Scientific and Technical Bulletin оf State Scientific Research Control Institute of Veterinary Medical Products and Fodder Additives аnd Institute of Animal Biology最新文献

{"title":"EFFECTIVENESS OF IVERMECTIN AGAINST ECTO- AND ENDO-PARASITIC INVASION OF DOGS","authors":"O. L. Tishyn, I. D. Yuskiv, L. L. Yuskiv","doi":"10.36359/scivp.2024-25-1.27","DOIUrl":"https://doi.org/10.36359/scivp.2024-25-1.27","url":null,"abstract":"For ecto- and endoparasitic infestations of animals, preparations based on ivermectin are used. That is why the purpose of the work was to conduct a field study to evaluate the effectiveness of the researched drug \"Profiverm 1%\" (solution for injections) in comparison with the drug \"Brovermectin\" (solution for injections) against ecto- and endoparasitic infestations of dogs of various breeds, age and gender. \u0000According to the results of the acarological examination of the dogs of the experimental and control groups, it was established that they were parasitized by the ear mite Otodectos cynotis with an intensity of 9 to 24 specimens on the surface of the animal's auricle, with an average intensity of infestation of 16.4 ± 1.24 mites per animal. Clinical signs of infection were manifested by itching, the presence of atypical contents in the ears, otodectous foci in the form of scabs and crusts. \u0000After subcutaneous injection of the studied drug \"Profiverm 1 %\" for 7 days, its effectiveness for otodectosis in dogs was 69.7 %, and after the use of the comparison drug \"Brovermectin\" – 67.6 %. On the 14th day after treatment of dogs with the studied drug \"Profiverm 1%\", its effectiveness was 95.0 %, and the effectiveness of the comparative drug \"Brovermectin\" was 93.7 %. On the 21st day of the experiment, both drugs showed 100 % effectiveness in otodectic infestation of dogs. \u0000According to the results of helminthological studies, the animals of the experimental and control groups were found to be spontaneously infected with endoparasites, the causative agents of nematodes: Toxocara canis with an intensity of invasion (II) from 98 to 156 eggs in one gram of faeces (ЕGF), Toxascaris leonina – from 68 to 118 ЕGF and Ancylostoma caninum – from 36 to 78 ЕGF. Clinically, nematodes in dogs were manifested by a depressed state, deterioration of appetite, mild diarrhea and vomiting were observed in some animals, paleness of the mucous membranes was noted. \u0000The obtained results show that for spontaneous toxocariasis infestation in dogs on the 7th day after deworming, the effectiveness of the studied drug \"Profiverm 1%\" was 92.5 %, and the comparison drug \"Brovermectin\" was 90.0 %. On the 14th day after deworming the animals, the effectiveness of both drugs was 100 %. \u0000In case of spontaneous toxascarosis infestation of dogs, it was established that on the 7th day after deworming, the effectiveness of the studied drug was 94.1 %, and the effectiveness of the comparison drug was 92.4 %. On the 14th day after deworming the animals, the effectiveness of both drugs was 100 %. \u0000Helminthological studies established that the effectiveness of veterinary drugs was 100% for spontaneous аncylostomosеs infestation in dogs 7 and 14 days after the use of the researched drug and the comparator drug in the recommended doses. \u0000Field tests showed that the veterinary drug \"Profiverm 1 %\" and \"Brovermectin\" with single subcutaneous use in the recommended doses of the manufacturer wer","PeriodicalId":21617,"journal":{"name":"Scientific and Technical Bulletin оf State Scientific Research Control Institute of Veterinary Medical Products and Fodder Additives аnd Institute of Animal Biology","volume":"31 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140967583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"INVESTIGATION OF THE EFFICIENCY OF NON-STEROIDAL ANTI-INFLAMMATORY VETERINARY MEDICINAL PRODUCT IN THE COMPLEX TREATMENT OF DISEASES OF THE MUSCULOSKELETAL SYSTEM OF PIGS","authors":"N. Lisova, O. Pyatnychko, M. Zhyla, N. Shkodyak, O. Sobodosh, O. Maksymovych","doi":"10.36359/scivp.2024-25-1.11","DOIUrl":"https://doi.org/10.36359/scivp.2024-25-1.11","url":null,"abstract":"The article presents the results of clinical trials of a non-steroidal anti-inflammatory veterinary drug when administered to fattening piglets with clinical signs of musculoskeletal diseases. For the treatment of the diseases, piglets of the experimental (I) and control (II) groups received an antimicrobial drug based on the tetracycline antibiotic. The animals of the experimental group were additionally administered orally with drinking water the test non-steroidal anti-inflammatory drug based on acetylsalicylic, ascorbic and citric acids, in the recommended dosage by the manufacturer. Blood for laboratory tests was selected from piglets before and after the use of drugs. Studies of hematological and biochemical parameters were conducted according to generally accepted methods. The therapeutic efficiecy of the drug and its effect on the morphofunctional state of the body was evaluated by comparing the statistically processed data obtained before and after treatment, as well as in comparison with the indicators of animals of the control group. The analysis of hematological parameters of piglets during the experiment showed a decrease in the number of leukocytes in the animal’s blood after the use of drugs. The normalization of the leukogram was also noted by reducing the relative number of rod-nuclear neutrophils. In particular, this indicator decreased by 17.4% in group I piglets, and by 12% in group II piglets. It is noted that the clinical response to therapy was faster and more pronounced in animals, which used a non-steroidal anti-inflammatory drug in combination with an antimicrobial drug than in piglets, which were treated only by antibiotic. According to the results of biochemical studies, it was found that the content of urea in the serum of animals of both groups before the use of drugs exceeded more than 3 times the upper limit of physiological values for a given age group of piglets. After therapy with the drugs a significant decrease in the urea content in the blood serum of groups 1 and 2 animals was noted by 3.42 and 2.98 times, respectively. It is established that the activity of marker enzymes of the liver physiological state (ALT, AST) in the serum of group I piglets after complex treatment with the studied drugs was slightly reduced and was within the physiological values. In the serum of group II animals, which were treated only with antimicrobial drug, ALT activity increased by 12,0 %, and AST – by 38,6 %, compared to the initial data, and exceeded the limit of physiological values. An increase in the content of iron by 37.4 % in the blood of group I piglets, compared to the period before drug administration, was noted. No adverse reactions and negative phenomena were detected during the use of the test drug, and the drug was well tolerated. According to the clinical condition of the experimental group animals and the results of laboratory tests it was established that the use of non-steroidal anti-inflammatory drugs based o","PeriodicalId":21617,"journal":{"name":"Scientific and Technical Bulletin оf State Scientific Research Control Institute of Veterinary Medical Products and Fodder Additives аnd Institute of Animal Biology","volume":"7 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140968839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ETIOTROPIC THERAPY OF BACTERIAL RESPIRATORY AND INTESTINAL INFECTIONS OF CATTLE","authors":"T. Stetsko","doi":"10.36359/scivp.2024-25-1.23","DOIUrl":"https://doi.org/10.36359/scivp.2024-25-1.23","url":null,"abstract":"Bacterial infections take one of the main places in the pathology of cattle. The article presents a literature review on the etiotropic therapy of bacterial respiratory and intestinal diseases of cattle. Means of etiotropic therapy of bacterial infections are chemotherapeutic drugs, the active substances of which are antibiotics and sulfonamides, to which the causative agents of these diseases are sensitive. \u0000Respiratory infections are the most common diseases of young cattle. The causative agents of bacterial pneumonia include Mannheimia hemolytica, Pasteurella multocida, Mycoplasma spp., Histophilus somni, Arcanobacterium pyogenes, Streptococcus pneumoniae and others. For the treatment of pneumonia in young cattle, benzylpenicillin, aminopenicillins (amoxicillin, ampicillin), tetracyclines (oxytetracycline, doxycycline), spectinomycin, combination of sulfonamide and trimethoprim, tiamulin, macrolides (tylosin, spiramycin, tilmicosin, tulathromycin, gamithromycin), fluorphenicol, cephalosporins of the third or fourth generations (ceftiofur, cefquinome), fluoroquinolones (enrofloxacin, danofloxacin, marbofloxacin) are mainly used. \u0000One of the most common diseases