Sexual Medicine最新文献

{"title":"The risk of sexual dysfunction in Chinese women with recurrent pregnancy loss and the associated factors: a multicenter cross-sectional study.","authors":"Chuanjiao Liu, Yiduo Zhang, Qian Xu, Chen Yang, Yuanting Tang, Qiong Zhang, Xiumei Liu, Yangang Yue, Fan Yu","doi":"10.1093/sexmed/qfae031","DOIUrl":"10.1093/sexmed/qfae031","url":null,"abstract":"<p><strong>Background: </strong>Recurrent pregnancy loss (RPL) is a severe traumatic event for women of childbearing age. However, the association between RPL and female sexual dysfunction was unknown.</p><p><strong>Aim: </strong>The study sought to investigate the association between RPL and sexual dysfunction, and to explore the risk factors of sexual dysfunction for RPL patients.</p><p><strong>Methods: </strong>A multicenter cross-sectional study involving both RPL patients and healthy women was performed in 3 different hospitals in West China from May 2021 to January 2023. Baseline information including sociodemographic data and disease histories were collected. The Female Sexual Function Index (FSFI) was used to assess the sexual function of participants.</p><p><strong>Outcomes: </strong>The main outcome was the proportion of women at increased risk of sexual dysfunction (total FSFI scores <26.55), and the secondary outcome was risk factors of sexual dysfunction in RPL patients.</p><p><strong>Results: </strong>A total of 233 RPL patients and 185 healthy women were included in this study. RPL patients had significantly lower total FSFI scores (median 31.7 [interquartile range, 26.6-33.5] vs 33.0 [interquartile range, 31.2-34.1]; <i>P <</i> .001) and a significantly higher risk of sexual dysfunction than healthy women (24.9% vs 8.6%; <i>P <</i> .001). Body mass index >24 kg/m² (adjusted odds ratio [OR], 4.132; 95% confidence interval [CI], 1.902-8.976, <i>P <</i> .001), working >8 h/d (adjusted OR, 2.111; 95% CI, 1.020-4.369, <i>P =</i> .044), and unexplained RPL (adjusted OR, 3.785; 95% CI, 1.967-7.280, <i>P <</i> .001) were independent risk factors of sexual dysfunction for RPL patients.</p><p><strong>Clinical implications: </strong>RPL patients, especially those patients with the previously mentioned risk factors, should be focused on the risk of sexual dysfunction, and appropriate preventions could be applied.</p><p><strong>Strength and limitations: </strong>We explored the association between RPL and sexual dysfunction and explored the risk factors of sexual dysfunction among RPL patients for the first time, and the multicenter data increased the generalizability of results. However, the cross-sectional design did not provide an exact causal relationship between RPL and sexual dysfunction, and potential risk factors related to mental health were not investigated.</p><p><strong>Conclusion: </strong>RPL patients were at an increased risk of sexual dysfunction. Overweight, fatigue caused by work, and unexplained RPL were risk factors of sexual dysfunction for RPL patients.</p>","PeriodicalId":21782,"journal":{"name":"Sexual Medicine","volume":"12 2","pages":"qfae031"},"PeriodicalIF":2.6,"publicationDate":"2024-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11128721/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141158487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ovotesticular disorder of sexual development manifested as hematospermia: a case report and literature review.","authors":"Chengdong Shi, Yuxiong Wang, Guoqiang Zeng, Hongliang Cao, Mo Chen, Yuantao Wang","doi":"10.1093/sexmed/qfae026","DOIUrl":"10.1093/sexmed/qfae026","url":null,"abstract":"<p><strong>Background: </strong>Ovotesticular disorder of sexual development (OT-DSD) is a rare sexual development disorder defined by the simultaneous existence of testicular and ovarian tissues (including follicular) in the same- or opposite-sex glands of an individual, with an incidence rate of about 1 in 100 000.</p><p><strong>Aim: </strong>This report aims to supplement the clinical presentation, pathology, diagnosis, and treatment of OT-DSD and to improve the diagnostic ability of clinicians for modified disease.</p><p><strong>Methods: </strong>This article is a retrospective analysis of a case of OT-DSD at our institution. Additionally, a comprehensive search of the PubMed database with the keywords \"ovotesticular disorder of sexual development\" or \"true hermaphroditism\" was conducted between 1956 and 2024, resulting in approximately 250 cases, and the results of the search are summarized.