Science China Life Sciences最新文献

{"title":"Profile of Dr. Hang Sun.","authors":"","doi":"10.1007/s11427-024-2815-2","DOIUrl":"https://doi.org/10.1007/s11427-024-2815-2","url":null,"abstract":"","PeriodicalId":21576,"journal":{"name":"Science China Life Sciences","volume":" ","pages":""},"PeriodicalIF":8.0,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143441804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Profile of Dr. Shaorong Gao.","authors":"","doi":"10.1007/s11427-024-2689-5","DOIUrl":"https://doi.org/10.1007/s11427-024-2689-5","url":null,"abstract":"","PeriodicalId":21576,"journal":{"name":"Science China Life Sciences","volume":" ","pages":""},"PeriodicalIF":8.0,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143441807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Toll-like receptor signaling in teleosts.","authors":"Jianguo Su","doi":"10.1007/s11427-024-2822-5","DOIUrl":"https://doi.org/10.1007/s11427-024-2822-5","url":null,"abstract":"<p><p>Toll-like receptors (TLRs) sit at the top of the immune system pyramid. They form a paramount family of immune sentinels capable of sensing diverse microbe-associated molecular patterns (MAPMs), danger/damage-associated molecular patterns (DAMPs), and other signals. These perceptions trigger immediate innate immunity and instruct subsequent adaptive immunity. TLRs are highly glycosylated type I transmembrane glycoproteins that share a conserved tripartite domain architecture (LRR, TM and TIR domains), classified into six subfamilies (TLR1, TLR3, TLR4, TLR5, TLR7, TLR11) in vertebrates. Upon ligand engagement, TLRs form homodimers or heterodimers to activate immune responses via SMOCs, orchestrated by intrinsic and pathogen-directed negative regulators, glycosylation modification, etc. TLR signaling culminates in the production of inflammatory cytokines, interferons, inflammasomes, immune cell activation, apoptosis, etc. Teleosts, as the largest and most diverse group among the extant vertebrates, manifest important economic value and are crucial for understanding the evolution of vertebrate immunity. To date, teleosts contain 20 TLRs (TLR1-5, TLR7-9, TLR13, TLR14, TLR18-23, TLR25-28) with expansions and losses in different species, and most of them possess more or less variants. Almost all teleostean TLRs localize in organelles, such as endosomes and lysosomes, sensing not only pathogens and DAMPs but also trophic factors and environmental stresses (hypoxia, temperature, microplastics, etc.). Most ligands for TLRs remain undetermined in teleosts. The adaptors consist of MyD88, TIRAP, TRIF, SARM1, BCAP and SCIMP, but without TRAM; however, half of the corresponding relationships between TLRs and adaptors remain unknown in teleosts. Neofunctionalization often emerges during evolution in teleostean TLRs. Here, a systematic review of TLR signaling in teleosts, from the perspective of comparative immunology, presents the current understanding of the functions and mechanisms of teleosts. Additionally, it provides strong evidence of a divergent TLR signaling repertoire with the species-specific variation among teleosts. These are expected to benefit novel adjuvants, aquaculture, fish immunology, and comparative immunology.</p>","PeriodicalId":21576,"journal":{"name":"Science China Life Sciences","volume":" ","pages":""},"PeriodicalIF":8.0,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143441810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Understanding CoQ evolution in plants for crop trait design.","authors":"Ya-Long Guo","doi":"10.1007/s11427-025-2867-2","DOIUrl":"https://doi.org/10.1007/s11427-025-2867-2","url":null,"abstract":"","PeriodicalId":21576,"journal":{"name":"Science China Life Sciences","volume":" ","pages":""},"PeriodicalIF":8.0,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143441829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lentiviral vectors for gene therapy of α-thalassemia.","authors":"Saijuan Xu, Dan Liang, Yan Cheng, Gongrui Sun, Feiyan Zhao, Yang Yang, Haokun Zhang, Yongrong Lai, Bin Fu, Yuxuan Wu","doi":"10.1007/s11427-024-2820-9","DOIUrl":"https://doi.org/10.1007/s11427-024-2820-9","url":null,"abstract":"","PeriodicalId":21576,"journal":{"name":"Science China Life