上海口腔医学最新文献

{"title":"[Abnormal characteristics of tongue consonants and their correlation with articulatory movement parameters in patients with tongue cancer after surgery].","authors":"Feng Yuan, Liu Lu-Lu, Yue-Yue Liang, Ming-Ming Cao, Zhi-Hui Xu, Chuan-Ru Qian, Dong Wang, Kai Zhang","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Purpose: </strong>To study the abnormal characteristics of tongue consonants and their correlation with articulatory movement parameters in patients with tongue cancer after operation.</p><p><strong>Methods: </strong>A total of 119 patients with tongue cancer who received surgical treatment at First Affiliated Hospital of Bengbu Medical University from March 2019 to May 2023 were selected. The patients were divided into tongue margin group(n=38), tongue body group (n=40) and tongue base group(n=41). Twenty-five monosyllabic words in Huang Zhaoming-Han Zhijuan Vocabulary List for evaluating tongue consonants were used as speech assessment tools to evaluate the errors of each tongue consonant. The articulation speech measurement and training instrument were used to extract the second formants (F2) of the /i/ and /u/ vowels of the patients by linear predictive spectrum, and the articulation movement parameters such as tongue distance and F2i/F2u were calculated according to the formula. SPSS 26.0 software package was used for data analysis.</p><p><strong>Results: </strong>The rate of tongue consonant error in each group was as follows: in tongue margin group, preapical sound (49.5%)＞ apical middle sound (27.8%)＞ apical postapical sound (17.5%)＞lingual facial sound (9.4%)＞ lingual base sound (6.1%). In tongue body group, preapical sound (55.0%)＞ apical middle sound (47.1%) ＞ apical postapical sound (25.4%)＞lingual facial sound (12.1%)＞lingual base sound (3.3%). In tongue base group, preapical sound (60.0%)＞postapical sound (52.0%) ＞apical medium sound (51.9%)＞lingual base sound (44.3%)＞lingual facial sound (34.8%). The error frequency of tongue apex medium sound in tongue body group and tongue base group was significantly higher than that in tongue margin group, and the error frequency of tongue apex posterior sound, tongue surface sound and tongue base sound in tongue base group was significantly higher than that in tongue body group and tongue margin group(P＜0.05). Tongue distance and F2i/F2u in tongue base group were significantly lower than those in tongue margin group and tongue body group, and tongue distance and F2i/F2u in tongue body group were significantly lower than those in tongue margin group(P＜0.05). Tongue distance, F2i/F2u were significantly negatively correlated with the error frequency of apical midpoint, apical postpoint and base sound in all groups(r＜0, P＜0.05).</p><p><strong>Conclusions: </strong>Most patients with tongue cancer after operation have abnormal tongue tip, and the most serious problem is the pretip. In clinical practice, objective parameters such as tongue distance and F2i/F2u can be used to quantitatively and indirectly evaluate the articulation status and dynamic rehabilitation effect of tongue cancer patients after surgery.</p>","PeriodicalId":21709,"journal":{"name":"上海口腔医学","volume":"34 1","pages":"74-78"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143980640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Application of 3D CT reconstruction in the prognostic evaluation of orthodontic treatment for skeletal Class Ⅱ malocclusion].","authors":"Yuan Liu, Li-Li Ding","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Purpose: </strong>To explore the clinical value of 3D computed tomography (CT) reconstruction in the prognostic evaluation of orthodontic treatment for patients with skeletal Class Ⅱ malocclusion.</p><p><strong>Methods: </strong>A total of 48 patients with skeletal Class Ⅱ malocclusion who received orthodontic treatment at the Department of Stomatology, Baoji People's Hospital from January 2022 to January 2023 were selected. All patients underwent CBCT scans 1 week before treatment (T0), 1 month after treatment(T1) and 6 months after treatment(T2). 3D Slicer software was used for modeling, and Geomagic Qualify software was utilized for fitting alignment and measuring the three-dimensional movement distances of various landmarks on the maxilla and mandible. The coordinates of the landmarks at T1 and T2 were compared and analyzed. Pearson correlation analysis was used to determine the correlation between significant relapse landmarks. SPSS 19.0 software package was used for statistical analysis of the data.