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Identification of EPOR and JAK2 double heterozygous variants in twin cases with familial erythrocytosis. 家族性红细胞增多症双胞胎病例中 EPOR 和 JAK2 双杂合子变体的鉴定。
IF 8 2区 生物学
Science China Life Sciences Pub Date : 2024-12-11 DOI: 10.1007/s11427-024-2786-5
Wenqian Li, Guoxiong Han, Xiaorui Wang, Kuo Shen, Youbang Xie
{"title":"Identification of EPOR and JAK2 double heterozygous variants in twin cases with familial erythrocytosis.","authors":"Wenqian Li, Guoxiong Han, Xiaorui Wang, Kuo Shen, Youbang Xie","doi":"10.1007/s11427-024-2786-5","DOIUrl":"https://doi.org/10.1007/s11427-024-2786-5","url":null,"abstract":"","PeriodicalId":21576,"journal":{"name":"Science China Life Sciences","volume":" ","pages":""},"PeriodicalIF":8.0,"publicationDate":"2024-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142819107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Histone methylation reprogramming underpins gene expression dynamics in Phytophthora during host infection.
IF 8 2区 生物学
Science China Life Sciences Pub Date : 2024-12-11 DOI: 10.1007/s11427-024-2780-4
Haidong Shu, Guoyu Yin, Meihui Wu, Yujie Fang, Yufeng Fang, Yuanchao Wang, Han Chen, Suomeng Dong
{"title":"Histone methylation reprogramming underpins gene expression dynamics in Phytophthora during host infection.","authors":"Haidong Shu, Guoyu Yin, Meihui Wu, Yujie Fang, Yufeng Fang, Yuanchao Wang, Han Chen, Suomeng Dong","doi":"10.1007/s11427-024-2780-4","DOIUrl":"https://doi.org/10.1007/s11427-024-2780-4","url":null,"abstract":"","PeriodicalId":21576,"journal":{"name":"Science China Life Sciences","volume":" ","pages":""},"PeriodicalIF":8.0,"publicationDate":"2024-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142819106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Microbial production of chondroitin sulfate and its derivatives.
IF 8 2区 生物学
Science China Life Sciences Pub Date : 2024-12-10 DOI: 10.1007/s11427-024-2805-1
Jine Li, Jihui Zhang, Huarong Tan
{"title":"Microbial production of chondroitin sulfate and its derivatives.","authors":"Jine Li, Jihui Zhang, Huarong Tan","doi":"10.1007/s11427-024-2805-1","DOIUrl":"https://doi.org/10.1007/s11427-024-2805-1","url":null,"abstract":"","PeriodicalId":21576,"journal":{"name":"Science China Life Sciences","volume":" ","pages":""},"PeriodicalIF":8.0,"publicationDate":"2024-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142812968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Regulation and application of m6A modification in tumor immunity.
IF 8 2区 生物学
Science China Life Sciences Pub Date : 2024-12-06 DOI: 10.1007/s11427-024-2648-0
Qunli Xiong, Yaguang Zhang, Ying Zheng, Qing Zhu
{"title":"Regulation and application of m<sup>6</sup>A modification in tumor immunity.","authors":"Qunli Xiong, Yaguang Zhang, Ying Zheng, Qing Zhu","doi":"10.1007/s11427-024-2648-0","DOIUrl":"https://doi.org/10.1007/s11427-024-2648-0","url":null,"abstract":"<p><p>The m<sup>6</sup>A modification is an RNA modification that impacts various processes of RNA molecules, including transcription, splicing, stability, and translation. Recently, researchers have discovered that the presence of m<sup>6</sup>A modification can influence the interaction between tumor cells and immune cells and also play a role in regulating the expression of immune response-related genes. Additionally, m<sup>6</sup>A modification is intricately involved in the regulation of tumor immune evasion and drug resistance. Specifically, certain tumor cells can manipulate the gene expression through m<sup>6</sup>A modification to evade immune system attacks. Therefore, it might be possible to enhance tumor immune surveillance and improve the effectiveness of immune-based therapies by manipulating m<sup>6</sup>A modification. This review systematically discusses the role of m<sup>6</sup>A modification in tumor immunity, specifically highlighting its regulation of immune cells and immune-related genes in tumor cells. Furthermore, we explore the potential of m<sup>6</sup>A modification inhibitors as anti-cancer therapies and the significance of m<sup>6</sup>A regulatory factors in predicting the efficacy of tumor immune therapy.</p>","PeriodicalId":21576,"journal":{"name":"Science China Life Sciences","volume":" ","pages":""},"PeriodicalIF":8.0,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142795106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hox-determined appendage regeneration restores cockroach courtship rituals.
