Sexual Medicine最新文献

{"title":"South Asian Society for Sexual Medicine School, Bangladesh: a multidisciplinary training initiative in an under-resourced country.","authors":"Mohammad Shamsul Ahsan, Leuza Mubassara, A K M Anwarul Islam, Md Mahbubul Hasan, Shahjada Selim, Rubaiya Ali, Mohtasham Hasan, Md Kamrul Hossain","doi":"10.1093/sexmed/qfaf028","DOIUrl":"https://doi.org/10.1093/sexmed/qfaf028","url":null,"abstract":"<p><strong>Background: </strong>The yearly courses conducted by the South Asian Society for Sexual Medicine (SASSM) in Bangladesh establish a collaborative training paradigm designed to increase healthcare professionals' comfort with sexual medicine and develop skills for giving the best treatment possible to individuals with sexual health issues and dysfunctions.</p><p><strong>Aim: </strong>The study assessed the impact of course completion on SASSM School Bangladesh participants.</p><p><strong>Methods: </strong>A pretest-posttest of 116 (57%) SASSM participants was conducted, comprising data on knowledge acquisition following the 3-day program in 2017, 2018, 2019, and 2021. A paired <i>t</i>-test was applied to compare the difference between pretest and posttest performance. Logistic regression was conducted to assess the influence of socio-demographic variables.</p><p><strong>Outcomes: </strong>The study demonstrates that the SASSM School Bangladesh program significantly improves participants' knowledge of sexual medicine, with a 12.7-unit increase in test scores, irrespective of socio-demographic factors.</p><p><strong>Results: </strong>Majority (102, or 75% of those polled) of the participants were men. Psychiatrists were the most common respondents (39%), followed by dermatologists (32%), urologists (12%), and gynecologists (8%) who completed both surveys. There was a significant difference (<i>P</i>-value < .01) in mean pretest (49.6 ± 17.1) and posttest (62.3 ± 15.5) scores. The socio-demographic factors (gender, location, age, and experience) do not have any significant influence on gain of knowledge through the SASSM training program as the <i>P</i>-value of odds ratio or adjusted odds ratio from logistic regression is <i>P</i> > .05.</p><p><strong>Clinical implications: </strong>The study highlights the clinical importance of structured training in sexual medicine, ensuring that healthcare professionals across various specialties are better equipped to diagnose and manage sexual health issues effectively.</p><p><strong>Strengths and limitations: </strong>The study used a pretest-posttest design to measure actual knowledge improvement. Paired <i>t</i>-test and logistic regression were applied to ensure robust analysis. Diverse professionals from psychiatry, dermatology, urology, and gynecology participated in the study, making the findings relevant across specialties. This study evaluates the only structured sexual medicine training program in Bangladesh, contributing new insights into medical education.However, the findings may not be generalizable beyond Bangladesh. The study could not assess whether knowledge retention and clinical practice improved over time. Participants voluntarily enrolled in the study, which can possibly represent a group already interested in sexual medicine. The study focused only on knowledge improvement, not on changes in clinical practice or patient outcomes.</p><p><strong>Conclusion: </strong>Specialists o","PeriodicalId":21782,"journal":{"name":"Sexual Medicine","volume":"13 2","pages":"qfaf028"},"PeriodicalIF":2.6,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12041646/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144046262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sexual dysfunctions in patients with well-compensated chronic liver disease: role of etiology, Mediterranean diet and quality of life in an observational cross-sectional study.","authors":"Lorenzo Romano, Mariano Fonticelli, Filomena Morisco, Kateryna Priadko, Alba Rocco, Gerardo Nardone, Luisa Ranieri, Luigi Napolitano, Felice Crocetto, Biagio Barone, Davide Arcaniolo, Lorenzo Spirito, Celeste Manfredi, Antonietta Gerarda Gravina, Carmine Sciorio, Antonio Tufano, Antonio Cioffi, Ferdinando Fusco, Marco Romano, Marco De Sio","doi":"10.1093/sexmed/qfaf025","DOIUrl":"https://doi.org/10.1093/sexmed/qfaf025","url":null,"abstract":"<p><strong>Background: </strong>Sexual dysfunctions (SD) are highly prevalent in Chronic Liver Diseases (CLD). Whether Metabolic dysfunction-Associated Steatotic Liver Disease (MASLD) carries a higher risk of SD is unknown as is the role of dietary patterns or quality of Life (QoL).</p><p><strong>Aim: </strong>to assess (1) prevalence of SD in CLD; (2) whether MASLD is a risk factor for SD; (3) the role of adherence to Mediterranean Diet (MD) or QoL.</p><p><strong>Methods: </strong>Observational, cross-sectional study, 207 CLD patients (84 females and 123 males), median age 57 years (IQR:46-63); 96 (46.4%) MASLD; and 111 (53.6%) nonMASLD.