Sexual Medicine最新文献

{"title":"Letter to the Editor on \"Association of total testosterone levels with cardiometabolic diseases in men with erectile dysfunction\".","authors":"Scott Selinger, Gregory R Thoreson","doi":"10.1093/sexmed/qfaf020","DOIUrl":"10.1093/sexmed/qfaf020","url":null,"abstract":"","PeriodicalId":21782,"journal":{"name":"Sexual Medicine","volume":"13 2","pages":"qfaf020"},"PeriodicalIF":2.6,"publicationDate":"2025-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11972624/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143796354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to Letter to the Editor on \"The associations among platelet count, mean platelet volume, and erectile dysfunction: an observational and Mendelian randomization study\".","authors":"Jingxuan Peng, Jinshun An, Yuxing Chen, Jun Zhou, Boyu Xiang","doi":"10.1093/sexmed/qfaf016","DOIUrl":"10.1093/sexmed/qfaf016","url":null,"abstract":"","PeriodicalId":21782,"journal":{"name":"Sexual Medicine","volume":"13 2","pages":"qfaf016"},"PeriodicalIF":2.6,"publicationDate":"2025-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11972656/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143796446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the Editor on \"The associations among platelet count, mean platelet volume, and erectile dysfunction: an observational and Mendelian randomization study\".","authors":"Yuekun Fang, Shengyi Chen, Chenxiao Huang, Bin Cheng","doi":"10.1093/sexmed/qfaf015","DOIUrl":"10.1093/sexmed/qfaf015","url":null,"abstract":"","PeriodicalId":21782,"journal":{"name":"Sexual Medicine","volume":"13 2","pages":"qfaf015"},"PeriodicalIF":2.6,"publicationDate":"2025-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11972627/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143796439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Menopause is associated with a decrease in sexual function among women with endometriosis.","authors":"Alexandre Vallée, Pierre-François Ceccaldi, Jean-Marc Ayoubi","doi":"10.1093/sexmed/qfaf019","DOIUrl":"10.1093/sexmed/qfaf019","url":null,"abstract":"<p><strong>Background: </strong>Menopause-related endocrinological shifts are linked to sexual dysfunction, and women with endometriosis exhibit lower Female Sexual Function Index (FSFI) scores, indicating impaired sexual well-being.</p><p><strong>Aim: </strong>To assess the impact of menopause on sexual function in women with endometriosis.</p><p><strong>Methods: </strong>An anonymous online survey was conducted among 1586 French women diagnosed with endometriosis. The FSFI questionnaire was used to evaluate sexual function, and menopause was defined as ≥12 months of amenorrhea. Multivariable logistic regression was performed to assess the relationship between FSFI scores and menopause status, adjusting for tobacco use, education, number of symptoms, and history of surgery. Logworth analyses were used to determine the strongest components of FSFI associated with menopause.</p><p><strong>Outcomes: </strong>The primary outcome was the FSFI total score and its six domains (desire, arousal, vaginal lubrication, orgasm, satisfaction, and dyspareunia) in menopausal and non-menopausal women with endometriosis.</p><p><strong>Results: </strong>Menopausal women had significantly lower FSFI scores (15.3 vs. 16.9, <i>P</i> = 0.021). After adjustment, FSFI remained significantly lower (<i>P</i> = 0.026) in menopausal women but did not reach the established FSFI cutoff for sexual dysfunction (<i>P</i> = 0.451). Stratified analysis by age showed a steep decline in FSFI between 46 and 50 years, partial improvement at 51-55 years, and further decline after 55 years, particularly in arousal, orgasm, dyspareunia, and satisfaction. Arousal (logworth = 4.53, <i>P</i> < 0.001) was the most affected domain, followed by satisfaction (logworth = 1.81, <i>P</i> = 0.015).</p><p><strong>Clinical implications: </strong>Arousal appears to be the key determinant of sexual function decline in menopausal women with endometriosis, highlighting the need for targeted interventions such as hormone therapy, pain management, and sexual counseling.</p><p><strong>Strengths & limitations: </strong>The study benefits from a large sample size and validated FSFI assessment but is limited by selection bias from online recruitment, self-reported diagnosis of endometriosis, and lack of hormonal status confirmation. The cross-sectional design prevents causal inferences.