Scandinavian Journal of Gastroenterology最新文献

{"title":"Transcutaneous vagus nerve stimulation does not affect gastrointestinal function in subjects with diabetic autonomic neuropathy.","authors":"Daniel Gerdt Kahlke, Esben Bolvig Mark, Davide Bertoli, Abdullah Samer A Al-Abdali, Ditte Smed Kornum, Huda Kufaishi, Klaus Krogh, Filip Knop, Christian Stevns Hansen, Birgitte Brock, Christina Brock, Asbjørn Mohr Drewes, Jens Brøndum Frøkjær","doi":"10.1080/00365521.2025.2572620","DOIUrl":"https://doi.org/10.1080/00365521.2025.2572620","url":null,"abstract":"<p><strong>Background and aims: </strong>Transcutaneous vagus nerve stimulation has been suggested to alleviate gastrointestinal symptoms in subjects with diabetic autonomic neuropathy. This study aimed to examine the effect of this treatment on magnetic resonance imaging (MRI)-assessed gastrointestinal function.</p><p><strong>Methods: </strong>This study included data from a randomized, sham-controlled, double-blind parallel group trial. Subjects with type 1 or 2 diabetes with manifest gastrointestinal symptoms and diabetic autonomic neuropathy were included. Subjects were randomized to one week of active or sham transcutaneous vagus nerve stimulation. A meal-stimulated pan-alimentary MRI scan protocol was performed after the one week stimulation. Gastric, small bowel, and colonic volumes were assessed, as were gastric half-emptying time, small bowel motility, and gastrointestinal symptom scores.</p><p><strong>Key results: </strong>Thirty-four patients were included. Eighteen and sixteen patients were randomized to active and sham treatment, respectively. Gastric, small bowel, and colonic volumes were not different between treatment groups at any post-meal time points after one week of treatment (all <i>p</i> > 0.80). Gastric half-emptying time was not different between active and sham groups (105+/-37 min vs. 101+/-36 min, <i>p</i> = 0.77). Small bowel motility 105 min postprandially was higher in the active group compared to sham (184 ± 53 au. vs. 138+/-28 au., <i>p</i> = 0.04), whereas none of the remaining time points showed any differences (all <i>p</i> > 0.47). Symptom scores were unaffected by treatment (all <i>p</i> > 0.51), and no correlations between symptom scores and MRI measurements were found (all <i>p</i> > 0.16).</p><p><strong>Conclusions: </strong>Transcutaneous vagus nerve stimulation did not affect MRI-assessed gastrointestinal function in subjects with diabetic autonomic neuropathy.</p>","PeriodicalId":21461,"journal":{"name":"Scandinavian Journal of Gastroenterology","volume":" ","pages":"1-11"},"PeriodicalIF":1.7,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145275636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction.","authors":"","doi":"10.1080/00365521.2025.2569976","DOIUrl":"https://doi.org/10.1080/00365521.2025.2569976","url":null,"abstract":"","PeriodicalId":21461,"journal":{"name":"Scandinavian Journal of Gastroenterology","volume":" ","pages":"1"},"PeriodicalIF":1.7,"publicationDate":"2025-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145239408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of gallstone intervention during pregnancy on maternal and perinatal outcomes: a nationwide population-based cohort study.","authors":"Bodil Andersson, Jonas Hedström, Dag Wide-Swensson, Johan Nilsson","doi":"10.1080/00365521.2025.2526773","DOIUrl":"10.1080/00365521.2025.2526773","url":null,"abstract":"<p><strong>Background and aims: </strong>Gallstone disease during pregnancy can have varying consequences, from mild to severe and even life-threatening. The aim was to investigate how gallstone intervention during pregnancy impacts pregnancy, delivery and the newborn child.</p><p><strong>Methods: </strong>Pregnant patients 18-45 years identified from the Swedish National Register for Gallstone Surgery and Endoscopic Retrograde Cholangiopancreatography (GallRiks) 2009-2016 constituted the intervention group and were cross-linked with the Swedish National Medical Birth Register. A 1:5 matched control group of patients without gallstone intervention during pregnancy was established.