Small Structures最新文献_第2页

Dual‐Interface Symmetrical‐Structure Solar Evaporators with Overturning Controllable Salt for High‐Efficiency Desalination 用于高效海水淡化的双界面对称结构可翻转盐太阳能蒸发器

Small Structures Pub Date : 2025-10-13 DOI: 10.1002/sstr.202500543

Jiugang Li, Jiugang Li, Haoran Qiao, Wenqi Zhang, Zhiqiang Wang, Renyi Wu, Yi Hu, Kerun Hua, Wenbin Li, Jiahao He, Jiuyi Li, Jiuyi Li

{"title":"Dual‐Interface Symmetrical‐Structure Solar Evaporators with Overturning Controllable Salt for High‐Efficiency Desalination","authors":"Jiugang Li, Jiugang Li, Haoran Qiao, Wenqi Zhang, Zhiqiang Wang, Renyi Wu, Yi Hu, Kerun Hua, Wenbin Li, Jiahao He, Jiuyi Li, Jiuyi Li","doi":"10.1002/sstr.202500543","DOIUrl":"https://doi.org/10.1002/sstr.202500543","url":null,"abstract":"Solar interfacial evaporation holds significant promise for sustainable desalination, but its long‐term performance and practical deployment are often hindered by salt accumulation and maintenance requirements. To overcome these limitations, a cotton fabric MoS 2 composite is synthesized by applying a MoS 2 /dopamine mixture dissolved in water–alcohol solution onto cotton fabrics. This composite is engineered into a dual‐interface symmetrical‐structure solar fabric evaporator (DS‐SFE) with self‐cleaning and salt‐removal capabilities, enabling efficient evaporation of high‐salinity brine. DS‐SFE achieves 95.5% solar absorption and 40.0 kg m −2 water supply flux. Under 1 sun illumination, the evaporation rate in deionized water reaches 2.25 kg m −2 h −1 . Even in a 15 wt% NaCl solution, stable and excellent evaporation performance (1.75 kg m −2 h −1 ) can still be maintained. The flip‐design establishes easy operation in extreme salinity (20 wt% NaCl), requiring only manual rotation every 8 h to clear accumulated salt and ensure continuous operation. This work advances eco‐friendly solar evaporator design, demonstrating scalable potential for sustainable water purification.","PeriodicalId":21841,"journal":{"name":"Small Structures","volume":"6 12","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/sstr.202500543","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147906087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Quasi‐Bound States in the Continuum Supported in Titanium Oxide Metasurfaces with Nanoslits Fabricated by Thermal Oxidation 热氧化法制备纳米缝隙的氧化钛超表面中连续介质的准束缚态

Small Structures Pub Date : 2025-09-23 DOI: 10.1002/sstr.202500366

Zhipeng Hu, Houxin Fan, Yuwei Sun, Zhenchao Liu, Yi Jin, Sailing He

{"title":"Quasi‐Bound States in the Continuum Supported in Titanium Oxide Metasurfaces with Nanoslits Fabricated by Thermal Oxidation","authors":"Zhipeng Hu, Houxin Fan, Yuwei Sun, Zhenchao Liu, Yi Jin, Sailing He","doi":"10.1002/sstr.202500366","DOIUrl":"https://doi.org/10.1002/sstr.202500366","url":null,"abstract":"Recent advances in titanium oxide (TiO 2 ) nanophotonics have highlighted this material's exceptional potential for low‐loss visible and near‐infrared photonic applications, yet challenges in microstructuring have hindered its broader adoption. Herein, a transformative approach for creating subwavelength TiO 2 structures through controlled thermal oxidation of titanium (Ti) is demonstrated. Spectroscopic characterization confirms that the oxide product exhibits excellent behavior, closely resembling that of natural TiO 2 , and the geometrical extension of the subwavelength structures during the oxidation can be precisely predicable following some found rules. As a demonstration, a metasurface consisting of a periodic array of slitted TiO 2 disks supporting a quasi‐bound state in the continuum to enhance fluorescence is designed and fabricated, and the experimental result is well consistent with the theoretical prediction. It is striking that the width of the slits may be reduced below 10 nm, difficult for conventional top‐down fabrication methods, and the quality factor of the resonant metasurface can reach the level of 1000. This oxidation‐mediated nanofabrication strategy is valuable for forming sub‐10 nm gaps and establishes a potential pathway for large‐scale, cost‐effective production of subwavelength TiO 2 devices.","PeriodicalId":21841,"journal":{"name":"Small Structures","volume":"6 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/sstr.202500366","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147913375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

