上海口腔医学最新文献

{"title":"[Myogenic induction activity and mechanism of rhein in aged mouse myoblasts C2C12 cell line].","authors":"Cancan Pan, Lei Qi, Jiawen Si, Guofang Shen","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Purpose: </strong>To establish an in vitro model of aged murine myogenic cell line C2C12, clarify rhein's anti-inflammatory function, and explore its effects on myogenic induction activity and related immunomodulatory mechanisms in aged C2C12 cells.</p><p><strong>Methods: </strong>CCK-8 assay was used to assess cell proliferation rates of C2C12 cells pretreated with different concentrations of hydrogen peroxide(H₂O₂) for varying duration. Real-time quantitative reverse transcription PCR (RT-qPCR) was employed to observe myogenic and aged-related gene expression changes. The expression of reactive oxygen species(ROS) and senescence-associated β-galactosidase (SA-β-gal) was measured. Immunofluorescence was used to compare the diameter of the formed myotubes. The effects of different concentrations of rhein(0, 1, 2, 4, 8, 16, 32 μmol/L) on the proliferation of murine macrophage cell line RAW264.7 over 3 days were measured using CCK-8 assay. The expression of polarization-related factors in RAW264.7 cells was detected by RT-qPCR and immunofluorescence. The effects of macrophage-conditioned medium(CM) induced by rhein on myogenic function and age-related phenotypes in aged C2C12 cells were explored through experiments including RT-qPCR to detect relevant gene expression, ROS and SA-β-gal staining, and immunofluorescence staining.</p><p><strong>Results: </strong>Compared with the control group, treatment of C2C12 cells with 200 and 400 μmol/L H₂O₂ for 24 hours significantly reduced the proliferation ability of C2C12 without causing apoptosis, increased the expression of age-related genes, ROS, and SA-β-gal, decreased the expression of myogenic genes, and inhibited myotube formation, with more pronounced effects at 400 μmol/L(P＜0.05). Rhein at a concentration of 1 μmol/L was non-cytotoxic to RAW264.7 cells, reduced the expression of M1-related phenotypes (TNF-α, IL-1β, iNOS, IL-6), and promoted the expression of M2-related phenotypes (IL-1Ra, CD206)(P＜0.05). Macrophage-conditioned medium (CM) induced by rhein enhanced the expression of myogenic genes in aged C2C12 cells, increased the diameter of myotube, and reduced the expression of age-related genes, ROS, and SA-β-gal(P＜0.05).</p><p><strong>Conclusions: </strong>An in vitro model of aged muscle stem cells can be established using H2O2. Rhein can enhance the myogenic capacity of aged muscle, likely through the regulation of macrophage M2 polarization.</p>","PeriodicalId":21709,"journal":{"name":"上海口腔医学","volume":"35 1","pages":"19-28"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147609724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Exploration of the role of LncRNA PVT1 targeting miR-18b-5p in the differentiation of dental pulp mesenchymal stem cells into dentin].","authors":"Yu Zheng, Tong Zhai, Min Cui, Fei Liu","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Purpose: </strong>To analyze on the role of long-chain non coding ribonucleic acid (LncRNA) plasmacytoma variant translocation 1 (PVT1) in the differentiation of dental pulp mesenchymal stem cells (DPMSCs) into dentin by targeting microribonucleic acid 18b-5p(miR-18b-5p).</p><p><strong>Methods: </strong>Human DPMSCs were isolated and cultured, then identified by staining with oil red O, Alizarin red, and Alisin blue, and detected cell surface marker molecules by flow cytometry. Inoculate cells onto a 24 well plate, 2×104/cm2 density, grouping, including PVT1 upregulation+miR-18b-5p downregulation group (transfected with pcDNA-PVT1 and antomiR-18b-5p), PVT1 downregulation+miR-18b-5p upregulation group (transfected with si-PVT1 and agomiR-18b-5p), empty 1 group (transfected with NC pcDNA), empty 2 group (transfected with ago-NC), PVT1 upregulation + empty 2 group (transfected with pcDNA-PVT1 and empty 2). empty1+miR-18b-5p downregulation group (transfected with empty1 and antomiR-18b-5p) and a blank group. After 7 days, Alizarin red staining was used to observe the calcium mineralization of cells, and alkaline phosphatase (ALP) activity was detected using a reagent kit. Real time fluorescence quantitative polymerase chain reaction(RT-qPCR) was used to detect the expressions of LncRNA PVT1, miR-18b-5p, dentin salivary phosphoprotein(DSPP), osteocalcin(OCN), and Runt related transcription factor 2 (RUNX2) genes in each group. Western blot(WB) was used to detect the expressions of DSPP, OCN, and RUNX2 proteins in each group. Dual luciferase reporter gene detection experiment was used to explore the targeting relationship between LncRNA PVT1 and miR-18b-5p.