Supportive Care in Cancer最新文献

{"title":"Early integration or last consultation: in-house palliative care involvement for hospitalized patients in tertiary medicine-a retrospective analysis.","authors":"Nico Bucklar, Markus Schettle, M Feuz, F Däster, Sebastian M Christ, David Blum, Caroline Hertler","doi":"10.1007/s00520-025-09312-0","DOIUrl":"10.1007/s00520-025-09312-0","url":null,"abstract":"<p><strong>Background: </strong>The importance of timely integration of palliative care has been confirmed over the past years for any patient suffering from a life-threatening or life-limiting disease. Palliative and supportive care increases quality of life of patients and caregivers in both oncological and non-cancer diseases and should therefore be offered on a needs-based approach and throughout the disease trajectory.</p><p><strong>Methods: </strong>We analyzEd all in-patient consultation requests of the leading university hospital in Switzerland in 2019. Sociodemographics, symptoms, and specific requests as well as provided support offers were retrieved from the electronic patient files. Demographic and clinical data was analyzed by descriptive statistics between groups. Overall survival from diagnosis and time from consultation to death was analyzed by means of Kaplan-Meier estimates and log-rank test.</p><p><strong>Results: </strong>We identified 507 in-patient consultation requests from 24 oncological and non-oncological departments in 2019. The final analysis cohort comprised 290 patients, of which 133 women (45.9%). Median overall survival of the population from diagnosis was 21.1 months (CI 15.57-26.72). Median survival from palliative care consultation was 29 days (CI 20.89-37.11), independent of primary diagnosis (p = 0.298) or sex (p = 0.079). A total of 38.9% (N = 140) of consultations were requested concurrently to a tumor-targeted treatment. Palliative care consultations provided more support services than requested (p < 0.001).</p><p><strong>Conclusion: </strong>Our findings underline the persisting late involvement of palliative care services in the disease trajectory, despite being a concurrently consultable and readily available support service to address patient and caregiver needs.</p>","PeriodicalId":22046,"journal":{"name":"Supportive Care in Cancer","volume":"33 4","pages":"251"},"PeriodicalIF":2.8,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11882618/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143568235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characteristics of oral mucositis in patients undergoing haploidentical stem cell transplantation with posttransplant cyclophosphamide: marked difference between busulfan and melphalan regimens.","authors":"Saki Ogura, Yoshihiko Soga, Hideaki Fujiwara, Rumi Miura, Ken-Ichi Matsuoka, Yoshinobu Maeda, Takuo Kuboki","doi":"10.1007/s00520-025-09313-z","DOIUrl":"10.1007/s00520-025-09313-z","url":null,"abstract":"<p><strong>Purpose: </strong>This study was performed to examine the effects of conditioning regimens on oral mucositis in haploidentical (haplo) donor hematopoietic stem cell transplantation (HSCT) with posttransplant cyclophosphamide (PTCy).</p><p><strong>Methods: </strong>Thirty consecutive patients (male, 23; female, 7; 18-68 years, median, 59 years) undergoing haplo-HSCT with PTCy using one of three conditioning regimens-reduced intensity conditioning (RIC)-melphalan (Mel); RIC-Busulfan (Bu); and myeloablative conditioning (MAC)-Bu-were enrolled in this study. Data on the WHO grade of oral mucositis (day - 7 to + 20) were collected retrospectively. The incidences of ulcerative and severe mucositis (Grade 2-4 and Grade 3-4, respectively) were compared between the three groups.</p><p><strong>Results: </strong>Ulcerative mucositis occurred in 0% (0/10) of patients in the RIC-Mel group, 57.1% (4/7) in the RIC-Bu group, and 100% (13/13) in the MAC-Bu group. The differences between the RIC-Mel and RIC-Bu groups and between the RIC-Bu and MAC-Bu groups were significant (all P < 0.05). Severe mucositis occurred in 57.1% (4/7) of patients in the RIC-Bu group and 100% (13/13) of patients in the MAC-Bu group, and the difference was significant (P < 0.05). The rates of ulcerative mucositis (≥ grade 2) and of severe mucositis (≥ grade 3) were significantly higher in the MAC-Bu group than the RIC-Bu group on days 10, 13, 15, and 16 and on days 10, 14, 15, and 16, respectively (all P < 0.05).</p><p><strong>Conclusion: </strong>The risk of oral mucositis in patients undergoing haplo-HSCT with PTCy is highest with the MAC-Bu conditioning regimen, followed by RIC-Bu, and lowest with RIC-Mel.