Scandinavian Journal of Gastroenterology最新文献

Nonlinear association between serum selenium and all-cause mortality in U.S. adults with NAFLD: a cohort study. 美国NAFLD成人血清硒与全因死亡率之间的非线性关系：一项队列研究。

IF 1.8 4区医学

Scandinavian Journal of Gastroenterology Pub Date : 2026-09-01 Epub Date: 2026-05-30 DOI: 10.1080/00365521.2026.2679098

Yudong Ma, Xingxing Chai, Wei Wu, Dezhi Gu, Ping Yi, Zhengdong Wang, Wanchuan Zhuang

{"title":"Nonlinear association between serum selenium and all-cause mortality in U.S. adults with NAFLD: a cohort study.","authors":"Yudong Ma, Xingxing Chai, Wei Wu, Dezhi Gu, Ping Yi, Zhengdong Wang, Wanchuan Zhuang","doi":"10.1080/00365521.2026.2679098","DOIUrl":"10.1080/00365521.2026.2679098","url":null,"abstract":"Background: Selenium, an essential trace element, modulates oxidative stress and inflammation-key factors in non-alcoholic fatty liver disease (NAFLD) progression. This study explores the relationship between serum selenium and all-cause mortality in NAFLD patients, a group vulnerable to oxidative damage.Methods: We analyzed data from 9,254 NHANES 2017-2018 participants. After excluding those without NAFLD (n = 7,136) and missing selenium/mortality data (n = 331), 1,787 NAFLD patients were included. Serum selenium was categorized into quartiles (Q1-Q4: 104.73-376.80 μg/L). Cox proportional hazards models estimated hazard ratios (HRs) with adjustments for demographics, lifestyle, comorbidities and biomarkers. Restricted cubic spline (RCS) and Kaplan-Meier analyses assessed dose-response relationships and survival differences. Subgroup analyses examined effects by age, sex and comorbidities.Results: Among 1,787 NAFLD adults, multivariable analysis showed a significant inverse association between serum selenium and all-cause mortality. Participants in the highest selenium quartile (Q4: 204.39-376.80 μg/L) had a 64% lower mortality risk compared to the lowest quartile (Q1) after full adjustment (HR = 0.36, 95% CI: 0.13-0.99, p < 0.05). RCS analysis confirmed a nonlinear dose-response, with mortality risk plateauing at selenium levels >200 μg/L. Subgroup analyses suggested greater protection in older adults (≥60) and hypertensive individuals (p < 0.05), though formal interaction tests were nonsignificant (p > 0.05).Conclusion: Moderate selenium levels are associated with reduced all-cause mortality in NAFLD, particularly in older adults. These findings highlight selenium's potential in lowering mortality risk in metabolic disease populations, though further research is needed to clarify its role in NAFLD progression.","PeriodicalId":21461,"journal":{"name":"Scandinavian Journal of Gastroenterology","volume":" ","pages":"964-975"},"PeriodicalIF":1.8,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148101830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fibroblast activation protein and down-stream effects on its substrates in metabolic dysfunction-associated steatotic liver disease. 成纤维细胞激活蛋白及其底物在代谢功能障碍相关的脂肪变性肝病中的下游作用

IF 1.8 4区医学

Scandinavian Journal of Gastroenterology Pub Date : 2026-09-01 Epub Date: 2026-06-03 DOI: 10.1080/00365521.2026.2679101

Sara F Hansson, Patrik Nasr, Jane Knöchel, Tasso Miliotis, Anne-Christine Andréasson, Andreas Hober, Ann-Christin Nyström, Linnéa Bergenholm, Mahssa Karimi, Xiao-Rong Peng, Mattias Ekstedt, Stergios Kechagias, Mathias Liljeblad