</p><p><strong>Results: </strong>This study successfully isolated human DPMSCs and identified them by staining with oil red O, Alizarin red, Alishin blue and flow cytometry. The PVT1 upregulation+miR-18b-5p downregulation group had the strongest dentin differentiation activities (P＜0.05), while that of PVT1 downregulation+miR-18b-5p upregulation group was the weakest(P＜0.05). The LncRNA PVT1, DSPP, OCN and RUNX2 expressions were highest in the PVT1 upregulation+miR-18b-5p downregulation group(P＜0.05), while miR-18b-5p expression was lowest (P＜0.05). The PVT1 downregulation+miR-18b-5p upregulation group showed the opposite trend(P＜0.05). There were binding sites between LncRNA PVT1 and miR-18b-5p, and LncRNA PVT1 could negatively feedback and target miR-18b-5p.</p><p><strong>Conclusions: </strong>Upregulation of LncRNA PVT1 can target the inhibition of miR-18b-5p and promote the differentiation of human DPMSCs into dentin, which may be related to the upregulation of DSPP, OCN and RUNX2 expressions.</p>","PeriodicalId":21709,"journal":{"name":"上海口腔医学","volume":"35 1","pages":"35-41"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147609730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Oral health management for patients during the peri-orthodontic treatment period].","authors":"Yazhen Li, Bin Yan, Yuehua Liu, Jianguang Xu, Jiejun Shi, Huang Li, Zhengwei Huang, Zhongchen Song, Yongming Li, Jianyong Wu, Jie Pan, Guohua Tang, Ning Zhao, Weibing Zhang, Tingting Wu, Xi Chen, Yaqin Zhu, Bing Fang, Lunguo Xia","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Oral health management during orthodontic treatment is crucial for ensuring the effectiveness of the treatment. Proper oral health management can accelerate the orthodontic process, alleviate adverse reactions, and improve quality of life. Currently, there is a lack of systematic and comprehensive guidance on oral health management for patients undergoing orthodontic treatment both domestically and internationally. To further standardize oral health management during the orthodontic period, this paper summarized relevant literature from home and abroad through discussions among experts, established health management protocols for fixed, invisible, and functional orthodontics, aiming to provide references and guidance for orthodontists and patients.</p>","PeriodicalId":21709,"journal":{"name":"上海口腔医学","volume":"35 1","pages":"1-6"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147609735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Effect of Trifolium repens extract on OSC-4 cell proliferation, apoptosis and NLRP3/PRKD3 protein level].","authors":"Dan Yang, Minghui Lei, Jie Wang, Xiaoting Ji, Kai Song, Bin Liu","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate the effects of Trifolium repens extract on proliferation, apoptosis, invasion and NLRP3/PRKD3 protein levels of oral squamous cell carcinoma cell line OSC-4.</p><p><strong>Methods: </strong>The OSC-4 cells were randomly divided into SO group (OSC-4 cells were cultured without adding Trifolium repens extract), SA group (OSC-4 cells were cultured with 1 mg/mL Trifolium repens extract), SB group(OSC-4 cells were cultured with 5 mg/mL Trifolium repens extract), and SC group(OSC-4 cells were cultured with 10 mg/mL Trifolium repens extract). MTT was used to detect cell proliferation, flow cytometry was used to detect cell apoptosis, Transwsll chamber assay was used to evaluate cell invasion, Western blot and PCR were used to detect the expression of NLRP3/PRKD3.</p><p><strong>Results: </strong>Compared with SO group, the expression of NLRP3 and PRKD3 mRNA in SA group, SB group and SC group were significantly reduced, and the degree of reduction was in order of SC group＞SB group＞SA group(P＜0.05). There was no significant difference in the inhibition rate of cell proliferation in each group at 0 h(P＞0.05). At 48 h, the proliferation inhibition rate of SA group, SB group, and SC group was significantly higher than that of SO group(P＜0.05). There was significant difference in the apoptosis rate of OSC-4 cells in each group (P＜0.001). The apoptosis rate of OSC-4 cells in SA group, SB group and SC group was significantly higher than that in SO group(P＜0.05). There was significant difference in the number of OSC-4 cell invasion in each group(P＜0.001). The number of OSC-4 cell invasion in SA group, SB group and SC group was significantly lower than that in SO group(P＜0.05). The differences in the expression of NLRP3 and PRKD3 protein in each group was significant(P＜0.001). The NLRP3 and PRKD3 proteins of SA group, SB group and SC group were significantly lower than those of SO group (P＜0.05).</p><p><strong>Conclusions: </strong>Sanye green extract can inhibit OSCC cell proliferation and invasion, promote its apoptosis. Its mechanism of action may be related to the regulation of NLRP3/PRKD3 expression.</p>","PeriodicalId":21709,"journal":{"name":"上海口腔医学","volume":"35 1","pages":"29-34"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147609711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Quadratic correlation analysis between cephalometric measurements and facial profile attractiveness].","authors":"Xiaofan Feng, Xin Chen, Hongyu Ren","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Purpose: </strong>To explore the nonlinear quadratic relationship between cephalometric measurements and facial attractiveness.