Supportive Care in Cancer最新文献

{"title":"Comment on \"Patient-reported pain severity is associated with shorter survival in older adults with newly diagnosed cancer\".","authors":"Prajnasini Satapathy, Rachana Mehta, Ranjana Sah","doi":"10.1007/s00520-025-09974-w","DOIUrl":"10.1007/s00520-025-09974-w","url":null,"abstract":"","PeriodicalId":22046,"journal":{"name":"Supportive Care in Cancer","volume":"33 10","pages":"903"},"PeriodicalIF":3.0,"publicationDate":"2025-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145226061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Construction of a postoperative home-based pulmonary rehabilitation program protocol for lung cancer patients delivered using the internet: A Delphi-based study.","authors":"Haoyu Zou, Jiani Qu, Yanqing Li, Feilin Wang, Pan Chen, Liuyi Zhang, Honghui Zhang","doi":"10.1007/s00520-025-09916-6","DOIUrl":"10.1007/s00520-025-09916-6","url":null,"abstract":"<p><strong>Objective: </strong>To construct a protocol to guide standardized home-based pulmonary rehabilitation for postoperative lung cancer patients based on the Internet + .</p><p><strong>Methods: </strong>A postoperative home-based pulmonary rehabilitation protocol via the Internet (PHPRPI) for patients with lung cancer was developed through a literature review. The protocol was modified based on the opinions and suggestions of experts in two rounds of expert consultation, utilizing the Delphi method. A three-level, hierarchical structure was employed in the Delphi method, with primary indicators representing broad, overarching concepts, secondary indicators providing more specific details within those concepts, and tertiary indicators offering the most granular and actionable measures. The following coefficients were calculated to assess the robustness of the Delphi method: the positive coefficient was calculated as the percentage of experts completing the questionnaire, with a recommended level of ≥ 70%. The expert authority coefficient (Cr) was calculated as the arithmetic mean of familiarity criteria (Ca) and the degree of familiarity (Cs), with a recommended level of ≥ 0.70. The coefficient of variation (CV) and Kendall's harmony coefficient (ω) were used to indicate the degree of variation and coordination, which range from 0 to 1, with higher values indicating more consistent expert opinions.</p><p><strong>Results: </strong>Eighteen experts completed two rounds of consultation, with the Cr being 0.91, the ω being 0.159 (P < 0.01), and the CV ranging from 0.0477 to 0.1352, indicating good reliability of the Delphi method. The final protocol includes four primary indicators (including composition of the staff, establishment of patient health records, off-line intervention, and online intervention), 14 secondary indicators (e.g., personnel professional, specialized assessment, training frequency, and breathing training methods), and 44 tertiary indicators (e.g., vital sign assessment, content of health education, resistance training, and flexibility training).</p><p><strong>Conclusion: </strong>The PHPRPI provides preliminary evidence to guide postoperative home-based rehabilitation management for lung cancer patients, aiming to improve their health outcomes and well-being. Future randomized controlled trials (RCTs) are needed to further validate the safety and effectiveness of this model and assess whether it is acceptable to patients and healthcare providers.</p>","PeriodicalId":22046,"journal":{"name":"Supportive Care in Cancer","volume":"33 10","pages":"905"},"PeriodicalIF":3.0,"publicationDate":"2025-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12496294/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145226043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identifying opioid misuse in cancer pain: validation of the prescription opioid misuse index in a multicenter study.","authors":"Virginie Guastella, Mélanie Bianchi, Eliane Hanniet, Bruno Pereira, Nicolas Authier","doi":"10.1007/s00520-025-09942-4","DOIUrl":"10.1007/s00520-025-09942-4","url":null,"abstract":"<p><strong>Objectives: </strong>The prevalence of analgesic opioid (AO) misuse among patients with cancer-related chronic pain remains poorly understood, and no screening tool has been validated for this population. The Prescription Opioid Misuse Index (POMI), an eight-item self-administered questionnaire, was developed for chronic non-cancer pain. This study aimed to evaluate the psychometric properties of the POMI in a population of patients with chronic cancer-related pain.