Scandinavian Journal of Immunology最新文献_第8页

Citomegalovirus Serology and Response to Autologous Haematopoietic Stem Cell Transplantation in Persons With Multiple Sclerosis. 多发性硬化症患者的Citomegalovirus血清学及对自体造血干细胞移植的反应

IF 1.6 4区医学

Scandinavian Journal of Immunology Pub Date : 2025-12-01 DOI: 10.1111/sji.70078

Luis Enrique Hamilton-Avilés, Moisés Manuel Gallardo-Pérez, Miranda Melgar-de-la-Paz, Paola Negrete-Rodríguez, Gloria Erendy Cruz-Pérez, Danae García-Vélez, Guillermo Ocaña-Ramm, Sofía Chávez Martínez, Juan Carlos Olivares-Gazca, Guillermo J Ruiz-Delgado, Guillermo J Ruiz-Argüelles

{"title":"Citomegalovirus Serology and Response to Autologous Haematopoietic Stem Cell Transplantation in Persons With Multiple Sclerosis.","authors":"Luis Enrique Hamilton-Avilés, Moisés Manuel Gallardo-Pérez, Miranda Melgar-de-la-Paz, Paola Negrete-Rodríguez, Gloria Erendy Cruz-Pérez, Danae García-Vélez, Guillermo Ocaña-Ramm, Sofía Chávez Martínez, Juan Carlos Olivares-Gazca, Guillermo J Ruiz-Delgado, Guillermo J Ruiz-Argüelles","doi":"10.1111/sji.70078","DOIUrl":"10.1111/sji.70078","url":null,"abstract":"Multiple sclerosis (MS) is a prevalent autoimmune disease with increasing incidence in certain populations, and autologous haematopoietic stem cell transplantation (aHSCT) represents an important therapeutic option. Cytomegalovirus (CMV) has been implicated in the pathophysiology of several immune-mediated conditions, prompting evaluation of its potential influence on transplant outcomes. We analysed MS patients who underwent aHSCT between 2015 and 2023 with 12-month follow-up using the 'Mexican method,' assessing clinical response through the change in Expanded Disability Status Scale (EDSS) score from pre-transplant to 12 months post-procedure. Among 135 patients, 93 were classified as responders and 42 as non-responders. Lower pre-transplant EDSS was associated with a better response (p = 0.001), and women showed significantly greater improvement following aHSCT (p = 0.012). Higher serum IgG anti-CMV levels correlated with improved clinical outcomes (p = 0.021), suggesting that prior CMV exposure may be linked to enhanced response to aHSCT. These findings highlight a potential modulatory role of CMV serostatus in transplant efficacy and support the need for further studies to clarify the biological basis and clinical relevance of this association.","PeriodicalId":21493,"journal":{"name":"Scandinavian Journal of Immunology","volume":"102 6","pages":"e70078"},"PeriodicalIF":1.6,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145661838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

C-Reactive Protein Mediates the Association Between Rheumatoid Arthritis and Immune Thrombocytopenia: An Observational and Mendelian Randomisation Study. c反应蛋白介导类风湿关节炎和免疫性血小板减少症之间的关联：一项观察性孟德尔随机研究

IF 1.6 4区医学

Scandinavian Journal of Immunology Pub Date : 2025-12-01 DOI: 10.1111/sji.70081

Wuxia Yang, Zhen Wang, Yanqi Song, Yang Liu, Huiying Kang, Aidi Wang, Baoshan Liu

