Sexual Medicine最新文献

{"title":"Study of psychosocial factors affecting premature ejaculation from the perspective of personality traits: a large sample cross-sectional study from Anhui, China.","authors":"Jingjing Gao, Rui Gao, Kun Wang, Guosheng Xu, Zifang Zhang, Xiaodong Bai, Jishuang Liu, Kai Shi, Jun Mao, Yao Zhang, Xiansheng Zhang","doi":"10.1093/sexmed/qfaf094","DOIUrl":"10.1093/sexmed/qfaf094","url":null,"abstract":"<p><strong>Background: </strong>Personality traits are the intrinsic factors of mental health, and may play a role in the pathogenesis of premature ejaculation (PE), but few studies have evaluated the association between personality traits and the 4 types of PE.</p><p><strong>Aim: </strong>We aim to investigate the personality traits associated with PE in 4 types of PE and their associations with PE.</p><p><strong>Methods: </strong>Between February 2024 and February 2025, we conducted a survey in Anhui, China, and enrolled 1708 males. Personality traits were independently assessed by the Myers-Briggs Type Indicator (MBTI). The index of PE was used to evaluate ejaculation control, sexual life satisfaction, and distress caused by PE.</p><p><strong>Outcomes: </strong>Energy-Introversion, Perceiving-Sensing, Judging-Feeling, and Orientation-Perception may influence men's sexual activity, and the Energy, Perceiving, and Orientation have different effects on the 4 types of PE.</p><p><strong>Results: </strong>The ISFP personality type is most common in those with PE. Among the 4 subtypes of PE, the Introversion-Intuition-Feeling-Perceiving (INFP) personality type is most common in those with Lifelong PE (LPE), the Extraversion-Sensing-Feeling-Judging (ESFJ) personality type is most common in those with Acquired PE (APE), the Introversion-Sensing-Feeling-Perceiving (ISFP) personality type is most common in those with Variable PE (VPE), and the Extraversion-Sensing-Feeling-Perceiving (ESFP) personality type is most common in those with Subjective PE (SPE).</p><p><strong>Clinical implications: </strong>Personality trait factors may influence the pathogenesis of PE, and the use of the MBTI personality assessment provides a new perspective on how personality traits play a role in the onset of PE.</p><p><strong>Strengths & limitations: </strong>It is necessary to conduct larger-scale, more rigorous community-based studies to further elucidate the role of personality traits in the development of PE.</p><p><strong>Conclusion: </strong>Men with traits of Introversion, Sensing, Feeling, and Perception tend to have high sensitivity, introspection, and a deep pursuit of idealized relationships.</p>","PeriodicalId":21782,"journal":{"name":"Sexual Medicine","volume":"13 5","pages":"qfaf094"},"PeriodicalIF":2.4,"publicationDate":"2025-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12619530/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145542393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Two sides of the same coin? Prevalence and co-occurrence of binge eating disorder and compulsive sexual behavior disorder in a representative sample of the Polish population.","authors":"Ewelina Kowalewska, Michał Lew-Starowicz","doi":"10.1093/sexmed/qfaf092","DOIUrl":"10.1093/sexmed/qfaf092","url":null,"abstract":"<p><strong>Background: </strong>Although increasingly recognized, research into the prevalence and co-occurrence of binge eating disorder (BED) and compulsive sexual behavior disorder (CSBD) remains scarce.</p><p><strong>Aim: </strong>To evaluate the prevalence and co-occurrence of BED and CSBD in a representative Polish population while examining their associations with sexual behavior-related variables, and levels of anxiety and depression.</p><p><strong>Methods: </strong>Data were collected from a representative sample of Polish adults, consisting of 1527 participants aged 18-65.</p><p><strong>Outcomes: </strong>The occurrence and intersection of symptoms of BED and CSBD.</p><p><strong>Results: </strong>Men reported significantly higher CSBD symptoms (<i>Z</i> = 9.62, <i>P</i> < .001, <i>d</i> = 0.52) and problematic sexual behaviors, while women reported higher BED (<i>Z</i> = 5.51, <i>P</i> < .001, <i>d</i> = 0.30) and anxiety symptoms (<i>Z</i> = 7.46, <i>P</i> < .001, <i>d</i> = 0.39). BED and CSBD symptoms co-occurred significantly in men (<i>χ</i> ²(1) = 59.00, <i>P</i> < .001), but not in women (<i>χ</i> ²(1) = 1.51, <i>P</i> = .22). BED symptoms were positively correlated with anxiety (<i>r</i> = 0.46, <i>P</i> < .001) and depression (<i>r</i> = 0.47, <i>P</i> < .001), highlighting their interplay with psychological distress.