Science China Life Sciences最新文献_第3页

Erratum to: Does caudate lobe resection really improve the surgical outcomes of patients with hilar cholangiocarcinoma? A multicenter retrospective study. 尾状叶切除真的能改善肝门部胆管癌患者的手术效果吗？一项多中心回顾性研究。

IF 9.5 2区生物学

Science China Life Sciences Pub Date : 2025-10-01 Epub Date: 2025-08-08 DOI: 10.1007/s11427-025-3010-y

Ran Tao, Tong Yuan, Qi Cheng, Deyu Li, Qiumeng Liu, Chang Shu, Chuang Peng, Yongjun Chen, Xiaoping Chen, Erlei Zhang, Shuai Xiang

引用次数: 0

Global burden and characterization of hypertriglyceridemia-induced acute pancreatitis: results from a systematic review and a multi-center cohort study. 高甘油三酯血症引起的急性胰腺炎的全球负担和特征：来自系统评价和多中心队列研究的结果

IF 9.5 2区生物学

Science China Life Sciences Pub Date : 2025-10-01 Epub Date: 2025-06-23 DOI: 10.1007/s11427-024-2900-6

Zhengyang Fan, Yuelun Zhang, Jianing Li, Wenhua He, Xiaoyin Bai, Yanna Cai, Naishi Li, Feng Xie, Li Wen, Venkata Sandeep Akshintala, Yin Zhu, Dong Wu

{"title":"Global burden and characterization of hypertriglyceridemia-induced acute pancreatitis: results from a systematic review and a multi-center cohort study.","authors":"Zhengyang Fan, Yuelun Zhang, Jianing Li, Wenhua He, Xiaoyin Bai, Yanna Cai, Naishi Li, Feng Xie, Li Wen, Venkata Sandeep Akshintala, Yin Zhu, Dong Wu","doi":"10.1007/s11427-024-2900-6","DOIUrl":"10.1007/s11427-024-2900-6","url":null,"abstract":"To compare and characterize hypertriglyceridemia-induced acute pancreatitis (HTG-AP) across the geographical regions, we conducted a systematic review and a multi-center cohort study. We conducted a systematic review and random effects meta-analysis of studies reporting HTG-AP. Also, we separately characterized HTG-AP in a multi-center retrospective cohort study involving eight centers in China. The key outcomes of interest included the pooled proportion of HTG-AP and its severity parameters after adjusting for the effect of confounding factors through logistic regression. Our systematic review identified 110 studies from 15 countries accounting for 3,057,428 participants (35% female, median age 50 years). The pooled proportion of HTG-AP was 11.6% globally while the Eastern and Western countries reported the proportions as 16.3% and 5.4%, respectively (P<0.01). The pooled mortality rate was remarkably higher in Eastern countries (4.1%) than in Western countries (1.0%) (P<0.01). 3,224 participants (37% female, median age 48 years) were included in our multi-center cohort study, and the proportion of HTG-AP was much higher at 35.9% with a nearly three-fold higher mortality rate compared with acute pancreatitis (AP) due to other etiologies (odds ratio (OR): 2.77, 95% confidence interval (CI): 1.60 to 4.81). The proportion of patients with HTG-AP is remarkably higher in Eastern countries, particularly China, than in Western countries. Furthermore, compared with other causes of AP, HTG-AP has a poorer prognosis and may warrant aggressive management.","PeriodicalId":21576,"journal":{"name":"Science China Life Sciences","volume":" ","pages":"3010-3020"},"PeriodicalIF":9.5,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144476633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

JAK/STAT signaling sustains an intermediate basal cell population in prostate homeostasis and disease. JAK/STAT信号在前列腺稳态和疾病中维持中间基底细胞群。

IF 9.5 2区生物学

Science China Life Sciences Pub Date : 2025-10-01 Epub Date: 2025-06-23 DOI: 10.1007/s11427-025-2940-y

Jianglei Ma, Shancheng Ren

引用次数: 0

Porcine GWAS identifies ACOT11 as regulator for macrophage IL-1β maturation via IFNGR2 palmitoylation. 猪GWAS鉴定ACOT11通过IFNGR2棕榈酰化调节巨噬细胞IL-1β成熟。

IF 9.5 2区生物学

Science China Life Sciences Pub Date : 2025-10-01 Epub Date: 2025-07-25 DOI: 10.1007/s11427-025-2999-1

