小檗碱与水苏糖结合通过调节肠道微生物群和增加瘦素敏感性来预防肥胖。

IF 9.5 2区 生物学 Q1 BIOLOGY
Dan Wu, Feng Zhang, Huiying Wang, Lijun Xie, Bingdong Liu, Shanshan Xiao, Wei Chen, Yuqing Ye, Zhinan Chen, Guanghou Shui, Weimin Zeng, Liwei Xie, Fang Hu
{"title":"小檗碱与水苏糖结合通过调节肠道微生物群和增加瘦素敏感性来预防肥胖。","authors":"Dan Wu, Feng Zhang, Huiying Wang, Lijun Xie, Bingdong Liu, Shanshan Xiao, Wei Chen, Yuqing Ye, Zhinan Chen, Guanghou Shui, Weimin Zeng, Liwei Xie, Fang Hu","doi":"10.1007/s11427-024-2943-4","DOIUrl":null,"url":null,"abstract":"<p><p>Leptin resistance is a hallmark of obesity. Recent evidence shows that gut microbiota is associated with the development and progression of leptin resistance. However, whether intervention targeting gut microbiota can improve leptin sensitivity remains to be fully established. In the current investigation, we have demonstrated that co-administration of berberine, an isoquinoline alkaloid compound, and stachyose, a prebiotic, could enhance leptin sensitivity and reduce body weight in diet-induced obesity (DIO) mice, via an effect associated with gut microbiota modulation. Notably, the combination of berberine and stachyose significantly increased the abundance of Blautia producta, altered host purine metabolism, and elevated serum and hypothalamic levels of a purine metabolite, inosine. Furthermore, direct supplementation with inosine further ameliorated inflammation and endoplasmic reticulum stress in the hypothalamus and improved leptin sensitivity in obese mice. These findings suggest that berberine combined with stachyose represents a novel leptin sensitizer for obesity, acting through the modulation of gut microbiota and subsequently alteration in host purine metabolism, particularly with the involvement of inosine.</p>","PeriodicalId":21576,"journal":{"name":"Science China Life Sciences","volume":" ","pages":""},"PeriodicalIF":9.5000,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Berberine combined with stachyose protects against obesity by modulating gut microbiota and increasing leptin sensitivity.\",\"authors\":\"Dan Wu, Feng Zhang, Huiying Wang, Lijun Xie, Bingdong Liu, Shanshan Xiao, Wei Chen, Yuqing Ye, Zhinan Chen, Guanghou Shui, Weimin Zeng, Liwei Xie, Fang Hu\",\"doi\":\"10.1007/s11427-024-2943-4\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Leptin resistance is a hallmark of obesity. Recent evidence shows that gut microbiota is associated with the development and progression of leptin resistance. However, whether intervention targeting gut microbiota can improve leptin sensitivity remains to be fully established. In the current investigation, we have demonstrated that co-administration of berberine, an isoquinoline alkaloid compound, and stachyose, a prebiotic, could enhance leptin sensitivity and reduce body weight in diet-induced obesity (DIO) mice, via an effect associated with gut microbiota modulation. Notably, the combination of berberine and stachyose significantly increased the abundance of Blautia producta, altered host purine metabolism, and elevated serum and hypothalamic levels of a purine metabolite, inosine. Furthermore, direct supplementation with inosine further ameliorated inflammation and endoplasmic reticulum stress in the hypothalamus and improved leptin sensitivity in obese mice. These findings suggest that berberine combined with stachyose represents a novel leptin sensitizer for obesity, acting through the modulation of gut microbiota and subsequently alteration in host purine metabolism, particularly with the involvement of inosine.</p>\",\"PeriodicalId\":21576,\"journal\":{\"name\":\"Science China Life Sciences\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":9.5000,\"publicationDate\":\"2025-10-10\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Science China Life Sciences\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://doi.org/10.1007/s11427-024-2943-4\",\"RegionNum\":2,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Science China Life Sciences","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1007/s11427-024-2943-4","RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"BIOLOGY","Score":null,"Total":0}
引用次数: 0

摘要

瘦素抵抗是肥胖的标志。最近的证据表明,肠道微生物群与瘦素抵抗的发生和进展有关。然而,针对肠道菌群的干预是否能改善瘦素敏感性仍有待完全确定。在目前的研究中,我们已经证明,小檗碱(一种异喹啉生物碱化合物)和水苏糖(一种益生元)共同给药,可以通过与肠道微生物群调节相关的作用,增强瘦素敏感性,减轻饮食性肥胖(DIO)小鼠的体重。值得注意的是,小檗碱和水苏糖的组合显著增加了蓝毛藻产品的丰度,改变了宿主嘌呤代谢,提高了血清和下丘脑嘌呤代谢物肌苷的水平。此外,直接补充肌苷进一步改善了肥胖小鼠下丘脑的炎症和内质网应激,并改善了瘦素敏感性。这些发现表明,小檗碱联合水苏糖是一种新型的肥胖瘦素增敏剂,通过调节肠道微生物群,随后改变宿主嘌呤代谢,特别是肌苷的参与。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Berberine combined with stachyose protects against obesity by modulating gut microbiota and increasing leptin sensitivity.

Leptin resistance is a hallmark of obesity. Recent evidence shows that gut microbiota is associated with the development and progression of leptin resistance. However, whether intervention targeting gut microbiota can improve leptin sensitivity remains to be fully established. In the current investigation, we have demonstrated that co-administration of berberine, an isoquinoline alkaloid compound, and stachyose, a prebiotic, could enhance leptin sensitivity and reduce body weight in diet-induced obesity (DIO) mice, via an effect associated with gut microbiota modulation. Notably, the combination of berberine and stachyose significantly increased the abundance of Blautia producta, altered host purine metabolism, and elevated serum and hypothalamic levels of a purine metabolite, inosine. Furthermore, direct supplementation with inosine further ameliorated inflammation and endoplasmic reticulum stress in the hypothalamus and improved leptin sensitivity in obese mice. These findings suggest that berberine combined with stachyose represents a novel leptin sensitizer for obesity, acting through the modulation of gut microbiota and subsequently alteration in host purine metabolism, particularly with the involvement of inosine.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
CiteScore
15.10
自引率
8.80%
发文量
2907
审稿时长
3.2 months
期刊介绍: Science China Life Sciences is a scholarly journal co-sponsored by the Chinese Academy of Sciences and the National Natural Science Foundation of China, and it is published by Science China Press. The journal is dedicated to publishing high-quality, original research findings in both basic and applied life science research.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信