Scandinavian Journal of Immunology最新文献_第9页

Sirolimus is effective and safe in childhood relapsed-refractory autoimmune cytopenias: A multicentre study. 西罗莫司对儿童复发-难治性自身免疫性细胞减少症既有效又安全：一项多中心研究。

IF 4.1 4区医学

Scandinavian Journal of Immunology Pub Date : 2024-08-01 Epub Date: 2024-05-13 DOI: 10.1111/sji.13376

Sultan Okur Acar, Neryal Tahta, Işık Odaman Al, Melek Erdem, Salih Gözmen, Tuba Hilkay Karapınar, Burcu Kılınç, Tiraje Celkan, Serap Kirkiz, Ülker Koçak, Hale Ören, Ayşen Türedi Yıldırım, Esra Arslantaş, Aylin Canbolat Ayhan, Yeşim Oymak

{"title":"Sirolimus is effective and safe in childhood relapsed-refractory autoimmune cytopenias: A multicentre study.","authors":"Sultan Okur Acar, Neryal Tahta, Işık Odaman Al, Melek Erdem, Salih Gözmen, Tuba Hilkay Karapınar, Burcu Kılınç, Tiraje Celkan, Serap Kirkiz, Ülker Koçak, Hale Ören, Ayşen Türedi Yıldırım, Esra Arslantaş, Aylin Canbolat Ayhan, Yeşim Oymak","doi":"10.1111/sji.13376","DOIUrl":"10.1111/sji.13376","url":null,"abstract":"Autoimmune cytopenias are a heterogeneous group of disorders characterized by immune-mediated destruction of haematopoietic cell lines. Effective and well-tolerated treatment options for relapsed-refractory immune cytopenias are limited. In this study, the aim was to evaluate the efficacy and safety of sirolimus in this disease group within the paediatric age group. The study enrolled patients in the paediatric age group who used sirolimus with a diagnosis of immune cytopenia between December 2010 and December 2020, followed at six centres in Turkey. Of the 17 patients, five (29.4%) were treated for autoimmune haemolytic anaemia (AIHA), six (35.2%) for immune thrombocytopenic purpura (ITP) and six (35.2%) for Evans syndrome (ES). The mean response time was 2.7 months (range, 0-9 months). Complete response (CR) and partial response (PR) were obtained in 13 of 17 patients (76.4%) and nonresponse (NR) in four patients (23.5%). Among the 13 patients who achieved CR, three of them were NR in the follow-up and two of them had remission with low-dose steroid and sirolimus. Thus, overall response rate (ORR) was achieved in 12 of 17 patients (70.5%). In conclusion, sirolimus may be an effective and safe option in paediatric patients with relapsed-refractory immune cytopenia.","PeriodicalId":21493,"journal":{"name":"Scandinavian Journal of Immunology","volume":" ","pages":"e13376"},"PeriodicalIF":4.1,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140916880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Genetic polymorphisms in IL-2, IL-10 and FOXP3 are associated with autoimmune neutropenia in early childhood and autoantibody specificity in a Danish cohort. 在丹麦的一个队列中，IL-2、IL-10 和 FOXP3 的基因多态性与幼儿期自身免疫性中性粒细胞减少症和自身抗体特异性有关。

IF 4.1 4区医学

Scandinavian Journal of Immunology Pub Date : 2024-08-01 Epub Date: 2024-05-15 DOI: 10.1111/sji.13374

Kirstine Kløve-Mogensen, Rudi Steffensen, Tania Nicole Masmas, Andreas Glenthøj, Christina Friis Jensen, Paul Ratcliffe, Petter Höglund, Henrik Hasle, Kaspar René Nielsen, Thure Mors Haunstrup

