Supportive Care in Cancer最新文献

{"title":"A qualitative case study of body image in women with breast cancer participating in an exercise program.","authors":"Pau Mateu, Clara Teixidor-Batlle, María-Pilar Suárez-Alcázar, Pablo Salas-Medina, Ignacio Catalá-Vilaplana, Carlos Hernando-Domingo, María Muriach, Eladio Collado-Boira","doi":"10.1007/s00520-025-09963-z","DOIUrl":"10.1007/s00520-025-09963-z","url":null,"abstract":"<p><strong>Purpose: </strong>To analyze the body image perceptions of female breast cancer patients who took part in a physical exercise (PE) program.</p><p><strong>Methods: </strong>Four discussion groups were held with 40 breast cancer patients participating in an exercise program. Hierarchical content analysis identified three central themes: (a) consequences of cancer, (b) coping, and (c) consequences of exercise.</p><p><strong>Results: </strong>Regarding cancer consequences, narratives linked to the others' perception and body stigma prevailed. Participants used mutual support and empowerment as their main coping strategies. The PE program was perceived as a promoter of physical (functional and aesthetic) and psychological benefits.</p><p><strong>Conclusions: </strong>The participation of female breast cancer patients in PE programs contributes to greater physical, psychological, and social well-being. The analyzed PE program contributed, in general, to an improvement in body image with special emphasis on body function and in cognitive and affective dimensions.</p><p><strong>Implications for cancer survivors: </strong>PE programs can be a valuable intervention for breast cancer survivors, enhancing body image, quality of life, and emotional resilience during recovery.</p>","PeriodicalId":22046,"journal":{"name":"Supportive Care in Cancer","volume":"33 10","pages":"893"},"PeriodicalIF":3.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12488808/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145201209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to: Oral health‑related quality of life among long‑term head and neck cancer survivors: a multinational study.","authors":"Kristine Løken Westgaard, Cecilie Delphin Amdal, Katherine J Taylor, Ragnhild Sørum Falk, Kristin Bjordal, Susanne Singer, Eva Hammerlid, Max Krüger, Carmen Stromberger, Orlando Guntinas-Lichius, Fréderic Duprez, Noa Stempler, Noam Yarom, Erofili Papadopoulou, Bente Brokstad Herlofson","doi":"10.1007/s00520-025-09991-9","DOIUrl":"10.1007/s00520-025-09991-9","url":null,"abstract":"","PeriodicalId":22046,"journal":{"name":"Supportive Care in Cancer","volume":"33 10","pages":"894"},"PeriodicalIF":3.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12488820/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145201363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating the role of montelukast on doxorubicin-induced cardiotoxicity in breast cancer patients.","authors":"Naglaa F Gomaa, Rehab H Werida, Ahmed G El-Gowily, Noha A El-Bassiouny","doi":"10.1007/s00520-025-09947-z","DOIUrl":"10.1007/s00520-025-09947-z","url":null,"abstract":"<p><strong>Purpose: </strong>Doxorubicin (DOX), a prominent anthracycline, is used to treat malignancies, but its cardiotoxicity restricts its therapeutic application. This study examined the potential protective effects of montelukast (ML), an anti-asthmatic drug with anti-inflammatory characteristics, against doxorubicin-induced cardiotoxicity (DIC) in breast cancer (BC) patients.</p><p><strong>Method: </strong>A prospective, randomized, controlled clinical study including fifty individuals with a confirmed diagnosis of BC, individuals scheduled to receive DOX 60 mg/m² in conjunction with Cyclophosphamide 600 mg/m² (AC) for four courses at 21-day intervals. Both the control group and the ML group were randomly selected from the patient pool.</p><p><strong>Results: </strong>After treatment, a significant reduction in N-terminal Pro Brain Natriuretic Peptide (NT pro-BNP) levels was observed in the ML group compared to the control group (1756.0 [1054.0-2334.0] vs. 3788.0 [2226.0-4401.1] pg/mL, p < 0.001). Nuclear factor-kappa B (NF-κB) levels also decreased significantly in the ML group (2.23 [1.18-3.05] vs. 3.11 [2.39-3.25] pg/mL, p = 0.009). The median percentage reduction in Soluble suppression of tumorigenicity 2 (sST2) levels was more pronounced in the ML group (20.93 ± 5.45 ng/mL) than in the control group (24.16 ± 5.14 ng/mL, p = 0.036). Additionally, a strong positive correlation between NT pro-BNP and NF-κB levels was observed post-treatment (rs = 0.644, p < 0.001), supporting ML's potential anti-inflammatory and cardioprotective effects.</p><p><strong>Conclusion: </strong>The incorporation of ML into AC led to a substantial decrease in cardiac biomarkers confirming the feasibility of incorporating ML in individuals with breast cancer as an auxiliary treatment to prevent DOX-induced cardiotoxicity. Trial registration ClinicalTrials.gov: NCT05959889.</p>","PeriodicalId":22046,"journal":{"name":"Supportive Care in Cancer","volume":"33 10","pages":"897"},"PeriodicalIF":3.