{"title":"C-Reactive Protein Mediates the Association Between Rheumatoid Arthritis and Immune Thrombocytopenia: An Observational and Mendelian Randomisation Study.","authors":"Wuxia Yang, Zhen Wang, Yanqi Song, Yang Liu, Huiying Kang, Aidi Wang, Baoshan Liu","doi":"10.1111/sji.70081","DOIUrl":"10.1111/sji.70081","url":null,"abstract":"Thrombocytopenia has been increasingly observed in patients with rheumatoid arthritis (RA) in clinical practice. However, whether this association reflects a causal relationship remains unclear. This study aims to investigate the causal effect of RA on the risk of developing immune thrombocytopenia (ITP) and to evaluate the potential mediating role of C-reactive protein (CRP) in this relationship. This study combined a cross-sectional survey of data from the National Health and Nutrition Examination Survey (NHANES) 2003-2018 and two-sample Mendelian randomisation (MR) analyses. The observational study utilised multivariable logistic regression to examine the association between RA and ITP. The MR analysis used single-nucleotide polymorphisms (SNPs) as instrumental variables to evaluate the causal relationship between RA and ITP, as well as the mediating effect of CRP. The observational analysis demonstrated a significant positive association between RA and ITP after full adjustment for confounding variables (OR = 2.92, 95% CI: 1.93-4.44, p < 0.001). This association remained consistent across all predefined subgroups. MR analysis indicated a positive causal effect of genetically predicted RA on ITP risk (OR = 1.218, 95% CI: 1.093-1.356, p < 0.05). Mediation analysis estimated that CRP accounted for approximately 9% (95% CI: 3%-17%) of the total effect. The robustness of both observational and causal findings was upheld through sensitivity analyses. This study demonstrates a significant association between RA and ITP, with CRP partially mediating this relationship.","PeriodicalId":21493,"journal":{"name":"Scandinavian Journal of Immunology","volume":"102 6","pages":"e70081"},"PeriodicalIF":1.6,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145775558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Granulomatous and Lymphocytic Interstitial Lung Disease in Hyper-IgM Syndrome. 高igm综合征中的肉芽肿性和淋巴细胞间质性肺疾病。

IF 1.6 4区医学

Scandinavian Journal of Immunology Pub Date : 2025-12-01 DOI: 10.1111/sji.70074

Muhammed Aydin, Sezin Aydemir, Zeynep Meric, Dilan Demir Gumus, Betul Gemici Karaaslan, Ayca Aykut, Ayhan Gulsen Sucak, Kahraman Ahmet Salih Emri, Ayse Kalyoncu Ucar, Esra Yucel, Ayca Kiykim

引用次数: 0

From Spike to Strike: SARS-CoV-2 mRNA Vaccines Sensitise Tumours to PD-1/PD-L1 Blockade. 从刺突到打击：SARS-CoV-2 mRNA疫苗使肿瘤对PD-1/PD-L1阻断敏感

IF 1.6 4区医学

Scandinavian Journal of Immunology Pub Date : 2025-12-01 DOI: 10.1111/sji.70079

Julian Jamie Freen-van Heeren

引用次数: 0

Innate Immunity and Inflammation: Conuersim Between PAMPS and DAMPS. 先天免疫和炎症：PAMPS和DAMPS之间的联系。

IF 1.6 4区医学

Scandinavian Journal of Immunology Pub Date : 2025-11-01 DOI: 10.1111/sji.70060

Balachandran Ravindran

引用次数: 0

Oral and Skin Sensitisation to Peanut Show Different Immunological Features in Brown Norway Rats. 褐挪威大鼠对花生的口服和皮肤致敏表现出不同的免疫特性。

IF 1.6 4区医学

Scandinavian Journal of Immunology Pub Date : 2025-11-01 DOI: 10.1111/sji.70069

Tiffany K S Sztuk, Jeppe M Larsen, Neil M Rigby, Anne-Sofie R Ballegaard, Irina Pozdnyakova, Stef J Koppelman, Alan R Mackie, Katrine L Bøgh

