Scandinavian Journal of Gastroenterology最新文献

筛选
英文 中文
Dietary intake and nutritional status in patients with newly diagnosed inflammatory bowel disease: insights from the IBSEN III study. 新诊断炎症性肠病患者的饮食摄入和营养状况:IBSEN III 研究的启示。
IF 1.9 4区 医学
Scandinavian Journal of Gastroenterology Pub Date : 2024-06-01 Epub Date: 2024-02-15 DOI: 10.1080/00365521.2024.2313056
Insaf Zerouga, Jørgen Valeur, Christine Sommer, Milada Cvancarova Småstuen, Asle Wilhelm Medhus, Charlotte Lund, Ingunn Johansen, Raziye Boyar Cetinkaya, May-Bente Bengtson, Roald Torp, Øistein Hovde, Gert Huppertz-Hauss, Trond Espen Detlie, Tone Bergene Aabrekk, Petr Ricanek, Svein Oskar Frigstad, Laila Arnesdatter Hopstock, Randi Opheim, Vendel Ailin Kristensen, Marte Lie Høivik, Monica Hauger Carlsen, Anne-Marie Aas
{"title":"Dietary intake and nutritional status in patients with newly diagnosed inflammatory bowel disease: insights from the IBSEN III study.","authors":"Insaf Zerouga, Jørgen Valeur, Christine Sommer, Milada Cvancarova Småstuen, Asle Wilhelm Medhus, Charlotte Lund, Ingunn Johansen, Raziye Boyar Cetinkaya, May-Bente Bengtson, Roald Torp, Øistein Hovde, Gert Huppertz-Hauss, Trond Espen Detlie, Tone Bergene Aabrekk, Petr Ricanek, Svein Oskar Frigstad, Laila Arnesdatter Hopstock, Randi Opheim, Vendel Ailin Kristensen, Marte Lie Høivik, Monica Hauger Carlsen, Anne-Marie Aas","doi":"10.1080/00365521.2024.2313056","DOIUrl":"10.1080/00365521.2024.2313056","url":null,"abstract":"<p><strong>Background: </strong>Dietary recommendations in inflammatory bowel disease (IBD) are inconclusive, and patients may follow restrictive diets with increased risk of malnutrition. The aim of this study was to compare dietary intakes and nutritional status in men and women with newly diagnosed IBD with a general population sample, and to investigate whether intakes were in line with the Nordic Nutrition Recommendations.</p><p><strong>Methods: </strong>This was a cross-sectional study including adults≥ 40 years with IBD from the Inflammatory Bowel Disease in South-Eastern Norway (IBSEN) III cohort study. A validated food frequency questionnaire (FFQ) was used in dietary data collection, and a sample from the seventh survey of the Tromsø Study was included as a comparison group.</p><p><strong>Results: </strong>A total of 227 men and women with IBD were included. IBD patients had higher intake of grain products, sweetened beverages, energy, fat and polyunsaturated fat (PUFA), but lower intake of dairy products, alcohol and iodine compared to adults from the comparison sample (<i>p</i> < 0.01). Intakes of saturated fat and carbohydrates in both genders, and vitamin D in women were not within recommended levels. Anemia and hypoalbuminemia were more prevalent in IBD patients than in the comparison sample.</p><p><strong>Conclusions: </strong>Dietary intakes in newly diagnosed IBD patients were mostly in line with Nordic Nutrition Recommendations. Higher proportion of IBD patients exceeded recommended allowances of fat and added sugar than the comparison sample. Insufficient micronutrient intake, anemia and hypoalbuminemia are present challenges in IBD patients that require monitoring.</p>","PeriodicalId":21461,"journal":{"name":"Scandinavian Journal of Gastroenterology","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139736056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Efficacy of optimised thiopurine therapy in patients with moderate-to-severe ulcerative colitis: retrospective long-term follow-up from two randomised trials. 优化硫嘌呤疗法对中重度溃疡性结肠炎患者的疗效:两项随机试验的回顾性长期随访。
IF 1.6 4区 医学
Scandinavian Journal of Gastroenterology Pub Date : 2024-06-01 Epub Date: 2024-03-05 DOI: 10.1080/00365521.2024.2323502
Anette Mertz Nielsen, Klaus Theede, Lise Lotte Gluud, Marianne Kiszka-Kanowitz
