Supportive Care in Cancer最新文献

{"title":"Research hotspots and trends in cancer rehabilitation: a bibliometric analysis (2013-2023).","authors":"Ruijuan Cai, Hongsheng Lin, Qiyuan Mao, Chuchu Zhang, Ying Tan, Qianwen Cheng","doi":"10.1007/s00520-025-09355-3","DOIUrl":"10.1007/s00520-025-09355-3","url":null,"abstract":"<p><strong>Background: </strong>Advances in medical care have made cancer rehabilitation an essential component of comprehensive cancer treatment. However, bibliometric analyses in this field remain limited. This study maps the global research landscape of cancer rehabilitation over the past decade.</p><p><strong>Methods: </strong>Relevant publications on cancer rehabilitation from 2013 to 2023 were retrieved from the Web of Science Core Collection (WoSCC) database. Bibliometric analysis was conducted using VOSviewer, CiteSpace, and the R package \"Bibliometrics.\"</p><p><strong>Results: </strong>A total of 6743 publications from 98 countries demonstrated sustained growth, peaking in 2022. The USA (1581 publications) and China (974) led in research output, while the Netherlands recorded the highest citation impact (32.75 citations per paper). Key institutions included the University of Texas MD Anderson Cancer Center (148 publications) and Memorial Sloan Kettering Cancer Center (40.58 citations per paper). Supportive Care in Cancer ranked as the most influential journal. Research efforts primarily focused on exercise interventions (n = 404), quality of life (n = 688), and breast cancer rehabilitation (n = 440). Recent trends highlighted telemedicine, digital health, and breast cancer-related lymphedema.</p><p><strong>Conclusion: </strong>This analysis highlights the dominance of high-income countries in cancer rehabilitation research and identifies exercise, quality of life, and breast cancer as enduring focal points. Emerging priorities include technology-driven interventions and lymphedema management. However, critical gaps remain, such as the underrepresentation of low-resource regions, limited focus on pediatric populations, and insufficient integration of advanced technologies (e.g., AI, wearables). Future efforts should emphasize equitable resource distribution, evidence-based pediatric rehabilitation models, and scalable technology-driven solutions to address global disparities and improve survivorship care.</p>","PeriodicalId":22046,"journal":{"name":"Supportive Care in Cancer","volume":"33 4","pages":"296"},"PeriodicalIF":2.8,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11919980/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143658679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Physical activity, health-related fitness, and physical performance in children with acquired hypothalamic dysfunction.","authors":"I M A A Van Roessel, J Van Schaik, L B Kleinlugtenbelt, S N van Duijn, M Burghard, T Takken, W J E Tissing, W P Bekkering, H M van Santen","doi":"10.1007/s00520-025-09361-5","DOIUrl":"10.1007/s00520-025-09361-5","url":null,"abstract":"<p><strong>Purpose: </strong>Survivors of a pediatric suprasellar tumor may suffer from hypothalamic-pituitary dysfunction (HD), which may result in hypothalamic obesity (HO). The first step in HO treatment is lifestyle intervention (e.g. exercise). Our aim was to assess physical activity (PA), health-related fitness (HRF) and physical performance (PP) in a cohort of children with a suprasellar tumor.</p><p><strong>Methods: </strong>Retrospective study on a national cohort including all children with a suprasellar tumor who were referred to the physiotherapy department 2018-2022. Data was collected on: PA defined as minutes of Moderate-to-Vigorous Physical Activity (MVPA) and number of steps per day, HRF defined as body composition, VO₂peak percentage of predicted, mean power, and muscle strength, and PP based on the 10-m walk and run test, time up and down the stairs, and time to rise from the floor.</p><p><strong>Results: </strong>Seventy-three children (mean age 11.09, mean body mass index SDS 2.36) were evaluated. In total, 24.1% reached the guideline of ≥ 60 min MVPA per day. The VO₂peak percentage of predicted was 71.0% [IQR 57.0 - 82.8] and in 58.3% mean power was ≤ -2 SDS. Muscle strength was not decreased (median of -0.5 SDS). PP was found to be better than the norm. CONCLUSION AND KEY FINDINGS: PA and HRF are decreased in children with HD, however PP was not decreased. This implies that no PP restrictions are present to engage in PA and that a lifestyle coach can be involved to improve PA and HRF in these children.