</p><p><strong>Methods: </strong>This prospective observational psychometric study was conducted in two oncology day hospitals at the Clermont-Ferrand University Hospital. Eligible patients had active cancer, chronic pain lasting ≥ 3 months and were receiving daily opioid therapy. The POMI questionnaire was completed at inclusion (TEST) and 2 weeks later (RETEST). Psychometric properties were assessed following standard guidelines, including internal consistency, test-retest reliability and external validity using DSM-5 criteria for opioid use disorder as the reference standard.</p><p><strong>Results: </strong>A total of 138 patients were included (58% men), with a mean age of 64 ± 10 years. Internal consistency of the POMI was low (Kuder-Richardson coefficient: 0.22). Test-retest reliability, assessed in 68 patients, showed moderate agreement (Lin's concordance: 0.43 [0.24-0.63]). Correlation between POMI scores and DSM-5 criteria was modest (Spearman's ρ = 0.25). According to the POMI, 11.6% of patients demonstrated opioid misuse versus 17.4% with DSM-5-defined use disorder.</p><p><strong>Conclusions: </strong>The POMI lacks sufficient psychometric validity for use in oncology populations. Future tools should be specifically designed to address the clinical complexity and unique context of chronic cancer-related pain and opioid use.</p>","PeriodicalId":22046,"journal":{"name":"Supportive Care in Cancer","volume":"33 10","pages":"902"},"PeriodicalIF":3.0,"publicationDate":"2025-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12494673/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145226049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Decision-making when a child with haematological malignancy relapses following haematopoietic stem cell transplantation: A meta-ethnographic review.","authors":"Deborah Tomlinson, Simran Kaur, Jane Lowry, Sonia Lucchetta, Jessie Cunningham, Joerg Krueger","doi":"10.1007/s00520-025-09914-8","DOIUrl":"10.1007/s00520-025-09914-8","url":null,"abstract":"<p><strong>Purpose: </strong>Lived experience and decision-making processes for families, following relapse after haematopoietic stem cell transplant (HSCT) in children, are under-reported. This meta-ethnographic review aims to synthesize qualitative studies that investigate how families conceptualize and cope with difficult decision-making situations, which can include treatment following relapse or refractory disease, decision for HSCT, and clinical trial enrolment.</p><p><strong>Methods: </strong>Qualitative synthesis was conducted using meta-ethnography. The search was executed across seven bibliographic databases. Initial screening did not identify any eligible studies addressing decision-making following relapse after HSCT. Qualitative studies that reported on parental, child, and healthcare professionals' decision-making in difficult situations were included. Potentially eligible studies, which included families of a child < 18 years of age, were retrieved in full for further review. Data abstraction and analysis involved considering and identifying constructs from included studies. Data were organized to show descriptions and patterns of content, which was then summarized to show key patterns in content and concepts.</p><p><strong>Results: </strong>Of 4355 unique references identified, 23 were included from 67 retrieved in full. Synthesis led to the emergence of two concepts: (1) precision in adapting to family needs and (2) communication and information to help prevent decision regret.</p><p><strong>Conclusion: </strong>As treatment for relapse following HSCT becomes more complex, families will have greater choices with unclear outcomes for their child. Future research should focus on investigating their lived experience. Greater understanding of the experience when a child with haematological malignancy relapses following HSCT will assist in improving care for these families, both in the short-term and in the psychological well-being of those involved in making these difficult decisions.