上海口腔医学最新文献

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[Three dimensional finite element analysis of different restoration types and materials for maxillary first premolar with large defect]. 上颌大缺损第一前磨牙不同修复方式及材料的三维有限元分析
上海口腔医学 Pub Date : 2025-06-01
Xiaoman Li, Benjian Tian, Miadili Mirealimu, Yiming Gao
{"title":"[Three dimensional finite element analysis of different restoration types and materials for maxillary first premolar with large defect].","authors":"Xiaoman Li, Benjian Tian, Miadili Mirealimu, Yiming Gao","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Purpose: </strong>To provide references for the selection of restoration types and materials for the first premolar with large defect in clinical practice.</p><p><strong>Methods: </strong>A large area defect model of the maxillary first premolar was established and repaired with different types and materials, including group A (inlay group), group B (endocrown group), group C (fiber post core crown group), and group D (pure titanium post core crown group). And then, according to different repair materials, it was divided into 3 subgroups, namely group 1 (zirconia), group 2 (glass ceramic), and group 3 (resin based ceramic), totaling 12 groups. The stress distribution and magnitude were investigated using finite element analysis software.</p><p><strong>Results: </strong>In the inlay group, the stress concentration area was large and tended to spread along the neck of tooth; in the post core crown group and endocrown group, the stress distribution was more uniform. In terms of restorative materials for endocrown, resin based ceramic materials had the lowest stress, followed by glass ceramic materials, and zirconia materials had the highest stress.</p><p><strong>Conclusions: </strong>Large defects of the first premolar can be repaired with endocrowns and post core crowns, and endocrowns have good applicability and advantages. Resin based ceramic materials are recommended for the selection of the endocrown materials for the least stress of the remaining tooth.</p>","PeriodicalId":21709,"journal":{"name":"上海口腔医学","volume":"34 3","pages":"257-261"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144967678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Evaluation of the effect of concentrated growth factor membrane and Haiao oral repair membrane on the preservation of tooth extraction site in the posterior tooth region]. [浓缩生长因子膜与海奥口腔修复膜对后牙区拔牙部位保存效果的评价]。
上海口腔医学 Pub Date : 2025-06-01
Shaoguang Hu, Cuiling Wu, Quan Wang, Meihong Yin, Houxue Lin
{"title":"[Evaluation of the effect of concentrated growth factor membrane and Haiao oral repair membrane on the preservation of tooth extraction site in the posterior tooth region].","authors":"Shaoguang Hu, Cuiling Wu, Quan Wang, Meihong Yin, Houxue Lin","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the effect of concentrated growth factor (CGF) membrane and Haiao oral repair membrane on the preservation of extraction sites in the posterior area of teeth.</p><p><strong>Methods: </strong>A total of 96 patients requiring site preservation after posterior tooth extraction from January 2020 to December 2022 were selected and divided into groups A and B by random number table method, with 48 cases in each group. After tooth extraction, Bio-Oss bone powder was used to cover tooth extraction wound in group A with CGF membrane, and in group B with Haiao oral repair membrane. The healing of the operative area, the changes of vertical height and horizontal width of alveolar bone, visual analog scoring (VAS) of pain, the changes of buccal and palatal tissue thickness and the rate of bone replantation were compared between the two groups.</p><p><strong>Results: </strong>One week after operation, the tooth extraction wound in group A healed well, while 2 cases in group B healed poorly, but there was no significant difference between the two groups(P>0.05). Before surgery, there was no significant difference in vertical height and horizontal width of alveolar bone between the two groups(P>0.05); at 6 months after operation, the vertical height of alveolar bone was significantly increased and the horizontal width was significantly decreased(P<0.05), but there was no significant difference between the two groups(P>0.05).The VAS score of pain 1 week after surgery in 2 groups was lower than that 3 days and 24 hours after surgery, and the VAS score of pain in group A was lower, and the interaction between groups, and time points were significantly different(P<0.05).There was no significant difference in the thickness of buccal and palatal tissues between the two groups before and 6 months after surgery(P>0.05); at 6 months after surgery, the tissue thickness of the palatal side in group B was significantly lower than before surgery(P<0.05). Six months after surgery, the bone replantation rates in group A and group B were 4.17% and 6.25%, respectively, with no significant difference between the two groups(P>0.05).