Small Structures最新文献_第8页

Multifunctional Nanodrug-Mediated Immunotherapy in Microsatellite Stable Colorectal Cancer via Promoting m6A Modification and M1-Like Tumor-Associated Macrophages Polarization 多功能纳米药物通过促进 m6A 修饰和 M1 型肿瘤相关巨噬细胞极化对微卫星稳定型结直肠癌进行免疫治疗

Small Structures Pub Date : 2024-06-19 DOI: 10.1002/sstr.202400100

Caiying Li, Gengjia Chen, Tan Li, Peiyi Xie, Decai Ma, Long Yang, Zecong Xiao, Xintao Shuai, Xiaochun Meng

{"title":"Multifunctional Nanodrug-Mediated Immunotherapy in Microsatellite Stable Colorectal Cancer via Promoting m6A Modification and M1-Like Tumor-Associated Macrophages Polarization","authors":"Caiying Li, Gengjia Chen, Tan Li, Peiyi Xie, Decai Ma, Long Yang, Zecong Xiao, Xintao Shuai, Xiaochun Meng","doi":"10.1002/sstr.202400100","DOIUrl":"https://doi.org/10.1002/sstr.202400100","url":null,"abstract":"Immunotherapy has made great progress in various solid tumors. However, the “cold” tumor immune microenvironment of microsatellite stable subtype colorectal cancer (MSS-CRC) hinders the effectiveness of immunotherapy. Therefore, reshaping the immunosuppressive microenvironment and initiating efficient antitumor immune responses are critical for immunotherapy of MSS-CRC. According to the analysis of clinical samples, it is found that the levels of fat mass and obesity-associated protein (FTO) and M2-like tumor-associated macrophages (TAMs) infiltration are significantly elevated in CRC tissue, which has driven one to construct a targeted cationic liposome to simultaneously enhance the RNA methylation and inhibit the CD47 immune checkpoint expression of tumor cells in the hope of promoting the M1-like TAMs polarization and phagocytosis. By upregulating the m6A modification of tumor cells, the lactate secretion is decreased to promote the TAMs repolarized into M1-like. Meanwhile, CD47 siRNA codelivered by the cationic liposomes downregulates the expression of immune checkpoint CD47 on the cancer cell surface, which enhances the phagocytic ability of the M1-like TAMs. The combination treatment scheme is expected to provide a new option for treating MSS-CRC, which may also be extended for treating other immunologically “cold” tumors.","PeriodicalId":21841,"journal":{"name":"Small Structures","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141552069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hematopoietic Function Restoration by Transplanting Bone Marrow Niches In Vivo Engineered Using Carbonate Apatite Honeycomb Bioreactors 通过移植利用碳酸盐磷灰石蜂巢生物反应器设计的体内骨髓龛恢复造血功能

Small Structures Pub Date : 2024-06-19 DOI: 10.1002/sstr.202400065

Koichiro Hayashi, Ryo Kishida, Akira Tsuchiya, Kunio Ishikawa

{"title":"Hematopoietic Function Restoration by Transplanting Bone Marrow Niches In Vivo Engineered Using Carbonate Apatite Honeycomb Bioreactors","authors":"Koichiro Hayashi, Ryo Kishida, Akira Tsuchiya, Kunio Ishikawa","doi":"10.1002/sstr.202400065","DOIUrl":"https://doi.org/10.1002/sstr.202400065","url":null,"abstract":"Hematopoietic stem cell (HSC) transplantation is used to treat blood and immunodeficient diseases. HSC expansion techniques must be developed to prevent complications and ensure reliable therapeutic efficacy. Hence, several studies have attempted in vitro expansion of HSCs using scaffolds but failed to mimic the diverse and complex nature of HSC environments. Herein, an artificial HSC microenvironment, bone marrow (BM) niches is created, through in vivo engineering using carbonate apatite honeycomb scaffolds and the potential of these scaffolds in restoring lost hematopoietic function and immunity is investigated. BM niches are generated in every honeycomb channel, wherein HSCs are gradually aggregated. Compared to the actual BM, the scaffolds exhibit a 9.9- and 78-fold increase in the number of stored CD45− CD34+ side scatterlow cells that are mainly considered HSCs at 8 and 12 weeks, respectively. The transplantation of the honeycomb scaffold containing HSCs and BM niches into immunocompromised mice increases peripheral blood chimerism and restores hematopoietic function and the number of immunocytes (monocytes and lymphocytes) to normal levels. This study contributes to the development of efficient HSC transplantation techniques. Additionally, in vivo-engineered integrated tissues using honeycomb scaffolds can be used to elucidate the interplay between the BM niches and resident cells.","PeriodicalId":21841,"journal":{"name":"Small Structures","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141552070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Magnetically Guided Theranostics: Novel Nanotubular Magnetic Resonance Imaging Contrast System Using Halloysite Nanotubes Embedded with Iron–Platinum Nanoparticles for Hepatocellular Carcinoma Treatment 磁导治疗学：利用嵌入铁-铂纳米粒子的海泡石纳米管治疗肝细胞癌的新型纳米管磁共振成像对比系统