</p>","PeriodicalId":22046,"journal":{"name":"Supportive Care in Cancer","volume":"33 10","pages":"904"},"PeriodicalIF":3.0,"publicationDate":"2025-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145225972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Health utility book: A systematic review and meta-analysis of health utilities in gastric cancer.","authors":"Shant Torkom Yeretzian, Brittany Humphries, Meixuan Li, Chiranjeev Sanyal, Gaurav Talwar, Michael Xu, Peijing Yan, Frances Simbulan, Zhiyuan Chen, Pei Wang, Ting Zhou, Veena Manja, Xuejing Jin, Yuan Sun, Preston Tse, Michael J Zoratti, Shitong Xie, Feng Xie","doi":"10.1007/s00520-025-09993-7","DOIUrl":"10.1007/s00520-025-09993-7","url":null,"abstract":"<p><strong>Purpose: </strong>The treatment landscape in gastric cancer has changed drastically over the last 15 years with surgical advancements and the introduction of new therapeutic agents and combinations. Despite the potential for improved survival, these new interventions can impact health-related quality of life (HRQoL). Our objective was to identify and synthesize health utility data for gastric cancer patients as part of the Health Utility Book (HUB) project.</p><p><strong>Methods: </strong>We searched MEDLINE, EMBASE, EconLit, and CINAHL from inception to March 2023 for original studies that reported health utility data for gastric cancer. Records were screened independently and in duplicate by two reviewers. Data on study design, patient characteristics, and health utilities were extracted using a standardized form. A random effects meta-analysis was conducted to synthesize health utilities by cancer stage. Heterogeneity was evaluated using the I² statistic.</p><p><strong>Results: </strong>600 health utilities from 3,405 respondents were identified across 19 studies. All studies were published between 2018 and 2022 and most were conducted in Asia (n = 12, 63.2%). The EQ-5D was the most common method of preference elicitation (n = 17, 89.5%), and health utilities ranged from 0.298 (SD 0.088) to 0.920 (SD 0.130). Mean health utilities from random effects models were 0.82 (95% Confidence Interval [CI] 0.76-0.88), 0.76 (95% CI 0.68-0.85), and 0.67 (95% CI 0.46-0.87) for early stage, advanced stage, and metastatic gastric cancer, respectively.</p><p><strong>Conclusion: </strong>This systematic review provides a reference set of health utilities for gastric cancer, which can help understand HRQoL and facilitate the retrieval and selection of health utilities for economic evaluations.</p>","PeriodicalId":22046,"journal":{"name":"Supportive Care in Cancer","volume":"33 10","pages":"907"},"PeriodicalIF":3.0,"publicationDate":"2025-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145226038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An environmental scan and qualitative inquiry of cancer patient navigation services in North Carolina.","authors":"Leila M Fathi-Boldt, Karl Umble, Austin R Waters, Erin E Kent","doi":"10.1007/s00520-025-09870-3","DOIUrl":"10.1007/s00520-025-09870-3","url":null,"abstract":"<p><strong>Background and objectives: </strong>Patient navigation services reduce barriers to accessing cancer care and can improve health outcomes. Thousands of individuals are diagnosed with cancer and seek treatment in North Carolina (NC) each year. We completed a digital environmental scan and qualitative inquiry of cancer patient navigation services throughout the state to better inform patients and health system administrators about the current and future state of cancer patient navigation programs throughout NC.</p><p><strong>Methods: </strong>An environmental scan of publicly available information on hospital websites about navigation services and key informant interviews with navigation staff at each site were conducted from September 2022 to March 2023.</p><p><strong>Results: </strong>Seven cancer hospitals representing seven independent health systems participated. Each cancer hospital had a page dedicated to cancer navigation, but many sites were incomplete regarding the specificity of patient services. Interviews revealed that navigation services are available to cancer patients across diagnoses, although only a subset of patients receive services depending on need and available resources. Interview participants reported that services include care coordination, patient advocacy, emotional support, and addressing of non-medical barriers to health care access (transportation, finances, childcare, etc.). Each navigation service had a unique configuration and referral pattern.