Sexual Medicine最新文献

{"title":"The experience of gay Christian men attending collaborative workshops facilitated by a sexual health professional and a priest.","authors":"Remziye Kunelaki, Zoe Bennett, Selim Cellek, Carrie Roder","doi":"10.1093/sexmed/qfaf103","DOIUrl":"10.1093/sexmed/qfaf103","url":null,"abstract":"<p><strong>Background: </strong>Although workshops facilitated by a sexual health professional and a priest to support gay Christian men who struggle with accepting their sexuality and religious identity have been organized, the experience of attending such workshops has not been studied.</p><p><strong>Aim: </strong>To understand the experience of gay Christian men who attended collaborative workshops.</p><p><strong>Methods: </strong>Six collaborative workshops were conducted between a sexual health clinic and a church in central London from January to September 2018. Purposive sampling was used to recruit 11 gay Christian men who participated in the workshops. Data on their experiences were collected through semistructured interviews, images, and the innovative method of haiku poetry, which was used to reflect on their experiences during and after the workshops. All the data were analyzed using thematic analysis.</p><p><strong>Outcome: </strong>Gaining insights into the experiences of gay Christian men who participated in collaborative workshops.</p><p><strong>Results: </strong>The collaborative workshops had a significant impact on gay Christian men in two key areas: self-perception and relationships. The contributing factors to this influence were either environmental or personal. Three themes emerged: motivation, self-development, and the influence of the environment. Some participants embraced the workshops, while others experienced a sense of urgency. The workshops were experienced as fostering their self-growth. In contrast, others were reminded of their destructive behaviors, which left them feeling hopeless. For some participants, the workshop's environment highlighted their minority status as a strength, whereas for others, it highlighted their loneliness.</p><p><strong>Clinical implication: </strong>This study showed the importance of understanding motivation for attending the collaborative workshops.</p><p><strong>Strengths and limitations: </strong>Although the findings cannot be generalized to all religious and sexual minorities, they can inform future collaborations. Although a small sample was recruited, it provided an in-depth understanding of the experiences of these men. Limited funding restricted the workshops' accessibility to hard-to-reach communities. The data were analyzed from a psychological perspective.</p><p><strong>Conclusion: </strong>This study introduces a novel model for integrating religion and sexuality. It adapts Maslow's hierarchy of needs for gay Christian men to include freedom from shame as an essential requirement, subsequently fostering belongingness, connection, and love.</p>","PeriodicalId":21782,"journal":{"name":"Sexual Medicine","volume":"13 6","pages":"qfaf103"},"PeriodicalIF":2.4,"publicationDate":"2025-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12710469/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145782713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prediction of severe erectile dysfunction after penile fracture repair: machine learning analysis results from the reconstruction and trauma working group of the society of urological surgery (RAT-SUS).","authors":"Serdar Geyik, Ismail Onder Yilmaz, Mehmet Zubaroglu, Mutlu Deger, Rahmi Kavak, Hilmi Sari, Yavuz Onur Danacıoglu, Çaglar Sertkaya, Mehmet Yilmaz, Ibrahim Haciobey, Mustafa Tıpırdamaz, Mehmet Dündar, Mesut Berkan Duran, Can Sinirsiz, Omer Bayrak, Onur Zeytun, Alican Albaz, Murat Demir, Yunus Emre Göger, Murat Ucar, Burak Akgül, Ersan Arda, Ilker Akarken, Ahmet Güzel, Mehmet Vehbi Kayra, Ibrahim Güven Kartal, Reha Girgin, Dursun Baba, Gökhan Ceker, Mehmet Özen, Ahmet Gürbüz, Ozgür Yilmaz, Ozan Bozkurt","doi":"10.1093/sexmed/qfaf101","DOIUrl":"10.1093/sexmed/qfaf101","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Erectile dysfunction (ED) is a significant complication following penile fracture repair, and early prediction is critical for clinical management.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Aim: &lt;/strong&gt;To evaluate the effectiveness of machine learning (ML) algorithms in predicting the development of severe ED after penile fracture repair and to identify complex risk factors beyond the scope of traditional statistical methods.