</p><p><strong>Outcomes: </strong>SD were assessed through Female Sexual Function Index (FSFI) and International Index of Erectile Function (IIEF) questionnaires. Adherence to MD was evaluated by the MD Score, QoL by SFHS-12 questionnaire evaluating physical [(ie, Physical Component Summary (PCS)] and mental [(ie, Mental Component Summary (MCS)] health. Multivariate analysis identified predictors of SD.</p><p><strong>Results: </strong>(1) SD prevalence in CLD was 157/207 (75.8%); 80.9% females were at risk for SD, altered sexual desire/arousal and dyspareunia being the most common complaints, whereas 72.3% males had erectile dysfunction (ED); (2) prevalence of SD was higher in MASLD (89%) than in nonMASLD (64%) (<i>P</i> < 0.001); (3) in females, at univariate analysis, a negative correlation was found between FSFI and age, hypertension, or MASLD; (4) in males, at univariate analysis, IIEF-ED negatively correlated with age, DM2, or MASLD, whereas positively correlated with PCS and MCS; (5) in females, at multivariate analysis BMI (OR = 0.779,CI 95% = 0.640-0.948) and MCS (OR = 0.840,CI 95% = 0.741-0.953) were protective against SD, whereas age (OR = 1.115,CI 95% = 1.040-1.263) and DM2 (OR = 120.894,CI 95% = 1.396-10 741) were predictive of SD; (6) in males, at multivariate analysis, age (OR = 1088,CI 95% = 1032-1.148) and MASLD (OR = 4.075,CI 95% = 1.120-14.828) were risk factors for, whereas PCS (OR = 0,928,CI 95% = 0,865-0,995), and disease duration (OR = 0.393,CI 95% = 0.187-0.822) were protective against SD; 7) MD adherence, while higher in nonMASLD vs MASLD (<i>P =</i> 0.004), was not an independent protective factor against SD.</p><p><strong>Clinical implications: </strong>SD should not be underestimated in CLD patients, in particular those with MASLD.</p><p><strong>Strengths and limitations: </strong>Comprehensive study evaluating SD in a large cohort of CLD patients of both sexes, comparing MASLD vs nonMASLD. Due to its cross-sectional design, no conclusions can be drawn about cause and effect.</p><p><strong>Conclusions: </strong>(1) CLD, in particular MASLD, have a high prevalence of SD which is not affected by MD adherence, whereas QoL seems to play a role; (2) CLD patients should be evaluated for SD, for early diagnosis and treatment.</p>","PeriodicalId":21782,"journal":{"name":"Sexual Medicine","volume":"13 2","pages":"qfaf025"},"PeriodicalIF":2.6,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12018302/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144007524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"AI-assisted transcription of YouTube videos on penile enlargement: analysis of their text quality and readability.","authors":"Mehmet Fatih Şahin, Erdem Can Topkaç, Çağrı Doğan, Serkan Şeramet, Furkan Batuhan Tuncer, Muhammed Sencer Köroğlu, Onur Orbeği, Cenk Murat Yazici","doi":"10.1093/sexmed/qfaf023","DOIUrl":"https://doi.org/10.1093/sexmed/qfaf023","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Patients dealing with sensitive issues like penile enlargement (PE) might benefit from YouTube videos. Therefore, it is essential that the textual content of these videos is clear, trustworthy, and of high quality.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Aim: &lt;/strong&gt;Are the AI-assisted acquired texts' qualities and comprehensibilities of YouTube videos about PE enough and suitable for the patients?&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;On October 25, 2024, Google Trends analysis identified the 25 most searched phrases for \"Penile enlargement.\" Non-related terms were excluded, and the relevant keywords were searched on YouTube. Only content about PE included; excluding duplicates, non-English videos, YouTube shorts, those under 30 seconds, silent, and music-only videos. Videos were transcribed using Whisper AI, and their quality was assessed by M.F.Ş, E.C.T., and Ç.D. using the GQS (global quality scale) and DISCERN, the readability was evaluated via Flesch-Kincaid (FKGL and FKRE) measures. High assessor agreement was noted (Pearson r = 0.912). Videos were categorized by uploader, and metrics such as views, likes, comments, and duration were recorded. The Chi-square test was used for categorical variable comparisons; the Kruskal-Wallis H-Test was applied when normality and homoscedasticity were not met, with Bonferroni post hoc correction for multiple comparisons.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Outcomes: &lt;/strong&gt;The mean DISCERN and GQS scores were 51.23 ± 13.1 and 3.32 ± 0.9, respectively. FKRE and FKGL scores were 73.12 ± 11.7 and 5.85 ± 2.1. Physicians (n = 67) produced the most videos, while academic institutions (n = 2) produced the least. No significant differences in text quality were found between groups (&lt;i&gt;P&lt;/i&gt; = 0.067 and &lt;i&gt;P&lt;/i&gt; = 0.051). Health-related websites exhibited lower FKRE compared to non-healthcare videos (&lt;i&gt;P&lt;/i&gt; = &lt;b&gt;0.002&lt;/b&gt;), with a significant difference in FKGL as well (&lt;i&gt;P&lt;/i&gt; = &lt;b&gt;0.019&lt;/b&gt;).