Science China Life Sciences最新文献

Exaptation of pectoral fins for olfaction in the spiny red gurnard (Chelidonichthys spinosus) through an ancient receptor. 刺红鳕胸鳍通过一种古老的受体产生嗅觉。

IF 8 2区生物学

Science China Life Sciences Pub Date : 2024-11-15 DOI: 10.1007/s11427-024-2746-7

Lisen Li, Deqian Fan, Chenglong Zhu, Zhuoya Liu, Wenji Huang, Peidong Xin, Huishan Yue, Mengying Li, Yufei Wang, Wenjie Xu, Jiangmin Zheng, Ye Li, Ziwei Yu, Jianzhong Ling, Qiang Qiu, Wen Wang, Chenguang Feng, Xiaojing Song, Kun Wang

引用次数: 0

Genomic analysis of modern maize inbred lines reveals diversity and selective breeding effects. 现代玉米近交系的基因组分析揭示了多样性和选择性育种效应。

IF 8 2区生物学

Science China Life Sciences Pub Date : 2024-11-15 DOI: 10.1007/s11427-024-2725-1

Kaijian Fan, Mohsin Ali, Kunhui He, Yingwei Feng, Tingxi Yu, Hao Zhang, Tai An, Weiwei Zeng, Junjie Fu, Ying Zhou, Yanfang Heng, Fei Gu, Jiankang Wang, Changling Huang, Liang Li, Huihui Li

引用次数: 0

Genome editing technology and medical applications. 基因组编辑技术和医疗应用。

IF 8 2区生物学

Science China Life Sciences Pub Date : 2024-11-14 DOI: 10.1007/s11427-024-2773-3

Liren Wang, Bin Zhou, Dali Li

引用次数: 0

Dual activation of soybean resistance against Phytophthora sojae by pectin lyase and degraded pectin oligosaccharides. 果胶裂解酶和降解果胶低聚糖双重激活大豆抗Phytophthora sojae的能力。

IF 8 2区生物学

Science China Life Sciences Pub Date : 2024-11-13 DOI: 10.1007/s11427-024-2724-5

Guangzheng Sun, Yeqiang Xia, Kuikui Li, Qinsheng Zhu, Feifei Ding, Hui Gu, Zhichao Zhang, Xinrui Li, Xuan Mi, Jun Chen, Ruoting Yao, Sicong Zhang, Haibing Ouyang, Xi Chen, Tengfei Liu, Haibin Jiang, Yao Zhao, Min Qiu, Wenwu Ye, Kaixuan Duan, Zhenchuan Ma, Suomeng Dong, Heng Yin, Yan Wang, Yuanchao Wang

{"title":"Dual activation of soybean resistance against Phytophthora sojae by pectin lyase and degraded pectin oligosaccharides.","authors":"Guangzheng Sun, Yeqiang Xia, Kuikui Li, Qinsheng Zhu, Feifei Ding, Hui Gu, Zhichao Zhang, Xinrui Li, Xuan Mi, Jun Chen, Ruoting Yao, Sicong Zhang, Haibing Ouyang, Xi Chen, Tengfei Liu, Haibin Jiang, Yao Zhao, Min Qiu, Wenwu Ye, Kaixuan Duan, Zhenchuan Ma, Suomeng Dong, Heng Yin, Yan Wang, Yuanchao Wang","doi":"10.1007/s11427-024-2724-5","DOIUrl":"https://doi.org/10.1007/s11427-024-2724-5","url":null,"abstract":"Phytophthora pathogens secrete numerous apoplastic effectors to manipulate host immunity. Herein, we identified a polysaccharide lyase 1 protein, PsPL1, which acts as an essential virulence factor of P. sojae infection in soybean. However, the overexpression of PsPL1 in P. sojae reduced infection and triggered enhanced immune responses in soybean. PsPL1 exhibited pectin lyase activity and degraded plant pectin to generate pectin oligosaccharides (POSs) with a polymerization degree of 3-14, exhibiting different levels of acetylation and methylation modifications. PsPL1 and the degraded pectin products triggered immune responses in soybean and different Solanaceous plants. The PsPL1-triggered immune responses required RSPL1, a membrane-localized leucine-rich repeat receptor-like protein, which is essential for Phytophthora resistance. Conversely, the PsPL1-degraded product-triggered immune responses depended on the membrane-localized lysin motif receptor-like kinase CERK1. This study reveals that the pectin lyase exhibits a dual immunogenic role during P. sojae infection, which activates plant resistance through different immune receptors and provides novel insights into the function of pectin lyase in host-pathogen interactions.","PeriodicalId":21576,"journal":{"name":"Science China Life Sciences","volume":" ","pages":""},"PeriodicalIF":8.0,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142644764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Selenium metabolism and selenoproteins function in brain and encephalopathy. 硒在大脑和脑病中的代谢和硒蛋白功能。

IF 8 2区生物学

Science China Life Sciences Pub Date : 2024-11-12 DOI: 10.1007/s11427-023-2621-7

Nan Li, Zhonghao Zhang, Liming Shen, Guoli Song, Jing Tian, Qiong Liu, Jiazuan Ni