Meimei Zhang, Shaojuan Liu, Zebiao Wu, Chuanlong Wang, Hangchao Zhang, Jie Yang, Chunhe Guo, Manman Dai, Xiaofan Wang, Wenkai Ren

{"title":"Porcine GWAS identifies ACOT11 as regulator for macrophage IL-1β maturation via IFNGR2 palmitoylation.","authors":"Meimei Zhang, Shaojuan Liu, Zebiao Wu, Chuanlong Wang, Hangchao Zhang, Jie Yang, Chunhe Guo, Manman Dai, Xiaofan Wang, Wenkai Ren","doi":"10.1007/s11427-025-2999-1","DOIUrl":"10.1007/s11427-025-2999-1","url":null,"abstract":"Fatty acid metabolism mediates macrophage function; however, the underlying mechanism by which fatty acid metabolism regulates macrophage interleukin (IL)-1β production remains to be uncovered. Here, we used genome-wide association studies (GWAS) to identify several porcine serum IL-1β-related genes, such as the fatty acid metabolizing enzyme acyl-CoA thioesterase 11 (ACOT11). We then demonstrated that inflammatory macrophages have low expression of ACOT11, and ACOT11 overexpression inhibits IL-1β maturation from inflammatory macrophages. Mechanistically, ACOT11 promotes intracellular fatty acids accumulation, including eicosatetraenoic acid (EA) and stearic acid (SA), which inhibit activation of the Janus kinase (JAK)-signal transducer and activator of transcription (STAT) signaling through palmitoylation of interferon (IFN)-γ receptor (IFNGR) 2 at C261site. Furthermore, we also found that EA attenuates lipopolysaccharide (LPS)-induced sepsis in mice. Collectively, our findings reveal a mechanism involving ACOT11-mediated post-translational modification that regulates macrophage function and provide a promising therapeutic target for the treatment of inflammatory diseases associated with macrophages.","PeriodicalId":21576,"journal":{"name":"Science China Life Sciences","volume":" ","pages":"3037-3050"},"PeriodicalIF":9.5,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144718370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A strategy for the development of receptor-containing antibodies targeting malaria variant surface antigens. 针对疟疾变异表面抗原的含受体抗体的开发策略。

IF 9.5 2区生物学

Science China Life Sciences Pub Date : 2025-10-01 Epub Date: 2025-05-08 DOI: 10.1007/s11427-024-2914-2

Yizhuo Wang, Hengfang Tang, Jiarui Li, Wanxue Wang, Ming Li, Chenchen Zhu, Han Dai, Hongxin Zhao, Lubin Jiang, Bo Wu, Junfeng Wang

引用次数: 0

De novo origination of the micropeptide controlling kernel dehydration in maize. 控制玉米籽粒脱水的微肽的新生形成。

IF 9.5 2区生物学

Science China Life Sciences Pub Date : 2025-10-01 Epub Date: 2025-01-10 DOI: 10.1007/s11427-024-2814-1

Yuanliang Liu, Manman Li, Mingliang Xu

引用次数: 0

Antibody-based targeted protein degradation for membrane and extracellular proteins: emerging strategies and breakthroughs. 基于抗体的膜和细胞外蛋白靶向降解：新兴策略和突破。

IF 9.5 2区生物学

Science China Life Sciences Pub Date : 2025-10-01 Epub Date: 2025-06-23 DOI: 10.1007/s11427-025-2953-3

Rong Wei, Wenchen Pu, Yong Peng

引用次数: 0

Hot breath, quick exit: aphids flee mammalian heat via TRPA1. 热呼吸，快速出口：蚜虫通过TRPA1逃离哺乳动物的热量。

IF 9.5 2区生物学

Science China Life Sciences Pub Date : 2025-10-01 Epub Date: 2025-06-19 DOI: 10.1007/s11427-025-2925-9

Bing Wang, Lulu Yang, Jinjin Wei, Tianyu Huang, Bo Zhang, Jonathan Bohbot, Guirong Wang

引用次数: 0

The OsRqc1-OsVms1 module regulates the temperature threshold in thermo-sensitive genic male-sterile rice lines. OsRqc1-OsVms1模块调控温敏基因雄性不育水稻品系的温度阈值。

IF 9.5 2区生物学

Science China Life Sciences Pub Date : 2025-10-01 Epub Date: 2025-07-25 DOI: 10.1007/s11427-025-3018-9

