Science China Life Sciences最新文献

Evolution of sexual dimorphism in nonhuman primates.

IF 8 2区生物学

Science China Life Sciences Pub Date : 2025-03-17 DOI: 10.1007/s11427-024-2796-3

Yuan-Ting Guo, Yijun Yang, Bolun Zhang, Hao Wu, Lei Wang, Baoguo Li, Christopher Opie, Xiao-Guang Qi

引用次数: 0

Genomic insights into the brooding reproduction and climate-driven dynamics of Pocillopora damicornis in the Anthropocene.

IF 8 2区生物学

Science China Life Sciences Pub Date : 2025-03-17 DOI: 10.1007/s11427-024-2821-0

Jie Li, Yali Liu, Zhixin Zhang, Yu Chen, Jian Zhang, Haiyan Yu, Yingyi Zhang, Cong Liu, Zhuang Shao, David G Bourne, Meng Qu, Si Zhang, Qiang Lin

引用次数: 0

The immuno-metabolic trade-off: a driver of metabolic disorders and aging.

IF 8 2区生物学

Science China Life Sciences Pub Date : 2025-03-17 DOI: 10.1007/s11427-024-2881-8

Juanhong Liu, Qinlei Huang, Feng Liu

引用次数: 0

Biomedical data and AI.

IF 8 2区生物学

Science China Life Sciences Pub Date : 2025-03-14 DOI: 10.1007/s11427-024-2859-1

Hao Xu, Shibo Zhou, Zefeng Zhu, Vincenzo Vitelli, Liangyi Chen, Ziwei Dai, Ning Yang, Luhua Lai, Shengyong Yang, Sergey Ovchinnikov, Zhuoran Qiao, Sirui Liu, Chen Song, Jianfeng Pei, Han Wen, Jianfeng Feng, Yaoyao Zhang, Zhengwei Xie, Yang-Yu Liu, Zhiyuan Li, Fulai Jin, Hao Li, Mohammad Lotfollahi, Xuegong Zhang, Ge Yang, Shihua Zhang, Ge Gao, Pulin Li, Qi Liu, Jing-Dong Jackie Han

引用次数: 0

A tango between NSUN2 and TET2: defining both the fate and origin of RNA.

IF 8 2区生物学

Science China Life Sciences Pub Date : 2025-03-12 DOI: 10.1007/s11427-024-2862-x

Tianbao Shang, Lu Liu, Zitan Li, Yichi Xu, Yujiang Geno Shi, Li Tan

引用次数: 0

Vibration mechanics involved in buzz pollination lead to size-dependent associations between bumblebees and Pedicularis flowers.

IF 8 2区生物学

Science China Life Sciences Pub Date : 2025-03-12 DOI: 10.1007/s11427-024-2858-5

Yuanqing Xu, Bentao Wu, Mario Vallejo-Marín, Peter Bernhardt, Mark Jankauski, De-Zhu Li, Stephen Buchmann, Jianing Wu, Hong Wang

{"title":"Vibration mechanics involved in buzz pollination lead to size-dependent associations between bumblebees and Pedicularis flowers.","authors":"Yuanqing Xu, Bentao Wu, Mario Vallejo-Marín, Peter Bernhardt, Mark Jankauski, De-Zhu Li, Stephen Buchmann, Jianing Wu, Hong Wang","doi":"10.1007/s11427-024-2858-5","DOIUrl":"https://doi.org/10.1007/s11427-024-2858-5","url":null,"abstract":"Floral traits modify pollinator behavior and shape the plant-pollinator interaction pattern at ecological and evolutionary levels. Biomechanical traits are important in mediating interactions between flowers and their pollinators in some cases, such as in buzz pollination. During buzz pollination, a bee produces vibrations using its thoracic muscles and transfers these vibrations primarily through its mandibles as it bites the flower. The interaction between buzz-pollinated flowers and their pollinators is influenced by their physical size relative to each other, but the drivers of these size-dependent associations remain unclear. Using eight beaked louseworts (Pedicularis) as a model system, we combined behavioral observations, biomechanical analyses, and pollinator network analyses to test the hypothesis that the location of where a bee bites should constrain the interaction between Pedicularis and bumblebees during buzz pollination. We found that bumblebees always chose to bite the same site at the base of the floral beak when buzzing Pedicularis, and this site is optimal for transferring vibrations from the bee to release pollen from the anthers. Bee bodies must be long enough for the mandibles to clamp onto the same optimal site on the floral beak, while its pollen-collecting abdomen is positioned at the opening of the floral beak where pollen grains are ejected. Our pollination networks showed size matching between the floral beak length of each Pedicularis species and the body length of individual bumblebees regardless of bee species. These results suggest that the optimal excitation point on the Pedicularis flower links a suite of floral traits to its pollinators' dimensions, potentially contributing to prezygotic isolation among co-flowering, sympatric Pedicularis species.","PeriodicalId":21576,"journal":{"name":"Science China Life Sciences","volume":" ","pages":""},"PeriodicalIF":8.0,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143650062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Low-dose lactate promotes neuroinflammation and induces the side effect of colitis.

