压力对 0-18 岁儿童接种疫苗后抗体反应的影响:系统综述。

IF 4.1 4区 医学 Q2 IMMUNOLOGY
Scandinavian Journal of Immunology Pub Date : 2024-08-01 Epub Date: 2024-06-24 DOI:10.1111/sji.13394
Rikke Svensson, Michelle Malon, Lone G Stensballe, Steffen U Thorsen, Jannet Svensson
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引用次数: 0

摘要

压力与成人较低的疫苗应答效率有关。本综述旨在研究儿童中存在类似关联的证据。2021 年 1 月,我们在三个数据库中进行了系统性综述检索:Medline、Embase 和 PsycInfo。对 Medline 数据库进行了系统性的更新搜索,直至 2023 年 9 月 25 日的最新更新,以确保纳入现有的最新研究。我们使用了与压力、疫苗和儿童相关的关键词,并由两名独立调查员筛选了共计 7263 项(+1528)研究。有六项研究符合数据提取和分析的纳入标准。在对研究进行质量评估时,采用了非随机干预研究偏倚风险(ROBINS-I)工具。大多数研究表明,压力对疫苗反应有负面影响。然而,由于研究数量稀少、缺乏确证研究、存在偏倚风险以及年龄、疫苗类型、压力测量和疫苗反应的异质性,因此无法得出明确的结论。未来的研究应强调使用尽可能严格的研究设计,包括明确定义的压力指标和对接种前和接种后反应的彻底检查。系统综述注册:Prospero CRD42021230490。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The effect of stress on the antibody response after vaccination in children aged 0-18 years: A systematic review.

Stress has been associated with less effective vaccine responses in adults. This review aims to investigate the evidence for a similar association in children. A systematic review search was conducted in January 2021 in three databases: Medline, Embase and PsycInfo. An updated search of the Medline database was systematically conducted until the most recent update on September 25th, 2023, to ensure the inclusion of the most current research available. Keywords related to stress, vaccines and children were used, and a total of 7263 (+1528) studies were screened by two independent investigators. Six studies met the inclusion criteria for data extraction and analysis. For quality assessment of the studies, the risk of bias in non-randomized studies-of interventions (ROBINS-I) tool was applied. Most of the studies suggest a negative role of stress on vaccine responses. However, the scarcity of studies, lack of confirmatory studies, risk of bias and heterogeneity according to age, type of vaccine, measures of stress and vaccine responses prevent a clear conclusion. Future studies should emphasize the use of as strict study designs as possible, including well-defined stress metrics and thorough examination of both pre- and post-vaccination responses. Systematic review registration: Prospero CRD42021230490.

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来源期刊
CiteScore
7.70
自引率
5.40%
发文量
109
审稿时长
1 months
期刊介绍: This peer-reviewed international journal publishes original articles and reviews on all aspects of basic, translational and clinical immunology. The journal aims to provide high quality service to authors, and high quality articles for readers. The journal accepts for publication material from investigators all over the world, which makes a significant contribution to basic, translational and clinical immunology.
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