{"title":"Efficacy of optimised thiopurine therapy in patients with moderate-to-severe ulcerative colitis: retrospective long-term follow-up from two randomised trials.","authors":"Anette Mertz Nielsen, Klaus Theede, Lise Lotte Gluud, Marianne Kiszka-Kanowitz","doi":"10.1080/00365521.2024.2323502","DOIUrl":"10.1080/00365521.2024.2323502","url":null,"abstract":"<p><strong>Objective: </strong>The long-term outcome of thiopurine therapy in patients with ulcerative colitis (UC) enrolled in prospective trials have not been evaluated. We aimed to assess the effects of optimised thiopurine maintenance therapy for UC.</p><p><strong>Methods: </strong>Long-term data were obtained from patients from our center enrolled in two randomised, prospective, open-label, controlled studies comprising 66 thiopurine-naïve moderate-to-severe patients with UC consisting of a low dose azathioprine (AZA)/allopurinol combination or AZA monotherapy. Following the randomised trials, treatment was adjusted according to adverse effects and metabolites. Patients requiring optimisation initially on AZA monotherapy treatment were switched to low dose AZA in combination with allopurinol, low dose 6-mercaptopurin in combination with allopurinol, or 6-mercaptopurin treatment alone, and those treated with low dose AZA in combination with allopurinol were switched to low dose 6-mercaptopurin in combination with allopurinol or 6-mercaptopurin alone.</p><p><strong>Results: </strong>A total of 62 patients were included in the analysis; 31 were initially treated with AZA monotherapy and 31 with low dose AZA in combination with allopurinol. Initial treatment was tolerated by 67% patients (7 AZA monotherapy and 28 low dose AZA in combination with allopurinol), increasing to 94% (58 patients) post-adjustment. After a median 52-month follow-up period, 38 (93%) out of the 41 primary responding patients-maintained clinical remission without steroids, biologics or surgery. The four intolerant patients and the 17 not responding to optimisation were more likely to require colectomy (odds ratio 16.36; 95% confidence interval 3.08-87.03, <i>p</i> < 0.0001).</p><p><strong>Conclusion: </strong>Optimised thiopurine therapy demonstrated effective long-term treatment for patients with ulcerative colitis.</p>","PeriodicalId":21461,"journal":{"name":"Scandinavian Journal of Gastroenterology","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140040199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Intra-pancreatic fat deposition and its relation to obesity: a magnetic resonance imaging study. 胰腺内脂肪沉积及其与肥胖的关系:一项磁共振成像研究。
IF 1.9 4区 医学
Scandinavian Journal of Gastroenterology Pub Date : 2024-06-01 Epub Date: 2024-04-01 DOI: 10.1080/00365521.2024.2333365
Mimoza Gjela, Anders Askeland, Maiken Mellergaard, Asbjørn Mohr Drewes, Aase Handberg, Jens Brøndum Frøkjær
{"title":"Intra-pancreatic fat deposition and its relation to obesity: a magnetic resonance imaging study.","authors":"Mimoza Gjela, Anders Askeland, Maiken Mellergaard, Asbjørn Mohr Drewes, Aase Handberg, Jens Brøndum Frøkjær","doi":"10.1080/00365521.2024.2333365","DOIUrl":"10.1080/00365521.2024.2333365","url":null,"abstract":"<p><strong>Objectives: </strong>Intra-pancreatic fat deposition (IPFD) is suspected to be associated with various medical conditions. This study aimed to assess pancreatic fat content in lean and obese individuals, characterize obese individuals with and without IPFD, and explore the underlying mechanisms.</p><p><strong>Materials and methods: </strong>Sixty-two obese individuals without diabetes and 35 lean controls underwent magnetic resonance imaging (MRI) using proton density fat fraction (PDFF) maps to evaluate pancreatic and hepatic fat content, and visceral adipose tissue (VAT) content. Pancreatic fibrosis was explored by T1 relaxation time and MR elastography (MRE) measurements. Associations between pancreatic fat, measures of obesity and metabolic syndrome were examined using uni- and multivariate regression analyses.