of calves from birth to 3 months of age is gastroenteritis with a complex of diarrheal symptoms. Bacterial agents that cause diarrhea include pathogenic escherichia, salmonella, clostridia, citrobacteria, enterococci, yersinia, pseudomonads, campylobacter, and others. Opportunistic microorganisms, what include bacteria of the Enterobacteriaceae family, are played a special role in the occurrence of diseases of the digestive tract of young cattle. \u0000Etiotropic therapy of bacterial intestinal infections of calves with diarrhea syndrome is aimed at the causative agent of intestinal infection in the blood due to bacteremia and in the small intestine due to bacterial growth. Antimicrobial drugs of the first choice for the treatment of diarrheal enteritis of calves are parenteral amoxicillin and ampicillin, amoxicillin with clavulanic acid, a combination of sulfonamide/trimethoprim, and the second choice are cephalosporins of the third (ceftiofur) and fourth (cefquinome) generations. Aminoglycosides (neomycin, gentamicin, apramycin, spectinomycin) and fluoroquinolones are the last choice for the treatment of bacterial intestinal infections of calves. For the treatment of colibacteriosis and salmonellosis of calves, colistin, an antibiotic of the polymyxin group, what is a critically important antimicrobial drug for both veterinary and human medicine, is often used. \u0000It is important that the choice of means of etiotropic therapy of bacterial respiratory and intestinal infections of cattle is based on the antimicrobial sensitivity of the pathogen (pathogens) of the disease, what will increase the effectiveness of treatment and minimize the selection of antibiotic-resistant strains of microorganisms.","PeriodicalId":21617,"journal":{"name":"Scientific and Technical Bulletin оf State Scientific Research Control Institute of Veterinary Medical Products and Fodder Additives аnd Institute of Animal Biology","volume":"55 50","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140970022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PECULIARITIES OF THE INFLUENCE OF TYLOZIN ON THE METABOLISM OF PROTEINS AND AMINO ACIDS IN CHICKEN","authors":"N. V. Slyusar","doi":"10.36359/scivp.2024-25-1.21","DOIUrl":"https://doi.org/10.36359/scivp.2024-25-1.21","url":null,"abstract":"Over the last decade, poultry farming, both for meat and eggs, has been widely developed in our country. Poultry products are widely used in the diets of the population. In this problem, it is necessary to observe the careful application of antimicrobial drugs to productive animals, as they are used by humans and not to disturb the ecosystem and not cause the formation of resistant microflora. \u0000Taking into consideration that veterinary medicine should be more preventive than curative, the problems of poultry treatment are poorly described, it was decided that it is necessary to work with healthy organisms. Because the physiological reactivity of the body changes with pathologies even without medical interventions. \u0000Methods of using macrolides and other pharmacological agents in sick animals and poultry are described in the literature, but there are not enough works that would highlight the data on the effect of this agent on protein and amino acid metabolism in healthy chickens. \u0000In addition, it is known that metabolic processes in poultry take place with a fairly high intensity, and this is definitely reflected in the amount of doses of various drugs, and antibiotics in particular. Medicines in the bird's body, accordingly, are biotransformed more quickly and removed from the body faster with droppings and eggs, others accumulate in various organs and muscles. Therefore, it is important to know how the biosynthesis of the main proteins and the level of free amino acids changes under the action of the antimicrobial agent Tylozin on the days of administration and in the period after the administration of the antibiotic. The results of the research are informative. \u0000The work is devoted to the study of the influence of an antimicrobial drug from the pharmacological group of macrolides on the metabolism of amino acids and proteins in chickens in a comparative aspect. At the same time, egg production in laying hens aged 140-150 days was taken into account. The influence of different doses of Tylosin on the protein and amino acid composition of chickens during the period of use and after the end of drug