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12488768/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145207618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the editor: Unmet needs and emotional well-being of family caregivers of adult patients with cancer.","authors":"Kohei Kajiwara, Maki Kanaoka, Jun Kako, Masamitsu Kobayashi, Yasuhide Etou, Teppei Yamashita, Makoto Yamanaka","doi":"10.1007/s00520-025-09983-9","DOIUrl":"10.1007/s00520-025-09983-9","url":null,"abstract":"","PeriodicalId":22046,"journal":{"name":"Supportive Care in Cancer","volume":"33 10","pages":"895"},"PeriodicalIF":3.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145201304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effects of staged sexual health education on sexual and mental health in breast cancer patients: a randomized controlled study.","authors":"Rongfei Suo, Fulan Li, Mengjun Liu, Jiajun Quan, Xiao Chen, Lirong Yang, Fenglian Ye","doi":"10.1007/s00520-025-09929-1","DOIUrl":"10.1007/s00520-025-09929-1","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to assess the impact of staged sexual health education on improving the sexual and mental health of patients with breast cancer.</p><p><strong>Methods: </strong>This was a randomized controlled trial (RCT). A total of 94 patients with breast cancer were assigned to the control or intervention group, which received standard and staged sexual health education, respectively. The Quality of Sexual Life Questionnaire (QSL), Female Sexual Function Index (FSFI), Self-rated Depression Scale (SDS), and Self-rated Anxiety Scale (SAS) were used to assess the sexual and mental health status of patients with breast cancer before (T1) and after the intervention (T2, T3). Repeated-measures Analysis of Variance (ANOVA) was used to compare the differences in outcome scale scores between the groups at each time point.</p><p><strong>Results: </strong>The QSL scores in the intervention group were significantly higher than those in the control group at T3 (P < 0.05). The FSFI scores in the intervention group were significantly higher than those in the control group at both T2 and T3 (P < 0.05). Furthermore, the proportion of patients who resumed sexual activity in the intervention group (85.4%) was significantly greater than that in the control group (40.5%) (P < 0.001). However, no significant differences in the SDS or SAS scores were noted between the intervention and control groups at T2 or T3 (P > 0.05).</p><p><strong>Conclusion: </strong>Staged sexual health education can help patients with breast cancer correctly understand their sexual health-related knowledge, restore their normal sexual life, and improve their FSFI and QSL.</p>","PeriodicalId":22046,"journal":{"name":"Supportive Care in Cancer","volume":"33 10","pages":"891"},"PeriodicalIF":3.0,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145201426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Physical activity in people affected by head and neck cancers: gender-specific barriers and preferences-ORLAPA survey results.","authors":"Joey Martin, Timothee Marchal, Nolween Badier, Carole Bouleuc, Christophe Le Tourneau, Nathalie Badois, Maria Lesnik, Rabah Taouachi, Antoine Dubray-Vautrin, Wahib Ghanem, Juliette Quarez, Baptise Sabran, Olivier Choussy, Lidia Delrieu","doi":"10.1007/s00520-025-09908-6","DOIUrl":"10.1007/s00520-025-09908-6","url":null,"abstract":"<p><strong>Purpose: </strong>People with head and neck cancers (HNCs) often experience deconditioning, nutritional challenges, and low adherence to physical activity (PA) guidelines. While gender influences PA behaviors in other cancers, data among HNC survivors remain limited. We investigated gender-specific differences in PA preferences, perceived barriers, and interest in nutrition education among French HNC patients.</p><p><strong>Methods: </strong>In June 2023, 400 adult HNC patients at a French cancer center were invited to complete a 24-item online survey assessing sociodemographics, digital device use, PA preferences (modality, intensity, frequency, supervision, duration, social context, location), perceived barriers, and willingness to join a nutrition-integrated education program. Gender differences were analyzed using chi-square/Fisher's exact tests and t-tests.</p><p><strong>Results: </strong>Eighty-nine respondents (mean age 62.1 ± 11.5 years; 68.5% male) were included. Seventy-three percent expressed interest in a tailored PA program, and 70.8% felt physically able to participate. Walking was the most preferred activity (80.9%), with moderate intensity, 30-60-min sessions twice weekly. Men favored independent, home- or outdoor-based activities (e.g., biking: 52.5% vs. 21.4% in women; p = 0.02) and exercising alone, while women preferred group-based, supervised formats (e.g., yoga/dance: 53.6% vs. 21.3%; p = 0.002) and showed greater interest in nutrition education (60.7% vs. 13.1%; p < 0.001). Fatigue and lack of motivation were the most common barriers (36%).</p><p><strong>Conclusion: </strong>Distinct gender-specific patterns in PA and educational preferences exist among HNC survivors. Men may benefit most from autonomous, home- or outdoors-based PA programs, while women appear to engage more readily with supervised, socially interactive formats including targeted nutritional guidance.