</p><p><strong>Results: </strong>Pancreatic PDFF was higher in obese than in lean controls (median 8.0%, interquartile range (6.1;13.3) % vs 2.6(1.7;3.9)%, <i>p</i> < 0.001). Obese individuals with IPFD (PDFF ≥6.2%) had higher waist circumference (114.0 ± 12.5 cm vs 105.2 ± 8.7 cm, <i>p</i> = 0.007) and VAT (224.9(142.1; 316.1) cm<sup>2</sup> vs 168.2(103.4; 195.3) cm<sup>2</sup>, <i>p</i> < 0.001) than those without. In univariate analysis, pancreatic PDFF in obese individuals correlated with BMI (<i>r</i> = 0.27, <i>p</i> = 0.03), waist circumference (<i>r</i> = 0.44, <i>p</i> < 0.001), VAT (<i>r</i> = 0.37, <i>p</i> = 0.004), hepatic PDFF (<i>r</i> = 0.25, <i>p</i> = 0.046) and diastolic blood pressure (<i>r</i> = 0.32, <i>p</i> = 0.01). However, in multivariate analysis, only VAT was associated to pancreatic fat content. MRI measures of pancreatic fibrosis indicated no evident fibrosis in relation to increased pancreatic fat content.</p><p><strong>Conclusions: </strong>Pancreatic fat content was increased in obese individuals compared with lean controls and predominantly correlated with the amount of visceral adipose tissue. Pancreatic fat content was not clearly linked to measures of pancreatic fibrosis.</p>","PeriodicalId":21461,"journal":{"name":"Scandinavian Journal of Gastroenterology","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140336765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Activin A levels in metabolic dysfunction-associated steatotic liver disease associates with fibrosis and the PNPLA3 I148M variant. 代谢功能障碍相关性脂肪性肝病中的活化素 A 水平与肝纤维化和 PNPLA3 I148M 变体有关。
IF 1.9 4区 医学
Scandinavian Journal of Gastroenterology Pub Date : 2024-06-01 Epub Date: 2024-04-02 DOI: 10.1080/00365521.2024.2334804
Cecilia Jönsson, Martin Bergram, Stergios Kechagias, Patrik Nasr, Mattias Ekstedt
{"title":"Activin A levels in metabolic dysfunction-associated steatotic liver disease associates with fibrosis and the PNPLA3 I148M variant.","authors":"Cecilia Jönsson, Martin Bergram, Stergios Kechagias, Patrik Nasr, Mattias Ekstedt","doi":"10.1080/00365521.2024.2334804","DOIUrl":"10.1080/00365521.2024.2334804","url":null,"abstract":"<p><strong>Background: </strong>Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most prevalent chronic liver condition worldwide. There is an urgent need to develop new biomarkers to assess disease severity and to define patients with a progressive phenotype. Activin A is a new promising biomarker with conflicting results about liver fibrosis. In this study we investigate levels of Activin A in patients with biopsy proven MASLD. We assess levels of Activin A in regard to fibrosis stage and genetic variant I148M in the patatin-like phospholipase domain-containing protein 3 (PNPLA3).</p><p><strong>Methods: </strong>Activin A levels were assessed in plasma samples from patients with biopsy-proven MASLD in a cross-sectional study. All patients were clinically evaluated and the <i>PNPLA3</i> I148M genotype of the cohort was assessed.</p><p><strong>Findings: </strong>41 patients were included and 27% of these had advanced fibrosis. In MASLD patients with advanced fibrosis, Activin A levels was higher (<i>p</i> < 0.001) and could classify advanced fibrosis with an AUROC for activin A of 0.836 (<i>p</i> < 0.001). Patients homozygous for <i>PNPLA3</i> I148M G/G had higher levels of activin A than non-homozygotes (<i>p</i> = 0.027).</p><p><strong>Conclusions: </strong>Circulating activin A levels were associated with advanced fibrosis and could be a potential blood biomarker for identifying advanced fibrosis in MASLD. Patients with the risk genotype <i>PNPLA3</i> I148M G/G had higher levels of activin A proposing activin A as a contributor of the transition from simple steatosis to a fibrotic phenotype.</p>","PeriodicalId":21461,"journal":{"name":"Scandinavian Journal of Gastroenterology","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140336764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Does the presence of an esophageal motor disorder influence the response to anti-reflux mucosectomy (ARMS) for refractory GERD? 食管运动障碍是否会影响抗反流粘液切除术(ARMS)治疗难治性胃食管反流病的效果?