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;The video exhibited a high level of readability (indicating comprehensibility for almost a 6th-grade student). Text quality, view and like count of the videos uploaded by academic institutions was the highest.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Clinical implications: &lt;/strong&gt;In PE, YouTube video's health information needs to be better quality and more trustworthy, according to our research. The language used in videos should be easier to understand.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Strengths and limitations: &lt;/strong&gt;This study is the first scientific analysis of YouTube video transcripts on PE using AI, focusing specifically on English content, which limits its applicability to non-English speakers and other platforms. Exclusions of silent and shorter videos may result in the omission of valuable information.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;The need for better quality and trustworthiness in health-related YouTube information, especially for PE is essential. Content makers should stress clear, accessible language and minimize disinformation.","PeriodicalId":21782,"journal":{"name":"Sexual Medicine","volume":"13 2","pages":"qfaf023"},"PeriodicalIF":2.6,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12011079/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144012408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Methods, practices, and complications related to the use of artificial penile nodules within the French Guiana penitentiary.","authors":"Jeremy Vergez, Anaïs Baudot, Loïc Epelboin, Sébastien Rabier, Evelyn Vienrendeels, Mathieu Nacher, Aude Lucarelli, Timothee Bonifay","doi":"10.1093/sexmed/qfaf022","DOIUrl":"https://doi.org/10.1093/sexmed/qfaf022","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Artificial penile nodules (APNs) are small, handmade objects inserted under the penile skin, a practice deeply rooted in the prison environment of French Guiana, raising significant concerns related to sexual health, including complications and an increased risk of sexually transmitted infections (STIs).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Aim: &lt;/strong&gt;The primary objective of the current study was to investigate APN practices, methods, and complications in prison and to identify risk factors for complications among APN users and their sexual partners.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;This cross-sectional study was conducted among adult male detainees in June 2023 at the French Guiana Penitentiary (FGP). Eligible participants completed an anonymous 47-question survey addressing sociodemographic data, APN practices, and sexual health. Facilitators played a critical role in distributing and collecting the questionnaires, which were available in five languages to accommodate the prison's population ethnogeographic diversity. Data analysis was conducted using logistic regression to identify risk factors associated with complications.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Outcomes: &lt;/strong&gt;Outcomes included the prevalence of APN use among detainees, the proportion of individuals experiencing complications, the association between APN characteristics (number and placement) and partner-related complications, as well as the rates of condom breakage and self-reported STI history.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;Among 779 eligible detainees, 132 participated (17%). The majority were under 35 years old (67%), and 69% reported having APNs, with a median of 5.2 nodules per user (range: 1-22). The main motivation for APN use was enhancing partner satisfaction (60%), while 5% cited intent to harm. Complications were reported by 25%, including pain (52%), bleeding (41%), and infections (35%). Partner-related complications (pain or bleeding) were significantly associated with having five or more APNs and placement in the foreskin of the penis.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Clinical implications: &lt;/strong&gt;Given the high prevalence of APNs in the prison setting and their associated health risks, targeted health education and harm reduction strategies are essential to mitigate complications and promote informed decision-making among detainees.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Strengths and limitations: &lt;/strong&gt;The main limitation of this study was its reliance on self-reported questionnaires completed in cells, which may have affected confidentiality, response accuracy, and participation due to prison dynamics and literacy barriers. However, the approach provided valuable insight into a stigmatized topic, and collaboration with facilitators and staff helped achieve meaningful participation.