{"title":"Fibroblast activation protein and down-stream effects on its substrates in metabolic dysfunction-associated steatotic liver disease.","authors":"Sara F Hansson, Patrik Nasr, Jane Knöchel, Tasso Miliotis, Anne-Christine Andréasson, Andreas Hober, Ann-Christin Nyström, Linnéa Bergenholm, Mahssa Karimi, Xiao-Rong Peng, Mattias Ekstedt, Stergios Kechagias, Mathias Liljeblad","doi":"10.1080/00365521.2026.2679101","DOIUrl":"10.1080/00365521.2026.2679101","url":null,"abstract":"Background: Fibroblast activation protein (FAP) is a serine protease upregulated in liver and blood in patients with chronic liver disease of several etiologies. FAP has a pro-fibrotic effect and may also regulate disease progression by proteolytically affecting two circulating substrates, fibroblast growth factor 21 (FGF21) and α2-antiplasmin (α2AP). The aim of this study was to investigate the involvement of FAP in metabolic dysfunction-associated steatotic liver disease (MASLD).Methods: FAP protein levels were measured in liver biopsies (n = 47) and plasma samples (n = 79) from an extensively characterized longitudinal MASLD cohort. FAP-cleaved and -uncleaved forms of α2AP were measured with a novel mass spectrometry-based method, using isotopically labeled recombinant protein fragments as internal standards. Total and intact FGF21 levels were quantified using ELISA. Results were correlated to histopathological steatosis grade, inflammation grade, ballooning grade and fibrosis stage.Results: Both liver and plasma levels of FAP were increased in patients with advanced fibrosis, stage 3-4 vs 0-2 (p < 0.005) but were not affected by steatosis grade. The fraction of FAP-cleaved α2AP correlated with the plasma FAP level and was significantly higher in patients with fibrosis stage 3-4 (p < 0.05). In contrast, plasma FAP did not correlate with the ratio of intact FGF21.Conclusion: These results show that FAP expression is increased in more advanced hepatic fibrosis. This suggests that FAP might be involved in the pathophysiology of MASLD progression and could be a biomarker for advanced hepatic fibrosis. Studies in larger prospective cohorts are needed to confirm these findings.","PeriodicalId":21461,"journal":{"name":"Scandinavian Journal of Gastroenterology","volume":" ","pages":"976-987"},"PeriodicalIF":1.8,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148151009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Supra-papillary versus trans-papillary stenting for malignant biliary obstruction: an updated meta-analysis of randomized trials. 恶性胆道梗阻的乳头上支架与经乳头支架：随机试验的最新荟萃分析。

IF 1.8 4区医学

Scandinavian Journal of Gastroenterology Pub Date : 2026-09-01 Epub Date: 2026-06-30 DOI: 10.1080/00365521.2026.2694745

Otavio Cosendey Martins, Vanio Antunes, Cynthia Florêncio de Mesquita, Tulio L Correa, Natália Junkes Milioli, Matheus Vanzin Fernandes, Stefano Baraldo, Babu P Mohan, Douglas G Adler

{"title":"Supra-papillary versus trans-papillary stenting for malignant biliary obstruction: an updated meta-analysis of randomized trials.","authors":"Otavio Cosendey Martins, Vanio Antunes, Cynthia Florêncio de Mesquita, Tulio L Correa, Natália Junkes Milioli, Matheus Vanzin Fernandes, Stefano Baraldo, Babu P Mohan, Douglas G Adler","doi":"10.1080/00365521.2026.2694745","DOIUrl":"10.1080/00365521.2026.2694745","url":null,"abstract":"Background: Malignant biliary obstruction (MBO) encompasses a variety of malignant obstructions of the extrahepatic biliary tree. The relatively common occurrence of duodenobiliary reflux (DBR) in patients with standard transpapillary stent placement for palliative management raises the importance of the development of alternative methods to prevent adverse outcomes.Aims: To compare supra-papillary to trans-papillary stenting in patients with MBO for stent dysfunction and adverse events.Methods: PubMed, Embase, and Cochrane were systematically searched for randomized trials. Outcomes assessed included stent occlusion, stent migration, cholangitis, stent patency duration, and overall survival. Statistical analyses were conducted using R (version 4.3.1) and a random-effects model was employed.Results: We found 3 randomized trials with 161 patients (80 in the supra-papilla stent group vs. 81 in the trans-papilla group). Supra-papillary stent placement was associated with significantly lower rates of stent occlusion (RR 0.76; 95% CI 0.59 to 0.97; p = 0.027), and longer cumulative duration of stent patency (MD 65.29; 95% CI 4.87 to 125.71; p = 0.03). The analyses of stent migration (p = 0.473), occurrence of cholangitis (p = 0.519), and patient survival (95% CI -1.64 to 179.38; p = 0.05) revealed no significant differences.Conclusion: We found a significant improvement in stent occlusion rates and cumulative duration of stent patency favoring the supra-papilla group, with no difference for stent migration, occurrence of cholangitis, and patient survival for this comparison.","PeriodicalId":21461,"journal":{"name":"Scandinavian Journal of Gastroenterology","volume":" ","pages":"934-937"},"PeriodicalIF":1.8,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148353658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A call for caution in expanding the mutational spectrum of SI gene deficiency. 扩大SI基因缺陷突变谱需谨慎。