IF 1.9 4区 医学
Scandinavian Journal of Gastroenterology Pub Date : 2024-06-01 Epub Date: 2024-03-18 DOI: 10.1080/00365521.2024.2331554
Philippe Onana Ndong, Jean-Michel Gonzalez, Ana Beyrne, Marc Barthet, Veronique Vitton
{"title":"Does the presence of an esophageal motor disorder influence the response to anti-reflux mucosectomy (ARMS) for refractory GERD?","authors":"Philippe Onana Ndong, Jean-Michel Gonzalez, Ana Beyrne, Marc Barthet, Veronique Vitton","doi":"10.1080/00365521.2024.2331554","DOIUrl":"10.1080/00365521.2024.2331554","url":null,"abstract":"<p><strong>Introduction: </strong>The prevalence of esophageal motor disorders (EMD) in PPI-refractory gastroesophageal reflux disease (GERD) is substantial. However, limited data exist on their impact on the efficacy of endoscopic treatments like anti-reflux mucosectomy (ARMS). This study aimed to evaluate the influence of EMD on ARMS efficacy in patients with PPI-refractory GERD.</p><p><strong>Method: </strong>This single-center retrospective study enrolled patients with refractory GERD treated with ARMS-b (anti-reflux mucosectomy band-ligation). High-resolution esophageal manometry (HREM) was conducted before the procedure to identify EMD presence. The primary endpoint was treatment efficacy, defined as >50% improvement in GERD-HRQL score at 1 year. Secondary endpoints included PPI intake, symptom control, ARMS complications, and overall patient satisfaction at 12 months.</p><p><strong>Results: </strong>The study included 65 patients, with 41 (63.1%) showing EMD on HREM. Treatment efficacy was achieved by 33.8% (22) of patients, with 8 without EMD, 11 having isolated LES hypotonia, and 3 with both LES hypotonia and esophageal body motor disorder. No significant differences were observed between patients with and without EMD regarding the primary endpoint, PPI use, symptom control, or complications. Dysphagia developed in 52.3% (34) within 6 months, leading to esophageal dilatation in 15.3% (10). Two patients experienced acute hemorrhage, and one had perforation.</p><p><strong>Conclusion: </strong>The presence of esophageal motor disorders does not seem to impact ARMS response, suggesting the technique's consideration in this population. Larger studies are essential for confirming these results and exploring treatment response and post-operative predictors.</p>","PeriodicalId":21461,"journal":{"name":"Scandinavian Journal of Gastroenterology","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140143990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Topical pharyngeal anesthesia with articaine for gastroscopy: a double-blinded, randomized cross-over study in healthy volunteers. 在胃镜检查中使用阿替卡因进行局部咽部麻醉:一项针对健康志愿者的双盲随机交叉研究。
IF 1.6 4区 医学
Scandinavian Journal of Gastroenterology Pub Date : 2024-06-01 Epub Date: 2024-03-05 DOI: 10.1080/00365521.2024.2323504
Niklas Mattila, Maxim Mazanikov, Marianne Udd, Leena Kylänpää, Outi Lindström, Pertti Pere, Reino Pöyhiä, Matti Ristikankare
{"title":"Topical pharyngeal anesthesia with articaine for gastroscopy: a double-blinded, randomized cross-over study in healthy volunteers.","authors":"Niklas Mattila, Maxim Mazanikov, Marianne Udd, Leena Kylänpää, Outi Lindström, Pertti Pere, Reino Pöyhiä, Matti Ristikankare","doi":"10.1080/00365521.2024.2323504","DOIUrl":"10.1080/00365521.2024.2323504","url":null,"abstract":"<p><strong>Objectives: </strong>The benefits of topical pharyngeal anesthesia for gastroscopy remain under debate. Articaine, a local anesthetic with fast onset and offset of action as well as low systemic toxicity, could be a promising choice for topical anesthesia. The objective of this study was to assess whether topical pharyngeal anesthesia with articaine is beneficial in sedated gastroscopy.</p><p><strong>Materials and methods: </strong>This randomized double-blinded cross-over study included nine volunteers who underwent two gastroscopies under conscious sedation. One was performed with topical pharyngeal anesthesia with articaine and the other with placebo. Hemodynamic parameters including autonomic nervous system state were recorded prior to and during the endoscopic procedure. The endoscopist and the volunteer assessed the endoscopy after the examination.</p><p><strong>Results: </strong>Topical pharyngeal anesthesia with articaine resulted in less discomfort during esophageal intubation and higher patient satisfaction with the procedure. Topical pharyngeal anesthesia with articaine did not increase satisfaction or facilitate the procedure as rated by the endoscopist. There were no clinically relevant differences in hemodynamic parameters.</p><p><strong>Conclusion: </strong>The use of articaine for topical pharyngeal anesthesia results in less intubation-related discomfort and better satisfaction.</p>","PeriodicalId":21461,"journal":{"name":"Scandinavian Journal of Gastroenterology","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140028829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The lncRNA TRG-AS1 promotes the growth of colorectal cancer cells through the regulation of P2RY10/GNA13. lncRNA TRG-AS1通过调控P2RY10/GNA13促进结直肠癌细胞的生长。