</p><p><strong>Results: </strong>One month and six months post-treatment, changes in the horizontal coordinate of landmark Rgo and changes in the anteroposterior coordinates of landmarks A, RP, B, Pog, Gn, Me, Rgo and Lgo, as well as changes in the vertical coordinate of Gn were statistically significant(P＜0.05). Correlation analysis revealed a positive correlation between the horizontal movement distance of landmark Rgo from T1 to T0 and the relapse distance(r=0.293, P=0.043). There was a positive correlation between the anteroposterior movement distance of landmark A from T1 to T0 and the relapse distance(r=0.418, P=0.003), a positive correlation between the movement distance of RP from T1 to T0 and the relapse distance (r=0.470, P=0.001), a negative correlation between the movement distance of B from T1 to T0 and the relapse distance(r=-0.523, P=0.000), and a negative correlation between the movement distance of Pog from T1 to T0 and the relapse distance(r=-0.391, P=0.006).</p><p><strong>Conclusions: </strong>Three-dimensional CT reconstruction can provide precise three-dimensional quantitative analysis for the prognostic assessment post-orthognathic surgery in patients with skeletal Class Ⅱ malocclusion. It helps identify landmarks with a high risk of relapse, thus providing more targeted postoperative treatment and monitoring strategies for clinical practice.</p>","PeriodicalId":21709,"journal":{"name":"上海口腔医学","volume":"34 1","pages":"38-42"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144018808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Relationship between maxillary anterior dental arch crowding and alveolar bone morphology, dental arch and alveolar arch morphology in adult females].","authors":"Chuan-Liang Shu, Yu Jiang, Jia Cai","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Purpose: </strong>CBCT was used to measure and analyze the relationship between dental crowding degree and basal bone morphology, dental arch and alveolar arch morphology in adult female maxillary anterior teeth.</p><p><strong>Methods: </strong>A retrospective analysis was conducted on the medical records of 122 adult female patients with maxillary anterior dental arch crowding who received orthodontic treatment at Qingdao Haici Hospital, Affiliated to Qingdao University, from December 2019 to December 2022. The patients were divided into two groups based on the degree of dental arch crowding: group I(mild crowding,maxillary dentition crowding degree ≤ 4 mm, n=62) and group II(moderate to severe crowding,maxillary dentition crowding degree 4-8 mm, n=60). The lengths and widths of the alveolar bones, dental arches and alveolar arches were compared between the two groups. The correlation between dental arch crowding and alveolar bone morphology, dental arch and alveolar arch morphology was analyzed. SPSS 26.0 software package was used for statistical analysis of the data.</p><p><strong>Results: </strong>In group I (mild crowding), the maxillary basal bone length, mandibular basal bone length, maxillary basal bone width at the root apex and root bifurcation,mandibular basal bone width at the root apex and root bifurcation were significantly higher than group II(P＜0.05). The maxillary dental arch length, mandibular dental arch length, maxillary dental arch width,mandibular dental arch width on the mesial and distal sides were significantly higher in group I than group II(P＜0.05). The maxillary alveolar arch length and mandibular alveolar arch length in group I were significantly higher than group II (P＜0.05). There was no significant difference in maxillary alveolar arch width and mandibular alveolar arch width between the two groups(P＞0.05). The crowding degree of the dental arch was negatively correlated with the length of the maxillary and mandibular bases, the width of the maxillary and mandibular bases at the root bifurcation,and the width of the proximal maxillary and mandibular arches(P＜0.05). The length of the maxillary base bone(OR=0.283, 95% CI: 0.128-0.625), the width of the maxillary base bone at the root bifurcation (OR=0.182, 95%CI: 0.083-0.402), the width of the proximal maxillary arch (OR=0.347, 95%CI: 0.158-0.766) and the width of the mandibular arch(OR=0.304, 95% CI: 0.137-0.669) were the influencing factors of dental congestion in the aesthetic area of adult female maxillary anterior teeth(P＜0.05).</p><p><strong>Conclusions: </strong>The reduction of basal bone, dental arch and alveolar arch are associated with crowded dentition in the maxillary anterior aesthetic zone of adult females.