Sexual Medicine最新文献

{"title":"Safety profile and signal detection of tadalafil: a real-world analysis based on the Food and Drug adverse event reporting system.","authors":"Jie Li, Kecheng Li, Shihuang Yang, Yaxing Chen, Peixuan Ren, Guohe Deng, Lixing Lei, Qilong Ma, Haodong Yang, Longsheng Deng","doi":"10.1093/sexmed/qfag014","DOIUrl":"10.1093/sexmed/qfag014","url":null,"abstract":"<p><strong>Background: </strong>Tadalafil, a phosphodiesterase type 5 inhibitor, is widely used for erectile dysfunction and benign prostatic hyperplasia. Although generally well tolerated, concerns have emerged regarding uncommon but potentially clinically relevant adverse event (AE) reports and safety signals, particularly involving ocular, auditory, and cardiovascular systems.</p><p><strong>Aim: </strong>To characterize the post-marketing safety profile of tadalafil and identify potential safety signals using a real-world pharmacovigilance database.</p><p><strong>Methods: </strong>All AE reports with tadalafil as the primary suspected drug were retrieved from the FDA Adverse Event Reporting System (FAERS) from Q1 2004 to Q1 2024. After data deduplication and Medical Dictionary for Regulatory Activities (MedDRA, version 26.0) recoding, descriptive analyses were conducted to summarize demographic characteristics and AE distributions. Disproportionality analyses-including reporting odds ratio, proportional reporting ratio, Bayesian confidence propagation neural network, and empirical Bayes geometric mean-were applied to detect safety signals at system organ class (SOC) and preferred term (PT) levels.</p><p><strong>Outcomes: </strong>Primary outcomes included frequencies of reported AEs and identification of statistically significant signals across multiple signal-detection algorithms.</p><p><strong>Results: </strong>Among 85 927 reports, 9304 identified tadalafil as the primary suspect drug. Reported AEs involving tadalafil spanned 23 SOCs. Using 4 signal detection algorithms, 135 PTs were found to show statistically significant disproportionality. In addition, several potential safety signals not listed in the current drug labeling-such as retinal hemorrhage, elevated intraocular pressure, and ejaculatory dysfunction-were detected.</p><p><strong>Clinical significance: </strong>The identified signals highlight the importance of clinical vigilance, particularly in patients with potential vascular or sensory risk factors, and these findings contribute to raising clinical awareness and will guide future pharmacological epidemiological studies.</p><p><strong>Strengths and limitations: </strong>This study provides the most comprehensive real-world safety evaluation of tadalafil using FAERS up to 2024, employing 4 complementary algorithms to improve signal robustness. However, intrinsic limitations of spontaneous reporting-such as under-reporting, reporting bias, incomplete information, and inability to infer causality-necessitate cautious interpretation. Confounding by comorbidities and co-medications cannot be fully excluded.</p><p><strong>Conclusion: </strong>This systematic pharmacovigilance analysis characterizes the post-marketing safety signal spectrum of tadalafil and identifies several potential safety signals that warrant further investigation, and these findings are informative and may serve as a reference for future controlled studies and p","PeriodicalId":21782,"journal":{"name":"Sexual Medicine","volume":"14 2","pages":"qfag014"},"PeriodicalIF":2.0,"publicationDate":"2026-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13025081/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147575240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sarcopenia-related traits and erectile dysfunction: a bi-directional Mendelian randomization study.","authors":"Xu Jianxin, Wu Wensong, Fang Dengpan, Wang Yiwei, Chen Fangmin","doi":"10.1093/sexmed/qfag010","DOIUrl":"10.1093/sexmed/qfag010","url":null,"abstract":"<p><strong>Background: </strong>Erectile dysfunction (ED) and sarcopenia share many risk factors, but the causal direction of their association remains unclear.</p><p><strong>Aim: </strong>To investigate the potential causal relationship between sarcopenia-related traits and ED using genetic data.