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;A retrospective analysis was conducted using data from 547 patients who underwent surgical repair for penile fracture between January 2020 and June 2024 at 23 urology centers affiliated with the Reconstructive Urology and Trauma Study Group of the Urological Surgery Society. Patients were categorized into two groups based on their International Index of Erectile Function-5 scores at six months postoperatively: severe ED (+) (≤7) and ED (-) (&gt;7). Eleven different ML classifiers were evaluated to determine the most predictive models. Four distinct resampling techniques were employed to address class imbalance in the dataset. Feature importance analysis was also performed to identify the most influential variables contributing to ED risk.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Outcomes: &lt;/strong&gt;This study was conducted to enable the early identification of patients at high risk of developing severe ED following penile fracture surgery.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;Logistic Regression, Gaussian Naive Bayes, and Linear Support Vector Machine emerged as the best-performing algorithms on the original dataset, with Area Under the Curve (AUC) scores of 0.81, 0.78, and 0.76, respectively. On the Synthetic Minority Over-sampling Technique (SMOTE)-resampled dataset, Quadratic Discriminant Analysis (QDA) achieved an AUC of 0.85, while the Artificial Neural Network (ANN) reached an AUC of 0.84. On the SMOTE-resampled dataset, QDA achieved a ROC-AUC of 0.85 (95% CI: 0.75-0.93), whereas on the SMOTE-Tomek Link-resampled dataset, the ANN attained a ROC-AUC of 0.84 (95% CI: 0.71-0.94). The most critical predictors of severe ED were age, comorbidities, tunical tear length, and time to surgery. Urethral injuries were not significant contributors, as all were minor and managed conservatively without urethroplasty.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Clinical implications: &lt;/strong&gt;Integration of ML-based prediction models into clinical workflows could support early risk stratification and individualized patient care, ultimately improving postoperative functional outcomes.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Strengths and limitations: &lt;/strong&gt;This study benefits from a large, multicenter dataset and a comparative analysis of multiple ML algorithms. However, its retrospective nature and inter-center variability in data reporting may limit generalizability.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;ML algorithms are effective and reliable tools for predicting severe ED after penile fracture repair and may enhance personalized postoperative management. Eliminating class imbalance i","PeriodicalId":21782,"journal":{"name":"Sexual Medicine","volume":"13 6","pages":"qfaf101"},"PeriodicalIF":2.4,"publicationDate":"2025-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12710470/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145782691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gender transition and intellectual developmental disorders: a case report.","authors":"Lorenzo Soldati, Fabienne Gerber, Sotiria Maria Iliopoulou, Markus Kosel","doi":"10.1093/sexmed/qfaf098","DOIUrl":"10.1093/sexmed/qfaf098","url":null,"abstract":"<p><strong>Introduction: </strong>Various studies have shown a high association between gender incongruence (GI) and mental disorders, and a higher presence of GI in certain populations such as autism spectrum disorder. The scientific literature on GI in people with intellectual developmental disorder (IDD) is very sparse, no data on the effects of gender-affirming hormone therapy and gender-affirming surgery are available.</p><p><strong>Aims: </strong>We report the first case of an individual with GI and IDD and comorbid psychiatric disorders who underwent gender-affirming treatments, with a largely positive outcome.</p><p><strong>Methods: </strong>We describe the diagnostic assessment and the course of treatment of a transgender man, assigned female at birth, with a mild IDD (IQ 53) and bipolar disorder, who benefited from gender-affirming hormone therapy, followed by gender-affirming surgery such as torsoplasty with bilateral mastectomy, hysterectomy with oophorectomy, colpectomy, and proximal urethroplasty and finally phalloplasty. He also benefited from appropriate psychological support and from treatments to stabilize psychiatric disorders.</p><p><strong>Results: </strong>Two years after the phalloplasty, he reports complete disappearance of GI. Psychiatric symptoms have reduced, in terms of anxiety and mood swings, to the point where psychiatric hospitalization were no longer necessary since torsoplasty with bilateral mastectomy. His social functioning has also improved.