</p>","PeriodicalId":21709,"journal":{"name":"上海口腔医学","volume":"34 1","pages":"32-37"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143993260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Genetic analysis and multidisciplinary treatment of a pedigree affected with autosomal dominant hypocalcified amelogenesis imperfecta].","authors":"Meng-Juan Cui, Li Chai, Qiang-Lan Zhai, Zheng-Liang Wang, Tong Xu, Jie-Yi Chen, Chao Liu","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate the pathogenic gene of one Chinese family with autosomal dominant hypocalcified amelogenesis imperfecta and to report multidisciplinary treatment process for two patients from this family, so as to provide guidance for genetic counseling and clinical treatment of hereditary amelogenesis imperfecta.</p><p><strong>Methods: </strong>The clinical data and peripheral blood of the family members were collected. Whole-exome sequencing was performed, and candidate variants were filtered out by data analysis. The identified variant was confirmed by Sanger sequencing and protein three-dimensional structure prediction.</p><p><strong>Results: </strong>Affected members of this hereditary family exhibited yellow-brown discoloration of the dental crowns, rough tooth surfaces, and enamel erosion, consistent with hypocalcified amelogenesis imperfecta. A nonsense mutation c.1363C＞T(p.Gln455*) in exon 5 of the FAM83H gene was identified in the proband, her mother, and her sister; this mutation was predicted to cause a truncation of the FAM83H protein. This variant was not found in unaffected family members. After receiving multidisciplinary treatment based on orthodontics, the proband and her sister restored oral function and aesthetics.</p><p><strong>Conclusions: </strong>The nonsense variant of FAM83H caused hypocalcified amelogenesis imperfecta in this study is detected for the first time in a Chinese family. The results further validate the pathogenic variant involved in FAM83H leading to amelogenesis imperfecta. Patients with amelogenesis imperfecta can restore oral function and aesthetics through various orthodontic and restorative treatments.</p>","PeriodicalId":21709,"journal":{"name":"上海口腔医学","volume":"34 1","pages":"59-67"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144015865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Evaluation of the effect of chair side CAD/CAM all ceramic crowns for restoration of posterior tooth defects].","authors":"Yang Zuo, Xiao-Bo Xu, Lei Liu, Yu-Ting Wang","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate the effect of chair side computer aided design/computer aided manufacturing (CAD/CAM) crown restoration technique in the treatment of posterior tooth defects and its influence on chewing ability.</p><p><strong>Methods: </strong>A total of 98 patients with posterior dental defects treated from June 2023 to May 2024 were selected and divided into control group (traditional silicone rubber impression crown repair) and experimental group (chair side CAD/CAM crown repair) according to different treatment methods. The repair effect, masticatory efficiency and bite force before and after treatment, periodontal index, complication rate and patient satisfaction were compared between the two groups. SPSS 22.0 software package was used for statistical analysis of the data.</p><p><strong>Results: </strong>One month after treatment, there was no significant difference in comfort, edge fit, color matching and surface texture between the experimental group and the control group(P＞0.05). The experimental group was significantly better than the control group in adjacency contact, secondary caries prevention and gingival status (P＜0.05). After treatment,gingival index and plaque buildup, gingival sulcus bleeding index, the degree of gum health improvement of loose tooth in the experimental group were significantly better than in the control group(P＜0.05). There was no significant difference in the incidence of complications between the two groups after treatment(P＞0.05). Repair satisfaction of the experimental group was 96.15%, which was significantly higher than 86.96% of the control group(P＜0.05).</p><p><strong>Conclusions: </strong>Chair side CAD/CAM crown restoration technology has good application value in the treatment of patients with posterior dental defects, which can significantly improve the repair effect, improve chewing ability, effectively inhibit gingival inflammation and dental plaque generation, reduce the risk of gingival bleeding and tooth loosening, and significantly improve patients' satisfaction.