</p><p><strong>Conclusion: </strong>Menopause is associated with a decline in FSFI scores among women with endometriosis, with arousal being the most affected domain, underscoring the need for further research on personalized management strategies for sexual dysfunction in this population.</p>","PeriodicalId":21782,"journal":{"name":"Sexual Medicine","volume":"13 2","pages":"qfaf019"},"PeriodicalIF":2.6,"publicationDate":"2025-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11972087/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143796443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Icariin inhibits hyperglycemia-induced cell death in penile cavernous tissue and improves erectile function in type 1 diabetic rats.","authors":"Haowei Yang, Wenju Xiong, Jun Jiang, Rui Jiang","doi":"10.1093/sexmed/qfaf017","DOIUrl":"10.1093/sexmed/qfaf017","url":null,"abstract":"<p><strong>Background: </strong>Hyperglycemia can cause endothelial cell (EC) and smooth muscle cell (SMC) death in the penile cavernous tissue of rats and lead to erectile dysfunction (ED).</p><p><strong>Objectives: </strong>To investigate the proportions of apoptotic, pyroptotic, and ferroptotic cells among ECs and SMCs in the penile cavernous tissue of type 1 diabetic (T1DM) rats and the mechanism by which icariin (ICA) improves the erectile function of T1DM rats.</p><p><strong>Methods: </strong>A total of 24 9-week-old Sprague-Dawley (SD) rats were randomly divided into 4 groups (<i>n</i> = 6): control group, control + ICA group, diabetic mellitus (DM) group, and DM + ICA group. T1DM rats were generated via the intraperitoneal injection of STZ (45 mg/kg). After 8 weeks, the rats in the control + ICA group and the DM + ICA group were administered ICA (10 mg/kg/d) by gavage for 4 weeks. ROS, MDA, SOD, GSH, SM/C, and NO levels, and GPX4, ACSL4, caspase-1, GSDMD, caspase-3, CD31, α-SMA, and p-eNOS/eNOS expression in penile cavernous tissue and the ICPmax/MAP of 21-week-old rats were detected.</p><p><strong>Results: </strong>The percentage of pyroptotic SMCs in penile cavernosum was no statistically significant difference among these groups. Vs control group, the percentages of apoptotic (20.70% ± 1.60%), pyroptotic (21.02% ± 1.97%), and ferroptotic (9.01% ± 2.00%) ECs and the percentages of apoptotic (15.47% ± 1.36%) and ferroptotic (26.33% ± 3.11%) SMCs in the penile cavernous tissue of the DM group were significantly greater. Vs DM group, the percentages of apoptotic (9.13% ± 1.28%), pyroptotic (13.22 ± 1.26%), and ferroptotic (4.01% ± 0.86%) ECs and the percentages of apoptotic (11.60% ± 1.91%) and ferroptotic (12.71% ± 2.92%) SMCs of the DM + ICA group were significantly lower. Vs the DM group, the levels of caspase-1, GSDMD, ACSL4, and ROS were significantly lower in the penile cavernous tissue of the DM + ICA group. Meanwhile, the levels of GPX4 and maximum intracavernous pressure/mean arterial pressure (ICPmax/MAP) were significantly higher.</p><p><strong>Clinical implications: </strong>The combined inhibition of apoptosis, pyroptosis, and ferroptosis in penile cavernous tissue by ICA provides a theoretical basis for the clinical development of multi-target drugs for the treatment of type 1 diabetes-induced ED.</p><p><strong>Strengths and limitations: </strong>Further experiments are required to clarify whether other types of cell death are involved in the loss of ECs and SMCs in the penile cavernous tissue of T1DM rats.</p><p><strong>Conclusion: </strong>Inhibiting oxidative stress and thereby inhibiting apoptosis, pyroptosis, and ferroptosis in ECs and SMCs of penile cavernous tissue constitute one of the mechanisms through which ICA improves erectile function in T1DM rats.</p>","PeriodicalId":21782,"journal":{"name":"Sexual Medicine","volume":"13 1","pages":"qfaf017"},"PeriodicalIF":2.6,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11950537/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143754417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the editor on \"No bidirectional association between serum 25-hydroxyvitamin D and erectile dysfunction: Mendelian randomization and genetic association studies\".","authors":"Xingcheng Zhu, Junxian Zhao, Mengjun Tang, Shi Fu, Jieming Zuo, Junhao Chen","doi":"10.1093/sexmed/qfaf018","DOIUrl":"10.1093/sexmed/qfaf018","url":null,"abstract":"","PeriodicalId":21782,"journal":{"name":"Sexual Medicine","volume":"13 