Science China Life Sciences最新文献

{"title":"Spatiotemporal transcriptomics unveil gelsolin as a critical regulator in ventricular remodeling after myocardial infarction.","authors":"Wenting Wang, Yanfei Liu, Longkun Liu, Qian Xu, Yiwen Li, Mengmeng Zhu, Jing Cui, Keji Chen, Yue Liu","doi":"10.1007/s11427-024-2806-2","DOIUrl":"https://doi.org/10.1007/s11427-024-2806-2","url":null,"abstract":"","PeriodicalId":21576,"journal":{"name":"Science China Life Sciences","volume":" ","pages":""},"PeriodicalIF":8.0,"publicationDate":"2024-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142897202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing the ecological effects of the World's Largest Forestry Eco-engineering: Three-North Protective Forest Program within the initially scheduled range from 1978 to 2022.","authors":"Xiao Zheng, Jiaojun Zhu, G Geoff Wang, Qiaoling Yan, Tao Sun, Lining Song, Tian Gao, Yirong Sun, Xiufen Li, Kai Yang, Jinxin Zhang, Lizhong Yu, Ke Qi, Lanlin Zhao, Deliang Lu, Zhanyuan Lu","doi":"10.1007/s11427-024-2705-4","DOIUrl":"https://doi.org/10.1007/s11427-024-2705-4","url":null,"abstract":"<p><p>China's Three-North Protective Forest Program (TNP) is the world's most ambitious afforestation project (ongoing from 1978 to 2050), which aims to increase forest coverage through afforestation and reforestation, protect agriculture, reduce soil erosion, and control desertification. Although TNP has been ongoing for 45 years, its rationales and effects remain uncertain. Here, we conducted a range-wide assessment of TNP by analyzing data from >10,000 scenes of satellite images and >50,000 field survey plots. The TNP range and definitions of shelterbelts, arboreal forests, and shrublands were changed during the study period, but we used the initial TNP range (4.07 million km²) and the definitions in 1978 for keeping the consistency, comparability, and comprehensiveness. The TNP increased forest coverage from 5.05% in 1978 to 9.69% in 2022, with arboreal forests, shrublands, and shelterbelts increasing by 42.5%, 184.4%, and 53.6%, respectively. However, only 40.1% of the 471,113 km² afforested area was established between 1978 and 2022. The well-established shelterbelts improved crop yield by 4.3%-9.5%, but only 10.2% of all the farmlands in TNP regions (TNR) were protected. The total area of soil erosion due to hydraulic forces was reduced by 447,363 km², with 61% of this reduction attributed to TNP. TNP contributed to the reduction of desertification by 15%, largely due to the low rate of afforestation success and the largely decreased grasslands. The total carbon sequestration from TNP was 1.96 Pg C. Moreover, water storage in TNR showed a decreasing trend, but the contribution rate of TNP was only 7.8%. Our results illustrate that forestry eco-engineering projects are feasible in the management and restoration of arid and semi-arid degraded lands, but attention must be paid to fully considering the ecological carrying capacity of water resources, matching the species to sites, strengthening the post-afforestation management, as well as keeping the balances between composite ecosystems.</p>","PeriodicalId":21576,"journal":{"name":"Science China Life Sciences","volume":" ","pages":""},"PeriodicalIF":8.0,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142897186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A haplotype-resolved genome assembly of tetraploid Medicago sativa ssp. falcata.","authors":"Wanying Li, Xuanzhao Li, Wei Li, Haibo Yang, Diandian Guo, Ting Guo, Yingying Meng, Qiang He, Hao Lin, Huilong Du, Lifang Niu","doi":"10.1007/s11427-024-2753-2","DOIUrl":"https://doi.org/10.1007/s11427-024-2753-2","url":null,"abstract":"","PeriodicalId":21576,"journal":{"name":"Science China Life Sciences","volume":" ","pages":""},"PeriodicalIF":8.0,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142897184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advances and applications in single-cell and spatial genomics.","authors":"Jingjing Wang, Fang Ye, Haoxi Chai, Yujia Jiang, Teng Wang, Xia Ran, Qimin Xia, Ziye Xu, Yuting Fu, Guodong Zhang, Hanyu Wu, Guoji Guo, Hongshan Guo, Yijun Ruan, Yongcheng Wang, Dong Xing, Xun Xu, Zemin Zhang","doi":"10.1007/s11427-024-2770-x","DOIUrl":"https://doi.org/10.1007/s11427-024-2770-x","url":null,"abstract":"<p><p>The applications of single-cell and spatial technologies in recent times have revolutionized the present understanding of cellular states and the cellular heterogeneity inherent in complex biological systems. These advancements offer unprecedented resolution in the examination of the functional genomics of individual cells and their spatial context within tissues. In this review, we have comprehensively discussed the historical development and recent progress in the field of single-cell and spatial genomics. We have reviewed the breakthroughs in single-cell multi-omics technologies, spatial genomics methods, and the computational strategies employed toward the analyses of single-cell atlas data. Furthermore, we have highlighted the advances made in constructing cellular atlases and their clinical applications, particularly in the context of disease. Finally, we have discussed the emerging trends, challenges, and opportunities in this rapidly evolving field.