Small Structures Pub Date : 2024-06-17 DOI: 10.1002/sstr.202300526

Ming-Hsien Chan, Chi-Yu Lee, Chien-Hsiu Li, Yu-Chan Chang, Da-Hua Wei, Michael Hsiao

{"title":"Magnetically Guided Theranostics: Novel Nanotubular Magnetic Resonance Imaging Contrast System Using Halloysite Nanotubes Embedded with Iron–Platinum Nanoparticles for Hepatocellular Carcinoma Treatment","authors":"Ming-Hsien Chan, Chi-Yu Lee, Chien-Hsiu Li, Yu-Chan Chang, Da-Hua Wei, Michael Hsiao","doi":"10.1002/sstr.202300526","DOIUrl":"https://doi.org/10.1002/sstr.202300526","url":null,"abstract":"Halloysite nanotubes (HNTs) have a layered structure of clay silicate minerals and a tubular shape, which is suitable for the uniform loading of small substrates and drug molecules. The inner diameter of HNTs with an acidic solvent is selectively etched to increase the loading capacity of magnetic iron–platinum (FePt) nanoparticles. The FePt nanoparticles and etched HNTs (eHNT) are then composited by vacuum decompression. The resulting product is named FePt@eHNT and is used as a contrast agent for T2-weighted magnetic resonance imaging. According to a comprehensive analysis of the material and its magnetic properties, by adding different proportions of HNTs before and after modification, the saturation magnetization can reach 23.769 emu g−1, which is higher than that of the composite materials studied in previous studies. This is because the tubular structure promotes the orderly displacement of the FePt nanoparticles under three-dimensional space constraints and the uniform effect of the magnetic field. In addition, the magnetothermal effect of the composite material is observed and its potential as an imaging agent is investigated. In this study, the enhancement of its ferromagnetism and its potential to become a multifunctional composite material for applications in drug delivery, magnetic hyperthermia, and bioimaging is demonstrated.","PeriodicalId":21841,"journal":{"name":"Small Structures","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141530590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

On the Photothermal Response of DNA–Au Core/Shell Nanotoroids as Potential Agents for Photothermal Therapies 论 DNA-Au 核/壳纳米多面体作为光热疗法潜在药物的光热反应

Small Structures Pub Date : 2024-06-17 DOI: 10.1002/sstr.202300523

Javier González-Colsa, Anton Kuzyk, Pablo Albella

{"title":"On the Photothermal Response of DNA–Au Core/Shell Nanotoroids as Potential Agents for Photothermal Therapies","authors":"Javier González-Colsa, Anton Kuzyk, Pablo Albella","doi":"10.1002/sstr.202300523","DOIUrl":"https://doi.org/10.1002/sstr.202300523","url":null,"abstract":"Plasmonic nanoparticles play a pivotal role in various research areas due to their exceptional optical and thermo-optical properties, like high spectral tunability and efficient light-to-heat conversion. Gold, with its biocompatibility, low cytotoxicity, and tunable resonances , makes gold nanoparticles ideal for photothermal therapies. Geometries, including spheres, core–shells, rods, disks, stars, nanocages, and nanotoroids, are extensively studied, with the gold nanodoughnut emerging as one of the most promising ones due to its ability to produce high temperatures and rotational stability. Nevertheless, the fabrication of metallic toroidal shapes remains a challenge. Recent advances in DNA-based nanotechnology, especially DNA-origami techniques, provide feasible route for the fabrication of this geometry through metallization reactions or attachment of metal nanoparticles. However, particles manufactured using this method possess a DNA core that influences their thermoplasmonic performance. In this work, a theoretical investigation is conducted on the thermoplasmonic response of DNA-origami-based core/shell toroids (CSTs) for photothermal applications. Key parameters that optimize the CST thermoplasmonic response are identified, and compared with their solid counterparts and discrete metallic coatings. Additionally, the CSTs tolerance to random rotations is assessed, providing insights into their behavior in fluidic environments and implications for its practical consideration.","PeriodicalId":21841,"journal":{"name":"Small Structures","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141552073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Enoki‐Inspired Microfibers and Extracellular Matrix Enhance Biaxially Interlocking Interfaces 金针菇启发的微纤维和细胞外基质增强了双轴互锁界面

Small Structures Pub Date : 2024-06-13 DOI: 10.1002/sstr.202400193

Huy Quang Tran, Navatha Shreem Polavaram, Zishuo Yan, Donghee Lee, Yizhu Xiao, SM Shatil Shahriar, Zheng Yan, Jingwei Xie