IF 1.8 4区医学

Scandinavian Journal of Gastroenterology Pub Date : 2026-09-01 Epub Date: 2026-06-01 DOI: 10.1080/00365521.2026.2681103

Zuzana Spurná, Miroslav Fišer, Milan Macek, Martin Schwarz

{"title":"A call for caution in expanding the mutational spectrum of SI gene deficiency.","authors":"Zuzana Spurná, Miroslav Fišer, Milan Macek, Martin Schwarz","doi":"10.1080/00365521.2026.2681103","DOIUrl":"10.1080/00365521.2026.2681103","url":null,"abstract":"Background: Genetic sucrase-isomaltase deficiency (GSID) is increasingly recognized as a potentially underdiagnosed cause of chronic gastrointestinal symptoms in both children and adults. Once considered a rare autosomal recessive disorder with early, severe presentation, it is now understood to encompass a broader clinical spectrum, including milder and later-onset phenotypes that may overlap with irritable bowel syndrome.Methods: This commentary reviews recent advances in next-generation sequencing and current evidence on pathogenic SI gene variants, molecular mechanisms, genotype-phenotype relationships, and challenges in clinical interpretation.Results: Advances in genomic sequencing have facilitated increased identification of pathogenic SI variants associated with GSID. However, interpretation remains challenging due to variable penetrance and expressivity, with dominant-negative effects also considered possible. Additional challenges include inconsistent variant terminology, limited genotype-phenotype correlation, and heterogeneous functional data, all of which complicate diagnosis and prevalence estimation.Conclusion: Careful molecular interpretation, structured clinical assessment, and standardized terminology are needed to improve diagnosis and guide management across the full spectrum of GSID severity.","PeriodicalId":21461,"journal":{"name":"Scandinavian Journal of Gastroenterology","volume":" ","pages":"916-921"},"PeriodicalIF":1.8,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148138824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Objective acid exposure links to cardiac polyps: insights from 24-hour MII-pH monitoring and esophageal manometry. 目的：酸暴露与心脏息肉有关：24小时MII-pH监测和食管压力测量的见解。

IF 1.8 4区医学

Scandinavian Journal of Gastroenterology Pub Date : 2026-09-01 Epub Date: 2026-06-05 DOI: 10.1080/00365521.2026.2683202

Rong Rong Chen, Bang Jie Liu, Huan Yu Zhang, Zhang Yu Wang, Wei Ming Xiao, Yao Yao Li, Yan Bing Ding, Ke Yan Wu