1","pages":"qfaf018"},"PeriodicalIF":2.6,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11950526/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143754420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mendelian randomization analyses reveal causal relationships between chronic psychological stress and risk of erectile dysfunction.","authors":"Wei Wang, Bowen Tang, Zhansen Huang, Sushun Yuan, Hongchen Luan, Hengjun Xiao, Jun Chen","doi":"10.1093/sexmed/qfaf014","DOIUrl":"10.1093/sexmed/qfaf014","url":null,"abstract":"<p><strong>Background: </strong>The association between psychological stress and erectile dysfunction (ED) has been reported, but the causality of different types of stressors on ED is poorly understood.</p><p><strong>Aim: </strong>This study aims to investigate the causal relationship between various forms of psychological stress and ED through Mendelian randomization (MR).</p><p><strong>Methods: </strong>Several genome-wide association study (GWAS) datasets related to chronic psychological stress were used in this study for the identification of instrumental variables. Concurrently, a genome-wide association studies database provided the ED outcome data containing 6175 ED patients and 217 630 controls. The MR-Egger, inverse variance weighting (IVW), weighted median, and maximum likelihood methods were applied to conduct the MR study and IVW was taken as the primary criterion.</p><p><strong>Outcomes: </strong>Mendelian randomization analyses revealed that financial difficulties were associated with a heightened risk of ED, whereas the absence of stressors was linked to a decreased risk.</p><p><strong>Results: </strong>Among the various types of psychological stressors analyzed, financial difficulties were found to significantly increase the risk of ED (<i>P</i> = .022, OR = 4.343, 95%CI = 1.240-15.216). In contrast, other stressors did not significantly elevate the risk of ED. Furthermore, the absence of these stressors was associated with a reduced risk of ED (<i>P</i> = .009, OR = 0.211, 95% CI = 0.066-0.681).</p><p><strong>Clinical implications: </strong>This study emphasizes the enormous impact of psychological stress, especially financial hardship, in increasing the risk of ED.</p><p><strong>Strengths and limitations: </strong>This study is the first to employ MR analysis to investigate the causal relationship between various stressors and ED. However, this study did not consider the influence of non-genetic factors such as living environment and lifestyles.</p><p><strong>Conclusion: </strong>Psychological stress, particularly financial difficulties, can increase the risk of ED, while the absence of such stressors appears to be protective. Consequently, it is imperative to enhance medical education and awareness among economically disadvantaged populations and to address the detrimental effects of adverse lifestyles.</p>","PeriodicalId":21782,"journal":{"name":"Sexual Medicine","volume":"13 1","pages":"qfaf014"},"PeriodicalIF":2.6,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11937817/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143721371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between C-reactive protein-triglyceride glucose index and testosterone levels among adult men: analyses of NHANES 2015-2016 data.","authors":"Bo Zhang, Yi Gu, Yiming Chen, Wei Xia, Naiyuan Shao, Qianfeng Zhuang, Xingliang Feng","doi":"10.1093/sexmed/qfaf012","DOIUrl":"10.1093/sexmed/qfaf012","url":null,"abstract":"<p><strong>Background: </strong>The C-reactive protein-triglyceride glucose index (CTI) is a recently introduced index designed to simultaneously assess inflammation (via CRP) and insulin resistance (via the triglyceride-glucose index, TyG), both of which are recognized risk factors for declining testosterone levels in men.</p><p><strong>Aim: </strong>This study investigates the association between CTI and low testosterone levels in American adult men, aiming to evaluate CTI as a predictor of low testosterone level.</p><p><strong>Methods: </strong>Data from the 2015-2016 NHANES were used in this cross-sectional study, including men aged 20 and older. Multivariate linear and logistic regression models were employed to analyze the relationship between CTI, total testosterone levels, and the risk of low testosterone level. Receiver operating characteristic (ROC) curves were generated to assess the predictive performance of CTI for low testosterone level.