</p><p><strong>Conclusions: </strong>Both CGF membrane and Haiao oral repair membrane have good efficacy in the preservation of tooth extraction sites in the posterior region, which can effectively delay alveolar bone mass absorption, and CGF has a better effect in reducing short-term postoperative pain in patients.</p>","PeriodicalId":21709,"journal":{"name":"上海口腔医学","volume":"34 3","pages":"276-280"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144967560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Comparative quantitative analysis of palatal masticatory mucosal thickness between Han and Uygur in Xinjiang area]. [新疆地区汉族与维吾尔族腭咀嚼粘膜厚度的比较定量分析]。
上海口腔医学 Pub Date : 2025-06-01
Tulajiang Yipalamu, Ting Ma, Yasen Maimaiti
{"title":"[Comparative quantitative analysis of palatal masticatory mucosal thickness between Han and Uygur in Xinjiang area].","authors":"Tulajiang Yipalamu, Ting Ma, Yasen Maimaiti","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Purpose: </strong>To measure and compare the palatal masticatory mucosal thickness from maxillary canine to the second molar region of Han and Uygur periodontally healthy people in Xinjiang area by using CBCT, and to analyze the related factors.</p><p><strong>Methods: </strong>CBCT images of 48 periodontally healthy subjects in each nationality were selected from the Dental Clinic of the First Affiliated Hospital of Xinjiang Medical University according to the inclusion and exclusion criteria. The thickness of the palatal masticatory mucosa, the height and width of the palatine fornices, and the location of the greater palatine foramen were measured at the distance of 3, 6, 9 and 12 mm from the gingival margin.</p><p><strong>Results: </strong>There were significant differences in the average palatal mucosal thickness at the distance of 3, 6, 9 and 12 mm from the gingival margin, different anatomical shapes of the palatine fornices and different age groups between Han and Uygur(P<0.05). There was no significant difference in the distribution of the greater palatine foramen between Han and Uygur(P>0.05). However, the correlation between mucosal thickness and related factors in Han population was closer. The general trend was similar between the two groups: ①from 3mm to 12mm from the gingival margin, the mucosal thickness first increased and then decreased from the canine to the second premolar, decreased first and then increased from the first molar, and continued to increase from the second molar; ②the mucosal thickness of canine, first premolar and first molar was affected by age and the anatomical morphology of palatine fornix. The mucosal thickness of second premolar was affected by age, and the mucosal thickness of second molar was affected by the anatomical morphology of palatine fornix; ③the greater palatal foramen was mostly located in the distal region of the second molar, and the distance from the greater palatal foramen to the midpalatal suture was smaller in the HFT group than in the LFT group(P<0.05).</p><p><strong>Conclusions: </strong>The most suitable donor site for autologous connective tissue transplantation in both nationalities is the palatal masticatory mucosa when the distance between the gingival margin of the maxillary first and second premolars is 3-9 mm.</p>","PeriodicalId":21709,"journal":{"name":"上海口腔医学","volume":"34 3","pages":"318-325"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144967562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Application of 3D oral scanning combined with digital guide plate in implant restoration of mandibular posterior dentition defect]. [三维口腔扫描联合数字引导板在下颌后牙列缺损种植体修复中的应用]。
上海口腔医学 Pub Date : 2025-06-01
Shuhua Ye, Jiadong Zhu, Ningning Deng