{"title":"Genetic polymorphisms in IL-2, IL-10 and FOXP3 are associated with autoimmune neutropenia in early childhood and autoantibody specificity in a Danish cohort.","authors":"Kirstine Kløve-Mogensen, Rudi Steffensen, Tania Nicole Masmas, Andreas Glenthøj, Christina Friis Jensen, Paul Ratcliffe, Petter Höglund, Henrik Hasle, Kaspar René Nielsen, Thure Mors Haunstrup","doi":"10.1111/sji.13374","DOIUrl":"10.1111/sji.13374","url":null,"abstract":"Autoimmune neutropenia (AIN) in early childhood is characterized by chronic neutropenia and positivity for human neutrophil antibodies (HNA), resulting in the excessive destruction of neutrophils. The association between regulatory T cells (Tregs) and AIN has been described, and in this study, we investigated three Treg-associated genes, IL-2, IL-10 and FOXP3. The frequencies of three single nucleotide polymorphisms (SNPs) in IL-2 -330T>G (rs2069762), +114G>T (rs2069763) and IVS3-116 A>G (rs2069772), four SNPs in IL-10 -3575T>A (rs1800890), -1082G>A (rs1800896), -819 C>T (rs1800871) and -592 C>A (rs1800872) and three SNPs in FOXP3 -3499 A>G (rs3761547), -3279 C>A (rs3761548) and -924 A>G (rs2232365) were compared between 166 Danish AIN patients and 358 healthy controls. Disease association was observed for IL-2 IVS3-116 GG (p = 0.0081, OR = 0.35 [0.15-0.80]), IL-10 -3575 TT (p = 0.0078, OR = 1.71 [1.16-2.54]) and IL-10 -1082 AA (p = 0.014, OR = 1.76 [1.14-2.72]) in all patients and FOXP3 -924 (p = 0.0005, A OR = 0.41 [0.25-0.68] and G OR = 2.42 [1.46-4.01]) in male patients. None of the associations were linked to antibody specificity. Disease-associated haplotypes were observed in IL-2 and FOXP3. IL-2 -330T/+114 T/IVS3-116A was associated with anti-FcγRIIIb-positive patients (p = 0.012, OR = 2.07 [1.18-3.62]). FOXP3 -3499A/-3279C/-924A was associated with anti-HNA-1a-positive male patients (p = 0.016, OR = 0.41 [0.20-0.83]), and ACG was associated with female patients, both in the combined group (p = 0.006, OR = NA) and the anti-FcγRIIIb-positive group (p = 0.002, OR = NA). We conclude that our findings reveal a correlation between SNP in Treg-associated genes and AIN, indicating that AIN could be driven by dysfunction of immune homeostatic-evolving Tregs.","PeriodicalId":21493,"journal":{"name":"Scandinavian Journal of Immunology","volume":" ","pages":"e13374"},"PeriodicalIF":4.1,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140944301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The quantum model of T-cell activation: Revisiting immune response theories. T 细胞激活的量子模型：重新审视免疫反应理论

IF 4.1 4区医学

Scandinavian Journal of Immunology Pub Date : 2024-08-01 Epub Date: 2024-05-15 DOI: 10.1111/sji.13375

Masoud H Manjili, Saeed H Manjili

{"title":"The quantum model of T-cell activation: Revisiting immune response theories.","authors":"Masoud H Manjili, Saeed H Manjili","doi":"10.1111/sji.13375","DOIUrl":"10.1111/sji.13375","url":null,"abstract":"Our understanding of the immune response is far from complete, missing out on more detailed explanations that could be provided by molecular insights. To bridge this gap, we introduce the quantum model of T-cell activation. This model suggests that the transfer of energy during protein phosphorylation within T cells is not a continuous flow but occurs in discrete bursts, or 'quanta', of phosphates. This quantized energy transfer is mediated by oscillating cycles of receptor phosphorylation and dephosphorylation, initiated by dynamic 'catch-slip' pulses in the peptide-major histocompatibility complex-T-cell receptor (pMHC-TcR) interactions. T-cell activation is predicated upon achieving a critical threshold of catch-slip pulses at the pMHC-TcR interface. Costimulation is relegated to a secondary role, becoming crucial only when the frequency of pMHC-TcR catch-slip pulses does not meet the necessary threshold for this quanta-based energy transfer. Therefore, our model posits that it is the quantum nature of energy transfer-not the traditional signal I or signal II-that plays the decisive role in T-cell activation. This paradigm shift highlights the importance of understanding T-cell activation through a quantum lens, offering a potentially transformative perspective on immune response regulation.","PeriodicalId":21493,"journal":{"name":"Scandinavian Journal of Immunology","volume":" ","pages":"e13375"},"PeriodicalIF":4.1,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11250909/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140944479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The effect of stress on the antibody response after vaccination in children aged 0-18 years: A systematic review. 压力对 0-18 岁儿童接种疫苗后抗体反应的影响：系统综述。

IF 4.1 4区医学

Scandinavian Journal of Immunology Pub Date : 2024-08-01 Epub Date: 2024-06-24 DOI: 10.1111/sji.13394

Rikke Svensson, Michelle Malon, Lone G Stensballe, Steffen U Thorsen, Jannet Svensson

