Sexual Medicine最新文献

{"title":"Angiotensin (1-7) decreases the fibrotic process by modulating the TGF-β1/AKT pathway in rat corpus cavernosum smooth muscle cells.","authors":"Yi Xu, Yifang Lu, Geling Liu, Chen Wang, Shuo Tian, Hongzhen Xiao, Weijuan Li","doi":"10.1093/sexmed/qfaf080","DOIUrl":"10.1093/sexmed/qfaf080","url":null,"abstract":"<p><strong>Background: </strong>Hyperglycemia induces the development of cavernosa atherosclerosis and fibrosis, and transforming growth factor-β1 (TGF-β1) plays an important role in the induction, promoting fibrosis in corporal tissue, which replaces the normal corpora cavernosa with fibrotic tissue.</p><p><strong>Aim: </strong>This study explored the role of Angiotensin (1-7) (Ang 1-7) and the regulatory mechanism underlying fibrosis in the corpora cavernosa.</p><p><strong>Methods: </strong>Primary rat corpus cavernosum smooth muscle cells (CCSMCs) were cultured under normal and high glucose (HG) with or without Ang 1-7. The protein levels of TGF-β1, Collagen I, TGF-β receptor-I (TβRI), and caveolin-1 (Cav-1) were evaluated by western blotting. Reactive oxygen species (ROS) and peroxynitrite (ONOO^-) levels in cell culture supernatants were measured by enzyme-linked immunosorbent assay. Intracellular calcium content was determined by flow cytometry.</p><p><strong>Outcomes: </strong>High glucose significantly increased the protein levels of TGF-β1 and Collagen I, triggered oxidative stress, modulated the AKT signaling pathway, and elevated intracellular calcium ion levels in CCSMCs. Angiotensin (1-7) treatment significantly attenuated HG-induced adverse effects in CCSMCs.</p><p><strong>Results: </strong>The protective effects of Ang 1-7 against fibrosis in HG-exposed CCSMCs were associated with the downregulation of TGF-β1 levels, accompanied by the attenuation of oxidative stress. The Ang1-7-induced effects in CCSMC cells are mediated through the inhibition of the TGF-β1/AKT signaling pathway.</p><p><strong>Clinical translation: </strong>Our studies provide new insights into the critical role of the TGF-β1/AKT signaling pathway in CCSMCs, identifying it as a potential therapeutic target for treating patients with erectile dysfunction.</p><p><strong>Strengths and limitations: </strong>Angiotensin (1-7) is a unique peptide of the renin-angiotensin system with substantial therapeutic potential. This study assessed the therapeutic effect of Ang 1-7 on the fibrotic process and provided new insights for clinical applications. The clinical formulation, drug stability, and <i>in vivo</i> bioactivity of Ang-1-7 remain to be fully investigated.</p><p><strong>Conclusion: </strong>Angiotensin (1-7) exerts a protective effect on CCSMCs under HG conditions by modulating the TGF-β1/AKT signaling pathway.</p>","PeriodicalId":21782,"journal":{"name":"Sexual Medicine","volume":"13 5","pages":"qfaf080"},"PeriodicalIF":2.4,"publicationDate":"2025-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12526949/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145308431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and clinical correlates of Peyronie's disease in patients with Dupuytren's disease: a cross-sectional study from a tertiary andrology center.","authors":"Gökhan Çeker, Ertuğrul Arıkız, Akif Erbin, Hakan Anıl, Halil Lütfi Canat","doi":"10.1093/sexmed/qfaf083","DOIUrl":"10.1093/sexmed/qfaf083","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Dupuytren's disease (DD) and Peyronie's disease (PD) are fibroproliferative disorders that may share common pathophysiological mechanisms.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Aim: &lt;/strong&gt;To determine the prevalence of PD among male patients diagnosed with DD and to investigate its clinical and laboratory correlates.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;This cross-sectional observational study was conducted at a tertiary academic center and included 101 male patients diagnosed with DD. All participants underwent structured andrological evaluation and were classified into PD and non-PD groups. Clinical and laboratory parameters-including demographic, metabolic, sexual function, and inflammatory markers-were compared between the groups. Statistical analyses included descriptive statistics, Chi-square or Fisher's exact tests for categorical variables, and Mann-Whitney U tests for continuous variables. Binary logistic regression was performed to identify independent predictors of concomitant PD.