Small Structures最新文献

Dual‐Network Reconfigurable Powder Adhesive With Bidirectional Synergy: Concurrent Reinforcement of Tissue Sealing and Coagulation for Hemostatic Tissue Repair 具有双向协同作用的双网络可重构粉末粘合剂：用于止血组织修复的组织密封和凝固的同步增强

Small Structures Pub Date : 2026-05-27 DOI: 10.1002/sstr.70465

Wei Zhang, Huarong Shao, Lanqing Wang, Zhaofan Yang, Y W Su, Guanyu JIN, Xiuhua Zhang, Peixue Ling, Liwei Mi, Shixian Lv, Fei Liu

{"title":"Dual‐Network Reconfigurable Powder Adhesive With Bidirectional Synergy: Concurrent Reinforcement of Tissue Sealing and Coagulation for Hemostatic Tissue Repair","authors":"Wei Zhang, Huarong Shao, Lanqing Wang, Zhaofan Yang, Y W Su, Guanyu JIN, Xiuhua Zhang, Peixue Ling, Liwei Mi, Shixian Lv, Fei Liu","doi":"10.1002/sstr.70465","DOIUrl":"https://doi.org/10.1002/sstr.70465","url":null,"abstract":"Current tissue adhesives struggle with wet adhesion and phased treatment during coagulation‐healing transitions. Here, we developed a mechano‐adaptive PAA‐NHS/PEI/Fibrin (PNPF) powder adhesive featuring a dual‐network architecture, integrating a polyelectrolyte matrix (PAA‐NHS/PEI) and fibrin network through chemical linkages and thrombin activation, which displayed remodeling ability after fragmentation of the network. Benefitting from the combination of the two networks, PNPF powder adhesive exhibited water‐absorbent self‐gelation capability and bioactive properties, encompassing both procoagulant and prohealing abilities. More concretely, the powder adhesive exhibited ultrafast and robust sealing on biological tissues via interfacial dehydration and interface coupling, with the burst pressure achieving 180.7 mmHg. By integrating its superior coagulation‐enhancing properties, the PNPF powder adhesive demonstrated notably accelerated hemostatic efficacy in both rat tail and liver injury models compared to conventional hemostatic products. Furthermore, the adhesive substantially accelerated posthemostasis tissue repair processes, establishing itself as a viable strategy for advanced wound care management.","PeriodicalId":21841,"journal":{"name":"Small Structures","volume":"7 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148305746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Subcellular Aggregation of Photosensitizers Overrides Reactive Oxygen Species Generation in Photodynamic Therapy Effects 在光动力治疗效果中，光敏剂的亚细胞聚集超越活性氧的产生

Small Structures Pub Date : 2026-01-01 DOI: 10.1002/sstr.202500716

Xinyan Lyu, Siyuan Wang, Ziyue Ye, Zhuojian Li, Ryan T. K. Kwok, Kun Zhou, Zheng Zhao, Ben Zhong Tang

{"title":"Subcellular Aggregation of Photosensitizers Overrides Reactive Oxygen Species Generation in Photodynamic Therapy Effects","authors":"Xinyan Lyu, Siyuan Wang, Ziyue Ye, Zhuojian Li, Ryan T. K. Kwok, Kun Zhou, Zheng Zhao, Ben Zhong Tang","doi":"10.1002/sstr.202500716","DOIUrl":"https://doi.org/10.1002/sstr.202500716","url":null,"abstract":"The efficacy of photodynamic therapy (PDT) is conventionally correlated with the total yield of reactive oxygen species (ROS). However, we demonstrate here that the subcellular location of ROS generation is a more critical determinant of therapeutic outcome than its absolute quantity. Using two tailored aggregation‐induced emission photosensitizers (PSs)—hydrophobic Me‐PyTPA (targeting endoplasmic reticulum, ER) and amphiphilic Sulfo‐PyTPA (anchored to the cell membrane)—we show that despite its lower ROS yield, Me‐PyTPA induces significantly higher phototoxicity. Precise ER localization enables Me‐PyTPA to trigger rapid apoptosis via ER stress, even under low‐dose white‐light irradiation. In contrast, the higher‐yielding but membrane‐restricted Sulfo‐PyTPA is less effective. Cell imaging and molecular dynamics simulations reveal that hydrophobicity dictates deep membrane penetration and ER accumulation. This work establishes a “location‐over‐yield” principle for PDT, advocating for the design of organelle‐specific PSs to maximize therapeutic efficiency.","PeriodicalId":21841,"journal":{"name":"Small Structures","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/sstr.202500716","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147920547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Enhanced Luminescence Properties of Lanthanide Metal–Organic Frameworks with Low Symmetry Structure Induced by Chiral Ligand 手性配体诱导低对称结构镧系金属有机骨架的增强发光性能