{"title":"Objective acid exposure links to cardiac polyps: insights from 24-hour MII-pH monitoring and esophageal manometry.","authors":"Rong Rong Chen, Bang Jie Liu, Huan Yu Zhang, Zhang Yu Wang, Wei Ming Xiao, Yao Yao Li, Yan Bing Ding, Ke Yan Wu","doi":"10.1080/00365521.2026.2683202","DOIUrl":"10.1080/00365521.2026.2683202","url":null,"abstract":"Aim: The etiology of cardiac polyps remains debated. Previous studies have primarily relied on symptomatic and endoscopic findings, lacking objective evidence of gastroesophageal reflux. We aimed to investigate the relationship between pathologic acid exposure and cardiac polyps based on 24-hour multichannel intraluminal impedance-pH monitoring (24h MII-pH) and high-resolution esophageal manometry (HREM).Methods: This retrospective cross-sectional study enrolled patients who underwent upper endoscopy, 24h MII-pH and HREM examination. Clinical, endoscopic, and physiological parameters were compared between cardiac polyp and control group. Logistic regression was used to analyze the association between acid exposure time and cardiac polyps.Results: A total of 123 patients (37 in the polyp group, 86 in the control group) were included. Acid exposure time were significantly elevated, while lower esophageal sphincter resting pressure was lower in the polyp group. After adjusting for confounders, each 1% increase in acid exposure time was associated with a 25% higher risk of cardiac polyps. Patients with acid exposure time >6% had a 3.7-fold increased risk compared to those with acid exposure time <4%. Pathological acid exposure was associated with cardiac polyps in populations with low LES resting pressure and without H. pylori infection.Conclusion: This study is the first to objectively demonstrate an independent positive correlation between acid exposure time and cardiac polyps particularly in H. pylori-negative patients and those with esophageal motility disorders, but causal relationships cannot be established. These findings provide new insights into the pathogenesis of cardiac polyps and suggest a potential role for acid-suppressive therapy in selected patients.","PeriodicalId":21461,"journal":{"name":"Scandinavian Journal of Gastroenterology","volume":" ","pages":"1007-1016"},"PeriodicalIF":1.8,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148176537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Factors associated with mesalamine refractory ulcerative proctitis requiring advanced medical treatments. 美沙拉胺难治性溃疡性直肠炎相关因素需要先进的医学治疗。

IF 1.8 4区医学

Scandinavian Journal of Gastroenterology Pub Date : 2026-09-01 Epub Date: 2026-06-03 DOI: 10.1080/00365521.2026.2680169

Tom Borkovsky, Nathaniel Aviv Cohen, Ori Shoam, Lian Bannon, Ayal Hirsch, Yulia Ron, Tamar Thurm, Nitsan Maharshak, Haim Leibovitzh

{"title":"Factors associated with mesalamine refractory ulcerative proctitis requiring advanced medical treatments.","authors":"Tom Borkovsky, Nathaniel Aviv Cohen, Ori Shoam, Lian Bannon, Ayal Hirsch, Yulia Ron, Tamar Thurm, Nitsan Maharshak, Haim Leibovitzh","doi":"10.1080/00365521.2026.2680169","DOIUrl":"10.1080/00365521.2026.2680169","url":null,"abstract":"Background: Ulcerative proctitis (UP) is a subtype of ulcerative colitis (UC) affecting the rectum, usually manageable with mesalamine. However, a subgroup of patients is refractory to mesalamine, necessitating advanced therapies. We aimed to assess risk factors for refractory disease.Materials and methods: Data on proctitis patients were collected retrospectively from a single tertiary center during 2010-2024. Proctitis was defined as maximal disease extent of 20 cm from the anal verge. Patients treated with immunomodulators and/or biological therapy were considered to have refractory proctitis. Multivariable logistic regression analysis was used to identify risk factors.Results: We included 230 patients in the analysis, of whom 50 (21.7%) patients had refractory disease. At diagnosis, refractory patients were younger (25.0 years [20.0-32.0] vs. 30.5 years [22.5-41.0], p = 0.008), had longer disease extent (12.37 cm ± 5.81 vs. 9.87 cm ± 5.40, p = 0.018), had more severe endoscopic activity (Mayo endoscopic score [MES] 2/3: 21 [87.5%] vs. 45 [59.2%], p = 0.025) and more often used rectal steroids (24 [48.9%] vs. 31 [17.3%], p = 0.009). There was no difference between groups in sex, BMI, smoking status, presence of cecal patch, use of rectal 5-ASA or follow-up duration. In the multivariable regression model, the only significant predictors were use of topical steroids (odds ratio 4.0, 95% CI 1.13-14.13, p = 0.031) and baseline endoscopic severity (odds ratio 5.23, 95% CI 1.04-26.27, p = 0.044).Conclusions: The use of topical steroids and endoscopic disease severity at diagnosis were associated with refractory proctitis. These results may help stratify patients who could benefit from closer, tailored monitoring strategies.","PeriodicalId":21461,"journal":{"name":"Scandinavian Journal of Gastroenterology","volume":" ","pages":"956-963"},"PeriodicalIF":1.8,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148157523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Efficacy and safety of cold snare and hot snare endoscopic mucosal resection in the removal of colorectal polyps: a systematic review and meta-analysis based on RCT studies. 冷圈套和热圈套内镜下粘膜切除术切除结肠直肠息肉的疗效和安全性：基于RCT研究的系统回顾和荟萃分析。