IF 8 2区 生物学
Science China Life Sciences Pub Date : 2024-12-05 DOI: 10.1007/s11427-024-2767-3
Xingmei Mai, Mingtao Liao, Fangming Zhao, Ethan Yihao Li, Fangzheng Liu, Renaguli Aisa, Sichen Wu, Nan Chen, Sheng Li, Chonghua Ren
{"title":"Hox-determined appendage regeneration restores cockroach courtship rituals.","authors":"Xingmei Mai, Mingtao Liao, Fangming Zhao, Ethan Yihao Li, Fangzheng Liu, Renaguli Aisa, Sichen Wu, Nan Chen, Sheng Li, Chonghua Ren","doi":"10.1007/s11427-024-2767-3","DOIUrl":"https://doi.org/10.1007/s11427-024-2767-3","url":null,"abstract":"","PeriodicalId":21576,"journal":{"name":"Science China Life Sciences","volume":" ","pages":""},"PeriodicalIF":8.0,"publicationDate":"2024-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142792412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Population genomics advances in frontier ethnic minorities in China.
IF 8 2区 生物学
Science China Life Sciences Pub Date : 2024-12-04 DOI: 10.1007/s11427-024-2659-2
Hao Chen, Shuhua Xu
{"title":"Population genomics advances in frontier ethnic minorities in China.","authors":"Hao Chen, Shuhua Xu","doi":"10.1007/s11427-024-2659-2","DOIUrl":"https://doi.org/10.1007/s11427-024-2659-2","url":null,"abstract":"<p><p>China, with its large geographic span, possesses rich genetic diversity across vast frontier regions in addition to the Han Chinese majority. Importantly, demographic events and various natural and cultural environments in Chinese frontier regions have shaped the genomic diversity of ethnic minorities via local adaptations. Thus, insights into the genetic diversity and adaptive evolution of these under-represented ethnic groups are crucial for understanding evolutionary scenarios and biomedical implications in East Asian populations. Here, we focus on ethnic minorities in Chinese frontier regions and review research advances regarding genomic diversity, genetic structure, population history, genetic admixture, and local adaptation. We first provide an overview of the extensive genetic diversity across populations in different Chinese frontier regions. Next, we summarize research progress regarding genetic ancestry, demographic history, the adaptive process, and the archaic identification of multiple ethnic minorities in different Chinese frontier regions. Finally, we discuss the gaps and opportunities in genomic studies of Chinese populations and the need for a more comprehensive understanding of genomic diversity and the evolution of populations of East Asian ancestry in the post-genomic era.</p>","PeriodicalId":21576,"journal":{"name":"Science China Life Sciences","volume":" ","pages":""},"PeriodicalIF":8.0,"publicationDate":"2024-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142792414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Autoinhibition and cofactors of a helper NLR.
IF 8 2区 生物学
Science China Life Sciences Pub Date : 2024-12-04 DOI: 10.1007/s11427-024-2708-0
Hongyuan Zheng, Xuemin Zhou, Chenyu Zhao, Daowen Wang, Zhengqing Fu
{"title":"Autoinhibition and cofactors of a helper NLR.","authors":"Hongyuan Zheng, Xuemin Zhou, Chenyu Zhao, Daowen Wang, Zhengqing Fu","doi":"10.1007/s11427-024-2708-0","DOIUrl":"https://doi.org/10.1007/s11427-024-2708-0","url":null,"abstract":"","PeriodicalId":21576,"journal":{"name":"Science China Life Sciences","volume":" ","pages":""},"PeriodicalIF":8.0,"publicationDate":"2024-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142792384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hidden allies: the role of gut microbes in carcinogen-driven cancer.
