrative processes, assistance with navigating and applying for financial aid and community support for emotional refuge and respite. Suggested improvements included simplified application forms, offering automatic provision for certain financial aids upon diagnosis, providing infrastructure to support application processes, reallocating funds to increase navigator roles, providing tailored information through a centralised platform, and facilitating connections to parent support groups. Implications for cancer survivors The financial stress stemming from the uncertainty of a child's cancer diagnosis can be overwhelming. Current support systems fall short in effectively mitigating this stress. This research provides empirical evidence for policy changes to enhance support for families, which is crucial to alleviate the multifaceted challenges they face.</p>","PeriodicalId":22046,"journal":{"name":"Supportive Care in Cancer","volume":"33 4","pages":"284"},"PeriodicalIF":2.8,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11910398/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143634216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of preferences and responses to recall in adolescent and young adult head and neck cancer survivors treated with radiotherapy.","authors":"Alden Chau, A Fuchsia Howard, Karen Goddard, Sarah Nicole Hamilton","doi":"10.1007/s00520-025-09340-w","DOIUrl":"https://doi.org/10.1007/s00520-025-09340-w","url":null,"abstract":"<p><strong>Purpose: </strong>Adolescents and young adult survivors of head and neck cancers are at risk of long-term complications stemming from their diagnosis and treatment. A cross-sectional study was performed on recalled survivors with the objective of reviewing their response to recall and preferences for ongoing care, to determine health service use before recall, and to describe knowledge and information seeking.</p><p><strong>Methods: </strong>Survivors of head and neck cancer diagnosed between the ages 15-39 during the period 1970-2010 and treated with radiotherapy were invited to the survey. Participants were asked to describe their emotions upon being recontacted, including preferences and perceptions of their care.</p><p><strong>Results: </strong>Of the 36 participants, 77% were diagnosed after the age of 30, and 89% diagnosed after 1990. Upon being recontacted, 58% reported feeling happy and 52% feeling surprised. More than three-quarters of participants experienced no anger, fear, worry, or confusion. A total of 71% perceived the adult cancer organization was most responsible for providing updates on health risks post-treatment for their cancer. The most common primary health provider was their regular family doctor at 82%. Regarding control/management of health problems, 46% stated they felt very confident, while 49% stated they were somewhat confident.</p><p><strong>Conclusions: </strong>Patients generally responded positively upon being recalled, with the environment of recall providing a good opportunity for both patient and practitioner to gather information to make informed decisions regarding future care.</p>","PeriodicalId":22046,"journal":{"name":"Supportive Care in Cancer","volume":"33 4","pages":"281"},"PeriodicalIF":2.8,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143630554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"End of life for glioblastoma patients.","authors":"Guido Frosina","doi":"10.1007/s00520-025-09343-7","DOIUrl":"https://doi.org/10.1007/s00520-025-09343-7","url":null,"abstract":"","PeriodicalId":22046,"journal":{"name":"Supportive Care in Cancer","volume":"33 4","pages":"280"},"PeriodicalIF":2.8,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143630509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to: Association between geriatric co‑management and receipt of rehabilitation services in the inpatient postoperative period among older adults with cancer.","authors":"Kiran K Bhurtyal, Amy L Tin, Andrew J Vickers, Armin Shahrokni","doi":"10.1007/s00520-025-09328-6","DOIUrl":"https://doi.org/10.1007/s00520-025-09328-6","url":null,"abstract":"","PeriodicalId":22046,"journal":{"name":"Supportive Care in Cancer","volume":"33 4","pages":"276"},"PeriodicalIF":2.8,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143625016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patient-reported outcomes in head and neck cancer: a cross-sectional analysis of quality of life domains across early and advanced UICC stages.","authors":"Moritz Allner, Atina Rak, Matthias Balk, Robin Rupp, Omar Almajali, Henriette Tamse, Juliane Gschossmann, Matti Sievert, Sarina Müller, Michael Koch, Heinrich Iro, Magdalena Gostian, Markus Hecht, Elisabeth Wimmer, Antoniu-Oreste Gostian","doi":"10.1007/s00520-025-09204-3","DOIUrl":"10.1007/s00520-025-09204-3","url":null,"abstract":"<p><strong>Background: </strong>Head and neck cancer (HNC) patients experience a variety of post-treatment symptoms that affect their quality of life (QoL). This study aims to assess the most prevalent symptoms and their relationship to cancer stage (UICC I-IV) while identifying areas for targeted intervention.</p><p><strong>Methods: </strong>A cross-sectional study was conducted involving 340 HNC patients at the University Hospital Erlangen from January to December 2019. QoL and its domains were assessed using the German version of the University of Washington Quality of Life Questionnaire Version 4 (UW-QoL v.4), with comparisons made between early-stage (UICC I & II, n = 180) and advanced-stage (UICC III & IV, n = 160) patients. Statistical analysis examined differences in QoL and its individual domains.</p><p><strong>Results: </strong>Advanced-stage patients reported significantly greater impairments in several QoL domains, including swallowing (p = 0.003, η² = 0.038), saliva production (p < 0.001, η² = 0.104), and taste (p = 0.009, η² = 0.030), compared to early-stage patients. Psychological symptoms, such as anxiety and mood disturbances, were prevalent across all stages, but no significant differences were found between early- and advanced-stage patients for pain, speech, mood, or anxiety (p > 0.05). Patient demographics, including age, gender, and comorbidities, were similar between groups. The greater impairments in QoL domains observed in advanced-stage patients are likely due to more intensive treatments, such as multimodal therapy and radiochemotherapy.