</p>","PeriodicalId":22046,"journal":{"name":"Supportive Care in Cancer","volume":"33 4","pages":"295"},"PeriodicalIF":2.8,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11920002/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143658678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Determinants of healthy lifestyle behaviours in colorectal cancer survivors: a systematic review.","authors":"Judith de Vries-Ten Have, Renate M Winkels, Sharon A G Bloemhof, Annelot Zondervan, Iris Krabbenborg, Ellen Kampman, Laura H H Winkens","doi":"10.1007/s00520-025-09315-x","DOIUrl":"10.1007/s00520-025-09315-x","url":null,"abstract":"<p><strong>Purpose: </strong>Identifying and selecting determinants of health behaviours is an important step in the design of behaviour change interventions. Many colorectal cancer (CRC) survivors experience disease- and treatment-related complaints, which may make it difficult to implement behavioural changes. In this systematic review, we aimed to identify determinants of a healthy lifestyle, i.e. dietary behaviours and physical activity, in CRC survivors who finished treatment.</p><p><strong>Methods: </strong>We searched Web of Science, PubMed and PsychINFO, to retrieve quantitative and qualitative studies on determinants of a healthy lifestyle in CRC survivors who finished treatment. Synonyms of the following search terms were used: 'CRC survivors', 'lifestyle', 'physical activity', 'nutrition' and 'determinant'. The level of evidence for each determinant was classified as 'convincing', 'moderately convincing' or 'unconvincing' based on consistency of findings between studies and quality of studies assessed with the Mixed Methods Appraisal tool.</p><p><strong>Results: </strong>Twenty-one studies were retrieved of which twenty were classified as 'high-quality studies' and one as 'low-quality study'. Determinants that were convincingly associated with less healthy lifestyle behaviours were smoking, depression, body image distress/consciousness, experiencing pain, dealing with symptoms and bad health status. A good functional status was convincingly associated with more healthy lifestyle behaviours. Determinants with convincing evidence for an association with less or more healthy lifestyle behaviours were time and other priorities, knowledge, motivation, (false) beliefs, perceived and expected outcomes, skills, social support, social norms and influence, access to facilities and equipment and weather.</p><p><strong>Conclusion: </strong>Interventions for changing health behaviours in CRC survivors who finished treatment could use these determinants to tailor and personalize the intervention to the target group.</p>","PeriodicalId":22046,"journal":{"name":"Supportive Care in Cancer","volume":"33 4","pages":"292"},"PeriodicalIF":2.8,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11914313/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143650901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Temporal trends in time toxicity of R-CHOP: a nationwide hospital-based database analysis in Japan.","authors":"Hiroaki Araie, Tomohisa Seki, Akira Okada, Toshimasa Yamauchi, Masaomi Nangaku, Takashi Kadowaki, Kazuhiko Ohe, Takahiro Yamauchi, Satoko Yamaguchi","doi":"10.1007/s00520-025-09335-7","DOIUrl":"10.1007/s00520-025-09335-7","url":null,"abstract":"<p><strong>Purpose: </strong>While the prognosis of patients with cancer has improved, the time burden of treatment has recently been recognized as time toxicity; although, the actual clinical situation remains largely unexplored. This retrospective study aimed to elucidate the time toxicity of rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) in patients with B-cell lymphoma and the factors influencing it.</p><p><strong>Methods: </strong>We used a nationwide hospital-based database between January 2010 and November 2021 in Japan. We extracted the claims data of patients with diffuse large B-cell lymphoma and follicular lymphoma who were hospitalized and/or visited hospitals for chemotherapy.</p><p><strong>Results: </strong>Among the 7760 R-CHOP administered to 2006 patients, the rate of outpatient therapy increased over time (2010-2015: 17.9%; 2016-2021: 31.8%). In 2016, the median length of hospitalization was the shortest at 13 days (IQR 8-19), which coincided with the peak use of pegylated granulocyte colony-stimulating factor (Peg-G-CSF) during hospitalization in 2015-2016, likely driven by changes in the insurance system. In multivariate analysis, the factors associated with longer hospital stays were older age and poor activities of daily living, whereas the use of Peg-G-CSF, a reduced-dose regimen, and treatment at cancer-designated hospitals were associated with shorter stays.</p><p><strong>Conclusion: </strong>The time toxicity of R-CHOP has improved and may be influenced by the patient's condition, adequate supportive care, changes in the insurance system, and center-specific treatment proficiency.