{"title":"The effect of stress on the antibody response after vaccination in children aged 0-18 years: A systematic review.","authors":"Rikke Svensson, Michelle Malon, Lone G Stensballe, Steffen U Thorsen, Jannet Svensson","doi":"10.1111/sji.13394","DOIUrl":"10.1111/sji.13394","url":null,"abstract":"Stress has been associated with less effective vaccine responses in adults. This review aims to investigate the evidence for a similar association in children. A systematic review search was conducted in January 2021 in three databases: Medline, Embase and PsycInfo. An updated search of the Medline database was systematically conducted until the most recent update on September 25th, 2023, to ensure the inclusion of the most current research available. Keywords related to stress, vaccines and children were used, and a total of 7263 (+1528) studies were screened by two independent investigators. Six studies met the inclusion criteria for data extraction and analysis. For quality assessment of the studies, the risk of bias in non-randomized studies-of interventions (ROBINS-I) tool was applied. Most of the studies suggest a negative role of stress on vaccine responses. However, the scarcity of studies, lack of confirmatory studies, risk of bias and heterogeneity according to age, type of vaccine, measures of stress and vaccine responses prevent a clear conclusion. Future studies should emphasize the use of as strict study designs as possible, including well-defined stress metrics and thorough examination of both pre- and post-vaccination responses. Systematic review registration: Prospero CRD42021230490.","PeriodicalId":21493,"journal":{"name":"Scandinavian Journal of Immunology","volume":" ","pages":"e13394"},"PeriodicalIF":4.1,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141459077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

IFIH1 loss of function predisposes to inflammatory and SARS-CoV-2-related infectious diseases. IFIH1 功能缺失易引发炎症和与 SARS-CoV-2 相关的传染病。

IF 4.1 4区医学

Scandinavian Journal of Immunology Pub Date : 2024-08-01 Epub Date: 2024-05-16 DOI: 10.1111/sji.13373

Rania Najm, Lemis Yavuz, Ruchi Jain, Maha El Naofal, Sathishkumar Ramaswamy, Walid Abuhammour, Tom Loney, Norbert Nowotny, Alawi Alsheikh-Ali, Ahmad Abou Tayoun, Richard K Kandasamy

{"title":"IFIH1 loss of function predisposes to inflammatory and SARS-CoV-2-related infectious diseases.","authors":"Rania Najm, Lemis Yavuz, Ruchi Jain, Maha El Naofal, Sathishkumar Ramaswamy, Walid Abuhammour, Tom Loney, Norbert Nowotny, Alawi Alsheikh-Ali, Ahmad Abou Tayoun, Richard K Kandasamy","doi":"10.1111/sji.13373","DOIUrl":"10.1111/sji.13373","url":null,"abstract":"The IFIH1 gene, encoding melanoma differentiation-associated protein 5 (MDA5), is an indispensable innate immune regulator involved in the early detection of viral infections. Previous studies described MDA5 dysregulation in weakened immunological responses, and increased susceptibility to microbial infections and autoimmune disorders. Monoallelic gain-of-function of the IFIH1 gene has been associated with multisystem disorders, namely Aicardi-Goutieres and Singleton-Merten syndromes, while biallelic loss causes immunodeficiency. In this study, nine patients suffering from recurrent infections, inflammatory diseases, severe COVID-19 or multisystem inflammatory syndrome in children (MIS-C) were identified with putative loss-of-function IFIH1 variants by whole-exome sequencing. All patients revealed signs of lymphopaenia and an increase in inflammatory markers, including CRP, amyloid A, ferritin and IL-6. One patient with a pathogenic homozygous variant c.2807+1G>A was the most severe case showing immunodeficiency and glomerulonephritis. The c.1641+1G>C variant was identified in the heterozygous state in patients suffering from periodic fever, COVID-19 or MIS-C, while the c.2016delA variant was identified in two patients with inflammatory bowel disease or MIS-C. There was a significant association between IFIH1 monoallelic loss of function and susceptibility to infections in males. Expression analysis showed that PBMCs of one patient with a c.2016delA variant had a significant decrease in ISG15, IFNA and IFNG transcript levels, compared to normal PBMCs, upon stimulation with Poly(I:C), suggesting that MDA5 receptor truncation disrupts the immune response. Our findings accentuate the implication of rare monogenic IFIH1 loss-of-function variants in altering the immune response, and severely predisposing patients to inflammatory and infectious diseases, including SARS-CoV-2-related disorders.","PeriodicalId":21493,"journal":{"name":"Scandinavian Journal of Immunology","volume":" ","pages":"e13373"},"PeriodicalIF":4.1,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140959048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Role of AKR1B10 in inflammatory diseases. AKR1B10 在炎症性疾病中的作用