{"title":"[Application of 3D oral scanning combined with digital guide plate in implant restoration of mandibular posterior dentition defect].","authors":"Shuhua Ye, Jiadong Zhu, Ningning Deng","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate the value of 3D oral scanning combined with digital guide plate in implant restoration of mandibular posterior dentition defect.</p><p><strong>Methods: </strong>A total of 96 patients with mandibular posterior dentition defects treated in Hangzhou Stomatology Hospital from March 2021 to October 2022 were randomly divided into control group (48 cases) and experimental group (48 cases). The control group was treated with conventional implant repair, while the experimental group was treated with 3D oral scanning combined with digital guide plate implant repair. The operation related indexes, implant accuracy, implant stability, alveolar ridge and parietal bone absorption of the two groups were compared, and the implant success rates, complication rates and patient satisfaction were also evaluated.</p><p><strong>Results: </strong>There was no significant difference in postoperative pain time and swelling time between the two groups(P>0.05), but the surgical time in the experimental group was significantly shorter than that in the control group(P<0.05). The crown deviation, root deviation, depth deviation and angle deviation in the experimental group were significantly smaller than those in the control group(P<0.05). The success rate of the experimental group was significantly higher than that of the control group(P<0.05). There was no statistically significant difference in the planting success rate and stability coefficient between the two groups(P>0.05), and the absorption of alveolar crest bone in the experimental group was significantly lower than that in the control group(P<0.05). The total incidence of complications in the experimental group was significantly lower than that in the control group (P<0.05). The satisfaction of patients in the experimental group was significantly higher than that in the control group(P<0.05).</p><p><strong>Conclusions: </strong>The application of 3D oral scanning combined with digital guide plate in implant restoration of mandibular posterior dentition defect can effectively shorten the operation time, improve the accuracy of implant, reduce the complications, and improve patients' satisfaction.</p>","PeriodicalId":21709,"journal":{"name":"上海口腔医学","volume":"34 3","pages":"286-290"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144967523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Application of the jigsaw classroom method in oral histology and pathology course]. 【拼图课堂教学法在口腔组织病理学教学中的应用】。
上海口腔医学 Pub Date : 2025-06-01
Yanjin Wang, Zhiming Qin, Tiejun Li, Tingjiao Liu
{"title":"[Application of the jigsaw classroom method in oral histology and pathology course].","authors":"Yanjin Wang, Zhiming Qin, Tiejun Li, Tingjiao Liu","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Purpose: </strong>This study applied jigsaw classroom method to reform some contents of oral histology and pathology course, aiming at exploring new methods of undergraduate education in stomatology, achieving more dimensional learning goals and improving learning effects.</p><p><strong>Methods: </strong>Twenty-four undergraduates from the School of Stomatology of Fudan University were selected as the study objects. Under the guidance of teachers, students studied oral squamous cell carcinoma cases online and offline for 3 weeks. The teaching effect was evaluated from the perspectives of teachers and students through subjective and objective examination, questionnaire survey and interview.</p><p><strong>Results: </strong>The objective questions were tested before and 4 months after the final report, with an average of 7.17 and 7.41(out of 10 points). There was no significant difference between the two scores, indicating that the students achieved their knowledge goals and had a good long-term learning effect. The average scores of case report and report were over 90(out of 100 points). 75% of the students were satisfied with the learning effect, 37.5% preferred this method, and over 80% of the students thought that this method had exercised many abilities, improved their understanding of the importance and significance of oral pathology, and achieved the goals of ability and literacy.</p><p><strong>Conclusions: </strong>Compared with traditional teaching, jigsaw classroom can make students master knowledge more firmly, exercise their ability and accomplishment, and achieve better learning effect. The specific implementation can be adjusted according to the situation, and it needs further investigation.</p>","PeriodicalId":21709,"journal":{"name":"上海口腔医学","volume":"34 3","pages":"332-336"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144967449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[A retrospective study on clinical outcomes of implant-supported rehabilitations in patients with alveolar cleft]. [牙槽裂患者种植体支持康复的临床结果回顾性研究]。
