Supportive Care in Cancer最新文献

{"title":"Possible prevention of paclitaxel-induced peripheral neuropathy by concomitant use of α1-receptor antagonist based on a retrospective study.","authors":"Kohei Mori, Takehiro Kawashiri, Keisuke Mine, Haruna Ishida, Yusuke Mori, Mami Ueda, Yusuke Koura, Shunsuke Fujita, Akito Tsuruta, Nobuaki Egashira, Ichiro Ieiri, Satoru Koyanagi, Takao Shimazoe, Daisuke Kobayashi","doi":"10.1007/s00520-025-09368-y","DOIUrl":"https://doi.org/10.1007/s00520-025-09368-y","url":null,"abstract":"<p><strong>Purpose: </strong>Paclitaxel and albumin-bound paclitaxel are important anticancer drugs for the treatment of non-small cell lung, pancreatic, gastric, and gynecological cancers; however, they cause peripheral neuropathy as an adverse reaction. Therefore, prophylaxis and treatment for peripheral neuropathy are needed, since there are no sufficient evidence-based strategies to prevent it. Our previous animal research and adverse effect database analysis studies have identified the potential of α1 antagonists to attenuate paclitaxel-induced peripheral neuropathy (PIPN). The purpose of the present study was to investigate the prophylactic potential of α1 antagonists for PIPN in patients with cancer.</p><p><strong>Methods: </strong>Data were collected from the medical records of 673 male patients aged 18 years and older who started treatment with paclitaxel- or albumin-bound paclitaxel-containing regimens at Kyushu University Hospital between January 1, 2013, and December 31, 2019. The two primary outcome measures were PIPN occurrence and paclitaxel discontinuation due to PIPN. Kaplan-Meier curves were generated for cumulative doses and evaluated using the log-rank test.</p><p><strong>Results: </strong>The percentage of patients in whom PIPN occurred (any grade) during the entire study period was 37.4% and 20.0% in without and with α1-receptor antagonist groups, respectively (P = 0.0101, χ² test). The incidence of PIPN (any grade) was significantly lower in the α1 antagonists combination group (N = 55) than in the no α1-receptor antagonists group (N = 618) (P = 0.0425, log-rank test). However, there were no significant differences between the two groups in the discontinuation of paclitaxel due to PIPN (P = 0.9654).</p><p><strong>Conclusions: </strong>The present retrospective cohort study may suggest that concomitant use of α1-receptor antagonists may moderate the development of PIPN.</p>","PeriodicalId":22046,"journal":{"name":"Supportive Care in Cancer","volume":"33 4","pages":"316"},"PeriodicalIF":2.8,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143693427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cancer-related cognitive impairment in patients with hematologic malignancies after CAR T cell therapy: a systematic review and meta-analysis of prevalence.","authors":"Mu-Hsing Ho, Denise Shuk Ting Cheung, Tongyao Wang, Lizhen Wang, Justin Wei Ho Wong, Chia-Chin Lin","doi":"10.1007/s00520-025-09356-2","DOIUrl":"10.1007/s00520-025-09356-2","url":null,"abstract":"<p><strong>Purpose: </strong>Cancer-related cognitive impairment is one of the symptoms of neurotoxicity among patients receiving chimeric antigen receptor (CAR) T cell therapy. Evidence of the overall estimated prevalence of cancer-related cognitive impairment following CAR T-cell therapy among patients with hematologic malignancies at short-term and long-term follow-ups is lacking. This review aimed to summarize the cognitive functioning status and estimate the prevalence of cancer-related cognitive impairment at follow-up within 1 month, 1 to 12 months, and > 12 months after CAR T cell therapy.</p><p><strong>Methods: </strong>PubMed, Cochrane Library, EMBASE, CINAHL Plus, Web of Science, and PsycINFO via ProQuest from inception through August 2024. Studies that reported on cognitive impairment among patients receiving CAR T cell therapy with valid measures were included. Data on cognitive impairment prevalence were pooled using a random-effects model.</p><p><strong>Results: </strong>In total, 16 studies involving 1407 patients were included. The pooled cancer-related cognitive impairment prevalence rates assessed using neuropsychological tests at the follow-up timepoints (< 1 month, 1-12 months, and > 12 months) were 24% [95% prediction interval (PI) 16-33%], 33% (95%, PI 9-64%), and 35% (95%, PI 23-48%), respectively. The prevalence estimates assessed using other measures were ranging from 4 to 38% across different timepoints. The leave-one-out meta-analyses quantified the impact of these potential outliers on the estimation of the overall prevalence.</p><p><strong>Conclusions: </strong>The findings stress the importance of developing targeted interventions to prevent or manage cognitive impairment in cancer patients during both short-term and long-term follow-up periods. This review also highlights the need for further research in this area to improve our understanding of the disease mechanisms and implement preventive strategies for managing cancer-related cognitive impairment.