IF 4.1 4区医学

Scandinavian Journal of Immunology Pub Date : 2024-08-01 Epub Date: 2024-05-20 DOI: 10.1111/sji.13390

Min Guo, Tao Wang, Wenjun Ge, Chenran Ren, Ben Chi-Bun Ko, Xi Zeng, Deliang Cao

{"title":"Role of AKR1B10 in inflammatory diseases.","authors":"Min Guo, Tao Wang, Wenjun Ge, Chenran Ren, Ben Chi-Bun Ko, Xi Zeng, Deliang Cao","doi":"10.1111/sji.13390","DOIUrl":"10.1111/sji.13390","url":null,"abstract":"Inflammation is an important pathophysiological process in many diseases; it has beneficial and harmful effects. When exposed to various stimuli, the body triggers an inflammatory response to eliminate invaded pathogens and damaged tissues to maintain homeostasis. However, uncontrollable persistent or excessive inflammatory responses may damage tissues and induce various diseases, such as metabolic diseases (e.g. diabetes), autoimmune diseases, nervous system-related diseases, digestive system-related diseases, and even tumours. Aldo-keto reductase 1B10 (AKR1B10) is an important player in the development and progression of multiple diseases, such as tumours and inflammatory diseases. AKR1B10 is upregulated in solid tumours, such as hepatocellular carcinoma (HCC), non-small cell lung carcinoma, and breast cancer, and is a reliable serum marker. However, information on the role of AKR1B10 in inflammation is limited. In this study, we summarized the role of AKR1B10 in inflammatory diseases, including its expression, functional contribution to inflammatory responses, and regulation of signalling pathways related to inflammation. We also discussed the role of AKR1B10 in glucose and lipid metabolism and oxidative stress. This study provides novel information and increases the understanding of clinical inflammatory diseases.","PeriodicalId":21493,"journal":{"name":"Scandinavian Journal of Immunology","volume":" ","pages":"e13390"},"PeriodicalIF":4.1,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141071319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mite-negative allergic rhinitis: A model of the regulation mechanism of atopy onset. 螨阴性过敏性鼻炎：过敏性鼻炎发病调节机制模型。

IF 3.7 4区医学

Scandinavian Journal of Immunology Pub Date : 2024-06-01 Epub Date: 2024-03-31 DOI: 10.1111/sji.13367

Yasuhiro Horiuchi

引用次数: 0

Major low-energy trauma results in non-specific immunoglobulin generation without evidence for specific autoantibody production: A prospective cohort study. 重大低能量创伤会导致非特异性免疫球蛋白生成，但无证据表明会产生特异性自身抗体：一项前瞻性队列研究。

IF 3.7 4区医学

Scandinavian Journal of Immunology Pub Date : 2024-06-01 Epub Date: 2024-03-25 DOI: 10.1111/sji.13368

Henrik Eckardt, Nicolas Bless, Ingmar Heijnen, Mario Morgenstern, Josephine Nehring, Andrea Kieninger-Gräfitsch, Martine Bouchenaki, Vanessa Durandin, Silke Purschke, Ina Schmidt, Loraine Pascale Kouba, Marten Trendelenburg, Eliska Potlukova