HA Self‐Assembled Dual‐Drug‐Loaded Nanoparticles: Integrating Multitargeted Tumor Therapy and Immune Microenvironment Remodeling via Phototherapy and Apoptosis 透明质酸自组装双药物负载纳米颗粒：通过光疗和细胞凋亡整合多靶点肿瘤治疗和免疫微环境重塑

Small Structures Pub Date : 2025-09-18 DOI: 10.1002/sstr.202500452

Lixuan Zang, Haomiao Zhu, Bohan Chen, Feng Sun, Jinhua Zhang, Huarong Shao, Yishu Wang, Fei Liu, Haining Tan, Peixue Ling

{"title":"HA Self‐Assembled Dual‐Drug‐Loaded Nanoparticles: Integrating Multitargeted Tumor Therapy and Immune Microenvironment Remodeling via Phototherapy and Apoptosis","authors":"Lixuan Zang, Haomiao Zhu, Bohan Chen, Feng Sun, Jinhua Zhang, Huarong Shao, Yishu Wang, Fei Liu, Haining Tan, Peixue Ling","doi":"10.1002/sstr.202500452","DOIUrl":"https://doi.org/10.1002/sstr.202500452","url":null,"abstract":"Activating the mitochondrial apoptosis pathway cancer therapy holds significant theoretical and clinical implications in cancer therapy. However, the complex regulation of tumorigenesis limits the efficacy of single‐target therapeutic approaches. This article introduces a novel antitumor nanoparticle (ICG‐HA‐ADH‐CBA‐TATKLA, IHTK), which combines glycosaminoglycan (hyaluronic acid, HA), proapoptotic fusion peptide (TAT‐KLA), and photothermal/photodynamic agent (indocyanine green, ICG). The nanoparticle enables precise tumor targeting and enhance ICG accumulation, generating substantial reactive oxygen species under near‐infrared irradiation. This process upregulates damage‐associated molecular patterns, including ATP, calreticulin (CRT), and HMGB1, to induce immunogenic cell death. Consequently, immune cell infiltration is promoted, and the tumor microenvironment (TME) is remodeled. Furthermore, the acidic TME triggers the release of TAT‐KLA (TK) through the nanoparticle's pH‐responsiveness, facilitating the rapid mitochondrial localization of TK. This mechanism disrupts mitochondrial membrane potential, enhances permeability, promotes Cytochrome C release, and activates caspase cascades to directly induce tumor cell apoptosis. In tumor‐bearing mice, IHTK effectively suppressed tumor progression and prolonged survival. In summary, IHTK, based on a multitarget regulation strategy, achieves TME‐responsive precision delivery, multipathway coordinated apoptosis induction, and immunomodulatory TME remodeling for synergistic therapeutic efficacy. This approach offers both a theoretical foundation and innovative insights for antitumor drug development.","PeriodicalId":21841,"journal":{"name":"Small Structures","volume":"6 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/sstr.202500452","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147897785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

High‐Temperature Energy Storage Performance of Polyetherimide‐based Composites Enhanced by Core–Shell Structured Nanofillers 核壳结构纳米填料增强聚醚酰亚胺基复合材料的高温储能性能

Small Structures Pub Date : 2025-09-12 DOI: 10.1002/sstr.202500460

Yan Guo, Ruitao Li, Weichen Zhao, Jin Qian, Tao Zhou, Wenfeng Liu, Jiwei Zhai, Yonghao Xu, Di Zhou