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Outcomes: &lt;/strong&gt;The primary outcome was the prevalence of PD among patients with DD. Secondary outcomes included associations between PD and clinical/laboratory features.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;PD was significantly associated with bilateral Dupuytren's contracture (86.4% vs. 50.6%, &lt;i&gt;P&lt;/i&gt; = 0.003), diabetes mellitus (81.8% vs. 44.3%, &lt;i&gt;P&lt;/i&gt; = 0.003), lower high-density lipoprotein cholesterol (median 38 vs. 43 mg/dL, &lt;i&gt;P&lt;/i&gt; = 0.030), higher fasting glucose (median 146 vs. 104 mg/dL, &lt;i&gt;P&lt;/i&gt; = 0.018), and higher HbA1c (median 7.55% vs. 6.20%, &lt;i&gt;P&lt;/i&gt; = 0.005).Erectile function, assessed by the Erection Hardness Score, differed significantly between groups (median 3 in both; interquartile range: 2-3 in the PD group vs. 3-4 in the non-PD group, &lt;i&gt;P&lt;/i&gt; = 0.007) (no significant differences were observed in the 6-item International Index of Erectile Function and the Sexual Health Inventory for Men scores).In multivariate analysis, bilateral DD (OR = 17.80, &lt;i&gt;P&lt;/i&gt; = 0.020) and HbA1c (OR = 1.589, &lt;i&gt;P&lt;/i&gt; = 0.031) remained independently associated with PD. Other variables did not differ significantly between groups.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Clinical implications: &lt;/strong&gt;Male patients with DD-especially those with bilateral hand involvement or poor glycemic control-may warrant consideration for opportunistic urological evaluation to identify concomitant PD. However, further research is needed to determine the impact of early detection on patient outcomes.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Strengths and limitations: &lt;/strong&gt;This study is among the few to explore the prevalence and clinical correlates of PD in patients with DD, using a structured urological evaluation and comprehensive laboratory profiling. However, its cross-sectional design limits causal inference, and the single-center setting may affect the generalizability of the findings.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;PD is highly prevalent among patients with DD, especially those with bilater","PeriodicalId":21782,"journal":{"name":"Sexual Medicine","volume":"13 5","pages":"qfaf083"},"PeriodicalIF":2.4,"publicationDate":"2025-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12526938/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145308792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to: Anal sex practices and rectal erogenous zone maps among men and women of diverse sexual orientations: an anatomic-map based questionnaire study.","authors":"","doi":"10.1093/sexmed/qfaf090","DOIUrl":"10.1093/sexmed/qfaf090","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.1093/sexmed/qfaf037.].</p>","PeriodicalId":21782,"journal":{"name":"Sexual Medicine","volume":"13 5","pages":"qfaf090"},"PeriodicalIF":2.0,"publicationDate":"2025-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12518211/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145303296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differential efficacy of pelvic floor muscle training in primary versus acquired premature ejaculation: an 8-week comparative study using non-invasive biomechanical assessment.","authors":"Yinan Lyu, Jiawei Gong, Houdong He, Hongzhe Xu, Huiping Dong, Yue Duan","doi":"10.1093/sexmed/qfaf081","DOIUrl":"10.1093/sexmed/qfaf081","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Premature ejaculation (PE), including lifelong (LPE) and acquired (APE) subtypes, negatively affects men's sexual, psychological, and relational well-being.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Aim: &lt;/strong&gt;This study aimed to investigate pelvic floor muscle function differences between healthy individuals and premature ejaculation patients and evaluate the efficacy of pelvic floor muscle training in improving premature ejaculation subtype symptoms using an innovative assessment approach.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;In this 8-week prospective study, 199 men were enrolled (LPE, n = 66; APE, n = 83; healthy controls [HC], n = 50). PE participants received PFMT comprising PFM awareness, biofeedback-based strengthening, and integration into sexual activity. PFM function was measured with a perineometry/biofeedback device; anxiety and depression with 7-item Generalized Anxiety Disorder scale (GAD-7) and 9-item Patient Health Questionnaire (PHQ-9); and intravaginal ejaculatory latency time (IELT) by stopwatch.