Small Structures Pub Date : 2026-01-01 DOI: 10.1002/sstr.202500514

M. Ye, Luhao Qiu, Guodan Wei, Jun Qing Wei

{"title":"Enhanced Luminescence Properties of Lanthanide Metal–Organic Frameworks with Low Symmetry Structure Induced by Chiral Ligand","authors":"M. Ye, Luhao Qiu, Guodan Wei, Jun Qing Wei","doi":"10.1002/sstr.202500514","DOIUrl":"https://doi.org/10.1002/sstr.202500514","url":null,"abstract":"Luminescent complexes of lanthanide ions and organic ligands have been extensively studied. However, limited attention has been given to the effect of the lanthanide coordination environment on their fluorescence. Chiral ligands, characterized by their low symmetry, provide an effective approach to inducing asymmetry in coordination structures. This study explores how low‐symmetry coordination structures induced by chiral ligands, enhance the luminescent properties of lanthanide ions. We synthesized two pairs of chiral Eu lll metal–organic frameworks (MOFs): R/S–{[Eu 6 (pyr) 12 (H 2 O) 12 ] Cl 6 (H 2 O) 6 } ( 1R/1S ) and R/S–[Eu 1 (pyr) 2 (NO 3 )] ( 2R/2S ), where “pyr” refers to R/S–pyroglutamic acid. These metal‐organic frameworks (MOFs) exhibit distinct luminescent behaviors. The 1R/1S MOFs exhibit weak fluorescence intensity, short lifetimes, and low quantum yields (QYs). In contrast, the 2R/2S MOFs achieve exceptionally high‐luminescent QYs of up to 72.2%. This enhancement is attributed to the lower‐symmetry coordination structures around the Eu lll ions. Additionally, circularly polarized luminescence (CPL) experiments revealed that 2R/2S MOFs exhibit significant CPL with | g lum | values reaching up to 0.092. Our study provides a cost–effective synthesis strategy for lanthanide complexes with excellent luminescence properties.","PeriodicalId":21841,"journal":{"name":"Small Structures","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/sstr.202500514","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147914520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nanozyme‐Integrated 3D‐Printed Gradient Scaffold Rescues Redox Homeostasis for Enhanced Osteochondral Repair 纳米酶集成3D打印梯度支架修复氧化还原稳态，增强骨软骨修复

Small Structures Pub Date : 2026-01-01 DOI: 10.1002/sstr.202500413

Chuan Hu, Dingqi Xie, Jianyi Li, Yang Jin, Jiechao Xia, Gu Jin, Lin Ye, Zhijun Hu

引用次数: 0

A‐Site Doping Enables Stabilization and Migration of Oxygen Vacancies in Langasite Frameworks A位掺杂使Langasite框架中氧空位稳定和迁移

Small Structures Pub Date : 2025-12-31 DOI: 10.1002/sstr.202500633

Yang Chen, Zhaoji Luo, Xiaohui Li, C. Li, Sihao Deng, Lunhua He, Qiang Li, Xianran Xing, Xiaojun Kuang