</p>","PeriodicalId":21709,"journal":{"name":"上海口腔医学","volume":"34 1","pages":"83-87"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144038488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Efficacy of total crown and porcelain inlay restoration and its effect on masticatory ability and gingival condition].","authors":"Mian Wang, Ying Hou, Fei-Fei Tian, Dan-Jie Meng, Shuang Han","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate the clinical efficacy of full crown and porcelain inlay in the treatment of cracked teeth after root canal treatment and repair and its effect on chewing ability and gingival status.</p><p><strong>Methods: </strong>A prospective study was conducted to select 106 patients with cracked teeth who underwent root canal treatment from December 2020 to December 2023, divided into experimental group and control group according to the random number table method, with 53 cases in each group. The clinical effects and adverse reactions of the two groups were counted and compared. The pain levels [visual analogue scale (VAS)] of the two groups before treatment,1 st, 3 rd and 7 th day after treatment were compared. The gingival conditions [plaque index (PLI), gingival index (GI), gingival bleeding index (BI) and periodontal pocket depth (PD)] were compared between the two groups before treatment and after 6 months of follow-up. The chewing ability (bite force, chewing efficiency) of the two groups before treatment, 1 month, 3 months and 6 months of follow-up were compared.Statistical analysis was performed with SPSS 25.0 software package.</p><p><strong>Results: </strong>The good rate of the experimental group was higher than that of the control group, and the total incidence of adverse reactions was lower than that of the control group(P＜0.05). At the 1st, 3rd and 7th day after treatment, VAS scores of the two groups were significantly lower than those before treatment. The experimental group[(4.43±0.68), (3.15±0.63) and (2.04±0.51) points] were significantly lower than the control group[(4.86±0.57), (3.81±0.67) and (2.86±0.52) points], all showed a downward trend (P＜0.05). At 6 months of follow-up, BI and PD in the two groups were higher than those before treatment, GI and PLI were lower than those before treatment. GI, PLI, BI and PD in the experimental group were significantly lower than those in the control group(P＜0.05). After 1, 3 and 6 months of follow up, the masticatory efficiency and bite force of the two groups were higher than those before treatment. The masticatory efficiency of the experimental group was (70.25±5.57)%, (85.36±6.74)% and (92.57±6.35)%, which was significantly higher than that of the control group[(62.35±5.44)%, (73.57±6.32)% and (84.26±6.22)%]. The bite force in the experimental group[(112.52±9.67), (130.52±11.58) and (143.54±13.40) Ibs] were significantly higher than those in the control group[(98.53±9.47) , (113.25±10.54) and (125.36±12.46) Ibs], all of which showed an upward trend (P＜0.05).</p><p><strong>Conclusions: </strong>The clinical efficacy of porcelain inlays for cracked teeth after root canal treatment and repair is better than that of full crown repair, which can effectively improve the chewing ability and the gingival condition, the incidence of adverse reactions is low.</p>","PeriodicalId":21709,"journal":{"name":"上海口腔医学","volume":"34 1","pages":"88-93"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144045265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Analysis of the aesthetic effect and influencing factors of digital guided implant prosthesis in the treatment of dentition defect].","authors":"Yong Lin, Qing Liu, Jun-Hua Zhang, Xiao-Rong Chang, Dan Hou","doi":"","DOIUrl":"","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Purpose: &lt;/strong&gt;To explore the aesthetic effects and influencing factors of digital guided oral implant restoration in the treatment of dentition defect.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;A total of 168 patients with dentition defect who underwent digital guided dental implant restoration from May 2020 to June 2022 were selected as the experimental group, while 84 patients with dentition defect who underwent routine restoration were selected as the control group. The planting accuracy(neck distance deviation, apical distance deviation, depth deviation and angle deviation), PES score and WES score were compared. The experimental group was divided into good group (n=139) and poor group (n=29) according to the repair effect. Logistic regression analysis was used to analyze the risk factors affecting the therapeutic effect of digital-guided oral implant prosthesis in patients with denture defects, and based on the risk factors, a risk nomogram prediction model for adverse therapeutic effect in patients with denture defects was constructed. Receiver operating characteristic (ROC) curve was drawn to analyze the nomogram to predict the AUC value, sensitivity and specificity of patients with dentition defect. SPSS 22.0 software package was used for statistical analysis.