Sexual Medicine最新文献

{"title":"Sexual experiences and information needs among patients with prostate cancer: a qualitative study","authors":"Haining Zhou, Xiaoli Zhang, Jiping Zhu, Beibei Zhang, Meng Ping, Yunfei Guo","doi":"10.1093/sexmed/qfae019","DOIUrl":"https://doi.org/10.1093/sexmed/qfae019","url":null,"abstract":"Abstract Background Less is known about the sexual life and information seeking of Chinese patients with prostate cancer (PCa) after androgen deprivation therapy (ADT) treatment. Aim To identify the experiences of sex and information needs among Chinese patients with PCa after ADT treatment. Methods This qualitative study included 15 Chinese patients with PCa in urology inpatient wards, selected via a purposive sampling method. Semistructured interviews were conducted face-to-face or by telephone regarding sexual experiences and information needs after ADT treatment. Outcomes Themes and subthemes were assessed among patients with PCa. Results Two themes and 5 subthemes emerged from the interview data. The first theme was “altered sexual life and attitude” with 3 subthemes: (1) undesirable sexual function and altered sexuality, (2) sexual attitudes and sociocultural cognition, and (3) behavior adjustment and intimacy. The second theme was “scarce information sources” with 2 subthemes: (1) uncertainty and lack of information support and (2) barriers to access sexual information. Clinical Implications The present findings suggest that the following may help patients with PCa manage treatment and develop appropriate sexual attitudes: a tailored sexual health education program, well-equipped consultations rooms, and information delivery innovations. Strengths and Limitations Strengths of this study included adding unique evidence among patients with PCa within an Asian context to reveal the understudied topic of sexual health and information needs after ADT treatment. This study was limited in being representative of all Chinese patients with PCa, with different marital statuses, treatment therapies, sexual orientations, and barriers of information seeking. Conclusion Sexual life and attitude among patients with PCa were affected by their sociocultural cognition and ADT treatment, and most patients received insufficient information and sexual health education from health care providers.","PeriodicalId":21782,"journal":{"name":"Sexual Medicine","volume":"81 ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140786508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sexual health among the oldest old: a population-based study among people aged 85 years and older in Stockholm, Sweden","authors":"Marios Politis, K. Kosidou, Stefan Fors, Martina Nord","doi":"10.1093/sexmed/qfae022","DOIUrl":"https://doi.org/10.1093/sexmed/qfae022","url":null,"abstract":"Abstract Background Sexual health is an important contributor to the well-being and life satisfaction of people aged ≥85 years, known as the oldest old. However, little is known about sexual health in this population. Aim To examine aspects of sexual health among the oldest old and explore its associations with sociodemographic, health-related, and lifestyle factors. Methods We conducted a population-based cross-sectional study including 183 individuals aged ≥85 years who were residents in Stockholm County, Sweden. Responders (response rate, 63%) were interviewed on a range of health, sociodemographic, and lifestyle parameters, including aspects of sexual health. Participants’ responses to the sexual health items were reported as proportions with 95% CIs. Associations were examined with multivariable logistic regression. Outcomes We examined sexual activity, sexual satisfaction, problems related to sexual health, and inquiries on sexual health by a health care provider. Results Twelve percent of participants (95% CI, 8%-17.6%) were sexually active, and 63.9% (95% CI, 56.5%-70.9%) were satisfied with their sexual lives during the past year. A third (35%; 95% CI, 28.4%-42.2%) reported at least a problem related to sexual health. Only 2.2% (95% CI, 0.6%-5.5%) were asked about sexual health by a health care provider, while 8.2% (95% CI, 4.7%-13.2%) identified a need for such an assessment. Yet, 85.2% (95% CI, 79.3%-90.0%) indicated no need for their sexual health to be evaluated by a health care provider. Being partnered was positively associated with sexual activity (adjusted odds ratio, 9.13; 95% CI, 2.53-32.90), whereas having strong social support was positively associated with being satisfied with one’s sexual life (adjusted odds ratio, 2.96; 95% CI, 1.53-5.74). Clinical Implications Health care providers should be proactive in assessing the sexual health of the oldest