上海口腔医学最新文献

{"title":"[Comparison of the effect of A-PRF and CGF on the recovery of mandibular impacted third molar after extraction and on alveolar ridge of the adjacent second molar].","authors":"Li-Li Pu, Chun-Hui Chen, Xi Tong","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Purpose: </strong>To compare the recovery effect of advanced platelet-rich fibrin (A-PRF) and concentrated growth factor (CGF) in the treatment of mandibular impacted third molar(M3) extraction, and the effect on alveolar ridge of the adjacent second molar(M2).</p><p><strong>Methods: </strong>A total of 150 patients who received mandibular impacted M3 extraction in Jinhua Central Hospital from September 2020 to August 2021 were included. Among them, group A (n=49) received conventional suture, group B (n=51)received conventional suture +A-PRF filling, and group C(n=50) received conventional suture +CGF filling. Postoperative clinical indexes, soft tissue healing, alveolar bone density changes and M2 alveolar ridge height changes were compared among the three groups. Meanwhile, complications and adverse reactions were recorded and compared among the three groups. SPSS 20.0 software package was used for data analysis.</p><p><strong>Results: </strong>One week after surgery, the pain degree and swelling degree of the three groups were lower than before treatment(P＜0.05), and group B ＜ group C ＜ group A(P＜0.05). Mouth opening degree was higher than before treatment(P＜0.05), group B ＞ group C ＞ group A (P＜0.05), and the soft tissue healing condition of group B was better than that of group C, and than that of group A(P＜0.05). At 6 weeks and 12 weeks after surgery, the alveolar bone mineral density of the three groups was higher than that immediately after surgery(P＜0.05), and group B ＞ group C ＞ group A(P＜0.05). There were significant differences between group B and C at 6 weeks and 12 weeks after surgery (P＜0.05). The M2 alveolar ridge height (ΔH) 12 days after surgery was lower than that immediately after surgery(P＜0.05), and group B and C was lower than that of group A (P＜0.05). The incidence of complications such as bleeding, infection, dry socket, nerve injury and periodontal pus discharge in group B ＜ group C ＜ group A, and the incidence of complications was statistically significant(P＜0.05).</p><p><strong>Conclusions: </strong>The effects of A-PRF and CGF on M2 alveolar ridge and postoperative adverse reactions are similar, but A-PRF is better than CGF in improving clinical symptoms and promoting postoperative recovery in maxillary impacted M3 patients, with fewer complications, and is worthy of clinical promotion.</p>","PeriodicalId":21709,"journal":{"name":"上海口腔医学","volume":"34 1","pages":"94-99"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144007197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Finite element simulation of distally moving mandibular molars by sequence with clear aligner].","authors":"Fu-Jia Kang, Yu-Chen Cui, Song-Qing Wang, Yu-Miao Wu, Lei Yu, Xian-Chun Zhu","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Purpose: </strong>To construct a finite element model of the mandibular molars distalization with clear aligner, and to explore the characteristics of dentition movement and aligner deformation.</p><p><strong>Methods: </strong>The models of mandible, teeth, periodontal membrane and clear aligne were constructed using CBCT and oral scan data, and were divided into 8 groups according to the starting position of the second and first molar teeth. Working condition 1-4: the distance between the second molar and the first molar was 0, 1, 2, 3 mm, respectively. Working condition 5-8: the second molar had moved far to the target position of 3.2 mm, and the distance between the first molar and the second premolar was 0, 1, 2 and 3 mm, respectively. \"Two-step method\" was used to simulate the loading of the clear aligner and set the distance of the step to 0.2 mm, the characteristics of dental displacement and appliance shape change in each working condition were analyzed.</p><p><strong>Results: </strong>Under each working condition, the molar with pseudo-remote displacement showed tilt movement of the crown to the far, and the other teeth showed reverse tilt movement. As the initial position of the pseudo-distant molar changed to the distal, the distal movement of the pseudo-distant molar increased. In working condition 4, the maximum displacement of the second molar was 0.11 mm, and in working condition 8, the maximum displacement of the first molar was 0.10 mm. The change trend of the Von Mises equivalent stress value of the periodontal membrane of the pretended distalization teeth was similar to that of the displacement.</p><p><strong>Conclusions: </strong>Clear aligner can complete distal movement of molar teeth, but the amount of movement cannot reach the expected value. As the initial position of the molars changed to the distal, the distance displacement will increase.</p>","PeriodicalId":21709,"journal":{"name":"上海口腔医学","volume":"34 1","pages":"19-24"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144019938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Gene expression profiling analysis of stress-sensitive genes and their potential functions in myoblasts].","authors":"Yao Zheng, Shao-Yang Yu, Xiao Yan, Jian-Ping Li, Qiang Zhang, Xiao Yuan","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Purpose: </strong>To screen the stress-sensitive genes in myoblasts and reveal the potential target genes and their regulatory mechanisms of facial muscle remodeling induced by functional orthopaedic force.