</p>","PeriodicalId":22046,"journal":{"name":"Supportive Care in Cancer","volume":"33 4","pages":"252"},"PeriodicalIF":2.8,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11882729/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143568204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The development and comparative effectiveness of a patient-centered pathology report for breast cancer care: a randomized clinical trial.","authors":"Sara H Javid, Mark R Kilgore, Elizabeth J Austin, Elizabeth U Parker, Rebeca Alvarez, Meghan R Flanagan, Elena G Brewer, Catalina Gibbons, Sarah K Holt, Janie M Lee, Amelia W Donlan, Lauren M DeStefano, John L Gore","doi":"10.1007/s00520-025-09304-0","DOIUrl":"10.1007/s00520-025-09304-0","url":null,"abstract":"<p><strong>Purpose: </strong>Pathology reports contain complex medical terminology that may be confusing or overwhelming for patients newly diagnosed with breast cancer. We evaluated the effectiveness of patient-centered pathology reports (PCPRs), which translate pathology results into patient-friendly language.</p><p><strong>Methods: </strong>Sixty-six participants newly diagnosed with breast cancer were randomized to receive either a PCPR and standard pathology report (intervention arm) or a standard pathology report alone (control arm). Patients were surveyed at initial pathology disclosure and 1 month later to assess breast cancer knowledge and ratings of decisional confidence, conflict, and self-efficacy for treatment decision-making. Knowledge was assessed for four pathology domains independently.</p><p><strong>Results: </strong>Accuracy of breast cancer knowledge across all domains trended higher for the intervention group compared with the control group (66% vs. 50%, p = 0.11); cancer type and surgical margin status knowledge domains exceeded 75% accuracy for the intervention group. No significant differences between groups were observed for patient-reported ratings of communication, decisional conflict, and decision self-efficacy.</p><p><strong>Conclusions: </strong>PCPRs in lay language appeared to improve patients' knowledge of their breast cancer diagnosis, were acceptable to patients and providers, and have the potential to be broadly applied in an effort to improve patient knowledge and improve the patient experience surrounding a breast cancer diagnosis.</p>","PeriodicalId":22046,"journal":{"name":"Supportive Care in Cancer","volume":"33 3","pages":"248"},"PeriodicalIF":2.8,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143558031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perceived changes in health behaviours and body weight in response to a cancer diagnosis among individuals living with and beyond breast, prostate, and colorectal cancer in the UK: a cross-sectional study.","authors":"Francisco Brenes-Castillo, William Goodman, Phillippa Lally, Abi Fisher, Rebecca J Beeken","doi":"10.1007/s00520-025-09305-z","DOIUrl":"10.1007/s00520-025-09305-z","url":null,"abstract":"<p><strong>Purpose: </strong>This study explored perceived changes in health behaviours and body weight following a cancer diagnosis and investigated related sociodemographic and clinical characteristics.</p><p><strong>Methods: </strong>Individuals living with and beyond breast, prostate, or colorectal cancer (N = 5835) completed the 'Health and Lifestyle After Cancer Survey' which explored their perceptions of health behaviour change following a cancer diagnosis. Multinomial logistic regressions were conducted with perceived changes as dependent variables, and sociodemographic and clinical characteristics as independent variables.</p><p><strong>Results: </strong>Approximately half of the participants did not perceive changes in their physical activity, alcohol intake and body weight, and most did not perceive dietary changes. Less than a third of individuals perceived positive health behaviour changes (11.7% increased physical activity, 24.3% healthier diet, and 31.3% decreased alcohol intake), 35.9% perceived decreases in physical activity, and 27.0% perceived increases in body weight, whereas 19.2% perceived decreases in body weight. Individuals with no education, who were unmarried, and with anxiety/depression and pain/discomfort, were more likely to perceive changes in physical activity, body weight, and diet, but in different directions. Participants of younger age were more likely to perceive increases in their physical activity, a healthier diet, and increases in body weight.</p><p><strong>Conclusion: </strong>Following a diagnosis of cancer, a large proportion of individuals perceived that their health behaviours were unchanged. However, some groups of individuals were more likely to perceive positive changes, whereas others were more likely to perceive negative changes, with differences also observed according to the type of health behaviour.</p><p><strong>Implications for cancer survivors: </strong>Participants with no education, who were unmarried, with anxiety/depression and pain/discomfort, may be more at risk of experiencing negative health behaviour changes post-diagnosis. Clinicians should consider targeting health behaviour support to prevent worse outcomes in the long term.