</p><p><strong>Clinical implications: </strong>Findings underscore shared mechanisms across BED and CSBD, suggesting the potential effectiveness of transdiagnostic treatment approaches addressing co-occurring symptoms, emotional regulation, and impulsivity within a unified therapeutic framework.</p><p><strong>Strengths and limitations: </strong>Strengths include a representative sample and the examination of underexplored comorbidity patterns. Limitations include the cross-sectional design and reliance on self-report measures, warranting longitudinal and multimethod research for causal inferences.</p><p><strong>Conclusion: </strong>This study reveals significant gender differences in BED and CSBD symptoms and demonstrates their co-occurrence among men, emphasizing the need for gender-sensitive, integrated clinical approaches to assessment and treatment.</p>","PeriodicalId":21782,"journal":{"name":"Sexual Medicine","volume":"13 5","pages":"qfaf092"},"PeriodicalIF":2.4,"publicationDate":"2025-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12597027/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145489513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Virtual versus in-person sexual rehabilitation for prostate cancer survivors: a retrospective cohort study comparing the Prostate Cancer Rehabilitation Clinic (PCRC) and the True North Sexual Health and Rehabilitation eClinic (SHAReClinic).","authors":"Andrew G Matthew, Steven Guirguis, Taylor Incze, Dalia Peres, Richard J Wassersug, Lauren Walker, John W Robinson, Deborah McLeod, Stacy Elliott, Antionio Finelli, Neil Fleshner, Leah Jamnicky, Shiyi Chen, Dean Elterman","doi":"10.1093/sexmed/qfaf088","DOIUrl":"10.1093/sexmed/qfaf088","url":null,"abstract":"<p><strong>Background: </strong>Sexual dysfunction is a common and distressing consequence of prostate cancer (PCa) treatment, yet few healthcare institutions offer comprehensive, systematic care, limiting equitable access. Virtual models may improve accessibility and efficiency without sacrificing effectiveness.</p><p><strong>Aim: </strong>To assess whether outcomes in the virtual Sexual Health and Rehabilitation eClinic (SHAReClinic) were comparable to those in the in-person Prostate Cancer Rehabilitation Clinic (PCRC) in improving sexual health outcomes for PCa survivors.</p><p><strong>Methods: </strong>A retrospective cohort chart review was conducted on PCa patients enrolled in either the PCRC or SHAReClinic between September 2017 and August 2018, with data collected 12 months post-treatment. Clinic assignment was based on standard care pathways. Sexual health outcomes were measured using the Sexual Health Inventory for Men (SHIM), Sexual Distress Scale (SDS), Male Sexual Health Questionnaire (MSIS), and Expanded Prostate Cancer Index Composite (EPIC-26). Pro-erectile medication usage was also analyzed.</p><p><strong>Outcomes: </strong>Primary outcomes were SHIM and SDS scores. Secondary outcomes included MSIS, EPIC-26 scores, and pro-erectile medication use as an indicator for adherence and ongoing sexual activity.</p><p><strong>Results: </strong>Among 98 PCa patients (55 PCRC, 43 SHAReClinic), no significant differences were found in SHIM and SDS scores. While partnered PCRC participants reported significantly higher intimacy on the MSIS compared to partnered SHAReClinic participants (<i>P</i> = .042), no significant differences were found on the EPIC-26 sexual health domain. Pro-erectile medication use was similar in both groups. Multivariable analyses showed comparable outcomes in sexual function, distress, and health-related quality of life, except for intimacy.</p><p><strong>Clinical implications: </strong>SHAReClinic yields comparable outcomes to PCRC and provides an effective, resource-efficient alternative to in-person sexual rehabilitation for PCa patients, particularly in settings with limited accessibility or resources.</p><p><strong>Strengths and limitations: </strong>This study provides a comprehensive assessment of sexual health outcomes; however, the small sample size limits generalizability. In addition, there was a significant imbalance in treatment modality, with radiation patients represented only in the SHAReClinic cohort. Further research in larger, more diverse populations with longer follow-up is needed to confirm these findings and better understand intimacy differences.</p><p><strong>Conclusion: </strong>SHAReClinic demonstrates outcomes comparable to PCRC in managing sexual dysfunction in PCa patients, offering a viable and accessible option for sexual rehabilitation.