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Outcome: &lt;/strong&gt;The primary outcomes were improvements in pelvic floor muscle function, ejaculatory latency time, and premature ejaculation symptom severity.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;After 8 weeks of PFMT, significant improvements were observed in both groups. In the APE group, IELT increased from a median of 120 s to 180 s, and premature ejaculation diagnostic tool (PEDT) scores decreased by 2 points (&lt;i&gt;P&lt;/i&gt; &lt; 0.001). In the LPE group, IELT increased from 30 s to 60 s, and PEDT scores decreased by 1.5 points (&lt;i&gt;P&lt;/i&gt; &lt; 0.001). Reductions in PHQ-9 (APE: -3.0; LPE: -2.0) and GAD-7 (APE: -3.0; LPE: -1.0) scores were also observed, with APE showing greater overall benefits. No significant baseline differences were found in PFM strength; however, both groups showed post-training increases in maximum contraction pressure and sustained contraction average pressure (all &lt;i&gt;P&lt;/i&gt; &lt; 0.001).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Clinical implications: &lt;/strong&gt;Pelvic floor muscle training appears effective in addressing psychological and physical symptoms of premature ejaculation, particularly for acquired premature ejaculation.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Strengths and limitations: &lt;/strong&gt;This study is the first to use a non-invasive biomechanical approach to compare pelvic floor muscle function between healthy individuals and PE patients. It also uniquely examines how PFM training affects different PE subtypes, offering insights for more targeted treatment strategies. However, the research is limited by the absence of sham controls, which are necessary to distinguish placebo effects, and it also lacks long-term follow-up to assess enduring outcomes.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;Pelvic floor muscle training improves ejaculatory control and psychological outcomes in premature ejaculation patients, with greater efficacy observed in acquired premature ejaculation; further research is needed to explore long-term effects and underlying mechanisms.&lt;/p","PeriodicalId":21782,"journal":{"name":"Sexual Medicine","volume":"13 5","pages":"qfaf081"},"PeriodicalIF":2.4,"publicationDate":"2025-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12516947/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145293674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Yimusake ameliorates corporal endothelial dysfunction by down-regulating the NLRP3 inflammasome-mediated NF-κB signaling pathway and inhibiting oxidative stress.","authors":"Chengxia Yang, Rui Zhang, Bingbing Zhu, Lipan Niu, Wenfei Wang, Xiufang Jin, Yulian Liu, Fengxia Liu","doi":"10.1093/sexmed/qfaf079","DOIUrl":"10.1093/sexmed/qfaf079","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Yimusake, a traditional Uyghur medicine, can treat a variety of male diseases, but its effects and mechanisms on diabetes mellitus-induced erectile dysfunction (DMED) remain unclear.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Aim: &lt;/strong&gt;This study was designed to investigate the key cytokines and mechanisms by which Yimusake ameliorates corporal endothelial dysfunction in DMED rats.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;Firstly, normal rat penile corpus cavernosum endothelial cells (CCECs) were extracted and cultured &lt;i&gt;in vitro&lt;/i&gt;, and the injury model was established after stimulation with 30 mM glucose for 24 hours. Subsequently, the cells were cultured in Yimusake drug-containing serum for 24 hours, and Sh-NLRP3 lentivirus was transfected for 8 hours. Cells were collected for the subsequent experiments. Next, the DM model was established using streptozotocin (45 mg/kg) for 2 consecutive injections, and DMED rats were screened by apomorphine and mating test at weeks 2, 4, 6, and 8, and then, we intervened for a fortnight using Yimusake (Y) and NLRP3 inhibitor (MCC950) drugs, and the penile tissues were taken for the subsequent analyses.