</p><p><strong>Results: </strong>In total, 1620 women were included, and of these, 274 underwent gallstone intervention during pregnancy. Some 221 women underwent cholecystectomy only, and 53 underwent ERCP only or combined with cholecystectomy. The women in the intervention group had a higher BMI at the start of pregnancy (24 vs 28, <i>p</i> < .001) and were more often smokers (21.7% vs. 15.7%, <i>p</i> = .019). Overall, labour started most often spontaneously, (intervention group 67.0% vs. control group 75.3%, <i>p</i> = .004), and elective caesarean section was more common in the intervention group (13.2 vs. 9.0%, <i>p</i> = .034). Premature birth was more common in the intervention group (19 [6.93%] vs. 5 [3.94%], <i>p</i> = .029), with an adjusted odds ratio of 1.8 (CI 1.1-3.3, <i>p</i> < .001). There were no differences in the children's birth weights or APGAR scores.</p><p><strong>Conclusions: </strong>Caesarean section was more common, and the duration of pregnancy was shorter, including preterm births, in the group with gallstone intervention during pregnancy. However, for the newborn child, birth weight corrected for gestational age and APGAR score was not affected.</p>","PeriodicalId":21461,"journal":{"name":"Scandinavian Journal of Gastroenterology","volume":" ","pages":"992-998"},"PeriodicalIF":1.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144592133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tight monitoring with colonoscopy and magnetic resonance enterography improves outcomes in patients with Crohn's disease.","authors":"Soyun Lim, Kwang Woo Kim, Jin Soo Moon, Se Hyung Kim, Seungbum Ryoo, Kyu Joo Park, Hyun Jung Lee, Jong Pil Im, Byeong Gwan Kim, Joo Sung Kim, Seong-Joon Koh","doi":"10.1080/00365521.2025.2544307","DOIUrl":"10.1080/00365521.2025.2544307","url":null,"abstract":"<p><strong>Background and aims: </strong>This study evaluated the impact of monitoring with colonoscopy and magnetic resonance enterography on clinical decision-making and long-term outcomes in advanced therapy-naïve Crohn's disease patients with moderate-to-severe disease.</p><p><strong>Methods: </strong>A retrospective review was conducted on 157 biologic-naïve Crohn's disease patients with moderate-to-severe disease at the initiation of advanced therapy between 2006 and 2023. Participants were categorized into three groups according to monitoring method within two years post-treatment: (1) tight monitoring (colonoscopy and magnetic resonance enterography), (2) semi-tight monitoring (either colonoscopy or magnetic resonance enterography), and (3) conventional monitoring (clinical outcomes including laboratory tests only). Treatment adjustments and long-term outcomes were compared.</p><p><strong>Results: </strong>Of 157 patients (69.4% male, median age 31 years), tight monitoring was associated with increased immunomodulator use (27.2% vs. 3.8%; <i>p</i> < 0.001) and reduced hospitalizations compared to conventional monitoring (5.4% vs. 38.8%; <i>p</i> < 0.001). The incidence of strictures was 0% in the tight monitoring group, compared to 21.3% in the conventional monitoring group, respectively (<i>p</i> = 0.011).</p><p><strong>Conclusion: </strong>Tight monitoring with both colonoscopy and magnetic resonance enterography within 2 years after advanced therapy initiation in patients with moderate-to-severe Crohn's disease is associated with timely treatment adjustments and improved long-term outcomes, particularly through better detection of residual inflammation.</p>","PeriodicalId":21461,"journal":{"name":"Scandinavian Journal of Gastroenterology","volume":" ","pages":"999-1010"},"PeriodicalIF":1.