Science China Life Sciences最新文献_第4页

Lifetime probabilities of developing and dying from cancer in China: comparison with Japan and the United States in 2022.

IF 8 2区生物学

Science China Life Sciences Pub Date : 2025-02-26 DOI: 10.1007/s11427-024-2810-y

Qian Zhu, Yifei Yao, Ru Chen, Bingfeng Han, Shaoming Wang, Li Li, Kexin Sun, Rongshou Zheng, Wenqiang Wei

{"title":"Lifetime probabilities of developing and dying from cancer in China: comparison with Japan and the United States in 2022.","authors":"Qian Zhu, Yifei Yao, Ru Chen, Bingfeng Han, Shaoming Wang, Li Li, Kexin Sun, Rongshou Zheng, Wenqiang Wei","doi":"10.1007/s11427-024-2810-y","DOIUrl":"https://doi.org/10.1007/s11427-024-2810-y","url":null,"abstract":"The numbers of new cancer cases and deaths in China were the largest in the world, causing a huge social and economic burden. We attempt to use more intuitive indicators to measure the probabilities of being diagnosed of or dying from cancer in China and compare these probabilities with those in Japan and the United States (US). We obtained the cancer data from GLOBOCAN 2022 for China, Japan, and the US and the all-cause mortality and population data from the United Nations. The lifetime risks of developing and dying from cancer were estimated with adjusted actual life expectancy, multiple primaries, and death-competing risks from causes other than cancers. Approximately 27.61% of Chinese people developed cancer and 1 in 5 persons were likely to die from cancer. The highest-risk cancer among men and women was lung cancer in China, but in the US and Japan, prostate cancer among men and breast cancer among women posed the highest risk. Lung cancer presented the highest likelihood of death, but women in Japan had the highest likelihood of dying from colorectal cancer. China had a lower lifetime risk of developing cancer compared with Japan and the US, but a higher probability of dying from cancer than the US. Although the probability of developing cancer was not as high as that in Japan and the US, China was still faced with enormous pressure due to its huge population and contradictory cancer patterns. Estimating lifetime risks can provide essential information to formulate appropriate cancer prevention and control plans.","PeriodicalId":21576,"journal":{"name":"Science China Life Sciences","volume":" ","pages":""},"PeriodicalIF":8.0,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143543273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Generation of transient totipotent blastomere-like stem cells by short-term high-dose Pladienolide B treatment.

IF 8 2区生物学

Science China Life Sciences Pub Date : 2025-02-26 DOI: 10.1007/s11427-024-2774-2

Wenyi Zhang, Shiyu An, Shuyue Hou, Xingsi He, Jinfeng Xiang, Huanyu Yan, Xiaorui Liu, Lingling Dong, Xi Wang, Yang Yang

{"title":"Generation of transient totipotent blastomere-like stem cells by short-term high-dose Pladienolide B treatment.","authors":"Wenyi Zhang, Shiyu An, Shuyue Hou, Xingsi He, Jinfeng Xiang, Huanyu Yan, Xiaorui Liu, Lingling Dong, Xi Wang, Yang Yang","doi":"10.1007/s11427-024-2774-2","DOIUrl":"https://doi.org/10.1007/s11427-024-2774-2","url":null,"abstract":"As an alternative model for studying the dynamic process of early mammalian embryonic development, much progress has been made in using mouse embryonic stem cells (mESCs) to generate embryo-like structures, especially by modifying the starting cells. A previous study has demonstrated that totipotent blastomere-like cells (TBLCs) can be obtained by continuous treatment of mESCs with a low-dose splicing inhibitor, Pladienolide B (PlaB). However, these totipotent mESCs have limited proliferative capacity. Here, we report that short-term high-dose PlaB treatment can also induce mESCs to acquire totipotency. This treatment equips this novel type of stem cells with the ability to self-organize into blastoids and recapitulate key preimplantation developmental processes. Therefore, the stem cells are termed transient totipotent blastomere-like stem cells (tTBLCs). Transcriptome analysis showed that tTBLC blastoids bore similarities to mouse E3.5 blastocysts, E4.5 blastocysts, and TBLC blastoids. Additionally, we found that tTBLC blastoids could develop beyond the implantation stage, forming egg-cylinder-like structures both in vitro and in vivo. In summary, our research provides an alternative rapid and convenient method to generate the starting cells capable of developing into blastoids, which have immense application in various fields, not only in the basic study of early mouse embryogenesis but also in high-throughput drug screening.","PeriodicalId":21576,"journal":{"name":"Science China Life Sciences","volume":" ","pages":""},"PeriodicalIF":8.0,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143537629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Natural polymorphisms of COOL1 contribute to cold tolerance adaptation in maize.