IF 8 2区生物学

Science China Life Sciences Pub Date : 2025-03-12 DOI: 10.1007/s11427-024-2879-6

Weiyan Wang, Mengdi Guo, Chuyu Wu, Bin Huang, Mei-Ling Jiang, Cun-Jin Zhang

引用次数: 0

Dynamic WNT signaling controls differentiation of hematopoietic progenitor cells from human pluripotent stem cells.

IF 8 2区生物学

Science China Life Sciences Pub Date : 2025-03-11 DOI: 10.1007/s11427-024-2816-0

Mo Li, Keiichiro Suzuki, Mengge Wang, Christopher Benner, Manching Ku, Li Ma, Ladan Kobari, Na Young Kim, Nuria Montserrat, Chan-Jung Chang, Guanghui Liu, Jing Qu, Jinna Xu, Yingzi Zhang, Emi Aizawa, Jun Wu, Luc Douay, Concepcion Rodriguez Esteban, Juan Carlos Izpisua Belmonte

{"title":"Dynamic WNT signaling controls differentiation of hematopoietic progenitor cells from human pluripotent stem cells.","authors":"Mo Li, Keiichiro Suzuki, Mengge Wang, Christopher Benner, Manching Ku, Li Ma, Ladan Kobari, Na Young Kim, Nuria Montserrat, Chan-Jung Chang, Guanghui Liu, Jing Qu, Jinna Xu, Yingzi Zhang, Emi Aizawa, Jun Wu, Luc Douay, Concepcion Rodriguez Esteban, Juan Carlos Izpisua Belmonte","doi":"10.1007/s11427-024-2816-0","DOIUrl":"https://doi.org/10.1007/s11427-024-2816-0","url":null,"abstract":"Human pluripotent stem cells (hPSCs) can in theory give rise to any hematopoietic lineages, thereby offering opportunities for disease modeling, drug screening and cell therapies. However, gaps in our knowledge of the signaling requirements for the specification of human hematopoietic stem/progenitor cells (HSPCs), which lie at the apex of all hematopoietic lineages, greatly limit the potential of hPSC in hematological research and application. Transcriptomic analysis reveals aberrant regulation of WNT signaling during maturation of hPSC-derived hematopoietic progenitor cells (hPSC-HPCs), which results in higher mitochondria activity, misregulation of HOX genes, loss of self-renewal and precocious differentiation. These defects are partly due to the activation of the WNT target gene CDX2. Late-stage WNT inhibition improves the yield, self-renewal, multilineage differentiation, and transcriptional and metabolic profiles of hPSC-HPCs. Genome-wide mapping of transcription factor (TF) accessible chromatin reveals a significant overrepresentation of myeloid TF binding motifs in hPSC-HPCs, which could underlie their myeloid-biased lineage potential. Together our findings uncover a previously unappreciated dynamic requirement of the WNT signaling pathway during the specification of human HSPCs. Modulating the WNT pathway with small molecules normalizes the molecular differences between hPSC-HPCs and endogenous hematopoietic stem cells (HSCs), thereby representing a promising approach to improve the differentiation and function of hPSC-HPCs.","PeriodicalId":21576,"journal":{"name":"Science China Life Sciences","volume":" ","pages":""},"PeriodicalIF":8.0,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143625862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Root exudates and microbial metabolites: signals and nutrients in plant-microbe interactions.