{"title":"Oral and Skin Sensitisation to Peanut Show Different Immunological Features in Brown Norway Rats.","authors":"Tiffany K S Sztuk, Jeppe M Larsen, Neil M Rigby, Anne-Sofie R Ballegaard, Irina Pozdnyakova, Stef J Koppelman, Alan R Mackie, Katrine L Bøgh","doi":"10.1111/sji.70069","DOIUrl":"10.1111/sji.70069","url":null,"abstract":"Food allergy may develop after both oral and skin exposure to food allergens. Identifying immunological features associated with the sensitisation route is important for understanding the extent to which patients are sensitised through the oral or skin route and may be required to improve food allergy immunotherapy. Thus, the present study aimed at comparing the immunological features of peanut sensitisation induced through the oral and skin route in Brown Norway (BN) rat models. Sensitisation to peanut protein extract (PPE) was induced via oral or skin administration in BN rats. Allergy development was analysed by ELISA for PPE- and major allergen-specific IgE levels and by ear swelling responses to native and denatured PPE. Intestinal and skin tissues were analysed by flow cytometry for immune cell compositions and by TaqMan PCR for the expression of cytokines. Oral and skin sensitisation showed distinct patterns of specific IgE against the major peanut allergens. Conformational IgE epitopes dominated both routes of sensitisation. Skin sensitisation was associated with the activation of T cells and the expansion of antigen presenting cells in both the intestine and skin, whereas oral sensitisation showed a limited effect on immune cell composition and activation. Oral and skin sensitisation were associated with different intestinal cytokine expression profiles. Oral and skin sensitisation drive different responses to the major peanut allergens and promote different immunological responses in the intestine.","PeriodicalId":21493,"journal":{"name":"Scandinavian Journal of Immunology","volume":"102 5","pages":"e70069"},"PeriodicalIF":1.6,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12623298/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145542074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mycobacterial Infections in Wiskott Aldrich Syndrome: A Predisposition or Coincidence? Wiskott Aldrich综合征的分枝杆菌感染：易感性还是巧合？

IF 1.6 4区医学

Scandinavian Journal of Immunology Pub Date : 2025-11-01 DOI: 10.1111/sji.70070

Dev Desai, Loganathan Sathish Kumar, Simar Rajan Singh, Pratibha Suku, Saniya Sharma, Sangeetha Siniah, Amit Rawat, Deepti Suri

引用次数: 0

Common Variable Immune Deficiency Disorders (CVID) in the Indigenous Māori of Aotearoa (New Zealand) Are Associated With a High Prevalence of Bronchiectasis and Complete IgA Deficiency. 新西兰Aotearoa土著人的常见可变免疫缺陷疾病（CVID）与支气管扩张和完全IgA缺乏症的高发率有关。

IF 1.6 4区医学

Scandinavian Journal of Immunology Pub Date : 2025-11-01 DOI: 10.1111/sji.70068

Rohan Ameratunga, Catherine A Byrnes, Anthony Jordan, Richard Steele, Caroline Allan, See-Tarn Woon, Maia Brewerton

{"title":"Common Variable Immune Deficiency Disorders (CVID) in the Indigenous Māori of Aotearoa (New Zealand) Are Associated With a High Prevalence of Bronchiectasis and Complete IgA Deficiency.","authors":"Rohan Ameratunga, Catherine A Byrnes, Anthony Jordan, Richard Steele, Caroline Allan, See-Tarn Woon, Maia Brewerton","doi":"10.1111/sji.70068","DOIUrl":"10.1111/sji.70068","url":null,"abstract":"The New Zealand (NZ) Common Variable Immunodeficiency Disorders (CVID) study (NZCS) is a long-term prospective cohort study, which seeks to better understand the proximal causes and sequelae of CVID. Patients were accepted to the NZCS if they had a diagnosis of CVID. After informed consent, clinical and demographic data were obtained by an interviewer-assisted questionnaire. Computerised case notes and laboratory results, linked to each patient's National Health Index (NHI) number, were also reviewed. In the current analysis, ethnic-specific data was obtained on the prevalence of CVID and its sequelae in NZ. One hundred and eight patients with a diagnosis of CVID were enrolled in the NZCS, comprising approximately 70% of patients known to have CVID in NZ. There was a much greater prevalence of bronchiectasis in Māori (79%) compared to Caucasian CVID patients (38%). Māori patients with CVID develop symptoms at a younger age and have an increased number of severe infections prior to diagnosis. Māori CVID patients with bronchiectasis had a higher prevalence of complete IgA deficiency compared to Caucasian CVID patients with bronchiectasis. In contrast to Caucasian patients with CVID, autoimmune and inflammatory sequelae were much less common in Māori. This study also demonstrated worsening diagnostic delays in patients with CVID in NZ. The Indigenous Māori of Aotearoa have a much more aggresssive early-onset, infection-only CVID variant compared to Caucasian New Zealanders.","PeriodicalId":21493,"journal":{"name":"Scandinavian Journal of Immunology","volume":"102 5","pages":"e70068"},"PeriodicalIF":1.6,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145565099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Expansion of Myeloid-Derived Suppressor Cells and Lymphocyte Apoptosis Beyond B-Cell Deficiency in X-Linked Agammaglobulinemia. x -连锁无球蛋白血症中骨髓源性抑制细胞的扩增和淋巴细胞凋亡超越b细胞缺乏。

