{"title":"癌症患者化疗所致口腔黏膜炎的危险因素：一项系统综述和荟萃分析。","authors":"Hui Zheng, Mingqi Zhang, Tingting Xiao, Yicen Zheng, Lianfang Cheng, Meiling Huang, Man Zhang, Lichun Xu","doi":"10.1007/s00520-025-09629-w","DOIUrl":null,"url":null,"abstract":"<p><strong>Purpose: </strong>This systematic review aims to identify the factors influencing chemotherapy-induced oral mucositis in cancer patients.</p><p><strong>Methods: </strong>A comprehensive literature search was conducted across PubMed, Web of Science, Embase, The Cochrane Library, VIP, Wanfang, CNKI, CBM, and CINAHL from the establishment of the databases to August 2024. Meta-analysis was performed using RevMan5.4 software, with odds ratios (OR) and 95% confidence intervals (CI) used to assess the risk factors. Methodological quality was assessed using the Newcastle-Ottawa Scale (NOS) and the evaluation criteria recommended by the Agency for Healthcare Research and Quality (AHRQ). The quality of evidence was graded using the GRADEpro GDT.</p><p><strong>Results: </strong>The analysis included 10 studies with a total of 2365 patients. Six studies were of high quality, and four studies were of moderate quality. The results indicated that the following factors were associated with an increased risk of chemotherapy-induced oral mucositis (CIOM) in cancer patients: a history of oral disease, combination chemotherapy, smoking history, oral hygiene, and chemotherapy regimens containing 5-FU/methotrexate.</p><p><strong>Conclusion: </strong>This meta-analysis identified several potential independent risk factors for CIOM in cancer patients. Early screening and timely intervention for patients with these risk factors are crucial for reducing the likelihood of CIOM and improving overall prognosis.</p>","PeriodicalId":22046,"journal":{"name":"Supportive Care in Cancer","volume":"33 7","pages":"613"},"PeriodicalIF":2.8000,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Risk factors for chemotherapy-induced oral mucositis in cancer patients: a systematic review and meta-analysis.\",\"authors\":\"Hui Zheng, Mingqi Zhang, Tingting Xiao, Yicen Zheng, Lianfang Cheng, Meiling Huang, Man Zhang, Lichun Xu\",\"doi\":\"10.1007/s00520-025-09629-w\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Purpose: </strong>This systematic review aims to identify the factors influencing chemotherapy-induced oral mucositis in cancer patients.</p><p><strong>Methods: </strong>A comprehensive literature search was conducted across PubMed, Web of Science, Embase, The Cochrane Library, VIP, Wanfang, CNKI, CBM, and CINAHL from the establishment of the databases to August 2024. Meta-analysis was performed using RevMan5.4 software, with odds ratios (OR) and 95% confidence intervals (CI) used to assess the risk factors. Methodological quality was assessed using the Newcastle-Ottawa Scale (NOS) and the evaluation criteria recommended by the Agency for Healthcare Research and Quality (AHRQ). The quality of evidence was graded using the GRADEpro GDT.</p><p><strong>Results: </strong>The analysis included 10 studies with a total of 2365 patients. Six studies were of high quality, and four studies were of moderate quality. The results indicated that the following factors were associated with an increased risk of chemotherapy-induced oral mucositis (CIOM) in cancer patients: a history of oral disease, combination chemotherapy, smoking history, oral hygiene, and chemotherapy regimens containing 5-FU/methotrexate.</p><p><strong>Conclusion: </strong>This meta-analysis identified several potential independent risk factors for CIOM in cancer patients. Early screening and timely intervention for patients with these risk factors are crucial for reducing the likelihood of CIOM and improving overall prognosis.</p>\",\"PeriodicalId\":22046,\"journal\":{\"name\":\"Supportive Care in Cancer\",\"volume\":\"33 7\",\"pages\":\"613\"},\"PeriodicalIF\":2.8000,\"publicationDate\":\"2025-06-23\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Supportive Care in Cancer\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1007/s00520-025-09629-w\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"HEALTH CARE SCIENCES & SERVICES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Supportive Care in Cancer","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s00520-025-09629-w","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"HEALTH CARE SCIENCES & SERVICES","Score":null,"Total":0}
引用次数: 0
摘要
目的：本系统综述旨在探讨癌症患者化疗所致口腔黏膜炎的影响因素。方法：综合检索PubMed、Web of Science、Embase、The Cochrane Library、VIP、万方、CNKI、CBM、CINAHL等数据库自建库至2024年8月的文献。采用RevMan5.4软件进行meta分析，采用比值比（OR）和95%置信区间（CI）评估危险因素。采用纽卡斯尔-渥太华量表（NOS）和卫生保健研究与质量机构（AHRQ）推荐的评价标准对方法学质量进行评估。使用GRADEpro GDT对证据质量进行分级。结果：纳入10项研究，共2365例患者。6项研究为高质量，4项研究为中等质量。结果提示，以下因素与癌症患者发生化疗性口腔黏膜炎（CIOM）的风险增加相关：口腔疾病史、联合化疗、吸烟史、口腔卫生、含5-FU/甲氨蝶呤的化疗方案。结论：本荟萃分析确定了癌症患者CIOM的几个潜在独立危险因素。对具有这些危险因素的患者进行早期筛查和及时干预对于降低CIOM的可能性和改善整体预后至关重要。
Risk factors for chemotherapy-induced oral mucositis in cancer patients: a systematic review and meta-analysis.
Purpose: This systematic review aims to identify the factors influencing chemotherapy-induced oral mucositis in cancer patients.
Methods: A comprehensive literature search was conducted across PubMed, Web of Science, Embase, The Cochrane Library, VIP, Wanfang, CNKI, CBM, and CINAHL from the establishment of the databases to August 2024. Meta-analysis was performed using RevMan5.4 software, with odds ratios (OR) and 95% confidence intervals (CI) used to assess the risk factors. Methodological quality was assessed using the Newcastle-Ottawa Scale (NOS) and the evaluation criteria recommended by the Agency for Healthcare Research and Quality (AHRQ). The quality of evidence was graded using the GRADEpro GDT.
Results: The analysis included 10 studies with a total of 2365 patients. Six studies were of high quality, and four studies were of moderate quality. The results indicated that the following factors were associated with an increased risk of chemotherapy-induced oral mucositis (CIOM) in cancer patients: a history of oral disease, combination chemotherapy, smoking history, oral hygiene, and chemotherapy regimens containing 5-FU/methotrexate.
Conclusion: This meta-analysis identified several potential independent risk factors for CIOM in cancer patients. Early screening and timely intervention for patients with these risk factors are crucial for reducing the likelihood of CIOM and improving overall prognosis.
期刊介绍：
Supportive Care in Cancer provides members of the Multinational Association of Supportive Care in Cancer (MASCC) and all other interested individuals, groups and institutions with the most recent scientific and social information on all aspects of supportive care in cancer patients. It covers primarily medical, technical and surgical topics concerning supportive therapy and care which may supplement or substitute basic cancer treatment at all stages of the disease.
Nursing, rehabilitative, psychosocial and spiritual issues of support are also included.
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