</p><p><strong>Methods: </strong>The procedure involved the use of gene microarray technology to identify the differentially expressed genes(DEGs) in myoblasts. DEGs were then categorized by Gene Ontology(GO) and Kyoto Encyclopedia of Genes and Genomes(KEGG) enrichment analyses. Furthermore, real-time quantitative PCR(qRT-PCR) was used to verify the DEGs. Western blot, transmission electron microscopy(TEM), and confocal laser scanning microscope(CLSM) were employed to detect the effect of stress on autophagy in myoblasts. The data were analyzed by SPSS 17.0 software package.</p><p><strong>Results: </strong>A total of 1 410 DEGs were identified in stretched myoblasts, with 788 up-regulated and 622 down-regulated genes. GO enrichment analysis indicated that DEGs were primarily involved in signal transduction, biopolymer metabolic process, and protein metabolic process. KEGG analysis revealed that DEGs were primarily associated with ECM-receptor interaction, pathway in cancer, MAPK signaling pathway, focal adhesion and lysosome. Both TEM and CLSM showed that stress could promote the formation of autophagosomes, and Western blot demonstrated that stress could promote the expression of autophagy-related molecules Beclin-1 and LC3-II. Rapamycin could enhance all the above processes, while 3-MA could inhibit them.</p><p><strong>Conclusions: </strong>Autophagy may play an important role in the regulation of myoblast fate induced by cyclic tensile stress.</p>","PeriodicalId":21709,"journal":{"name":"上海口腔医学","volume":"34 1","pages":"7-13"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143998105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Evaluation of autologous fat grafting in improving post-treatment skin fibrosis in 20 patients with oral cancer].","authors":"Yu Wang, Zhen Qian, Li-Li Li-Li, Ming-Yi Wang","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the clinical effect of autologous fat grafting for treating cervical skin fibrosis in patients with oral cancer after neck dissection with or without radiotherapy.</p><p><strong>Methods: </strong>A total of 20 patients who underwent oral cancer resection and neck dissection in Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine from October 2022 to July 2023 were enrolled, 7 patients were treated with radiotherapy after neck dissection and 13 patients were treated with neck dissection. According to the degree of face-neck depression, the range of fibrosis and the function of neck and shoulder, corresponding volume of autologous fat was used to fill the depression. Three months after treatment, the improvement of cervical skin fibrosis was evaluated in terms of scar improvement, shoulder and neck function, and quality of life. SPSS 26.0 software package was used for statistical analysis of the data.</p><p><strong>Results: </strong>The interval between the treatment of oral cancer and fat filling was 11-72 months, and the dose of fat grafting was 15-45 mL. There were no complications such as local induration, infection and necrosis in all patients. Three months after treatment, the results of Constant-Murley Score(CMS), neck fibrosis symptom(VAS), patient observer scar assessment scale(PSAS, OSAS) and FACE-Q quality of life score were better than those before treatment, and the differences were statistically significant(P＜0.05).</p><p><strong>Conclusions: </strong>Autologous fat grafting can significantly improve the fibrosis of the neck skin after neck dissection with or without radiotherapy, and improve shoulder and neck dysfunction caused by surgery and radiotherapy. This method is worthy of clinical used because of the low rate of complication.</p>","PeriodicalId":21709,"journal":{"name":"上海口腔医学","volume":"34 1","pages":"68-73"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144024774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Application effect of A-PRF and CGF combined with nano-hydroxyapatite in external maxillary sinus lift implantation].","authors":"Bing-Yao Liu, Xiao-Dong Yu, Cui-Mei Li, Wei-Hua Shang","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the clinical efficacy of advanced platelet-rich fibrin(A-PRF) and concentrated growth factor(CGF) combined with nano-hydroxyapatite in external maxillary sinus lift implantation.</p><p><strong>Methods: </strong>A total of 68 patients who underwent external maxillary sinus lift implantation from April 2023 to March 2024 at Taikang Xianlin Gulou Hospital were selected. They were randomly assigned to the control group(n=34, using Bio-Oss large particle bone graft material) and combined group(n=34, using A-PRF and CGF combined with nano-hydroxyapatite). Postoperative symptoms, bone levels, wound healing status, stability coefficient, mucosal healing, and complications were compared between the two groups. SPSS 27.0 software package was used for statistical analysis of the data.</p><p><strong>Results: </strong>At 1 month and 3 months after operation, the conscious symptom score in combination group was significantly lower than that in the control group (P＜0.05), bone mineral density, bone increment and bone height at 6 months after operation were significantly lower than those in the control group; ISQ value, keratinized gingiva width and thickness were significantly higher than those in the control group (P＜0.05). The primary healing rate I in combination group was higher than that in the control group, and the healing time was lower than that in the control group(P＜0.05). There was no significant difference in the occurrence of adverse events between the combined and control groups(P＞0.05).