individuals. Strengths and Limitations A representative sample of an underresearched population was used in this study. However, the generalizability of our findings may be restricted due to the small sample. To maintain statistical power from a relatively small sample, we might have lost explanatory power. Given the observational cross-sectional nature of the data, we cannot draw causal inferences based on the observed associations. Conclusions A 10th of participants were sexually active, and the majority were satisfied with their sexual lives. Although many participants reported problems related to sexual health, few expressed the need to discuss sexual health with health care providers. Future studies should explore potential barriers to addressing sexual health and unmet health care needs among the oldest old.","PeriodicalId":21782,"journal":{"name":"Sexual Medicine","volume":"49 ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140770172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of sexual dysfunction in Chinese patients with schizophrenia: a systematic review and meta-analysis.","authors":"Linghui Zhang, Yubin Chen, Yujing Sun, Yuqiu Zhou, Qi Li, Yannan Jia","doi":"10.1093/sexmed/qfae009","DOIUrl":"10.1093/sexmed/qfae009","url":null,"abstract":"<p><strong>Background: </strong>There may be a higher risk of sexual dysfunction in the schizophrenia population. China has made significant contributions to the global community of patients with schizophrenia. Currently, there is no estimation of the prevalence of sexual dysfunction in Chinese patients with schizophrenia.</p><p><strong>Aim: </strong>We conducted a meta-analysis to pool the evaluated prevalence of sexual dysfunction in Chinese patients with schizophrenia.</p><p><strong>Methods: </strong>We systematically searched PubMed, Web of Science, Embase, PsycINFO, China National Knowledge Infrastructure, China Science and Technology Journal Database, Wanfang Medical Network, and Huayi Academic Literature Database from inception to September 2023. Meta-analysis was conducted with R version 4.3.1.</p><p><strong>Outcomes: </strong>To examine the pooled prevalence of sexual dysfunctions among Chinese patients with schizophrenia.</p><p><strong>Results: </strong>In our meta-analysis, we included 16 studies with 5417 participants, among whom 1727 experienced sexual dysfunction. The results of the meta-analysis reveal that the prevalence of sexual dysfunction in Chinese patients with schizophrenia is 50.43% (95% CI, 37.86%-62.95%). Subgroup analysis results indicate that various factors-including the specific type of dysfunction, duration of illness, assessment tools, mean ages, study region, gender, research setting, marital status, publication years, and type of antipsychotics-all have a particular impact on the occurrence rate of sexual dysfunction in Chinese patients with schizophrenia. Female patients had a slightly higher prevalence of sexual dysfunction than male patients (65.22% vs 54.84%).</p><p><strong>Clinical implications: </strong>The findings of this study can be used in high-quality nursing care for the schizophrenia population, particularly for the care of specific sexual dysfunction nursing.</p><p><strong>Strengths and limitations: </strong>This meta-analysis is the first to evaluate the prevalence of sexual dysfunction in China among patients with schizophrenia. The limited number of studies is the most important limitation.</p><p><strong>Conclusions: </strong>The pooled prevalence of sexual dysfunction in Chinese patients with schizophrenia is relatively high, and the prevention and intervention of individual sexual dysfunctions in schizophrenia are advised.</p>","PeriodicalId":21782,"journal":{"name":"Sexual Medicine","volume":"12 2","pages":"qfae009"},"PeriodicalIF":2.6,"publicationDate":"2024-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10982523/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140336826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and associated factors of premature ejaculation and erectile dysfunction in young, single men who have sex with men in Lima, Peru.","authors":"Anggie Stephany Santillán-Romero, Mario J Valladares-Garrido, Alejandro Juarez-Ubillus, Angie Giselle Morocho Alburqueque, Danai Valladares-Garrido, Víctor J Vera-Ponce, César J Pereira-Victorio, Darwin A León-Figueroa, J Antonio Grandez-Urbina","doi":"10.1093/sexmed/qfae013","DOIUrl":"10.1093/sexmed/qfae013","url":null,"abstract":"<p><strong>Background: </strong>While there is literature on erectile dysfunction (ED) and premature ejaculation (PE) in men, conclusive evidence regarding these sexual health issues and potential associated factors in the young, single men who have sex with men (MSM) population is lacking.