Science China Life Sciences最新文献

{"title":"Integration of CRISPR screening and proteomic analysis of WDR91 manipulation of endosome-to-cytosol transport of African swine fever virus.","authors":"Hailong Liu, Yilin Guo, Zishi Guo, Limeng Sun, Dagang Tao, Xinyun Li, Guiqing Peng, Shuhong Zhao, Shengsong Xie","doi":"10.1007/s11427-024-2739-9","DOIUrl":"https://doi.org/10.1007/s11427-024-2739-9","url":null,"abstract":"","PeriodicalId":21576,"journal":{"name":"Science China Life Sciences","volume":" ","pages":""},"PeriodicalIF":8.0,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143441760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Potential oligonucleotide drugs in Bencao sRNA Atlas (II).","authors":"Chengyu Jiang","doi":"10.1007/s11427-024-2802-2","DOIUrl":"https://doi.org/10.1007/s11427-024-2802-2","url":null,"abstract":"","PeriodicalId":21576,"journal":{"name":"Science China Life Sciences","volume":" ","pages":""},"PeriodicalIF":8.0,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143441800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treating incurable non-communicable diseases by targeting iron metabolism and ferroptosis.","authors":"Ruoxuan Ni, Jianwei Jiang, Fudi Wang, Junxia Min","doi":"10.1007/s11427-024-2787-y","DOIUrl":"https://doi.org/10.1007/s11427-024-2787-y","url":null,"abstract":"<p><p>Both iron metabolism and ferroptosis (an iron-dependent form of programmed cell death) have been connected to the development and progression of many currently incurable non-communicable diseases, including Alzheimer's disease, Parkinson's disease, multiple sclerosis, Huntington's disease, metabolic dysfunction-associated steatohepatitis, heart failure, and both treatment-relapsed and refractory cancers, such as pancreatic ductal adenocarcinoma and triple-negative breast cancer. Thus, understanding the relationship between iron and these diseases can pave the way for the development of novel therapeutic strategies. Here, we summarize the latest evidence supporting the pathological roles of dysregulated iron metabolism and ferroptosis in a wide range of preclinical animal models of these currently incurable non-communicable diseases. We also summarize the feasibility of targeting iron metabolism and ferroptosis for the prevention and treatment of iron- and ferroptosis-related diseases that currently have limited treatment options. In addition, we provide our perspectives on the challenges and promises regarding the translational potential of targeting dysregulated iron metabolism and ferroptosis to treat diseases, highlighting the future roadmap for developing iron- and ferroptosis-targeted therapeutics.</p>","PeriodicalId":21576,"journal":{"name":"Science China Life Sciences","volume":" ","pages":""},"PeriodicalIF":8.0,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143441817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exaptation of pectoral fins for olfaction in the spiny red gurnard (Chelidonichthys spinosus) through an ancient receptor.","authors":"Lisen Li, Deqian Fan, Chenglong Zhu, Zhuoya Liu, Wenji Huang, Peidong Xin, Huishan Yue, Mengying Li, Yufei Wang, Wenjie Xu, Jiangmin Zheng, Ye Li, Ziwei Yu, Jianzhong Ling, Qiang Qiu, Wen Wang, Chenguang Feng, Xiaojing Song, Kun Wang","doi":"10.1007/s11427-024-2746-7","DOIUrl":"10.1007/s11427-024-2746-7","url":null,"abstract":"","PeriodicalId":21576,"journal":{"name":"Science China Life Sciences","volume":" ","pages":"582-585"},"PeriodicalIF":8.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142668982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"DTD1 modulates synaptic efficacy by maintaining D-serine and D-aspartate homeostasis.","authors":"Xiao Liu, Chaojuan Yang, Zhuoran Lin, Jianing Li, Bin Yin, Xuepei Lei, Wei Han, Boqin Qiang, Pengcheng Shu, Chen Zhang, Xiaozhong Peng","doi":"10.1007/s11427-023-2681-y","DOIUrl":"10.1007/s11427-023-2681-y","url":null,"abstract":"<p><p>D-serine and D-aspartate are involved in N-methyl-D-aspartate receptor (NMDAR)-related physiological and pathological processes. D-aminoacyl-tRNA deacylase 1 (DTD1) may biochemically contribute to D-serine or D-aspartate production. However, it is unclear thus far whether DTD1 regulates D-serine or D-aspartate content in neurobiological processes. In the present research, we found that DTD1 was essential to maintain the D-serine or D-aspartate homeostasis, which