</p><p><strong>Results: </strong>The patient, a 44-year-old male, sought treatment at our hospital on February 6, 2023, primarily due to \"intermittent hematospermia for over a month.\" He stated that it was discovered during infancy that his right scrotum was empty and lacking a testicle. Due to the low local medical services and the low-income family's economic conditions, he did not seek further diagnosis and treatment. After admission, the patient underwent computed tomography and magnetic resonance imaging and decided to undergo robot-assisted pelvic mass resection, which was pathologically confirmed as OT-DSD.</p><p><strong>Outcomes: </strong>The patient's definitive diagnosis was provided by postoperative pathology, and although the patient ultimately had a favorable outcome, diagnosis and treatment were delayed due to his atypical clinical presentation.</p><p><strong>Strengths and limitations: </strong>This is a single case report; however, uncommon clinical presentations of rare diseases were identified, and a literature review was conducted. Unfortunately, there are some important missing data in the patient's medical history, including hormone assessment (testosterone, luteinizing hormone, follicle-stimulating hormone), tumor marker examination, semen analysis, scrotal ultrasound, and chromosomal analysis.</p><p><strong>Conclusion: </strong>Patients with OT-DSD have diverse types of gonads, chromosomal karyotypes, and phenotypes of external genitalia, and further exploration and research are needed for early diagnosis and treatment. In addition, cases of OT-DSD with fertility and no ambiguous genitalia are even rarer. This case guides us for adult patients with no ambiguous genitalia: if there is an inability to palpate 1 or both gonads and there is intermittent hematospermia, the possibility of OT-DSD should be suspected.</p>","PeriodicalId":21782,"journal":{"name":"Sexual Medicine","volume":"12 2","pages":"qfae026"},"PeriodicalIF":2.6,"publicationDate":"2024-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11307195/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141907660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to: The effect of local anesthetic on the hypersensitive and nonsensitive areas of the penis is different in primary premature ejaculation: a pilot study.","authors":"","doi":"10.1093/sexmed/qfae037","DOIUrl":"https://doi.org/10.1093/sexmed/qfae037","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.1093/sexmed/qfae020.].</p>","PeriodicalId":21782,"journal":{"name":"Sexual Medicine","volume":"12 2","pages":"qfae037"},"PeriodicalIF":2.6,"publicationDate":"2024-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11100258/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141066081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to: Translation, adaptation, and clinical validation of the Premature Ejaculation Diagnostic Tool in Spanish (Colombia).","authors":"","doi":"10.1093/sexmed/qfae032","DOIUrl":"https://doi.org/10.1093/sexmed/qfae032","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.1093/sexmed/qfac017.].</p>","PeriodicalId":21782,"journal":{"name":"Sexual Medicine","volume":"12 2","pages":"qfae032"},"PeriodicalIF":2.6,"publicationDate":"2024-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11101756/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141066082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pelvic floor disorders and impact on sexual function: a cross-sectional study among non-sexually active and sexually active women.","authors":"Signe Nilssen Stafne, Silje Kristine Sveen Ulven, Tone Prøsch-Bilden, Susan Saga","doi":"10.1093/sexmed/qfae024","DOIUrl":"10.1093/sexmed/qfae024","url":null,"abstract":"<p><strong>Background: </strong>Pelvic floor disorders are common and associated with impaired sexual function in women.</p><p><strong>Aim: </strong>To assess women with pelvic floor disorders and describe factors associated with not being sexually active and those associated with sexual function in sexually active women.</p><p><strong>Methods: </strong>A cross-sectional study was conducted that included nonpregnant women with symptoms of pelvic floor disorders who were referred to the urogynecologic and surgical outpatient clinic at 2 Norwegian university hospitals: St Olavs Hospital, Trondheim University Hospital, and the University Hospital of Northern Norway, Tromsø. Women answered a questionnaire anonymously.</p><p><strong>Outcomes: </strong>Pelvic Organ Prolapse Incontinence Sexual Questionnaire-IUGA Revised.