</p>","PeriodicalId":21576,"journal":{"name":"Science China Life Sciences","volume":" ","pages":""},"PeriodicalIF":8.0,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142954214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Profile of Chao Liu.","authors":"","doi":"10.1007/s11427-024-2723-8","DOIUrl":"https://doi.org/10.1007/s11427-024-2723-8","url":null,"abstract":"","PeriodicalId":21576,"journal":{"name":"Science China Life Sciences","volume":" ","pages":""},"PeriodicalIF":8.0,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142865262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Not just a combination: a fully-integrated strategy of cellular therapy for acute myeloid leukemia expressing CD7, a heretofore elusive target.","authors":"Norbert-Claude Gorin","doi":"10.1007/s11427-024-2711-y","DOIUrl":"https://doi.org/10.1007/s11427-024-2711-y","url":null,"abstract":"","PeriodicalId":21576,"journal":{"name":"Science China Life Sciences","volume":" ","pages":""},"PeriodicalIF":8.0,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142897195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unlocking lignin valorization and harnessing lignin-based raw materials for bio-manufacturing.","authors":"Le Gao, Fangting Jiang, Zhaokun Zhang, Tongtong Bao, Daochen Zhu, Xin Wu","doi":"10.1007/s11427-024-2792-x","DOIUrl":"https://doi.org/10.1007/s11427-024-2792-x","url":null,"abstract":"<p><p>Lignin, an energy-rich and adaptable polymer comprising phenylpropanoid monomers utilized by plants for structural reinforcement, water conveyance, and defense mechanisms, ranks as the planet's second most prevalent biopolymer, after cellulose. Despite its prevalence, lignin is frequently underused in the process of converting biomass into fuels and chemicals. Instead, it is commonly incinerated for industrial heat due to its intricate composition and resistance to decomposition, presenting obstacles for targeted valorization. In contrast to chemical catalysts, biological enzymes show promise not only in selectively converting lignin components but also in seamlessly integrating into cellular structures, offering biocatalysis as a potentially efficient pathway for lignin enhancement. This review comprehensively summarizes cutting-edge biostrategies, ligninolytic enzymes, metabolic pathways, and lignin-degrading strains or consortia involved in lignin degradation, while critically evaluating the underlying mechanisms. Metabolic and genetic engineering play crucial roles in redirecting lignin and its derivatives towards metabolic pathways like the tricarboxylic acid cycle, opening up novel avenues for its valorization. Recent advancements in lignin valorization are scrutinized, highlighting key challenges and promising solutions. Furthermore, the review underscores the importance of innovative approaches, such as leveraging digital systems and synthetic biology, to unlock the commercial potential of lignin-derived raw materials as sustainable feedstocks. Artificial intelligence-driven technologies offer promise in overcoming current challenges and driving widespread adoption of lignin valorization, presenting an alternative to sugar-based feedstocks for bio-based manufacturing in the future. The utilization of available lignin residue for synthesis of high-value chemicals or energy, even alternative food, addresses various crises looming in the food-energy-water nexus.</p>","PeriodicalId":21576,"journal":{"name":"Science China Life Sciences","volume":" ","pages":""},"PeriodicalIF":8.0,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142865266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Homozygous deleterious variants in MYCBPAP induce asthenoteratozoospermia involving abnormal acrosome biogenesis, manchette structure and sperm tail assembly in humans and mice.","authors":"Yiling Zhou, Chaofeng Tu, Charles Coutton, Jianan Tang, Shixiong Tian, Shuyan Tang, Guillaume Martinez, Dapeng Zhou, Célia Tebbakh, Jiaxiong Wang, Raoudha Zouari, Xuehai Zhou, Selima Fourati Ben Mustapha, Xuemei Wang, Bangguo Wu, Xinyan Geng, Shuang Liu, Li Jin, Huijuan Shi, Yue-Qiu Tan, Pierre F Ray, Lingbo Wang, Xiaoyu Yang, Feng Zhang, Chunyu Liu","doi":"10.1007/s11427-024-2757-7","DOIUrl":"https://doi.org/10.1007/s11427-024-2757-7","url":null,"abstract":"<p><p>Asthenoteratozoospermia is a common cause of male infertility. To further define the genetic causes underlying asthenoteratozoospermia, we performed whole-exome sequencing in a cohort of Han Chinese men with asthenoteratozoospermia. Homozygous deleterious variants of