</p>","PeriodicalId":22046,"journal":{"name":"Supportive Care in Cancer","volume":"33 10","pages":"892"},"PeriodicalIF":3.0,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12484345/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145201364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PanSupport: a community model of cancer supportive care provision.","authors":"Melanie Regan, Amy Larsen","doi":"10.1007/s00520-025-09962-0","DOIUrl":"10.1007/s00520-025-09962-0","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to describe the type and extent of supportive care interventions provided by PanSupport, a community-based telehealth service providing supportive care for people impacted by upper gastrointestinal cancer in Australia.</p><p><strong>Methods: </strong>A qualitative research design employing thematic and content analysis of written data was used to categorise and describe interactions with 30 patients and 10 carers during a 3-month period in 2023. Purposive sampling to obtain information-rich interactions was employed.</p><p><strong>Results: </strong>PanSupport undertakes a variety of activities that support patients and carers in the community. The activities are supported by the literature on cancer supportive care. The approaches, categories and definitions of care described in this telehealth model are consistent with the breadth of services provided to patients in non-telehealth/hospital-based models of care.</p><p><strong>Conclusions: </strong>The community-based telehealth model of supportive care described provides care consistent with service provision across the traditional multidisciplinary cancer care spectrum. This paper outlines the expertise and interventions such a model can provide and offers a foundation for further refinements and developments.</p>","PeriodicalId":22046,"journal":{"name":"Supportive Care in Cancer","volume":"33 10","pages":"890"},"PeriodicalIF":3.0,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12484364/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145201388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Strategies for premedication and G-CSF application in sacituzumab govitecan treatment of patients with triple-negative breast cancer: multicenter insights.","authors":"Małgorzata Pieniążek, Anna Polakiewicz-Gilowska, Marcin Kubeczko, Manuela Las-Jankowska, Renata Pacholczak-Madej, Paulina Kilian-Van Miegem, Marek Ziobro, Aleksandra Łacko, Michał Jarząb, Miroslawa Püsküllüoğlu","doi":"10.1007/s00520-025-09918-4","DOIUrl":"10.1007/s00520-025-09918-4","url":null,"abstract":"<p><strong>Background: </strong>Sacituzumab govitecan (SG) is approved for advanced triple-negative breast cancer (TNBC) in the second-line setting and beyond, offering improved survival compared to chemotherapy. Adverse events (AEs) commonly include myelosuppression, gastrointestinal disturbances, and hepatic toxicity. Effective premedication and prophylaxis are critical for AE management. This study assessed premedication protocols for SG-treated TNBC patients.</p><p><strong>Materials and methods: </strong>A retrospective cohort study across five oncology centers in Poland analyzed premedication regimens for patients completing SG treatment by October 2024. Premedication evaluated included acetaminophen, corticosteroids, antihistamines, 5-HT3 and NK1 receptor antagonists, and granulocyte colony-stimulating factor (G-CSF) when needed. AEs were assessed using National Cancer Institute-Common Terminology Criteria for Adverse Events, version 5.0.</p><p><strong>Results: </strong>Among 67 patients with TNBC who finished their treatment with SG, the mean age at SG initiation was 51.5 ± 12.4 years. Premedication in the first cycle included corticosteroids and 5-HT3 receptor antagonists in 66 (99%) and 65 (97%) patients, respectively; acetaminophen in 57 patients (85%), H1 blockers in 53 patients (79%), and H2 blockers in 52 patients (78%). G-CSF was used as primary prophylaxis in 27 patients (40%) and required in 53 patients (79%) during treatment. Atropine premedication was needed in 4 patients (6%) for grade 3 diarrhea as secondary prophylaxis.</p><p><strong>Conclusions: </strong>Most patients received standardized premedication regimens, but significant variability was observed in G-CSF use for neutropenia prophylaxis. Only 6% of patients required atropine as diarrhea premedication. Practices regarding the use of G-CSF varied across centers, reflecting evolving SmPC guidance and individual risk-based approaches to neutropenia management.</p>","PeriodicalId":22046,"journal":{"name":"Supportive Care in Cancer","volume":"33 10","pages":"889"},"PeriodicalIF":3.0,"publicationDate":"2025-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12477073/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145186806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adapting an in-person acceptance and commitment therapy-based psychological intervention for fear of cancer recurrence into a digital format: a real-world evaluation during the COVID-19 pandemic.","authors":"Fiona Sinclair, David Gillanders, Christopher Hewitt, Natalie Rooney, Christine Bonathan, Lauren McAllister, Marta Correia, Lynsey Devlin, Kirsty Hendry","doi":"10.1007/s00520-025-09946-0","DOIUrl":"10.1007/s00520-025-09946-0","url":null,"abstract":"<p><strong>Purpose: </strong>Service evaluation comparing the effectiveness and acceptability of an in-person and a digitally delivered acceptance and commitment therapy (ACT)-based group programme for fear of cancer recurrence (FCR) for breast cancer survivors.