{"title":"A‐Site Doping Enables Stabilization and Migration of Oxygen Vacancies in Langasite Frameworks","authors":"Yang Chen, Zhaoji Luo, Xiaohui Li, C. Li, Sihao Deng, Lunhua He, Qiang Li, Xianran Xing, Xiaojun Kuang","doi":"10.1002/sstr.202500633","DOIUrl":"https://doi.org/10.1002/sstr.202500633","url":null,"abstract":"Open‐framework oxides are promising oxide‐ion conducting candidates for next‐generation solid oxide fuel cells (SOFCs) owing to their ability to accommodate and transport oxygen defects. Here, we demonstrate that strategic A‐site substitution with Sr 2+ in the langasite framework La 3‐ x Sr x Ga 5 GeO 14‐ x /2 effectively introduces oxygen‐vacancy migration, with enhanced oxide‐ion conductivity of 3.08 × 10 −4 S/cm at 1000°C. Neutron powder diffraction (NPD), pair distribution function (PDF) analysis combined with reverse Monte Carlo (RMC) modeling, and static lattice calculations, reveal that oxygen vacancies induced by Sr doping were stabilized by local structural relaxation involving only the surrounding GaO 4 units transforming into GaO 5 coordination environments through edge‐sharing, whereas GaO 6 units and GeO 4 units largely preserve their original geometries. Complementary bond valence site energy calculations and molecular dynamics simulations further uncover the migration mechanism, revealing that oxide‐ion transport proceeds predominantly through two‐dimensional long‐range diffusion within the ab plane, with dynamic participation of all the crystallographic oxygen sites. This work establishes A‐site doping in langasites as a viable route for stabilizing oxygen defects and promoting their migration, offering fundamental insights into the design of high‐performance oxide‐ion conductors.","PeriodicalId":21841,"journal":{"name":"Small Structures","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/sstr.202500633","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147907216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Peptide‐Peptide Nucleic Acid Hybrid Hydrogel Based on Sequence Programmable Morphological Change for DNA Data Storage 基于序列可编程形态变化的肽-肽核酸杂交水凝胶用于DNA数据存储

Small Structures Pub Date : 2025-12-31 DOI: 10.1002/sstr.202500681

Huiling Lei, Jinsheng Li, Zixiao Zhang, Zi’an Lin, Guangxu Zhang, Jianjian Huang, Shuhan Dai, Guojiao Wu, Hongmei Liu, Yuzhou Wu

{"title":"Peptide‐Peptide Nucleic Acid Hybrid Hydrogel Based on Sequence Programmable Morphological Change for DNA Data Storage","authors":"Huiling Lei, Jinsheng Li, Zixiao Zhang, Zi’an Lin, Guangxu Zhang, Jianjian Huang, Shuhan Dai, Guojiao Wu, Hongmei Liu, Yuzhou Wu","doi":"10.1002/sstr.202500681","DOIUrl":"https://doi.org/10.1002/sstr.202500681","url":null,"abstract":"Peptide‐based hydrogels provide biocompatible, stimuli‐responsive platforms, while peptide‐DNA hybrids extend programmability through hybridization‐driven crosslinking. However, nucleobase incorporation can influence peptide self‐assembly pathways. We demonstrate that the introduction of bases can directly alter the transition of peptides between gel and solution, offering an alternative mechanism to hybridization‐dependent approaches. Using peptide nucleic acid–guanine as a molecular bridge, guanine attachment shifts peptide assemblies from gel to solution states. Conversely, introducing complementary cytosine‐rich DNA sequences triggers a solution‐to‐gel transition. This morphological switching is sequence‐specific, enabling precise spatiotemporal control of gelation. Structural and rheological analyses confirm guanine's critical role in altering peptide backbone organization and enabling dynamic reconfiguration. As a demonstration of this programmable material's capabilities, we applied the hydrogel for DNA data storage. The hydrogel protects encapsulated DNA information from enzymatic degradation and facilitates precise digital information retrieval, establishing a robust storage medium for synthetic DNA‐encoded data. This strategy leverages nucleic acid sequence specificity to directly manipulate peptide nanostructure, advancing the design of smart, stimuli‐responsive biomaterials.","PeriodicalId":21841,"journal":{"name":"Small Structures","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/sstr.202500681","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147888013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Waterproof, Moisture‐Resistant, and Breathable Full‐Textile Iontronic Capacitive Pressure Sensor for Wearable Physiological Monitoring 防水，防潮，透气，全纺织离子电容式压力传感器，用于穿戴式生理监测

Small Structures Pub Date : 2025-12-29 DOI: 10.1002/sstr.202500745

Qingxian Liu, Wengui Lin, Jingyi Yang, Wenheng Huang, Y. Zhu, Yifei Li, L. Liao, Longsi Rao, Jinlong Liu, Zhiguang Liu, Quan Wang