</p><p><strong>Outcomes: </strong>The primary outcome was testosterone levels, with low testosterone level defined as a serum testosterone level below 300 ng/dL in adult men.</p><p><strong>Results: </strong>Among 878 participants, 189 had low testosterone level. The mean CTI was significantly higher in the low testosterone level group (9.39 ± 0.09) compared to the non- low testosterone level group (8.62 ± 0.05; <i>P</i> < .0001). After adjusting for covariates, higher CTI was significantly associated with lower total testosterone levels (β = -44.6, 95% CI: -66.34, -22.87, <i>P</i> < .001) and increased low testosterone level risk (OR = 1.84, 95% CI: 1.31, 2.57, <i>P</i> = .002). ROC analysis showed that CTI (AUC = 0.7357, 95% CI: 0.6975, 0.7739) outperformed TyG and VAI in predicting low testosterone level, highlighting its potential clinical value in assessing low testosterone status.</p><p><strong>Clinical implications: </strong>Timely monitoring of testosterone levels in individuals with elevated CTI is clinically significant. Additionally, for those with TD, regular assessment of CTI may help in preventing future cardiovascular complications.</p><p><strong>Strengths and limitations: </strong>This study is the first to explore the relationship between CTI and low testosterone using a large sample from the NHANES database. However, due to the cross-sectional design, causal inference regarding CTI and low testosterone level cannot be drawn.</p><p><strong>Conclusions: </strong>CTI appears to be a more effective predictor of low testosterone level than TyG, CRP, or VAI, suggesting its usefulness as a simple, low-cost indicator for early TD risk assessment. Further research is needed to verify its clinical applicability across diverse populations.</p>","PeriodicalId":21782,"journal":{"name":"Sexual Medicine","volume":"13 1","pages":"qfaf012"},"PeriodicalIF":2.6,"publicationDate":"2025-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11890278/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143586830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sexual satisfaction and function (SatisFunction) survey post-vaginoplasty for transgender and gender diverse individuals: preliminary development and content validity for future clinical use.","authors":"Amine Sahmoud, Rebekah Russell, Erika Kelley, Elad Fraiman, Carly Goldblatt, Matthew Loria, Kirtishri Mishra, Shubham Gupta, Rachel Pope","doi":"10.1093/sexmed/qfaf011","DOIUrl":"10.1093/sexmed/qfaf011","url":null,"abstract":"<p><strong>Background: </strong>Transgender and gender diverse individuals (TGDIs) are people whose gender identity is not in line with their sex assigned at birth, but current surveys used for cisgender patients addressing sexual satisfaction and function (SFS) do not fit the needs of this unique population.</p><p><strong>Aim: </strong>The authors of this project sought to create and validate a new comprehensive survey in North American English that differs from the current options for TGDI post-vaginoplasty.</p><p><strong>Materials and methods: </strong>Using the current literature on SFS as a foundation, a 26-item survey was created and distributed to 16 TGDI at least 3 months post-vaginoplasty. Feedback and review for content validity took place in the forms of interviews with the 16 TGDI, an expert panel, and the creation of a community advisory board.</p><p><strong>Outcomes: </strong>Feedback was incorporated to transform the original 26-item questionnaire into a 32-question survey with eight domains, named the SatisFunction Survey Post-Vaginoplasty, which represents the preliminary development and content validity of the survey, with its clinical use not recommended until further validation steps are completed.</p><p><strong>Results: </strong>Feedback focused on improving the clarity of questions to address sexual vs non-sexual behaviors, providing definitions of terms in the question stems for improved user understanding, including more questions on specific anatomic locations, addressing gender dysphoria as it relates to genital self-image, specifying type of vaginoplasty and only including questions relevant to those with or without a vaginal canal.</p><p><strong>Clinical implications: </strong>The authors foresee clinical use of the survey for recurrent assessment in the postoperative period as well as post-revision.