Supportive Care in Cancer最新文献

{"title":"Experience implementing the serious illness care program through virtual training of multidisciplinary teams at a regional cancer centre.","authors":"Russell Leong, Sandra Andreychuk, Cheryl Shoemaker, Georgia Georgiou, Helena Adjekum, Ruth Locis, Adrienne Sultana, Suganya Vadivelu, Oren Levine","doi":"10.1007/s00520-025-09525-3","DOIUrl":"https://doi.org/10.1007/s00520-025-09525-3","url":null,"abstract":"<p><strong>Purpose: </strong>The Serious Illness Care Program (SICP) was launched at the Juravinski Cancer Centre (JCC) to promote early, high-quality goals of care conversations with patients experiencing advanced cancer. Training was provided to multidisciplinary disease site teams (DSTs). The objective of this study is to validate the virtual SICP training format and assess the clinician and patient experience after 6 months of implementation.</p><p><strong>Methods: </strong>Clinicians completed SICP training through a virtual workshop on Zoom and responded to surveys describing their experience before and after the training. Clinicians then completed a validated survey 6 months later, describing their experience of implementing serious illness conversations (SIC) into practice. Consenting patients were contacted within 2 weeks of a SIC encounter and responded to validated questions about their experience.</p><p><strong>Results: </strong>Training was provided to 52 healthcare providers in the breast, lung and brain malignancy DSTs. Overall, the virtual training format was well received. Training could be improved by allowing more time to practice skills and including more video examples. By 6 months, 39% of clinicians reported conducting SIC. Most users reported that SIC helps them understand patient goals. Among non-users, insufficient time was the most cited barrier. Nurses in a non-primary care model reported difficulty engaging in SIC. Most patients felt that SIC was a worthwhile experience.</p><p><strong>Conclusion: </strong>Our study demonstrates the feasibility of the virtual SICP implementation process. Additionally, SICP was successfully delivered across multidisciplinary DSTs. Training will continue rolling out incrementally for all DSTs at the JCC, exploring the incorporation of self-learning modules.</p>","PeriodicalId":22046,"journal":{"name":"Supportive Care in Cancer","volume":"33 6","pages":"468"},"PeriodicalIF":2.8,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144035488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stakeholder perspectives on the role of caregivers in cancer clinical trial decision-making: results of a qualitative study.","authors":"Eric C Blackstone, Susan R Mazanec, Barbara J Daly, Jennifer A Dorth, Alberto J Montero, Mark P Aulisio, Patricia T Brandt, Helen Foley, Sana Loue","doi":"10.1007/s00520-025-09505-7","DOIUrl":"https://doi.org/10.1007/s00520-025-09505-7","url":null,"abstract":"<p><strong>Purpose: </strong>Family caregivers assist cancer patients in making medical decisions, yet their roles in clinical trial decisions remain understudied. This study aimed to determine how caregivers participate in clinical trial decisions from the perspectives of both caregivers and research staff.</p><p><strong>Methods: </strong>Family caregivers of patients offered participation in a clinical trial and clinical trial staff were recruited for focus groups and semi-structured interviews. Participants were asked about caregiver roles in clinical trial decisions and practices of staff to include caregivers during the informed consent process.</p><p><strong>Results: </strong>Qualitative analysis revealed these caregiver themes: promoting patient autonomy, influential factors, and burdens of participation. Themes specific to clinical trial staff included the following: caregiver role in decision, approaches to caregiver inclusion, caregiver utility to trial staff, and navigating challenging situations. Caregivers reported helping patients make better decisions without influencing them, while clinical trial staff viewed caregivers as highly influential. The hope for therapeutic benefit was a strong motivator for caregivers to support participation in the trial despite burdens they encountered. Clinical trial staff found caregivers to be useful in facilitating communication and adherence to the study protocol.</p><p><strong>Conclusion: </strong>Caregivers should be included early in clinical trial discussions due to their key role in decision-making and facilitating adherence. Clinical trial staff would benefit from training on communication with caregivers and identifying support to alleviate caregiver burden. The cancer research community should explore ways to decrease caregiver burden when possible or provide compensation when caregivers sacrifice time and effort to facilitate clinical trial participation.