administration was studied. \u0000It was established that changes in the metabolism of total protein, its fractions and amino acid nitrogen in the blood serum occur naturally, long-term, in different directions and, proportionally, depend on the dose of the drug. The effect of the drug was studied in minimum, average and maximum doses.","PeriodicalId":21617,"journal":{"name":"Scientific and Technical Bulletin оf State Scientific Research Control Institute of Veterinary Medical Products and Fodder Additives аnd Institute of Animal Biology","volume":"6 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140967551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MICROSCOPIC CHANGES IN MUSCLES OF RABBITS WITH EXPERIMENTALLY DAMAGED MUSCLE TISSUE UNDER THE INFLUENCE OF TRANSPLANTED MESENCHYMAL STEM CELLS","authors":"N. Stadnyk, A. Mazurkevich","doi":"10.36359/scivp.2024-25-1.22","DOIUrl":"https://doi.org/10.36359/scivp.2024-25-1.22","url":null,"abstract":"Due to the high level of activity of some animals, particularly sports and working animals, muscle injuries are becoming a serious and urgent problem for veterinarians. Sporting events, training and work duties can lead to tears, strains and other injuries to skeletal muscle tissue. Muscle injuries in sports and working animals are a complex problem that requires a careful and comprehensive approach to treatment. These injuries can lead to pain, restricted movement and loss of performance. Traditional treatments, while effective, are often lengthy and not always successful. Therefore, scientists and veterinarians are constantly looking for new and more effective ways to treat and rehabilitate animals to help them recover from injuries faster and more fully. \u0000The main purpose of this article is to review, summarise and analyse histological studies investigating the use of allogeneic mesenchymal stem cells in veterinary medicine for regenerative therapy. An additional goal of the article is to review the results of these studies and highlight the main conclusions regarding the potential use of MSCs in veterinary practice. \u0000The main role in cell therapy is played by allogeneic mesenchymal stem cells (MSCs). These cells, which do not have a specific differentiation, can independently renew themselves and develop into cells with specific functions, making them effective for tissue repair. It is especially important to note that mesenchymal stem cells are promising for veterinary medicine because they are easy to isolate and cultivate. \u0000The article discusses the use of allogeneic mesenchymal stem cells for tissue repair in veterinary medicine in experimental animals, taking into account the results of scientific research conducted by the authors of the article. \u0000The use of a new and promising method of treating animals with damaged muscle tissue based on cellular regeneration can significantly accelerate the recovery of animals after injury and avoid side effects that often occur with traditional treatments.","PeriodicalId":21617,"journal":{"name":"Scientific and Technical Bulletin оf State Scientific Research Control Institute of Veterinary Medical Products and Fodder Additives аnd Institute of Animal Biology","volume":"16 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140967836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SAFETY OF TETRACYCLINES FOR PUBLIC HEALTH AND THE ENVIRONMENT","authors":"Y. Kosenko, N. Ostapiv, L. Zaruma","doi":"10.36359/scivp.2024-25-1.08","DOIUrl":"https://doi.org/10.36359/scivp.2024-25-1.08","url":null,"abstract":"Antimicrobial veterinary medicinal products of the tetracycline class have been most widely used for many years in the veterinary practice, both in Ukraine and in European countries, the USA, Canada, etc. Teteracyclynes have a wide-spectrum activity against gram-positive and gram-negative microorganisms, rickettsia, mycoplasma, chlamydia and protozoan parasites and are successfully used for the treatment of infectious diseases of the gastrointestinal tract, respiratory organs, skin and urogenital infections. Antimicrobial veterinary medicinal products of this class belong to AMEG category D, which is the safest in terms of impact on public health. Tetracyclines are low cost agents, are not high toxic when used in animals, which justifies their frequent choice for empirical treatment. During the monitoring of sales volumes for 2016-2021, antimicrobial veterinary medicinal