</p><p><strong>Conclusions: </strong>The combination of A-PRF and CGF with nano-hydroxyapatite significantly improves bone quality, enhances implant stability, and accelerates postoperative recovery in external maxillary sinus lift implantation.</p>","PeriodicalId":21709,"journal":{"name":"上海口腔医学","volume":"34 1","pages":"43-47"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144037734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[CBCT study on the measurement of occlusal plane and molars in adolescent patients with Class Ⅱ subdivision malocclusion].","authors":"Yuan-Feng Ding, Ying-Yuan Sun, Su-Ying Guo, Qing-Qing Li, Li-Juan Song","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Purpose: </strong>To study the CBCT imaging features of occlusal plane inclination, molar inclination, and molar height in adolescent patients with Class Ⅱ subdivision malocclusion, in order to provide reference for clinical diagnosis and treatment.</p><p><strong>Methods: </strong>A total of 80 adolescent patients with malocclusion admitted to Suzhou Stomatological Hospital from January 2019 to December 2022 were selected, including 40 cases of Class Ⅱ subdivision malocclusion as the experimental group and 40 cases of Class Ⅰ malocclusion as the control group. The angles of the anterior, posterior and maxillary occlusal planes, as well as the inclination of the upper and lower molars in the mesial and distal direction, the inclination of the buccal and lingual direction, and the height of the molars were analyzed based on CBCT data. SPSS 23.0 software package was used for data analysis.</p><p><strong>Results: </strong>There were significant differences in the angles of the neutral and distal anterior, posterior and maxillary occlusal planes, as well as the height of the upper and lower molars between the experimental group of patients with Class Ⅱ subdivision malocclusion(P＜0.05); There was no significant difference in the inclination of the upper and lower molars in the mesial and distal direction, as well as in the inclination of the buccal and lingual directions(P＞0.05). There was no significant difference in the comparison of left and right measurements in the control group(P＞0.05). The angles of the anterior, posterior and maxillary occlusal planes in the experimental group were significantly negatively correlated with the inclination of the maxillary molars in the mesiodistal and buccal lingual direction(P＜0.01), and negatively correlated with the height of the molars(P＜0.05).</p><p><strong>Conclusions: </strong>Patients with Class Ⅱ subdivision malocclusion may have differences in the angles of the posterior, anterior, and maxillary occlusal planes, as well as the height of the upper and lower molars, compared to Class Ⅰ malocclusion patients. In clinical orthodontic treatment, it is necessary to be vigilant for such patients, trying to choose appropriate treatment opportunities, and reasonable treatment plans to prevent malocclusion from developing towards a more severe direction.</p>","PeriodicalId":21709,"journal":{"name":"上海口腔医学","volume":"34 1","pages":"100-105"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144061594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Research progress and current situation of oral surgery robots based on published papers and patents analysis].","authors":"Zhi-Fan Zhang, Zhi-Qun Shu, Feng Xu, Hui-Qing Shen","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Purpose: </strong>To analyze the research progress and technological development of oral surgery robots, reveal the future development trend of oral surgery robots and put forward policy suggestions.</p><p><strong>Methods: </strong>Focusing on the topic of oral surgery robots, literature review and patent data retrieval methods were used to analyze data from 2011 to 2023 from the perspectives of quantity, source, and technical field.</p><p><strong>Results: </strong>The number of academic papers and patent applications in the field of oral surgery robots had explosive growth since 2015. The literature mainly focused on topics such as oral implantation and digitalization, with Chinese scholars publishing the most papers. The patents focused on tools such as models and instruments dedicated to oral surgery, as well as technical fields such as implant visual navigation and positioning systems.</p><p><strong>Conclusions: </strong>Oral surgery robots should be developed towards miniaturization and specialization in the future, and domestic breakthroughs in core technologies such as special instruments need to be accelerated.</p>","PeriodicalId":21709,"journal":{"name":"上海口腔医学","volume":"34 1","pages":"106-112"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143998231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Screening of characteristic genes of salivary gland adenoid cystic carcinoma based on weighted co-expression network and machine learning].","authors":"Wen-Chao Bu, Shi-Xin Chen, Yin-Hua Jiang, Ming-Guo Cao, Xin-Ru Wu, Yun-Qian Guan, Si-Yuan Xie","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Purpose: </strong>To identify potential biomarkers of salivary gland adenoid cystic carcinoma to further understand the potential pathogenesis of adenoid cystic carcinoma.