</p><p><strong>Conclusion: </strong>This case report provides a clear focus on the importance of multidisciplinary work between IDD and GI specialists to evaluate and manage GI in individuals with IDD. It addresses the complexity of gender identity exploration and expression for individuals with IDD and brings attention to their vulnerability. This case report offers limited exploration of practical solutions or interventions and does not provide detailed treatments strategies. Given the complexity of this case report, which involves both IDD and bipolar disorder, it is challenging to draw generalizations or definitive conclusions.</p>","PeriodicalId":21782,"journal":{"name":"Sexual Medicine","volume":"13 6","pages":"qfaf098"},"PeriodicalIF":2.4,"publicationDate":"2025-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12704416/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145768966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pelvic organ prolapse burden on sexual health and body image: a cross-sectional study.","authors":"Roxana Geoffrion, Melissa Tigert, Jens-Erik Walter, May Sanaee, Erin A Brennand, Ola Malabarey, Maryse Larouche, Momoe Hyakutake, Fariba Mohtashami, Katherine Rabicki, Lina Roa, Terry Lee, Joel Singer, Nicole Koenig, Lori A Brotto","doi":"10.1093/sexmed/qfaf100","DOIUrl":"10.1093/sexmed/qfaf100","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Pelvic organ prolapse (POP) is common and can affect sexual health and body image. Sexual concerns of non-sexually active (NSA) females with POP have been poorly described.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Aim: &lt;/strong&gt;To describe the burden of POP and explore associations between sexual function and body image in all patients seeking surgery.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;Secondary analysis of a baseline patient cohort, randomized controlled trial (RCT) of 2 POP reconstructive surgeries at 5 urogynecology tertiary centers. We present baseline sexual activity, function, and sex-related affect and body image. Patients scheduled for POP surgery completed validated condition-specific questionnaires of sexual function, body image, demographics, POP burden, and medical comorbidities. We used descriptive statistics and appropriate tests of significance.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Outcomes: &lt;/strong&gt;Differences between sexually active (SA) and NSA patients in POP-specific sexual function and body image; associations between body image and impaired sexual function.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;Of 181 patients, 86 (47.5%) were SA, with a mean (SD) of age 62 (11.1). SA patients were younger, with fewer comorbidities. 30/86 (35%) had clinically significant sexual function impairment. Reasons for being NSA included pelvic symptoms (69.1%), lack of interest (53.8%), and lack of partner (40.5%). Frustration, sexual inferiority, and anger were similar between NSA and SA patients. NSA patients have 5 times the odds of avoiding sexual activity because of fear of pelvic symptoms; twice the odds of being more dissatisfied and twice the odds of feeling more inadequate in their sex life than SA patients. (&lt;i&gt;P&lt;/i&gt; &lt; .05, unadjusted and adjusted analyses). A total of 171 patients (80% partnered) had similar body image scores between SA and NSA patients. Partnered NSA patients were more likely than SA to avoid sexual intimacy because of POP, aOR 2.35 (95% CI, 1.03-5.33). Patients who had clinically significant POP-related impairment of sexual function had significantly worse body image (&lt;i&gt;P&lt;/i&gt; &lt; .001).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Clinical implications: &lt;/strong&gt;Patients with clinically bothersome POP have significant sexual concerns. Body image was similarly affected regardless of sexual activity. Perceived partner avoidance of intimacy was a common barrier. This is an opportunity for tailored sexual health individual and couples counseling.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Strengths and limitations: &lt;/strong&gt;Our findings apply to many surgical POP patients regardless of partner or sexual activity status. Limitations include missing data, no validated measure of sexual distress, and no evaluation of partner sexual function.