</p><p><strong>Conclusions: </strong>NC cancer hospitals are working to address barriers to care common to patients, with some programs offering more robust services compared to others. Health systems would benefit from updating their publicly facing cancer hospital websites at regular intervals to communicate available services to patients and caregivers, including direct patient navigation contact methods.</p>","PeriodicalId":22046,"journal":{"name":"Supportive Care in Cancer","volume":"33 10","pages":"900"},"PeriodicalIF":3.0,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145213848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Symptom clusters in colorectal cancer: a systematic review of assessment tools, statistical methods, and symptom patterns.","authors":"Wenqian Qi, Wei Guo, Jing Yuan, Ruzhen Zhou, Xue Liu, Jiajia Deng, Jing Cui","doi":"10.1007/s00520-025-09920-w","DOIUrl":"10.1007/s00520-025-09920-w","url":null,"abstract":"<p><strong>Purpose: </strong>To summarize the assessment methodology, statistical analysis, and composition of symptom clusters in patients with colorectal cancer.</p><p><strong>Methods: </strong>Published studies on symptom clusters in patients with colorectal cancer were identified through searches. A search was conducted for studies published between January 2001 and July 2024 using databases such as PubMed, Cochrane Library, Web of Science, CINAHL, Embase, and China National Knowledge Infrastructure. The quality of the studies was assessed using a set of criteria from the JBI Reviewers' Manual. A narrative synthesis of the findings was conducted.</p><p><strong>Results: </strong>Eleven studies from seven countries were included, representing 4001 participants. The assessment tools and statistical analyses varied among the studies. Overall, the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ) and principal component analysis were the most frequently used tools. The most reported symptom clusters were (1) fatigue/lack of energy, anxiety/worry/nervousness, and depression/sadness/upset; (2) nausea, vomiting, and lack of appetite; (3) pain and sleep disorder/insomnia; and (4) pain/abdominal pain and feeling bloated.</p><p><strong>Conclusions: </strong>In addition to the more general fatigue-anxiety-depression symptom cluster, special attention should be given to colorectal cancer-specific clusters, such as nausea-vomiting-appetite loss and abdominal pain-feeling bloated. The identification of symptom clusters requires careful interpretation based on the assessment tools and statistical methods used. Future research is suggested to prioritize the use of disease-specific measures and advanced analytical approaches, such as network analysis, to enhance the understanding and clinical management of these clusters.</p>","PeriodicalId":22046,"journal":{"name":"Supportive Care in Cancer","volume":"33 10","pages":"899"},"PeriodicalIF":3.0,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145213827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Changes in nutritional status in hepatocellular carcinoma patients treated with sorafenib.","authors":"Radosław Osmański, Marcin Mardas, Piotr Radomyski, Maria Litwiniuk, Marta Stelmach-Mardas","doi":"10.1007/s00520-025-09975-9","DOIUrl":"10.1007/s00520-025-09975-9","url":null,"abstract":"<p><strong>Purpose: </strong>Musculoskeletal imbalance is often overlooked in clinical management, although in hepatocellular carcinoma (HCC) it has been associated with adverse outcomes. We aimed to assess the nutritional status using Computed Tomography (CT) scans, in HCC patients and its association with progression-free survival (PFS) and overall survival (OS).</p><p><strong>Methods: </strong>A total of 122 patients were qualified for systemic therapy due to HCC, 73 for sorafenib treatment. The nutritional status was assessed using CT, Body Mass Index (BMI), the prognostic nutritional index (PNI) and on the Nutritional Risk Score (NRS) 2002 scale. The ECOG Performance Status Scale was used to assess the patients' level of functioning. The classification of the liver failure was described with the Child-Pugh scale. The Barcelona Clinic Liver Cancer classification system was used for patients management. Survival analyses were performed.