</p>","PeriodicalId":22046,"journal":{"name":"Supportive Care in Cancer","volume":"33 4","pages":"312"},"PeriodicalIF":2.8,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11929693/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143693426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A retrospective cohort study of the oral healthcare needs of cancer patients.","authors":"Sophie Beaumont, Aimee Liu, Katrusha Hull","doi":"10.1007/s00520-025-09314-y","DOIUrl":"10.1007/s00520-025-09314-y","url":null,"abstract":"<p><strong>Purpose: </strong>Oral health and its impact on general well-being is acutely evident with a cancer diagnosis. Most cancer treatments will affect the oral environment, with poor oral health having the potential to negatively impact cancer treatment outcomes.</p><p><strong>Methods: </strong>This retrospective study included 1500 patients referred for dental examination prior to cancer therapy at the Peter MacCallum Cancer Centre, Australia, between January 2017 and August 2019. Demographic characteristics, cancer diagnosis, and baseline oral health information were recorded.</p><p><strong>Results: </strong>Patients were referred from the head and neck tumour stream (56%), haematology (27.7%), breast and genitourinary (6.1%), and others (9.7%). Of the patients who required dental treatment 49% required a dental extraction prior to their cancer treatment to optimise oral health. Head and neck cancer patients presented with poorer oral hygiene and required more dental extractions than other patient groups (χ² = 17.59, p = 0.00003).</p><p><strong>Conclusions: </strong>Baseline oral health for cancer patients was below expected compared with the Australian average. Dental treatment was necessary for more than half of patients to reduce infection risk and improve function and quality of life during and following cancer treatment, highlighting the essential role of oral health clinicians in the multidisciplinary team.</p>","PeriodicalId":22046,"journal":{"name":"Supportive Care in Cancer","volume":"33 4","pages":"314"},"PeriodicalIF":2.8,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11929681/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143693422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Return to work or leaving work? Differences of return to work between breast cancer patients and the general population and determinants of return to work.","authors":"Siegfried Geyer, Stefanie Sperlich, Eranda Sahiti, Dorothee Noeres","doi":"10.1007/s00520-025-09364-2","DOIUrl":"10.1007/s00520-025-09364-2","url":null,"abstract":"<p><strong>Purpose: </strong>It was examined whether employment among breast cancer survivors was lower than in the general population 4 to 6 years after surgery. We also examined whether disease severity, post-surgical treatment, social, and workplace characteristics have effects on employment as primary outcome, and whether the distance from surgery to observation may determine employment.</p><p><strong>Methods: </strong>We performed a multicentric observational study with four survey waves. Data were collected based on mailed surveys and patient records. Patients were up to 63 years old at entry with TNM-tumour stages T0 to TIV. Comparisons with the general population were performed by drawing controls from the German Socio-Economic Panel.</p><p><strong>Results: </strong>N = 372 breast cancer survivors participated in all surveys (= 82.2% of the initial sample). Their rate of occupationally active women was lower than in the general population (OR_patients = 0.59; 95% CI = 0.42-0.84; p < 0.01). Among patients, tumour stage had no effects on employment 12 months after surgery; 4-6 years later, this was the case only among patients with the most unfavourable tumour stage (OR = 0.16; p = 0.01; 95% CI = 0.04-0.58). Antihormone therapy was unrelated with employment (OR = 0.80; p = 0.27; 95% CI = 0.54-1.19); inpatient rehabilitation was negatively associated at 12 months after surgery (OR = 0.47; p = 0.02; 95% CI = 0.25-0.89) and unrelated at the last survey wave (OR = 0.95; p = 0.86; 95% CI = 0.55-1.64). Compared with the lowest level of occupational autonomy, it was unrelated with employment 12 months after surgery (OR = 0.79; p = 0.75; 95% CI = 0.18-4.41), but for the highest level of autonomy, it had significant effects 4 to 6 years later (OR = 4.56; p = 0.04; 95% CI = 1.10-18.81). Effort-reward imbalance as a continuously scaled indicator of pre-surgery occupational distress was significantly associated with return to work 12 months after surgery (OR = 0.13; p < 0.01; 95% CI = 0.06-0.31), but it had no effect at the last survey wave (OR = 0.64; p = 0.31; 95% CI = 0.28-1.50). One year after surgery, education at higher levels had no significant effects on return to work (OR = 1.30; p = 0.57; 95% CI = 0.56-3.00 for the highest level compared with the lowest one), only at the last measurement marked differences by education emerged (OR = 2.23; p = 0.03; 95% CI = 1.08-4.63).