</p><p><strong>Aim: </strong>The study sought to determine the prevalence and factors associated with PE and ED in young single MSM in the capital of Peru.</p><p><strong>Methods: </strong>This was an analytical cross-sectional study in MSM using an online questionnaire. The presence of ED and PE was assessed using the 5-item International Index of Erectile Function and 5-item Premature Ejaculation Diagnostic Tool questionnaires, respectively. In addition, their association with personal, physical health, and sexual behavior variables was evaluated. Prevalence ratios (PRs) were estimated through regression models.</p><p><strong>Outcomes: </strong>Premature ejaculation and Erectile dysfunction in MSM.</p><p><strong>Results: </strong>Of 315 participants, most were between 20 to 29 years of age (71.8%), 43.5% identified as homosexual, 59.1% had between 2 and 5 sexual partners, and 40.6% reported that the duration of their sexual relationship was between 1 and 12 months. The prevalence of ED was 53.3% (95% confidence interval [CI], 47.66%-58.95%), and PE was present in 8.3% (95% CI, 5.46%-11.86%). Factors associated with a higher prevalence of ED were having between 6 and 9 sexual partners (PR, 1.48; 95% CI, 1.05-2.11) and having a sexual relationship lasting 13 to 24 months (PR, 0.70; 95% CI, 0.50-0.98). Furthermore, for each additional year from the onset of the first sexual encounter with another man, the prevalence of PE increased by 7% (PR, 1.07; 95% CI, 1.02-1.13).</p><p><strong>Clinical implications: </strong>These findings suggest that there is a relationship between an increased number of sexual partners and a higher prevalence of ED. It also suggests that relationships that last for some time may have a protective effect against ED.</p><p><strong>Strengths and limitations: </strong>Strengths include the use of validated instruments, adequate sample size, robust multivariate analysis, and being one of the few studies in Latin America assessing PE and ED in the MSM population. Limitations include the cross-sectional design, nonprobability sampling, and access to participants.</p><p><strong>Conclusion: </strong>Having more sexual partners is associated with increased ED, while relationships lasting 13 to 24 months are associated with decreased ED. Each additional year from the onset of the first sexual relationship increases the prevalence of PE. These findings can guide the design of health policies and programs tailored to the MSM community to enhance their well-being and sexual quality of life.</p>","PeriodicalId":21782,"journal":{"name":"Sexual Medicine","volume":"12 2","pages":"qfae013"},"PeriodicalIF":2.6,"publicationDate":"2024-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10981762/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140336825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A survey of patient tolerance and satisfaction with capsaicin for neuroproliferative vestibulodynia.","authors":"Isabella Kopits, Jill M Krapf, Chailee Moss, Theodora Mautz, Jess Holloway, Lilliana Starsiak, Sylvia Lorenzini, Andrew T Goldstein","doi":"10.1093/sexmed/qfae012","DOIUrl":"10.1093/sexmed/qfae012","url":null,"abstract":"<p><strong>Background: </strong>Topical capsaicin has been used to treat vulvodynia but has been poorly studied for use in neuroproliferative provoked vestibulodynia (PVD); capsaicin decreases allodynia by blocking vanilloid receptors (TRPV1) on C-afferent nociceptors, but the therapy causes discomfort to the point of intolerance in some patients.</p><p><strong>Aim: </strong>The present study evaluated tolerability and efficacy of topical capsaicin to treat neuroproliferative PVD.</p><p><strong>Methods: </strong>Patients with neuroproliferative PVD prescribed 0.025% capsaicin compounded in VersaBase cream were identified through prescription records. Outcome measures included the Female Sexual Function Index (FSFI), the Female Sexual Distress Scale-Revised, and a 22-question questionnaire assessing patient experience and treatment tolerability.</p><p><strong>Outcomes: </strong>Among tolerant patients, capsaicin significantly decreased vestibular pain, but tolerance was highly variable.