{"title":"基于二维：四维手指比值对边缘型人格障碍患者性取向的评估。","authors":"Justyna Holka-Pokorska, Adam Kucharski","doi":"10.1093/sexmed/qfaf006","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>The hormonal composition of amniotic fluid during prenatal development, particularly the androgen-to-estrogen ratio, may influence neuronal differentiation related to sexual response patterns and the capacity to control impulsive sexual behaviors in later life.</p><p><strong>Aim: </strong>This study aims to assess sexual behaviors and characterize sexual responses in women with borderline personality disorder (BPD) compared to a control group.</p><p><strong>Methods: </strong>The study included 33 women diagnosed with BPD and 56 women in a control group. BPD diagnoses were based on clinical psychiatric evaluation and the Structured Clinical Interview for DSM-IV. Elements of sexual response were measured using the Arizona Sexual Experience Scale (ASEX). The digit ratio (2D:4D) served as a biomarker for testosterone and estrogen exposure during early prenatal development.</p><p><strong>Main outcomes: </strong>ASEX results were analyzed in the categories of \"desire,\" \"arousal,\" and \"vaginal lubrication\" subscales, along with the 2D:4D digit ratio for both hands.</p><p><strong>Results: </strong>Lower values for the right-hand digit ratio were observed in the BPD group compared to the control group (0.989, SD = 0.034 vs. 1.016, SD = 0.039; <i>P</i> = 0.0014), potentially indicating higher prenatal testosterone levels. Significant correlations were found in the BPD group between the right-hand digit ratio and scores on the ASEX subscales, specifically \"sexual arousal\" (<i>r</i> = 0.406, <i>P</i> = 0.019) and \"vaginal lubrication\" (<i>r</i> = 0.362, <i>P</i> = 0.038).</p><p><strong>Clinical implications: </strong>These results may support biological hypotheses regarding the origins of sexual dysfunction in women with BPD.</p><p><strong>Strengths and limitations: </strong>This study is a pioneering attempt to explore the indirect impact of early amniotic hormone composition on the neurobiological conditioning of sexual response and behavior in women with BPD. Limitations include the preliminary nature of the findings, a small sample size, and results that may not be generalizable across all genders.</p><p><strong>Conclusions: </strong>Physiological aspects of sexual response, such as arousal and vaginal lubrication, in women with BPD appear to be significantly correlated with prenatal testosterone levels, as indicated by the 2D:4D digit ratio.</p>","PeriodicalId":21782,"journal":{"name":"Sexual Medicine","volume":"13 1","pages":"qfaf006"},"PeriodicalIF":2.6000,"publicationDate":"2025-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11828702/pdf/","citationCount":"0","resultStr":"{\"title\":\"The assessment of the sexuality of patients with a borderline personality disorders based on their 2D:4D digit ratio.\",\"authors\":\"Justyna Holka-Pokorska, Adam Kucharski\",\"doi\":\"10.1093/sexmed/qfaf006\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>The hormonal composition of amniotic fluid during prenatal development, particularly the androgen-to-estrogen ratio, may influence neuronal differentiation related to sexual response patterns and the capacity to control impulsive sexual behaviors in later life.</p><p><strong>Aim: </strong>This study aims to assess sexual behaviors and characterize sexual responses in women with borderline personality disorder (BPD) compared to a control group.</p><p><strong>Methods: </strong>The study included 33 women diagnosed with BPD and 56 women in a control group. BPD diagnoses were based on clinical psychiatric evaluation and the Structured Clinical Interview for DSM-IV. Elements of sexual response were measured using the Arizona Sexual Experience Scale (ASEX). The digit ratio (2D:4D) served as a biomarker for testosterone and estrogen exposure during early prenatal development.</p><p><strong>Main outcomes: </strong>ASEX results were analyzed in the categories of \\\"desire,\\\" \\\"arousal,\\\" and \\\"vaginal lubrication\\\" subscales, along with the 2D:4D digit ratio for both hands.</p><p><strong>Results: </strong>Lower values for the right-hand digit ratio were observed in the BPD group compared to the control group (0.989, SD = 0.034 vs. 1.016, SD = 0.039; <i>P</i> = 0.0014), potentially indicating higher prenatal testosterone levels. Significant correlations were found in the BPD group between the right-hand digit ratio and scores on the ASEX subscales, specifically \\\"sexual arousal\\\" (<i>r</i> = 0.406, <i>P</i> = 0.019) and \\\"vaginal lubrication\\\" (<i>r</i> = 0.362, <i>P</i> = 0.038).</p><p><strong>Clinical implications: </strong>These results may support biological hypotheses regarding the origins of sexual dysfunction in women with BPD.</p><p><strong>Strengths and limitations: </strong>This study is a pioneering attempt to explore the indirect impact of early amniotic hormone composition on the neurobiological conditioning of sexual response and behavior in women with BPD. Limitations include the preliminary nature of the findings, a small sample size, and results that may not be generalizable across all genders.