IF 1.8 4区医学

Scandinavian Journal of Gastroenterology Pub Date : 2026-09-01 Epub Date: 2026-07-23 DOI: 10.1080/00365521.2026.2694743

Yihang Liu, Yuqing Lu, Kejia Liu, Jiong Zhang, Li Zheng, Chaoyang Wang

{"title":"Efficacy and safety of cold snare and hot snare endoscopic mucosal resection in the removal of colorectal polyps: a systematic review and meta-analysis based on RCT studies.","authors":"Yihang Liu, Yuqing Lu, Kejia Liu, Jiong Zhang, Li Zheng, Chaoyang Wang","doi":"10.1080/00365521.2026.2694743","DOIUrl":"10.1080/00365521.2026.2694743","url":null,"abstract":"Objective: To compare the efficacy and safety of cold snare endoscopic mucosal resection (C-EMR) and hot snare endoscopic mucosal resection (H-EMR) for colorectal polyps.Methods: PubMed, Embase, Cochrane Library and Scopus were systematically searched for randomized controlled trials (RCTs) published from database inception to March 15, 2026. Data were extracted independently by two investigators, and methodological quality was assessed using the Cochrane Risk of Bias tool. All outcomes were pooled with a random-effects model via RevMan software.Results: Eight RCTs involving 1466 patients were included. Overall procedural time showed no significant difference between groups (MD = -2.30 min, 95% CI: -8.69 to 4.09, p = 0.48). Subgroup analysis revealed C-EMR significantly shortened procedural time for polyps ≤20 mm (MD = -11.53 min, p = 0.004), while H-EMR was faster for polyps >20 mm (MD = 3.89 min, p < 0.001; subgroup interaction p < 0.001). No significant differences were found in complete resection, en bloc resection, technical success or intraprocedural bleeding rates. C-EMR had a trend toward higher postoperative recurrence, approaching significance in polyps >20 mm (p = 0.08). For safety, C-EMR had significantly lower risks of perforation (RR = 0.11, p = 0.01) and delayed bleeding (RR = 0.46, p = 0.02). .Conclusion: C-EMR features shorter procedural time and better safety for colorectal polyps ≤20 mm, whereas H-EMR is more suitable for polyps >20 mm. Including two landmark 2025 multicenter RCTs, this meta-analysis provides the latest evidence for individualized selection of resection techniques.","PeriodicalId":21461,"journal":{"name":"Scandinavian Journal of Gastroenterology","volume":" ","pages":"922-933"},"PeriodicalIF":1.8,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148562869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Introduction of a novel capsule sponge device for Barrett's surveillance - A Swedish multicenter feasibility study. 介绍一种用于巴雷特监测的新型胶囊海绵装置-瑞典多中心可行性研究。