</p><p><strong>Results: </strong>Twenty-five patients responded to the follow-up questionnaire. The average age at presentation was 30 years (range, 18-52 years). Eighty percent of patients tolerated capsaicin application for the full 20 minutes within a median time of 1 to 2 weeks. Of the 16 patients reporting tolerance to 20-minute application, 12 (60%) experienced improvement in vestibular pain. On an 11-point numeric rating scale, the mean pain score was 8.96 and the median score was 10 with first application. Among all participants, 16 (64%) had reduction in pain during treatment. Fifty-six percent of patients would recommend capsaicin as a treatment for vulvar pain. Qualitative content analysis focused on categories of efficacy, value, and feasibility, which indicated that those able to tolerate the treatment experienced improvement while using the medication. The mean Female Sexual Distress Scale-Revised score was 35.96 at baseline compared with 25.09 at follow-up (<i>P</i> < .0001). On a numeric rating scale, the mean self-reported vulvar pain score was 8.2 at baseline compared with 5.35 when using capsaicin consistently (<i>P</i> < .0001). The mean FSFI pain domain score was 2.45 at baseline compared with 0.98 at follow-up (<i>P</i> = .005). While not statistically significant, the mean total FSFI score was 15.44 at baseline compared with 17.84 at follow-up (<i>P</i> = .3730).</p><p><strong>Clinical implications: </strong>Capsaicin is helpful for some patients with PVD, but thorough counseling is important because of highly variable tolerance.</p><p><strong>Strengths and limitations: </strong>Strengths include examination of a poorly studied therapy and inclusion of narrative responses from patients to inform counseling. Limitations include small sample size, retrospective design, and low survey response rate.</p><p><strong>Conclusion: </strong>Patients should be appropriately selected and thoroughly counseled given high levels of intolerance, but capsaicin","PeriodicalId":21782,"journal":{"name":"Sexual Medicine","volume":"12 1","pages":"qfae012"},"PeriodicalIF":2.6,"publicationDate":"2024-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10971571/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140306870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beneficial effects of the first case of washed microbiota transplantation for postorgasmic illness syndrome: a case report.","authors":"Yong-Xi Quan, Ye-Dong Lao, Hui-Yi Wu, Xing-Xiang He, Li-Hao Wu","doi":"10.1093/sexmed/qfae015","DOIUrl":"10.1093/sexmed/qfae015","url":null,"abstract":"<p><strong>Introduction: </strong>Postorgasmic illness syndrome (POIS) is characterized by allergic symptoms and flu-like illness after ejaculation. There are still no effective treatments for POIS.</p><p><strong>Aim: </strong>To report the first case of washed microbiota transplantation (WMT) to treat patient with POIS.</p><p><strong>Methods: </strong>Data were collected from a patient with POIS who had received 3 courses of WMT: self-rating scale of POIS symptoms, Self-rating Anxiety Scale, Self-rating Depression Scale, and Symptom Checklist 90. The patient's stool samples for 16sDNA sequencing were collected 1 month after WMT.</p><p><strong>Results: </strong>POIS symptoms improved after WMT. Scores decreased from baseline after WMT: self-rating scale of POIS symptoms (before WMT, 16; after first, 16; after second, 8; after third, 9), Self-rating Anxiety Scale (45, 42.5, 37.5, 45), Self-rating Depression Scale (63.75, 58.75, 47.5, 50), and Symptom Checklist 90 (143, 140, 109, 149). Characteristics of the patient's gut microbiota changed. At the genus level, the relative abundance of beneficial bacteria increased, and some opportunistic pathogenic bacteria decreased.</p><p><strong>Conclusion: </strong>WMT may be an effective and safe choice for the treatment of patients with POIS by changing the gut microbiota of the host.</p>","PeriodicalId":21782,"journal":{"name":"Sexual Medicine","volume":"12 2","pages":"qfae015"},"PeriodicalIF":2.6,"publicationDate":"2024-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10973931/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140336822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Illegal products containing selective androgen receptor modulators purchased online from Italy: health risks for consumers.","authors":"Maria Cristina Gaudiano, Federica Aureli, Livia Manna, Anna Borioni, Alessandro Maccelli, Mariangela Raimondo, Donato De Giorgi, Monica Bartolomei","doi":"10.1093/sexmed/qfae018","DOIUrl":"10.1093/sexmed/qfae018","url":null,"abstract":"<p><strong>Background: </strong>Selective androgen receptor modulators (SARMs) are small synthetic drug molecules that are still not approved as medicine in Europe or the United States but are sold on illegal websites to improve sport performance, particularly bodybuilding.</p><p><strong>Aim: </strong>To address the quality issues of illegal SARM products and their increasing diffusion in Italy with their potential health risks for consumers.