{"title":"Enoki‐Inspired Microfibers and Extracellular Matrix Enhance Biaxially Interlocking Interfaces","authors":"Huy Quang Tran, Navatha Shreem Polavaram, Zishuo Yan, Donghee Lee, Yizhu Xiao, SM Shatil Shahriar, Zheng Yan, Jingwei Xie","doi":"10.1002/sstr.202400193","DOIUrl":"https://doi.org/10.1002/sstr.202400193","url":null,"abstract":"Taking inspiration from diverse interlocking and adhesion structures found in nature, a biaxially interlocking interface is developed in this work. This interface is formed by interconnecting two electrostatically flocked substrates and its mechanical strength is enhanced through the incorporation of enoki‐mushroom‐shaped microfibers and deposited extracellular matrix (ECM). Tips of flocked straight fibers can be transformed into mushroom shapes through thermal treatment. The tensile strength of interlocked scaffolds with mushroom‐shaped tips drastically increases when compared to scaffolds made of straight fibers, which is not reported previously. More cells proliferate within interlocked scaffolds with mushroom‐shaped tips than scaffolds with straight fibers. Additionally, the mechanical strength (e.g., compressive, tensile, and shear) of cell‐seeded interlocked scaffolds increases proportionally to the amount of ECM deposited by dermal fibroblasts. The biaxially interlocking interface developed in this study holds promise for applications in engineering interfacial tissues, modeling tissue interfaces, investigating tissue–tissue interactions, and facilitating tissue bridging or binding.","PeriodicalId":21841,"journal":{"name":"Small Structures","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141345828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Optical Laser Tweezer‐Directed Single Particle Solvatochromism of Conjugated Polydiacetylene 光学激光镊子引导的共轭聚二乙烯单粒子溶色作用

Small Structures Pub Date : 2024-06-13 DOI: 10.1002/sstr.202400171

Seung Soo Shin, Dong Yun Kim, Kwangmin Bae, Hyemin Kang, So Jung Ha, Aditya Patil, Jong-Man Kim, Bum Jun Park

引用次数: 0

Intercalation‐Conversion Hybrid Cathode Enabled by MXene‐Driven TiO2/TiS2 Heterostructure for High‐Energy‐Density Li–S Battery 利用 MXene 驱动的 TiO2/TiS2 异质结构实现互钙-转换混合负极，用于高能量密度锂离子电池

Small Structures Pub Date : 2024-06-13 DOI: 10.1002/sstr.202400196

V. Nguyen, Yusra Qureshi, H. Shim, J. Yuk, Jae-Hyun Kim, Seung‐Mo Lee

{"title":"Intercalation‐Conversion Hybrid Cathode Enabled by MXene‐Driven TiO2/TiS2 Heterostructure for High‐Energy‐Density Li–S Battery","authors":"V. Nguyen, Yusra Qureshi, H. Shim, J. Yuk, Jae-Hyun Kim, Seung‐Mo Lee","doi":"10.1002/sstr.202400196","DOIUrl":"https://doi.org/10.1002/sstr.202400196","url":null,"abstract":"A dense electrode with high sulfur loading is a straightforward approach to increasing the energy density of lithium–sulfur battery (LSB), but the development of dense electrodes suffers from both fabrication challenges and electron/ion transport limitations. In addition, the shuttle effect of soluble lithium polysulfides and sluggish reaction kinetics cause declined utilization efficiency of the active material and poor cycling stability. Herein, a dense intercalation‐conversion hybrid cathode is prepared using MXene‐driven TiS2 nano‐needles decorated with TiO2 nanoparticles. The TiO2/TiS2 heterostructure simultaneously possessing a high adsorption capability (TiO2) and bidirectional electrocatalytic effect (TiS2) is observed to effectively suppress lithium polysulfide shuttling and facilitate the sulfur conversion reactions. Furthermore, it is believed that TiS2 provides additional capacity from the intercalation reaction and functions as a multichannel network to feed both Li+/e− to the active sulfur material due to its high electronic and ionic conductivities. Thanks to these synergistic effects, the LSB assembled using the TiO2/TiS2 heterostructure exhibits high gravimetric and volumetric energy densities of 331 Wh kg−1 and 730 Wh L−1, respectively, as well as superior cyclability at a high sulfur mass loading of 7.5 mg cm−2 and lean electrolyte of 2.5 μL mg−1.","PeriodicalId":21841,"journal":{"name":"Small Structures","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141348004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hybrid Piezoresistive 2D MoS2/PEGDA/PANI Covalent Hydrogels for the Sensing of Low‐to‐Medium Pressure 用于传感中低压的混合压阻性二维 MoS2/PEGDA/PANI 共价水凝胶