{"title":"Major low-energy trauma results in non-specific immunoglobulin generation without evidence for specific autoantibody production: A prospective cohort study.","authors":"Henrik Eckardt, Nicolas Bless, Ingmar Heijnen, Mario Morgenstern, Josephine Nehring, Andrea Kieninger-Gräfitsch, Martine Bouchenaki, Vanessa Durandin, Silke Purschke, Ina Schmidt, Loraine Pascale Kouba, Marten Trendelenburg, Eliska Potlukova","doi":"10.1111/sji.13368","DOIUrl":"10.1111/sji.13368","url":null,"abstract":"Cellular debris resulting from large trauma might overwhelm the scavenger mechanisms and lead to autoimmune reactions. We analysed whether a major well-defined trauma in humans induces laboratory signs of transient autoimmunity in the months after the insult. We included 50 patients with pertrochanteric femur fracture undergoing intramedullary nail osteosynthesis in a prospective cohort study and followed them at 3-4 days, 6 weeks, 12 weeks and 12 months postoperatively. By standard techniques, we assessed levels of total immunoglobulins, anti-nuclear antibodies (ANA), anti-cardiolipin antibodies, anti-dsDNA antibodies and anti-C1q antibodies, as well as antibodies against cytomegalovirus (CMV) as a control. Blood leukocyte differential and lymphocyte subpopulations were determined at baseline and in the first two postoperative samples. The mean age of the patients reached 80.1 years, and 23 (46%) completed all visits. Serum concentrations of total IgG, IgM and IgA increased at all follow-up time points. The ANA fluorescence light intensity units increased at 12 weeks and 12 months postoperatively (p < 0.0001), but the proportion of ANA-positive patients did not change (35%). The values of anti-C1q mildly increased at all follow-up visits, but not the ratio to total IgG. Anti-dsDNA remained negative in all patients, and anti-cardiolipin IgG/IgM antibodies did not change. Anti-CMV IgG antibodies increased significantly at all follow-up visits, without change in the ratio to total IgG. Flow cytometry showed an increased proportion of B-cells 3-4 days postoperatively. In conclusion, major musculoskeletal trauma in elderly patients induces a generalized non-specific increase in immunoglobulin production without laboratory signs for enhanced systemic autoimmunity.","PeriodicalId":21493,"journal":{"name":"Scandinavian Journal of Immunology","volume":" ","pages":"e13368"},"PeriodicalIF":3.7,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140288900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Isoliquiritigenin limits inflammasome activation of macrophage via docking into Syk to alleviate murine non‐alcoholic fatty liver disease Isoliquiritigenin 通过与 Syk 对接限制巨噬细胞炎性体的激活，从而缓解小鼠非酒精性脂肪肝的病情

IF 3.7 4区医学

Scandinavian Journal of Immunology Pub Date : 2024-04-27 DOI: 10.1111/sji.13371

Xiangyu Hu, Chunmiao Hu, Liting Liao, Huimin Zhang, Xingmeng Xu, Jie Xiang, Guotao Lu, Xiaoqin Jia, Hongwei Xu, Weijuan Gong

{"title":"Isoliquiritigenin limits inflammasome activation of macrophage via docking into Syk to alleviate murine non‐alcoholic fatty liver disease","authors":"Xiangyu Hu, Chunmiao Hu, Liting Liao, Huimin Zhang, Xingmeng Xu, Jie Xiang, Guotao Lu, Xiaoqin Jia, Hongwei Xu, Weijuan Gong","doi":"10.1111/sji.13371","DOIUrl":"https://doi.org/10.1111/sji.13371","url":null,"abstract":"Isoliquiritigenin (ISL) is a chalcone‐type flavonoid derived from the root of licorice with antioxidant, anti‐inflammatory, anti‐tumour and neuroprotective properties. ISL has been proven to downregulate the productions of IL‐1β, TNF‐α and IL‐6 by macrophages. However, detailed molecular mechanisms of this modulation remain elusive. Here, ISL suppressed Syk phosphorylation and CD80, CD86, IL‐1β, TNF‐α and IL‐6 expressions in lipopolysaccharide‐stimulated macrophages ex vivo. ApoC3‐transgenic (ApoC3TG) mice had more activated macrophages. ISL was also able to downregulate the inflammatory activities of macrophages from ApoC3TG mice. Administration of ISL inhibited Syk activation and inflammatory activities of macrophages in ApoC3TG mice in vivo. The treatment of ISL further alleviated MCD‐induced non‐alcoholic fatty liver disease (NAFLD) in wild‐type and ApoC3TG mice, accompanied by less recruitment and activation of liver macrophages. Due to the inhibition of Syk phosphorylation, ISL‐treated macrophages displayed less production of cytoplasmic ROS, NLRP3, cleaved‐GSDMD and cleaved‐IL‐1β, suggesting less inflammasome activation. Finally, the molecular docking study demonstrated that ISL bound to Syk directly with the Kd of 1.273 × 10−8 M. When the Syk expression was knocked down by its shRNA, the inhibitory effects of ISL on activated macrophages disappeared, indicating that Syk was at least one of key docking‐molecules of ISL. Collectively, ISL could alleviate MCD‐induced NAFLD in mice involved with the inhibition of macrophage inflammatory activity by the blockade of Syk‐induced inflammasome activation.","PeriodicalId":21493,"journal":{"name":"Scandinavian Journal of Immunology","volume":"75 1","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140809678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Asymptomatic SARS‐CoV‐2 infection: A possible role of platelet HLA class I expression level 无症状 SARS-CoV-2 感染：血小板 HLA I 类表达水平的可能作用

IF 3.7 4区医学

Scandinavian Journal of Immunology Pub Date : 2024-04-08 DOI: 10.1111/sji.13370

Rocco Cantisani, Adriano Spreafico, Giuseppe Marotta

引用次数: 0