</p>","PeriodicalId":22046,"journal":{"name":"Supportive Care in Cancer","volume":"33 6","pages":"464"},"PeriodicalIF":2.8,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144054652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors influencing the decision to discontinue treatment due to chemotherapy-induced peripheral neuropathy among patients with metastatic breast cancer: a best-worst scaling.","authors":"Rotana M Radwan, John F P Bridges, Daniel L Hertz, Maryam B Lustberg, Hetal Vachhani, Erin Hickey Zacholski, Vanessa B Sheppard, Teresa M Salgado","doi":"10.1007/s00520-025-09508-4","DOIUrl":"https://doi.org/10.1007/s00520-025-09508-4","url":null,"abstract":"<p><strong>Purpose: </strong>To measure the importance of factors that influence the decision to discontinue treatment due to chemotherapy-induced peripheral neuropathy (CIPN) among patients with metastatic breast cancer (mBC).</p><p><strong>Methods: </strong>An online survey incorporating a best-worst scaling (BWS) was conducted among women in the USA with mBC and experiencing CIPN. In the BWS, women chose the most and least important factors influencing their decision to discontinue treatment due to CIPN. Seven factors were included: relieving current neuropathy symptoms, reducing risk of long-term neuropathy, having another cancer treatment option, understanding the risk of treatment discontinuation, and receiving support for treatment discontinuation from the oncologist, loved ones, or patients with similar experiences. To measure the importance of each factor, a conditional logit model estimated coefficients, which were subsequently rescaled to importance scores that summed to 100. The dependent variable was the choice of a factor as most or least important across seven choice tasks.</p><p><strong>Results: </strong>The sample included 189 women with a mean age of 52.5 (SD = 12.65) years, 52.9% were White, 33.9% were Black, and 64.6% held a bachelor's degree or higher. When faced with the decision to discontinue treatment due to CIPN, the most important factors were having another cancer treatment option (score 23.5), followed by understanding the risk of treatment discontinuation (score 19.2), and reducing risk of long-term neuropathy (score 19.1). The least important factors in the decision to discontinue treatment due to CIPN were: support from loved ones (score 5.2) and support from other patients (score 3.3).</p><p><strong>Conclusion: </strong>When faced with the decision to discontinue treatment due to CIPN, women with mBC attributed more importance to survival and reducing the risk of long-term CIPN. Knowledge of what matters most to patients may assist with shared decision-making to optimize therapeutic outcomes in patients receiving neurotoxic chemotherapy.</p>","PeriodicalId":22046,"journal":{"name":"Supportive Care in Cancer","volume":"33 6","pages":"467"},"PeriodicalIF":2.8,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12065726/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144011202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A systematic review on the effects of logotherapy and meaning-centered therapy on psychological and existential symptoms in women with breast and gynecological cancer.","authors":"Andrea Aiello-Puchol, Joaquín García-Alandete","doi":"10.1007/s00520-025-09519-1","DOIUrl":"https://doi.org/10.1007/s00520-025-09519-1","url":null,"abstract":"<p><strong>Purpose: </strong>Women diagnosed with breast cancer (BC) and gynecological cancer (GC) face psychological and existential challenges common to all cancers, such as anxiety and depression, along with specific issues related to body image and sexuality. Logotherapy and meaning-centered therapy (MCT) have shown positive effects on the psychological well-being of cancer patients.</p><p><strong>Methods: </strong>A systematic review was conducted following PRISMA guidelines to assess the impact of logotherapy and meaning-centered therapy (MCT) on women diagnosed with BC and GC from January 2014 to December 2024. Empirical research articles published in English were included, while literature reviews, meta-analyses, doctoral theses, preprints, books, and studies involving other cancer types or metastatic/comorbid conditions were excluded. The search was conducted across Web of Science, Scopus, and PubMed databases using terms like uterine cancer, ovarian cancer, breast cancer, mastectomy, logotherapy, and MCT. The Boolean operators AND and OR were used in the Title and Abstract search fields across all three databases, as well as in the Topic search field for the WoS database.</p><p><strong>Results: </strong>Out of the 36 articles initially obtained, 29 remained after eliminating duplicates and, finally, six papers were selected. The included studies examined various psychological and existential issues in patients with breast and gynecological cancer, including anxiety, distress, depression, hopelessness, death anxiety, post-traumatic stress, perception of physical symptoms, quality of life, post-traumatic growth, spiritual well-being, and meaning in life.