{"title":"High‐Temperature Energy Storage Performance of Polyetherimide‐based Composites Enhanced by Core–Shell Structured Nanofillers","authors":"Yan Guo, Ruitao Li, Weichen Zhao, Jin Qian, Tao Zhou, Wenfeng Liu, Jiwei Zhai, Yonghao Xu, Di Zhou","doi":"10.1002/sstr.202500460","DOIUrl":"https://doi.org/10.1002/sstr.202500460","url":null,"abstract":"Functioning as the fundamental building blocks of new energy power systems, high‐temperature dielectric materials critically affect device durability and efficiency under extreme conditions. However, conventional polymer composites often suffer from increased dielectric loss and reduced insulation strength at high temperatures, degrading energy storage performance and limiting high‐temperature capacitor applications. To address this, core–shell Bi 6 Ti 5 WO 22 @MgO (BTWO@MO) nanofillers via chemical precipitation are designed. The inner core BTWO demonstrates high polarizability, while the wide bandgap MgO shell effectively suppresses interfacial charge accumulation. By incorporating BTWO@MO into polyetherimide (PEI), composites with high insulation strength and low dielectric loss are achieved. Experimental results show that at 150 °C and 580 MV·m −1 , the composite achieves a remarkable discharged energy density ( U d ) of 6.24 J·cm −3 (a 197% improvement compared to pure PEI) under breakdown electric fields, with an efficiency retention of 76.35%. More importantly, at 400 MV·m −1 , the U d of the composite is 4.80 J·cm −3 , and the efficiency is as high as 87.51%. Additionally, the composite exhibits excellent cycling stability under practical operating conditions involving both elevated temperatures and strong electric fields. This study develops high‐performance high‐temperature dielectric materials through an innovative core–shell filler design, offering a novel solution for extreme‐environment dielectric applications.","PeriodicalId":21841,"journal":{"name":"Small Structures","volume":"6 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/sstr.202500460","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147906054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Bioinspired Janus Mesh with Gradient Wettability for High‐Efficiency Fog Harvesting via Synergistic Capillary Condensation and Directional Droplet Transport 具有梯度润湿性的仿生Janus网格，通过协同毛细管冷凝和定向液滴传输实现高效雾收集

Small Structures Pub Date : 2025-09-02 DOI: 10.1002/sstr.202500436

Junlan Liang, Hongde Zhu, Shaojun He, Zhiguang Guo

{"title":"Bioinspired Janus Mesh with Gradient Wettability for High‐Efficiency Fog Harvesting via Synergistic Capillary Condensation and Directional Droplet Transport","authors":"Junlan Liang, Hongde Zhu, Shaojun He, Zhiguang Guo","doi":"10.1002/sstr.202500436","DOIUrl":"https://doi.org/10.1002/sstr.202500436","url":null,"abstract":"To tackle the challenges of inadequate environmental compatibility and insufficient wettability gradient in the Janus structure used for current fog water collection. This study, inspired by Nepenthes pitcher plants, cacti, and mesophyll tissues, developed a bioinspired Janus mesh based on sodium carboxymethyl cellulose‐Ca 2+ /palmitic acid. Through ionic cross‐linking and solvent‐induced crystallization processes, an asymmetric interface with a 138° wettability gradient is constructed. By synergizing capillary condensation and Laplace pressure differences, rapid directional transport of fog droplets within 0.07 s is achieved. The Janus mesh demonstrates fog collection efficiencies of 0.72 and 1.80 g cm −2 min −1 under vertical and 15° inclined conditions, respectively, which are 2.06 and 5.1 times those of the original stainless steel mesh. This research integrates high‐efficiency water collection with environmental friendliness, offering a new paradigm for arid regions, and its design concept can be extended to other domains.","PeriodicalId":21841,"journal":{"name":"Small Structures","volume":"6 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/sstr.202500436","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147910026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Construction of NH₂‐UiO‐66@PCN‐224 Nanocomposites with Tightly Integrated Interfaces for Boosting Photocatalytic CO₂ Reduction with H₂O NH2‐UiO‐66@PCN‐224紧密集成界面纳米复合材料的构建促进H2O光催化CO2还原