</p><p><strong>Methods: </strong>We conducted a bi-directional 2-sample Mendelian randomization (MR) analysis to evaluate the potential causal relationship between sarcopenia-related traits (hand grip strength, appendicular lean mass, and walking pace) and ED. We selected the inverse variance weighted (IVW) method as the main method to assess the causal effect, and we use Cochrane's Q tests derived from the IVW and MR-Egger method to evaluate the heterogeneity. To investigate horizontal pleiotropy, the study employed MR-Egger and MR-PRESSO methods. Leave-one-out analysis was conducted to assess the influence of individual genetic loci on the outcomes.</p><p><strong>Outcomes: </strong>Specific sarcopenia-related functional traits might increase the risk of ED, while reverse causality was not observed.</p><p><strong>Results: </strong>When considering sarcopenia-related characteristics as exposure factors, we found a positive causal relationship between appendicular lean mass and ED (OR = 1.097, CI = 1.009-1.194, <i>P</i> = .029) and a negative causal relationship between walking pace and ED (OR = 0.325, CI = 0.172-0.613, <i>P</i> = .00052). Hand grip strength showed no causal relationship with ED. Reverse MR results indicated that ED as an exposure factor did not have a causal relationship with sarcopenia-related characteristics. The MR-Egger intercept indicated no evidence of horizontal pleiotropy (<i>P</i> > .05). Cochran's Q test showed no significant heterogeneity (<i>P</i> > .05). Leave-one-out analysis revealed that excluding any single SNP did not significantly change the overall error lines, confirming the reliability of our conclusions.</p><p><strong>Clinical implications: </strong>Interventions aimed at improving overall physical function and fitness, particularly addressing a slow walking pace, may help reduce the risk of ED.</p><p><strong>Strengths and limitations: </strong>Key strengths include the MR design minimizing confounding and reverse causation, and comprehensive sensitivity analyses. The main limitation is that our study only contains samples of European descent.</p><p><strong>Conclusion: </strong>Specific sarcopenia-related functional traits, particularly a slower walking pace, may play a causal role in ED. These findings highlight the importance of overall physical function and fitness in ED risk, although further studies are needed to clarify the specific role of muscle mass.</p>","PeriodicalId":21782,"journal":{"name":"Sexual Medicine","volume":"14 2","pages":"qfag010"},"PeriodicalIF":2.0,"publicationDate":"2026-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13025071/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147575178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From sedation to stimulation: anecdotal case reports of enhanced sexual arousal in men and women taking diphenhydramine hydrochloride.","authors":"Melitzsa Pascale Regis, James G Pfaus","doi":"10.1093/sexmed/qfag011","DOIUrl":"10.1093/sexmed/qfag011","url":null,"abstract":"<p><strong>Introduction: </strong>Unexpected enhancement of sexual arousal, desire, and orgasm following diphenhydramine (DPH) ingestion has emerged in anecdotal reports across online platforms.</p><p><strong>Aims: </strong>To examine whether there are common effects of DPH on the sexual responses of women and men who respond to DPH with excitation rather than sedation.</p><p><strong>Methods: </strong>Qualitative case data were gathered from surveys of men and women on a DPH Reddit site to examine the consistency, intensity, and subjective nature of DPH effects on sexual arousal, desire, and orgasm.</p><p><strong>Results: </strong>Participants described enhanced sexual arousal, orgasm, increased stimulation sensitivity, and profound emotional release from DPH. Some found the effects stronger than those of prescription medications for sexual arousal disorders.</p><p><strong>Conclusion: </strong>These observations suggest a paradoxical pharmacological action of DPH, potentially involving dopaminergic and/or histaminergic pathways. While DPH itself is not a recognized therapeutic agent for the treatment of sexual dysfunctions, these unexpected effects may point toward a novel neurochemical mechanism of sexual excitation in some individuals that warrants further investigation.</p>","PeriodicalId":21782,"journal":{"name":"Sexual Medicine","volume":"14 2","pages":"qfag011"},"PeriodicalIF":2.0,"publicationDate":"2026-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13006966/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147514754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Using artificial intelligence to predict sexual health outcomes in endometriosis: a decision tree model algorithm.","authors":"Alexandre Vallée, Anis Feki, Jean-Marc Ayoubi","doi":"10.1093/sexmed/qfag013","DOIUrl":"10.1093/sexmed/qfag013","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Endometriosis profoundly impairs sexual function through complex interactions between pain, hormonal disturbances, psychological distress, and sociodemographic factors.