</p>","PeriodicalId":22046,"journal":{"name":"Supportive Care in Cancer","volume":"33 4","pages":"293"},"PeriodicalIF":2.8,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11913952/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143650600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dietitians' practices and perspectives of the delivery of nutritional care to cancer survivors in the primary care setting.","authors":"Henriette G Ryding, Roshan R Rigby, Elizabeth A Johnston, Rozanne Kruger, Lana J Mitchell","doi":"10.1007/s00520-025-09330-y","DOIUrl":"10.1007/s00520-025-09330-y","url":null,"abstract":"<p><strong>Purpose: </strong>The number of people living longer after a cancer diagnosis is increasing. Guidelines for cancer survivorship recommend a healthy diet and maintaining a healthy weight post-treatment. While cancer survivors often express the need for professional support for nutrition management, few report seeing a dietitian. This study aimed to explore primary care dietitians' experiences, practices, and perspectives in providing nutritional care to cancer survivors in Australia.</p><p><strong>Methods: </strong>This qualitative study used in-depth, semi-structured interviews with primary care dietitians working in private practice and community care. Interviews were recorded and transcribed. A qualitative descriptive methodological approach integrated with a working analytical framework was utilized for coding and data analysis.</p><p><strong>Results: </strong>Twenty-four dietitians working in primary care participated. Four themes and 13 sub-themes were identified: (1) diversity in dietetic practice and cancer-related care interactions; (2) accessing referral pathways and funding sources in a complex healthcare system; (3) the application of nutrition education, and upskilling in cancer care; (4) client barriers and dietitians' challenges and factors influencing confidence in cancer care.</p><p><strong>Conclusion: </strong>Dietitians in this study highlighted the need for clear referral pathways to primary care particularly as a continuation of cancer-related care following the acute setting. There is a need for tailored support for dietitians supporting people diagnosed with cancer in the primary care setting, including opportunities to upskill in cancer care.</p>","PeriodicalId":22046,"journal":{"name":"Supportive Care in Cancer","volume":"33 4","pages":"290"},"PeriodicalIF":2.8,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11913905/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143650219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Research on preventing low anterior resection syndrome following sphincter-preserving surgery for rectal cancer through high-risk screening and pelvic floor biofeedback therapy.","authors":"Wei Wang, Yulian Cai, Jie Peng, Liping Liu, Xiaomei Feng, Shuqin Wan","doi":"10.1007/s00520-025-09358-0","DOIUrl":"https://doi.org/10.1007/s00520-025-09358-0","url":null,"abstract":"<p><strong>Purpose: </strong>This study aims to evaluate the effectiveness of high-risk screening combined with pelvic floor biofeedback therapy in preventing low anterior resection syndrome (LARS) after sphincter-preserving surgery (SPS) for rectal cancer.</p><p><strong>Methods: </strong>Forty-three patients who underwent SPS for rectal cancer at Jiangxi Cancer Hospital from January to December 2022 were assigned to the standard care group and received standard care plus pelvic floor biofeedback therapy. Forty-nine patients treated from January to December 2023 were designated as the high-risk screening group and received high-risk screening for LARS in addition to the standard care group's treatment protocol. LARS scores and incidence rates at 1, 3, and 6 months postoperatively, anorectal pressure values, quality of life scores at 3 and 9 months, and treatment adherence were compared between the two groups.</p><p><strong>Results: </strong>The high-risk screening group showed significantly lower LARS scores and incidence rates at all postoperative intervals compared to the standard care group. Additionally, the high-risk screening group demonstrated better anorectal pressure and quality of life scores and achieved higher treatment adherence, with statistically significant differences between groups (p < 0.05).</p><p><strong>Conclusions: </strong>High-risk screening combined with targeted pelvic floor biofeedback therapy following SPS for rectal cancer can effectively prevent LARS and improve postoperative recovery quality.</p>","PeriodicalId":22046,"journal":{"name":"Supportive Care in Cancer","volume":"33 4","pages":"291"},"PeriodicalIF":2.8,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143650419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The use of artificial nutrition at the end-of-life: a cross-sectional survey exploring the beliefs and decision-making among physicians and nurses.","authors":"Christophe Pala, Claudia Gamondi, Steffen Eychmuller, Francois Herrmann, Sophie Pautex","doi":"10.1007/s00520-025-09310-2","DOIUrl":"10.1007/s00520-025-09310-2","url":null,"abstract":"<p><strong>Background: </strong>The use of artificial nutrition in the last month of life raises many concerns for patients, relatives, and healthcare professionals.