IF 1.8 4区医学

Scandinavian Journal of Gastroenterology Pub Date : 2026-09-01 Epub Date: 2026-06-04 DOI: 10.1080/00365521.2026.2679097

P Löfdahl, P Elbe, A Thorell, M Jeremiasen, T Franzen, S L Haas, C Biörserud, S O Bratlie

{"title":"Introduction of a novel capsule sponge device for Barrett's surveillance - A Swedish multicenter feasibility study.","authors":"P Löfdahl, P Elbe, A Thorell, M Jeremiasen, T Franzen, S L Haas, C Biörserud, S O Bratlie","doi":"10.1080/00365521.2026.2679097","DOIUrl":"10.1080/00365521.2026.2679097","url":null,"abstract":"Background and study aims: Barrett's esophagus (BE) surveillance relies on endoscopy, which can limit accessibility and strain healthcare resources, a challenge in Nordic countries. Non-endoscopic alternatives could improve surveillance efficiency, but implementation data are limited. We assessed the feasibility of implementing EndoSign®, a novel capsule sponge, in Sweden.Patients and methods: This prospective, multicenter feasibility study across five Swedish hospitals (Dec 2023-Oct 2024), recruited 70 adults with histologically-confirmed BE undergoing routine surveillance. Trained nurses performed the capsule sponge procedure, with samples analyzed centrally for TFF3, atypia and p53. Feasibility objectives were technical success, patient acceptability and safety. We also assessed sample adequacy and risk stratification.Results: Of 70 enrolled patients (median age 68 years [IQR 63-72]; 84.3% male), 68 (97.1%) completed the procedure successfully. Patient acceptability was high; median discomfort was 2/10 [IQR 1-3] during the procedure, decreasing to 0/10 [IQR 0-1] after 15 min. Most patients (71.4%) preferred the capsule sponge over gastroscopy. Minor adverse events (sore throat) were present in three patients (4.3%) at 7 days and one patient (1.4%) at 90 days; no serious adverse events were reported. Sample adequacy was 92.6% (63/68). Risk stratification (n = 60) categorized 20.0% as high-risk, leading to expedited endoscopy.Conclusions: This capsule sponge demonstrated successful implementation with high technical success, patient acceptability and safety. The nurse-led delivery model proved effective, supporting potential broader implementation. This technology could provide a viable, patient-centered component of BE surveillance, though larger validation studies are needed.ClinicalTrials.gov Identifier: NCT07036432.","PeriodicalId":21461,"journal":{"name":"Scandinavian Journal of Gastroenterology","volume":" ","pages":"998-1006"},"PeriodicalIF":1.8,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148157508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A PEth-based assessment of alcohol relapse and predictors after liver transplantation for alcohol-related liver disease. 基于peth的酒精相关性肝病肝移植后酒精复发及预测因素评估

IF 1.8 4区医学

Scandinavian Journal of Gastroenterology Pub Date : 2026-09-01 Epub Date: 2026-06-11 DOI: 10.1080/00365521.2026.2685027