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Aim: &lt;/strong&gt;To develop and validate a decision tree-based model identifying key predictors of sexual dysfunction in women with endometriosis.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;We conducted a cross-sectional online survey among 1586 women with endometriosis recruited through social media in France between November 2023 and January 2024. Participants completed sociodemographic and clinical questionnaires and the Female Sexual Function Index (FSFI), with sexual dysfunction defined as FSFI &lt; 26.55. The predictors included pain characteristics, menstrual symptoms, digestive symptoms, infertility, BMI, lifestyle factors, and treatment history. A classification and regression tree model was trained on 70% of the sample and validated on the remaining 30%. Model performance was assessed using area under the receiver operating characteristic curve (AUC), sensitivity, and specificity. Subgroups at high or low risk of sexual dysfunction were identified through terminal nodes (rules) of the decision tree.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Outcomes: &lt;/strong&gt;The primary outcome was classification into sexual dysfunction versus normal sexual function.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;Of the 1586 respondents, 1358 (86%) met the criteria for sexual dysfunction. The decision tree demonstrated strong discrimination in the training dataset (AUC = 0.96; sensitivity = 98%; specificity = 82%) and acceptable performance in the validation dataset (AUC = 0.79; sensitivity = 72%; specificity = 77%). Chronic pelvic pain, dyspareunia, worsening pain over time, heavy menstrual bleeding, infertility, BMI, digestive symptoms, education level, and treatment history were identified as major determinants. Several terminal nodes showed a 100% probability of sexual dysfunction, most notably women with severe menstrual cramps, heavy menstrual bleeding, no treatment, normal weight or obesity, infertility, or pronounced digestive symptoms. Conversely, women with no dyspareunia, no urinary or bowel pain, high education, and overweight exhibited a 0% probability of dysfunction.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Clinical implications: &lt;/strong&gt;AI-driven decision trees can support early identification of high-risk profiles and guide individualized management strategies to improve sexual health in women with endometriosis.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Strengths and limitations: &lt;/strong&gt;Strengths include a large sample, comprehensive symptom profiling, and transparent model interpretability. Limitations include reliance on self-reported diagnosis, potential selection bias inherent to online recruitment, lack of geographic and clinical verification data, and the cross-sectional nature of the analysis, preventing causal inference.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;A decision tree-based model accurately identified key predictors of sexu","PeriodicalId":21782,"journal":{"name":"Sexual Medicine","volume":"14 2","pages":"qfag013"},"PeriodicalIF":2.0,"publicationDate":"2026-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13006972/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147514689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to: Difficulties in emotion regulation, repetitive negative thinking, and sexual and psychological distress: a two-wave longitudinal mediation study using a transdiagnostic approach.","authors":"","doi":"10.1093/sexmed/qfag016","DOIUrl":"10.1093/sexmed/qfag016","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.1093/sexmed/qfaf052.].