IF 1.9 4区 医学
Scandinavian Journal of Gastroenterology Pub Date : 2024-06-01 Epub Date: 2024-02-15 DOI: 10.1080/00365521.2024.2318363
Longqing Shi, Baoyang Luo, Linghui Deng, Qi Zhang, Yuanjiu Li, Donglin Sun, Hua Zhang, Lin Zhuang
{"title":"The lncRNA TRG-AS1 promotes the growth of colorectal cancer cells through the regulation of P2RY10/GNA13.","authors":"Longqing Shi, Baoyang Luo, Linghui Deng, Qi Zhang, Yuanjiu Li, Donglin Sun, Hua Zhang, Lin Zhuang","doi":"10.1080/00365521.2024.2318363","DOIUrl":"10.1080/00365521.2024.2318363","url":null,"abstract":"<p><strong>Background: </strong>The lncRNA TRG-AS1 and its co-expressed gene P2RY10 are important for colorectal cancer (CRC) occurrence and development. The purpose of our research was to explore the roles of TRG-AS1 and P2RY10 in CRC progression.</p><p><strong>Methods: </strong>The abundance of TRG-AS1 and P2RY10 in CRC cell lines (HT-29 and LoVo) and normal colon cells FHC was determined and difference between CRC cells and normal cells was compared. LoVo cells were transfected with si-TRG-AS1 and si-P2RY10 constructs. Subsequently, the viability, colony formation, and migration of the transfected cells were analyzed using cell counting kit-8, clonogenicity, and scratch-wound/Transwell® assays, respectively. Cells overexpressing GNA13 were used to further explore the relationship between TRG-AS1 and P2RY10 along with their downstream functions. Finally, nude mice were injected with different transfected cell types to observe tumor formation <i>in vivo</i>.</p><p><strong>Results: </strong>TRG-AS1 and P2RY10 were significantly upregulated in HT-29 and LoVo compared to FHC cells. TRG-AS1 knockdown and P2RY10 silencing suppressed the viability, colony formation, and migration of LoVo cells. TRG-AS1 knockdown downregulated the expression of P2RY10, GNA12, and GNA13, while P2RY10 silencing downregulated the expression of TRG-AS1, GNA12, and GNA13. Additionally, GNA13 overexpression reversed the cell growth and gene expression changes in LoVo cells induced by TRG-AS1 knockdown or P2RY10 silencing. <i>In vivo</i> experiments revealed that CRC tumor growth was suppressed by TRG-AS1 knockdown and P2RY10 silencing.</p><p><strong>Conclusions: </strong>TRG-AS1 knockdown repressed the growth of HT-29 and LoVo by regulating P2RY10 and GNA13 expression.</p>","PeriodicalId":21461,"journal":{"name":"Scandinavian Journal of Gastroenterology","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139736057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Substantial cost savings of ultrasound-based management over magnetic resonance imaging-based management in an inflammatory bowel disease service. 在炎症性肠病服务中,超声波管理比磁共振成像管理节省大量成本。
IF 1.9 4区 医学
Scandinavian Journal of Gastroenterology Pub Date : 2024-06-01 Epub Date: 2024-03-19 DOI: 10.1080/00365521.2024.2330588
Shellie J Radford, Buraq Abdul-Aema, Chris Tench, Paul Leighton, Jane Coad, Gordon W Moran
{"title":"Substantial cost savings of ultrasound-based management over magnetic resonance imaging-based management in an inflammatory bowel disease service.","authors":"Shellie J Radford, Buraq Abdul-Aema, Chris Tench, Paul Leighton, Jane Coad, Gordon W Moran","doi":"10.1080/00365521.2024.2330588","DOIUrl":"10.1080/00365521.2024.2330588","url":null,"abstract":"<p><strong>Background: </strong>Imaging is used to monitor disease activity in small bowel Crohn's disease (CD). Magnetic Resonance Enterography is often employed as a first modality in the United Kingdom for assessment and monitoring; however, waiting times, cost, patient burden and limited access are significant. It is as yet uncertain if small bowel intestinal ultrasound (IUS) may be a quicker, more acceptable, and cheaper alternative for monitoring patients with CD.</p><p><strong>Methods: </strong>A clinical service evaluation of imaging pathways was undertaken at a single NHS site in England, United Kingdom. Data were collected about patients who were referred and underwent an imaging analysis for their IBD. Only patients who underwent a therapy change were included in the analysis. Data were collected from care episodes between 01 January 2021-30 March 2022.