Obesity最新文献

{"title":"An eHealth Intervention in Pregnancy on Maternal Body Composition and Subsequent Perinatal Outcomes: A Randomized Trial","authors":"Maryam Kebbe,&nbsp;Kaja Falkenhain,&nbsp;Robbie Beyl,&nbsp;Abby D. Altazan,&nbsp;Emily W. Flanagan,&nbsp;Chelsea L. Kracht,&nbsp;Hannah E. Cabre,&nbsp;Emily K. Woolf,&nbsp;Daniel S. Hsia,&nbsp;John W. Apolzan,&nbsp;Leanne M. Redman","doi":"10.1002/oby.24357","DOIUrl":"10.1002/oby.24357","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>To examine the effects of a pragmatic multicomponent eHealth intervention in pregnancy on body composition changes and subsequent associations with perinatal outcomes.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Pregnant individuals (<i>n</i> = 351) enrolled in Louisiana's Women, Infants, and Children program were randomly assigned to a multicomponent eHealth Intervention or Usual Care. Fat percentage, fat mass, and fat-free mass were assessed using bioelectrical impedance at trimester-specific study visits. Mixed models evaluated within- and between-group differences in body composition from early to late pregnancy: overall, by BMI, and by gestational weight gain (GWG) guideline attainment. Effects of body composition changes on perinatal outcomes was evaluated.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Compared to Usual Care (<i>n</i> = 172), the Intervention Group (<i>n</i> = 179) had attenuated gains in fat mass, fat mass index, and fat percentage from early to late pregnancy overall, in individuals who had normal weight at enrollment, and in those who exceeded GWG guidelines (<i>p</i> &lt; 0.05). No significant between-group differences in fat-free mass were observed. Fat mass change interacted with intervention effects on neonatal health outcomes (<i>p</i> = 0.01).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Lifestyle interventions during pregnancy may attenuate gestational fat mass gain, particularly among women with normal weight and those who exceed GWG guidelines, with potential implications for neonatal health outcomes.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Trial Registration</h3>\u0000 \u0000 <p>\u0000 ClinicalTrials.gov identifier: NCT04028843</p>\u0000 </section>\u0000 </div>","PeriodicalId":215,"journal":{"name":"Obesity","volume":"33 9","pages":"1680-1693"},"PeriodicalIF":4.7,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144710413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk for cancer after bariatric surgery compared with the general population: a nationwide matched cohort study","authors":"Erik Stenberg,&nbsp;Johan Ottosson,&nbsp;Yang Cao,&nbsp;Ida Lagstam,&nbsp;Erik Näslund","doi":"10.1002/oby.24318","DOIUrl":"10.1002/oby.24318","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>Our objective was to evaluate how the incidence of cancer after metabolic and bariatric surgery (MBS) compared with the general population.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A nationwide cohort of patients who underwent MBS in Sweden from 2007 to 2020 were matched (age, sex, area of residence) to controls from the general population. All patients were followed for new incidence of cancer.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Among the 68,424 patients who underwent MBS compared with the 640,944 controls, there was no difference in the risk for new onset of cancer (incidence rate ratio [IRR]: 1.03, 95% CI: 0.99–1.07). Compared with controls, MBS was associated with a lower risk for breast cancer in women (IRR: 0.78, 95% CI: 0.71–0.86) and nonmelanoma (IRR: 0.71, 95% CI: 0.59–0.85) and melanoma (IRR: 0.77, 95% CI: 0.68–0.87) skin cancer in men and women, but an increased risk remained for colon cancer, liver cancer, pancreatic cancer, corpus uteri cancer, renal cancer, malignant meningioma, and non-Hodgkin's lymphoma.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>All-cancer incidence risk was similar between patients who underwent MBS and the general population. Although breast and skin cancer risk was lower among MBS patients compared with controls, MBS patients had a greater risk for multiple cancer types. Thus, patients who have undergone MBS should continue recommended cancer screening and clinically approved work-up for cancer symptoms as recommended for the general population.</p>\u0000 </section>\u0000 </div>","PeriodicalId":215,"journal":{"name":"Obesity","volume":"33 9","pages":"1725-1733"},"PeriodicalIF":4.7,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/oby.24318","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144700754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Breastfeeding, genetic susceptibility, and type 2 diabetes in offspring in later life","authors":"Ying Hu,&nbsp;Hao Ma,&nbsp;Xuan Wang,&nbsp;Shuqi Zhu,&nbsp;Danqing Chen,&nbsp;Zhaoxia Liang","doi":"10.1002/oby.24344","DOIUrl":"10.1002/oby.24344","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>Our objective was to assess the prospective association between breastfeeding and the risk of type 2 diabetes (T2D) in offspring and to investigate the joint effects of breastfeeding and genetic susceptibility on T2D risk.