IF 1.6 4区医学

Scandinavian Journal of Immunology Pub Date : 2025-11-01 DOI: 10.1111/sji.70063

Ayca Ceylan, Ilknur Kulhas Celik, Sevgi Keles, Figen Celebi Celik, Yasin Karali, Zeynep Meric, Zehra Sule Haskologlu, Mehmet Geyik, Selcen Bozkurt, Nermin Kapcı, Saliha Esenboga, Esra Ozek Yucel, Nesrin Gulez, Neslihan Edeer Karaca, Sevgi Bilgic Eltan, Sukru Nail Guner, Cigdem Aydogmus, Tugba Cihan Guler, Mehmet Halil Celiksoy, Esra Karabiber, Ferah Genel, Esin Figen Doğu, Elif Karakoc-Aydiner, Deniz Cagdas, Guzide Aksu, Ayca Kiykim, Sara Sebnem Kilic, Ismail Reisli, Kamile Aydan Ikinciogullari, Hasibe Artac

{"title":"Expansion of Myeloid-Derived Suppressor Cells and Lymphocyte Apoptosis Beyond B-Cell Deficiency in X-Linked Agammaglobulinemia.","authors":"Ayca Ceylan, Ilknur Kulhas Celik, Sevgi Keles, Figen Celebi Celik, Yasin Karali, Zeynep Meric, Zehra Sule Haskologlu, Mehmet Geyik, Selcen Bozkurt, Nermin Kapcı, Saliha Esenboga, Esra Ozek Yucel, Nesrin Gulez, Neslihan Edeer Karaca, Sevgi Bilgic Eltan, Sukru Nail Guner, Cigdem Aydogmus, Tugba Cihan Guler, Mehmet Halil Celiksoy, Esra Karabiber, Ferah Genel, Esin Figen Doğu, Elif Karakoc-Aydiner, Deniz Cagdas, Guzide Aksu, Ayca Kiykim, Sara Sebnem Kilic, Ismail Reisli, Kamile Aydan Ikinciogullari, Hasibe Artac","doi":"10.1111/sji.70063","DOIUrl":"10.1111/sji.70063","url":null,"abstract":"X-linked agammaglobulinemia (XLA) is caused by Bruton tyrosine kinase gene mutations, leading to B-cell deficiency. This study aimed to investigate myeloid-derived suppressor cells (MDSCs) frequency, lymphocyte apoptosis and clinical significance in patients with XLA. The study comprised 46 paediatric (mean age: 9.9 ± 4.8 years) and 21 adult patients (24.6 ± 5.9 years). Total MDSCs (HLA-DR-CD33+CD11b+) were subdivided into CD15+ polymorphonuclear (PMN-MDSCs) and CD14+ monocytic (M-MDSCs) and analysed by flow cytometry. The paediatric XLA patients had increased M-MDSCs and early apoptotic lymphocyte frequency compared to healthy subjects. The mean diagnostic delay was positively correlated with early apoptotic CD3+ and CD4+ T-cells. Seventeen patients (14 adults and 3 children) had bronchiectasis. PMN-MDSCs were higher in adult patients than in paediatric patients. Increased PMN-MDSCs in adults with XLA suggest the presence of chronic inflammation in patients with bronchiectasis. The study findings broaden understanding of XLA's complex immunopathology and highlight the need for more comprehensive immune monitoring of these patients beyond antibody production.","PeriodicalId":21493,"journal":{"name":"Scandinavian Journal of Immunology","volume":"102 5","pages":"e70063"},"PeriodicalIF":1.6,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145482828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Role of CD36 and Its Regulatory Mechanisms in Metabolic Dysregulation and Tumorigenesis. CD36在代谢失调和肿瘤发生中的作用及其调控机制。

IF 1.6 4区医学

Scandinavian Journal of Immunology Pub Date : 2025-11-01 DOI: 10.1111/sji.70065

Chunyu Tong, Wenzhi Feng, Honghao Yu, Qi Liu, Yimin Liang, Di Lan, Qianyi Liu, Bocui Song

引用次数: 0