</p><p><strong>Methods: </strong>Photographs were used by 16 laypersons to rate the attractiveness of 180 adult patients without orthodontic treatment.The quadratic correlation between 37 cephalometric measures(obtained from lateral cephalograms) and facial attractiveness was calculated, and the maximum attractiveness values(MAVs) for significant cephalometric measures were identified.</p><p><strong>Results: </strong>Nineteen measures demonstrated significant quadratic correlations with facial attractiveness, with r values from 0.203 to 0.529. The top 12 parameters that had a significant quadratic correlation with facial attractiveness were ANB angle (r = 0.529, MAV = 2.3°), NA-APo (0.505, 3.9°), G'-Sn-Pog' (0.467, 11.1°), UL-EP (0.440, -0.3 mm), Wits (0.415, 0.1 mm), facial angle (0.374, 89.1°), FMIA (0.374, 63.6°), Pog' to G Vert (0.374, 0.7 mm), N' Vert-Pog'(0.368, 4.2 mm), SNB(0.367, 79.2°), L1-NB (0.346, 5.3 mm) and L1-NB (0.340, 25.2°), respectively.</p><p><strong>Conclusions: </strong>The protrusion of the upper lip and the anteroposterior position of the mandible may be the primary cephalometric parameters related to subjective facial profile perceptions. The position of the lower incisor contributed more to facial attractiveness than the upper incisor. It is noteworthy that the normal values for most cephalometric measurements differ significantly from the MAV, indicating that these normal values do not accurately reflect facial attractiveness.</p>","PeriodicalId":21709,"journal":{"name":"上海口腔医学","volume":"35 1","pages":"77-82"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147609770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Study on the correlation and joint prediction model of age, dental age and cervical spine age among Uyghur children and adolescents in Xinjiang region].","authors":"Tursun Kaiwusaier, Yuxin Shi, Lina Zhang, Jia Liu","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Purpose: </strong>To explore the correlation between the actual age, dental age and cervical vertebral bone age in Uygur children and adolescents in Xinjiang region, and to construct the regression equation and joint prediction model of cervical vertebral bone age for males and females to improve the accuracy of age estimation.</p><p><strong>Methods: </strong>This study was conducted in two phases. In the first stage, the data of full mouth surface tomography and skull localization lateral radiographs of 320 Uygur children and adolescents aged 8-15 years were collected. The dental age was inferred by Willems method, and the third and fourth cervical vertebrae were measured by Mito cervical vertebrae osteometry. The cervical spine bone age measurement data of 224 samples (112 males and 112 females) were randomly selected for multiple stepwise regression analysis. The cervical spine bone age prediction equations for males and females were established respectively, and verified with the remaining 96 samples (48 males and 48 females). In the second stage, the cervical spine age of all samples was calculated based on the regression equation constructed in the first stage. Subsequently, Spearman correlation coefficient was used to analyze the correlation between chronological age, dental age and cervical spine bone age, and further multiple regression analysis was performed to evaluate the predictive effect of dental age and cervical spine bone age on chronological age. Finally, all the sample data were collected and combined multiple regression analysis was carried out to construct a comprehensive age prediction model.</p><p><strong>Results: </strong>The cervical spine bone age equation established through multiple stepwise regression analysis was: male cervical spine bone age=-1.189+16.607×H4/D4+9.064×AP3/H3+5.369×H4/AH4(R=0.875); female cervical spine bone age=0.233+7.084×AH4/AP4+26.048×h4/H4+4.650×AH3/PH3(R=0.868). Spearman correlation analysis results showed that the correlation coefficient between chronological age and dental age was r=0.956, the correlation coefficient between chronological age and cervical spine bone age was r=0.871, and the correlation coefficient between dental age and cervical spine bone age was r=0.843, all of which showed significant positive correlation(P＜0.01). The unified regression model constructed by the joint analysis further improved the prediction accuracy, and the R2 of the model was 0.916. The final formula of the combined model was: actual age=-1.064+0.753× tooth age +0.325× cervical bone age.</p><p><strong>Conclusions: </strong>Through joint analysis of dental age and cervical bone age, this study significantly improves the prediction accuracy of actual age, and successfully constructs a unified prediction model suitable for Uyghur children and adolescents aged 8-15 years in Xinjiang region, providing an efficient and reliable tool for age inference in the region.