</p><p><strong>Results: </strong>Of 157 respondents, 111 (71%) reported being sexually active (with or without a partner), and 46 (29%) reported not being sexually active. As compared with sexually active women, not sexually active women were older (mean ± SD, 60.2 ± 13.3 vs 51 ± 12.1 years; <i>P</i> < .001), more were menopausal (78% vs 47%, <i>P</i> = .001), and more had symptom debut <1 year (31% vs 9%, <i>P</i> < .001). They reported more distress related to pelvic floor disorders, especially pelvic organ prolapse. In a multivariate logistic regression analysis, menopausal women and women with symptom debut <1 year were 4 times more likely to be not sexually active than premenopausal women (odds ratio, 4.0; 95% CI, 1.7-9.2) and women with symptom debut ≥1 year (odds ratio, 4.0; 95% CI, 1.5-10.7). In sexually active women, colorectal-anal distress was negatively associated with 5 of 6 domains of sexual function: arousal/orgasm (ß = -0.36; 95% CI, -0.02 to -0.005), partner related (ß = -0.28; 95% CI, -0.01 to -0.002), condition specific (ß = -0.39; 95% CI, -0.002 to -0.009), global quality (ß = -0.23; 95% CI, -0.02 to -0.002), and condition impact (ß = -0.34; 95% CI, -0.02 to -0.006).</p><p><strong>Clinical implications: </strong>Health care professionals should discuss sexual function in patients with pelvic floor disorders, especially menopausal women and women with colorectal-anal symptoms.</p><p><strong>Strengths and limitations: </strong>The study used condition-specific measures and recruited women from 2 university hospitals with wide range of age. Limitations include the small sample size and wide confidence intervals. The number of women who considered themselves not sexually active was low, and item nonresponse levels among these women where somewhat high. Of 625 eligible women, 200 (32%) answered the questionnaire. Sexual health and sexual function are still surrounded with taboo, and some women were probably not comfortable answering the questions.</p><p><strong>Conclusion: </strong>Menopausal women and women with recent onset of symptoms of pelvic floor disorders are more likely to be sexually inactive, and colorectal-ana","PeriodicalId":21782,"journal":{"name":"Sexual Medicine","volume":"12 2","pages":"qfae024"},"PeriodicalIF":2.6,"publicationDate":"2024-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11079667/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140899679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Irritable bowel syndrome and erectile dysfunction in medical students at a Peruvian university: an analytical cross-sectional analysis.","authors":"Mario J Valladares-Garrido, Luis E Zapata-Castro, Pedro P Quiroga-Castañeda, Iván Berrios-Villegas, Víctor J Vera-Ponce, Darwin A León-Figueroa, César J Pereira-Victorio, Danai Valladares-Garrido","doi":"10.1093/sexmed/qfae021","DOIUrl":"10.1093/sexmed/qfae021","url":null,"abstract":"<p><strong>Background: </strong>There is inconclusive evidence regarding the role of irritable bowel syndrome (IBS) in the development of erectile dysfunction (ED), especially among medical students due to high academic stress.</p><p><strong>Aim: </strong>To determine the association between IBS and ED in medical students from a Peruvian university in 2022.</p><p><strong>Methods: </strong>An analytical cross-sectional study was conducted with secondary data analysis on 133 medical students from a university in northern Peru during the 2021-II academic semester. The dependent variable was ED as measured with the 5-item International Index of Erectile Function, and the exposure variable was IBS as assessed with the Rome IV-Bristol questionnaire.</p><p><strong>Outcomes: </strong>The results were the prevalence rates of IBS and ED and the association of these variables.</p><p><strong>Results: </strong>Of the 133 medical students surveyed, the median age was 22 years (IQR, 19-24). The median score on the 5-item International Index of Erectile Function was 21 (IQR, 10-24). The prevalence of ED was 38.4% (95% CI, 30.05%-47.17%). Among the medical students 3% and 9% displayed moderate and severe ED, respectively, and 24.8%, 13.5%, and 24.1% showed moderate depressive, anxious, and severe symptoms. An overall 10.5% had IBS. Medical students with IBS had a 108% higher prevalence of ED than those without the syndrome (prevalence ratio, 2.08; 95% CI, 1.06-4.06). Other confounding variables were not significantly associated (<i>P</i> > .05).