</p>","PeriodicalId":21782,"journal":{"name":"Sexual Medicine","volume":"13 5","pages":"qfaf088"},"PeriodicalIF":2.4,"publicationDate":"2025-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12596167/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145489456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors associated with compulsive sexual behavior in a national probability web-based aged 18-59 years sample from Japan: a cross-sectional survey.","authors":"Yushun Okabe, Daisuke Ito","doi":"10.1093/sexmed/qfaf091","DOIUrl":"10.1093/sexmed/qfaf091","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Compulsive sexual behavior disorder (CSBD) involves persistent, repetitive sexual behaviors that continue despite efforts to stop, leading to significant distress or impairment in personal, family, social, educational, and occupational functioning. Most compulsive sexual behavior (CSB) research focuses on Western countries, leaving its characteristics in Japan largely unexplored. Although treatment-seeking behavior for CSB is documented in Western contexts, there is a need to understand this behavior in Japan to improve mental health services.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Aims: &lt;/strong&gt;This cross-sectional study aimed to clarify association between CSB, sociodemographic factors, maximum sexual behavior duration, life satisfaction, negative consequences, psychological co-morbidities, and treatment-seeking behaviors in Japan.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;Participants were recruited from a national probability-based sample of adults aged 18-59 in Japan using a web-based questionnaire, with proportional representation of sex assigned at birth, age groups, and residential areas. A total of 1094 respondents (43.69% heterosexual cisgender men, &lt;i&gt;M&lt;/i&gt; &lt;sub&gt;age&lt;/sub&gt; = 39.9 ± 11.6) were included.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Outcomes: &lt;/strong&gt;Participants completed the Compulsive Sexual Behavior Disorder Scale-19 (mean score = 24.35 ± 9.27), reporting sexual behavior frequency, time spent on sexual behaviors, life satisfaction, negative consequences related to sexual behaviors, treatment-seeking behaviors, and comorbid conditions such as depression (Patient Health Questionnaire-9), anxiety (Generalized Anxiety Disorder-7), and Adult Attention-deficit Hyperactivity Disorder (ADHD) (Adult Attention-deficit Hyperactivity Disorder Self-Report Scale).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;Individuals at high risk of CSBD (&lt;i&gt;n&lt;/i&gt; = 28; 2.56%), based on the CSBD-19 cut-off score, were more likely to be cisgender heterosexual men than women (chi-squared test). Compared to low-risk individuals, those at high risk spent more maximum duration on pornography and masturbation, lower life satisfaction in health and intimate relationships, experienced negative consequences in various life domains (eg, sleep, social activities, work, family life, finances, and physical health), and exhibited symptoms of depression, anxiety, and ADHD. Three individuals at high risk of CSBD reported seeking treatment.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Clinical implications: &lt;/strong&gt;Individuals at high risk of CSBD experience negative consequences and psychological co-morbidities, making it critical to investigate contributing factors to provide effective treatment for CSB in Japan.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Strengths and limitations: &lt;/strong&gt;This study contributes to limited research on CSB in non-Western cultures using a nationally probability-based sample in Japan. The measures lacked detail, so future studies should include more specific questions to evaluate treatment-seeking and other conditions. The small sa","PeriodicalId":21782,"journal":{"name":"Sexual Medicine","volume":"13 5","pages":"qfaf091"},"PeriodicalIF":2.0,"publicationDate":"2025-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12586315/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145459639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sexual activities, erectile dysfunction, and the use of sexual management strategies among assigned males with genital ablation interests.","authors":"Erik Wibowo, Thomas W Johnson, Richard J Wassersug, Jamie D Agapoff","doi":"10.1093/sexmed/qfaf085","DOIUrl":"10.1093/sexmed/qfaf085","url":null,"abstract":"<p><strong>Background: </strong>Assigned males with genital ablation interests may be at higher risk of having erectile dysfunction (ED), especially those who have gone through androgen suppressing pharmacological therapies, orchiectomy and/or penectomy.