products of the tetracycline class occupied the largest share among all antimicrobials entering the market in Ukraine (25.9-39.4)%. Most frequently, these veterinary medicinal products are intended for oral administration, but since their low bioavailability (5-15)%, they are excreted from the body almost unchanged. However, there is a danger of the development of tetracyclines resistance and a hazard to the environment and public health, which is explained by the frequent use of this class substances, the permission of large amounts into the soil with manure and water following drinkers washing after the treatment. Tetracyclines are poorly metabolized, and their long-term use in veterinary practice contributes to the bioaccumulation of significant amounts in soil and water. \u0000The main goal of this study were the analysis of veterinary medicinal products containing tetracyclines which were authorized in Ukraine by the category of active substances and route of administration. Another problem of this article was to substantiate the impact of tetracycline class antibiotics on the environment and the acquired antimicrobial resistance in the view of the necessity of their reasonable and safety use for the animals treatment, taking into account the requirements of the current legislation in Ukraine and EU member states. The results of the study proved that antimicrobial veterinary medicinal products containing chlortetracycline, mainly for oral administration, prevail in Ukraine. The bias of this monitoring is the lack information on the volumes of their use in farms and for individual animal species. Although the tetracycline class antibiotics do not belong to persistent bio accumulative toxic substances (PBT), their long-term and widespread use causes concern in view of the possible acquiring antimicrobial resistance and harmful effects on the environment, which will have an impact on public health. It is necessary to introduce regulatory measures to limitation and optimal use of these compounds in veterinary medicine. It is also necessary to deliver information among stakeholders ab","PeriodicalId":21617,"journal":{"name":"Scientific and Technical Bulletin оf State Scientific Research Control Institute of Veterinary Medical Products and Fodder Additives аnd Institute of Animal Biology","volume":"32 16","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140966296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"IMPROVED SELECTION AND BREEDING PARAMETERS OF THE OBROSHYN GRAY BREED GROUP OF GEESE","authors":"M. Petriv, L. V. Ferenc, S. O. Vovk, V. S. Fedorovych","doi":"10.36359/scivp.2024-25-1.16","DOIUrl":"https://doi.org/10.36359/scivp.2024-25-1.16","url":null,"abstract":"The results of the improvement of the selection and genetic parameters of the goose population obtained by purebred linear breeding and geese with blood transfusion of the large gray breed (IV generation) of Obroshyn breeding are given. \u0000The research was conducted on geese of the Obroshyn gray breed group with the aim of increasing the selection and breeding nucleus of geese with high-performance indicators. As a result of the selection and breeding work carried out in 2022, the effectiveness of the introductory crossbreeding of Obroshyn gray geese with great gray geese was proven. Improvement of productive qualities of Obroshyn gray geese was achieved with the infusion of large gray breed blood (IV generation) and preservation of the main qualities of this breed group: good adaptability to local conditions of feeding and maintenance, exterior, quality of meat and feather and down raw materials. \u0000Productivity indicators of Obroshyn gray geese (I group) were: laying capacity – 38,4 pcs.; egg weight – 164,0 g; fertilization of eggs – 86,3 %; hatching of goslings – 76,4 %; live weight of geese at the age of 9 weeks - males 4310 g, females - 3800 g; preservation – 95,0 %. Obroshyn gray geese of the 4th generation obtained by transfusion of large gray breed blood (group II) were characterized by correspondingly higher indicators: in terms of laying by 3,1 %, however, fertilization was lower by 5,8 % and hatching was lower by 4.4%. The preservation of geese in this group was higher by 3,2 %, and the live weight at the age of 9 weeks was 4.4% higher in males and 3.2% higher in females. The geese of the II experimental group were superior to their peers from the I group in terms of meat quality, in terms of