</p><p><strong>Clinical implications: </strong>The results underline the importance of comprehensive sexual and mental health assessment, with an emphasis on the relationship between IBS and ED in medical students.</p><p><strong>Strengths and limitations: </strong>Strengths include the use of validated and reliable instruments and rigorous biostatistical methods, and this is the first Peruvian investigation to explain the association between IBS and ED in medical students. Limitations include the cross-sectional design and nonprobability sampling, and there may be bias in applying the instruments.</p><p><strong>Conclusion: </strong>This study reveals a significant association between IBS and a higher prevalence of ED in these students.</p>","PeriodicalId":21782,"journal":{"name":"Sexual Medicine","volume":"12 2","pages":"qfae021"},"PeriodicalIF":2.6,"publicationDate":"2024-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11076181/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140892127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of the effect of cannabis use before partnered sex on women with and without orgasm difficulty.","authors":"Suzanne Mulvehill, Jordan Tishler","doi":"10.1093/sexmed/qfae023","DOIUrl":"10.1093/sexmed/qfae023","url":null,"abstract":"<p><strong>Background: </strong>Up to 41% of women face challenges achieving orgasm, a statistic unchanged for 50 years.</p><p><strong>Aim: </strong>To evaluate the effect of cannabis use before partnered sex on women with and without difficulty achieving orgasm.</p><p><strong>Methods: </strong>This observational study evaluated responses from female study participants relating to their demographics, sexual activities, mental well-being, cannabis usage, and orgasm-related questions from the Female Sexual Function Index (FSFI).</p><p><strong>Outcomes: </strong>Outcomes included orgasm frequency, difficulty, and satisfaction related to cannabis use or lack of use before partnered sex, largely based on the FSFI orgasm subscale.</p><p><strong>Results: </strong>Of the 1037 survey responses, 410 were valid and complete. Twenty-three surveys (5.6% returned) were excluded due to failure to meet the study's criteria. Of the valid surveys, most women (52%, n = 202) reported difficulty achieving orgasm during sexual activity with a partner. These women were primarily between 25 and 34 years of age (45%, n = 91); 75% identified their race as White (n = 152/202); 52% (n = 105) identified as LGBTQI+ (lesbian, gay, bisexual, transgender, queer/questioning, intersex, or other); and 82% (n = 165) were married or in a relationship. Among participants who experienced challenges in achieving orgasm, 72.8% (n = 147, <i>P</i> < .001) reported that cannabis use before partnered sex increased orgasm frequency, 67% stated that it improved orgasm satisfaction (n = 136, <i>P</i> < .001), and 71% indicated that cannabis use made orgasm easier (n = 143, <i>P</i> < .001). The frequency of cannabis use before partnered sex correlated with increased orgasm frequency for women who experienced difficulties achieving orgasm (n = 202, <i>P</i> < .001). The reasons for cannabis use before partnered sex resulted in a more positive orgasm response (n = 202, <i>P</i> = .22).</p><p><strong>Clinical implications: </strong>Cannabis may be a treatment for women with difficulty achieving orgasm during partnered sex.</p><p><strong>Strengths and limitations: </strong>The researchers examined the challenge of achieving orgasm and considered the covariates reported in the literature, including the FSFI orgasm subscale. The findings may not be generalizable to women who rarely or never use cannabis before sex, women who have never experienced an orgasm, or women who do not have female genitalia. Additionally, the specific type of cannabis used, its chemical composition, the quantity used, and whether or not the partner used cannabis were not assessed in this study.</p><p><strong>Conclusion: </strong>Cannabis-related treatment appears to provide benefit to women who have female orgasm difficulties or dysfunction.</p>","PeriodicalId":21782,"journal":{"name":"Sexual Medicine","volume":"12 2","pages":"qfae023"},"PeriodicalIF":2.6,"publicationDate":"2024-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11071449/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140863944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Monocyte-to-high-density lipoprotein cholesterol ratio and the risk of erectile dysfunction: a study from NHANES 2001-2004.","authors":"Xu Wu, Yuyang Zhang, Hui Jiang, Xiansheng Zhang","doi":"10.1093/sexmed/qfae025","DOIUrl":"10.1093/sexmed/qfae025","url":null,"abstract":"<p><strong>Background: </strong>The monocyte-to-high-density lipoprotein cholesterol ratio (MHR) has become a novel inflammation marker with a possible association with erectile dysfunction (ED); however, there are fewer studies exploring the association between MHR and ED.