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144967048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic difference of esophageal squamous cell carcinoma based on tumor differentiation: a single center retrospective study.","authors":"Masato Hayashi, Makoto Abe, Takeshi Fujita, Hisayuki Matsushita","doi":"10.1080/00365521.2025.2548604","DOIUrl":"10.1080/00365521.2025.2548604","url":null,"abstract":"<p><strong>Background: </strong>Tumor differentiation is recognized as a prognostic predictor in certain malignancies such as gastric cancer. Although some studies have indicated a prognostic role for tumor differentiation in esophageal squamous cell carcinoma (ESCC), that is not widely known. Therefore, in this study, we retrospectively investigated the prognostic value of tumor differentiation in ESCC.</p><p><strong>Methods: </strong>This study investigated the prognostic value of tumor differentiation by using data from patients who underwent radical esophagectomy for ESCC. The characteristics of patients with well differentiated, moderately differentiated, and poorly differentiated ESCCs were investigated and compared Survival analysis was conducted using Kaplan-Meier analysis and the Cox proportional hazards model.</p><p><strong>Results: </strong>This study included 226 ESCC patients. The frequencies of each ESCC type were as follows: well-differentiated ESCC, 49 cases (21.7%); moderately differentiated ESCC, 149 cases (65.9%); and poorly differentiated ESCC, 28 cases (12.4%). Although Kaplan-Meier analysis showed no statistical significance for overall survival (OS) or recurrence (<i>p</i> = 0.083 and <i>p</i> = 0.36, respectively), Cox regression analysis demonstrated that tumor differentiation, particularly poorly differentiated ESCC, was a statistically significant factor for survival both in univariable and multivariable analyses (<i>p</i> = 0.03 and <i>p</i> < 0.01, respectively).</p><p><strong>Conclusions: </strong>Our findings suggest that tumor differentiation in ESCC may be a useful predictor of survival. However, owing to the small sample size, especially in patients who received preoperative treatment, further studies are required to establish definitive evidence.</p>","PeriodicalId":21461,"journal":{"name":"Scandinavian Journal of Gastroenterology","volume":" ","pages":"983-991"},"PeriodicalIF":1.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144967053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction.","authors":"","doi":"10.1080/00365521.2025.2557133","DOIUrl":"10.1080/00365521.2025.2557133","url":null,"abstract":"","PeriodicalId":21461,"journal":{"name":"Scandinavian Journal of Gastroenterology","volume":" ","pages":"I"},"PeriodicalIF":1.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145016115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Malpractice and compensation claims for acute pancreatitis in Norway: characteristics of claimants, claim-rates, outcomes and indemnity compensation.","authors":"Kjetil Søreide, Jannicke Horjen Møller, Kristian Strand, Annbjørg Hegelstad Søreide, Solveig Hodne, Lars N Karlsen","doi":"10.1080/00365521.2025.2537280","DOIUrl":"10.1080/00365521.2025.2537280","url":null,"abstract":"<p><strong>Background: </strong>Acute pancreatitis is a potential life-threatening disease derived from different aetiologies. Knowledge about malpractice claims in acute pancreatitis is lacking. The aim of this study was to investigate the occurrence, patterns and outcomes of malpractice claims for management of acute pancreatitis.</p><p><strong>Methods: </strong>Nationwide observational cohort of compensation claims filed in a single-payer, universal health care system with a national patient injury compensation system and reviewed by hospital specialists, primary care and health law.</p><p><strong>Results: </strong>Some 40 claims were filed, among 24,715 episodes of acute pancreatitis. On average, 4.4 claims/year were filed, or 1 claim per every 727 episode of acute pancreatitis. Six claims were directed at primary healthcare (general practitioners (<i>n</i> = 4) and the emergency outpatient units (<i>n</i> = 2)), with none approved. Of all claims, 9 (22.5%) were approved, most frequent for biliary aetiology and related to errors or deviation in treatment (8/9). In 3 of the approved claims, death was the outcome of and part of the compensation approval (one under 'rule of exemption' for unexpectedly severe outcome). The adult population-adjusted claims-rate increased from 1.92 to 2.48/million inhabitants during the period. The claim-rate for events of acute pancreatitis increased from 1.48 to 1.58/1000 events of acute pancreatitis. A total indemnity compensation of 3.6 mill NOK (317 000 EUR) was paid.