</p><p><strong>Aim: </strong>To describe physicians and nurses' beliefs, knowledge, and decision-making related to introducing and withdrawing artificial nutrition at the end-of-life. Physicians and nurses' factors affecting these decisions were examined.</p><p><strong>Design: </strong>A cross-sectional study was conducted between May and July 2022. A questionnaire was sent by email to physicians and nurses.</p><p><strong>Setting and participants: </strong>Physicians and nurses working in internal medicine, oncology, and palliative medicine divisions in three Swiss University Hospitals.</p><p><strong>Results: </strong>Two hundred and thirty physicians and nurses completed the survey (21% response rate). Most responders, aged 25-45, were women with < 10 years of experience, 61% lacked palliative care experience. End-of-life decision-making on artificial nutrition was reported as common by 89%. Whereas physicians and nurses played an important role in the decision, fulfilling patients' wishes (84% of cases) tended to dominate over professionals' intentions (physicians 52%, nurses 67%) as motivators at final decision. The main reasons for introducing artificial nutrition included improving nutritional status (54%), reducing broncho-aspiration (67%), and preventing pressure ulcers (53%). Having palliative care experience was the only variable modifying the beliefs of these motivations.</p><p><strong>Conclusion: </strong>Whereas decisions on artificial nutrition at the end of life are common they may be mostly guided by physicians and nurses' beliefs, and patients' requests more than by robust evidence. Fostering palliative care education is pivotal. Our results emphasize the need to improve physicians and nurses' awareness of the complex interplay between values and evidence when decisions concerning artificial nutrition are taken.</p>","PeriodicalId":22046,"journal":{"name":"Supportive Care in Cancer","volume":"33 4","pages":"287"},"PeriodicalIF":2.8,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11914226/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143650671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship between physical activity and quality of life among patients with respiratory and digestive system cancer during and outside the COVID-19 pandemic.","authors":"Hui-Mei Chen, Jiu-Yun Tian, Wei-Ling Gao, Zih-Yun Deng, Pei-Shan Ho, Yi-Yun Lin","doi":"10.1007/s00520-025-09334-8","DOIUrl":"https://doi.org/10.1007/s00520-025-09334-8","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate the relationship between physical activity (PA) and quality of life (QOL) among patients with respiratory and digestive system cancers during and outside of the COVID-19 pandemic.</p><p><strong>Methods: </strong>A longitudinal, repeated-measures observational design was employed, and data were collected from outpatient clinics and wards during both the pandemic and a nonpandemic period at baseline (T1) and 3 months postrecruitment (T2). The Bouchard 3-Day Physical Activity Record questionnaire and the European Organisation for Research and Treatment of Cancer (EORTC) Quality of Life Core Questionnaire (physical function subscale) were used to measure PA and QOL, respectively.</p><p><strong>Results: </strong>A total of 313 patients with various cancers (including lung, esophageal, gastric, pancreatic, and colon cancers) participated in this study. Light-intensity PA was significantly and positively correlated with the physical function dimension of QOL during both the pandemic (r = 0.31, p < 0.001) and nonpandemic (r = 0.15, p = 0.010) periods. Furthermore, light-intensity PA was a significant predictor of the physical function dimension of QOL during both the pandemic and nonpandemic periods (B = 0.04, p < 0.001; B = 0.02, p = 0.007, respectively).</p><p><strong>Conclusions: </strong>Light-intensity PA is a critical predictor of the physical function domain of QOL in patients with respiratory and digestive system cancers during both pandemic and nonpandemic periods. Promoting engagement in tolerable PA may improve the health of these patients.</p>","PeriodicalId":22046,"journal":{"name":"Supportive Care in Cancer","volume":"33 4","pages":"288"},"PeriodicalIF":2.8,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143650225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recovering or working: women's experiences of working while coping with cancer: a qualitative study.","authors":"Avital Gershfeld-Litvin, Olga Vishnia, Tsipi Hanalis-Miller","doi":"10.1007/s00520-025-09349-1","DOIUrl":"10.1007/s00520-025-09349-1","url":null,"abstract":"<p><strong>Purpose: </strong>The aim of this study was to explore women's experiences of working and returning to work while coping with cancer.