</p><p><strong>Aim: </strong>This study sought to explore the association between MHR and ED.</p><p><strong>Methods: </strong>This study population was drawn from participants in two 2-year cycles of the National Health and Nutrition Examination Survey (2001-2002 and 2003-2004). MHR was calculated as the ratio of monocyte count (10³ cells/μL) to high-density lipoprotein cholesterol (mg/dL). The relationship between MHR and ED was explored using survey-weighted logistic regression models with MHR as a continuous variable and divided into tertiles (tertile 1 [T1]: <0.01; T2: 0.01-0.014; T3: >0.014). We also used a smooth curve fit (penalized spline method) to characterize the dose-response relationship between MHR and ED. In addition, subgroup analyses based on age, body mass index, smoking, hypertension, diabetes mellitus, and cardiovascular disease were performed to further analyze the data. Sensitivity analyses were also conducted to further assess the stability of the results.</p><p><strong>Outcomes: </strong>The main outcome measure was the difference in ED prevalence between MHR levels.</p><p><strong>Results: </strong>A total of 1361 participants were enrolled, with 513 (T1), 438 (T2), and 410 (T3) participants in the 3 MHR groups. After adjusting for all potential covariates, survey-weighted logistic regression analyses showed a significant association between MHR and ED (odds ratio [OR], 1.96; 95% confidence interval [CI], 1.26-3.05). When MHR was used as a categorical variable, the adjusted OR for ED prevalence increased significantly with increasing MHR after adjusting for all potential covariates (T3 vs T1: OR, 2.14; 95% CI, 1.29-3.55). The dose-response curves showed that the prevalence of ED increased with increasing MHR.</p><p><strong>Clinical implications: </strong>Easy to access and low cost, MHR is a convenient clinical tool that helps clinicians in the prevention and treatment of ED.</p><p><strong>Strengths and limitations: </strong>The present study is the first to examine the association between MHR and ED nationally representative data. However, the study population was derived from a U.S. database, so the findings are limited to the U.S. population.</p><p><strong>Conclusion: </strong>Our study demonstrated that MHR levels were independently associated with ED and that ED patients had higher MHR levels, suggesting that MHR may be a valuable predictor for identifying people at higher risk for ED.</p>","PeriodicalId":21782,"journal":{"name":"Sexual Medicine","volume":"12 2","pages":"qfae025"},"PeriodicalIF":2.6,"publicationDate":"2024-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11074004/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140877219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of local anesthetic on the hypersensitive and nonsensitive areas of the penis is different in primary premature ejaculation: a pilot study","authors":"MD Lei Zheng, MD Le-Tian Wei, MD Song-Chunli, MD Wen-Rong Liu, MD PhD Hui Jiang, MD PhD Tao Jiang","doi":"10.1093/sexmed/qfae020","DOIUrl":"https://doi.org/10.1093/sexmed/qfae020","url":null,"abstract":"Abstract Background Penile hypersensitivity is not the whole penis, but rather only a part of the penis. Though local anesthetic can prolong intravaginal ejaculation latency time by reducing penile hypersensitivity, the effect on the hypersensitive and nonsensitive areas of penis is still unclear. Aim The study aimed to explore whether the effect of local anesthetic on the hypersensitive and nonsensitive areas of the penis is different in premature ejaculation. Methods Penile neurophysiological tests were performed on 290 patients with primary premature ejaculation. The sensory threshold, latency, and amplitude were recorded before and after the topical application of a local anesthetic (lidocaine cream) on the penis. Outcomes Local anesthetics increased the sensory thresholds of hypersensitive and nonsensitive areas of the penis without difference but only prolonged the latency of the hypersensitive areas. Results According to the neurophysiological results, 149 of 290 patients with