</p><p><strong>Conclusion: </strong>Malpractice claims in acute pancreatitis are rare considering the number of episodes and variation in aetiology. Over 1 in 5 claims is granted compensation, most often related to treatment of biliary aetiology and for timing or indication of procedures.</p>","PeriodicalId":21461,"journal":{"name":"Scandinavian Journal of Gastroenterology","volume":" ","pages":"1032-1042"},"PeriodicalIF":1.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144708602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Combined biliary obstruction and gastric outlet obstruction management: comparison of various strategies of biliary stenting and duodenal derivation in terms of reintervention risk: an expert single-center experience.","authors":"Jean-Michel Gonzalez, Ivann Bouteiller, Diane Lorenzo, Mohamed Gasmi, Marc Barthet","doi":"10.1080/00365521.2025.2537895","DOIUrl":"10.1080/00365521.2025.2537895","url":null,"abstract":"<p><strong>Background: </strong>Double malignant biliary and duodenal obstruction is a frequent and debilitating complication of advanced biliopancreatic cancers. Endoscopic ultrasound (EUS)-guided biliary and enteric drainage techniques have emerged as alternatives to ERCP and duodenal stenting (DS), but optimal therapeutic sequencing remains unclear.</p><p><strong>Patients and methods: </strong>We conducted a retrospective monocentric study including 34 patients treated for DMBO-DDO between February 2015 and December 2023. Inclusion required histologically confirmed tumors with both distal malignant biliary obstruction (DMBO) and high-grade gastric outlet obstruction (GOO). Treatment sequences were guided by the first symptom and validated by a multidisciplinary team. The primary endpoint was biliary reintervention rate according to different therapeutic combinations. Secondary endpoints included technical and clinical success, adverse events, and global reintervention rates.</p><p><strong>Results: </strong>Mean patient age was 75 years, with pancreatic adenocarcinoma being the most common (58.8%). ERCP was the first procedure in 67.6% of cases. Technical success was 100% for all biliary interventions. The overall biliary reintervention rate was 52.9%, significantly higher in ERCP-based strategies (up to 77.8%) compared to EUS-guided approaches (18.2%-40%; <i>p</i> = 0.03). Lower initial bilirubin levels (<150 μmol/L) were also associated with increased reintervention rates (77.2% vs. 23.5%; <i>p</i> = 0.019). Complication rates were low (4.4% for grade ≥ III).</p><p><strong>Conclusions: </strong>ERCP-first strategies for DMBO in the association of GOO showed significantly higher biliary reintervention rates compared to EUS-guided approaches. These findings suggest that EUS-based drainage should be favored in selected patients. Prospective multicenter studies are needed to refine treatment algorithms and confirm predictive factors for reintervention.</p>","PeriodicalId":21461,"journal":{"name":"Scandinavian Journal of Gastroenterology","volume":" ","pages":"958-965"},"PeriodicalIF":1.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144967104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic factors for metastatic gastrointestinal stromal tumors treated with cytoreductive surgery: a retrospective cohort study.","authors":"Hai-Dong Zhang, Xiao-Nan Yin, Ming-Chun Mu, Hai-Ning Chen, Zhao-Lun Cai, Chao-Yong Shen, Yuan Yin, Bo Zhang","doi":"10.1080/00365521.2025.2544312","DOIUrl":"10.1080/00365521.2025.2544312","url":null,"abstract":"<p><strong>Background: </strong>Cytoreductive surgery (CRS) may benefit patients with metastatic gastrointestinal stromal tumors (GISTs) treated with tyrosine kinase inhibitors (TKIs). However, there is insufficient evidence on prognostic factors for metastatic GISTs undergoing CRS.