Small Structures Pub Date : 2025-07-13 DOI: 10.1002/sstr.202500206

Jinglian Fan, Yiming He, Wenji Li, Zhongxing Zhao, Zhenxia Zhao

{"title":"Construction of NH2‐UiO‐66@PCN‐224 Nanocomposites with Tightly Integrated Interfaces for Boosting Photocatalytic CO2 Reduction with H2O","authors":"Jinglian Fan, Yiming He, Wenji Li, Zhongxing Zhao, Zhenxia Zhao","doi":"10.1002/sstr.202500206","DOIUrl":"https://doi.org/10.1002/sstr.202500206","url":null,"abstract":"Converting CO 2 into high‐value‐added products via “artificial photosynthesis” under mild conditions is a promising yet challenging strategy for developing efficient photocatalysts. This study reports a simple two‐step solvothermal approach to fabricate the dual‐metal–organic framework (MOF) nanocomposite NH 2 ‐UiO‐66@PCN‐224 (NU‐66@PCN‐224) with tightly integrated interfaces, which achieves efficient CO 2 to CO photocatalytic reduction under light irradiation. The epitaxially grown PCN‐224, composed of Zr 6 clusters and tetrakis (4‐carboxyphenyl) porphyrin (TCPP), serves as a shell layer and a visible light‐absorbing antenna, thereby broadening the light absorption range of the composite material. Moreover, the tightly integrated interfaces of NU‐66@PCN‐224 enhance the mobility of photogenerated charge carriers, consequently enhancing its capability for CO 2 catalytic reduction. As a result, the combination of NU‐66 and PCN‐224 retains their individual advantages while achieving a synergistic enhancement of both adsorption and catalysis, further improving the photocatalytic performance. The as‐prepared NU‐66@PCN‐224 catalyst exhibits outstanding photocatalytic performance, yielding 74.6 μmol g −1 h −1 of CO under irradiation without sacrificial agents or photosensitizers. This work demonstrates a straightforward and effective method for designing MOF‐on‐MOF photocatalysts with enhanced photoactivity.","PeriodicalId":21841,"journal":{"name":"Small Structures","volume":"6 10","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147333661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Analysis and Study of Covalent Organic Frameworks in Electrochemical Sensors for Water Environment Pollutant Detection 水环境污染物检测电化学传感器中共价有机框架的分析与研究

Small Structures Pub Date : 2025-06-16 DOI: 10.1002/sstr.202500138

Bo Long, Qi Liu, Qian Zhang, Qiongqiong Xing, Liying Deng, Fangfang Qu, Liwei Wang, Dapeng Ye, Zhanhui Yuan

{"title":"Analysis and Study of Covalent Organic Frameworks in Electrochemical Sensors for Water Environment Pollutant Detection","authors":"Bo Long, Qi Liu, Qian Zhang, Qiongqiong Xing, Liying Deng, Fangfang Qu, Liwei Wang, Dapeng Ye, Zhanhui Yuan","doi":"10.1002/sstr.202500138","DOIUrl":"https://doi.org/10.1002/sstr.202500138","url":null,"abstract":"Water is essential for life on Earth, but increased human activity has led to water pollution. The international community has been highly concerned about this issue, making it crucial to develop methods for detecting water pollutants. Recently, electrochemical sensors have emerged as effective tools for detecting environmental pollutants in water. Covalent organic frameworks (COFs), a quickly developing type of crystalline linked organic polymers, possess highly structured frameworks, significant specific surface areas, durable chemical properties, and customizable pore microenvironments, which confer great versatility. Notably, electrochemical sensors based on COFs have garnered significant attention due to their outstanding analytical performance. Herein, a comprehensive overview of the basic characteristics is provided and synthesis techniques of COFs in the field of electrochemical detection are widely used, emphasizing their role in the development of electrochemical biosensors and high response detection devices. The design principles, preparation methods, and detection mechanisms of COF‐based electrochemical sensors are also detailed. Recent scientific advancements have been examined, highlighting the application of COF as a functional material in electrochemical sensors for detecting various water pollutants, such as antibiotics, heavy metals, insecticides, bacteria, and fungi. Additionally, the challenges and future development prospects of COF‐based electrochemical detection technology have been outlined.","PeriodicalId":21841,"journal":{"name":"Small Structures","volume":"6 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147901045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Facilitated Charge Transfer Endowed by Zn–O Bridge of Phthalocyanine‐Based Hollow Tandem S‐Scheme Heterojunction for Photocatalytic Fuel Production 光催化燃料生产中酞菁基中空串联S - Scheme异质结Zn-O桥赋予的促进电荷转移

