Science China Life Sciences最新文献

N⁶-methyladenosine reader YTHDF3-mediated CEBPA translation maintains genomic stability and stem cell function to prevent liver injury. n6 -甲基腺苷读取器ythdf3介导的CEBPA翻译维持基因组稳定性和干细胞功能，以防止肝损伤。

IF 9.5 2区生物学

Science China Life Sciences Pub Date : 2025-08-01 Epub Date: 2025-05-30 DOI: 10.1007/s11427-024-2793-x

Yaxu Liang, Weiwei Yu, Haifeng Sun, Dayu Wang, Zhibo Wang, Hailing Shi, Yang Cao, Zijie Zhang, Jun Liu, Zhongyu Zou, Jiangbo Wei, Tong Wu, Dongming Yu, Jun Qi, Jiamin Wu, Bryan C Dickinson, Pingping Zhu, Bin Shen, Beicheng Sun, Chuan He, Xiang Zhong

{"title":"N6-methyladenosine reader YTHDF3-mediated CEBPA translation maintains genomic stability and stem cell function to prevent liver injury.","authors":"Yaxu Liang, Weiwei Yu, Haifeng Sun, Dayu Wang, Zhibo Wang, Hailing Shi, Yang Cao, Zijie Zhang, Jun Liu, Zhongyu Zou, Jiangbo Wei, Tong Wu, Dongming Yu, Jun Qi, Jiamin Wu, Bryan C Dickinson, Pingping Zhu, Bin Shen, Beicheng Sun, Chuan He, Xiang Zhong","doi":"10.1007/s11427-024-2793-x","DOIUrl":"10.1007/s11427-024-2793-x","url":null,"abstract":"Liver injury is a major health issue with significant implications for liver function and overall well-being, but precise mechanisms of the N6-methyladenine (m6A) reader YTHDF3 in liver injury remain severely understudied. Here, we discovered that Ythdf3 knockout exacerbated CCL4-induced liver injury with a reduction in functional hepatocytes and liver stem cells using single cell RNA-sequencing and organoid culture. Furthermore, Mettl14 and YTHDF3-dependent RNA m6A dysregulation induced DNA damage. Moreover, we found YTHDF3 could bind and modulate CCAAT/enhancer-binding protein-alpha (CEBPA) translation in an m6A-dependent manner. Mechanistically, knockout of Ythdf3 impeded the translation of CEBPA, subsequently inhibiting the expression of poly(ADP-ribose) (PAR) polymerase-1 (PARP1) and Peroxiredoxin 2 (PRDX2). This inhibition promoted DNA damage and genomic instability, ultimately exacerbating liver damage. This work uncovers an essential role of m6A/YTHDF3/CEBPA regulatory axes in governing cell fates and genomic stability, thereby preventing liver injury. Importantly, these findings offer potential therapeutic avenues for targeting YTHDF3 and CEBPA in the treatment of liver injury-related diseases.","PeriodicalId":21576,"journal":{"name":"Science China Life Sciences","volume":" ","pages":"2456-2471"},"PeriodicalIF":9.5,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144249451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evolution of sexual dimorphism in nonhuman primates. 非人灵长类动物两性异形的进化。

IF 9.5 2区生物学

Science China Life Sciences Pub Date : 2025-08-01 Epub Date: 2025-03-17 DOI: 10.1007/s11427-024-2796-3

Yuan-Ting Guo, Yijun Yang, Bolun Zhang, Hao Wu, Lei Wang, Baoguo Li, Christopher Opie, Xiao-Guang Qi

引用次数: 0

Genetic mutations across multiple pathways drive filamentous growth and virulence in the emerging fungal pathogen Candida auris. 多种途径的基因突变推动了新出现的真菌病原体白色念珠菌的丝状生长和毒力。

IF 9.5 2区生物学

Science China Life Sciences Pub Date : 2025-08-01 Epub Date: 2025-04-03 DOI: 10.1007/s11427-024-2902-9

Chao Li, Shuaihu Li, Qiushi Zheng, Li Tao, Jian Bing, Zhangyue Guan, Tianren Hu, Haiqing Chu, Guanghua Huang

引用次数: 0

Transcription factor addictions: exploring the potential Achilles' Heel of endometriosis. 转录因子成瘾：探索子宫内膜异位症的潜在致命弱点。

IF 9.5 2区生物学

Science China Life Sciences Pub Date : 2025-08-01 Epub Date: 2025-03-27 DOI: 10.1007/s11427-024-2832-8

Yang Yang, Yi Du, Xuelei Ma, Gang Yuan, Guobo Li, Qian Zhang, Shengtao Zhou

引用次数: 0

Molecular genetics of congenital heart disease. 先天性心脏病的分子遗传学。

IF 9.5 2区生物学

Science China Life Sciences Pub Date : 2025-08-01 Epub Date: 2025-03-27 DOI: 10.1007/s11427-024-2861-9

Xiaoqing Zhang, Ming Qi, Qihua Fu

引用次数: 0

Genomic and chromosomal architectures underlying fertility maintenance in the testes of intergeneric homoploid hybrids. 属间同倍体杂交种睾丸维持生育能力的基因组和染色体结构。

IF 9.5 2区生物学

Science China Life Sciences Pub Date : 2025-08-01 Epub Date: 2025-05-23 DOI: 10.1007/s11427-024-2868-y

Li Ren, Yiyan Zeng, Qizhi Liu, Xiaolong Tu, Fayi Chen, Hao Wu, Chuan Wang, Chang Wu, Mengxue Luo, Yakui Tai, Hailu Zhou, Mengdan Li, Ling Liu, Dongdong Wu, Shaojun Liu