</p><p><strong>Methods: </strong>Web-based tools were used to investigate retail websites, trending searches, and information exchange via social media. Thirteen SARM products, purchased on retail websites accessible from Italy, were subject to visual inspection and chemical analysis by mass spectrometry and quantitative nuclear magnetic resonance.</p><p><strong>Outcomes: </strong>The primary outcome was demonstration of additional health risks due to the illicit presence of other active ingredients, contamination, and misdosage in SARM products sold on the internet. The secondary outcome was to show the increasing trend of interest in Italy for these products.</p><p><strong>Results: </strong>Most websites reported misleading information; specifically, the statement \"for research only\" was reported notwithstanding indications on dosage and training phases. The trending search showed that interest toward SARMs increased in Italy in the last years. The use of these products is clearly encouraged by the emerging phenomenon of \"broscience\" as revealed in socials. Visual inspection evidenced nonconform labeling. Qualitative analysis confirmed the presence of the stated SARM in about 70% of samples. In 23% of samples, the expected SARM was not detected but a different one instead, and in 1 sample, no SARMs were detected. Other undeclared pharmaceutical substances (tamoxifen, clomifene, testosterone, epimethandienone, tadalafil) were measured in 30% of samples. The copresence of >1 active substance was observed in >60% of samples. Quantitative nuclear magnetic resonance data showed nonuniform content ranging from 30% to 90% of the label claim.</p><p><strong>Clinical implications: </strong>The use of SARMs, in the presence of unexpected life-threatening reactions in persons using the products to increase sport performance, should be assessed.</p><p><strong>Strengths and limitations: </strong>This investigation involved an integrated approach to study SARM products and related sociologic aspects. The main shortcomings are the limited number of samples and retail websites in the clear web investigated.</p><p><strong>Conclusion: </strong>SARMs sold online as food supplement-like products represent a health hazard due to the presence of unapproved and undeclared active substances. The presence of contaminants clearly indicates the absence of good manufacturing practices in the production, which increases the health risks.</p>","PeriodicalId":21782,"journal":{"name":"Sexual Medicine","volume":"12 2","pages":"qfae018"},"PeriodicalIF":2.6,"publicationDate":"2024-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10973938/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140336823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimizing trial design in studies of postorgasmic illness syndrome.","authors":"Alan W Shindel","doi":"10.1093/sexmed/qfae016","DOIUrl":"10.1093/sexmed/qfae016","url":null,"abstract":"","PeriodicalId":21782,"journal":{"name":"Sexual Medicine","volume":"12 2","pages":"qfae016"},"PeriodicalIF":2.6,"publicationDate":"2024-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10973934/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140336824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification and validation of new fatty acid metabolism-related mechanisms and biomarkers for erectile dysfunction.","authors":"Yanfeng He, Changyi Liu, Zhongjie Zheng, Rui Gao, Haocheng Lin, Huiliang Zhou","doi":"10.1093/sexmed/qfae011","DOIUrl":"10.1093/sexmed/qfae011","url":null,"abstract":"<p><strong>Background: </strong>Erectile dysfunction (ED) is a common condition affecting middle-aged and elderly men.</p><p><strong>Aim: </strong>The study sought to investigate differentially expressed fatty acid metabolism-related genes and the molecular mechanisms of ED.</p><p><strong>Methods: </strong>The expression profiles of GSE2457 and GSE31247 were downloaded from the Gene Expression Omnibus database and merged. Differentially expressed genes (DEGs) between ED and normal samples were obtained using the R package limma. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analyses of DEGs were conducted using the R package clusterProfiler. Fatty acid metabolism-related DEGs (FAMDEGs) were further identified and analyzed. Machine learning algorithms, including Lasso (least absolute shrinkage and selection operator), support vector machine, and random forest algorithms, were utilized to identify hub FAMDEGs with the ability to predict ED occurrence. Coexpression analysis and gene set enrichment analysis of hub FAMDEGs were performed.</p><p><strong>Outcome: </strong>Fatty acid metabolism-related functions (such as fatty acid metabolism and degradation) may play a vital role in ED.