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We included 364,562 participants free from prevalent T2D from the UK Biobank. Cox proportional hazards models were employed to evaluate the association between breastfeeding and incident T2D.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Over a median follow-up of 12 years, 12,795 cases of incident T2D were recorded. Ever breastfeeding was associated with a significantly lower risk of T2D compared with never breastfeeding (hazard ratio = 0.94, 95% CI: 0.89–0.99). Additionally, significant interaction effects on T2D risk were observed between breastfeeding and T2D genetic risk score (T2D-GRS), both multiplicatively and additively. The association between T2D-GRS and risk of T2D was stronger in participants who were never breastfed compared with those who were breastfed (<i>p</i> for multiplicative interaction = 0.040). The risk of T2D associated with never breastfeeding combined with a high T2D-GRS was greater than the sum of the risks associated with each individual factor (<i>p</i> for additive interaction = 0.007).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Breastfeeding is associated with a lower risk of incident T2D in offspring, showing both multiplicative and additive interactions with T2D-GRS.</p>\u0000 </section>\u0000 </div>","PeriodicalId":215,"journal":{"name":"Obesity","volume":"33 9","pages":"1802-1809"},"PeriodicalIF":4.7,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/oby.24344","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144700753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to Hayashi et al.","authors":"Corby K. Martin,&nbsp;Hanim E. Diktas,&nbsp;Michelle I. Cardel,&nbsp;Monique M. LeBlanc,&nbsp;Stephanie L. Dickinson,&nbsp;Erin M. Ables,&nbsp;Xiwei Chen,&nbsp;Rebecca Nathan,&nbsp;Danielle Shapiro,&nbsp;Gary D. Foster","doi":"10.1002/oby.24351","DOIUrl":"10.1002/oby.24351","url":null,"abstract":"","PeriodicalId":215,"journal":{"name":"Obesity","volume":"33 9","pages":"1617-1618"},"PeriodicalIF":4.7,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144692790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early meal timing attenuates high polygenic risk of obesity","authors":"R De la Peña-Armada,&nbsp;María Rodríguez-Martín,&nbsp;Hassan S. Dashti,&nbsp;Ana Isabel Cascales,&nbsp;Frank A. J. L. Scheer,&nbsp;Richa Saxena,&nbsp;Marta Garaulet","doi":"10.1002/oby.24319","DOIUrl":"10.1002/oby.24319","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>We examined whether meal timing is associated with long-term weight-loss maintenance and whether meal timing interacts with a genome-wide polygenic score (PRS-BMI) on body weight-related outcomes. We then examined the interaction of meal timing with 97 BMI-related single-nucleotide polymorphisms on obesity outcome.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Participants (<i>N</i> = 1195, mean age 41.07 [SD 12.68] years, female 80.8%, baseline mean BMI 31.32 [SD 5.53] kg/m²) were adults with overweight or obesity from the Obesity, Nutrigenetics, Timing, and Mediterranean (ONTIME) study. We developed a PRS-BMI to assess the genetic risk for obesity and estimated the timing of the midpoint of meal intake. We also calculated the success in long-term weight-loss maintenance after a dietary obesity treatment (at least 3 years). Linear regression analyses were performed for association and interaction assessments.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Each hour of delay in meal timing was associated with 2.2% higher long-term body weight (β [SE] = 2.177% [1.067%]; <i>p</i> = 0.042) (i.e., with lower weight-loss maintenance following dietary obesity treatment). There was a significant interaction between meal timing and PRS-BMI (<i>p</i> = 0.008); BMI increased by more than 2 kg/m² for every hour of delay in meal timing in individuals with high PRS-BMI (β [SE] = 2.208 [0.502] kg/m²; <i>p</i> = 1.0E-5), whereas no associations were evident for those with lower genetic risk.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Meal timing is associated with weight-loss maintenance and may influence the association between obesity genetics and BMI. Findings underscore the importance of personalized obesity management.