Sciences","volume":" ","pages":""},"PeriodicalIF":8.0,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143441796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficient generation of all ESC-derived mice carrying a homozygous lethal mutation through eight-cell embryo injection.","authors":"Xidi Yin, Meng Yan, Yanbo Cheng, Zhoujie Li, Chong Cui, Yingyi Wang, Nan Liu, Yilai Shu, Jinsong Li, Qing Li","doi":"10.1007/s11427-024-2762-3","DOIUrl":"https://doi.org/10.1007/s11427-024-2762-3","url":null,"abstract":"","PeriodicalId":21576,"journal":{"name":"Science China Life Sciences","volume":" ","pages":""},"PeriodicalIF":8.0,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143441734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integration of CRISPR screening and proteomic analysis of WDR91 manipulation of endosome-to-cytosol transport of African swine fever virus.","authors":"Hailong Liu, Yilin Guo, Zishi Guo, Limeng Sun, Dagang Tao, Xinyun Li, Guiqing Peng, Shuhong Zhao, Shengsong Xie","doi":"10.1007/s11427-024-2739-9","DOIUrl":"https://doi.org/10.1007/s11427-024-2739-9","url":null,"abstract":"","PeriodicalId":21576,"journal":{"name":"Science China Life Sciences","volume":" ","pages":""},"PeriodicalIF":8.0,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143441760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Potential oligonucleotide drugs in Bencao sRNA Atlas (II).","authors":"Chengyu Jiang","doi":"10.1007/s11427-024-2802-2","DOIUrl":"https://doi.org/10.1007/s11427-024-2802-2","url":null,"abstract":"","PeriodicalId":21576,"journal":{"name":"Science China Life Sciences","volume":" ","pages":""},"PeriodicalIF":8.0,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143441800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treating incurable non-communicable diseases by targeting iron metabolism and ferroptosis.","authors":"Ruoxuan Ni, Jianwei Jiang, Fudi Wang, Junxia Min","doi":"10.1007/s11427-024-2787-y","DOIUrl":"https://doi.org/10.1007/s11427-024-2787-y","url":null,"abstract":"<p><p>Both iron metabolism and ferroptosis (an iron-dependent form of programmed cell death) have been connected to the development and progression of many currently incurable non-communicable diseases, including Alzheimer's disease, Parkinson's disease, multiple sclerosis, Huntington's disease, metabolic dysfunction-associated steatohepatitis, heart failure, and both treatment-relapsed and refractory cancers, such as pancreatic ductal adenocarcinoma and triple-negative breast cancer. Thus, understanding the relationship between iron and these diseases can pave the way for the development of novel therapeutic strategies. Here, we summarize the latest evidence supporting the pathological roles of dysregulated iron metabolism and ferroptosis in a wide range of preclinical animal models of these currently incurable non-communicable diseases. We also summarize the feasibility of targeting iron metabolism and ferroptosis for the prevention and treatment of iron- and ferroptosis-related diseases that currently have limited treatment options. In addition, we provide our perspectives on the challenges and promises regarding the translational potential of targeting dysregulated iron metabolism and ferroptosis to treat diseases, highlighting the future roadmap for developing iron- and ferroptosis-targeted therapeutics.</p>","PeriodicalId":21576,"journal":{"name":"Science China Life Sciences","volume":" ","pages":""},"PeriodicalIF":8.0,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143441817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exaptation of pectoral fins for olfaction in the spiny red gurnard (Chelidonichthys spinosus) through an ancient receptor.","authors":"Lisen Li, Deqian Fan, Chenglong Zhu, Zhuoya Liu, Wenji Huang, Peidong Xin, Huishan Yue, Mengying Li, Yufei Wang, Wenjie Xu, Jiangmin Zheng, Ye Li, Ziwei Yu, Jianzhong Ling, Qiang Qiu, Wen Wang, Chenguang Feng, Xiaojing Song, Kun Wang","doi":"10.1007/s11427-024-2746-7","DOIUrl":"10.1007/s11427-024-2746-7","url":null,"abstract":"","PeriodicalId":21576,"journal":{"name":"Science China Life Sciences","volume":" ","pages":"582-585"},"PeriodicalIF":8.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142668982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}