</p><p><strong>Results: </strong>In total, 5 hub FAMDEGs (<i>Aldh2</i>, <i>Eci2</i>, <i>Acat1</i>, <i>Acadl</i>, and <i>Hadha</i>) were identified and found to be differentially expressed between ED and normal samples. Gene set enrichment analysis identified key pathways associated with these genes. The area under the curve values of the 5 hub FAMDEGs for predicting ED occurrence were all >0.8.</p><p><strong>Clinical translation: </strong>Our results suggest that these 5 key FAMDEGs may serve as biomarkers for the diagnosis and treatment of ED.</p><p><strong>Strengths and limitations: </strong>The strengths of our study include the use of multiple datasets and machine learning algorithms to identify key FAMDEGs. However, limitations include the lack of validation in animal models and human tissues, as well as research on the mechanisms of these FAMDEGs.</p><p><strong>Conclusion: </strong>Five hub FAMDEGs were identified as potential biomarkers for ED progression. Our work may prove that fatty acid metabolism-related genes are worth further investigation in ED.</p>","PeriodicalId":21782,"journal":{"name":"Sexual Medicine","volume":"12 1","pages":"qfae011"},"PeriodicalIF":2.6,"publicationDate":"2024-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10960936/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140288907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genetic prediction of modifiable lifestyle factors for erectile dysfunction.","authors":"Yu-Jia Xi, Yi-Ge Feng, Ya-Qi Bai, Rui Wen, He-Yi Zhang, Qin-Yi Su, Qiang Guo, Cheng-Yong Li, Zhen-Xing Wang, Liang Pei, Sheng-Xiao Zhang, Jing-Qi Wang","doi":"10.1093/sexmed/qfae010","DOIUrl":"https://doi.org/10.1093/sexmed/qfae010","url":null,"abstract":"<p><strong>Background: </strong>The causal relationship between certain lifestyle factors and erectile dysfunction (ED) is still uncertain.</p><p><strong>Aim: </strong>The study sought to investigate the causal effect of 9 life factors on ED through 2-sample single-variable Mendelian randomization (SVMR) and multivariable Mendelian randomization (MVMR).</p><p><strong>Methods: </strong>Genetic instruments to proxy 9 risk factors were identified by genome-wide association studies. The genome-wide association studies estimated the connection of these genetic variants with ED risk (n = 223 805). We conducted SVMR, inverse variance-weighting, Cochran's Q, weighted median, MR-Egger, MR-PRESSO (Mendelian Randomization Pleiotropy RESidual Sum and Outlier), and MVMR analyses to explore the total and direct relationship between life factors and ED.</p><p><strong>Outcomes: </strong>The primary outcome was defined as self or physician-reported ED, or using oral ED medication, or a history of surgery related to ED.</p><p><strong>Results: </strong>In SVMR analyses, suggestive associations with increased the risk of ED were noted for ever smoked (odds ratio [OR], 5.894; 95% confidence interval [CI], 0.469 to 3.079; <i>P</i> = .008), alcohol consumption (OR, 1.495; 95% CI, 0.044 to 0.760; <i>P</i> = .028) and body mass index (BMI) (OR, 1.177; 95% CI, 0.057 to 0.268; <i>P</i> = .003). Earlier age at first intercourse was significantly related to reduced ED risk (OR, 0.659; 95% CI, -0.592 to -0.244; <i>P</i> = 2.5 × 10^-6). No strong evidence was found for the effect of coffee intake, time spent driving, physical activity, and leisure sedentary behaviors on the incidence of ED (All <i>P</i> > .05). The result of MVMR analysis for BMI (OR, 1.13; 95% CI, 1.01 to 1.25; <i>P</i> = .045) and earlier age at first intercourse (OR, 0.77; 95% CI, 0.56 to 0.99; <i>P</i> = .018) provided suggestive evidence for the direct impact on ED, while no causal factor was detected for alcoholic drinks per week and ever smoked.</p><p><strong>Clinical implications: </strong>This study provides evidence for the impact of certain modifiable lifestyle factors on the development of ED.</p><p><strong>Strengths and limitations: </strong>We performed both SVMR and MVMR to strengthen the causal relationship between exposures and outcomes. However, the population in this study was limited to European ancestry.</p><p><strong>Conclusion: </strong>Ever smoked, alcoholic drinks per week, BMI, and age first had sexual intercourse were causally related to ED, while the potential connection between coffee intake, physical activity, recreational sedentary habits, and increased risk of ED needs to be further confirmed.</p>","PeriodicalId":21782,"journal":{"name":"Sexual Medicine","volume":"12 1","pages":"qfae010"},"PeriodicalIF":2.6,"publicationDate":"2024-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10949036/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140176328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}