</p><p><strong>Conclusion: </strong>Temporal distance between surgery and survey wave determines whether potentially influencing factors have effects. Disease severity and post-surgical treatment were unrelated to employment. Whether work-related and socio-demographic factors are determining employment depends on the date of measurement.</p>","PeriodicalId":22046,"journal":{"name":"Supportive Care in Cancer","volume":"33 4","pages":"313"},"PeriodicalIF":2.8,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11929724/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143693343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association between allostatic load and lymphedema in breast cancer survivors.","authors":"Barnabas Obeng-Gyasi, Yevgeniya Gokun, Mohamed I Elsaid, J C Chen, Barbara L Andersen, William E Carson, Sachin Jhawar, Jesus D Anampa, Dionisia Quiroga, Roman Skoracki, Samilia Obeng-Gyasi","doi":"10.1007/s00520-025-09362-4","DOIUrl":"10.1007/s00520-025-09362-4","url":null,"abstract":"<p><strong>Purpose: </strong>Allostatic load, a measure of physiological dysregulation secondary to chronic exposure to socioenvironmental stressors, is associated with 30-day postoperative complications and mortality in patients with breast cancer. This study aimed to examine the association between allostatic load (AL) at diagnosis and development of breast cancer-related lymphedema (BCRL).</p><p><strong>Methods: </strong>Patients aged 18 years or older who received surgical treatment for stage I-III breast cancer between 2012 and 2020 were identified from The Ohio State University Cancer Registry. AL was calculated using biomarkers from the cardiovascular, metabolic, renal, and immunologic systems. A high AL was defined as AL > median. Logistic regression analyses examined the association between AL and BRCL, adjusting for sociodemographic, clinical, and treatment factors.</p><p><strong>Results: </strong>Among 3,609 patients, 18.86% (n = 681) developed lymphedema. A higher proportion of patients with lymphedema were Black (11.89% vs. 7.38%, p < 0.0001), Medicaid insured (12.19% vs. 6.97%, p < 0.0001), had stage 3 disease (7.05% vs. 1.57%, p < 0.0001), and had a high AL (53.63% vs. 46.90%, p = 0.0018). In adjusted analysis, high AL was associated with higher odds of developing lymphedema than low AL (OR 1.281 95% CI 1.06-1.55). Moreover, a 1-unit increase in AL was associated with 10% higher odds of lymphedema (OR 1.10, 95% CI 1.04-1.16). There was no statistically significant association between AL and severity of lymphedema (OR 1.02, 95% CI 0.82-1.23).</p><p><strong>Conclusion: </strong>In this retrospective cohort of breast cancer survivors, high AL at diagnosis was associated with higher odds of developing lymphedema. Future research should elucidate the pathways by which AL influences lymphedema.</p>","PeriodicalId":22046,"journal":{"name":"Supportive Care in Cancer","volume":"33 4","pages":"311"},"PeriodicalIF":2.8,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11928421/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143674459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"What services are available for culturally and linguistically diverse (CALD) patients in the cancer survivorship setting? An Australian study.","authors":"Lawrence Kasherman, Isaac Yeboah Addo, Sim Yee Cindy Tan, Ashanya Malalasekera, Joanne Shaw, Janette Vardy","doi":"10.1007/s00520-025-09348-2","DOIUrl":"10.1007/s00520-025-09348-2","url":null,"abstract":"<p><strong>Purpose: </strong>People of Culturally and Linguistically Diverse (CALD) backgrounds face disparities in cancer care. This study aimed to explore CALD-specific Cancer Survivorship (CS) resources and supports in Australian oncology centres.</p><p><strong>Methods: </strong>This was an interview-based, qualitative study. Oncology professionals were interviewed using a questionnaire exploring demographics, available resources and referral patterns, and factors influencing CALD CS care. Purposive sampling was used to ensure representation across states and remoteness areas. Contextual survey data were analysed with descriptive statistics, and interviews were recorded and transcribed for thematic analysis.</p><p><strong>Results: </strong>Twenty-two interviews from 15 institutions across 6 Australian states were conducted from May to August 2023. Six (40%) centres reported seeing > 25% CALD patients. Six (40%) centres reported having dedicated CS services dichotomised into clinic-based or needs-based services. Ten (67%) centres reported having CALD-specific resources/supports for oncology patients, and three (20%) had CS-specific services. Four themes were identified: patient-clinician interface; in-language resources with a focus on cultural relevance; structural and logistical considerations, particularly interpreter services, workflow management and models of care; and education and collaboration between healthcare professionals and survivors, carers and community leaders.