上海口腔医学 Pub Date : 2025-06-01
Rong Lan, Yiqun Wu, Wei Huang, Zhenqi Chen, Xiaogang Pan, Feng Wang
{"title":"[A retrospective study on clinical outcomes of implant-supported rehabilitations in patients with alveolar cleft].","authors":"Rong Lan, Yiqun Wu, Wei Huang, Zhenqi Chen, Xiaogang Pan, Feng Wang","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Purpose: </strong>To retrospectively evaluate the clinical outcomes of implant-supported prosthesis in alveolar cleft patients.</p><p><strong>Methods: </strong>A total of 14 patients with alveolar cleft underwent implant restoration in Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine from January 2015 to January 2023 were collected. Among them, 9 were male and 5 were female. The age ranged from 18 to 52 years, with a mean of (26.1±10.6) years. The sequence treatment history of patients with cleft lip and palate and the effect of implant repair were retrospectively analyzed.</p><p><strong>Results: </strong>Bone grafting in the fissured area failed repeatedly in 1 patient and no implant was implanted. A total of 21 implants were implanted in the remaining 13 patients with alveolar cleft, all of which achieved good osseointegration. In 10 cases, one implant was implanted in each fissure area for single crown or single end bridge repair. In 3 cases, 11 implants were implanted in the non-fissure area for fixed bridge repair. Seven patients with single implant were followed up for 6 to 96 months, with an average of (39.4±29.2) months. During their visits, patients underwent various examinations, including pink aesthetic score (PES) averaging 10.16±0.98, white aesthetic score(WES) averaging 8.50±1.23, and probing depth(PD) with a mean of (2.68±0.61) mm. Additionally, gingival index(GI) was recorded with a mean of 1.33±1.10, and marginal bone loss(MBL) was measured with a mean of (0.17±0.35) mm. The width of the mid-labial keratinized mucosa was observed to be (5.14±2.10) mm.</p><p><strong>Conclusions: </strong>Implant-supported prosthesis in the alveolar cleft area after well-established multidisciplinary sequential treatments have predictable middle-term success rate, satisfactory aesthetic outcomes and stable peri-implant soft and hard tissue conditions.</p>","PeriodicalId":21709,"journal":{"name":"上海口腔医学","volume":"34 3","pages":"326-331"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144967463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Prediction value of miR-146a-5p, PI3K and Akt in gingival crevicular fluid on the severity of chronic periodontitis]. [龈沟液中miR-146a-5p、PI3K、Akt对慢性牙周炎严重程度的预测价值]。
上海口腔医学 Pub Date : 2025-06-01
Jiaming Gao, Naixin Zhang, Jiasheng Yue
{"title":"[Prediction value of miR-146a-5p, PI3K and Akt in gingival crevicular fluid on the severity of chronic periodontitis].","authors":"Jiaming Gao, Naixin Zhang, Jiasheng Yue","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate the predictive value of microRNA-146a-5p (miR-146a-5p), phosphatidylinositol 3 kinase (PI3K) and protein kinase B (Akt) in gingival crevicular fluid for the severity of chronic periodontitis (CP).</p><p><strong>Methods: </strong>A total of 121 CP patients admitted to Qinhuangdao Hospital of Peking University Third Hospital from March 2021 to March 2024 were selected. According to the severity of the disease, the patients were divided into mild-to-moderate group(n=85) and severe group(n=36). The levels of miR-146a-5p, PI3K and Akt in gingival crevicular fluid were detected, and probing depth(PD), clinical attachment loss(CAL), sulcus bleeding index(SBI) were collected to analyze the factors affecting the severity of CP. Area under the curve (AUC) of receiver operating characteristic (ROC) was used to analyze the predictive value of miR-146a-5p, PI3K and Akt in CP severity.