</p><p><strong>Methods: </strong>Participants were ten Israeli women with cancer who had an active career at the time of diagnosis. Semi-structured interviews were conducted and thematically analyzed.</p><p><strong>Results: </strong>Four themes were generated. The first was \"the meaning of work prior to the diagnosis\": participants shared their perspective on the significance of work in their life prior to being diagnosed with cancer-work was construed as either time-consuming, a source for socializing, or a source for meaning and self-worth. The second was \"the diagnosis of cancer and work\": participants held the belief that either the cancer was caused by work or that the cancer halted their careers, in some cases both applied. The third was \"the combination of work and cancer treatments\": participants described severe physical, cognitive, and emotional challenges they faced, and how these affected their ability to balance work with receiving treatments. The fourth was \"returning to work after cancer\": participants found themselves having to balance preventative and rehabilitative care with career demands, employer expectations, and general work-life balance adjustments.</p><p><strong>Conclusion: </strong>Findings suggest that healthcare professionals should assess individual perspectives and capabilities prior to returning to work and elucidate opportunities and challenges that cancer survivors may meet. Findings also reaffirm the need for formal workplace education and policies to combat discrimination and tailored return to work opportunities to survivors.</p><p><strong>Implications for cancer survivors: </strong>Women's experiences of working while coping with cancer were thematically analyzed. These women face many challenges in the context of returning to work. Findings suggest that returning to work could be facilitated by healthcare professionals and employers through communication and tailored workplace policies.</p>","PeriodicalId":22046,"journal":{"name":"Supportive Care in Cancer","volume":"33 4","pages":"289"},"PeriodicalIF":2.8,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11913926/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143650186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Receiving immunotherapy for the treatment of advanced renal cell carcinoma is associated with higher burden of illness, coagulopathy, cardiac arrhythmia, and disparities.","authors":"Susan Eichhorn, Roberto Pili, Joel B Epstein, Richa Rajesh, Poolakkad S Satheeshkumar","doi":"10.1007/s00520-025-09353-5","DOIUrl":"https://doi.org/10.1007/s00520-025-09353-5","url":null,"abstract":"<p><strong>Background: </strong>The adverse outcomes and costs of immunotherapy (IT) have yet to be fully explored. Our study aims to assess the association between the use of IT in patients with metastatic renal cell carcinoma (mRCC) and the burden of illness (BOI), including coagulopathy, arrhythmia, and disparities.</p><p><strong>Methods: </strong>The study used US national data to investigate the association between the use of IT in the mRCC and the BOI. The BOI was measured by total charges and length of stay (LOS). Additionally, we examined coagulopathy, arrhythmia, and disparities in these outcomes. This investigation was conducted using generalized linear models (glm).</p><p><strong>Results: </strong>Of 28,535 patients who had mRCC, 230 had previously received IT. In the adjusted glm, after accounting for other variables, \"IT\" was found to be associated with higher total charges- (coeff = 7.67; 95% CI 4.86 - 12.09). There was no association with IT and LOS. Coagulopathy (aOR = 5.61; 95% CI 2.40 - 13.14) and arrhythmia (aOR = 4.34; 95% CI 2.20 - 8.55) were associated with IT treatment. Moreover, compared to males, females had a lower cardiac arrhythmia risk (aOR 0.83, 95% CI 0.72-0.98). Non-whites, compared to Whites, had a higher total charge (1.21, 95% CI 1.13-1.29), higher coagulopathies (aOR 1.25; 95% CI 1.01-1.54), but lower cardiac arrhythmia risk (aOR 0.57; 95% CI 0.47-0.69).</p><p><strong>Conclusion: </strong>Although IT has become increasingly important in treating mRCC, this is the first time real-world data on the costs, negative consequences, and disparities of IT are examined. The results may have important implications for creating innovative, supportive care models for this population.</p>","PeriodicalId":22046,"journal":{"name":"Supportive Care in Cancer","volume":"33 4","pages":"285"},"PeriodicalIF":2.8,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143634498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}