IF 8 2区生物学

Science China Life Sciences Pub Date : 2025-02-20 DOI: 10.1007/s11427-025-2871-4

Xianwei Song, Xiaofeng Cao

引用次数: 0

Claudin-11 plays a pivotal role in the clathrin-mediated endocytosis of influenza A virus.

IF 8 2区生物学

Science China Life Sciences Pub Date : 2025-02-20 DOI: 10.1007/s11427-024-2856-y

Xiaofei Yu, Zixin Ni, Yifan Wang, Jingfei Wang, Guohua Deng, Jianzhong Shi, Huihui Kong, Yongping Jiang, Guobin Tian, Chengjun Li, Yoshihiro Kawaoka, Hualan Chen, Jinliang Wang

{"title":"Claudin-11 plays a pivotal role in the clathrin-mediated endocytosis of influenza A virus.","authors":"Xiaofei Yu, Zixin Ni, Yifan Wang, Jingfei Wang, Guohua Deng, Jianzhong Shi, Huihui Kong, Yongping Jiang, Guobin Tian, Chengjun Li, Yoshihiro Kawaoka, Hualan Chen, Jinliang Wang","doi":"10.1007/s11427-024-2856-y","DOIUrl":"https://doi.org/10.1007/s11427-024-2856-y","url":null,"abstract":"Identification of host factors that play a key role in viral replication is of great importance for antiviral development. Metabotropic glutamate receptor subtype 2 (mGluR2) is the receptor to trigger clathrin-mediated endocytosis (CME), the major pathway by which influenza virus enters cells. However, other host factors almost certainly involved in the influenza virus CME are largely unknown. Here, we found that the four-transmembrane protein claudin-11 plays an integral part in influenza virus CME. Claudin-11 promotes the dissociation of KCa1.1 (potassium calcium-activated channel subfamily M alpha 1) from mGluR2 and, together with mGluR2, is internalized in virus-containing clathrin-coated pits (CCPs), where it regulates the depolymerization of polymerized F-actin, allowing the CCPs to mature. Importantly, over 60% of claudin-11-silenced mice survived infection with a lethal influenza virus. Our findings advance the understanding of influenza virus infection and provide a promising strategy for the development of host-based antiviral drugs.","PeriodicalId":21576,"journal":{"name":"Science China Life Sciences","volume":" ","pages":""},"PeriodicalIF":8.0,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143476726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Redox state of NAD modulates the activation of Na-bicarbonate cotransporter NBCe1-B via IRBIT and L-IRBIT.

IF 8 2区生物学

Science China Life Sciences Pub Date : 2025-02-20 DOI: 10.1007/s11427-024-2750-0

Tianxiang Gui, Ying Liu, Mingfeng Fu, Han Wu, Pan Su, Xuhui Feng, Mengmeng Zheng, Zixuan Huang, Xudong Luo, Walter F Boron, Li-Ming Chen

{"title":"Redox state of NAD modulates the activation of Na-bicarbonate cotransporter NBCe1-B via IRBIT and L-IRBIT.","authors":"Tianxiang Gui, Ying Liu, Mingfeng Fu, Han Wu, Pan Su, Xuhui Feng, Mengmeng Zheng, Zixuan Huang, Xudong Luo, Walter F Boron, Li-Ming Chen","doi":"10.1007/s11427-024-2750-0","DOIUrl":"https://doi.org/10.1007/s11427-024-2750-0","url":null,"abstract":"Nicotinamide adenine dinucleotide (NAD) is well known as a coenzyme involved in many redox reactions in cellular energy metabolism, or as a substrate for many NAD+-consuming enzymes, including those that generate the second messenger cyclic ADP-ribose or deacetylate proteins (e.g., histones). The role of NAD in non-catalytic proteins is poorly understood. IRBIT and L-IRBIT (the IRBITs) are two cytosolic proteins that are structurally related to dehydrogenases but lack catalytic activity. Instead, by interacting directly with their targets, the IRBITs modulate the function of numerous proteins with important roles, ranging from Ca2+ signaling and intracellular pH (pHi) regulation to DNA metabolism to autophagy. Among the targets of the IRBITs is the Na+-HCO3- cotransporter NBCe1-B, which plays a central role in intracellular pH (pHi) regulation and epithelial electrolyte transport. Here, we demonstrate that NAD modulates NBCe1-B activation by serving as a cofactor of IRBIT or L-IRBIT. Blocking NAD salvage pathway greatly decreases NBCe1-B activation by the IRBITs. Administration of the oxidized form NAD+ enhances, whereas the reduced form NADH decreases NBCe1-B activity. Our study represents the first example in which the redox state of NAD, via IRBIT or L-IRBIT, modulates the function of a membrane transport protein. Our findings reveal a new role of NAD and greatly expand our understanding of NAD biology. Because the NAD redox state fluctuates greatly with metabolic status, our work provides insight into how, via the IRBITs, energy metabolism could affect pHi regulation and many other IRBIT-dependent processes.","PeriodicalId":21576,"journal":{"name":"Science China Life Sciences","volume":" ","pages":""},"PeriodicalIF":8.0,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143476740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Osmosensor TMEM63B facilitates insulin secretion in pancreatic β-cells.

