Effects of relaxation training combined with music-based intervention on anxiety and depression in patients undergoing hematopoietic stem cell transplantation: a quasi-experimental study.
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Abstract
Objective: To evaluate the effects of relaxation training combined with music-based intervention on anxiety and depression in patients undergoing hematopoietic stem cell transplantation (HSCT).
Method: This quasi-experimental study included patients with hematologic tumors who underwent HSCT at the Affiliated Hospital of Xuzhou Medical University between July 2022 and November 2023. Participants were divided into a control group and an experimental group. The control group received conventional care, while the experimental group received relaxation training combined with music-based intervention in addition to conventional care. A total of 62 patients completed the study. Anxiety and depression levels were assessed using the 7-item Generalized Anxiety Disorder Scale (GAD-7) and the 9-item Patient Health Questionnaire (PHQ-9), respectively. Biological indicators related to anxiety and depression, including blood pressure, heart rate, and cytokines such as interleukin-1β (IL-1β), interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α), were also evaluated.
Results: Compared with the control group, the experimental group demonstrated significant reductions in depression, blood pressure, and cytokine levels of IL-1β, IL-6, and TNF-α. However, no statistically significant changes were observed in anxiety or heart rate.
Conclusion: Relaxation training combined with music-based intervention effectively alleviated depression in HSCT patients and influenced biological markers associated with anxiety and depression, including blood pressure and cytokines IL-1β, IL-6, and TNF-α. Nonetheless, no significant changes was noted in anxiety or heart rate.
Trial and protocol registration: This study has been registered on the International Traditional Medicine Clinical Trial Registry, with the clinical trial registration number ITMCTR2025000412.
期刊介绍：
Supportive Care in Cancer provides members of the Multinational Association of Supportive Care in Cancer (MASCC) and all other interested individuals, groups and institutions with the most recent scientific and social information on all aspects of supportive care in cancer patients. It covers primarily medical, technical and surgical topics concerning supportive therapy and care which may supplement or substitute basic cancer treatment at all stages of the disease.
Nursing, rehabilitative, psychosocial and spiritual issues of support are also included.
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