</p><p><strong>Methods: </strong>Two microarray datasets (GSE59701, GSE88804) were downloaded from NCBI GEO database. LIMMA software package was used to screen SACC differentially expressed genes. WGCNAs were used to find the important module genes that were most associated with SACC. Two machine learning methods(LASSO and SVM-RFE) were used to identify Hub genes. Subsequently, ROC curve used to predict SACC was developed to determine the diagnostic effect. R4.2.1 software was used for statistical analysis.</p><p><strong>Results: </strong>Three hub genes(GABBR1, EN1 and LINC01296) were identified, and a ROC curve with high predictive performance (AUC, 1.000-1.000) was established.</p><p><strong>Conclusions: </strong>Three hub genes(GABBR1, EN1 and LINC01296) were obtained by WGCNA, LASSO, SVM-RFE as potential biomarkers of SACC, and the findings of this study provide a foothold for future research on potential key genes of SACC, and a target basis for the early diagnosis and treatment of SACC.</p>","PeriodicalId":21709,"journal":{"name":"上海口腔医学","volume":"33 6","pages":"600-607"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143504161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Study on the effects of improved shield technique in the aesthetic zone for single tooth implantation in the maxillary anterior region].","authors":"Zhong-Yue Hu, Wei Niu, Dai-Yuan Chen, Jin-Yang Zou, Hui Xie","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Purpose: </strong>To explore the effects of improved shield technique in the aesthetic zone for single tooth implantation in the maxillary anterior region.</p><p><strong>Methods: </strong>Eighty-four patients(84 teeth) who underwent single tooth implantation in the maxillary anterior region from January 2020 to January 2023 were selected,randomly divided into the control group and experimental group using digital table method, each with 42 patients(42 teeth). The success rate of implant in 2 groups was recorded, and periodontal index, pink esthetic score (PES), bone absorption and implant stability quotient (ISQ) preoperatively and 6 months after surgery were compared. The incidence of adverse reactions (redness, bleeding, pain and site infection) was recorded. SPSS 26.0 software package was used for statistical analysis of the data.</p><p><strong>Results: </strong>The success rate of implantation in both groups was 100%. Six postoperative pericrescent indexes of the experimental group were significantly lower than that of the control group, PES and ISQ scores of the experimental group were significantly higher than that of the control group one year after surgery, bone absorption volume was significantly lower than that of the control group and the incidence of adverse reactions was significantly decreased(P＜0.05).</p><p><strong>Conclusions: </strong>The improved shield technique in the aesthetic zone can enhance the esthetic index and implant stability in the anterior region, and reduce bone resorption volume.</p>","PeriodicalId":21709,"journal":{"name":"上海口腔医学","volume":"33 6","pages":"651-655"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143504168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Analysis of periodontal health status and influencing factors of elderly people in Jiading District of Shanghai].","authors":"Yu-Hong Tang, Qian Zhu, Zhao Wu, Xing Ran","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate the periodontal health status and influencing factors of the elderly aged 65-74 years in Jiading District of Shanghai, and to provide data support for periodontal prevention and health care for the elderly in Jiading District.</p><p><strong>Methods: </strong>A total of 961 elderly people aged 65-74 years old in Jiading District were selected by multi-stage, stratified, equal size and random sampling method, and oral examination and questionnaire survey were conducted. SPSS 22.0 software package was used for descriptive statistics and multivariate logistic regression analysis.</p><p><strong>Results: </strong>Among 961 elderly people, the detection rate of periodontal pockets, bleeding on gingival probing, dental calculus and debris were 58.9%, 85.3%, 90.5% and 88%, respectively. The mean number of missing teeth was 6.25±5.94. The average number of gingival index, calculus index and debris index were 1.82±0.706, 1.26±0.632, 1.17±0.620, respectively. The results of univariate analysis showed that gender, education level, smoking, diabetes, cardiovascular disease, oral hygiene habits (frequency of brushing teeth and frequency of cleaning teeth) were risk factors for periodontitis in the elderly in Jiading District. Multivariate logistic regression analysis showed that smoking, diabetes and oral hygiene habits (tooth cleaning frequency) were independent risk factors for periodontitis in the elderly in Jiading District.</p><p><strong>Conclusions: </strong>The periodontal health status of the elderly aged 65-74 years in Jiading District is poor, and comprehensive prevention and treatment from various aspects and links should be carried out.</p>","PeriodicalId":21709,"journal":{"name":"上海口腔医学","volume":"33 6","pages":"642-646"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143503997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}