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;The burden of POP-related sexual dysfunction and corresponding poor body image is substantial in both SA and NSA patients awaiting POP surgery. In the preoperative assessment of POP, sexual health and body image questions should be routine","PeriodicalId":21782,"journal":{"name":"Sexual Medicine","volume":"13 6","pages":"qfaf100"},"PeriodicalIF":2.0,"publicationDate":"2025-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12780765/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145952980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Different faces of anxiety in sexual dysfunction: key features, effective interventions, and critical implications for health care professionals-ESSM position statements.","authors":"Paraskevi-Sophia Kirana, Jacques J D M van Lankveld, Marieke Dewitte, David L Rowland","doi":"10.1093/sexmed/qfaf097","DOIUrl":"10.1093/sexmed/qfaf097","url":null,"abstract":"<p><strong>Introduction: </strong>In the field of sexual health research, anxiety stands out as a pivotal element recognized by both researchers and clinicians for its potential to disrupt multiple phases of the sexual response cycle. While research on anxiety and sexual dysfunctions has typically focused on studying various manifestations of anxiety separately, clinical practice often reveals a different reality, with patients frequently experiencing multiple types of anxiety simultaneously.</p><p><strong>Aims: </strong>The objectives of this paper are to provide a comprehensive understanding of the diverse manifestations of sex-related anxiety and their clinical implications, and to identify and highlight existing scientific gaps that require further investigation.</p><p><strong>Methods: </strong>This statement paper is an expert opinion-based proposal developed under the auspices of the European Society for Sexual Medicine (ESSM). A group of experts designed a conceptual framework on anxiety related to sexual dysfunctions and reviewed the literature from 2005 to 2023 across various databases focusing on five anxiety domains, sexual performance anxiety, sexual phobia, sexual distress, attachment anxiety, and somatic symptom disorder, leading to consensus on position statements. The process included revisions approved by the ESSM Executive Committee and affiliate societies.</p><p><strong>Results: </strong>Eighteen statements on anxiety in individuals with sexual dysfunctions were developed, including three general statements on anxiety, three on sexual performance anxiety, three on sexual phobias, three on sexual distress, three on attachment anxiety, and three on somatic symptom disorder. Each type of anxiety was further described in terms of its prevalence, assessment, covariates and consequences, intervention strategies, and future directions for research.</p><p><strong>Conclusion: </strong>Clinicians addressing sexual dysfunctions should screen for signs of various types of anxiety and assess their interference with sexual situations, overall sexual life, and broader life functioning. The literature suggests specific treatment approaches for different anxiety manifestations, emphasizing the need for tailored interventions. Treatments should be carefully selected based on the type of anxiety identified.</p>","PeriodicalId":21782,"journal":{"name":"Sexual Medicine","volume":"13 6","pages":"qfaf097"},"PeriodicalIF":2.4,"publicationDate":"2025-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12684971/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145715714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Awareness, use, and acceptability of HIV pre-exposure prophylaxis and post-exposure prophylaxis among men who have sex with men: evidence from China.","authors":"Zhujun Lian, Xingliang Zhang, Junfang Xu","doi":"10.1093/sexmed/qfaf093","DOIUrl":"10.1093/sexmed/qfaf093","url":null,"abstract":"<p><strong>Background: </strong>Men who have sex with men (MSM) represent a high-incidence population with HIV, while HIV pre-exposure prophylaxis (PrEP) and post-exposure prophylaxis (PEP) are among the most effective interventions to prevent HIV transmission and save lives.</p><p><strong>Aim: </strong>This study aims to analyze the awareness, use, and acceptability of HIV PrEP and PEP among MSM to inform optimized implementation strategies for this population.</p><p><strong>Methods: </strong>A non-government organization based questionnaire survey was used to collect data from July 2022 to December 2023. A total of 1065 MSM were incorporated into our analysis with the following information: socio-demographics, awareness, use, and acceptability of HIV PrEP and PEP. Binary logistic regression analysis was employed to determine the factors on seeking, use, and acceptability of PrEP and PEP.</p><p><strong>Outcomes: </strong>Despite high awareness of PrEP/PEP, actual adoption remained limited among MSM.</p><p><strong>Results: </strong>The average age of the participants was 28.48 ± 7.33. About 89.7% of the participants were aware of PrEP and 94.4% were aware of PEP. About 7.9% of the participants have used PrEP and 11.6% have used PEP. About 87.9% of the participants had willingness to use PrEP and 90.2% had willingness to use PEP. The main ways for the participants to get PrEP and PEP were through Internet hospitals, followed by local hospitals, and recommendations from acquaintances. The most concerned factors were preventive effect followed by side effects of PrEP and PEP. Doubts about the preventive effect of PrEP and PEP significantly affect their seeking, use, and acceptability (<i>P</i> < .05).