IF 8 2区生物学

Science China Life Sciences Pub Date : 2025-02-20 DOI: 10.1007/s11427-024-2833-3

Jing-Jing Tu, Chang Ye, Xiao-Yu Teng, Yan-Yu Zang, Xiao-Ye Sun, Shuai Chen, Jiang Chen, Yun Stone Shi

引用次数: 0

3D facial imaging: a novel approach for metabolic abnormalities risk profiling.

IF 8 2区生物学

Science China Life Sciences Pub Date : 2025-02-18 DOI: 10.1007/s11427-024-2726-8

Qianqian Peng, Yam Ki Cheung, Yu Liu, Yiyang Wang, Jingze Tan, Yajun Yang, Jiucun Wang, Jing-Dong J Han, Li Jin, Fan Liu, Sijia Wang

{"title":"3D facial imaging: a novel approach for metabolic abnormalities risk profiling.","authors":"Qianqian Peng, Yam Ki Cheung, Yu Liu, Yiyang Wang, Jingze Tan, Yajun Yang, Jiucun Wang, Jing-Dong J Han, Li Jin, Fan Liu, Sijia Wang","doi":"10.1007/s11427-024-2726-8","DOIUrl":"https://doi.org/10.1007/s11427-024-2726-8","url":null,"abstract":"The human face harbors a rich tapestry of complex phenotypic information spanning genetic, environmental, and physiological dimensions. While facial images excel in diagnosing genetic diseases, their untapped potential for predicting metabolic health presents an intriguing prospect. Metabolic Syndrome (MetS), marked by a constellation of metabolic abnormalities, poses a significant risk for various chronic diseases. Utilizing Face-Wide Association Studies (FaWAS) on a discovery cohort of 2,621 Chinese individuals and a replication cohort of 2,188 Chinese individuals, we investigated the associations between facial features and MetS and its related conditions. Our findings highlight half of our investigated facial features strongly correlated with MetS risk, such as a slender forehead, a broader and shorter jawline, and fuller features around the temples-eye-cheek region, with notable genetic correlations (0.55-0.58) and influences from environmental factors like age, urban residency, and educational level. The developed face-based prediction model demonstrated significant predictive robustness, achieving an AUC of up to 0.87 for MetS and 0.89 for obesity in external validations, surpassing traditional 2D imaging techniques. Our model also aids in identifying subtypes within healthy populations, with a 2.07 to 2.40-fold increased risk of developing different metabolic disorders within the next five years. This paves the way for precise risk stratification of individuals who are \"at risk\". Integrating 3D facial imaging for metabolic health predictions, our research introduces an innovative, non-invasive framework for health assessment and subtype identification, demonstrating high potential in personalized medicine and health monitoring.","PeriodicalId":21576,"journal":{"name":"Science China Life Sciences","volume":" ","pages":""},"PeriodicalIF":8.0,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143459483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Profile of Dr. Hang Sun.

IF 8 2区生物学

Science China Life Sciences Pub Date : 2025-02-17 DOI: 10.1007/s11427-024-2815-2

引用次数: 0

Profile of Dr. Shaorong Gao.

IF 8 2区生物学

Science China Life Sciences Pub Date : 2025-02-17 DOI: 10.1007/s11427-024-2689-5

引用次数: 0

Mitochondrial antigens: their presentation and related diseases.

IF 8 2区生物学

Science China Life Sciences Pub Date : 2025-02-17 DOI: 10.1007/s11427-024-2781-x

Shiyang Zhang, Shicheng Su

引用次数: 0