</p>","PeriodicalId":21709,"journal":{"name":"上海口腔医学","volume":"35 1","pages":"48-53"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147609738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Investigation on deciduous dental caries among school children aged 6-11 years in Xuhui District of Shanghai].","authors":"Xinyu Meng, Yipei Wu, Hongru Su, Jinming Yu","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate the prevalence of dental caries in primary teeth among school-age children through oral health examination of 8 primary schools in Xuhui District of Shanghai, and to provide a scientific basis for the prevention and control of caries.</p><p><strong>Methods: </strong>A multi-stage cluster sampling method was used to select 11 344 school-age children aged 6-11 from eight public elementary schools in Xuhui District, Shanghai, as the survey subjects. Oral examinations were conducted according to the protocol of the Fourth National Oral Health Epidemiological Survey. The incidence of caries and the decayed, missing, and filled teeth(DMFT) index were analyzed by SAS 9.4 software package.</p><p><strong>Results: </strong>The caries prevalence among the 11 344 school-age children was 30.61%, with a mean DMFT score of 0.97±1.96. The caries prevalence in primary teeth was 25.43%, with a mean DMFT score of 0.85±1.87; while the caries prevalence in permanent teeth was 7.58%, with a mean DMFT score of 0.12±0.47. There was no statistically significant difference in caries prevalence and DMFT scores of primary teeth between boys and girls. However, girls had a higher caries prevalence and DMFT score in permanent teeth compared to boys, and the differences were statistically significant(P＜0.05). In different age groups, the caries prevalence in primary teeth initially increased with age and then decreased, with 8-year-old children having the highest prevalence. The caries prevalence in permanent teeth increased with age, and the differences were statistically significant(P＜0.001). Regarding the position of the caries, the most affected primary teeth were the maxillary primary central incisors, primary molars, and mandibular primary molars; while the first permanent molars were the most affected permanent teeth.</p><p><strong>Conclusions: </strong>The prevalence of dental caries in both primary and permanent teeth among school-age children in Xuhui District of Shanghai is relatively high, and the affected teeth are concentrated. Early prevention and control of dental caries in school-age children should be strengthened.</p>","PeriodicalId":21709,"journal":{"name":"上海口腔医学","volume":"35 1","pages":"95-100"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147609762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Effect of chemical combined with mechanical selective caries removal on the treatment of deep caries].","authors":"Danjie Meng, Cong Fan, Yongzheng Dai, Yingze Yang, Yiwen Zhou, Rui Tao","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Purpose: </strong>To observe the effect of different endpoints in chemical-mechanical caries removal for deep caries on the labial-buccal surface, and to provide reference for the selection of treatment methods and indications.</p><p><strong>Methods: </strong>A total of 41 teeth diagnosed with deep caries and undergoing selective caries removal treatment were selected. According to the study criteria, chemical- mechanical decayed dentin, decayed dentin to toughened dentin (SRFD group) and decayed dentin to softened dentin(SRSD group) were recorded, and one-step filling was performed. The pulp activity, secondary caries, edge integrity, surface status, edge discoloration and cold irritation response of the affected tooth were observed and analyzed after 6 months.</p><p><strong>Results: </strong>There was no significant difference between the two groups in the edge integrity, edge discolorimetry, surface status, secondary caries, cold irritation response and pulp activity 6 months after surgery(P＞0.05). There was significant difference between 3 months and 6 months after operation in the SRSD group (P＜0.05).</p><p><strong>Conclusions: </strong>There is no significant difference in the therapeutic effect of deep caries teeth treated by chemical-mechanical caries removal at different caries removal endpoints after 6 months of treatment, and there is no significant difference in the effect of decay endpoints on pulp electrical activity values. The effect of softening dentin by caries removal on pulp cold irritation response may occur at 6 months or more.</p>","PeriodicalId":21709,"journal":{"name":"上海口腔医学","volume":"35 1","pages":"107-112"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147609647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Short-term effect of Nd:YAG and Er:YAG lasers in the treatment of peri-implantitis in patients with type 2 diabetes].","authors":"Bin Sun, Ping Wang","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the short-term efficacy of Nd:YAG laser and Er:YAG laser in the treatment of peri-implantitis in patients with type 2 diabetes.