</p><p><strong>Results: </strong>The miR-146a-5p, PI3K, Akt, probing depth(PD), the level of clinical attachment loss (CAL), the ratio of combined diabetes and the smoking history in the severe group were significantly higher than those in the mild-moderate group(P<0.05). Logistic regression analysis showed that diabetes mellitus(OR=3.252, 95%CI: 1.312-8.059), miR-146a-5p level(OR=5.273, 95%CI: 2.469-11.258), PI3K level (OR=4.877, 95%CI: 1.812-13.123) and Akt level (OR=4.421, 95%CI: 1.669-11.710) were independent risk factors affecting the severity of the disease(P<0.05). ROC results showed that the AUC of miR-146a-5p, PI3K, Akt and their combined prediction of CP severity were 0.801, 0.789, 0.772 and 0.898, respectively(P<0.05).</p><p><strong>Conclusions: </strong>The levels of miR-146a-5p, PI3K and Akt in gingival crevicular fluid are independent risk factors for CP severity, and combined detection of the three parameters can better predict the severity of patients' disease.</p>","PeriodicalId":21709,"journal":{"name":"上海口腔医学","volume":"34 3","pages":"281-285"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144967654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Three-dimensional finite element analysis of stress distribution and influence of stainless steel preformed crown on temporomandibular joint in children]. [不锈钢预冠对儿童颞下颌关节应力分布及影响的三维有限元分析]。
上海口腔医学 Pub Date : 2025-06-01
Yulu Zhang, Jia Liu
{"title":"[Three-dimensional finite element analysis of stress distribution and influence of stainless steel preformed crown on temporomandibular joint in children].","authors":"Yulu Zhang, Jia Liu","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Purpose: </strong>To study the stress effect and distribution pattern of the first and second primary molars on temporomandibular joint in the restoration of upper and lower teeth with stainless steel precrown using three-dimensional finite element method, in order to provide theoretical basis for clinical diagnosis and treatment.</p><p><strong>Methods: </strong>CBCT data from one male and one female aged 3, 6, and 8 years old were collected, and the first and second maxillary molar teeth, upper and lower mandible, dentition and temporomandibular joint(TMJ) data were obtained respectively. Three-dimensional finite element method was used to create the finite element models of the first and second maxillary molar teeth, upper and lower mandible, dentition and TMJ, respectively. The stress distribution of the TMJ with the stainless steel prefabricated crown raised at different heights was analyzed by applying the load force.</p><p><strong>Result: </strong>After stainless steel crown repair, different loads were applied to the TMJ, and the maximum stress values generated by the condyle were analyzed and compared. The stress difference analysis results of the condyle in children aged 3, 6, and 8 under different genders, ages, and load angles were statistically significant(P<0.01), while the stress difference analysis results of different groups were not statistically significant(P>0.05).</p><p><strong>Conclusions: </strong>After restoring primary molars with stainless steel preformed crowns, applying three angle loads results in a more uniform distribution of stress in the TMJ at normal occlusal height. Therefore, using stainless steel crowns to restore normal occlusal height in clinical restorative treatment is beneficial for reducing stress concentration in TMJ and improving the efficacy and long-term prognosis of primary molars restoration.</p>","PeriodicalId":21709,"journal":{"name":"上海口腔医学","volume":"34 3","pages":"237-243"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144967681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Study on the therapeutic effect and potential mechanisms of astaxanthin electrospun patches on oral mucosal ulcers in rats]. 虾青素静电纺丝贴片对大鼠口腔黏膜溃疡的治疗作用及可能机制的研究
上海口腔医学 Pub Date : 2025-06-01
Huan Wang, Pei Sun, Zhaochen Liu, Hui Zhang, Yiqing Guo, Houping Zhao, Peiyan Wang, Jing Deng