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;The neck distance deviation, root tip distance deviation, depth deviation and angle deviation in the experimental group were significantly lower than those in the control group(P＜0.05). The PES scores and WES scores of the experimental group were significantly higher than those of the control group 6 months after treatment (P＜0.05). There was no significant difference in gender, age, implant, cause of tooth loss, history of hypertension, drinking history, implant diameter, implant length and bone increment surgery between good and poor groups(P＞0.05). There were significant differences in bone mineral density(BMD), diabetes mellitus, smoking history, probe depth and gingival sulcus bleeding index(P＜0.05). Logistic regression analysis showed that grade Ⅲ-Ⅳ bone mineral density(BMD), diabetes history, smoking history, gingival crevicular bleeding index ≥2 were the risk factors affecting the treatment effect of digital guided oral implant repair in patients with dental defect(P＜0.05). ROC curve analysis showed that AUC of nomogram prediction model, bone mineral density of missing teeth, diabetes mellitus, smoking history and gingival sulcus bleeding index in predicting adverse treatment effect of patients with dentition defect were 0.846, 0.725, 0.487, 0.731 and 0.702; the sensitivity was 44.70%, 53.20%, 59.60% and 66.00%,the specificity was 90.20%, 92.20%, 85.60% and 76.50%, respectively.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusions: &lt;/strong&gt;Digital-guided oral implant restoration has a relatively ideal effect in the treatment of dentition defects, which is conducive to improving implant accuracy and aesthetics. However, bone mineral density(BMD), diabetes history, ","PeriodicalId":21709,"journal":{"name":"上海口腔医学","volume":"34 1","pages":"48-53"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144013600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Experimental study of GBE50 on facial nerve after being crushed in rabbits].","authors":"Hai-Bin Lu, Bing-Bing Zhang, Hui Yu, Yu-E Wang, Shu-Jiang Wu, Qiu-Xu Wang","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Purpose: </strong>To compare the regeneration and repair effects of GBE50 and mecobalamin on facial nerve crush injury.</p><p><strong>Methods: </strong>Forty healthy Japan giant ear rabbits were randomly divided into 4 groups,namely GBE50 treatment group, mecobalamin treatment group, normal control group and model control group. Each group contained 10 rabbits. Superior buccal branch of facial nerve cursh injured models were established for 2 treatment groups and model control group, while facial incision was made without crush injuries of facial nerve for normal control group. The treatment group was given GBE50 and mecobalamin respectively, while the control group was only given 1 mL of normal saline, respectively. After 28 days of treatment, rabbits' facial injured beard and orbicularis oris muscle movements were observed, neuroelectrophysiological tests, histomorphological observation, and image analysis were performed, facial nerve regeneration and functional recovery were detected. The data were analyzed by SPSS 22.0 software package.</p><p><strong>Results: </strong>In the model control group, the beard and orbicularis oris muscle movement recovery of rabbits were the worst, but GBE50 treatment group showed better recovery than mecobalamin treatment group. The action potential latency in GBE50 group was lower than the mecobalamin group, and significantly lower than the control group(P＜0.05). The action potential amplitude of GBE50 group was higher than that of mecobalamin group, and significantly higher than the control group(P＜0.05). Image analysis result of never myelinated axons area and axon counts of GBE50 group was higher than that of mecobalamin group, and significantly higher than control group (P＜0.05).</p><p><strong>Conclusions: </strong>GBE50 is superior to mecobalamin in efficacy and speed of facial nerve repair, and it is expected to become another therapeutic drug for rapid and effective treatment of facial nerve injury in clinical practice.