the weight of the uncut and cut carcass, and the yield of edible parts. Geese of experimental group II were also characterized by better meat productivity at the age of 9 weeks, in which the mass of pectoral muscles was 7.0% higher in males and 1,4 % higher in females, and the mass of thigh muscles was higher in males and females - by 4,0 and 4,8 %, respectively, than in geese of the I group. \u0000Geese of experimental group II were also characterized by better meat productivity at the age of 9 weeks, in which the mass of pectoral muscles was 7.0% higher in males and 1.4% higher in females, and the mass of thigh muscles was higher in males and females - by 4.0 and 4.8%, respectively, than in geese of the I group.","PeriodicalId":21617,"journal":{"name":"Scientific and Technical Bulletin оf State Scientific Research Control Institute of Veterinary Medical Products and Fodder Additives аnd Institute of Animal Biology","volume":"17 14","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140966754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"DETERMINATION OF PRODUCTIVITY OF COWS IN KETOSIS USING PROBIOTICS","authors":"O. I. Shkromada, Y. K. Vlasenko","doi":"10.36359/scivp.2024-25-1.30","DOIUrl":"https://doi.org/10.36359/scivp.2024-25-1.30","url":null,"abstract":"High-yielding cows are prone to negative energy balance due to high lactation and insufficient dry matter intake after calving. This leads to the mobilization of fat and protein in the body to meet the nutrient needs of the lactating cow. High levels of nonesterified fatty acids are maintained by fat and protein mobilization, leading to ketosis due to incomplete oxidation of ketone bodies. The purpose of the research was to investigate the effect of probiotics on the productivity of cows and the quality of milk in ketosis. Research was conducted in the period from October to November 2021 on Holstein cows in the limited liability company \"Lan\" Agricultural Company of the North-Eastern region of Ukraine. It was found that in cows in the post-calving group, seven days after calving, the level of ketone bodies in the blood of the cows ranged from 1.0 to 2.1 mmol/l, which is higher than in the control by 71.42–185.71%. Two weeks after probiotic administration, ketone levels were between 0.5 and 1.2 mmol/L, 16.65–100% higher than controls. On the 28th day of the study, the content of ketone bodies in cows was within the physiological norm. In cows suffering from ketosis, productivity was reduced on the seventh day of research by 22.42–336.4%, on the 14th day by 11.6–29.35%. During the study of productivity, its restoration to the indicators of healthy animals on the 28th day after calving was established at the level of 28-29 kg/day. At the same time, the content of microorganisms and somatic cells had a direct correlation with productivity, and on the 28th day, the milk of all experimental cows was suitable for consumption and corresponded to the \"extra\" variety. \u0000In the first week after calving, the ratio of milk fat and protein in the milk of cows with ketosis was slightly imbalanced, which is a sign of ketosis. On the seventh day of the study, the milk fat level exceeded the protein content in cow 6905 by 32%, in cow 6852 by 39.25%, in cow 6916 by 30.34%, in cow 7642 by 41.17%, in cow 6187 – by 33.62%, in cow 2563 – by 36.40%, in cow 3891 – by 41.63%. At the end of the study on the 28th day, the fat/protein ratio approached the reference level of 1:1 in all experimental animals.","PeriodicalId":21617,"journal":{"name":"Scientific and Technical Bulletin оf State Scientific Research Control Institute of Veterinary Medical Products and Fodder Additives аnd Institute of Animal Biology","volume":"2 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140970386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"NOSOLOGICAL FEATURES OF INFECTIOUS ABORTIONS IN COWS","authors":"M. L. Radzyhovskyi, R. M. Sachuk, V. I. Koshevoy, O. V. Dyshkant, I. M. Sokulskyi, O. A. Katsaraba, O. Kulishenko, P. Davydenko, M. E. Ruda","doi":"10.36359/scivp.2024-25-1.18","DOIUrl":"https://doi.org/10.36359/scivp.2024-25-1.18","url":null,"abstract":"Providing the country's population with high-quality products is a priority task of modern animal husbandry. However, there are a number of problems in the industry that prevent obtaining quality products of animal origin in the required volume. The intensification of dairy farming and the increase