</p><p><strong>Methods: </strong>The programme was designed and delivered as part of a real-world, supportive care intervention and adapted for digital delivery in response to COVID-19 pandemic restrictions. FCR, quality of life (QoL), psychological flexibility, and psychological distress measures were routinely collected pre-participation, post-participation, and 12 weeks following completion.</p><p><strong>Results: </strong>Ninety-seven in-person and 61 digital participants completed the group programme. Uptake was 30% and retention 89% for in-person. Uptake was 23% and retention 64% for online referrals. Between group statistical analyses revealed non-significant differences between delivery modality on overall scores of FCR (p = 0.76), QoL (p = 0.06) and psychological distress (anxiety p = 0.16; depression p = 0.22). There was a significant difference in psychological flexibility scores (p = 0.04); digital participant scores were higher (mean = 83) than in-person participants (mean = 76.3). Within-group statistical analyses found a significant effect of time for all outcome measures, with a significant decrease in FCR and psychological distress and a significant increase in QoL and psychological flexibility (p < 0.001 for all measures). There were no statistically significant interaction effects between delivery modality and timepoint.</p><p><strong>Conclusion: </strong>In-person and online delivery of a real-world FCR group programme offered to breast-cancer survivors was found to be beneficial and comparable. These results support the potential benefits of a flexible approach to delivery modality of supportive care interventions. Further investigation is required to determine if these results are replicable within diverse populations.</p>","PeriodicalId":22046,"journal":{"name":"Supportive Care in Cancer","volume":"33 10","pages":"888"},"PeriodicalIF":3.0,"publicationDate":"2025-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12476442/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145182259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of Orem's self-care model nursing combined with nutritional intervention in postoperative patients with colorectal cancer.","authors":"Xiaoxia Zhu, Shan Zhao, Rui Tang, Qin Xu, Linxia Xu, Yejiang Zhou, Daiying Zhang","doi":"10.1007/s00520-025-09944-2","DOIUrl":"10.1007/s00520-025-09944-2","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to evaluate the effectiveness of Orem's self-care model combined with nutritional intervention in postoperative patients with colorectal cancer (CRC).</p><p><strong>Methods: </strong>Eighty-four postoperative CRC patients were enrolled and randomly divided into a control group (n = 42) or an observation group (n = 42). The control group received routine postoperative care, while the observation group received additional nursing based on Orem's self-care model plus nutritional intervention. Clinical indicators, including serum prealbumin (PA), albumin (ALB), total protein (TP), and body mass index (BMI), were compared between groups before and after care. Anxiety and depression were assessed using the Self-Rating Anxiety Scale (SAS) and Self-Rating Depression Scale (SDS). Self-care agency and quality of life were measured using the Exercise of Self-Care Agency (ESCA) Scale and the Comprehensive Oncology Health Outcome Scale-Quality of Life (COH-QOL-OQ). Patient satisfaction with care was also compared between groups.</p><p><strong>Results: </strong>The observation group achieved shorter times to first flatus, first oral intake, and first ambulation, and shorter hospital stay compared to the control group (P < 0.05). After nursing, PA, ALB, TP, and BMI increased significantly in both groups, with higher levels in the observation group (P < 0.05). SAS and SDS scores were decreased in both groups, with lower values in the observation group (P < 0.05). ESCA and COH-QOL-OQ scores increased in both groups, with great improvements in the observation group (P < 0.05). Patient satisfaction was higher in the observation group (95.24%) than in the control group (73.81%) (P < 0.05).</p><p><strong>Conclusion: </strong>Orem's self-care model combined with nutritional intervention accelerates postoperative recovery, improves nutritional status, alleviates negative emotions, enhances self-care ability, and improves quality of life in CRC patients, thereby increasing patient satisfaction with care.</p>","PeriodicalId":22046,"journal":{"name":"Supportive Care in Cancer","volume":"33 10","pages":"886"},"PeriodicalIF":3.0,"publicationDate":"2025-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145178642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}