</p>\u0000 \u0000 <div>\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure>\u0000 </div>\u0000 </section>\u0000 </div>","PeriodicalId":215,"journal":{"name":"Obesity","volume":"33 8","pages":"1555-1566"},"PeriodicalIF":4.2,"publicationDate":"2025-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/oby.24319","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144677089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to “Development and Validation of the Food Noise Questionnaire”","authors":"Daisuke Hayashi,&nbsp;Caitlyn Edwards,&nbsp;Jennifer A. Emond,&nbsp;Diane Gilbert-Diamond,&nbsp;Ann M. Rogers,&nbsp;Andrea Rigby,&nbsp;Melissa Butt,&nbsp;Travis D. Masterson","doi":"10.1002/oby.24349","DOIUrl":"10.1002/oby.24349","url":null,"abstract":"","PeriodicalId":215,"journal":{"name":"Obesity","volume":"33 9","pages":"1615-1616"},"PeriodicalIF":4.7,"publicationDate":"2025-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144677091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gap of women leadership in global obesity research","authors":"Xiangxin Kong,&nbsp;Feifei Guo,&nbsp;Nan Hu,&nbsp;Wei Yang,&nbsp;Bosheng Ma,&nbsp;Furong Zhu,&nbsp;Yuan Yuan,&nbsp;Jia Xiao,&nbsp;Yixing Ren","doi":"10.1002/oby.24324","DOIUrl":"10.1002/oby.24324","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>This study aims to evaluate and summarize the current state of gender equality for female scientists in obesity research.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We conducted a comprehensive analysis of governmental funding, high-impact publications/citations, and awards received by female and male scientists engaged in obesity research worldwide. Median citations were compared by sex and year, with group differences assessed using the nonparametric Mann–Whitney <i>U</i> test.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Our findings reveal a concerning difference: In most representative countries, a higher proportion of male principal investigators received grant support, with Japan exhibiting the most pronounced gender bias. In highly cited obesity papers, female corresponding authors constituted only 33%, with Japan having the lowest representation at a mere 5%, whereas the Netherlands approached near-equal representation (49%). Furthermore, highly cited obesity papers authored by women generally received fewer citations than those by men across most analyzed years and countries. However, a positive trend emerged in awards: the European Association for the Study of Obesity and the Association for the Study of Obesity recognized female scientists at a higher rate than male scientists.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>These findings highlight a complex landscape. Although female scientists have gained increased support and recognition in several countries, significant gender inequality persists in obesity research.</p>\u0000 \u0000 <div>\u0000 \u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure>\u0000 </div>\u0000 </section>\u0000 </div>","PeriodicalId":215,"journal":{"name":"Obesity","volume":"33 9","pages":"1734-1744"},"PeriodicalIF":4.7,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/oby.24324","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144661480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Grip strength: are some adiposity phenotypes more detrimental than others? A Mendelian randomization study","authors":"Amy E. Taylor,&nbsp;John Vincent,&nbsp;Dylan M. Williams,&nbsp;Rachel Cooper,&nbsp;Snehal M. Pinto Pereira","doi":"10.1002/oby.24339","DOIUrl":"10.1002/oby.24339","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>Our objective was to investigate causal associations of adiposity in different locations and metabolically favorable and unfavorable adiposity (MetFA and MetUFA, respectively) with grip strength.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Observational cross-sectional and Mendelian randomization (MR) (sex combined and stratified) analysis within UK Biobank (<i>N</i> ≤ 340,258) was used to assess the relationships of visceral, abdominal subcutaneous, and gluteofemoral adipose tissue, anterior and posterior thigh muscle fat infiltration (ATMFI and PTMFI, respectively), body fat (BF) percentage, MetFA, and MetUFA with grip strength.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>In inverse variance weighted MR analysis, SD increases in BF, MetFA, and ATMFI were associated with lower grip strength by the following: −0.10 SD (95% CI: −0.16 to −0.04), −0.31 SD (95% CI: −0.45 to −0.18), and −0.05 SD (95% CI: −0.09 to −0.01), respectively. PTMFI associations aligned with ATMFI. Observational analyses were consistent for BF and ATMFI/PTMFI, but weighted median/mode MR corroborated findings for MetFA and ATMFI/PTMFI only. Higher visceral adipose tissue was associated with lower grip strength in observational analyses only. Associations for higher abdominal subcutaneous adipose tissue were inconsistent: Observational analyses suggested weaker grip; MR analyses suggested stronger grip, particularly in female individuals. There was no strong evidence in MR for associations with MetUFA or gluteofemoral adipose tissue.