</p>","PeriodicalId":21782,"journal":{"name":"Sexual Medicine","volume":"14 2","pages":"qfag016"},"PeriodicalIF":2.0,"publicationDate":"2026-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13006969/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147514695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Selective serotonin reuptake inhibitor and serotonin-norepinephrine reuptake inhibitor use and sexual dysfunction: a pharmacovigilance analysis.","authors":"Mengting Shen, Luyao He, Pei Chen, Lei Zhang, Duan Zeng, Yan Li, Huafang Li","doi":"10.1093/sexmed/qfag008","DOIUrl":"10.1093/sexmed/qfag008","url":null,"abstract":"<p><strong>Background: </strong>In clinical practice, selective serotonin reuptake inhibitors (SSRIs) and serotonin-norepinephrine reuptake inhibitors (SNRIs) remain commonly used owing to their proven antidepressant efficacy, however, they are also associated with a considerable risk of sexual adverse effects.</p><p><strong>Aim: </strong>To examine the relationship between individual SSRIs/SNRIs and distinct sexual dysfunction symptoms.</p><p><strong>Methods: </strong>Using the Food and Drug Administration's Adverse Event Reporting System (FAERS) database, we performed a pharmacovigilance analysis of adverse drug events. Disproportionality signals were detected using reporting odds ratios (RORs) and information components (ICs), with Bayesian shrinkage transformation applied to mitigate random variability.</p><p><strong>Outcomes: </strong>The primary outcome indicators are RORs and ICs, which were employed to evaluate the association between SSRIs and SNRIs and the development of sexual dysfunction.</p><p><strong>Results: </strong>Comparative analysis of antidepressant-related adverse events in the FAERS database showed that while sexual dysfunction was associated with all studied SSRIs/SNRIs (sertraline, citalopram/escitalopram, paroxetine, fluoxetine, venlafaxine, and duloxetine), symptom profiles varied markedly. Sertraline presented the most diverse array of sexual dysfunction manifestations, contrasting with duloxetine's relatively restricted adverse effect profile.</p><p><strong>Clinical implications: </strong>This study provides valuable real-world evidence to assist clinicians in optimizing antidepressant selection, proactively identifying high-risk populations for sexual dysfunction, and improving patient compliance and quality of life during antidepressant treatment.</p><p><strong>Strengths and limitations: </strong>The use of FAERS offers large-scale real-world data on antidepressant-related sexual dysfunction to enhance generalizability. But the limitation is FAERS' passive surveillance nature, which may involve underreporting or insufficient clinical context, restricting causal inference.</p><p><strong>Conclusion: </strong>While previous studies have not fully elucidated antidepressant-related sexual dysfunction, our findings delineate distinct sexual adverse effect profiles between SSRIs and SNRIs, contributing valuable evidence for personalized treatment approaches.</p>","PeriodicalId":21782,"journal":{"name":"Sexual Medicine","volume":"14 2","pages":"qfag008"},"PeriodicalIF":2.0,"publicationDate":"2026-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13006967/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147514701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perception of aesthetic procedures applied to the vulva in the context of the medical specialty of gynecology and obstetrics.","authors":"Vera Lúcia Mota da Fonseca, Jorge Artur Peçanha de Miranda Coelho, Gustavo Henrique Silva de Souza, Emanuel Duarte de Almeida Cordeiro, José Humberto Belmino Chaves, Rui Manuel Lopes Nunes","doi":"10.1093/sexmed/qfag003","DOIUrl":"https://doi.org/10.1093/sexmed/qfag003","url":null,"abstract":"<p><strong>Background: </strong>Female genital cosmetic surgery (FGCS), particularly labiaplasty, has gained increasing visibility and demand in clinical practice.</p><p><strong>Aim: </strong>To examine the perceptions of gynecology physicians and residents regarding ethical aspects and knowledge related to FGCS, with a focus on labiaplasty.</p><p><strong>Methods: </strong>A cross-sectional study was conducted with 404 physicians, including 327 (80.9%) women and 77 (19.1%) men. Participants completed a structured questionnaire assessing their ethical perspectives on vulvovaginal cosmetic procedures and their specific knowledge of interventions such as labiaplasty, hymenoplasty, clitoroplasty, and others.</p><p><strong>Outcomes: </strong>Differences in ethical views and knowledge levels between experienced physicians and residents were evaluated.</p><p><strong>Results: </strong>The findings revealed no significant differences between physicians and residents in ethical perceptions of labiaplasty. However, more experienced physicians reported greater exposure to patients seeking these procedures and demonstrated higher levels of knowledge regarding specific techniques.