{"title":"Waterproof, Moisture‐Resistant, and Breathable Full‐Textile Iontronic Capacitive Pressure Sensor for Wearable Physiological Monitoring","authors":"Qingxian Liu, Wengui Lin, Jingyi Yang, Wenheng Huang, Y. Zhu, Yifei Li, L. Liao, Longsi Rao, Jinlong Liu, Zhiguang Liu, Quan Wang","doi":"10.1002/sstr.202500745","DOIUrl":"https://doi.org/10.1002/sstr.202500745","url":null,"abstract":"Flexible iontronic capacitive pressure sensors enable precise and continuous monitoring of weak physiological signals owing to their high sensing capability, making them promising candidates for wearable health monitoring systems. However, such wearable iontronic pressure sensors, which retain a porous structure to ensure high breathability, inevitably experience significant signal drift and compromised operational stability caused by water or moisture penetration in practical applications. Herein, a fully textile‐based iontronic capacitive pressure sensor with a hydrophobic‐hydrophilic‐hydrophobic structure is proposed to address this challenge. In this design, the outer hydrophobic layer prevents external water penetration, and the middle hydrophilic layer absorbs moisture, while the inner hydrophobic layer blocks the absorbed moisture from reaching the sensing layer. This structure endows our pressure sensor with waterproofness, moisture resistance, and breathability, while the integration of a cotton fabric/poly(vinylidene fluoride‐co‐hexafluoropropylene) (PVDF‐HFP)/ionic liquid (IL) sensing layer significantly enhances its sensing performance. It exhibits a sensitivity of 11.61 kPa −1 and a fast response of 30 ms, while maintaining low signal drift in water and high‐moisture environments. Furthermore, the textile‐based structure allows the sensor to be breathable, improving wearable applicability. Such an iontronic pressure sensor exhibits great potential in pulse signal monitoring, serving as a feasible platform for wearable health monitoring systems.","PeriodicalId":21841,"journal":{"name":"Small Structures","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/sstr.202500745","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147891403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Flexoelectric Polarization‐Enhanced Gd‐Based Nanoflowers for Efficient Phosphatase‐Mimicking Dephosphorylation 柔性电极化增强的基于Gd的纳米花用于高效磷酸酶模拟去磷酸化

Small Structures Pub Date : 2025-10-20 DOI: 10.1002/sstr.202500559

Linjing Su, Jingyan Xu, Rong Huang, Jinlan Liao, Lingyan Zhao, Ling Li, Zhi Zhang, Yuhao Xiong

{"title":"Flexoelectric Polarization‐Enhanced Gd‐Based Nanoflowers for Efficient Phosphatase‐Mimicking Dephosphorylation","authors":"Linjing Su, Jingyan Xu, Rong Huang, Jinlan Liao, Lingyan Zhao, Ling Li, Zhi Zhang, Yuhao Xiong","doi":"10.1002/sstr.202500559","DOIUrl":"https://doi.org/10.1002/sstr.202500559","url":null,"abstract":"Phosphatase‐mimicking nanozymes provide highly stable enzyme‐like activity but remain limited by their static catalytic nature. Herein, this study achieves flexoelectricity‐driven dynamic modulation of nanozyme activity by employing gadolinium‐based nanoflowers (GNF) with hierarchical ultrathin architectures. These structures possess curvature‐induced strain gradients and hydroxyl‐rich surfaces, which generate pronounced flexoelectric polarization under mild ultrasonic excitation. Finite element simulations reveal that mechanical loading induces localized strain gradients and surface potential anisotropy, forming a structural basis for dynamic interfacial charge redistribution. Density functional theory calculations demonstrate that flexoelectric polarization lowers the activation barrier and shifted the rate‐determining step, transforming the reaction pathway. This polarization enhances the Lewis acidity of Gd 3+ sites and stabilized transition states, thereby accelerating phosphate ester hydrolysis. The GNF nanozyme exhibits excellent phosphatase‐like catalytic activity and enables the ultrasensitive colorimetric detection of biologically relevant targets, such as bovine serum albumin and fluoride ions, with low detection limits and robust matrix tolerance. This study pioneers the integration of strain‐gradient‐induced polarization into nanozyme catalysis, establishing a generalizable framework for constructing adaptive and mechanically responsive artificial enzymes.","PeriodicalId":21841,"journal":{"name":"Small Structures","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/sstr.202500559","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147334072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Dynamic Network Reconfiguration Toward Mechanically Robust Polymeric Foam via Ice Templating 通过冰模板实现机械坚固性聚合物泡沫的动态网络重构