</p><p><strong>Methods: </strong>This study reviewed metastatic GISTs that underwent CRS after receiving TKIs in our center from April 2014 to December 2023. We collected clinicopathologic characteristics and survival data for analyses <i>via</i> the Cox hazard model and Kaplan-Meier method.</p><p><strong>Results: </strong>Finally, 73 patients with metastatic GISTs who underwent CRS were enrolled. The TKI treatments used at time of surgery were imatinib (<i>n</i> = 53, 72.6%) and subsequent-line TKIs (<i>n</i> = 20, 27.4%). There were 30 patients (41.1%) with responsive disease (RD), 17 patients (23.3%) with unifocal progression disease (UP) and 26 patients (35.6%) with multifocal progression disease (MP) to TKIs at the time of surgery. The median follow-up time was 31 months. Multivariate Cox analysis revealed that MP (HR 2.406, <i>p</i> = 0.025), R2 resection (HR 2.532, <i>p</i> = 0.023), and mitotic index ≥5/50 HPFs (high-power fields) (HR 2.687, <i>p</i> = 0.022) independently predicted worse progression-free survival (PFS), and R2 resection predicted worse overall survival (OS) (HR 5.202, <i>p</i> = 0.039) for the entire cohort. In the subgroup analysis, radiographic response, extent of resection and mitotic index were prognostic factors for patients receiving imatinib but not those receiving subsequent-line TKIs. The rate of postoperative complications was 9.6% and the rate of grade III or higher complications was 4.1%.</p><p><strong>Conclusions: </strong>Non-MP, R0/1 resection and mitotic index < 5/50 HPFs may predict better outcomes for patients with metastatic GISTs on imatinib, and CRS is feasible and safe.</p>","PeriodicalId":21461,"journal":{"name":"Scandinavian Journal of Gastroenterology","volume":" ","pages":"972-982"},"PeriodicalIF":1.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144822459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Low rate of general anaesthesia and hospital admission following colonic saline-immersion/irrigation technique (SITE) endoscopic submucosal dissection (ESD).","authors":"Alessandro Rimondi, Georgios Kalopitas, Elisabet Maristany Bosch, Elisabetta Dell'Unto, Hironori Yamamoto, Edward John Despott, Alberto Murino","doi":"10.1080/00365521.2025.2531436","DOIUrl":"10.1080/00365521.2025.2531436","url":null,"abstract":"<p><strong>Introduction: </strong>Endoscopic submucosal dissection (ESD) for colonic lesions frequently requires general anaesthesia (GA) or deep sedation to be performed. Saline-immersion/irrigation technique (SITE) improves tolerability as it reduces bowel distension and less stretching of the mesentery. We describe our experience with operator-delivered sedation (OdS) SITE-ESD on a cohort of colonic ESD.</p><p><strong>Materials and methods: </strong>Retrospective single-centre study of consecutive anonymised patients who underwent SITE-ESD for colonic lesions from Nov-2017 to Feb-2025. Characteristics of patients and lesions, procedure outcomes and adverse events, details of sedation, and hospital admission were recorded.</p><p><strong>Results: </strong>One-hundred-thirty-eight colonic lesions were included. Median age: 68 (IQR 62-76), ASA II was the most prevalent score (61.1%), the median maximum diameter of lesions was 40 mm (IQR 30-50), and the median resection time was 120 min (IQR 75-180). One-hundred-twenty-seven (127, 92.0%) procedures were performed under OdS with midazolam (median 6 mg; IQR 3.5-7.5) and fentanyl (137.5 mcg; IQR 100-200). No procedure was abandoned due to discomfort. Eighty-one (58.7%) procedures were day cases and of the remaining 57, 46 (80.7%) required less than 48 hrs admission. One case of moderate respiratory failure was recorded (AGREE II).</p><p><strong>Discussion: </strong>SITE with OdS can be considered for colonic ESD.</p>","PeriodicalId":21461,"journal":{"name":"Scandinavian Journal of Gastroenterology","volume":" ","pages":"932-937"},"PeriodicalIF":1.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144660088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}