</p><p><strong>Clinical translation: </strong>This study provides insights for enhancing the implementation of HIV PrEP and PEP among MSM.</p><p><strong>Strengths and limitations: </strong>This study is the first to depict the situation of awareness, use, and acceptability of HIV PrEP and PEP among MSM in China. Limitations involve social desirability bias and reliance on self-reported diagnosis.</p><p><strong>Conclusion: </strong>Accelerating PrEP/PEP scale-up requires enhanced risk perception, expanded service access, and comprehensive sensitization programs.</p>","PeriodicalId":21782,"journal":{"name":"Sexual Medicine","volume":"13 6","pages":"qfaf093"},"PeriodicalIF":2.4,"publicationDate":"2025-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12676726/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145701589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Disproportionately low authorship by women urologists in sexual medicine journals.","authors":"Sonam Saxena, Akhil Peta, Michael Raver, Simon Gelman, Matthew Yang, Maie Abdel-Wahab, Nolan Holbrook, Sophia Zhang, Jamie Chen, Sarah Brink, David Shin","doi":"10.1093/sexmed/qfaf095","DOIUrl":"10.1093/sexmed/qfaf095","url":null,"abstract":"<p><strong>Background: </strong>The recent efforts to increase the proportion of women in urology have demonstrated success; it is equally important to evaluate success of these efforts in urologic sub-specialized fields as well.</p><p><strong>Aim: </strong>This study aims to evaluate the impact of these efforts and the representation of women urologists in the sexual medicine literature.</p><p><strong>Methods: </strong>Original research manuscripts from three prominent sexual medicine journals from 2013 to 2023 were collected. Manuscripts submitted under Paraphilia subsections, as well as systematic reviews, meta-analyses, communications, commentaries, replies, and those involving psychometrics were excluded. Proportion of women authors in these journals' literature was determined by searching names of first and last authors on the Internet.</p><p><strong>Outcomes: </strong>This study evaluates whether authorship by women in sexual medicine literature has increased following recent efforts to enhance their representation in urology and related fields.</p><p><strong>Results: </strong>1065 of 2701 (39%) collected manuscripts meeting criteria were from first (FA) or last authors (LA). Women were significantly less likely to be FA or LAs across these manuscripts (<i>P</i>< 0.001).Further, variables such as author degree, field, profession, and institution type all demonstrated significant gender disparities in FA and LA as well. Representation of women FAs and LAs was lowest in urology (15%, 5%) compared to obstetrics and gynecology (64%, 55%) and psychology (68%, 63%).</p><p><strong>Clinical implications: </strong>These disparities in sexual medicine publications have important consequences for women urologists; these opportunities often impact future career advancement in academia.</p><p><strong>Strengths and limitations: </strong>Gender identification relied on traditional markers (such as names and pronouns), which may not fully capture the diversity of gender identities, we sought to mediate that by using a binary identification method. The analysis was also limited to first and last authorship, which may not capture contributions from middle authors.</p><p><strong>Conclusion: </strong>Although the push to increase the proportion of women urologists has shown success, there are still significant disparities seen in publication of sexual medicine literature. Potential avenues for improvement include mentorship and targeted institutional support.</p>","PeriodicalId":21782,"journal":{"name":"Sexual Medicine","volume":"13 6","pages":"qfaf095"},"PeriodicalIF":2.4,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12667258/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145661621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optical assessment of genital changes associated with female sexual arousal: a mini-review.","authors":"Hyeryun Jeong, Myeongsu Seong, Kwangsung Park, Jae Gwan Kim","doi":"10.1093/sexmed/qfaf065","DOIUrl":"https://doi.org/10.1093/sexmed/qfaf065","url":null,"abstract":"<p><strong>Background: </strong>Optical techniques, including laser Doppler flowmetry (LDF), photoplethysmography (PPG), and near-infrared spectroscopy (NIRS), are emerging as one of the most popular tools for female sexual arousal response (FSAR) assessment. However, to our knowledge, no narrative reviews have focused on the application of these optical techniques in FSAR assessment.