</p><p><strong>Clinical implications: </strong>Despite greater clinical exposure, ethical perspectives seem to be shaped early during academic training, underscoring the importance of formal education on FGCS.</p><p><strong>Strengths and limitations: </strong>This study provides insights into a relatively underexplored topic in medical education. However, the use of self-reported measures and a cross-sectional design may limit causal interpretations.</p><p><strong>Conclusion: </strong>Ethical perceptions of FGCS are consistent across levels of clinical experience, suggesting a strong influence of medical training and reinforcing the need for structured discussions on the topic in educational curricula.</p>","PeriodicalId":21782,"journal":{"name":"Sexual Medicine","volume":"14 1","pages":"qfag003"},"PeriodicalIF":2.0,"publicationDate":"2026-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12907013/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146213670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the temporal relationship between psychosocial risk factors and recurrent ischemic priapism.","authors":"Devin M Dishong, Mark Essien, Yuezhou Jing, Arthur L Burnett","doi":"10.1093/sexmed/qfag005","DOIUrl":"https://doi.org/10.1093/sexmed/qfag005","url":null,"abstract":"<p><strong>Background: </strong>The development of recurrent ischemic priapism (RIP) is associated with mental health disorders, psychiatric medications, and substance use, but the temporal relationship between the onset of RIP and the development of these risk factors is poorly understood.</p><p><strong>Aim: </strong>This study aimed to investigate the chronology of psychosocial and substance use risk factors relative to the initial clinical presentation of RIP.</p><p><strong>Methods: </strong>We conducted a retrospective cohort study of 73 adult patients diagnosed with RIP at a single academic center, identified via manual chart review of the electronic health record. Patients presenting with RIP between 2004 and 2020 were included, with data collection extending to 2025 to ensure a minimum follow-up of nearly 5 years for all participants to minimize censoring bias and capture delayed risk factor onset.</p><p><strong>Outcomes: </strong>The date of the first RIP presentation (index event) was compared to the first documented date of several risk factors, including anxiety, depression, psychiatric medication use, and substance use.</p><p><strong>Results: </strong>In the overall cohort, there was no statistically significant difference in the proportion of any risk factor developing before versus after the onset of RIP. Further, in a sub-analysis of 35 patients with sickle cell disease (SCD), a higher proportion of patients initiated psychiatric medication after the onset of RIP, although this was not statistically significant (<i>P</i> = .0522). No other factors reached statistical significance in the SCD sub-analysis.</p><p><strong>Clinical implications: </strong>The findings suggest that RIP may be a psychologically traumatic event that contributes to the development of the same psychosocial risk factors it is associated with.</p><p><strong>Strengths and limitations: </strong>The primary strength of this study is its novel investigation into the temporal relationship between RIP and psychosocial risk factors, supported by a design that ensured a minimum follow-up period of over 4 years for all participants. Limitations are primarily related to its retrospective, single-center chart-review design.</p><p><strong>Conclusion: </strong>Our findings suggest a complex, potentially bidirectional relationship that highlights the need for integrated mental health screening for all patients with RIP, particularly for the high-risk SCD population.</p>","PeriodicalId":21782,"journal":{"name":"Sexual Medicine","volume":"14 1","pages":"qfag005"},"PeriodicalIF":2.0,"publicationDate":"2026-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12907015/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146214125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Non-pharmacological interventions for sexual health in multiple sclerosis: a systematic review and meta-analysis.","authors":"Hikmat Hadoush PhD, Abdallah Al Hassoun MSc, Mohammad Al-Wardat PhD, Mohammad Etoom PhD, Alham Al-Sharman PhD","doi":"10.1093/sexmed/qfaf102","DOIUrl":"10.1093/sexmed/qfaf102","url":null,"abstract":"<p><strong>Background: </strong>Multiple sclerosis (MS), a neurodegenerative disease, frequently causes sexual dysfunction (SD) besides the well-known motor impairment, which significantly reduces patients' quality of life (QOL).