MYCBPAP were first identified in two unrelated Chinese cases. Replication analyses in a French cohort revealed an additional asthenoter-atozoospermia-affected case harboring a homozygous nonsense variant in MYCBPAP. All of the identified MYCBPAP variants were absent or extremely rare in the public human genome databases. Further functional assays indicated remarkably reduced abundance of MYCBPAP in the spermatozoa from MYCBPAP-associated cases. Subsequently, we generated a Mycbpap knockout (Mycbpap^-/-) mouse model, which also exhibited male infertility with reduced sperm motility and abnormal morphologies in sperm heads and flagella. Further investigations demonstrated that Mycbpap^-/- male mice presented disrupted acrosome biogenesis and abnormally elongated manchette during spermiogenesis. Intriguingly, proteomic analyses indicated that the proteins related to spermatogenesis, acrosomal and flagellar functions were significantly down-regulated in the testes from Mycbpap^-/- male mice. Endogenous immunoprecipitation combined with mass spectrometry revealed interactions of MYCBPAP with a ribosome elimination related protein ARMC3 and central apparatus proteins including CFAP65 and CFAP70. Furthermore, MYCBPAP-associated male infertility in humans and mice could be partially overcome by using intracytoplasmic sperm injections. Collectively, these findings illustrate the essential role of MYCBPAP in normal spermatogenesis and homozygous deleterious variants in MYCBPAP can be considered as a genetic diagnostic indicator for infertile men with asthenoteratozoospermia. Our study will provide effective guidance for genetic counseling, clinical diagnosis and assisted reproduction treatments of MYCBPAP-associated male infertility.</p>","PeriodicalId":21576,"journal":{"name":"Science China Life Sciences","volume":" ","pages":""},"PeriodicalIF":8.0,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142865244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gut microbiota's role in high-altitude cognitive impairment: the therapeutic potential of Clostridium sp. supplementation.","authors":"Wei Zhou, Yongqiang Zhou, Shikun Zhang, Bin Li, Zhong Li, Zhijie Bai, Dezhi Sun, Chaoji Huangfu, Ningning Wang, Tiantian Xia, Congshu Huang, Lina Guan, Xi Yang, Yangyi Hu, Pengfei Zhang, Pan Shen, Rui Wang, Zhexin Ni, Yue Gao","doi":"10.1007/s11427-024-2779-9","DOIUrl":"https://doi.org/10.1007/s11427-024-2779-9","url":null,"abstract":"<p><p>Prolonged exposure to high-altitude environments may increase the risk of cognitive decline in young migrants. Recent studies suggest that hypobaric hypoxia-induced alterations in gut microbial composition could partly contribute to this risk. However, the absence of direct evidence from cohort studies and an unclear mechanism hinder intervention development based on this hypothesis. This study recruited 109 young male migrants living in Xizang to investigate the microbial mechanisms underlying cognitive impairment associated with high-altitude migration. Multi-omic analysis revealed distinct microbiome and metabolome features in migrants with cognitive decline, notably a reduced abundance of Clostridium species and disrupted fecal absorption of L-valine. Mechanistic studies showed that hypobaric hypoxia significantly damaged the intestinal barrier, leading to lipopolysaccharide (LPS) leakage and an influx of inflammatory factors into the peripheral blood, which activated microglia and caused neuronal injury in the hippocampus of mice. Additionally, compromised L-valine absorption due to intestinal barrier damage correlated with lower hippocampal glutamate levels and neurotrophic factors. Intervention with Clostridium sp. effectively restored the intestinal barrier and enhanced L-valine absorption, which mitigated hypobaric hypoxia-induced inflammation and hippocampal neural damage in mice. In conclusion, cognitive impairment among young migrants at high altitude may be attributed to hypobaric hypoxia-induced gut microbiota disruption and subsequent intestinal barrier dysfunction. This study may provide a promising approach for preventing and treating high-altitude-associated cognitive impairment.</p>","PeriodicalId":21576,"journal":{"name":"Science China Life Sciences","volume":" ","pages":""},"PeriodicalIF":8.0,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142865181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tissue-specific inhibition of brassinosteroids regulates panicle branching and grain yield in rice.","authors":"Faisal Islam, Muhammad Saad Shoaib Khan, Xiaoyu Guo, Daowen Wang, Guang Qi","doi":"10.1007/s11427-024-2747-4","DOIUrl":"https://doi.org/10.1007/s11427-024-2747-4","url":null,"abstract":"","PeriodicalId":21576,"journal":{"name":"Science China Life Sciences","volume":" ","pages":""},"PeriodicalIF":8.0,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142829775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}