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Outcomes: &lt;/strong&gt;Our study demonstrates that Yimusake can downregulate the NLRP3-mediated NF-κB signalling pathway, inhibiting oxidative stress and mitigating the endothelial damage in corpus cavernosum endothelial cells.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;In the CCEC injury model established by 30 mM glucose, after incubation with Yimusake-containing drug serum and transfection with Sh-NLRP3 lentivirus, the expression of proteins and mRNAs related to the NF-κB signaling pathway mediated by NLRP3 was decreased, the expression of proteins related to oxidative stress was decreased, and the expression of proteins related to the endothelial function was increased. In DMED rats, after Yimusake and MCC950 interventions, the changes in pathway factors, oxidative stress levels, and endothelial function were consistent with the trends of &lt;i&gt;in vitro&lt;/i&gt; experiments.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Clinical implications: &lt;/strong&gt;Yimusake may ameliorate endothelial dysfunction in DMED by down-regulating the NLRP3 inflammasome-mediated NF-κB signaling pathway and inhibiting oxidative stress.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Strengths and limitations: &lt;/strong&gt;Although we revealed that Yimusake can facilitate the restoration of the erectile tissue by improving endothelial function through inhibiting inflammation and oxidative stress, the effect was more significant with the combination of drugs, and the exact mechanism of action needs to be further explored.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;These findings demonstrate that DM exacerbates oxidative stress and endothelial damage in the corpus cavernosum through activation of the NLRP3 inflammasome-mediated NF-κB pathway, whereas Yimusake can inhibit oxidative stress and mitigate endothelial damage by downregulating this pathway, thereby facilitating the restoration of erectile tissue in rats with","PeriodicalId":21782,"journal":{"name":"Sexual Medicine","volume":"13 5","pages":"qfaf079"},"PeriodicalIF":2.4,"publicationDate":"2025-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12516956/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145293653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Local surgical trauma in the penile tunica albuginea of the rat: a new animal model of Peyronie's disease.","authors":"Zitaiyu Li, Hongji Hu, Xiaoping Zheng, Biao Liu, Liangyu Zhao, Zhitao Han, Zihao Zhou, Jiarong Xu, Yinghao Yin, Yuxin Tang","doi":"10.1093/sexmed/qfaf082","DOIUrl":"10.1093/sexmed/qfaf082","url":null,"abstract":"<p><strong>Background: </strong>Peyronie's disease (PD) is a relatively common clinical disorder of the penis that causes curvature and erectile dysfunction. However, the pathophysiological processes of PD are not well understood in current animal models and there exists limited clinical treatment options, which significantly impedes translational research.</p><p><strong>Aim: </strong>This study aimed to develop a novel rat model of PD induced by local surgical tunica albuginea trauma and compare it with the TGF-β-induced model to elucidate the scientific soundness and feasibility of the local surgical tunica albuginea trauma-induced PD model.</p><p><strong>Methods: </strong>A total of 24 male standard deviation rats were randomly allocated into three groups: sham group, surgical trauma group, and TGF-β group. The sham group received a skin incision only, whereas the surgical trauma group and the TGF-β group underwent PD model establishment via microsurgical tunica albuginea trauma and TGF-β injection, respectively. Six weeks post-modeling, penile blood perfusion, degree of curvature and erectile function were quantified. Penile tissues were subsequently harvested for histological analysis and Western blotting was used to evaluate tunica albuginea fibrosis.</p><p><strong>Outcomes: </strong>PD model of surgical tunica albuginea trauma was successfully established and exhibited more pronounced fibrotic phenotypes in the penile tunica albuginea.