</p>","PeriodicalId":22046,"journal":{"name":"Supportive Care in Cancer","volume":"33 3","pages":"247"},"PeriodicalIF":2.8,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11880087/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143558016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Randomised controlled trial of music listening combined with progressive muscle relaxation for mood management in women receiving chemotherapy for cancer.","authors":"Khanh Thi Nguyen, Dorothy N S Chan, Ankie Tan Cheung, Huong Thi Xuan Hoang, Anh Tuan Truong, Ka Ming Chow, Kai Chow Choi, Carmen W H Chan","doi":"10.1007/s00520-025-09281-4","DOIUrl":"10.1007/s00520-025-09281-4","url":null,"abstract":"<p><strong>Aims: </strong>To evaluate the effects of passive music listening combined with progressive muscle relaxation on anxiety, depression, stress, coping, and quality-of-life in women with breast and gynaecological cancers receiving chemotherapy.</p><p><strong>Methods: </strong>This was an assessor-blinded, randomised wait-list controlled trial. A total of 120 participants were randomly allocated into an intervention group or a wait-list control group. The intervention group received an intervention comprising training on passive music listening and progressive muscle relaxation, with once-daily self-practice at home for 3 weeks. The wait-list control group received the same intervention after the outcome assessment at week 6. All outcome data were collected before (T0) and 3 weeks (T1), 6 weeks (T2), and 12 months (T3) after randomisation. A generalised estimating equations model was used to compare the changes in each outcome at different time points. Process evaluation was conducted using data from the patient's self-report forms and interviews.</p><p><strong>Results: </strong>The findings indicated that at T1 and T2, the intervention group's reductions in anxiety were significantly larger than those of the control group. Additionally, the intervention group exhibited significantly better decreases in depression at T2, stress at T1, and dysfunctional coping at T2, and a greater improvement in quality-of-life score at T1 and T2 when compared to the control group. Most of the interviewed participants provided positive feedback on the intervention.</p><p><strong>Conclusions: </strong>The intervention was beneficial for lowering anxiety, depression, and stress and increasing the quality-of-life of women receiving chemotherapy for breast and gynaecological cancers.</p><p><strong>Trial registration: </strong>The trial was prospectively registered with ClinicalTrials.gov on 9 February 2022 (registration number: NCT05262621).</p>","PeriodicalId":22046,"journal":{"name":"Supportive Care in Cancer","volume":"33 3","pages":"245"},"PeriodicalIF":2.8,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11880154/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143543568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aerobic exercise and aromatase inhibitor-associated musculoskeletal symptoms: results of a randomized clinical trial.","authors":"Catherine M Bender, Susan M Sereika, Amanda L Gentry, Yehui Zhu, Monica Wagner, Cheryl Cuglewski, Jennie Duquette, George Grove, Meredith Cummings, Myeong-Ga Cho, Adam M Brufsky, Emilia J Diego, Priscilla F McAuliffe, Anna L Marsland, Yvette P Conley, Kirk I Erickson","doi":"10.1007/s00520-025-09257-4","DOIUrl":"10.1007/s00520-025-09257-4","url":null,"abstract":"<p><strong>Purpose: </strong>Women receiving aromatase inhibitors (AIs) for breast cancer frequently experience musculoskeletal symptoms (AIMS) including joint pain, stiffness, and muscle weakness. Aerobic exercise may reduce AIMS, but the evidence is inconclusive. This investigation examined whether aerobic exercise reduces pain in women with breast cancer.</p><p><strong>Methods: </strong>Pain was a secondary outcome of a randomized controlled trial where postmenopausal women with breast cancer receiving AIs (N = 136) with or without pain were randomized to 6 months of moderate-intensity aerobic exercise (n = 70) or usual care (n = 66). The primary (Brief Pain Inventory severity, interference and worst pain) and secondary (SF-36 Bodily Pain and Breast Cancer Prevention Trial Symptom Checklist Musculoskeletal Pain) pain outcomes were assessed at pre-randomization (T1) and post-intervention (T2). Linear mixed modeling with linear contrasts was used to examine the effect of group assignment on outcomes.</p><p><strong>Results: </strong>Participants were a median = 4.7 months post-breast cancer diagnosis at T1. Group-by-time interactions were observed for pain severity ( <math><mover><mi>x</mi> <mo>¯</mo></mover> </math> = 0.848, 95% confidence interval (CI) = 0.233-1.464), pain interference ( <math><mover><mi>x</mi> <mo>¯</mo></mover> </math> = 0.997, 95% CI = 0.448-1.547), and worst pain ( <math><mover><mi>x</mi> <mo>¯</mo></mover> </math> = 1.371, 95% CI = 0.273-2.461) with significant increases in pain severity, interference, and worst pain in controls, small effect sizes, and no significant changes in the exercise group. We also found that a greater percentage of women in the control group had a clinically significant increase (≥ 2 points) in worst pain (p = 0.024) and pain severity (p = 0.029).