was consistent with the phenomenon that DTD1-deficiency resulted in changes in the quantity changes of functional NMDAR subunits in postsynaptic compartments. Moreover, DTD1 played a considerable role in regulating dendritic morphology and synaptic structure. As a consequence, DTD1 affected neurobiological events, including the synaptic strength of the CA3-to-CA1 circuit, dendritic spine density of hippocampal pyramidal neurons, and behavioral performance of mice in the Morris water maze. These findings highlight the important role of DTD1 in synaptic transmission, neuronal morphology, and spatial learning and memory and suggest an undisclosed mechanism of DTD1 that participates the regulation of D-serine or D-aspartate homeostasis in hippocampal neurons.</p>","PeriodicalId":21576,"journal":{"name":"Science China Life Sciences","volume":" ","pages":"467-483"},"PeriodicalIF":8.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142473717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advancing RAS inhibition: broad-spectrum targeting and tumor-selective activity of RMC-7977 in cancer therapy.","authors":"Qunli Xiong, Yaguang Zhang","doi":"10.1007/s11427-024-2669-2","DOIUrl":"10.1007/s11427-024-2669-2","url":null,"abstract":"","PeriodicalId":21576,"journal":{"name":"Science China Life Sciences","volume":" ","pages":"586-587"},"PeriodicalIF":8.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142507073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemiology of liver diseases: global disease burden and forecasted research trends.","authors":"Jia Xiao, Fei Wang, Yuan Yuan, Jinhang Gao, Lu Xiao, Chao Yan, Feifei Guo, Jiajun Zhong, Zhaodi Che, Wei Li, Tian Lan, Frank Tacke, Vijay H Shah, Cui Li, Hua Wang, Erdan Dong","doi":"10.1007/s11427-024-2722-2","DOIUrl":"10.1007/s11427-024-2722-2","url":null,"abstract":"<p><p>We assessed the global incidence, mortality, and disability-adjusted life years (DALYs) associated with various liver diseases, including alcohol-related liver disease (ALD), hepatitis B/C virus infections (HBV or HCV), liver cancer, metabolic dysfunction-associated steatotic liver disease (MASLD), and other chronic liver diseases, from the 2019 Global Burden of Disease study. Additionally, we analyzed the global trends in hepatology research and drug development. From 2000 to 2019, prevalence rates increased for ALD, MASLD and other liver diseases, while they decreased for HBV, HCV, and liver cancer. Countries with a high socio-demographic index (SDI) exhibited the lowest mortality rates and DALYs. The burden of liver diseases varied due to factors like sex and region. In nine representative countries, MASLD, along with hepatobiliary cancer, showed highest increase in funding in hepatology research. Globally, the major research categories in hepatology papers from 2000 to 2019 were cancer, pathobiology, and MASLD. The United States (U.S.) was at the forefront of hepatology research, with China gradually increasing its influence over time. Hepatologists worldwide are increasingly focusing on studying the communication between the liver and other organs, while underestimating the research on ALD. Cancer, HCV, and MASLD were the primary diseases targeted for therapeutic development in clinical trials. However, the proportion of new drugs approved for the treatment of liver diseases was relatively low among all newly approved drugs in the U.S., China, Japan, and the European Union. Notably, there were no approved drug for the treatment of ALD in the world.</p>","PeriodicalId":21576,"journal":{"name":"Science China Life Sciences","volume":" ","pages":"541-557"},"PeriodicalIF":8.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142473719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing the ecological effects of the World's Largest Forestry Eco-engineering: Three-North Protective Forest Program within the initially scheduled range from 1978 to 2022.","authors":"Xiao Zheng, Jiaojun Zhu, G Geoff Wang, Qiaoling Yan, Tao Sun, Lining Song, Tian Gao, Yirong Sun, Xiufen Li, Kai Yang, Jinxin Zhang, Lizhong Yu, Ke Qi, Lanlin Zhao, Deliang Lu, Zhanyuan Lu","doi":"10.1007/s11427-024-2705-4","DOIUrl":"10.1007/s11427-024-2705-4","url":null,"abstract":"<p><p>China's Three-North Protective Forest Program (TNP) is the world's most ambitious afforestation project (ongoing from 1978 to 2050), which aims to