</p><p><strong>Results: </strong>Compared with TGF-β-induced models, laser speckle imaging revealed significantly reduced penile blood perfusion in surgical trauma group, accompanied by more severe penile curvature with corresponding angular and curvature alterations. HE and Masson's trichrome staining demonstrated marked local thickening and significantly increased collagen deposition in the penile tunica albuginea of rats in the surgical trauma group. Sirius red staining revealed a marked increase in collagen I and collagen III content. Immunofluorescence staining and Western blot analysis revealed that the surgical trauma group exhibited more pronounced alterations in the expression levels of fibrosis-related markers (Fibronectin, α-SMA, Collagen I, and Collagen III) in penile tissue.</p><p><strong>Clinical implications: </strong>The rat model of tunica albuginea surgical trauma provides a promising option for preclinical PD research.</p><p><strong>Strengths and limitations: </strong>The tunica albuginea surgical trauma-induced PD model established in our study has been scientifically validated. However, the precise pathogenesis of the model requires further investigation.</p><p><strong>Conclusion: </strong>The tunica albuginea surgical trauma-induced PD model was successfully established and demonstrates a more pronounced fibrotic phenotype in the penile tunica albuginea, potentially better recapitulating the pathophysiological processes of PD.</p>","PeriodicalId":21782,"journal":{"name":"Sexual Medicine","volume":"13 5","pages":"qfaf082"},"PeriodicalIF":2.0,"publicationDate":"2025-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12516952/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145293697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Frequency of lab HIV and self-reported STI history and its predictors among a sexually compulsive clinical sample: a cross-sectional study.","authors":"Nisa Regina Bubola Lima, Isabelle Vera Vichr Nisida, Marco de Tubino Scanavino","doi":"10.1093/sexmed/qfaf077","DOIUrl":"10.1093/sexmed/qfaf077","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background and aims: &lt;/strong&gt;Individuals with compulsive sexual behavior (CSB) are at increased risk for sexually transmitted infections (STI) and Human Immunodeficiency Virus (HIV).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Aim: &lt;/strong&gt;To investigate the frequency of STIs and HIV in a CSB clinical sample and the associated predictors.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;A cross-sectional study was conducted between 2012 and 2021 in a specialized outpatient clinic at a large tertiary hospital in São Paulo, Brazil. We disclosed the study through noticeboards in the institution and advertisements on the official website and social media. Participants underwent a psychiatric interview to assess CSB and exclusion criteria. Individuals who sought treatment for difficulty in controlling sexual impulses and got confirmation of a CSB diagnosis were included. Those who did not were included as controls. Healthy volunteers who sought to participate as controls and did not confirm CSB diagnosis were also included. Comprehensive laboratory tests were requested. We investigated sexual compulsivity, impulsivity, patterns of CSB, condomless anal and vaginal sex and sex under the influence of alcohol/drugs, self-reported STI diagnoses or history, and screening tests. Logistic regression analysis was used.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Outcomes: &lt;/strong&gt;Laboratory results of HIV tests and self-reported STI diagnoses or history.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;A total of 275 participants (67.5%) met the criteria for CSB, and 132 (32.5%) were eligible as controls. The frequency of HIV in tested participants was 10.8% (n = 23) in the CSB group and 2.4% (n = 2) among controls. Regarding self-reported STI diagnoses or history, 43.9% of CSB outpatients and 17.8% of the control group reported it [χ&lt;sup&gt;2&lt;/sup&gt; &lt;sub&gt;(1)&lt;/sub&gt; = 25.58, &lt;i&gt;P&lt;/i&gt; &lt; .001]. The HIV-positive test was associated with self-identifying as gay or bisexual [OR 31.58, 95% CI 4.09-243.72, &lt;i&gt;P&lt;/i&gt; &lt; .05] and sex under the influence of drugs [OR 6.49, 95% CI 1.10-38.35] in the final multivariate analysis model, adjusted for other variables. Sexual compulsivity [OR 1.03, 95% CI 1.00-1.07, &lt;i&gt;P&lt;/i&gt; &lt; .05], excessive casual sex [OR 1.84, 95% CI 1.07-3.17, &lt;i&gt;P&lt;/i&gt; &lt; .05], and self-identifying as of African descent [OR 0.50, 95% CI 0.29-0.88, &lt;i&gt;P&lt;/i&gt; &lt; .05] behave as predictors of self-reported STI.