Eneli Katunin, Arno Nordin, Fredrik Åberg

{"title":"A PEth-based assessment of alcohol relapse and predictors after liver transplantation for alcohol-related liver disease.","authors":"Eneli Katunin, Arno Nordin, Fredrik Åberg","doi":"10.1080/00365521.2026.2685027","DOIUrl":"10.1080/00365521.2026.2685027","url":null,"abstract":"Background and aims: Alcohol-related liver disease (ALD) is a major indication for liver transplantation (LT) and post-LT alcohol relapses remain a key concern. We evaluated the risk and predictors in a nationwide ALD cohort using phosphatidylethanol (PEth), a direct biomarker of alcohol consumption.Methods: We retrospectively analyzed all adults transplanted for ALD in Finland 2018-2023. Alcohol relapse was defined as any relapse (PEth ≥ 0.03 µmol/L) or severe relapse (PEth ≥ 0.30 µmol/L). Cumulative incidence was estimated using competing-risk time-to-event methods, and predictors were examined using univariable Cox proportional hazards models.Results: Among 95 patients (median post-LT follow-up 4.3 years), 29 (31%) experienced any relapse and 13 of those (14%) severe relapse. Limited social support (HR 2.81, 95% CI 1.32-5.95) and insufficient assessment of alcohol use disorder (AUD) (HR 2.93, 95% CI 1.34-6.41) were associated with increased risk of any relapse, while involvement of a relative during LT evaluation (HR 0.28, 95% CI 0.10-0.72) and a formal diagnosis of alcohol dependence (HR 0.15, 95% CI 0.03-0.76) were protective. Older age reduced the risk of severe relapse (HR 0.93 per year, 95% CI 0.88-0.99). Among those transplanted within ≤6 months of pre-transplant abstinence (n = 9), 78% experienced any relapse and 44% developed severe relapse.Conclusion: In this national Finnish ALD cohort, approximately one third of LT recipients experienced alcohol relapse. Short pre-transplant abstinence and indicators of limited support and suboptimal AUD assessment were associated with higher relapse risk, underscoring the need for sustained addiction treatment and consistent support post-LT.","PeriodicalId":21461,"journal":{"name":"Scandinavian Journal of Gastroenterology","volume":" ","pages":"988-997"},"PeriodicalIF":1.8,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148219444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hepatitis C treatment uptake among incarcerated people in Norway, 2018-2019. 2018-2019年挪威服刑人员丙型肝炎治疗情况

IF 1.8 4区医学

Scandinavian Journal of Gastroenterology Pub Date : 2026-09-01 Epub Date: 2026-06-12 DOI: 10.1080/00365521.2026.2685826

Eirik Opheim, Anette Fredriksen, Joakim Hauge, Olav Dalgard, Kristian Braathen Malme, Håvard Midgard

{"title":"Hepatitis C treatment uptake among incarcerated people in Norway, 2018-2019.","authors":"Eirik Opheim, Anette Fredriksen, Joakim Hauge, Olav Dalgard, Kristian Braathen Malme, Håvard Midgard","doi":"10.1080/00365521.2026.2685826","DOIUrl":"10.1080/00365521.2026.2685826","url":null,"abstract":"Introduction: Chronic hepatitis C virus (HCV) infection is common among imprisoned people. We aimed to assess HCV treatment uptake and associated factors before and after imprisonment among incarcerated individuals with chronic HCV infection.Methods: Newly incarcerated individuals in six Norwegian prisons were consecutively included in 2018-2019 and tested for HCV infection. The cohort was linked to national registries for HCV notification status and treatment dispensations. Treatment initiation was defined as dispensation of ≥1 pack (28 days) of HCV treatment.Results: Among 110 individuals with previous or current chronic HCV infection, the median age was 37 years, 79.1% male and 97.2% had ever injected drugs. Chronic HCV infection had been diagnosed in 88 persons before incarceration, of whom 34 (38.6%; 95% CI 28.4-49.6) had already initiated treatment. Among 76 with detectable HCV RNA at inclusion, 62 (81.6%; 95% CI 71.0-89.5) received treatment after incarceration, with a median time to treatment of 5.1 months. Treatment rates increased from 10.6/100 PY (95% CI 7.4-14.9) in the period before incarceration to 79.4/100 PY (95% CI 60.9-101.8) after incarceration. Following incarceration, time to treatment was shorter among individuals with sentence length ≥3 months than among those on remand or with shorter sentences (aHR 1.93; 95% CI 1.10-3.41; p < 0.001). Treatment completion was observed in 57 of 62 (91.9%) participants who initiated treatment after incarceration.Conclusion: HCV treatment uptake following incarceration was high, particularly among those with long sentences. HCV testing in prison should be followed by immediate treatment initiation, regardless of incarceration status and sentence length.","PeriodicalId":21461,"journal":{"name":"Scandinavian Journal of Gastroenterology","volume":" ","pages":"947-955"},"PeriodicalIF":1.8,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148239917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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