{"title":"Selenium metabolism and selenoproteins function in brain and encephalopathy.","authors":"Nan Li, Zhonghao Zhang, Liming Shen, Guoli Song, Jing Tian, Qiong Liu, Jiazuan Ni","doi":"10.1007/s11427-023-2621-7","DOIUrl":"https://doi.org/10.1007/s11427-023-2621-7","url":null,"abstract":"Selenium (Se) is an essential trace element of the utmost importance to human health. Its deficiency induces various disorders. Se species can be absorbed by organisms and metabolized to hydrogen selenide for the biosynthesis of selenoproteins, selenonucleic acids, or selenosugars. Se in mammals mainly acts as selenoproteins to exert their biological functions. The brain ranks highest in the specific hierarchy of organs to maintain the level of Se and the expression of selenoproteins under the circumstances of Se deficiency. Dyshomeostasis of Se and dysregulation of selenoproteins result in encephalopathy such as Alzheimer's disease, Parkinson's disease, depression, amyotrophic lateral sclerosis, and multiple sclerosis. This review provides a summary and discussion of Se metabolism, selenoprotein function, and their roles in modulating brain diseases based on the most currently published literature. It focuses on how Se is utilized and transported to the brain, how selenoproteins are biosynthesized and function physiologically in the brain, and how selenoproteins are involved in neurodegenerative diseases. At the end of this review, the perspectives and problems are outlined regarding Se and selenoproteins in the regulation of encephalopathy.","PeriodicalId":21576,"journal":{"name":"Science China Life Sciences","volume":" ","pages":""},"PeriodicalIF":8.0,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142639701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

rAAV-CRISPR/Cas9-mediated in vivo delivery of porcine embryos to construct knockout pigs. rAAV-CRISPR/Cas9 介导的猪胚胎体内传递，构建基因敲除猪。

IF 8 2区生物学

Science China Life Sciences Pub Date : 2024-11-11 DOI: 10.1007/s11427-024-2749-8

Mengyu Gao, YuTing He, XingLong Zhu, WanLiu Peng, Xinmei Liu, Yanyan Zhou, Yang Deng, Qin Liu, Guangneng Liao, Yi Li, Wei Ni, Guang Yang, Jiayin Yang, Yang Yang, Lang Bai, Hong Bu, Ji Bao

引用次数: 0

Research landmarks on the 60th anniversary of Epstein-Barr virus. Epstein-Barr 病毒 60 周年研究里程碑。

IF 8 2区生物学

Science China Life Sciences Pub Date : 2024-11-04 DOI: 10.1007/s11427-024-2766-0

Lan-Yi Zhong, Chu Xie, Le-Le Zhang, Yan-Lin Yang, Yuan-Tao Liu, Ge-Xin Zhao, Guo-Long Bu, Xian-Shu Tian, Zi-Ying Jiang, Bo-Yu Yuan, Peng-Lin Li, Pei-Huang Wu, Wei-Hua Jia, Christian Münz, Benjamin E Gewurz, Qian Zhong, Cong Sun, Mu-Sheng Zeng

引用次数: 0

COVID-19 vaccine updates for people under different conditions. 针对不同人群的 COVID-19 疫苗更新。

IF 8 2区生物学

Science China Life Sciences Pub Date : 2024-11-01 Epub Date: 2024-07-29 DOI: 10.1007/s11427-024-2643-1

Yijiao Huang, Weiyang Wang, Yan Liu, Zai Wang, Bin Cao

{"title":"COVID-19 vaccine updates for people under different conditions.","authors":"Yijiao Huang, Weiyang Wang, Yan Liu, Zai Wang, Bin Cao","doi":"10.1007/s11427-024-2643-1","DOIUrl":"10.1007/s11427-024-2643-1","url":null,"abstract":"SARS-CoV-2 has caused global waves of infection since December 2019 and continues to persist today. The emergence of SARS-CoV-2 variants with strong immune evasion capabilities has compromised the effectiveness of existing vaccines against breakthrough infections. Therefore, it is important to determine the best utilization strategies for different demographic groups given the variety of vaccine options available. In this review, we will discuss the protective efficacy of vaccines during different stages of the epidemic and emphasize the importance of timely updates to target prevalent variants, which can significantly improve immune protection. While it is recognized that vaccine effectiveness may be lower in certain populations such as the elderly, individuals with chronic comorbidities (e.g., diabetes with poor blood glucose control, those on maintenance dialysis), or those who are immunocompromised compared to the general population, administering multiple doses can result in a strong protective immune response that outweighs potential risks. However, caution should be exercised when considering vaccines that might trigger an intense immune response in populations prone to inflammatory flare or other complications. In conclusion, individuals with special conditions require enhanced and more effective immunization strategies to prevent infection or reinfection, as well as to avoid the potential development of long COVID.","PeriodicalId":21576,"journal":{"name":"Science China Life Sciences","volume":" ","pages":"2323-2343"},"PeriodicalIF":8.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141856426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Innovative genome editing in plants: a transposase and CRISPR combination approach. 创新的植物基因组编辑：转座酶和 CRISPR 组合方法。

IF 8 2区生物学

Science China Life Sciences Pub Date : 2024-11-01 DOI: 10.1007/s11427-024-2729-2

Hamza Sohail, Iqra Noor, Xuehao Chen, Xiaodong Yang

引用次数: 0

A CRISPR/RfxCas13d-mediated strategy for efficient RNA knockdown in mouse embryonic development. CRISPR/RfxCas13d 介导的小鼠胚胎发育中高效 RNA 敲除策略。

IF 8 2区生物学

Science China Life Sciences Pub Date : 2024-11-01 Epub Date: 2024-08-02 DOI: 10.1007/s11427-023-2572-6

Lin Zhang, Shi-Meng Cao, Hao Wu, Meng Yan, Jinsong Li, Ling-Ling Chen

引用次数: 0