</p><p><strong>Strength and limitations: </strong>Community-based research is essential in developing an assessment tool tailored to the unique needs of a specific population. This study presents the findings of preliminary content validation but requires further validation before clinical use, and is limited by a small sample size from a single-site institution.</p><p><strong>Conclusion: </strong>Future directions involve completing the validation process for the survey with distribution to a larger TGDI population with other validated surveys with a subsequent cohort interview to address construct and divergent validity as well as reliability.</p>","PeriodicalId":21782,"journal":{"name":"Sexual Medicine","volume":"13 1","pages":"qfaf011"},"PeriodicalIF":2.6,"publicationDate":"2025-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11890106/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143586833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unveiling consumer interest and regional disparities: comparative analysis of online search trends for penile aesthetic procedures.","authors":"Elia Abou Chawareb, Jasmin Banton, Muhammed A M Hammad, Supanut Lumbiganon, Babak Azad, Jake Miller, Faysal A Yafi","doi":"10.1093/sexmed/qfaf013","DOIUrl":"10.1093/sexmed/qfaf013","url":null,"abstract":"<p><strong>Background: </strong>Aesthetic procedures for penile enhancement, such as the Penuma silicone sleeve implant, have gained increasing attention for addressing concerns like perceived size, buried or retractile penis, and mild curvature.</p><p><strong>Aim: </strong>To assess the online search interest over time for penile enhancement modalities, analyze the trends, and explore any regional disparities in search patterns.</p><p><strong>Methods: </strong>Google Trends data from June 18, 2018, to June 11, 2023, were utilized to analyze search interest for Penuma, penile implant, penile girth, Hyaluronic acid (HLA) injection, and penis injection. The results were compared to the trend data for Penuma from 2004 to 2023. Trendlines were generated to assess the changes in search interest over time and determine if they followed a random or polynomial trend. The highest search interest locations were identified for each term, and the corresponding regional gross domestic product values were collected.</p><p><strong>Outcomes: </strong>Search interest was assessed in terms of volume, temporal trends, and regional disparities.</p><p><strong>Clinical implications: </strong>Understanding regional and temporal search patterns for penile enhancement can guide healthcare professionals and policymakers in developing targeted educational initiatives and allocating resources to meet patient needs.</p><p><strong>Strengths and limitations: </strong>The use of Google Trends provides a comprehensive and real-time assessment of public interest over a broad timeframe and geographic range. However, search interest data may not fully capture actual patient behaviors or clinical demand, and the analysis relies on assumptions about search terms accurately reflecting consumer intent.</p><p><strong>Results: </strong>Penuma initially garnered interest upon its introduction in 2004 but experienced a decline until around March 2021. Comparing Penuma with other terms, general searches for penile implant and penile girth exhibited significantly higher interest than Penuma. The trendlines indicated increasing search interest for penile implant and HLA injection, while Penuma demonstrated a declining trend. In terms of regional disparities, the highest search interest for Penuma was observed in San Antonio, TX, while penile girth searches were highest in Oklahoma City, OK. Penile implant searches were prominent in Mobile, AL, and Birmingham, AL. Notably, HLA injection searches peaked in New York, NY, and penis injection searches were most prevalent in Los Angeles, CA.</p><p><strong>Conclusion: </strong>This study reveals that online interest in Penuma lags other penile enhancement terms, with notable regional disparities in search patterns. These findings underscore the need for further research to understand the factors influencing these trends and to help healthcare professionals tailor educational efforts and resources to diverse consumer needs.</p>","PeriodicalId":21782,"journal":{"name":"Sexual Medicine","volume":"13 1","pages":"qfaf013"},"PeriodicalIF":2.6,"publicationDate":"2025-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11890111/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143586811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}