Small Structures Pub Date : 2025-06-09 DOI: 10.1002/sstr.202500166

Ping She, Xuejing Li, Shuang Xu, Shuming Li, Hui Chen, Weng‐Chon Cheong

{"title":"Facilitated Charge Transfer Endowed by Zn–O Bridge of Phthalocyanine‐Based Hollow Tandem S‐Scheme Heterojunction for Photocatalytic Fuel Production","authors":"Ping She, Xuejing Li, Shuang Xu, Shuming Li, Hui Chen, Weng‐Chon Cheong","doi":"10.1002/sstr.202500166","DOIUrl":"https://doi.org/10.1002/sstr.202500166","url":null,"abstract":"Photocatalytic CO 2 reduction (PCR) can release the issues of energy shortage and environmental pollution simultaneously. However, it is difficult to obtain satisfying PCR performance due to rapid carrier combination and limited light harvesting. Herein, facilitated charge transfer is achieved by building a Zn–O bridge at the interface of a hollow tandem heterojunction based on phthalocyanine. The optimized tandem heterojunction of molecular sulfonated cobalt phthalocyanine (CoSPc) and hollow TiO 2 @ZnIn 2 S 4 (H‐TiO 2 @ZIS/CoSPc) demonstrates the efficient photocatalytic generation of solar fuel, which is superior to pristine individual semiconductor catalysts and most reported relevant catalysts. Moreover, the hollow morphology of the heterojunction can elevate the photocatalytic performance by enhancing light absorption, exposing more active sites, and reducing the charge transfer distance. Specifically, efficient cascade charge transfer induced by the Zn–O bridge is verified by the experimental and theoretical results. The facile approach here holds great potential for designing highly efficient catalysts for solar fuel production.","PeriodicalId":21841,"journal":{"name":"Small Structures","volume":"6 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/sstr.202500166","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147918954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Kartogenin‐Loaded Aminated Hollow Mesoporous Prussian Blue Nanozyme‐Reinforced Hydrogel Remodels the Senescent Microenvironment via Reactive Oxygen Species Scavenging and Stimulator of Interferon Genes Inhibition to Promote Cartilage Regeneration 负载Kartogenin的氨化中空介孔普鲁士蓝纳米酶增强水凝胶通过活性氧清除和干扰素基因抑制刺激因子来重塑衰老微环境，促进软骨再生

Small Structures Pub Date : 2025-05-29 DOI: 10.1002/sstr.202400592

Shu‐Hang He, Zhi‐Han Shen, Ren Zhang, Po‐Lin Liu, Xuran Li, Qingsong Deng, Yuchen Zhang, Ang Wang, Xiaoqiu Dou, Shang Guo, Shi‐Cong Tao