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Clinical implications: &lt;/strong&gt;We suggest incorporating frequent and periodic screening tests for HIV/STI in the management protocols of CSB patients, considering the potential morbidity and social burden of STI.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Strengths and limitations: &lt;/strong&gt;To our knowledge, this is the first study investigating the frequency of HIV in a sexually compulsive clinical sample using laboratory tests, including women and participants of diverse sexual orientations. However, the prolonged data collection time was a limitation and many outpatient CSB participants commonly avoided taking exams and even left before this step. Beca","PeriodicalId":21782,"journal":{"name":"Sexual Medicine","volume":"13 5","pages":"qfaf077"},"PeriodicalIF":2.4,"publicationDate":"2025-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12496012/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145233582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Plasma metabolites mediate the causal relationship between gut microbiota and erectile dysfunction: insights from Mendelian randomization study.","authors":"Wei Wang, Bowen Tang, Sushun Yuan, Hongchen Luan, Tao Qi, Jun Chen","doi":"10.1093/sexmed/qfaf076","DOIUrl":"10.1093/sexmed/qfaf076","url":null,"abstract":"<p><strong>Background: </strong>While the relationship between gut microbiota and erectile dysfunction (ED) has been reported, the specific pathways involved remain unclear.</p><p><strong>Aim: </strong>This study aims to investigate the causal relationship between gut microbiota and ED, and to identify the potential role of plasma metabolites as mediators.</p><p><strong>Methods: </strong>Utilizing aggregated genome-wide association study (GWAS) data, a comprehensive two-sample Mendelian randomization (MR) analysis was performed involving 196 gut microbiota taxa, 1400 plasma metabolites and ED. Causal relationships between gut microbiota, plasma metabolites and ED were explored. In addition, mediation analysis was applied to identify the pathway from gut microbiota to ED mediated by plasma metabolites.</p><p><strong>Outcomes: </strong>This study reveals that plasma metabolites act as mediators regulating the influence of gut microbiota on ED.</p><p><strong>Results: </strong>MR analysis identified causal relationships between six gut microbial taxa and ED, with <i>Butyrivibrio</i> increasing the risk of ED, while <i>Alistipes, Prevotella 9, Dialister, Marvinbryantia</i>, and <i>LachnospiraceaeUCG010</i> exhibited protective effects. Additionally, 45 plasma metabolites demonstrated causal associations with ED. Finally, mediation analysis revealed four mediation relationships. Sensitivity analysis indicated no heterogeneity or pleiotropy in this study.</p><p><strong>Clinical implications: </strong>Modulating gut microbiota or targeting specific metabolites may offer new therapeutic approaches for ED, highlighting the potential for microbiome-based interventions.</p><p><strong>Strengths and limitations: </strong>The MR approach and large-scale GWAS data provide robust causal evidence, but the findings are limited by their focus on European populations and lack of experimental validation. Further studies are needed to confirm these mechanisms in diverse cohorts and functional models.</p><p><strong>Conclusion: </strong>This study establishes a causal link between gut microbiota, plasma metabolites, and ED, identifying specific microbial taxa and metabolites as key contributors to ED risk. The mediating role of plasma metabolites highlights potential therapeutic strategies, such as probiotics or dietary interventions targeting harmful metabolites.</p>","PeriodicalId":21782,"journal":{"name":"Sexual Medicine","volume":"13 5","pages":"qfaf076"},"PeriodicalIF":2.4,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12481684/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145207519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Labia majora lifting technique with polydioxanone threads.","authors":"Savas O Aglamis, Selver K Akkaya, Elif O Sahin, Hanifi Sahin","doi":"10.1093/sexmed/qfaf064","DOIUrl":"10.1093/sexmed/qfaf064","url":null,"abstract":"<p><strong>Background: </strong>Polydioxanone (PDO) thread is a synthetic absorbable surgical suture used for rejuvenation and lifting.</p><p><strong>Aim: </strong>The aim of this study is to use PDO threads for rejuvenation and enlargement effect in patients with labium majus hypotrophy.