</p><p><strong>Results: </strong>NRS and BMI were not significantly related to PFS and OS. Nutritional status changed significantly during 6 months of sorafenib treatment; however, the sarcopenia was not detected. The low PNI deteriorates significantly both PFS and OS. Significant differences between median time of survival in patients that lost more than 10% in visceral or subcutaneous fat or muscle mass in comparison to those with stable parameters were noticed: Subcutaneous Adipose Tissue Index (SATI): PFS-9.5 vs 16.4 months, OS-15.95 vs 24.5 months; Visceral Adipose Tissue Index (VATI): 11 vs. 15.75 months; SMI: PFS-11.5 vs 15.75 months, OS-22 vs 24.1 months; PMI: PFS-9.2 vs 16.15 months, OS-14.5vs 24.5 months.</p><p><strong>Conclusion: </strong>The loss in fat and muscle mass in patients undergoing sorafenib therapy for HCC was associated with poorer PFS and OS.</p>","PeriodicalId":22046,"journal":{"name":"Supportive Care in Cancer","volume":"33 10","pages":"901"},"PeriodicalIF":3.0,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12494665/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145225994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on \"Standardized gynecologic consultation and bone surveillance in patients with breast cancer receiving hormone therapy\"2.","authors":"Rachana Mehta, Ranjana Sah","doi":"10.1007/s00520-025-09980-y","DOIUrl":"10.1007/s00520-025-09980-y","url":null,"abstract":"","PeriodicalId":22046,"journal":{"name":"Supportive Care in Cancer","volume":"33 10","pages":"898"},"PeriodicalIF":3.0,"publicationDate":"2025-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145207581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Posttraumatic growth in parents long after their child's death from cancer-a cross-sectional survey in Switzerland.","authors":"Eddy Carolina Pedraza, Peter Francis Raguindin, Anna Katharina Vokinger, Eva De Clercq, Manya Jerina Hendriks, Eva Maria Tinner, André Oscar von Bueren, Katrin Scheinemann, Eva Bergsträsser, Gisela Michel","doi":"10.1007/s00520-025-09892-x","DOIUrl":"10.1007/s00520-025-09892-x","url":null,"abstract":"<p><strong>Background: </strong>The death of a child is one of the most devastating experiences for parents, yet some may experience positive changes known as posttraumatic growth (PTG). We aimed to describe PTG in bereaved parents whose child died of cancer, compare it to PTG in parents of childhood cancer survivors, and identify sociodemographic and child-related characteristics associated with PTG in bereaved parents.</p><p><strong>Methods: </strong>This multicenter cross-sectional study included parents who lost a child to cancer (diagnosed ≤ 18 years and > 1 year after death). Data from the Swiss Childhood Cancer Survivor Study-Parents were used for comparison. We used the Posttraumatic Growth Inventory (PTGI) assessing five domains (appreciation of life, new possibilities, personal strength, relating to others, and spiritual change) on a 6-point scale.</p><p><strong>Results: </strong>We included 103 bereaved parents (mean age = 53.7 years, SD = 8.3; 66.7% female) of 81 deceased children (mean age at death = 9.5 years, SD = 5.9; mean time after death = 11.3 years, range 2-24 years). The PTG sum score was 63.2 (SD = 23.3, range = 4-105), which was higher than in parents of survivors (mean = 51.4; SD = 21.0, p = 0.002). Bereaved parents reported higher mean domain scores in appreciation of life (3.53, SD = 1.17 vs. 3.01, SD = 1.17, p = 0.003), personal strength (3.42, SD = 1.25 vs. 2.75, SD = 1.17, p = 0.001), relating to others (3.09, SD = 1.09 vs. 2.61, SD = 1.04 p 0.004), and new possibilities (2.69, SD = 1.26 vs. 1.97, SD = 1.17, p < 0.001). Parents within 10 years of their child's death and those practicing religion reported higher PTG.</p><p><strong>Conclusion: </strong>Our findings reveal that cancer-bereaved parents may experience PTG after their child's death, embracing unique positive changes according to their circumstances and influencing factors.</p>","PeriodicalId":22046,"journal":{"name":"Supportive Care in Cancer","volume":"33 10","pages":"896"},"PeriodicalIF":3.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12488827/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145201437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}