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;APNs are deeply rooted in prison culture in French Guiana but pose significant health risks. Findings underscore the need for targeted health education to address these risks, particularly f","PeriodicalId":21782,"journal":{"name":"Sexual Medicine","volume":"13 2","pages":"qfaf022"},"PeriodicalIF":2.6,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12011078/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144047684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the Editor on \"Association of total testosterone levels with cardiometabolic diseases in men with erectile dysfunction\".","authors":"Scott Selinger, Gregory R Thoreson","doi":"10.1093/sexmed/qfaf020","DOIUrl":"10.1093/sexmed/qfaf020","url":null,"abstract":"","PeriodicalId":21782,"journal":{"name":"Sexual Medicine","volume":"13 2","pages":"qfaf020"},"PeriodicalIF":2.6,"publicationDate":"2025-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11972624/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143796354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to Letter to the Editor on \"The associations among platelet count, mean platelet volume, and erectile dysfunction: an observational and Mendelian randomization study\".","authors":"Jingxuan Peng, Jinshun An, Yuxing Chen, Jun Zhou, Boyu Xiang","doi":"10.1093/sexmed/qfaf016","DOIUrl":"10.1093/sexmed/qfaf016","url":null,"abstract":"","PeriodicalId":21782,"journal":{"name":"Sexual Medicine","volume":"13 2","pages":"qfaf016"},"PeriodicalIF":2.6,"publicationDate":"2025-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11972656/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143796446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the Editor on \"The associations among platelet count, mean platelet volume, and erectile dysfunction: an observational and Mendelian randomization study\".","authors":"Yuekun Fang, Shengyi Chen, Chenxiao Huang, Bin Cheng","doi":"10.1093/sexmed/qfaf015","DOIUrl":"10.1093/sexmed/qfaf015","url":null,"abstract":"","PeriodicalId":21782,"journal":{"name":"Sexual Medicine","volume":"13 2","pages":"qfaf015"},"PeriodicalIF":2.6,"publicationDate":"2025-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11972627/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143796439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Menopause is associated with a decrease in sexual function among women with endometriosis.","authors":"Alexandre Vallée, Pierre-François Ceccaldi, Jean-Marc Ayoubi","doi":"10.1093/sexmed/qfaf019","DOIUrl":"10.1093/sexmed/qfaf019","url":null,"abstract":"<p><strong>Background: </strong>Menopause-related endocrinological shifts are linked to sexual dysfunction, and women with endometriosis exhibit lower Female Sexual Function Index (FSFI) scores, indicating impaired sexual well-being.</p><p><strong>Aim: </strong>To assess the impact of menopause on sexual function in women with endometriosis.</p><p><strong>Methods: </strong>An anonymous online survey was conducted among 1586 French women diagnosed with endometriosis. The FSFI questionnaire was used to evaluate sexual function, and menopause was defined as ≥12 months of amenorrhea. Multivariable logistic regression was performed to assess the relationship between FSFI scores and menopause status, adjusting for tobacco use, education, number of symptoms, and history of surgery. Logworth analyses were used to determine the strongest components of FSFI associated with menopause.</p><p><strong>Outcomes: </strong>The primary outcome was the FSFI total score and its six domains (desire, arousal, vaginal lubrication, orgasm, satisfaction, and dyspareunia) in menopausal and non-menopausal women with endometriosis.</p><p><strong>Results: </strong>Menopausal women had significantly lower FSFI scores (15.3 vs. 16.9, <i>P</i> = 0.021). After adjustment, FSFI remained significantly lower (<i>P</i> = 0.026) in menopausal women but did not reach the established FSFI cutoff for sexual dysfunction (<i>P</i> = 0.451). Stratified analysis by age showed a steep decline in FSFI between 46 and 50 years, partial improvement at 51-55 years, and further decline after 55 years, particularly in arousal, orgasm, dyspareunia, and satisfaction. Arousal (logworth = 4.53, <i>P</i> < 0.001) was the most affected domain, followed by satisfaction (logworth = 1.81, <i>P</i> = 0.015).</p><p><strong>Clinical implications: </strong>Arousal appears to be the key determinant of sexual function decline in menopausal women with endometriosis, highlighting the need for targeted interventions such as hormone therapy, pain management, and sexual counseling.