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Targeting fat infiltration in muscle may improve muscle function. MetFA appears to negatively impact muscle strength, requiring further investigation into underlying mechanisms.</p>\u0000 </section>\u0000 </div>","PeriodicalId":215,"journal":{"name":"Obesity","volume":"33 9","pages":"1779-1790"},"PeriodicalIF":4.7,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/oby.24339","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144651672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trends in prevalence of health and cardiovascular risk factors based on Life's Essential 8 among US adults, 2007–2020","authors":"Lixia Zhang,&nbsp;Yun Shen,&nbsp;Yibo Tang,&nbsp;Yihui Wu,&nbsp;Danqing Chen,&nbsp;Zhaoxia Liang,&nbsp;Gang Hu","doi":"10.1002/oby.24334","DOIUrl":"10.1002/oby.24334","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>This study aimed to determine trends in the prevalence of health factors and risk factors based on Life's Essential 8 (LE8) among US adults.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>The present study included 26,548 adults from the National Health and Nutrition Examination Survey in 2007–2008 to 2017–2020. Crude weighted prevalence and 95% CI values of individual risk and health factors based on LE8 were estimated by cycle, and their trends were assessed in logistic regression models.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>From 2007–2008 to 2017–2020, the prevalence of lack of physical activity (27.2% to 22.5%), current smoking (21.2% to 15.9%), less sleep time (37.1% to 22.7%), and hyperlipidemia (55.8% to 50.8%) decreased, and obesity (33.9% to 43.3%) and hypertension (31.5% to 34.6%) increased, whereas unhealthy diet and diabetes remained stable. There were significant increases in the prevalence of sufficient physical activity (59.7% to 66.7%), never smoking (50.3% to 55.5%), enough sleep time (56.8% to 60.6%), and normal blood lipids (30.2% to 35.6%) and significant decreases in the prevalence of normal weight (30.8% to 25.7%), normal blood glucose (71.5% to 64.8%), and normal blood pressure (61.3% to 58.7%).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>This study found improvement in physical activity, smoking, sleep health, and blood lipids and worsening of weight, blood glucose, and blood pressure among US adults from 2007–2008 to 2017–2020.</p>\u0000 </section>\u0000 </div>","PeriodicalId":215,"journal":{"name":"Obesity","volume":"33 9","pages":"1756-1764"},"PeriodicalIF":4.7,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144651674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Benefits of Krill Oil Supplementation During Alternate-Day Fasting in Adults With Overweight and Obesity: A Randomized Trial","authors":"Mansour Alblaji,&nbsp;Stuart R. Gray,&nbsp;Taibah Almesbehi,&nbsp;Douglas J. Morrison,&nbsp;Dalia Malkova","doi":"10.1002/oby.24354","DOIUrl":"10.1002/oby.24354","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>To investigate the effect of krill oil (KO) supplementation during alternate-day fasting (ADF) on body composition and muscle function in healthy adults with overweight.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>In a randomized trial, during the 8-week ADF, participants consumed four capsules per day containing krill oil (KO group) or vegetable oil (placebo group). Each capsule of KO contained 191 mg EPA, 94 mg DHA, 78 mg choline, and 100 mcg astaxanthin. Body mass, fat-free mass (FFM), and handgrip strength (HGS) were measured before and after the intervention. Data were analyzed using ANOVA.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The study was completed by 41 (25 women and 16 men) participants (age: 39 ± 10 years, BMI: 31.1 ± 4.2 kg/m²). Body weight reduction was not different (<i>p</i> &gt; 0.05) between groups (KO, −4.6 ± 1.4 kg; Placebo, −4.5 ± 1.9 kg). The KO group had no change (<i>p</i> &gt; 0.05) in FFM (−0.2 ± 0.9 kg) or HGS (−0.2 ± 0.5 kg). The placebo group experienced a reduction (<i>p</i> &lt; 0.05) in FFM (−1.2 ± 2.0 kg) and HGS (−0.9 ± 0.7 kg). Changes in FFM and HGS were different (<i>p</i> &lt; 0.05) between groups.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>KO supplementation during body weight loss attenuates the decline in FFM and muscle strength.</p>\u0000 \u0000 <p>\u0000 <b>Trial Registration:</b> ClinicalTrials.gov Identifier (NCT06001632)</p>\u0000 </section>\u0000 </div>","PeriodicalId":215,"journal":{"name":"Obesity","volume":"33 9","pages":"1694-1703"},"PeriodicalIF":4.7,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/oby.24354","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144651671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}