IF 8 2区 生物学
Science China Life Sciences Pub Date : 2024-12-04 DOI: 10.1007/s11427-024-2764-9
Ye Tian, Hui Wang, Hao Wu, Jingyan Zhang
{"title":"Hidden allies: the role of gut microbes in carcinogen-driven cancer.","authors":"Ye Tian, Hui Wang, Hao Wu, Jingyan Zhang","doi":"10.1007/s11427-024-2764-9","DOIUrl":"https://doi.org/10.1007/s11427-024-2764-9","url":null,"abstract":"","PeriodicalId":21576,"journal":{"name":"Science China Life Sciences","volume":" ","pages":""},"PeriodicalIF":8.0,"publicationDate":"2024-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142792316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Construction of a lightweight, bispecific human antibody based on the bovine nano knob domain.
IF 8 2区 生物学
Science China Life Sciences Pub Date : 2024-12-04 DOI: 10.1007/s11427-024-2644-3
Siling Wang, Yizhen Wang, Xiuting Chen, Wenling Jiang, Zheng Chen, Huixian Shang, Zhiyong Li, Zizheng Zheng, Ningshao Xia
{"title":"Construction of a lightweight, bispecific human antibody based on the bovine nano knob domain.","authors":"Siling Wang, Yizhen Wang, Xiuting Chen, Wenling Jiang, Zheng Chen, Huixian Shang, Zhiyong Li, Zizheng Zheng, Ningshao Xia","doi":"10.1007/s11427-024-2644-3","DOIUrl":"https://doi.org/10.1007/s11427-024-2644-3","url":null,"abstract":"","PeriodicalId":21576,"journal":{"name":"Science China Life Sciences","volume":" ","pages":""},"PeriodicalIF":8.0,"publicationDate":"2024-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142792394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Unlocking the potential: advancements and future horizons in ROR1-targeted cancer therapies. 释放潜能：ROR1 靶向癌症疗法的进展与未来展望。
IF 8 2区 生物学
Science China Life Sciences Pub Date : 2024-12-01 Epub Date: 2024-08-12 DOI: 10.1007/s11427-024-2685-9
Lin Li, Weixue Huang, Xiaomei Ren, Zhen Wang, Ke Ding, Linxiang Zhao, Jinwei Zhang
{"title":"Unlocking the potential: advancements and future horizons in ROR1-targeted cancer therapies.","authors":"Lin Li, Weixue Huang, Xiaomei Ren, Zhen Wang, Ke Ding, Linxiang Zhao, Jinwei Zhang","doi":"10.1007/s11427-024-2685-9","DOIUrl":"10.1007/s11427-024-2685-9","url":null,"abstract":"<p><p>While receptor tyrosine kinase-like orphan receptor 1 (ROR1) is typically expressed at low levels or absent in normal tissues, its expression is notably elevated in various malignant tumors and conditions, including chronic lymphocytic leukemia (CLL), breast cancer, ovarian cancer, melanoma, and lung adenocarcinoma. This distinctive feature positions ROR1 as an attractive target for tumor-specific treatments. Currently, several targeted drugs directed at ROR1 are undergoing clinical development, including monoclonal antibodies, antibody-drug conjugates (ADCs), and chimeric antigen receptor T-cell therapy (CAR-T). Additionally, there are four small molecule inhibitors designed to bind to ROR1, presenting promising avenues for the development of PROTAC degraders targeting ROR1. This review offers updated insights into ROR1's structural and functional characteristics, embryonic development implications, cell survival signaling pathways, and evolutionary targeting strategies, all of which have the potential to advance the treatment of malignant tumors.</p>","PeriodicalId":21576,"journal":{"name":"Science China Life Sciences","volume":" ","pages":"2603-2616"},"PeriodicalIF":8.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141983125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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