</p><p><strong>Aim: </strong>To determine the prevalence and severity of ED in assigned males with castration interests, the types of management strategies they use and what factors are associated with using these strategies.</p><p><strong>Methods: </strong>We launched an online survey on the Eunuch Archive website to better understand how common ED is, as well as sexual frequencies, and the use of sexual management strategies among assigned males with genital ablation interests.</p><p><strong>Outcomes: </strong>ED and sexual activity frequencies, preferred role in sexual activities, and previous use of sexual management strategies.</p><p><strong>Results: </strong>Data from 363 assigned male individuals (50.7 ± 15.6 years old; 23.6% and 3.7% had been orchiectomized and penectomized respectively) showed that 11.2% reported having ED 25-50% of the time, 12.8% had ED 50-75% of the time, and 22.9% had ED 75-100% of the time. Yet a large proportion remained sexually active. For example, 63.5%, 56.2% and 8.8% reported watching porn, masturbating, and having partnered sex several times a week respectively. During partnered sex, 13% of the participants preferred to be in the insertive role, whereas nearly 40% preferred to be in the receptive role. A quarter preferred non-penetrative sex. To maintain sexual activities, commonly used strategies included oral medication (38.8%), vacuum erection devices (25.6%), and strap-on dildo (17.5%). Penile sleeve, penile injection and penile support device were rarely used (<10%).</p><p><strong>Clinical implications: </strong>Data from our study can be used by clinicians to advise their clients, for example individuals with genital ablation interest who seek to maintain their sexual activities.</p><p><strong>Strengths & limitations: </strong>Participants completed validated questionnaires. Data were collected online and could not be independently verified.</p><p><strong>Conclusions: </strong>A strong interest in genital ablation is often associated with a desire to be less sexual. Consistent with that is a high incidence of ED in this population. However, many men with exceptional interests in genital ablation nevertheless remain sexually active and use various strategies to maintain penetrative sex.</p>","PeriodicalId":21782,"journal":{"name":"Sexual Medicine","volume":"13 5","pages":"qfaf085"},"PeriodicalIF":2.0,"publicationDate":"2025-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12560766/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145401814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cognition of the association between sexual dysfunction and fertility.","authors":"Yuying Sheng, Lewen Ruan, Yuge Chen, Xu Han, Baoyan Wu, Mingrong Lv, Dongdong Tang, Kuokuo Li","doi":"10.1093/sexmed/qfaf084","DOIUrl":"10.1093/sexmed/qfaf084","url":null,"abstract":"<p><strong>Background: </strong>While research has shown that sexual dysfunction does not impact fertility, public understanding of this relationship remains unclear.</p><p><strong>Aim: </strong>To investigate the relationship between public cognition of the association between sexual dysfunction and fertility (ASDF) and the occurrence of sexual dysfunction itself.</p><p><strong>Methods: </strong>This cross-sectional study utilized a nationally representative sample of 10 761 reproductive-age individuals across China. Participants completed an anonymous questionnaire assessing sexual function and ASDF cognition, using tools like IIEF-5, PEDT, and FSFI-19. Data analysis was conducted with R software, employing χ² and Mann-Whitney <i>U</i> tests.</p><p><strong>Outcomes: </strong>The study identified a significant correlation between ASDF cognition and the severity of sexual dysfunction, with lower levels of cognition associated with more severe dysfunction.</p><p><strong>Results: </strong>Among 10 761 surveyed, 45.08% of men and 54.92% of women showed low ASDF cognition. There was a significant correlation between ASDF cognition and sexual dysfunction severity, with poor cognition associated with more severe ED and PE in men, and sexual intercourse pain in women.</p><p><strong>Clinical implications: </strong>The findings suggest the need for targeted sexual health education to improve public understanding of sexual dysfunction and its impact on fertility.</p><p><strong>Strengths and limitations: </strong>Strengths include a large nationally representative sample and the use of validated tools. Limitations are the China-focused sample and subjective assessment tools, which may limit broader applicability.