Small Structures Pub Date : 2025-10-17 DOI: 10.1002/sstr.202500570

Chenggang Xu, Xing‐Qun Pu, Runzhi Lu, Yongbo Jiang, Qian Zhao, Zizheng Fang, Tao Xie

{"title":"Dynamic Network Reconfiguration Toward Mechanically Robust Polymeric Foam via Ice Templating","authors":"Chenggang Xu, Xing‐Qun Pu, Runzhi Lu, Yongbo Jiang, Qian Zhao, Zizheng Fang, Tao Xie","doi":"10.1002/sstr.202500570","DOIUrl":"https://doi.org/10.1002/sstr.202500570","url":null,"abstract":"Polymeric foams have garnered significant interest in advanced engineering applications due to their unique porous architectures. Ice templating represents a promising strategy for creating polymeric foams with tunable pore morphology, yet faces practical constraints including reliance on energy‐intensive lyophilization and/or insufficient mechanical properties of the resulting foams. To address this challenge, a strategy is developed to prepare mechanically robust polymeric foams by photo‐crosslinking ice‐templated emulsions. By incorporating dynamic hindered urea bonds into the emulsion, dynamic network reconfiguration is achieved, which dramatically improves mechanical properties. The resultant foam (≈65% porosity) exhibits tensile strength and breaking strains of 7.9 MPa and 533%, with toughness of 15.8 MJ m −3 . In addition, this strategy permits the construction of intricate 3D architectures using 3D‐printed sacrificial thermoplastic templates, expanding their potential applications in demanding engineering scenarios.","PeriodicalId":21841,"journal":{"name":"Small Structures","volume":"6 12","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/sstr.202500570","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147332776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Brain‐Targeted Multifunctional Liposomes Reprogram Microglia via Anti‐Inflammatory Signaling and Reactive Oxygen Species Scavenging to Treat Post‐Traumatic Neuroinflammation 脑靶向多功能脂质体通过抗炎信号和活性氧清除重编程小胶质细胞治疗创伤后神经炎症

Small Structures Pub Date : 2025-10-17 DOI: 10.1002/sstr.202500270

Xuan Wang, Zhiqi Hu, Youbo Zhao, Fei Yang, Menghuan Li, Min Su, Zhong Luo, Rong Hu

{"title":"Brain‐Targeted Multifunctional Liposomes Reprogram Microglia via Anti‐Inflammatory Signaling and Reactive Oxygen Species Scavenging to Treat Post‐Traumatic Neuroinflammation","authors":"Xuan Wang, Zhiqi Hu, Youbo Zhao, Fei Yang, Menghuan Li, Min Su, Zhong Luo, Rong Hu","doi":"10.1002/sstr.202500270","DOIUrl":"https://doi.org/10.1002/sstr.202500270","url":null,"abstract":"Traumatic brain injuries (TBIs) are often accompanied by severe neuroinflammation that markedly elevates the risk of neurodegeneration and cognitive impairment. Current insights reveal that the excessive accumulation of inflammatory microglial cells drives TBI‐associated inflammatory responses. However, inhibiting neuroinflammation through reprograming microglial cells is challenging as the blood‐brain barrier (BBB) severely impedes delivery of anti‐inflammatory drugs. To address these challenges, a nanointegrative TBI treatment strategy is reported that can reprogram inflammatory microglial cells into a reparative phenotype for abolishing post‐TBI neurodegeneration. Herein, methylprednisolone and Tempol are loaded into transactivator of transcription (TAT) peptide‐modified PEGylated liposomes to afford a liposomal microglial reprogramming platform (LMRP). After intravenous administration, the liposomes efficiently cross the BBB and accumulate in TBI sites to release the therapeutic payload, which cooperatively activates multiple anti‐inflammatory signaling pathways and scavenged reactive oxygen species for repolarizing inflammatory microglial cells to reparative phenotypes in situ, leading to effective amelioration of the neurodegeneration symptoms. In vivo analysis shows that LMRP treatment robustly recovers the neurological functions of TBI rat models with no obvious side effects, offering an approach for TBI treatment with clinical promise.","PeriodicalId":21841,"journal":{"name":"Small Structures","volume":"6 12","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/sstr.202500270","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147884981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1