Small Structures Pub Date : 2024-06-13 DOI: 10.1002/sstr.202400131

Sara Domenici, Sara Micheli, M. Crisci, Marcus Rohnke, Hannes Hergert, Marco Allione, Mengjiao Wang, Bernd Smarlsy, Peter J. Klar, Francesco Lamberti, Elisa Cimetta, L. Ceseracciu, Teresa Gatti

{"title":"Hybrid Piezoresistive 2D MoS2/PEGDA/PANI Covalent Hydrogels for the Sensing of Low‐to‐Medium Pressure","authors":"Sara Domenici, Sara Micheli, M. Crisci, Marcus Rohnke, Hannes Hergert, Marco Allione, Mengjiao Wang, Bernd Smarlsy, Peter J. Klar, Francesco Lamberti, Elisa Cimetta, L. Ceseracciu, Teresa Gatti","doi":"10.1002/sstr.202400131","DOIUrl":"https://doi.org/10.1002/sstr.202400131","url":null,"abstract":"Wearable technologies are attracting increasing attention in the materials science field, prompting a quest for active components with beneficial functional attributes whilst ensuring human and environmental safety. Hydrogels are highly biocompatible platforms with interesting mechanical properties, which can be exploited for the construction of strain sensors. In order to improve the directionality of their strain response and combine it with electrical properties to fabricate piezoresistive devices, it is possible to incorporate various types of nanofillers within the polymeric network of the hydrogels. 2D materials are ideal nanofillers thanks to their intrinsic two‐dimensional anisotropy and unique electronic properties. Herein, the covalent functionalization of 2D 1T‐MoS2 is exploited to build robust hybrid cross‐linked networks with a polyethylene glycol diacrylate gel (PEGDA). The conductivity of this nanocomposite is also further improved by inducing the interfacial polymerization of aniline. The resulting free‐standing samples demonstrate a linear and highly reversible piezoresistive response in a pressure range compatible with that of peripheral blood, while also featuring good compatibility with human skin cells, thereby making them interesting options for incorporation into wearable strain sensors.","PeriodicalId":21841,"journal":{"name":"Small Structures","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141348063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reducing Ohmic Resistances in Membrane Capacitive Deionization Using Micropatterned Ion‐Exchange Membranes, Ionomer Infiltrated Electrodes, and Ionomer‐Coated Nylon Meshes 使用微图案离子交换膜、离子聚合物浸润电极和离子聚合物涂层尼龙网降低膜电容式去离子过程中的欧姆电阻

Small Structures Pub Date : 2024-06-10 DOI: 10.1002/sstr.202400090

Mahmudul Hasan, Bharat Shrimant, Colton Burke Waters, C. Gorski, C. Arges

{"title":"Reducing Ohmic Resistances in Membrane Capacitive Deionization Using Micropatterned Ion‐Exchange Membranes, Ionomer Infiltrated Electrodes, and Ionomer‐Coated Nylon Meshes","authors":"Mahmudul Hasan, Bharat Shrimant, Colton Burke Waters, C. Gorski, C. Arges","doi":"10.1002/sstr.202400090","DOIUrl":"https://doi.org/10.1002/sstr.202400090","url":null,"abstract":"\u0000Membrane capacitive deionization (MCDI) is an emerging water desalination platform that is compact, electrified, and does not require high‐pressure piping. Herein, highly conductive poly(phenylene alkylene) ion‐exchange membranes (IEMs) are micropatterned with different surface geometries for MCDI. The micropatterned membranes increase the interfacial area with the liquid stream leading to a 700 mV reduction in cell voltage when operating at constant current (2 mA cm−2; 2000 ppm NaCl feed) while improving the energy normalized adsorbed salt (ENAS) value by 1.4 times. Combining the micropatterned poly(phenylene alkylene) IEMs with poly(phenylene alkylene) ionomer‐filled electrodes reduces the cell voltage by 1000 mV and improves the ENAS values by 2.3 times relative to the base case. This reduction in cell voltage allows for higher current density operation (i.e., 3–4 mA cm−2) . The reduction in cell voltage is ascribed to the ameliorating ohmic resistances related to ion transport at the membrane‐process stream interface and in the carbon cloth electrode. Finally, porous ionic conductors are implemented into the spacer channel with flat and micropatterned IEM configurations and ionomer infiltrated electrodes. For the configuration with flat IEMs, the porous ionic conductor improves ENAS values across the current density regime (2–4 mA cm−2), while for micropatterned IEMs it gets improved only at 4 mA cm−2.","PeriodicalId":21841,"journal":{"name":"Small Structures","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141363687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Perspective on Crystal Structures, Synthetic Methods, and New Directions in Thermoelectric Materials 透视热电材料的晶体结构、合成方法和新方向

Small Structures Pub Date : 2024-06-10 DOI: 10.1002/sstr.202400136

M. González-Barrios, Marina Tabuyo-Martínez, David Ávila‐Brande, J. Prado‐Gonjal

引用次数: 0