</p><p><strong>Conclusions: </strong>Physiological aspects of sexual response, such as arousal and vaginal lubrication, in women with BPD appear to be significantly correlated with prenatal testosterone levels, as indicated by the 2D:4D digit ratio.</p>\",\"PeriodicalId\":21782,\"journal\":{\"name\":\"Sexual Medicine\",\"volume\":\"13 1\",\"pages\":\"qfaf006\"},\"PeriodicalIF\":2.6000,\"publicationDate\":\"2025-02-15\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11828702/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Sexual Medicine\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1093/sexmed/qfaf006\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/2/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q1\",\"JCRName\":\"MEDICINE, GENERAL & INTERNAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Sexual Medicine","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1093/sexmed/qfaf006","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/2/1 0:00:00","PubModel":"eCollection","JCR":"Q1","JCRName":"MEDICINE, GENERAL & INTERNAL","Score":null,"Total":0}
引用次数: 0
摘要
背景：胎儿发育过程中羊水的激素组成，特别是雄激素与雌激素的比例，可能会影响与性反应模式相关的神经元分化，以及在以后的生活中控制冲动性行为的能力。目的：本研究旨在评估边缘型人格障碍（BPD）女性的性行为和性反应特征，并与对照组进行比较。方法：研究包括33名诊断为BPD的女性和56名对照组女性。BPD的诊断基于临床精神病学评估和DSM-IV的结构化临床访谈。性反应要素采用亚利桑那性经验量表（ASEX）进行测量。手指比例（2D:4D）是产前早期发育过程中睾酮和雌激素暴露的生物标志物。主要结果：ASEX结果在“欲望”、“性唤起”和“阴道润滑”亚量表中进行了分析，同时还分析了双手的2D:4D手指比例。结果：BPD组右手指比值低于对照组(0.989,SD = 0.034 vs. 1.016, SD = 0.039；P = 0.0014)，可能表明产前睾酮水平较高。在BPD组中，右手手指比例与ASEX子量表得分之间存在显著相关性，特别是“性唤起”（r = 0.406, P = 0.019）和“阴道润滑”（r = 0.362, P = 0.038）。临床意义：这些结果可能支持关于BPD女性性功能障碍起源的生物学假设。优势和局限性：本研究是探索早期羊水激素成分对BPD女性性反应和性行为的神经生物学调节的间接影响的开创性尝试。局限性包括研究结果的初步性质，样本量小，结果可能不能推广到所有性别。结论：2D:4D手指比值显示，BPD女性性反应的生理方面，如性唤起和阴道润滑，似乎与产前睾酮水平显著相关。
The assessment of the sexuality of patients with a borderline personality disorders based on their 2D:4D digit ratio.
Background: The hormonal composition of amniotic fluid during prenatal development, particularly the androgen-to-estrogen ratio, may influence neuronal differentiation related to sexual response patterns and the capacity to control impulsive sexual behaviors in later life.
Aim: This study aims to assess sexual behaviors and characterize sexual responses in women with borderline personality disorder (BPD) compared to a control group.
Methods: The study included 33 women diagnosed with BPD and 56 women in a control group. BPD diagnoses were based on clinical psychiatric evaluation and the Structured Clinical Interview for DSM-IV. Elements of sexual response were measured using the Arizona Sexual Experience Scale (ASEX). The digit ratio (2D:4D) served as a biomarker for testosterone and estrogen exposure during early prenatal development.
Main outcomes: ASEX results were analyzed in the categories of "desire," "arousal," and "vaginal lubrication" subscales, along with the 2D:4D digit ratio for both hands.
Results: Lower values for the right-hand digit ratio were observed in the BPD group compared to the control group (0.989, SD = 0.034 vs. 1.016, SD = 0.039; P = 0.0014), potentially indicating higher prenatal testosterone levels. Significant correlations were found in the BPD group between the right-hand digit ratio and scores on the ASEX subscales, specifically "sexual arousal" (r = 0.406, P = 0.019) and "vaginal lubrication" (r = 0.362, P = 0.038).
Clinical implications: These results may support biological hypotheses regarding the origins of sexual dysfunction in women with BPD.
Strengths and limitations: This study is a pioneering attempt to explore the indirect impact of early amniotic hormone composition on the neurobiological conditioning of sexual response and behavior in women with BPD. Limitations include the preliminary nature of the findings, a small sample size, and results that may not be generalizable across all genders.
Conclusions: Physiological aspects of sexual response, such as arousal and vaginal lubrication, in women with BPD appear to be significantly correlated with prenatal testosterone levels, as indicated by the 2D:4D digit ratio.
期刊介绍：
Sexual Medicine is an official publication of the International Society for Sexual Medicine, and serves the field as the peer-reviewed, open access journal for rapid dissemination of multidisciplinary clinical and basic research in all areas of global sexual medicine, and particularly acts as a venue for topics of regional or sub-specialty interest. The journal is focused on issues in clinical medicine and epidemiology but also publishes basic science papers with particular relevance to specific populations. Sexual Medicine offers clinicians and researchers a rapid route to publication and the opportunity to publish in a broadly distributed and highly visible global forum. The journal publishes high quality articles from all over the world and actively seeks submissions from countries with expanding sexual medicine communities. Sexual Medicine relies on the same expert panel of editors and reviewers as The Journal of Sexual Medicine and Sexual Medicine Reviews.
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