primary premature ejaculation had normal penile sensitivity and 141 had penile hypersensitivity. While penile hypersensitivity does not necessarily mean that the whole penis is hypersensitive, and may be that only a part of the penis is hypersensitive, and we examined the following hypersensitivities: glans hypersensitivity only (14 cases), shaft hypersensitivity only (77 cases), and whole penis hypersensitivity (50 cases). Local anesthetics (lidocaine cream) increased the sensory thresholds of hypersensitive and nonsensitive areas of the penis without difference (P < .001) but only prolonged the latency of the hypersensitive areas (P < .001), and the latency of the nonsensitive areas was not different (P > .05). Clinical Implications The present discovery implies that it is possible to improve ejaculation by applying local anesthetics externally to the hypersensitive areas of the penis to reduce the afferent local sensory signals, and improve intravaginal ejaculation latency time through accurately decreasing penile sensibility. Strengths & Limitations This is the first large-sample study to explore the difference of local anesthetics’ effects on the hypersensitive and nonsensitive areas of the penis by means of neurophysiological methods in premature ejaculation. Our study exclusively examines alterations in penile evoked potential following electrical stimulation, which may not entirely encompass shifts in penile receptivity during sexual activity. Conclusion The effects of local anesthetics on the same penis varied with penile sensitivity, and can only prolong the latency of hypersensitive area of the penis. The effect of local anesthetic on the hypersensitive and nonsensitive areas of the penis is different in premature ejaculation.","PeriodicalId":21782,"journal":{"name":"Sexual Medicine","volume":"124 2","pages":""},"PeriodicalIF":2.6,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140778027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Italian women who have sex with women: prevalence and co-occurrence of sexual practices","authors":"Sofia Pavanello Decaro, Rodolfo Pessina, Marco Biella, A. Prunas","doi":"10.1093/sexmed/qfae017","DOIUrl":"https://doi.org/10.1093/sexmed/qfae017","url":null,"abstract":"Abstract Background Sexuality research on the sexual practices of women who have sex with women (WSW) has thus far mostly centered on risk factors and addressed a limited number of practices, with a focus on oral sex and insertive vaginal sex. Aim This study arises from the need to fill such a significant gap, which prevents researchers, clinicians, and policy makers from being adequately up-to-date on the sexual habits and tendencies of this population. Methods A multiple-choice questionnaire was completed by 723 WSW with a mean (SD) age of 29.14 (6.94) years. Outcomes The survey included closed questions on sexual practices, including genital and oral sex, but also nongenital sexual contact (petting and intercrural sex), anal sex, and kinky practices. Results The most common sexual practices were self-masturbation (99.03%), oral sex (performed or received, 98.20%), and insertive genital sex (performed or received, 89.07%). Half of our sample had tried kinky practices at least once in a lifetime (51.31%). Respondents tended to experiment sexually more with stable partners rather than with casual ones. Comparisons among practices in the lesbian and bisexual population are presented. Clinical Implications Providers should be aware that sexual orientations have their own specificities, including sexuality and practices, which should increase their knowledge and comfort in working with sexual minorities. Strengths and Limitations The novel topic of the study addresses the gap in sexuality research among WSW. Strengths include the sex-positive approach, the inclusion of an array of sexual practices, and the consideration of the specificities of the group. Limitations in the generalization of the results are the cross-sectional design and the explicit topic, which may have kept some persons from responding. Conclusion We propose the framing of sex as going beyond genital contact, and we invite clinicians and researchers who come into contact with WSW to be aware that sexual orientation can be associated with specificities regarding sexuality and sexual practices.","PeriodicalId":21782,"journal":{"name":"Sexual Medicine","volume":"55 ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140790748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}