{"title":"Kartogenin‐Loaded Aminated Hollow Mesoporous Prussian Blue Nanozyme‐Reinforced Hydrogel Remodels the Senescent Microenvironment via Reactive Oxygen Species Scavenging and Stimulator of Interferon Genes Inhibition to Promote Cartilage Regeneration","authors":"Shu‐Hang He, Zhi‐Han Shen, Ren Zhang, Po‐Lin Liu, Xuran Li, Qingsong Deng, Yuchen Zhang, Ang Wang, Xiaoqiu Dou, Shang Guo, Shi‐Cong Tao","doi":"10.1002/sstr.202400592","DOIUrl":"https://doi.org/10.1002/sstr.202400592","url":null,"abstract":"Articular cartilage defects remain an intractable clinical challenge due to the limited capacity of cartilage for self‐renewal and repair. Excessive accumulation of reactive oxygen species (ROS) leads to mitochondrial dysfunction, inflammation, and chondrocyte senescence, impeding cartilage regeneration. In this study, we developed an injectable, dual‐function hydrogel system comprising kartogenin (KGN)‐loaded aminated hollow mesoporous Prussian blue (NH 2 ‐HMPB) nanozyme (termed NH@K nanozyme) and hyaluronic acid methacrylate (HAMA). This “double sustained‐release” system prolongs the therapeutic duration of KGN while seamlessly filling irregular cartilage defects. As NH@K nanozyme is released, it scavenges ROS, reduces oxidative stress, protects mitochondrial function, inhibits cyclic GMP‐AMP synthase–stimulator of interferon genes (STING) pathway activation, and modulates inflammation and macrophage polarization, rejuvenating the senescent microenvironment. RNA sequencing analysis and in vitro experiments revealed that NH@K nanozyme modulates signaling pathways associated with chondrogenesis and inflammation, promoting cartilage repair. In a rat model, HAMA‐NH@K hydrogel significantly enhances extracellular matrix deposition and cartilage regeneration. The synergistic combination of nanozyme and hydrogel in our system enables the reshaping of the senescent microenvironment, providing a promising strategy for advanced cartilage regeneration.","PeriodicalId":21841,"journal":{"name":"Small Structures","volume":"6 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/sstr.202400592","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147885956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Machine Learning‐Assisted Pd‐Au/MXene Sensor Array for Smart Gas Identification 用于智能气体识别的机器学习辅助Pd - Au/MXene传感器阵列

Small Structures Pub Date : 2025-05-23 DOI: 10.1002/sstr.202400619

Yiheng Chen, Jiawang Hu, Nanlin Hu, Shikai Wu, Yuan Lu

{"title":"Machine Learning‐Assisted Pd‐Au/MXene Sensor Array for Smart Gas Identification","authors":"Yiheng Chen, Jiawang Hu, Nanlin Hu, Shikai Wu, Yuan Lu","doi":"10.1002/sstr.202400619","DOIUrl":"https://doi.org/10.1002/sstr.202400619","url":null,"abstract":"Smart gas identification is vital in medical, environmental, and manufacturing fields. However, traditional gas‐sensing technologies either lack portability or demand high working temperatures, devoid of in situ and instant sensing capability. In this work, Pd‐Au/MXene sensors with excellent gas‐sensing properties are fabricated utilizing an in situ growth strategy. A bionic sensor array is developed and further integrated into an instant and in situ sensing platform (IISP). Moreover, machine learning (ML) algorithms are employed to strengthen IISP's capacity for gas identification in complex application scenarios. Owing to the electron sensitization and catalysis function of noble metal sites, the Pd‐Au/MXene nanocomposite demonstrates enhanced gas‐sensing characteristics, with a response up to 2.73 times the response of pristine Ti 3 C 2 T x and a response speed 1.81 times as the pristine Ti 3 C 2 T x . In addition, the sensor array successfully distinguishes 14 odor molecules common in life by pattern recognition algorithms. Eventually, with the assistance of ML, the IISP exhibits 89.2% accuracy in detecting different food odors. Also, it achieves 92.0% accuracy in identifying the breath odor of healthy individuals and gastric cancer patients. In all, a portable, cost‐effective, and high‐performance IISP is established as a prototype, providing a promising solution for versatile gas‐sensing application scenarios.","PeriodicalId":21841,"journal":{"name":"Small Structures","volume":"6 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/sstr.202400619","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147917732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7