</p><p><strong>Aim: </strong>This meta-analysis evaluates the effectiveness of non-pharmacological interventions for MS-related SD.</p><p><strong>Methods: </strong>Following Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, a systematic search of PubMed, ScienceDirect, CINAHL, and Cochrane databases identified randomized and clinical trials; data were extracted, the risk of bias was assessed, and meta-analyses were conducted.</p><p><strong>Outcomes: </strong>The primary outcomes were changes in sexual function, satisfaction, and QOL.</p><p><strong>Results: </strong>A total of 34 studies were included and eligible for meta-analysis. Pooled analyses revealed that yoga did not significantly improve sexual function standardized mean difference (SMD = -0.18, <i>P</i> = .84). However, structured exercise protocols (treadmill, aerobic, and aquatic exercises) showed significant improvements in sexual function (SMD = 2.88, <i>P</i> = .04), with aquatic exercise being particularly effective (SMD = 14.76, <i>P</i> = .0001). Mindfulness interventions also enhanced sexual function (SMD = 4.40, <i>P</i> < .0001). While psychoeducational programs did not significantly improve overall sexual QOL (SMD = 16.40, <i>P</i> = .18), they significantly improved sexual function (SMD = 3.46, <i>P</i> = .004) and satisfaction (SMD = 7.73, <i>P</i> = .028).</p><p><strong>Clinical implication: </strong>Tailored exercise and psychoeducational interventions can be recommended to improve sexual function and satisfaction in patients with MS.</p><p><strong>Strengths and limitations: </strong>Strengths include adherence to Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines and comprehensive analysis; limitations are the heterogeneity of interventions and the short-term nature of the included studies.</p><p><strong>Conclusion: </strong>Tailored exercise and psychoeducation significantly benefit sexual function in MS, while other therapies like yoga require refinement; future research should investigate long-term outcomes and patient-specific factors.</p>","PeriodicalId":21782,"journal":{"name":"Sexual Medicine","volume":"14 1","pages":"qfaf102"},"PeriodicalIF":2.0,"publicationDate":"2026-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12879193/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146143466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Baseline sexual function of patients receiving gender-affirming hysterectomies.","authors":"Allison J de Moya, Katarina Q Watson, Tami S Rowen","doi":"10.1093/sexmed/qfag001","DOIUrl":"10.1093/sexmed/qfag001","url":null,"abstract":"<p><strong>Background: </strong>While there are data showing the effects of gender-affirming hormone therapy on sexual satisfaction in transgender and gender-diverse individuals, there is no research on sexual function in patients seeking or undergoing gender-affirming hysterectomy (GAH).</p><p><strong>Aim: </strong>This project is a descriptive study of baseline characteristics (pre-hysterectomy) in patients seeking GAH.</p><p><strong>Methods: </strong>Twenty participants at a single tertiary care center were surveyed on orgasm satisfaction (Orgasm Rating Scale), and sexual function (Transmasculine Sexual Functioning Index).</p><p><strong>Results: </strong>The study sample (<i>n</i> = 20) was largely white, college-educated, between the ages of 21 and 35 years old. Most participants identified as transmasculine/transgender men and 75% were on testosterone therapy. No significant differences were observed in Orgasm Rating Scale subscales. The median Transmasculine Sexual Functioning Index sexual function score (20) corresponded with \"moderate\" sexual function.</p><p><strong>Conclusion: </strong>This study should be replicated in a larger, more diverse sample, with stratification across hormone therapy use, and longitudinal follow-up to assess for change in sexual function over time.</p>","PeriodicalId":21782,"journal":{"name":"Sexual Medicine","volume":"14 1","pages":"qfag001"},"PeriodicalIF":2.0,"publicationDate":"2026-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12860200/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146107123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}