</p><p><strong>Conclusion: </strong>This study identifies a significant association between ASDF cognition and the severity of sexual dysfunction, underscoring the importance of public education on sexual health.</p>","PeriodicalId":21782,"journal":{"name":"Sexual Medicine","volume":"13 5","pages":"qfaf084"},"PeriodicalIF":2.4,"publicationDate":"2025-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12560785/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145401748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preliminary psychometric linguistic validation of the satisfaction survey for inflatable penile implant in Spanish.","authors":"Jose M Flores, Bernardita M Ljubetic, Luis F Novaes, Edgardo F Becher, Ignacio Alvarez de Toledo, Alejandro Carvajal, Esteban Calle Correa, Esau Fernandez-Pascual, Juan Ignacio Martinez-Salamanca, Christian Nelson, Carolyn A Salter, Jose Torremade, Maurizio D'Anna, Robert Valenzuela, Alexander Negron, Sergio Moreno, Cristóbal Henríquez, Thomas M Atkinson, John P Mulhall","doi":"10.1093/sexmed/qfaf089","DOIUrl":"10.1093/sexmed/qfaf089","url":null,"abstract":"<p><strong>Background: </strong>Despite attempts to assess patient satisfaction with inflatable penile prosthesis (IPP) among Spanish-speaking populations, the absence of a validated, purpose-specific questionnaire in Spanish remains a significant gap.</p><p><strong>Aim: </strong>This study aims to report the preliminary psychometric validation of Spanish Satisfaction Survey for Inflatable Penile Implant (SSIPI).</p><p><strong>Methods: </strong>Six centers were selected to represent diverse Spanish-speaking populations in Latin America, the United States, and Spain. It included men who had IPP surgery between 6 months and 5 years ago. The translation and cultural adaptation of the SSIPI from English to Spanish followed a systematic multi-staged approach. Each participant received 4 surveys: (i) the final Spanish SSIPI, (ii) the IIEF erectile function domain (IIEF-EFD), (iii) the Self-Esteem and Relationship (SEAR) questionnaire, and (iv) the International Prostate Symptom Score (IPSS). Reliability, internal consistency, and intraclass correlation were evaluated. A convergent analysis was also used to evaluate Spanish SSIPI with SEAR and IIEF-EFD and a divergent analysis between Spanish SSIPI and IPSS.</p><p><strong>Outcomes: </strong>Spanish SSIPI psychometric validation.</p><p><strong>Results: </strong>A total of 111 participants were enrolled in the study. The median age was 64. The majority of participants (87%) were partnered, with a median relationship duration of 96 months. The median partner age was 56. Self-reported median time since IPP implantation was 21 months, with individuals indicating that they use the implant with a median of 5 times per month. Inflatable penile prosthesis satisfaction was generally high across all domains. Spanish SSIPI showed good reliability, high consistency, and high internal reliability across all SSIPI domains. Spanish SSIPI domains had significant correlations with the IIEF-EFD and SEAR. Spanish SSIPI domains were not significantly correlated with the overall IPSS score.</p><p><strong>Clinical implications: </strong>Spanish SSIPI is a linguistically, culturally, and psychometrically validated patient-reported outcomes measure of satisfaction with IPP, facilitating cross-comparative analysis with previously validated English and French versions.</p><p><strong>Strengths and limitations: </strong>This study demonstrates several methodological strengths, including applying a comprehensive psychometric approach, validating across multiple centers, and using a solid methodology to validate Spanish SSIPI. However, there are limitations, particularly the underrepresentation of specific subpopulations and the omission of pre-operative erectile function assessment.</p><p><strong>Conclusion: </strong>The preliminary Spanish SSIPI demonstrated robust reliability and internal consistency across diverse Spanish-speaking regions.</p>","PeriodicalId":21782,"journal":{"name":"Sexual Medicine","volume":"13 5","pages":"qfaf089"},"PeriodicalIF":2.4,"publicationDate":"2025-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12554161/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145378427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The basis for self-reported sexual dysfunction and the diagnostic value of masturbation-related parameters in men who have not engaged in vaginal intercourse in the past 6 months or have never engaged in it: a comparative study.","authors":"Zhihui Mao, Juanhui Ye, Karl H Pang, Chunlin Wang, Yan Zhang","doi":"10.1093/sexmed/qfaf087","DOIUrl":"10.1093/sexmed/qfaf087","url":null,"abstract":"<p><strong>Background: </strong>Men who have not engaged in vaginal intercourse in the past 6 months or have never engaged in it often seek help for sexual dysfunction, identifying factors influencing patients' self-assessment of sexual function and the value of masturbation-related parameters in diagnosing sexual dysfunction is of great importance.