{"title":"Genomic and chromosomal architectures underlying fertility maintenance in the testes of intergeneric homoploid hybrids.","authors":"Li Ren, Yiyan Zeng, Qizhi Liu, Xiaolong Tu, Fayi Chen, Hao Wu, Chuan Wang, Chang Wu, Mengxue Luo, Yakui Tai, Hailu Zhou, Mengdan Li, Ling Liu, Dongdong Wu, Shaojun Liu","doi":"10.1007/s11427-024-2868-y","DOIUrl":"10.1007/s11427-024-2868-y","url":null,"abstract":"The remarkable diversity of the Cyprinidae family highlights the importance of hybridization and gene flow in generating genetic variation, adaptation, and even speciation. However, why do cyprinid fish frequently overcome postzygotic reproductive isolation, a mechanism that normally prevents successful reproduction after fertilization? To address this gap in knowledge, we conducted comparative studies using reciprocal F1 hybrid lineages derived from intergeneric hybridization between the cyprinid species Megalobrama amblycephala and Culter alburnus. Utilizing long-read genome sequencing, ATAC-seq, Hi-C, and mRNA-seq technologies, we identified rapid genomic variations, chromatin remodeling, and gene expression changes in the testicular cells of F1 hybrid individuals. By analyzing the distribution of these alterations across three gene categories (allelic genes, orphan genes, and testis-specific genes), we found that changes were less pronounced in allelic and testis-specific genes but significantly more pronounced in orphan genes. Furthermore, we hypothesize that rnf212b is a crucial testis-specific gene that regulates spermatogenesis. Our findings suggest that allelic and testis-specific genes potentially mitigate \"genomic shock\" on reproductive function following hybridization. This research offers potential insights into the formation mechanisms of homoploid hybridization by demonstrating the coordinated interplay of genomic variations, chromatin remodeling, and gene expression changes during testicular development and spermatogenesis.","PeriodicalId":21576,"journal":{"name":"Science China Life Sciences","volume":" ","pages":"2379-2392"},"PeriodicalIF":9.5,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144161929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

CCR5-mediated dynamic maintenance of resident memory T cells in the respiratory tract. ccr5介导的呼吸道常驻记忆T细胞的动态维持。

IF 9.5 2区生物学

Science China Life Sciences Pub Date : 2025-08-01 Epub Date: 2025-05-30 DOI: 10.1007/s11427-024-2920-y

Tiange Shao, Jiacheng Yao, Shiyue Hou, Jianbin Wang, Hai Qi

{"title":"CCR5-mediated dynamic maintenance of resident memory T cells in the respiratory tract.","authors":"Tiange Shao, Jiacheng Yao, Shiyue Hou, Jianbin Wang, Hai Qi","doi":"10.1007/s11427-024-2920-y","DOIUrl":"10.1007/s11427-024-2920-y","url":null,"abstract":"Tissue-resident memory T cells (TRM) play a key role in defense against pathogen invading barrier sites and other non-lymphoid tissues. How TRM cells are maintained in various tissues, and how they relate to antigen-experienced memory T cells in lymphoid organs are not fully understood. By barcode-based lineage tracing and single-cell transcriptome analysis, we found a distinct population of CD69+CD103+ virus-specific CD8+ T cells in draining lymph nodes (dLNs) following intranasal influenza infection. Intriguingly, these dLN TRM cells and lung TRM cells shared similar function-neutral barcode contents and transcriptomic features, implicating local circulation between the lung and dLNs in the maintenance of resident memory. Ablation of CXCR3 from CD8+ T cells, which impairs lung TRM generation, severely reduced the abundance of dLN TRM cells, suggesting that dLN TRM cells are connected to lung TRM cells by retrograde migration. Our screen for chemokines and chemokine receptors implicated the CCR5-CCL5 axis in promoting lung-to-dLN migration. Temporary CCR5 blockade by intratracheal administration of Maraviroc, a CCR5 inhibitor, reduced the abundance of dLN TRM cells without affecting lung TRM cells. By intratracheal cell transfer, CCR5-deficient CD8+ T cells were found impaired in lung-to-dLN migration. Finally, dLN TRM cells actively participated in the secondary response and could reconstitute lung TRM cells following influenza infection. Our results support a model in which lung-to-dLN TRM retrograde migration helps maintain the CD8+ memory resident in the respiratory tract and optimizes the local T-cell response to reinfection.","PeriodicalId":21576,"journal":{"name":"Science China Life Sciences","volume":" ","pages":"2431-2441"},"PeriodicalIF":9.5,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144209319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

PanSci: decoding panoramas of ageing. 潘sci：解码衰老全景图。

IF 9.5 2区生物学

Science China Life Sciences Pub Date : 2025-08-01 Epub Date: 2025-04-23 DOI: 10.1007/s11427-025-2927-8

Yalan Liao, Mingguo Qiu, Yan-Jiang Wang

引用次数: 0

Rice genetic variations provide information on the potential to reduce thiamin deficiencies. 水稻遗传变异提供了减少维生素缺乏症的可能性的信息。

IF 9.5 2区生物学

Science China Life Sciences Pub Date : 2025-08-01 Epub Date: 2025-04-23 DOI: 10.1007/s11427-025-2926-x

Teresa B Fitzpatrick, Simon Strobbe, Maria Faustino

引用次数: 0

Decoding tardigrade extreme stress tolerance. 解码缓步动物的极端耐受力。