</p><p><strong>Conclusion: </strong>Findings suggest that logotherapy decreases depressive symptoms, anxiety, and post-traumatic stress, whereas improves meaning in life, quality of life, physical symptom perception, and post-traumatic growth in women with BC and GC. Implementing logotherapy in cancer care units through a multidisciplinary approach could be valuable, considering biopsychosocial factors, and incorporating aspects of self-image and sexuality in treatment would also be beneficial.</p>","PeriodicalId":22046,"journal":{"name":"Supportive Care in Cancer","volume":"33 6","pages":"465"},"PeriodicalIF":2.8,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12065743/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144042709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early and simultaneous palliative care in cancer patients: an overview.","authors":"Mara Vicenzini, Sara Di Lorenzo, Margherita Venturini","doi":"10.1007/s00520-025-09501-x","DOIUrl":"10.1007/s00520-025-09501-x","url":null,"abstract":"<p><strong>Purpose: </strong>The timing of access to palliative care is still a debated topic. We aim to investigate recent evidence on early and simultaneous palliative care to better understand what the most appropriate timing for integration and its impact on the quality of life of cancer patients and their carers might be.</p><p><strong>Methods: </strong>This is an overview of systematic reviews published between November 2020 and February 2024. Three search strings were launched on the PubMed, CINAHL, Cochrane Library and Scopus databases. Results were screened according to the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) statement.</p><p><strong>Results: </strong>A total of 17/1052 articles were selected. The following categories emerged and were described: need to define a timing for integration; definition of specific criteria for referral; access to palliative care; benefits of early and simultaneous palliative care; needs of patients and carers and their preferences. No specific timing for referral to palliative care emerged: one article suggested within 8 weeks of diagnosis, while another identified multiple time points. The term \"supportive care\" appears to facilitate early referral to palliative care services.</p><p><strong>Conclusion: </strong>There is ample evidence that early and simultaneous access to palliative care ensures a better care pathway. Although it is not possible to standardise referral times, communication between professionals, patients and carers, shared and advance care planning are key elements in the identification of palliative care needs and their early integration. Much research is still needed to ensure equitable and appropriate access to palliative care.</p>","PeriodicalId":22046,"journal":{"name":"Supportive Care in Cancer","volume":"33 6","pages":"462"},"PeriodicalIF":2.8,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144032382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fertility counseling in early-onset colorectal cancer and the impact of patient characteristics.","authors":"Chengwei Peng, Dalia Littman, Lena Masri, Scott Sherman, Danil V Makarov, Daniel J Becker","doi":"10.1007/s00520-025-09517-3","DOIUrl":"https://doi.org/10.1007/s00520-025-09517-3","url":null,"abstract":"<p><strong>Purpose: </strong>This study evaluated how frequently patients with early onset colorectal cancer received fertility counseling and whether patient characteristics affected the likelihood of receiving such counseling.</p><p><strong>Methods: </strong>We conducted a single-center retrospective review of all new patients seen by medical oncology for colorectal cancer who were age 55 years or younger for men and 50 years or younger for women. Associations between patient demographics and clinical characteristics with receipt of fertility counseling were explored using univariate analyses and multivariable logistical regression analyses.</p><p><strong>Results: </strong>A total of 194 patients were included, of whom 15.5% received fertility counseling. Using multivariate analysis, we found that age < 40 (OR 15.587, p < 0.0001, 95% CI 4.841-50.191) and female sex (OR 3.979, p = 0.0292, 95% CI 1.150-13.770) were correlated with increased likelihood of fertility counseling. Patients living in areas of higher household income were more likely to receive fertility counseling, with a statistically significant difference between the 3rd and 1st quartiles of income (p = 0.0369, 95% CI 1.161-115.940).</p><p><strong>Conclusion: </strong>A majority of patients with EOCRC did not receive fertility counseling despite the known toxicities of CRC treatment modalities on fertility. Older age, male sex, and residence in areas of lower income were associated with decreased likelihood of receiving fertility counseling.