</p><p><strong>Aim: </strong>This study aims to understand the reason why patients self-report sexual dysfunction and evaluate the role of masturbation parameters in diagnosing sexual dysfunction in self-reported sexual dysfunction (SRSD) and self-reported no sexual dysfunction (SRNSD) groups.</p><p><strong>Methods: </strong>Our study was conducted mainly by filling out a questionnaire, which collected demographic information, sexual history as well as sexual parameters. The questionnaire summarized the basis of patients' self-reported sexual dysfunction and also included the Erection Hardness Score (EHS), Masturbation Erection Index (MEI), Masturbatory Premature Ejaculation Diagnostic Tool (MPEDT), and masturbatory ejaculation latency time (MELT).</p><p><strong>Outcomes: </strong>The main outcomes were reasons for SRSD individuals to judge their sexual dysfunction, the EHS, MEI, MPEDT, and MELT scores.</p><p><strong>Results: </strong>The most common complaints included insufficient erection hardness and short ejaculation latency time during masturbation, with 84.85% of self-reported erectile dysfunction and 91.80% of self-reported premature ejaculation patients reporting these issues. No significant difference was found between past vaginal sexual experiences (6 months ago) and current self-reported sexual dysfunction. Significant differences were found in EHS, MEI, MPEDT, and MELT scores between the SRSD and SRNSD groups. The MEI showed a sensitivity of 89.29% and a specificity of 81.82%. The MPEDT demonstrated a sensitivity of 98.04% and a specificity of 72.73%.</p><p><strong>Clinical implications: </strong>We proposed that other than vaginal intercourse, sexual dysfunction should also be assessed from noncoital sex and verified the scientific validity of the masturbation parameters in people without recent vaginal intercourse.</p><p><strong>Strengths & limitations: </strong>We firstly explored the patients self-perceived basis for sexual dysfunction. However, the objective instruments were not employed in diagnosing sexual dysfunction.</p><p><strong>Conclusion: </strong>The findings emphasize the importance of a comprehensive clinical assessment that includes evaluating masturbation, noncoital sex (between men and women), morning erections, and past vaginal sexual experiences (6 months ago), moreover, masturbatory scales provide valuable insights in diagnosing sexual dysfunction.</p>","PeriodicalId":21782,"journal":{"name":"Sexual Medicine","volume":"13 5","pages":"qfaf087"},"PeriodicalIF":2.4,"publicationDate":"2025-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12554156/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145378425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Abnormal grey matter in identifying primary intravaginal anejaculation patients from healthy controls: a voxel-based morphometry analysis.","authors":"Qingqiang Gao, Heng Wang, Youfeng Han, Jiaming Lu, Peining Niu, Jianhuai Chen","doi":"10.1093/sexmed/qfaf086","DOIUrl":"10.1093/sexmed/qfaf086","url":null,"abstract":"<p><strong>Introduction: </strong>Abnormal spontaneous neural activity has been detected in the brain of anejaculation patients. It has been confirmed that anejaculation may be associated with altered regional activation in the brain.</p><p><strong>Aim: </strong>This study aimed to explore the changes of grey matter in the brain of anejaculation patients.</p><p><strong>Methods: </strong>Structural magnetic resonance imaging data were collected from 20 primary intravaginal anejaculation (PIAJ) patients and 16 matched healthy controls (HCs). The 3D high resolution T1 weighted images were processed to calculate the grey matter volume and density by the method of voxel-based morphometry analysis.</p><p><strong>Outcomes: </strong>Differences of grey matter volume and density were compared between groups, and receiver operating characteristic curve was performed to evaluate the values of altered brain regions in distinguishing PIAJ from HCs.