IF 8 2区生物学

Science China Life Sciences Pub Date : 2025-03-11 DOI: 10.1007/s11427-024-2876-0

Xiaoyan Fan, An-Hui Ge, Shanshan Qi, Yuefeng Guan, Ran Wang, Nan Yu, Ertao Wang

{"title":"Root exudates and microbial metabolites: signals and nutrients in plant-microbe interactions.","authors":"Xiaoyan Fan, An-Hui Ge, Shanshan Qi, Yuefeng Guan, Ran Wang, Nan Yu, Ertao Wang","doi":"10.1007/s11427-024-2876-0","DOIUrl":"https://doi.org/10.1007/s11427-024-2876-0","url":null,"abstract":"Plant roots meticulously select and attract particular microbial taxa from the surrounding bulk soil, thereby establishing a specialized and functionally diverse microbial community within the rhizosphere. Rhizosphere metabolites, including root exudates and microbial metabolites, function as both signals and nutrients that govern the assembly of the rhizosphere microbiome, playing crucial roles in mediating communications between plants and microbes. The environment and their feedback loops further influence these intricate interactions. However, whether and how specific metabolites shape plant-microbe interactions and facilitate diverse functions remains obscure. This review summarizes the current progress in plant-microbe communications mediated by chemical compounds and their functions in plant fitness and ecosystem functioning. Additionally, we raise some prospects on future directions for manipulating metabolite-mediated plant-microbe interactions to enhance crop productivity and health. Unveiling the biological roles of specific metabolites produced by plants and microbes will bridge the gap between fundamental research and practical applications.","PeriodicalId":21576,"journal":{"name":"Science China Life Sciences","volume":" ","pages":""},"PeriodicalIF":8.0,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143625864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A novel deacetylase inhibitor KLX suppresses liver fibrosis by deacetylating PPARγ through promoting ubiquitination-mediated HDAC1 degradation.

IF 8 2区生物学

Science China Life Sciences Pub Date : 2025-03-07 DOI: 10.1007/s11427-024-2827-y

Feng Zhang, Jinglun Song, Han Wu, Keying Lin, Chunlei Wang, Linghua Zeng, Xue Kong, Kunkun Zou, Hongtao Diao, Zhuo Wang, Wei Si, Weitao Jiang, Yang Yang, Fangting Yao, Xinyue Zhang, Yuting Xiong, Qiaoyue Zhao, Tianqi Duo, Jiaming Ju, Tengfei Pan, Baofeng Yang, Yu Bian

{"title":"A novel deacetylase inhibitor KLX suppresses liver fibrosis by deacetylating PPARγ through promoting ubiquitination-mediated HDAC1 degradation.","authors":"Feng Zhang, Jinglun Song, Han Wu, Keying Lin, Chunlei Wang, Linghua Zeng, Xue Kong, Kunkun Zou, Hongtao Diao, Zhuo Wang, Wei Si, Weitao Jiang, Yang Yang, Fangting Yao, Xinyue Zhang, Yuting Xiong, Qiaoyue Zhao, Tianqi Duo, Jiaming Ju, Tengfei Pan, Baofeng Yang, Yu Bian","doi":"10.1007/s11427-024-2827-y","DOIUrl":"https://doi.org/10.1007/s11427-024-2827-y","url":null,"abstract":"Liver fibrosis is a pathological response following liver injury induced by various etiologies. Herein, we present the therapeutic potential of a novel anthraquinone compound, kanglexin (KLX), in the treatment of liver fibrosis. We observed significant suppression of the inflammatory response and extracellular matrix deposition in mice with liver fibrosis induced by CCL4, by bile duct ligation, and by a methionine-choline-deficient diet. Mechanistically, through screening, we found that KLX interacts with HDAC1. Additionally, KLX facilitates binding between HDAC1 and KCTD11, promoting the ubiquitination-mediated degradation of HDAC1 and consequently reducing its protein level. Moreover, HDAC1 was found to bind to PPARγ, influencing its acetylation level. Following KLX treatment, the level of PPARγ deacetylation mediated by HDAC1 decreases, leading to increased protein expression of PPARγ. This effectively inhibited the NFκB and TGF-β/Smad2/3 signaling pathways, thereby reducing inflammation and extracellular matrix deposition. Ultimately, this intervention can halt the progression of liver fibrosis and ameliorate liver damage. In summary, our study demonstrated that KLX can effectively inhibit the progression of liver fibrosis by modulating the protein level and activity of HDAC1. These findings provide valuable insights for the development of effective drugs and treatment strategies for liver fibrosis.","PeriodicalId":21576,"journal":{"name":"Science China Life Sciences","volume":" ","pages":""},"PeriodicalIF":8.0,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143586679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0