</p><p><strong>Conclusions: </strong>Cancer survivors from CALD backgrounds face unique challenges in receiving optimal care, with limited availability of CALD-specific resources in Australian cancer centres. Future work should utilise a tailored and collaborative approach to optimise cultural relevance and service engagement.</p>","PeriodicalId":22046,"journal":{"name":"Supportive Care in Cancer","volume":"33 4","pages":"309"},"PeriodicalIF":2.8,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11928404/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143674551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Behind closed doors: a qualitative study exploring the content of fertility discussions between oncologists and their adolescent and young adult cancer patients from the perspective of oncologists at an NCI-designated comprehensive cancer center.","authors":"Julia Stal, Charleen I Roche, Serena Y Yi, David R Freyer, Rachel C Ceasar, Sue E Kim, Joel E Milam, Kimberly A Miller","doi":"10.1007/s00520-025-09269-0","DOIUrl":"10.1007/s00520-025-09269-0","url":null,"abstract":"<p><strong>Purpose: </strong>To qualitatively explore the content of fertility discussions between oncologists and their adolescent and young adult (AYA; 15-39 years) cancer patients from the perspective of oncologists at an NCI-designated comprehensive cancer center.</p><p><strong>Methods: </strong>We recruited oncologists of various specialties employed at an NCI-designated comprehensive cancer center in California who treat AYAs at risk for infertility. We collected demographics and fertility-related information (if they discuss fertility with AYA patients and level of confidence doing so) via REDCap prior to conducting a semi-structured interview via HIPAA-compliant Zoom. Audio files were transcribed verbatim and reviewed for themes using an inductive codebook thematic analysis approach.</p><p><strong>Results: </strong>Oncologists (n = 12) were female (66.7%), of White or Asian race (41.7% each), and were on average in practice for 14.3 years (SD = 6.7). All endorsed discussing fertility with AYAs and were on average somewhat/fairly confident doing so. The detail with which oncologists reported discussing fertility with AYAs varied substantially and only some reported discussing costs associated with fertility preservation. Oncologists also reported assorted information they always mention, mention on a case-by-case basis, avoid, or feel is not necessary when discussing fertility.</p><p><strong>Conclusion: </strong>This study provides a detailed description of information delivered by oncologists during fertility discussions to their AYA patients, revealing unstandardized oncofertility counseling. Fertility discussions were described to vary widely in depth and content, suggesting adherence to clinical practice guidelines limited. Interventions to increase provision of guideline-concordant counseling are needed to provide actionable pathways by which AYAs can proactively mitigate adverse reproductive health outcomes.</p>","PeriodicalId":22046,"journal":{"name":"Supportive Care in Cancer","volume":"33 4","pages":"308"},"PeriodicalIF":2.8,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11925993/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143671005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Self- and informant-reported cognitive concerns associated with primary brain tumour: systematic review.","authors":"Shelley Mekler, Sian Virtue-Griffiths, Kerryn Pike","doi":"10.1007/s00520-025-09345-5","DOIUrl":"10.1007/s00520-025-09345-5","url":null,"abstract":"<p><strong>Purpose: </strong>People with primary brain tumour (PBT) experience objective cognitive impairment, but subjective cognitive concerns have received less attention. This review sought to determine the type of self- and informant-reported cognitive concerns following PBT and to ascertain if they vary according to patient, tumour and/or treatment characteristics. Further objectives were to determine whether subjective reports aligned with objective findings or informant reports.</p><p><strong>Methods: </strong>Literature searches were conducted using PsycINFO and Medline, limited to English-language and full-text format. Studies focusing on non-PBTs, objective cognition without subjective reports, or paediatric PBT were excluded.