</p><p><strong>Results: </strong>PIAJ patients showed increased grey matter volume in the right supplementary motor area, right inferior temporal gyrus, right superior and inferior occipital gyrus, part of the left precuneus and decreased grey matter grey matter in another part of the left precuneus. In addition, increased grey matter density of the right supplementary motor area, right postcentral gyrus, right inferior temporal gyrus, left middle frontal gyrus, left inferior temporal gyrus and decreased grey matter density of the left precuneus were revealed in PIAJ patients. Both abnormal grey matter volume and altered grey matter density exhibited satisfactory performance in distinguishing PIAJ from HCs.</p><p><strong>Clinical implications: </strong>These findings suggested that increased microstructural changes of grey matter might be associated with the increased inhibiting effect of the brain on ejaculation.</p><p><strong>Strengths & limitations: </strong>This study provided new insights into the pathological mechanism underlying PIAJ, These findings are exploratory and that future longitudinal or comparative studies (eg, PIAJ vs. premature ejaculation) will be necessary to clarify whether these changes are predisposing, consequential, or potentially modifiable.</p><p><strong>Conclusion: </strong>These findings indicated that patients suffering from PIAJ might exhibit abnormal grey matter volume and density in some brain regions, which might be linked to the inability to ejaculate intravaginally. PIAJ patient showed more increased indicators of grey matter when compared with premature ejaculation patients, which often had decreased brain function.</p>","PeriodicalId":21782,"journal":{"name":"Sexual Medicine","volume":"13 5","pages":"qfaf086"},"PeriodicalIF":2.4,"publicationDate":"2025-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12554162/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145378477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A cross-species multi-omics analyze uncovers conserved molecular mechanisms underlying age-related erectile dysfunction.","authors":"Qing Long, Yuanhua Jiang, Jun Zhou, Jingxuan Peng","doi":"10.1093/sexmed/qfaf078","DOIUrl":"10.1093/sexmed/qfaf078","url":null,"abstract":"<p><strong>Background: </strong>The urgent need for new treatments is driven by the challenging clinical situation of age-related erectile dysfunction (ARED).</p><p><strong>Aim: </strong>To clarify the conserved molecular mechanisms of ARED across species using multi-omics.</p><p><strong>Methods: </strong>Rat and mouse models with ARED were developed to facilitate the extraction of mRNA and proteins from the corpus cavernosum for high-throughput sequencing. Bioinformatics techniques were employed to analyze differentially expressed genes and to conduct analyses using the Kyoto Encyclopedia of Genes and Genomes, Gene Ontology, and protein-protein interaction networks. Verification of the results was carried out using immunofluorescence, hematoxylin-eosin staining, and Masson staining.</p><p><strong>Outcomes: </strong>The multi-omics profiles of ARED rats and mice were analyzed and validated across species.</p><p><strong>Results: </strong>In both species, Kyoto Encyclopedia of Genes and Genomes and Gene Ontology analyses of transcriptomic and proteomic data revealed that differentially expressed genes were predominantly enriched in pathways associated with alterations in extracellular matrix composition, downregulation of mitochondrial activity, and disruption of protein homeostasis. Immunofluorescence analysis demonstrated an upregulation of reactive oxygen species expression, coupled with a downregulation of Aldh18a1, collagen, and collagen I expression in the corpus cavernosum of mice and rats with ARED.</p><p><strong>Clinical implications: </strong>To offer a novel approach for enhancing the erectile function in patients with ARED.</p><p><strong>Strengths and limitations: </strong>The primary strength of this study lies in its utilization of cross-species multi-omics sequencing, which has elucidated the conserved molecular mechanisms underlying ARED. However, a significant limitation is the absence of subsequent validation in patients with ARED.</p><p><strong>Conclusions: </strong>Cross-species multi-omics comparisons present a potentially innovative approach for elucidating the underlying mechanisms and identifying preventive and therapeutic targets for ARED.</p>","PeriodicalId":21782,"journal":{"name":"Sexual Medicine","volume":"13 5","pages":"qfaf078"},"PeriodicalIF":2.4,"publicationDate":"2025-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12531994/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145329875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}