</p><p><strong>Aim: </strong>To fill out the existing gap, we review the literature regarding using optical techniques in FSAR assessment in preclinical and clinical studies.</p><p><strong>Methods: </strong>A literature search was performed on the manuscript with terms including \"female sexual dysfunction, FSAR, LDF, PPG, NIRS\" between 1974 and 2024 using PubMed, Google Scholar, and MEDLINE. Among the articles identified, 18 articles were reviewed after excluding articles with non-relevant topics, duplicate articles, and articles not written in English.</p><p><strong>Outcomes: </strong>This article reviews 11 studies that used LDF/imaging, four studies that used PPG, and three studies that used NIRS, including the employed experimental protocols in each study.</p><p><strong>Results: </strong>Various optical techniques were used in FSAR assessment during electrical stimulation, visual and tactile stimulation, and drug administration. Additional studies, including using non-human primate models, testing the effects of different anesthetics on FSAR in preclinical studies, and performing more clinical studies to develop a standard for human FSAR monitoring using optical techniques that can lead to the use of optical techniques in clinical practices, could be considered. Meanwhile, non-contact systems and other optical techniques like optical coherence tomography, photoacoustic endoscopy, and Raman spectroscopy can be developed for future FSAR studies.</p><p><strong>Clinical translation: </strong>This article can provide a good overview of the preclinical and clinical investigations of FSAR using LDF, PPG, and NIRS. Understanding the differences between the techniques will allow clinicians to choose an appropriate technique for their FSAR studies.</p><p><strong>Strengths and limitations: </strong>This review is the first to overview various optical techniques used to evaluate FSAR. A limitation of the review is that there is no clinical study that uses NIRS for FSAR monitoring.</p><p><strong>Conclusions: </strong>LDF/imaging, PPG, and NIRS have been used in various FSAR investigations. Such optical techniques have the potential to be used in future FSAR studies to quantitatively analyze the physiological changes during FSAR.</p>","PeriodicalId":21782,"journal":{"name":"Sexual Medicine","volume":"13 5","pages":"qfaf065"},"PeriodicalIF":2.0,"publicationDate":"2025-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12648246/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145638704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Food effect on pharmacokinetic profiles of sildenafil 100 mg oral films in healthy male volunteers: results from two randomized, single dose, crossover studies.","authors":"Quan Minh Pham, Dimitri Yannas, Andrea Sansone, Javier Romero-Otero, Pedro Vendeira, Valeria Frangione, Emmanuele A Jannini","doi":"10.1093/sexmed/qfaf096","DOIUrl":"10.1093/sexmed/qfaf096","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Decades after it was first put on the market, sildenafil is still a very successful treatment for erectile dysfunction. New formulations, such orodispersible films (ODFs), offer more convenience allowing more discreet use and enabling people who might have trouble swallowing tablets to take the drug.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Aim: &lt;/strong&gt;To evaluate the impact of food and water on sildenafil ODF as compared to sildenafil film-coated tablet (FCT) and to assess the safety and palatability of the orodispersible formulation.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;Two randomized, single-dose, three-period, crossover studies were conducted on healthy male volunteers. The first study, involving 45 subjects, was designed to compare ODF versus FCT under fasting conditions and to study the effect of high-fat, high-calorie meal on ODF pharmacokinetic (PK) profiles. The second study, involving 35 subjects, compared ODF versus FCT under fed conditions and the effect of water on ODF PK profiles. Blood samples were collected within 24 h post-dosing to measure plasma sildenafil and its metabolite, &lt;i&gt;N&lt;/i&gt;-desmethyl-sildenafil.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Outcomes: &lt;/strong&gt;Primary outcomes were maximum observed plasma concentration (&lt;i&gt;C&lt;/i&gt; &lt;sub&gt;max&lt;/sub&gt;), the area under the concentration-time curve (AUC), and the time of maximum observed plasma concentration (&lt;i&gt;T&lt;/i&gt; &lt;sub&gt;max&lt;/sub&gt;). Secondary outcomes included palatability and safety.