</p><p><strong>Methods: </strong>A total of 97 patients with peri-implantitis of type 2 diabetes mellitus who were admitted from February 2021 to February 2024 were selected and divided into group A (n=48, Nd:YAG laser) and group B (n=49, Er:YAG laser) by random number table method.The periodontal indicators, levels of inflammatory factors, degree of bone resorption, bacterial content in gingival crevicular fluid, blood glucose levels, quality of life scores and therapeutic effects of the two groups of patients before and after treatment were compared.</p><p><strong>Results: </strong>After treatment, the sulcus bleeding index (SBI), plaque index (PLI) and probing depth (PD) in group A and B decreased significantly. SBI, PLI and PD in group A were significantly lower than those in group B(P＜0.05). After treatment, the bone resorption at the proximal and distal margins in groups A and B decreased significantly. The bone resorption at the proximal and distal margins in group A was significantly lower than that in group B(P＜0.05). The levels of inflammatory factors in the two groups decreased significantly after treatment. IL-6, tumor necrosis factor α(TNF-α) and matrix metalloproteinase-8 (MMP-8) of group A were significantly lower than those of group B (P＜0.05). The bacterial content of gingival crevicular fluid in both groups decreased significantly after treatment. Group A was significantly lower than that in group B (P＜0.05). There was no significant difference in blood glucose levels between the two groups of patients before and after treatment(P＞0.05). After treatment, the quality of life scores of both groups increased significantly. The physical function, psychological function and total score of group A were significantly higher than those of group B(P＜0.05). There was no significant difference in the total effective rate of treatment between the two groups(P＞0.05).</p><p><strong>Conclusions: </strong>Nd:YAG laser treatment for peri-implantitis in patients with type 2 diabetes can effectively improve periodontal conditions, reduce bone resorption, lower the levels of inflammatory factors and the bacterial content in gingival crevicular fluid, and enhance the quality of life.</p>","PeriodicalId":21709,"journal":{"name":"上海口腔医学","volume":"35 1","pages":"54-59"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147609720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Evaluation on the effect of grading management of severe early childhood caries in infants in Shanghai Jing 'an District].","authors":"Qiwen Chen, Qin Zhou, Yanhua Shen, Xuedi Yu, Xiaoli Zeng, Jin Yu, Huafeng Jiang, Miao Miao, Le Shi","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Purpose: </strong>Through specialty collaboration model, an evaluation was conducted based on graded management of severe early childhood caries in infants who are aged 12-18 months in Jing'an District, Shanghai.</p><p><strong>Methods: </strong>Using the random cluster sampling method, totally 200 children aged 12 to 18 months were selected from each of the two community health care centers in Shanghai Jing'an District during September 2021 to March 2022, allocated as the control group and the experimental group, and caries risk assessment was conducted. Children in the control group received routine oral health care at the child health department, while children in the experimental group adopted dental caries grading management based on collaboration of specialty. A re-evaluation was conducted after 18 months of intervention.</p><p><strong>Results: </strong>After 18 months of intervention, totally 31 of the 400 infants were lost to follow-up, the total caries prevalence rate was 22.8%. The caries prevalence rate in the control group was 29.8%, while that in the experimental group was 16.0%, with significant difference between the two groups (P=0.002). The reduction rate of caries risk grade in the experimental group was significantly higher than that in the control group(P=0.012). The caries related factors in the control group included eating sugar-containing food or beverage more than 3 times/day (P＜0.001), receiving professional fluoridation within 12 months(P＜0.001) and regular oral examination(P=0.023). The caries related factors in the experimental group included eating sugar-containing food or beverage more than 3 times/day（P=0.005）, the caregiver performing floss for the child every day (P=0.022) and brush for the child every day(P=0.007).</p><p><strong>Conclusions: </strong>It is capable to effectively reduce the caries prevalence rate and the risk of severe early childhood caries in infants aged 12-18 months by adopting dental caries grading management based on collaboration of specialty.</p>","PeriodicalId":21709,"journal":{"name":"上海口腔医学","volume":"35 1","pages":"101-106"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147609727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}