</p><p><strong>Results: </strong>A combined total of 193 patient care episodes were reviewed, 107 from the IUS pathway and 86 from the MRE pathway. Estimated costs per patient in the IUS pathway was £78.86, and £375.35 per patient in the MRE pathway. The MRE pathway had an average time from referral to treatment initiation of 91 days (SD= ±61) with patients in the IUS pathway waiting an average of 46 days (SD= ±17).</p><p><strong>Conclusions: </strong>Findings from this work indicate that IUS is a potential cost-saving option when compared to MRE when used in the management of CD. This is in addition to the cost difference of the radiological modalities. A large, multicentre, prospective study is needed to validate these initial findings.</p>","PeriodicalId":21461,"journal":{"name":"Scandinavian Journal of Gastroenterology","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140158957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Plasma bile acids in association with Crohn's disease. 血浆胆汁酸与克罗恩病的关系。
IF 1.9 4区 医学
Scandinavian Journal of Gastroenterology Pub Date : 2024-06-01 Epub Date: 2024-03-20 DOI: 10.1080/00365521.2024.2328592
Ali Kiasat, Stefanie Prast-Nielsen, Susanne Rautiainen, Lars Engstrand, Fredrik Andersson, Johan Lindberg, Ina Schuppe-Koistinen, Anna Löf Granström, Ulf O Gustafsson
{"title":"Plasma bile acids in association with Crohn's disease.","authors":"Ali Kiasat, Stefanie Prast-Nielsen, Susanne Rautiainen, Lars Engstrand, Fredrik Andersson, Johan Lindberg, Ina Schuppe-Koistinen, Anna Löf Granström, Ulf O Gustafsson","doi":"10.1080/00365521.2024.2328592","DOIUrl":"10.1080/00365521.2024.2328592","url":null,"abstract":"<p><strong>Background: </strong>In addition to facilitating lipid digestions, bile acids (BA) are signalling molecules acting on receptors on immune cells and along the gastrointestinal (GI) tract. The aim of this study was to assess if altered bile acid profiles in plasma are associated with Crohn's disease (CD).</p><p><strong>Method: </strong>This cross-sectional study included individuals (aged ≥18 years) referred for colonoscopy at a tertiary centre in Stockholm between 2016 and 2019. All participants received bowel preparation, completed a lifestyle questionnaire and provided blood samples for analysis. During colonoscopy, severity of disease was graded, and biopsies were taken from colonic mucosa. In the current substudy, 88 individuals with CD and 88 age-matched controls were selected for analysis of BA in plasma with ultra performance liquid chromatography (UPLC). Linear regression models were then used to compare mean bile acid concentrations and concentration ratios between CD and controls.</p><p><strong>Results: </strong>Individuals with CD had lower plasma concentrations of the majority of secondary BA compared to controls, in total CD/CC ratio 0.60 (SE 0.12), <i>p</i> = 0.001. The most prominent observations were lower levels of deoxycolic acid derivates and lithocolic acid derivates among participants with CD. Moreover, plasma concentration for secondary BA among participants with active CD was significantly lower compared to those with CD in remission, CD active/CD remission ratio 0.65 (SE 0.11), <i>p</i> < 0.002.</p><p><strong>Conclusion: </strong>Crohn's disease may be associated with altered plasma bile acid composition. The significance of colonic bacterial diversity in this context needs to be investigated in further studies.</p>","PeriodicalId":21461,"journal":{"name":"Scandinavian Journal of Gastroenterology","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140176270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluation of the role of body mass index (BMI) in the association between dietary inflammatory index and non-alcoholic fatty liver diseases: a letter to editor. 评估体重指数(BMI)在膳食炎症指数与非酒精性脂肪肝之间关系中的作用:致编辑的一封信。
IF 1.6 4区 医学
Scandinavian Journal of Gastroenterology Pub Date : 2024-06-01 Epub Date: 2024-02-28 DOI: 10.1080/00365521.2024.2323513
Matin Sepehrinia, Hossein Pourmontaseri
{"title":"Evaluation of the role of body mass index (BMI) in the association between dietary inflammatory index and non-alcoholic fatty liver diseases: a letter to editor.","authors":"Matin Sepehrinia, Hossein Pourmontaseri","doi":"10.1080/00365521.2024.2323513","DOIUrl":"10.1080/00365521.2024.2323513","url":null,"abstract":"","PeriodicalId":21461,"journal":{"name":"Scandinavian Journal of Gastroenterology","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139983713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信