</p>","PeriodicalId":22046,"journal":{"name":"Supportive Care in Cancer","volume":"33 6","pages":"466"},"PeriodicalIF":2.8,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144049246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the relationship between postoperative psychological resilience and symptom burden in esophageal cancer patients.","authors":"Mengmeng Yuan, Anqi Miao, Ranran Qin, Yanni Qin, Shuwen Li","doi":"10.1007/s00520-025-09509-3","DOIUrl":"10.1007/s00520-025-09509-3","url":null,"abstract":"<p><strong>Purpose: </strong>Psychological resilience (PR) is an important internal resource for alleviating symptom burden in esophageal cancer surgery patients. However, the relationship between PR and symptom burden has not been explored to date. The primary purpose of this study is to determine the relationship between these two variables.</p><p><strong>Methods: </strong>This multi-center cross-sectional study analyzed data from 486 esophageal cancer surgery patients (2022-2024), assessing symptom burden and PR using the Convalescence Symptom Assessment Scale for Esophagectomy Patients and the Connor-Davidson Resilience Scale. Symptom burden was visualized with radar charts, and network analysis identified the relationship between PR and symptom burden.</p><p><strong>Results: </strong>Esophageal cancer patients experienced a significant symptom burden in the early postoperative period. Network analysis revealed that helplessness (Bridge Strength = 0.23), close and secure relationships (Bridge Strength = 0.21), disturbed sleep (Bridge Strength = 0.11), and pride in your achievements (Bridge Strength = 0.08) were bridge nodes connecting the combination network. Among these, helplessness was identified as a critical factor in initiating and sustaining the relationship between PR and symptom burden.</p><p><strong>Conclusions: </strong>PR plays a crucial role in alleviating symptom burden. This study identifies the bridge nodes in the combination network of PR and symptom burden in esophageal cancer patients. Implementing interventions targeting these factors may enhance the precision and effectiveness of symptom management.</p>","PeriodicalId":22046,"journal":{"name":"Supportive Care in Cancer","volume":"33 6","pages":"463"},"PeriodicalIF":2.8,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144015182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Illness perception, cognitive emotion regulation strategies and psychological distress in breast cancer patients and spouses: an actor-partner interdependence mediation model.","authors":"Xiaoting Zheng, Baoxin Huang, Carmen Wing Han Chan, Jian Zhou, Feng Liu, Ka Ming Chow, Wenli Xiao","doi":"10.1007/s00520-025-09513-7","DOIUrl":"https://doi.org/10.1007/s00520-025-09513-7","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to examine the relationships between illness perception, cognitive emotion regulation strategies (CERS), and psychological distress, and the mediating role of CERS in breast cancer patients and their spouses.</p><p><strong>Methods: </strong>A cross-sectional study recruited 305 pairs of breast cancer patients and their spouses to complete the sociodemographic and clinical characteristics questionnaire, the Cognitive Emotion Regulation Questionnaire-short, and the Hospital Anxiety and Depression Scale. Descriptive statistics, difference analysis, Pearson's correlation coefficient, and the actor-partner interdependence mediation model were conducted.</p><p><strong>Results: </strong>There was a significant correlation between illness perception, CERS, and psychological distress in breast cancer patients and their spouses (r = -0.416 ~ 0.522, P < 0.05). Both patients' and spouses' illness perception could directly produce significant actor effects on psychological distress, or indirectly through the mediator of maladaptive or adaptive CERS of their own. Only spouses' illness perception could produce significant partner effect on patients' psychological distress. Moreover, only spouses' illness perception could produce significant effects on patients' psychological distress through patients' or spouses' maladaptive CERS.</p><p><strong>Conclusion: </strong>Our findings offered a new perspective on how illness perception, CERS, and psychological distress were interconnected at both personal and dyadic levels. The findings underscored the significance of intervening with breast cancer patients and spouses as a closely knit dyad to promote the adoption of adaptive CERS while reduce the use of maladaptive CERS, which may be associated with lower levels of psychological distress.