</p><p><strong>Conclusion: </strong>Advanced-stage HNC patients experience a significantly higher burden of physical symptoms, particularly issues with swallowing, saliva, and taste, necessitating early and targeted interventions. Psychological issues are also prevalent and should be addressed in both early- and advanced-stage patients. Despite non-significant differences in some symptoms, their clinical relevance may still be important, particularly in individual cases. Comprehensive care, including physical and emotional support, is essential to improving long-term QoL for HNC patients. Further research should focus on longitudinal assessments and clinically meaningful thresholds for symptom management.</p>","PeriodicalId":22046,"journal":{"name":"Supportive Care in Cancer","volume":"33 4","pages":"278"},"PeriodicalIF":2.8,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11906576/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143625837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dyadic effects of locus of control and coping style on posttraumatic growth in patients with gynecological cancer and their spouses: an actor‒partner interdependence modeling approach.","authors":"Fangli Xiong, Dan Ye, Yuanyuan Song, Xiaolian Jiang","doi":"10.1007/s00520-025-09326-8","DOIUrl":"https://doi.org/10.1007/s00520-025-09326-8","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to examine the dyadic effects of locus of control and coping style on the posttraumatic growth(PTG) of gynecological cancer patients and their spouses via the actor-partner interdependence model (APIM).</p><p><strong>Methods: </strong>This was a prospective cross-sectional survey study. A convenience sampling method was used to select participants. The Demographic and Cancer-related Information Questionnaire, Internality, Powerful others and Chance Scale, Simplified Coping Style Questionnaire and Chinese-Posttraumatic Growth Inventory Scale were utilized for the survey. An actor‒partner interdependence model was constructed to examine the impact of locus of control and coping style on PTG for both patients and their spouses.</p><p><strong>Results: </strong>The date of 400 individuals(200 couples) were analyzed. The PTG scores for patients and their husbands were 61.66 ± 12.82 and 57.77 ± 12.03, respectively. Both partners' PTG was influenced by internal locus of control and positive coping style (P < 0.01). Each partner's internal locus of control and positive coping style could predict their own PTG, with a significant actor effect (P < 0.05). The spouse's internal locus of control could predict the patient's PTG, whereas the patient's positive coping style could predict the spouse's PTG, indicating significant partner effects (P < 0.05).</p><p><strong>Conclusions: </strong>The PTG of gynecological cancer patients and their spouses is moderate. The locus of control and coping style of both partners have an interactive effect on their own PTG. To promote PTG for both partners, healthcare professionals should intervene simultaneously with patients and their spouses, incorporating positive psychological intervention methods.</p>","PeriodicalId":22046,"journal":{"name":"Supportive Care in Cancer","volume":"33 4","pages":"279"},"PeriodicalIF":2.8,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143625739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of triplet antiemetic prophylaxis against chemotherapy-induced nausea and vomiting in patients with soft tissue sarcomas receiving consecutive-day doxorubicin and ifosfamide therapy.","authors":"Yunami Yamada, Hirotoshi Iihara, Akihito Nagano, Hironori Fujii, Masanori Tsugita, Ryo Hoshino, Koki Hara, Ryo Kobayashi, Haruhiko Akiyama, Akio Suzuki","doi":"10.1007/s00520-025-09346-4","DOIUrl":"https://doi.org/10.1007/s00520-025-09346-4","url":null,"abstract":"<p><strong>Background: </strong>Doxorubicin and ifosfamide (AI) therapy for soft tissue sarcomas (STS) is given as a 5-day continuous-dose chemotherapy regimen, and classified as carrying high emetic risk. The purpose of this study was to evaluate the efficacy of triplet antiemetic prophylaxis, consisting of a 5-HT₃ receptor antagonist, dexamethasone (DEX), and an NK₁ receptor antagonist, against chemotherapy-induced nausea and vomiting (CINV) induced by AI therapy, and to determine the prophylactic antiemetic effect of the addition of olanzapine (OLZ) to this triplet antiemetic prophylaxis in cases of poor antiemesis.</p><p><strong>Patients and methods: </strong>Patients who received AI therapy for STS between October 2011 and October 2022 were included in this retrospective study. Patients who did not receive the standard triplet antiemetic prophylaxis of granisetron, DEX, and aprepitant were excluded. Primary endpoint was the rate of complete response (CR) and secondary endpoint was the rate of significant nausea prevention during the acute (days 1-6), delayed (days 7-10), and overall (days 1-10) periods. In addition, CR rate and significant nausea prevention during the acute phase were compared before and after the addition of OLZ in patients who received OLZ as antiemetic prophylaxis in the subsequent cycle due to poor antiemetic control.</p><p><strong>Results: </strong>A total of 58 patients were analyzed. CR rate for all patients was 32.8% in the acute phase, 53.4% in the delayed phase, and 29.3% in the overall period. The significant nausea prevention rate was 19.0%, 43.1%, and 13.8%, respectively. Sixteen patients received additional OLZ as an antiemetic prophylaxis. Their CR rate before and after the addition of OLZ during the acute phase improved significantly, from 6.3 to 43.8% (P = 0.041). The rate of significant nausea prevention tended to improve, from 6.3 to 43.8% (P = 0.077).</p><p><strong>Conclusion: </strong>Control of CINV with granisetron, DEX, and aprepitant was poor in patients with STS receiving AI therapy. Addition of OLZ to this standard triplet antiemetic prophylaxis may improve CINV control in the subsequent cycle in patients who experience inadequate CINV control during their first cycle of AI therapy.</p>","PeriodicalId":22046,"journal":{"name":"Supportive Care in Cancer","volume":"33 4","pages":"274"},"PeriodicalIF":2.8,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143617319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}