</p><p><strong>Conclusion: </strong>Our results suggest that aerobic exercise prevents pain increase and may reduce pain prevalence when initiated early in AI therapy. The trial was registered at Clinical Trials.gov (NCT02793921) on May 20, 2016.</p><p><strong>Key findings: </strong>Moderate-intensity aerobic exercise may prevent increases in pain and reduce pain when initiated early in AI therapy in postmenopausal women with breast cancer. Lack of exercise may be associated with increased over-the-counter pain medication use.</p>","PeriodicalId":22046,"journal":{"name":"Supportive Care in Cancer","volume":"33 3","pages":"244"},"PeriodicalIF":2.8,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143543492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of spirituality and quality of life in cancer survivors: a systematic review and meta-analysis.","authors":"Jenny L Firkins, Ivana Tomic, Lissi Hansen, Christopher D Woodrell","doi":"10.1007/s00520-025-09306-y","DOIUrl":"10.1007/s00520-025-09306-y","url":null,"abstract":"<p><strong>Purpose: </strong>Cancer is a leading cause of morbidity and mortality worldwide. Although people are living longer with cancer, cancer has the potential to impact survivors' quality of life (QOL) negatively. Spirituality encompasses the concepts of transcendence, meaningfulness, faith, connectedness, and integrative energy. Spirituality is a part of everyday existence across cultures and religions and part of the human experience. Yet little has been published on spirituality in cancer survivorship. We could not find any previous reviews that examined the literature on the potential relationship between QOL and spirituality in cancer survivorship. Thus, this systematic review and meta-analysis aim to examine the current literature to more fully understand the relationship between spirituality and QOL.</p><p><strong>Methods: </strong>Using PRISMA guidelines, a systematic review and meta-analysis were conducted to examine the relationship between spirituality and QOL in cancer survivorship in studies sourced from PubMed, CINHAL, and PsycINFO databases.</p><p><strong>Results: </strong>Twenty-six articles published between 2005 and 2024 were included for review. All studies demonstrated a significant, positive correlation between QOL and spirituality, with r values ranging from 0.15 to 0.817.</p><p><strong>Conclusion: </strong>Our findings suggest a positive correlation between higher spirituality and increased QOL among cancer survivors. Future research is needed to improve the understanding of this relationship and its mediators so that supportive oncologic interventions can be modified to address unmet needs and spiritual suffering. By better understanding the relationship between spirituality and QOL, we can move towards supporting the highest level of QOL possible for cancer survivors.</p>","PeriodicalId":22046,"journal":{"name":"Supportive Care in Cancer","volume":"33 3","pages":"246"},"PeriodicalIF":2.8,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143543507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A comparative analysis of the effects of knowledge-attitude-practice nursing on mental state, sleep quality, and self-efficacy in cancer patients.","authors":"Ziqiao Lin, Dong Qi, Yongbo Zhang","doi":"10.1007/s00520-025-09187-1","DOIUrl":"10.1007/s00520-025-09187-1","url":null,"abstract":"<p><strong>Objective: </strong>To explore the effects of knowledge-attitude-practice (KAP) nursing and guided intervention on mental state, sleep quality, and self-efficacy of cancer patients.</p><p><strong>Methods: </strong>Retrospectively, 106 cancer patients were collected and divided into the control (received routine nursing and psychological intervention) and observation groups (given KAP nursing combined guided intervention) following different nursing modalities. The psychological status of patients was evaluated by the Self-rating Anxiety Scale (SAS) and Self-rating Depression Scale (SDS). Disease uncertainty in patients was assessed by Mishel Uncertainty in Illness Scale (MUIS). The quality of life of patients was evaluated by using the short form 36 health survey questionnaire. Sleep quality was evaluated by the Pittsburgh Sleep Quality Index (PSQI). The knowledge level, coping ability, self-efficacy, and satisfaction with nursing work were observed.</p><p><strong>Results: </strong>Following nursing intervention, the scores decreased, with the observation group exhibiting lower scores in SAS, SDS, MUIS, and PSQI. The observation group demonstrated higher levels of cognitive functioning, self-efficacy, and nursing satisfaction and superior coping abilities. The quality of life of both groups after nursing was improved, with the observation group showing a higher score.</p><p><strong>Conclusion: </strong>Guided intervention and KAP nursing can improve the mental status, sleep quality, and self-efficacy of cancer patients.