</p>","PeriodicalId":22046,"journal":{"name":"Supportive Care in Cancer","volume":"33 6","pages":"461"},"PeriodicalIF":2.8,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144048194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Coping strategies for fear of cancer recurrence among breast cancer survivors: a systematic review and thematic synthesis of qualitative studies.","authors":"Abbas Mardani, Maryam Maleki, Nasrin Hanifi, Hannele Turunen, Mojtaba Vaismoradi","doi":"10.1007/s00520-025-09503-9","DOIUrl":"10.1007/s00520-025-09503-9","url":null,"abstract":"<p><strong>Aim: </strong>Breast cancer (BC) is the most common cancer in women, and many survivors experience fear of cancer recurrence (FCR). This study aimed to explore and integrate qualitative evidence on the coping strategies BC survivors use to manage FCR.</p><p><strong>Methods: </strong>A systematic review and thematic synthesis of qualitative studies was conducted. Six databases including PubMed, Scopus, CINAHL, Web of Science, PsycInfo, and Embase were searched without any time restrictions using predefined keywords. Inductive thematic synthesis was conducted to identify key coping strategies used by BC survivors.</p><p><strong>Results: </strong>Sixteen studies were included, identifying four themes of coping strategies: \"seeking support,\" \"transforming health behaviors and lifestyle\" \"avoidance and emotional detachment\", and \"building resilience and emotional strength\". Each encompassed sub-themes.</p><p><strong>Conclusion: </strong>This review identified various coping strategies used by BC survivors to manage the FCR. They highlight the complexity and diversity of responses to FCR, rather than assessing their effectiveness. The findings underscore the importance of understanding coping mechanisms within the context of survivorship care, which can inform future research on their short- and long-term impacts. Healthcare providers should consider individualized approaches that acknowledge the nuanced nature of coping strategies used by BC survivors.</p>","PeriodicalId":22046,"journal":{"name":"Supportive Care in Cancer","volume":"33 6","pages":"459"},"PeriodicalIF":2.8,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143986554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Moving from theory to practice: implementing a prehabilitation program before gastrointestinal cancer surgery (PREHAB-GI).","authors":"Kristy-Lee Raso, Michael Suen, Sam Egger, Jane Turner, Sonia Khatri, Yanlan Lin, Carolyn Wildbore, Caoimhe Scales, Shannon Gerber, Kin Yin Carol Chan, Guillermo Becerril-Martinez, Philip Le Page, Sim Yee Cindy Tan, Janette Vardy","doi":"10.1007/s00520-025-09496-5","DOIUrl":"https://doi.org/10.1007/s00520-025-09496-5","url":null,"abstract":"<p><strong>Purpose: </strong>Surgery remains the primary treatment for early-stage colorectal and upper gastrointestinal (UGI) cancers. However, it can lead to postoperative complications and reduced functionality. Prehabilitation aims to improve functional reserves before surgery. We aimed to evaluate the implementation of a multimodal prehabilitation program in \"real-world\" patients undergoing gastrointestinal cancer surgery.</p><p><strong>Methods: </strong>An implementation study evaluating prehabilitation in patients undergoing gastrointestinal (colorectal or UGI) cancer surgery at Concord Hospital. The prehabilitation program included supervised exercise, nutrition and nursing support delivered face-to-face or by telehealth (COVID-19 adaptations).</p><p><strong>Assessments: </strong>baseline, pre-surgery and 30 days after surgery.</p><p><strong>Primary outcome: </strong>implementation using the RE-AIM (Reach/Effectiveness/Adoption/Implementation/Maintenance) framework.</p><p><strong>Secondary outcomes: </strong>functional, nutritional and surgical outcomes, with comparisons to historical controls.</p><p><strong>Results: </strong>Between January 2020 and December 2021, 181 patients were screened; 91 (50%) were eligible. Reach: 77/91 recruited (63 colorectal, 14 UGI). Median age, 70 years (IQR, 59-79); 60% were males. Median intervention duration, 16 days (IQR, 12.25-19.75).</p><p><strong>Effectiveness: </strong>quality of life, anxiety and functional capacity improved from baseline to pre-surgery (6-min walk test (+16.1 m, p=0.038) and 2-min step test (+10.0 steps, p<0.001)). Compared to historical controls, hospital length of stay was reduced by 2.1 days (p=0.010), with no differences in complications. Adoption: 91% of referrals came directly from surgeons.</p><p><strong>Implementation: </strong>94% completed the intervention, with high adherence and satisfaction levels. Maintenance: after study completion, the program was incorporated into standard care with some modifications.</p><p><strong>Conclusions: </strong>Prehabilitation can be implemented in a real-world setting, with a trend towards improving functional and surgical outcomes, but dedicated resources are necessary to implement and maintain the program.</p>","PeriodicalId":22046,"journal":{"name":"Supportive Care in Cancer","volume":"33 6","pages":"458"},"PeriodicalIF":2.8,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12062105/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144018316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}