</p>","PeriodicalId":21709,"journal":{"name":"上海口腔医学","volume":"34 1","pages":"14-18"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144015741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Changes of saliva flow velocity, total protein and their relationship with dental plaque before and after orthodontic treatment].","authors":"Jie Lei, Kun-Kun Zhu, Feng-Yun DU","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Purpose: </strong>To analyze the relationship between the changes of saliva flow velocity, total protein and dental plaque before and after orthodontic treatment.</p><p><strong>Methods: </strong>The clinical data of 80 patients who received orthodontic treatment in Huaibei Miners General Hospital from May 2021 to February 2024 were retrospectively analyzed.Six months after treatment, the patients were divided into low-level group (n=39) and high-level group (n=41) according to the median plaque index. The clinical data of the high-level group and the low-level group were compared to analyze the influencing factors of high dental plaque index in orthodontic patients. The predictive value of △saliva flow velocity(before treatment -after 6 months of treatment), △total protein and their combination on high dental plaque index in orthodontic patients was analyzed.SPSS 25.0 software package was used for statistical analysis of the data.</p><p><strong>Results: </strong>Six months after treatment, the saliva flow velocity and total protein level of orthodontic patients were significantly lower than before treatment (P＜0.05). The soft scale index, △saliva flow velocity and △total protein level in high-level group were significantly higher than those in low-level group (P＜0.05). Logistic regression analysis showed that △saliva flow velocity(OR=4.604, 95%CI: 2.024-10.474) and △ total protein(OR=3.554, 95%CI: 1.562-8.084) were the influencing factors of high dental plaque index (P＜0.05).The area under the curve (AUC) of △ saliva flow velocity, △total protein and their combination in predicting high dental plaque index in orthodontic patients were 0.803, 0.799 and 0.905 (P＜0.05), respectively, and the AUC value of the combination was higher(P＜0.05).</p><p><strong>Conclusions: </strong>△Saliva flow velocity and △total protein can be used to predict high dental plaque index after orthodontic treatment, and their combination has higher predictive value.</p>","PeriodicalId":21709,"journal":{"name":"上海口腔医学","volume":"34 1","pages":"54-58"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144052714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Effect of gingipain extracts on anxiety-like behavior in mice].","authors":"Xu-Ri Zhao, Yi-Ting Jiang, Yi-Ting Jiang, Li-Na Xu, Zhi-Yan He, Wei Zhou","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Purpose: </strong>To observe the effect of gingipain extracts on anxiety-like behavior in mice.</p><p><strong>Methods: </strong>Gingipain extracts were derived from Porphyromonas gingivalis(P. gingivalis) ATCC33277 by sonication and ultra-speed centrifugation and identified by Western blot and enzyme activity assay. Gingipains infection models were established by intraperitoneal injection of gingipain extracts with/without iodoacetamide (IAM). Enzyme activity assays were used to detect the activity of arginine-gingipain (Rgp) and lysine-gingipain (Kgp) in plasma of mice. Open field experiments and elevated zero maze experiments were used to detect anxiety-like behavior in mice. Immunofluorescence staining of brain tissue slices was used to observe changes in astrocytes of the brain. GraphPad Prism software was used for statistical analysis.</p><p><strong>Results: </strong>The gingipain extracts were collected from P. gingivalis ATCC33277 and they showed Rgp and Kgp activity. The activity of Rgp and Kgp could be detected in mice plasma after intraperitoneal injection of gingipain extracts. Compared with the control group, there were no significant changes in the autonomous activity ability of the gingipain group mice. In the open field experiment, the central area staying time of the gingipain groups was significantly reduced(P＜0.05). In the elevated zero maze experiment, the open area frequency of the gingipain groups was obviously shortened(P＜0.05). Anxiety-like behavior was significantly enhanced. Immunofluorescence staining showed that gingipain extracts could significantly activate astrocytes in the hippocampus of mice. The above results could be significantly alleviated by gingipain inhibitor IAM.</p><p><strong>Conclusions: </strong>Gingipain extracts could induce anxiety-like behavior in mice, which may be related to neuroinflammation due to activation of astrocytes.</p>","PeriodicalId":21709,"journal":{"name":"上海口腔医学","volume":"34 1","pages":"1-6"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144042345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}