{"title":"[Study on the therapeutic effect and potential mechanisms of astaxanthin electrospun patches on oral mucosal ulcers in rats].","authors":"Huan Wang, Pei Sun, Zhaochen Liu, Hui Zhang, Yiqing Guo, Houping Zhao, Peiyan Wang, Jing Deng","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate the effect and underlying mechanism of astaxanthin electrospun patches in treating oral ulcers in rats.</p><p><strong>Methods: </strong>An oral ulcer model of rats was established by mechanical trauma, then the rats were randomly divided into astaxanthin electrospun patch group, chitosan patch group, metronidazole patch group and blank control group. The ulcer healing time and the area healing rate of each group were observed. The pathological changes of ulcer tissues in each group were observed and scored by H-E staining 2, 4 and 6 days after drug administration. Meanwhile, the toxic effects of the drugs on the rat organs were detected. The changes in the levels of superoxide dismutase (SOD) and malondialdehyde (MDA) in ulcer tissues were detected by WST-1 and TBA methods. Tumor necrosis factor-α (TNF-α) and Interleukin 6 (IL-6) were analyzed through immunohistochemistry experiments.</p><p><strong>Results: </strong>Compared with the other groups, the astaxanthin electrospun patch could significantly accelerate the reduction of the ulcer area, promote its pathological healing, reduce the expression levels of TNF-α and IL-6, and significantly decrease the content of MDA in the ulcer tissue while increasing the activity of SOD. Six days after administration, there were significant differences in the levels of SOD and MDA compared with the blank control group and the metronidazole patch group(P<0.05), while there was no significant difference compared with the chitosan patch group(P>0.05).</p><p><strong>Conclusions: </strong>The astaxanthin electrospun patches have better performance in promoting ulcer healing, which may be related to their strong antioxidant and anti-inflammatory properties. It is expected to provide a natural marine preparation with better efficacy for the treatment of oral ulcers.</p>","PeriodicalId":21709,"journal":{"name":"上海口腔医学","volume":"34 3","pages":"225-232"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144967698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[The impact of oral occlusal exercises on occlusal performance of oral cancer patients following segmental mandibulectomy without simultaneous reconstruction]. [口腔咬合练习对口腔癌患者下颌骨节段性切除术后咬合功能的影响]。
上海口腔医学 Pub Date : 2025-04-01
Ling Yang, Tian Zhou, Ning Zhao, Xingzhou Qu, Weihong Chen, Yan Zhao, Lili Hou
{"title":"[The impact of oral occlusal exercises on occlusal performance of oral cancer patients following segmental mandibulectomy without simultaneous reconstruction].","authors":"Ling Yang, Tian Zhou, Ning Zhao, Xingzhou Qu, Weihong Chen, Yan Zhao, Lili Hou","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate the effects of oral occlusion exercises on occlusal performance of oral cancer patients who underwent segmental mandibular resection without simultaneous reconstruction.</p><p><strong>Methods: </strong>From October 2022 to May 2023, a total of 63 oral cancer patients who underwent segmental mandibular resection without reconstruction at the Department of Oromaxillofacial Head and Neck Oncology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine were selected. They were randomly divided into control group (30 patients) and experimental group (33 patients). The control group received conventional care, while the experimental group underwent oral occlusion exercises except conventional care. After three months, the maximum total occlusal force(TOF), asymmetry index of occlusal force(AOF), center of occlusal force(COF), and mastication efficiency of both groups were compared. Statistical analysis was conducted using SPSS 26.0 software package.</p><p><strong>Results: </strong>Compared with the control group, TOF in the experimental group was increased, AOF and COF were decreased, and the differences were statistically significant(P<0.01). The masticatory efficiency of the experimental group was significantly better than that of the control group(P<0.01).</p><p><strong>Conclusions: </strong>Oral occlusal exercises can improve occlusal performance in patients with mandibular resection without reconstruction, but larger sample size and rigorous design are needed to further verify its clinical effect and mechanism.</p>","PeriodicalId":21709,"journal":{"name":"上海口腔医学","volume":"34 2","pages":"184-190"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144476611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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