</p>","PeriodicalId":22046,"journal":{"name":"Supportive Care in Cancer","volume":"33 3","pages":"242"},"PeriodicalIF":2.8,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143543468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex-related differences in eating-related distress experienced by patients with advanced cancer.","authors":"Saori Koshimoto, Koji Amano, Jane B Hopkinson, Satomi Okamura, Tatsuma Sakaguchi, Sayaka Arakawa, Akihiro Tokoro, Naoharu Mori, Junko Nozato, Tetsuji Iriyama, Shingo Sato, Takashi Takeuchi","doi":"10.1007/s00520-025-09302-2","DOIUrl":"10.1007/s00520-025-09302-2","url":null,"abstract":"<p><strong>Background: </strong>Sex-related differences in eating-related distress (ERD) experienced by cancer patients have not previously been clarified.</p><p><strong>Methods: </strong>We conducted a multicenter survey among advanced cancer patients referred to palliative care. Data on patient characteristics were collected from the electronic medical records, and data on measurement outcomes were obtained from a questionnaire. Patients were categorized into male and female groups. We measured ERD using the Questionnaire for Eating-Related Distress among Patients with advanced cancer (QERD-P). The QERD-P comprises 3 items in each of the 7 factors, for a total of 21 items, and each item is rated on a 7-point Likert scale. High scores indicate worse distress. Comparisons were calculated using the Mann-Whitney U test. To assess associations between sexes and ERD, multivariate logistic regression analysis was performed.</p><p><strong>Results: </strong>A total of 192 patients were enrolled and divided into the male (n = 92) and female (n = 100) groups. The total score of the QERD-P was significantly higher in the male group (p = 0.018). The subtotal scores of \"reasons why I cannot eat,\" \"insufficient information,\" and \"arguments with my family\" were significantly higher in the male group (p = 0.035, 0.032, and 0.003, respectively). The male group had significantly higher risks for ERD associated with \"arguments with my family\" and \"time with my family\" (odds ratio [OR] 2.69, 95% confidence interval [CI] 1.38-5.24; OR 2.28, 95% CI 1.15-4.53).</p><p><strong>Conclusions: </strong>Males had significantly worse ERD and were at higher risk of ERD in family relationships than females.</p>","PeriodicalId":22046,"journal":{"name":"Supportive Care in Cancer","volume":"33 3","pages":"241"},"PeriodicalIF":2.8,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143537753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Opioid conversion in adults with cancer: MASCC-ASCO-AAHPM-HPNA-NICSO guideline.","authors":"Mellar P Davis, Andrew Davies, Mary Lynn McPherson, Akhila S Reddy, Judith A Paice, Eric J Roeland, Declan Walsh, Sebastiano Mercadante, Amy A Case, Robert M Arnold, Eriko Satomi, Gregory Crawford, Eduardo Bruera, Kari Bohlke, Carla Ripamonti","doi":"10.1007/s00520-025-09286-z","DOIUrl":"10.1007/s00520-025-09286-z","url":null,"abstract":"<p><strong>Purpose: </strong>To standardize and improve the safety and efficacy of opioid conversion in people with cancer.</p><p><strong>Methods: </strong>The Multinational Association of Supportive Care in Cancer (MASCC), American Society of Clinical Oncology (ASCO), American Academy of Hospice and Palliative Medicine (AAHPM), Hospice and Palliative Nurses Association (HPNA), and Network Italiano Cure di Supporto in Oncologia (NICSO) convened an Expert Panel to develop recommendations based on a systematic review of the literature and a formal consensus process. The systematic review focused on randomized and non-randomized studies published from database inception to June 2022. A modified Delphi approach was used to develop and finalize recommendations. Recommendations developed by the Expert Panel underwent two rounds of consensus voting before being finalized.</p><p><strong>Results: </strong>The systematic review, published separately, identified 208 eligible studies. These studies provided mixed and inclusive findings regarding optimal approaches to opioid conversion. In consensus voting, 58 of 84 statements met or exceeded the required 75% level of agreement and were accepted. This process demonstrated some consistencies in conversion ratios between particular opioids internationally, but also uncovered variability in opioid conversion ratios among experts, particularly for methadone.</p><p><strong>Recommendations: </strong>The recommendations address three main topics: pre-conversion assessments, strategies for conversion, and post-conversion assessments. The goal is to reduce the relative risk of overdosing or under-dosing opioids when converting from one opioid to another or converting administration routes. The strength of the evidence from the trials is modest, and there are large clinical practice and research gaps. The panel hopes this guideline will establish an international best practice baseline that can be built upon by new research and better-designed trials. Additional information is available at www.asco.org/supportive-care-guidelines .</p>","PeriodicalId":22046,"journal":{"name":"Supportive Care in Cancer","volume":"33 3","pages":"243"},"PeriodicalIF":2.8,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143543510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}