</p><p><strong>Strengths & limitations: </strong>The study benefits from a large sample size and validated FSFI assessment but is limited by selection bias from online recruitment, self-reported diagnosis of endometriosis, and lack of hormonal status confirmation. The cross-sectional design prevents causal inferences.</p><p><strong>Conclusion: </strong>Menopause is associated with a decline in FSFI scores among women with endometriosis, with arousal being the most affected domain, underscoring the need for further research on personalized management strategies for sexual dysfunction in this population.</p>","PeriodicalId":21782,"journal":{"name":"Sexual Medicine","volume":"13 2","pages":"qfaf019"},"PeriodicalIF":2.6,"publicationDate":"2025-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11972087/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143796443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Icariin inhibits hyperglycemia-induced cell death in penile cavernous tissue and improves erectile function in type 1 diabetic rats.","authors":"Haowei Yang, Wenju Xiong, Jun Jiang, Rui Jiang","doi":"10.1093/sexmed/qfaf017","DOIUrl":"10.1093/sexmed/qfaf017","url":null,"abstract":"<p><strong>Background: </strong>Hyperglycemia can cause endothelial cell (EC) and smooth muscle cell (SMC) death in the penile cavernous tissue of rats and lead to erectile dysfunction (ED).</p><p><strong>Objectives: </strong>To investigate the proportions of apoptotic, pyroptotic, and ferroptotic cells among ECs and SMCs in the penile cavernous tissue of type 1 diabetic (T1DM) rats and the mechanism by which icariin (ICA) improves the erectile function of T1DM rats.</p><p><strong>Methods: </strong>A total of 24 9-week-old Sprague-Dawley (SD) rats were randomly divided into 4 groups (<i>n</i> = 6): control group, control + ICA group, diabetic mellitus (DM) group, and DM + ICA group. T1DM rats were generated via the intraperitoneal injection of STZ (45 mg/kg). After 8 weeks, the rats in the control + ICA group and the DM + ICA group were administered ICA (10 mg/kg/d) by gavage for 4 weeks. ROS, MDA, SOD, GSH, SM/C, and NO levels, and GPX4, ACSL4, caspase-1, GSDMD, caspase-3, CD31, α-SMA, and p-eNOS/eNOS expression in penile cavernous tissue and the ICPmax/MAP of 21-week-old rats were detected.</p><p><strong>Results: </strong>The percentage of pyroptotic SMCs in penile cavernosum was no statistically significant difference among these groups. Vs control group, the percentages of apoptotic (20.70% ± 1.60%), pyroptotic (21.02% ± 1.97%), and ferroptotic (9.01% ± 2.00%) ECs and the percentages of apoptotic (15.47% ± 1.36%) and ferroptotic (26.33% ± 3.11%) SMCs in the penile cavernous tissue of the DM group were significantly greater. Vs DM group, the percentages of apoptotic (9.13% ± 1.28%), pyroptotic (13.22 ± 1.26%), and ferroptotic (4.01% ± 0.86%) ECs and the percentages of apoptotic (11.60% ± 1.91%) and ferroptotic (12.71% ± 2.92%) SMCs of the DM + ICA group were significantly lower. Vs the DM group, the levels of caspase-1, GSDMD, ACSL4, and ROS were significantly lower in the penile cavernous tissue of the DM + ICA group. Meanwhile, the levels of GPX4 and maximum intracavernous pressure/mean arterial pressure (ICPmax/MAP) were significantly higher.</p><p><strong>Clinical implications: </strong>The combined inhibition of apoptosis, pyroptosis, and ferroptosis in penile cavernous tissue by ICA provides a theoretical basis for the clinical development of multi-target drugs for the treatment of type 1 diabetes-induced ED.</p><p><strong>Strengths and limitations: </strong>Further experiments are required to clarify whether other types of cell death are involved in the loss of ECs and SMCs in the penile cavernous tissue of T1DM rats.</p><p><strong>Conclusion: </strong>Inhibiting oxidative stress and thereby inhibiting apoptosis, pyroptosis, and ferroptosis in ECs and SMCs of penile cavernous tissue constitute one of the mechanisms through which ICA improves erectile function in T1DM rats.</p>","PeriodicalId":21782,"journal":{"name":"Sexual Medicine","volume":"13 1","pages":"qfaf017"},"PeriodicalIF":2.6,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11950537/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143754417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the editor on \"No bidirectional association between serum 25-hydroxyvitamin D and erectile dysfunction: Mendelian randomization and genetic association studies\".","authors":"Xingcheng Zhu, Junxian Zhao, Mengjun Tang, Shi Fu, Jieming Zuo, Junhao Chen","doi":"10.1093/sexmed/qfaf018","DOIUrl":"10.1093/sexmed/qfaf018","url":null,"abstract":"","PeriodicalId":21782,"journal":{"name":"Sexual Medicine","volume":"13 1","pages":"qfaf018"},"PeriodicalIF":2.6,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11950526/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143754420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}