</p><p><strong>Methods: </strong>Twenty-one patients with labia majora hypotrophy were included in the study. Conventionally, surgery, fat filling or hyaluronic acid filling is used for labia majora rejuvenation. In this study, a different technique, the PDO thread suspension technique, was applied. For PDO thread, Hyundae Meditech Co.Ltd's Secret Line Up product containing 50 mm screw thread with 30 G-38 mm needle tip was used. It was planned to use 10 PDO threads for right and left labia majora. After a total of 20 needles were inserted, the needles were removed one by one and the PDO threads remained in the subcutaneous superficial layer and the procedure was terminated 5 min later. Preoperative and postoperative the Female Genital Self-Image Scale (FGSIS) scores of the patients were compared.</p><p><strong>Outcomes: </strong>The overall FGSIS total score demonstrated a significant increase following the intervention.</p><p><strong>Results: </strong>The FGSIS total mean score in the preoperative period was increased in the postoperative period. This difference was statistically significant. Moreover, the mean score calculated for each parameter of FGSIS in the preoperative period increased significantly in the postoperative period.</p><p><strong>Clinical implications: </strong>These findings indicate a favorable safety profile for the use of PDO threads in this clinical context.</p><p><strong>Strengths and limitations: </strong>The strength of the study is to introduce a minimally invasive and effective method for labia majora lifting, on the other hand, the small number of patients in the study, limitation of the study.</p><p><strong>Conclusion: </strong>We would like to point out that in this study, we evaluated labium majus rejuvenation from the same perspective, based on the shaping and enlargement of genital appearance and its positive effect on self-confidence and increase in sexual functions. Unlike many labium majus rejuvenation procedures, this less invasive procedure has achieved similar results. In this context, it is a preferable alternative to surgery.</p>","PeriodicalId":21782,"journal":{"name":"Sexual Medicine","volume":"13 5","pages":"qfaf064"},"PeriodicalIF":2.4,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12481682/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145207421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The use of tirzepatide to successfully treat persistent genital arousal disorder/genitopelvic dysesthesia: a case report.","authors":"Eliza Burr, Maya Roytman, Évéline Poirier, Marta Kolbuszewska, James G Pfaus, Barry R Komisaruk, Irwin Goldstein, Rachel Rubin","doi":"10.1093/sexmed/qfaf073","DOIUrl":"10.1093/sexmed/qfaf073","url":null,"abstract":"<p><strong>Introduction: </strong>Persistent genital arousal disorder/genitopelvic dysesthesia (PGAD/GPD) is associated with poor quality of life. Due to social stigma and its heterogeneous nature, many patients suffer without treatment.</p><p><strong>Aims: </strong>This case presents the first example of the successful use of a glucagon-like peptide 1 and glucose-dependent insulinotropic polypeptide receptor agonist (GLP1/GIP RA) medication for the treatment of PGAD/GPD.</p><p><strong>Methods: </strong>The patient was identified by the Sexual Medicine Research Team, retained as a patient at a sexual medicine clinic, and interviewed for the purposes of this case report.</p><p><strong>Results: </strong>This case presents a 44-year-old woman with a lifelong history of PGAD/GPD symptoms that caused extreme distress and depression who experienced 95% resolution of her symptoms within 2 days of starting tirzepatide, a GLP1/GIPRA medication, for weight loss.</p><p><strong>Conclusion: </strong>Increasing benefits of GLP1/GIPRAs are being uncovered, and further studies must investigate the potential for these medications to be used in patients with PGAD/GPD. This study also provides a potential mechanism for decreased arousal resulting from GLP1/GIP receptor activation in attention/reward pathways in the brain.</p>","PeriodicalId":21782,"journal":{"name":"Sexual Medicine","volume":"13 4","pages":"qfaf073"},"PeriodicalIF":2.0,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12459093/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145150796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}