in milk productivity of cows is often accompanied by a metabolic disorder, which reduces the body's resistance, contributing to the development of immune-deficiencies, which increase the susceptibility of animals to infectious diseases, some of which have an abortive form of manifestation and, accordingly, the consequence is a lack of offspring and potential income due to abortions. Abortion in cows should be considered not only as a gynecological problem, but also as an economic one, because animal husbandry accounts for more than 38% in the structure of gross agricultural products of the country and the lack of keeping of young animals significantly affects the development of the livestock industry. \u0000This publication is devoted to the results of the nosological profile of infectious abortions in cows on the territory of Ukraine, among which 64% of cases are infectious agents - 41.4% of bacterial origin and 22.6% of viral origin. The most frequent factors of bacterial etiology of abortions in cows are leptospira, coxiella, salmonella, mycoplasma, campylobacter, chlamydia, toxoplasma and listeria, and the most common viral ones are flavo-virus, gamma-herpesvirus and alpha-herpesvirus.","PeriodicalId":21617,"journal":{"name":"Scientific and Technical Bulletin оf State Scientific Research Control Institute of Veterinary Medical Products and Fodder Additives аnd Institute of Animal Biology","volume":"11 14","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140967036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"STUDY OF ACUTE AND SUB-ACUTE TOXICITY OF A MEDICATION BASED ON SPIDER VENOM EXTRACT","authors":"I. Patereha, V. Kushnir, O. Pyatnychko, V. Vynarchuk-Patereha, M. Chudyak","doi":"10.36359/scivp.2024-25-1.15","DOIUrl":"https://doi.org/10.36359/scivp.2024-25-1.15","url":null,"abstract":"Homeopathy is a regulatory therapy. The effectiveness of homeopathic therapy does not depend on the dose of the drug, but on the frequency of its repetitions. The composition of homeopathic preparations includes a wide range of natural and synthetic active substances: minerals; chemical substances; substances of plant origin; microorganisms, including fungi, bacteria, viruses, and plant parasites; substances of animal origin; and human materials, which may include tissues, secretions, hormones, and genetically homogeneous cell lines. \u0000One such substance is an extract of spider venom (Tarantul cubensis D6), which remains active in pharmaceutical preparation for a long time. The drug is selectively absorbed in inflamed tissues, differentiating them from healthy cells and suppressing inflammation. The drug is also effective in necrotic and proliferative processes. It is used for the treatment of panaritium in the initial stage, skin ulcers, necrobacillosis, and necrosis of the soft tissues of the animal. \u0000Any materials of animal or human origin are potentially dangerous for human and animal health, as they may contain toxic or pathogenic substances. Therefore, the study of the acute and subacute toxicity of spider venom extract is one of the stages of establishing the toxicological parameters of the drug. \u0000The use of the drug in a therapeutic dose caused an increase in animal body weight, hemoglobin concentration, number of leukocytes, erythrocytes, hematocrit value, average erythrocyte volume (MCV), average hemoglobin content in erythrocytes (МСН), average concentration of hemoglobin in erythrocytes (МСНС), number of platelets, and AST activity against the background of a slight decrease in total protein content, creatinine, urea, and ALT activity. \u0000The use of the drug in a 10-fold therapeutic dose caused an increase in animal body weight, creatinine, urea, ALT, and AST activity against the background of a decrease in the concentration of hemoglobin, the number of leukocytes and erythrocytes, the value of hematocrit, the average volume of erythrocytes (MCV), the average content of hemoglobin in erythrocytes (МСН), the average concentration of hemoglobin in erythrocytes (МСНС), the number of platelets, and the content of total protein.","PeriodicalId":21617,"journal":{"name":"Scientific and Technical Bulletin оf State Scientific Research Control Institute of Veterinary Medical Products and Fodder Additives аnd Institute of Animal Biology","volume":"29 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140968510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}