increase forest coverage through afforestation and reforestation, protect agriculture, reduce soil erosion, and control desertification. Although TNP has been ongoing for 45 years, its rationales and effects remain uncertain. Here, we conducted a range-wide assessment of TNP by analyzing data from >10,000 scenes of satellite images and >50,000 field survey plots. The TNP range and definitions of shelterbelts, arboreal forests, and shrublands were changed during the study period, but we used the initial TNP range (4.07 million km²) and the definitions in 1978 for keeping the consistency, comparability, and comprehensiveness. The TNP increased forest coverage from 5.05% in 1978 to 9.69% in 2022, with arboreal forests, shrublands, and shelterbelts increasing by 42.5%, 184.4%, and 53.6%, respectively. However, only 40.1% of the 471,113 km² afforested area was established between 1978 and 2022. The well-established shelterbelts improved crop yield by 4.3%-9.5%, but only 10.2% of all the farmlands in TNP regions (TNR) were protected. The total area of soil erosion due to hydraulic forces was reduced by 447,363 km², with 61% of this reduction attributed to TNP. TNP contributed to the reduction of desertification by 15%, largely due to the low rate of afforestation success and the largely decreased grasslands. The total carbon sequestration from TNP was 1.96 Pg C. Moreover, water storage in TNR showed a decreasing trend, but the contribution rate of TNP was only 7.8%. Our results illustrate that forestry eco-engineering projects are feasible in the management and restoration of arid and semi-arid degraded lands, but attention must be paid to fully considering the ecological carrying capacity of water resources, matching the species to sites, strengthening the post-afforestation management, as well as keeping the balances between composite ecosystems.</p>","PeriodicalId":21576,"journal":{"name":"Science China Life Sciences","volume":" ","pages":"314-327"},"PeriodicalIF":8.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142897186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"AI empowers exploration of protein universe.","authors":"Wuke Wang, Xingxu Huang","doi":"10.1007/s11427-024-2673-9","DOIUrl":"10.1007/s11427-024-2673-9","url":null,"abstract":"","PeriodicalId":21576,"journal":{"name":"Science China Life Sciences","volume":" ","pages":"588-589"},"PeriodicalIF":8.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142353119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Graph based recurrent network for context specific synthetic lethality prediction.","authors":"Yuyang Jiang, Jing Wang, Yixin Zhang, ZhiWei Cao, Qinglong Zhang, Jinsong Su, Song He, Xiaochen Bo","doi":"10.1007/s11427-023-2618-y","DOIUrl":"10.1007/s11427-023-2618-y","url":null,"abstract":"<p><p>The concept of synthetic lethality (SL) has been successfully used for targeted therapies. To further explore SL for cancer therapy, identifying more SL interactions with therapeutic potential are essential. Recently, graph neural network-based deep learning methods have been proposed for SL prediction, which reduce the SL search space of wet-lab based methods. However, these methods ignore that most SL interactions depend strongly on genetic context, which limits the application of the predicted results. In this study, we proposed a graph recurrent network-based model for specific context-dependent SL prediction (SLGRN). In particular, we introduced a Graph Recurrent Network-based encoder to acquire a context-specific, low-dimensional feature representation for each node, facilitating the prediction of novel SL. SLGRN leveraged gate recurrent unit (GRU) and it incorporated a context-dependent-level state to effectively integrate information from all nodes. As a result, SLGRN outperforms the state-of-the-arts models for SL prediction. We subsequently validate novel SL interactions under different contexts based on combination therapy or patient survival analysis. Through in vitro experiments and retrospective clinical analysis, we emphasize the potential clinical significance of this context-specific SL prediction model.</p>","PeriodicalId":21576,"journal":{"name":"Science China Life Sciences","volume":" ","pages":"527-540"},"PeriodicalIF":8.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142473721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}