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;Food delayed sildenafil 100 mg ODF &lt;i&gt;T&lt;/i&gt; &lt;sub&gt;max&lt;/sub&gt; by 1.45 h and decreased &lt;i&gt;C&lt;/i&gt; &lt;sub&gt;max&lt;/sub&gt; by 45% but did not affect the extent of systemic exposure to sildenafil (AUC). Bioequivalence was demonstrated for sildenafil ODF administered with and without water under fed conditions. &lt;i&gt;C&lt;/i&gt; &lt;sub&gt;max&lt;/sub&gt; of plasma sildenafil was ~13% and 17% lower for ODF (without and with water, respectively), and &lt;i&gt;T&lt;/i&gt; &lt;sub&gt;max&lt;/sub&gt; was delayed by 1-1.5 h, compared to FCT under fed conditions, but both AUC&lt;sub&gt;0-t&lt;/sub&gt; and AUC&lt;sub&gt;0-∞&lt;/sub&gt; met the bioequivalence limits. Palatability was acceptable with mild aftertastes. The ODF formulation was well-tolerated with no severe adverse events.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Clinical implications: &lt;/strong&gt;Sildenafil ODF is a bioequivalent alternative to traditional tablets. The food impact on sildenafil ODF taken with and without water is consistent with that associated with FCT, influencing &lt;i&gt;C&lt;/i&gt; &lt;sub&gt;max&lt;/sub&gt; and &lt;i&gt;T&lt;/i&gt; &lt;sub&gt;max&lt;/sub&gt; but not AUC.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Strengths and limitations: &lt;/strong&gt;The study population consisted exclusively of healthy subjects, and the study was limited to single-dose administration. Lastly, although bioequivalence of PKs implies therapeutic equivalence, future studies incorporating clinical endpoints would offer more conclusive evidence of interchangeability.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;Sildenafil ODF has comparable PKs and added convenience for patients. Its versatility, ease of use, and discreetness make it idea","PeriodicalId":21782,"journal":{"name":"Sexual Medicine","volume":"13 5","pages":"qfaf096"},"PeriodicalIF":2.0,"publicationDate":"2025-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12640539/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145597196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing the relationship between sexual health literacy and sexual self-care in women: a cross-sectional study in Iran.","authors":"Fatemeh Darban, Nastaran Heydarikhayat, Sahar Olyaee, Nazanin Raeisi","doi":"10.1093/sexmed/qfaf071","DOIUrl":"10.1093/sexmed/qfaf071","url":null,"abstract":"<p><strong>Background: </strong>Sexual self-care behaviors in women play a crucial role in promoting their sexual health, ultimately enhancing family and societal well-being. Adequate knowledge and the ability to apply such information are key factors influencing sexual self-care.</p><p><strong>Aim: </strong>This study was conducted to examine the relationship between sexual health literacy and sexual self-care among women.</p><p><strong>Methods: </strong>This cross-sectional study was conducted among 435 women of reproductive age attending healthcare centers affiliated with Iranshahr University of Medical Sciences, Iran, during 2024-2025. Data were collected using validated questionnaires on sexual self-care and the Iranian Adult Sexual Health Literacy scale. Statistical analysis was performed using SPSS 22, employing logistic regression, analysis of variance (ANOVA), and multiple linear regression models.</p><p><strong>Outcomes: </strong>Determined the relationship between sexual health literacy and sexual self-care in young women.</p><p><strong>Results: </strong>The results revealed a statistically significant direct association between sexual self-care and sexual health literacy (<i>P</i> = .000). Women demonstrating higher sexual health literacy scores reported higher sexual self-care scores. Sexual self-care was associated with total sexual health literacy scores, as well as with the dimensions of information access skills and information application skills.</p><p><strong>Clinical implications: </strong>The results provide a rationale for policymakers to implement targeted sexual health literacy programs, which can subsequently enhance self-care practices.</p><p><strong>Strengths and limitations: </strong>The strengths of this study include the use of robust statistical methods and a large, representative sample size. However, limitations should be noted, such as the dependence on self-reported data, which may introduce bias, and the restricted generalizability of findings due to the single-region, cross-sectional study design.</p><p><strong>Conclusion: </strong>This study demonstrated that improved sexual health literacy enhances sexual self-care scores in women. These results highlight the crucial need to enhance women's sexual health literacy.</p>","PeriodicalId":21782,"journal":{"name":"Sexual Medicine","volume":"13 5","pages":"qfaf071"},"PeriodicalIF":2.0,"publicationDate":"2025-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12629225/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145565039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}