</p><p><strong>Results: </strong>Eleven studies were included, representing the cognitive concerns of 957 PBT participants, with varying tumour types/treatment, and ranging from pre-surgery to an average of 5 years post-diagnosis. Subjective concerns regarding global perceived cognitive impairment, language, memory, executive function, and attention were common, but change in processing speed, visual function, and reading/spelling were also reported. Few studies investigated factors impacting subjective cognition, but there was some suggestion that left-lateralised and larger tumours resulted in more subjective concerns. The alignment between objective and subjective cognition varied, ranging from strong to weak, whereas the overlap between patient and informant reports was robust.</p><p><strong>Conclusions: </strong>Identifying the alignment between patient and informant reports is of significant benefit when considering treatment interventions and outcomes for people with PBT, particularly in instances where they may not be able to report their cognitive concerns. Overall, the importance of the patient perspective was highlighted, which can often be replaced by objective measures in clinical research.</p>","PeriodicalId":22046,"journal":{"name":"Supportive Care in Cancer","volume":"33 4","pages":"310"},"PeriodicalIF":2.8,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11928433/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143674455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to: A systematic review of salivary gland hypofunction and/or xerostomia induced by non‑surgical cancer therapies: prevention strategies.","authors":"Valeria Mercadante, Derek K Smith, Ragda Abdalla-Aslan, Ana Andabak-Rogulj, Michael T Brennan, Graziella Chagas Jaguar, Haley Clark, Eduardo Rodrigues Fregnani, Luiz Alcino Gueiros, Allan Hovan, Seema Kurup, Alexa M G A Laheij, Charlotte Duch Lynggaard, Joel J Napeñas, Douglas E Peterson, Sharon Elad, Stephanie Van Leeuwen, Arjan Vissink, Jonn Wu, Deborah P Saunders, Siri Beier Jensen","doi":"10.1007/s00520-025-09327-7","DOIUrl":"10.1007/s00520-025-09327-7","url":null,"abstract":"","PeriodicalId":22046,"journal":{"name":"Supportive Care in Cancer","volume":"33 4","pages":"305"},"PeriodicalIF":2.8,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11926020/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143671007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"More than \"hematology\": a qualitative study on the experience of hematologists treating people with blood cancer in Greece.","authors":"Nikolaos Vrontaras, George Koulierakis, Dimitrios Kyrou, Anargyros Kapetanakis, Aliki Xochelli, Paolo Ghia, Kostas Stamatopoulos, Christina Karamanidou","doi":"10.1007/s00520-025-09320-0","DOIUrl":"10.1007/s00520-025-09320-0","url":null,"abstract":"<p><strong>Purpose: </strong>The present study aims to investigate the experiences of hematologists providing care to patients with hematological malignancies, whose care is pertinent to oncology.</p><p><strong>Methods: </strong>Semi-structured interviews with 30 hematologists across Greece were conducted. The interviews took place over the course of 6 months at 2020. Reflexive thematic analysis was employed for data analysis.</p><p><strong>Results: </strong>Three key themes (personal impact, organizational framework, and relating to patients) and eight subthemes were generated: (1) Hematologists were greatly affected on a personal level, as they had poor life-work balance and impacted social relationships. They experienced a great emotional toll, sometimes questioning the meaning of their work. They frequently struggled with loss, by witnessing people's passing. Nevertheless, they reported coping better over time. (2) On an organizational level, hematologists supported each other emotionally, but only rarely had formal support in managerial or administrative recourses. They were also hindered by structural restraints, both in terms of limited psychosocial training and supportive services. (3) Hematologists' relationship with their patients increased their job satisfaction. However, they strived to keep boundaries while balancing how close they got to their patients.</p><p><strong>Conclusion: </strong>High job demands, organizational shortcomings, and emotional challenges negatively impact their well-being and pose the risk of developing compassion fatigue or burnout. At the same time, individual resources, teamwork, and strong personal relationships emerged as crucial coping elements, providing meaning and resilience. Psychosocial training and institutional support should be offered both personally and professionally to enhance hematologists' well-being and reduce potential turnover.</p>","PeriodicalId":22046,"journal":{"name":"Supportive Care in Cancer","volume":"33 4","pages":"307"},"PeriodicalIF":2.8,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11925966/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143671012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}