Can Zhou, Bin Yan, Chunyan Liu, Jing Sun, Yuanzhu Yang, Xiaofeng Cao

{"title":"The OsRqc1-OsVms1 module regulates the temperature threshold in thermo-sensitive genic male-sterile rice lines.","authors":"Can Zhou, Bin Yan, Chunyan Liu, Jing Sun, Yuanzhu Yang, Xiaofeng Cao","doi":"10.1007/s11427-025-3018-9","DOIUrl":"10.1007/s11427-025-3018-9","url":null,"abstract":"Thermo-sensitive genic male-sterile (TGMS) lines are fertile at lower temperatures but male sterile above a critical sterility-inducing temperature (CSIT), which varies substantially across TGMS lines. Such lines are valuable resources for breeding two-line hybrid rice (Oryza sativa). However, as their utility is restricted by the CSIT, understanding its regulatory mechanisms has crucial breeding-associated implications. The thermo-sensitive genic male sterility 5 (tms5) mutation is common to most TGMS lines. We previously revealed that tms5 mutants failed to recycle cyclic phosphate (cP)-containing ΔCCA-tRNAs, particularly in pollen mother cells, resulting in fewer mature tRNAs, thereby causing TGMS. However, the CSIT-regulatory network in the tms5 lines remains unelucidated. Here, we characterized the CSIT-related ribosome-associated quality control 1 (OsRqc1) gene. OsRqc1 binds to the 60S ribosomal subunits and functions in ribosome-associated quality control. It also regulates the CSIT in tms5 lines by assisting OsVms1 in recruiting these subunits to generate cP-ΔCCA-tRNAs. Variations in a 6-bp repeat in the 5' untranslated region of OsRqc1 in rice subspecies affect its transcription, thereby altering the CSIT in tms5 lines. These findings reveal the role of an OsRqc1-OsVms1 module in regulating CSIT, providing valuable insights into genetic variations in OsRqc1. Such results may facilitate the molecular breeding of rice two-line hybrid tms5 lines with specific CSITs, which can adapt to regions with different environments.","PeriodicalId":21576,"journal":{"name":"Science China Life Sciences","volume":" ","pages":"3074-3087"},"PeriodicalIF":9.5,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144718372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multi-omics analysis revealed the addiction to glutamine and susceptibility to de novo lipogenesis of endometrial neoplasm. 多组学分析揭示了子宫内膜肿瘤对谷氨酰胺的依赖性和对新生脂肪生成的易感性。

IF 9.5 2区生物学

Science China Life Sciences Pub Date : 2025-10-01 Epub Date: 2025-07-24 DOI: 10.1007/s11427-024-2761-y

Yuemeng Zhu, Yingxin Zheng, Qing Zhang, Leshi Chen, Yitong Ouyang, Zhiqiang Song, Bing Zhao, Chao Gu, Beihua Kong, He Huang, Jin Li

{"title":"Multi-omics analysis revealed the addiction to glutamine and susceptibility to de novo lipogenesis of endometrial neoplasm.","authors":"Yuemeng Zhu, Yingxin Zheng, Qing Zhang, Leshi Chen, Yitong Ouyang, Zhiqiang Song, Bing Zhao, Chao Gu, Beihua Kong, He Huang, Jin Li","doi":"10.1007/s11427-024-2761-y","DOIUrl":"10.1007/s11427-024-2761-y","url":null,"abstract":"The endometrium is a proliferative tissue controlled by the menstrual cycle. Endometrial hyperplasia (EH) is a type of neoplastic disease that may develop into endometrial hyperplasia with atypia (EHA) or endometrial adenocarcinoma (EA). We performed a multi-omics analysis of a collection of endometrial tissues with four different proliferative statuses from two independent cohorts of patients. A positive association between the level of glutamine and malignancy, as well as addiction of EHA/EA neoplasms to glutamine, was identified. Further investigation revealed the dual mechanism by which glutamine influences the development of endometrial neoplasms. On one hand, glutamine regulates the level of c-MYC by controlling its translational process. On the other hand, glutamine is a major source of energy for endometrial neoplasms. Reprogramming the glutamine metabolism towards de novo lipogenesis affects the growth of endometrial adenocarcinoma in vitro, ex vivo and in vivo. Our study revealed the importance of maintaining metabolic homeostasis in endometrial tissues. The enhancement of de novo lipogenesis is a promising therapeutic strategy for treating endometrial adenocarcinoma.","PeriodicalId":21576,"journal":{"name":"Science China Life Sciences","volume":" ","pages":"2923-2933"},"PeriodicalIF":9.5,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144732981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0